Aliases & Classifications for Pulmonary Emphysema

MalaCards integrated aliases for Pulmonary Emphysema:

Name: Pulmonary Emphysema 38 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9675
ICD10 33 J43.8
ICD9CM 35 492.8

Summaries for Pulmonary Emphysema

MalaCards based summary : Pulmonary Emphysema is related to alpha-1-antitrypsin deficiency and bronchitis, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Pulmonary Emphysema is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Simvastatin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Pulmonary Emphysema

Diseases in the Pulmonary Emphysema family:

Emphysema, Hereditary Pulmonary

Diseases related to Pulmonary Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 alpha-1-antitrypsin deficiency 32.9 ELANE ELN SERPINA1
2 bronchitis 30.9 ELANE SERPINA1 SERPINB1
3 vasculitis 30.4 ELANE SERPINA1 SERPINB1
4 pulmonary fibrosis 29.9 MMP9 SFTPD TIMP1
5 conjunctivochalasis 29.8 MMP1 TIMP1 TIMP2
6 wegener granulomatosis 29.8 ELANE ELN SERPINA1 SERPINB1
7 pneumothorax 29.7 ELN HMOX1 MMP9 SERPINA1
8 respiratory failure 29.7 ELANE SERPINA1 SFTPD
9 diffuse pulmonary fibrosis 29.7 SERPINA1 TIMP1
10 interstitial lung disease 29.7 MMP9 SFTPD TIMP1
11 bronchiectasis 29.6 ELANE MMP8 SERPINA1
12 cystic fibrosis 29.3 ELANE ELN SERPINA1 SFTPD
13 periodontitis 28.8 MMP1 MMP8 MMP9 TIMP1
14 lung disease 28.6 ELANE ELN MMP9 SERPINA1 SERPINB1 SFTPD
15 pulmonary fibrosis, idiopathic 28.6 ELANE MMP1 MMP9 SFTPD TIMP1
16 periodontal disease 27.8 ELANE MMP1 MMP8 MMP9 TIMP1 TIMP2
17 pulmonary disease, chronic obstructive 26.9 ELANE ELN HMOX1 MMP1 MMP9 SERPINA1
18 berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification 12.1
19 autosomal recessive cutis laxa type i 11.7
20 cerebral aneurysms 10.8 ELANE ELN
21 senile ectropion 10.7 ELN MMP9
22 elephantiasis 10.7 ELANE ELN
23 spastic entropion 10.7 MMP1 MMP9
24 erysipelas 10.7 ELANE ELN
25 gingival hypertrophy 10.7 MMP9 TIMP2
26 internal hemorrhoid 10.6 MMP1 MMP9
27 autoimmune inner ear disease 10.6 MMP9 TIMP1
28 chromoblastomycosis 10.6 MMP1 MMP9
29 impetigo herpetiformis 10.6 ELANE SERPINB1
30 chronic venous leg ulcers 10.6 MMP9 TIMP1
31 diabetic foot ulcers 10.6 MMP9 TIMP1
32 adult astrocytic tumour 10.5 MMP1 MMP9
33 chronic actinic dermatitis 10.5 ELN MMP1 MMP9
34 cryptogenic organizing pneumonia 10.5 MMP9 TIMP1
35 plasma protein metabolism disease 10.5 ELANE SERPINA1
36 conjunctival nevus 10.5 MMP9 TIMP1
37 pelvic organ prolapse 10.5 ELN MMP1 MMP9
38 aortic aneurysm, familial thoracic 1 10.5 ELN MMP1 MMP9
39 lipodermatosclerosis 10.4 MMP1 TIMP2
40 ischemic colitis 10.4 HMOX1 MMP9
41 central nervous system tuberculosis 10.4 ELANE MMP9 TIMP1
42 adenomyosis 10.4 MMP1 MMP9 TIMP2
43 amaurosis fugax 10.4 MMP8 MMP9
44 odontogenic myxoma 10.4 MMP1 MMP9
45 aortic disease 10.3 ELN MMP9 TIMP1
46 kawasaki disease 10.3 ELANE MMP9 TIMP1
47 periodontosis 10.3 ELANE MMP9
48 chronic venous insufficiency 10.3 MMP1 MMP9 TIMP1
49 venous insufficiency 10.3 MMP1 MMP9 TIMP1
50 microcystic meningioma 10.3 MMP9 TIMP1 TIMP2

