MCID: PLM013
MIFTS: 29

Pulmonary Immaturity

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Immaturity

MalaCards integrated aliases for Pulmonary Immaturity:

Name: Pulmonary Immaturity 12 15
Primary Atelectasis, in Perinatal Period 12 74
Primary Atelectasis of Newborn 12

Classifications:



External Ids:

Disease Ontology 12 DOID:424
ICD9CM 36 770.4
SNOMED-CT 69 42908004
ICD10 34 P28.0
UMLS 74 C0270163

Summaries for Pulmonary Immaturity

MalaCards based summary : Pulmonary Immaturity, also known as primary atelectasis, in perinatal period, is related to diaphragmatic hernia, congenital and surfactant metabolism dysfunction, pulmonary, 1. An important gene associated with Pulmonary Immaturity is MAPK4 (Mitogen-Activated Protein Kinase 4), and among its related pathways/superpathways are Diseases of metabolism and Surfactant metabolism. The drugs Poractant alfa and Pulmonary Surfactants have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pulmonary Immaturity

Graphical network of the top 20 diseases related to Pulmonary Immaturity:



Diseases related to Pulmonary Immaturity

Symptoms & Phenotypes for Pulmonary Immaturity

GenomeRNAi Phenotypes related to Pulmonary Immaturity according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.53 IRX3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 SFTPB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.53 SFTPB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.53 MAPK4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.53 MAPK4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.53 SFTPB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.53 MAPK4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.53 IRX3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.53 SFTPB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.53 MAPK4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 IRX3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.53 IRX3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.53 IRX3 MAPK4 SFTPB
14 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 IRX3

MGI Mouse Phenotypes related to Pulmonary Immaturity:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.35 IRX1 IRX3 MAPK4 SFTPB SFTPC
2 respiratory system MP:0005388 8.92 IRX1 MAPK4 SFTPB SFTPC

Drugs & Therapeutics for Pulmonary Immaturity

Drugs for Pulmonary Immaturity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Poractant alfa Approved Phase 3 129069-19-8
2 Pulmonary Surfactants Phase 3
3 Respiratory System Agents Phase 3,Phase 1,Phase 2
4
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
5 Anti-Inflammatory Agents Phase 1, Phase 2
6 glucocorticoids Phase 1, Phase 2
7 Betamethasone benzoate Phase 1, Phase 2
8 Anti-Asthmatic Agents Phase 1, Phase 2
9 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
10 Betamethasone-17,21-dipropionate Phase 1, Phase 2
11 Betamethasone sodium phosphate Phase 1, Phase 2
12 Hormones Phase 1, Phase 2
13 Hormone Antagonists Phase 1, Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
15 Calamus Not Applicable
16 Fibrin fragment D Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants Completed NCT01709409 Phase 3 Curosurf-Group1;BLES-group 2
2 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
3 Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants Unknown status NCT00904774
4 Supplemental Oxygen Study Unknown status NCT02464917 Not Applicable
5 Trial of a Limited Versus Traditional Oxygen Strategy During Resuscitation in Premature Newborns Completed NCT01697904 Not Applicable
6 Patient Comfort During High Flow Nasal Cannula Versus Nasal Continuous Airway Pressure (CPAP) Completed NCT01526226 Not Applicable
7 Comparison of Different Oxygen Delivery Strategies During Resuscitation of Babies Completed NCT00356902 Not Applicable
8 Pilot Study of the Effects of Exercise on Aging Among Older Persons With HIV Completed NCT01860261 Not Applicable
9 Diaphragmatic Electrical Activity in Preterm Infants on Non-Invasive Ventilation Recruiting NCT03422549 Not Applicable
10 Diaphragm Electrical Activity of Preterm Infants on nCPAP Versus NIHFV Recruiting NCT02267018 Not Applicable
11 Diaphragm Electrical Activity of Preterm Infants on nCPAP With Binasal Prongs Versus RAM Cannula Recruiting NCT03121781 Not Applicable
12 Magnetic Non-Invasive Acupuncture For Infant Comfort A Pilot Study in Preterm Infants Requiring Eye-exam for Retinopathy of Prematurity Recruiting NCT03650621 Not Applicable

Search NIH Clinical Center for Pulmonary Immaturity

Genetic Tests for Pulmonary Immaturity

Anatomical Context for Pulmonary Immaturity

MalaCards organs/tissues related to Pulmonary Immaturity:

42
Eye

Publications for Pulmonary Immaturity

Articles related to Pulmonary Immaturity:

# Title Authors Year
1
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. ( 19805361 )
2009
2
Prenatal glucocorticoid therapy reverses pulmonary immaturity in congenital diaphragmatic hernia in fetal sheep. ( 8857848 )
1996
3
Antenatal glucocorticoid corrects pulmonary immaturity in experimentally induced congenital diaphragmatic hernia in rats. ( 7520565 )
1994
4
Infrequency of pulmonary immaturity in an indigent population with preterm premature rupture of the membranes. ( 3574826 )
1987

Variations for Pulmonary Immaturity

Expression for Pulmonary Immaturity

Search GEO for disease gene expression data for Pulmonary Immaturity.

Pathways for Pulmonary Immaturity

Pathways related to Pulmonary Immaturity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 SFTPB SFTPC
2
Show member pathways
10.59 SFTPB SFTPC
3
Show member pathways
10.02 SFTPB SFTPC

GO Terms for Pulmonary Immaturity

Cellular components related to Pulmonary Immaturity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-coated endocytic vesicle GO:0045334 9.16 SFTPB SFTPC
2 lamellar body GO:0042599 8.96 SFTPB SFTPC
3 multivesicular body lumen GO:0097486 8.62 SFTPB SFTPC

Biological processes related to Pulmonary Immaturity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 SFTPB SFTPC
2 respiratory gaseous exchange GO:0007585 9.16 SFTPB SFTPC
3 metanephros development GO:0001656 8.96 IRX1 IRX3
4 specification of loop of Henle identity GO:0072086 8.62 IRX1 IRX3

Sources for Pulmonary Immaturity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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