Comorbidity relations with Pulmonary Emphysema via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Pulmonary Emphysema:



Diseases related to Pulmonary Emphysema

Symptoms & Phenotypes for Pulmonary Emphysema

UMLS symptoms related to Pulmonary Emphysema:


coughing, hemoptysis, snoring

MGI Mouse Phenotypes related to Pulmonary Emphysema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 SERPINB1 ELANE SESN2 HMOX1 SFTPD ITGB6
2 hematopoietic system MP:0005397 9.97 SERPINB1 ELANE HMOX1 SFTPD ITGB6 TIMP1
3 immune system MP:0005387 9.9 SERPINB1 ELANE HMOX1 SFTPD ITGB6 TIMP1
4 neoplasm MP:0002006 9.35 ELANE TIMP1 MMP1 MMP8 MMP9
5 respiratory system MP:0005388 9.23 SERPINB1 SESN2 HMOX1 SFTPD ITGB6 TIMP1

Drugs & Therapeutics for Pulmonary Emphysema

Drugs for Pulmonary Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 264)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Not Applicable 564-25-0 54671203
3
Budesonide Approved Phase 4,Phase 3 51333-22-3 63006 5281004
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
6
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
7
Losartan Approved Phase 4 114798-26-4 3961
8
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90566-53-3 62924
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
12
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56-45-1 5951
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
14
Lactitol Investigational Phase 4 585-86-4 3871
15 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Anticholesteremic Agents Phase 4
17 Antimetabolites Phase 4,Phase 1,Not Applicable
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
19 Hypolipidemic Agents Phase 4,Phase 1
20 Lipid Regulating Agents Phase 4,Phase 1
21 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable
23 Antimalarials Phase 4,Not Applicable
24 Antiparasitic Agents Phase 4,Not Applicable
25 Antiprotozoal Agents Phase 4,Not Applicable
26 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33
Beclomethasone Phase 4,Phase 3,Not Applicable 4419-39-0 20469
34 Bromides Phase 4,Phase 3,Phase 2
35 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Cholinergic Agents Phase 4,Phase 2,Not Applicable
37 Cholinergic Antagonists Phase 4,Phase 2
38 Formoterol Fumarate Phase 4,Phase 3,Phase 2
39 glucocorticoids Phase 4,Phase 3,Phase 1,Not Applicable
40 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Parasympatholytics Phase 4,Phase 2
45 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
47 Tiotropium Bromide Phase 4,Phase 2 136310-93-5
48 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Not Applicable
49
Salmeterol xinafoate Phase 4,Phase 3,Not Applicable 94749-08-3 56801
50 Alpha 1-Antitrypsin Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 526)
# Name Status NCT ID Phase Drugs
1 AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation Unknown status NCT01460108 Phase 4
2 EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema Unknown status NCT00730301 Phase 4
3 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype Unknown status NCT01431625 Phase 4
4 Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00680641 Phase 4 Simvastatin;Placebo
5 Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00857038 Phase 4 Doxycycline;Placebo
6 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4 Tiotropium + formoterol/beclometasone;tiotropium + placebo
7 Airway Clearance for Prevention of COPD Exacerbation Unknown status NCT00181207 Phase 4
8 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
9 Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography Unknown status NCT01361984 Phase 4 Nebulized arformoterol;Salmeterol
10 Small Airways Evaluation and Treatment Unknown status NCT02526758 Phase 4 beclomethasone;formoterol;budesonide
11 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
12 Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency Completed NCT00261833 Phase 4
13 Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. Completed NCT00670007 Phase 4
14 Efficacy of Losartan in Preventing Progression of COPD Completed NCT00720226 Phase 4 Losartan;Placebo
15 Efficacy Study of the Effect of Budesonide on Emphysema Completed NCT00232674 Phase 4 Pulmicort (budesonide) Turbuhaler
16 Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients Completed NCT01336283 Phase 4
17 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00424528 Phase 4 Arformoterol Tartrate Inhalation Solution;Tiotropium;Arformoterol and Tiotropium;Placebo
18 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients Completed NCT00680056 Phase 4 Formoterol plus Placebo (Tiotropium);Formoterol plus Tiotropium
19 Dynamic Hyperinflation and Tiotropium Completed NCT00569270 Phase 4 tiotropium;placebo;tiotropium
20 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis Completed NCT03073798 Phase 4 Roflumilast;Placebo
21 Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study Completed NCT01110200 Phase 4 ADVAIR DISKUS 250/50 mg BID;SEREVENT 50 mcg BID
22 Inhaled Steroid Reduces Systemic Inflammation in COPD Completed NCT00175565 Phase 4 inhaled fluticasone 500 mcg b.i.d.
23 Change of Inspiratory Peak Flow in COPD Completed NCT00561886 Phase 4 Formoterol
24 Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients Completed NCT02181023 Phase 4 Aclidinium Bromide;Glycopyrronium Bromide
25 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
26 An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease Completed NCT00974805 Phase 4 Seretide 500 Accuhaler
27 Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD Completed NCT00571428 Phase 4 Arformoterol Tartrate Inhalation Solution;Arformoterol Tartrate Inhalation Solution;Placebo
28 Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD Completed NCT01745848 Phase 4 Roflumilast
29 A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00857766 Phase 4 ADVAIR DISKUS™ 250/50mcg
30 Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD Completed NCT02209974 Phase 4 Fluticasone;Inhaled Placebo
31 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
32 Costs & Outcomes of Hospitalization/Treatment With Levalbuterol & Albuterol in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Subjects Completed NCT00667797 Phase 4 levalbuterol HCl;albuterol Sulfate
33 Study of the Effect of the ROX AC1 on Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease (COPD) Patients Completed NCT00832611 Phase 4
34 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
35 Altitude Related Illness In Patients With Respiratory Disease Completed NCT02450968 Phase 4 Dexamethasone;Placebo
36 Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD Completed NCT01693003 Phase 4 Indacaterol;Tiotropium
37 Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude Completed NCT02450994 Phase 4 Dexamethasone;Placebo
38 Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00202189 Phase 4 Budesonide
39 GLASSIA Infusion Rate Study Completed NCT01651351 Phase 4
40 Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor) Completed NCT00396006 Phase 4
41 Losartan Effects on Emphysema Progression Recruiting NCT02696564 Phase 4 Losartan;Placebo
42 Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema Recruiting NCT02682147 Phase 4 Sildenafil
43 Smoking Cessation and Functional CT Assessment Recruiting NCT03382106 Phase 4 Sildenafil 20 MG;Placebo Oral Tablet
44 Stage 1 Study of ARALAST NP and GLASSIA in A1PI Recruiting NCT02722304 Phase 4
45 RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD Recruiting NCT02989935 Phase 4
46 Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep Recruiting NCT02150590 Phase 4 Oxygen;sham oxygen (room air)
47 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4 Low Dose Corticosteroids;High Dose Corticosteroids
48 Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease Recruiting NCT03156231 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
49 Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude Recruiting NCT03173508 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
50 Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude Recruiting NCT03177850 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule

Search NIH Clinical Center for Pulmonary Emphysema

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Emphysema cell therapies at LifeMap Discovery.

Genetic Tests for Pulmonary Emphysema

Anatomical Context for Pulmonary Emphysema

MalaCards organs/tissues related to Pulmonary Emphysema:

41
Lung, Bone, Liver, Heart, Testes, Bone Marrow, Endothelial

Publications for Pulmonary Emphysema

Articles related to Pulmonary Emphysema:

(show top 50) (show all 591)
# Title Authors Year
1
Progression of Pulmonary Emphysema and Continued Increase in Ectodomain Shedding of Cell Adhesion Molecule 1 After Cessation of Cigarette Smoke Exposure in Mice. ( 29892598 )
2018
2
Pulmonary Emphysema Quantification on Ultra-Low-Dose Computed Tomography Using Model-Based Iterative Reconstruction With or Without Lung Setting. ( 29958197 )
2018
3
MMP-12 activates protease activated receptor (PAR)-1, upregulates placenta growth factor and leads to pulmonary emphysema. ( 29722565 )
2018
4
Perception and Awareness of chronic obstructive pulmonary disease, Chronic Bronchitis and Pulmonary Emphysema in the Spanish Urban Population. ( 29428681 )
2018
5
Heterogeneity in pulmonary emphysema: Analysis of CT attenuation using Gaussian mixture model. ( 29444178 )
2018
6
Quantitative and Qualitative Assessment of Pulmonary Emphysema with T2-Weighted PROPELLER MRI in a High-Risk Population Compared to Low-Dose CT. ( 29514383 )
2018
7
An Additional Treatment Option for One-Sided Pulmonary Emphysema - A Case Report. ( 29895080 )
2018
8
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA). ( 29357994 )
2018
9
Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. ( 29515461 )
2018
10
Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy. ( 28584268 )
2017
11
Pulmonary Emphysema Cross-Linking with Pulmonary Fibrosis and Vice Versa: a Non-usual Experimental Intervention with Elastase and Bleomycin. ( 28534139 )
2017
12
Bacteriological incidence in pneumonia patients with pulmonary emphysema: a bacterial floral analysis using the 16S ribosomal RNA gene in bronchoalveolar lavage fluid. ( 28790814 )
2017
13
Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema. ( 28179328 )
2017
14
A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV. ( 28122034 )
2017
15
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial. ( 28186686 )
2017
16
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. ( 28186975 )
2017
17
The copper dependent-lysyl oxidases contribute to the pathogenesis of pulmonary emphysema in chronic obstructive pulmonary disease patients. ( 28965583 )
2017
18
Improvement of metabolic disorders by an EP(2) receptor agonist via restoration of the subcutaneous adipose tissue in pulmonary emphysema. ( 28263859 )
2017
19
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. ( 28807355 )
2017
20
Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. ( 28894173 )
2017
21
Mild pulmonary emphysema a risk factor for interstitial lung disease when using cetuximab for squamous cell carcinoma of the head and neck. ( 28741444 )
2017
22
Prognostic Value of Radiation Pneumonitis After Stereotactic Body Radiotherapy: Effect of Pulmonary Emphysema Quantitated Using CTA Images. ( 28655592 )
2017
23
Images in COPD: Combined Pulmonary Emphysema and Fibrosis with Pulmonary Hypertension. ( 28848914 )
2017
24
Pulmonary emphysema is a predictor of pneumothorax after CT-guided transthoracic pulmonary biopsies of pulmonary nodules. ( 28574995 )
2017
25
Unsupervised Discovery of Spatially-Informed Lung Texture Patterns for Pulmonary Emphysema: The MESA COPD Study. ( 29354811 )
2017
26
Pulmonary Rehabilitation Improves Exercise Capacity And Molecular Skeletal Muscle Adaptation In Pulmonary Emphysema Patients: 2972 Board #37 June 3, 3: 30 PM - 5: 00 PM. ( 27361541 )
2016
27
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model. ( 27644555 )
2016
28
Acute pulmonary emphysema in death by hanging: a morphometric digital study. ( 27448112 )
2016
29
Lung volume reduction of pulmonary emphysema: the radiologist task. ( 26807689 )
2016
30
Comparison of Serum Adiponectin in Smoke-induced Pulmonary Emphysema Rats Fed Different Diets. ( 26830990 )
2016
31
Development of digital phantoms based on a finite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantification. ( 27838881 )
2016
32
Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study. ( 27692154 )
2016
33
Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. ( 27382160 )
2016
34
Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice. ( 27555760 )
2016
35
Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens. ( 27445472 )
2016
36
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
37
Severity of pulmonary emphysema and lung cancer: analysis using quantitative lobar emphysema scoring. ( 27902611 )
2016
38
Therapeutic Targeting of the IL-6 Trans-signalling/mTORC1 Axis in Pulmonary Emphysema. ( 27373892 )
2016
39
The Effect of Bone Marrow Mononuclear Cells on Lung Regeneration and Apoptosis in a Simple Model of Pulmonary Emphysema. ( 27426096 )
2016
40
Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model. ( 27489022 )
2016
41
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis. ( 26180387 )
2015
42
Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema? ( 25939639 )
2015
43
Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. ( 26150711 )
2015
44
Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. ( 25651034 )
2015
45
Paratracheal air cysts: prevalence and relevance to pulmonary emphysema and bronchiectasis using thoracic multidetector CT. ( 25430529 )
2015
46
Pulmonary emphysema induced by methylphenidate: experimental study. ( 26018883 )
2015
47
Different profiles of notch signaling in cigarette smoke-induced pulmonary emphysema and bleomycin-induced pulmonary fibrosis. ( 25813392 )
2015
48
Development and analysis of a finite element model to simulate pulmonary emphysema in CT imaging. ( 26737750 )
2015
49
Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice. ( 26160987 )
2015
50
Influence of Sinogram-Affirmed Iterative Reconstruction on Computed Tomography-Based Lung Volumetry and Quantification of Pulmonary Emphysema. ( 26466107 )
2015

Variations for Pulmonary Emphysema

Expression for Pulmonary Emphysema

LifeMap Discovery
Genes differentially expressed in tissues of Pulmonary Emphysema patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 S100A12 S100 calcium binding protein A12 Lung - 3.38 0.026
2 SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Lung + 3.23 0.020
3 HLA-DOA major histocompatibility complex, class II, DO alpha Lung + 3.20 0.002
Search GEO for disease gene expression data for Pulmonary Emphysema.

Pathways for Pulmonary Emphysema

Pathways related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 ELANE HMOX1 MMP1 MMP8 MMP9 SERPINA1
2
Show member pathways
13.47 ITGB6 MMP1 MMP12 MMP8 MMP9 TIMP1
3
Show member pathways
13.14 ELN ITGB6 MMP1 MMP12 MMP8 MMP9
4
Show member pathways
12.26 ELANE ELN ITGB6 MMP1 MMP12 MMP8
5 11.94 MMP1 MMP12 MMP9
6 11.79 HMOX1 MMP1 MMP9 TIMP1
7 11.62 HMOX1 MMP9 TIMP1 TIMP2
8 11.52 ELN HMOX1 MMP9 SERPINA1 TIMP1
9 11.44 MMP1 MMP12 MMP9 TIMP1 TIMP2
10 11.16 HMOX1 MMP1 MMP9
11
Show member pathways
11.16 ELANE MMP1 MMP12 MMP8 MMP9 TIMP1
12 11.14 ELANE ELN MMP1 MMP9 TIMP2
13 10.98 MMP9 TIMP1 TIMP2
14 10.92 MMP9 TIMP2
15 10.77 MMP1 TIMP1
16 10.71 MMP1 MMP9

GO Terms for Pulmonary Emphysema

Cellular components related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 ELANE HMOX1 MMP12 MMP8 MMP9 SERPINA1
2 extracellular region GO:0005576 9.7 ELANE ELN MMP1 MMP12 MMP8 MMP9
3 ficolin-1-rich granule lumen GO:1904813 9.54 MMP9 SERPINA1 TIMP2
4 specific granule lumen GO:0035580 9.5 ELANE MMP8 TIMP2
5 tertiary granule lumen GO:1904724 9.43 MMP8 MMP9 TIMP2
6 extracellular matrix GO:0031012 9.23 ELN MMP1 MMP12 MMP8 MMP9 SERPINB1

Biological processes related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 ELANE MMP1 MMP12 MMP8 MMP9
2 cytokine-mediated signaling pathway GO:0019221 9.76 HMOX1 MMP1 MMP9 TIMP1
3 cellular protein metabolic process GO:0044267 9.71 MMP1 SERPINA1 SFTPD TIMP1
4 neutrophil degranulation GO:0043312 9.63 ELANE MMP8 MMP9 SERPINA1 SERPINB1 TIMP2
5 negative regulation of endopeptidase activity GO:0010951 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
6 negative regulation of peptidase activity GO:0010466 9.56 SERPINA1 SERPINB1 TIMP1 TIMP2
7 positive regulation of macroautophagy GO:0016239 9.51 HMOX1 SESN2
8 endodermal cell differentiation GO:0035987 9.49 MMP8 MMP9
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
10 negative regulation of metallopeptidase activity GO:1905049 9.37 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.26 MMP1 MMP12 MMP8 MMP9
12 extracellular matrix disassembly GO:0022617 9.23 ELANE ELN MMP1 MMP12 MMP8 MMP9

Molecular functions related to Pulmonary Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.88 MMP1 MMP12 MMP8 MMP9 TIMP1 TIMP2
2 peptidase activity GO:0008233 9.83 ELANE MMP1 MMP12 MMP8 MMP9
3 metallopeptidase activity GO:0008237 9.67 MMP1 MMP12 MMP8 MMP9
4 peptidase inhibitor activity GO:0030414 9.62 SERPINA1 SERPINB1 TIMP1 TIMP2
5 metalloendopeptidase activity GO:0004222 9.56 MMP1 MMP12 MMP8 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.46 TIMP1 TIMP2
7 protease binding GO:0002020 9.46 ELANE SERPINA1 TIMP1 TIMP2
8 serine-type endopeptidase activity GO:0004252 9.35 ELANE MMP1 MMP12 MMP8 MMP9
9 endopeptidase activity GO:0004175 8.92 ELANE MMP1 MMP12 MMP9

Sources for Pulmonary Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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