MCID: PLM198
MIFTS: 34

Pulmonary Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Pulmonary Interstitial Emphysema

MalaCards integrated aliases for Pulmonary Interstitial Emphysema:

Name: Pulmonary Interstitial Emphysema 12
Interstitial Emphysema 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD9CM 34 518.1
NCIt 50 C34571
SNOMED-CT 67 11211003
ICD10 32 J98.2
UMLS 70 C1370824

Summaries for Pulmonary Interstitial Emphysema

Disease Ontology : 12 A pulmonary emphysema that is characterized by the abnormal location of gas within the pulmonary interstitium and lymphatics usually due to positive pressure ventilation.

MalaCards based summary : Pulmonary Interstitial Emphysema, also known as interstitial emphysema, is related to pulmonary emphysema and respiratory distress syndrome in premature infants. An important gene associated with Pulmonary Interstitial Emphysema is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Metabolism of proteins and Diseases of metabolism. Affiliated tissues include lung, neutrophil and bone marrow, and related phenotype is respiratory system.

Wikipedia : 73 Pulmonary interstitial emphysema (PIE) is a collection of air outside of the normal air space of the... more...

Related Diseases for Pulmonary Interstitial Emphysema

Diseases related to Pulmonary Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 pulmonary emphysema 30.4 SFTPD SFTPC
2 respiratory distress syndrome in premature infants 30.4 SFTPC SFTPB SFTPA1 ABCA3
3 respiratory failure 30.1 SFTPD SFTPC SFTPB ABCA3
4 newborn respiratory distress syndrome 30.0 SFTPD SFTPC SFTPB SFTPA1 ABCA3
5 meconium aspiration syndrome 29.9 SFTPB ABCA3
6 adult respiratory distress syndrome 29.9 SFTPD SFTPC SFTPB ABCA3
7 pneumonia 29.9 SFTPD SFTPC SFTPB
8 lung disease 29.8 SFTPD SFTPC SFTPB SFTPA1 ABCA3
9 bacterial pneumonia 29.8 SFTPD SFTPB
10 diaphragmatic hernia, congenital 29.7 TBX4 SFTPC SFTPB
11 interstitial lung disease 29.6 SFTPD SFTPC SFTPB ABCA3
12 pulmonary fibrosis 29.5 SFTPD SFTPC SFTPA1 ABCA3
13 pulmonary fibrosis, idiopathic 29.2 SFTPD SFTPC SFTPB SFTPA1 ABCA3
14 pneumothorax 10.6
15 bronchopulmonary dysplasia 10.4
16 lymphangiectasis 10.3
17 patent ductus arteriosus 1 10.2
18 pulmonary hemosiderosis 10.2 SFTPB ABCA3
19 respiratory distress syndrome, infant 10.1 SFTPC ABCA3
20 chronic congestive splenomegaly 10.1 SFTPC ABCA3
21 pneumothorax, primary spontaneous 10.1
22 pre-eclampsia 10.1
23 bronchiolitis 10.1
24 status asthmaticus 10.1
25 47,xyy 10.1
26 tracheal agenesis 10.1 SFTPD SFTPB
27 diaphragm disease 10.1 SFTPC SFTPB
28 ventilation pneumonitis 10.1 SFTPD ABCA3
29 pulmonary alveolar microlithiasis 10.1 SFTPD ABCA3
30 cryptogenic organizing pneumonia 10.1 SFTPD SFTPC
31 surfactant metabolism dysfunction, pulmonary, 1 10.0 SFTPC SFTPB ABCA3
32 fibrosis of extraocular muscles, congenital, 1 10.0
33 laryngomalacia 10.0
34 cystic disease of lung 10.0
35 sudden infant death syndrome 10.0
36 asthma 10.0
37 langerhans cell histiocytosis 10.0
38 bacterial sepsis 10.0
39 cardiac arrest 10.0
40 asphyxia neonatorum 10.0
41 hellp syndrome 10.0
42 eclampsia 10.0
43 histiocytosis 10.0
44 choriocarcinoma 10.0
45 congestive heart failure 10.0
46 allergic asthma 10.0
47 pleuroparenchymal fibroelastosis 10.0
48 combined pulmonary fibrosis-emphysema syndrome 10.0
49 allergic bronchopulmonary aspergillosis 10.0 SFTPD SFTPA1
50 pulmonary hypertension, primary, 1 9.9 TBX4 ABCA3

Comorbidity relations with Pulmonary Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Pulmonary Interstitial Emphysema:



Diseases related to Pulmonary Interstitial Emphysema

Symptoms & Phenotypes for Pulmonary Interstitial Emphysema

MGI Mouse Phenotypes related to Pulmonary Interstitial Emphysema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 ABCA3 CSF2RB SFTPA1 SFTPB SFTPC SFTPD

Drugs & Therapeutics for Pulmonary Interstitial Emphysema

Search Clinical Trials , NIH Clinical Center for Pulmonary Interstitial Emphysema

Genetic Tests for Pulmonary Interstitial Emphysema

Anatomical Context for Pulmonary Interstitial Emphysema

MalaCards organs/tissues related to Pulmonary Interstitial Emphysema:

40
Lung, Neutrophil, Bone Marrow, Brain

Publications for Pulmonary Interstitial Emphysema

Articles related to Pulmonary Interstitial Emphysema:

(show top 50) (show all 546)
# Title Authors PMID Year
1
Emphysema as a possible complication of infant respiratory distress syndrome leading to lung transplantation. 61
33559118 2021
2
Reply to risk factors for pulmonary interstitial emphysema in the preterm infant: Still more challenges than answers. 61
32496636 2021
3
Management of severe right lung cystic pulmonary interstitial emphysema in an infant at 24 weeks gestation with bedside selective left main stem bronchial intubation: Case report and review of the literature. 61
32986686 2021
4
Preeclampsia was a risk factor for pulmonary interstitial emphysema in preterm infants born ≤32 weeks of gestational age. 61
32369221 2021
5
Unilateral neonatal pulmonary interstitial emphysema managed conservatively: A case report. 61
33080119 2021
6
Traumatic reticuloperitonitis combined with embolic pneumonia and hepatitis as unusual symptoms of foreign body syndrome in a Holstein bull. 61
32810898 2021
7
A case of neonatal diabetes insipidus following dexamethasone for bronchopulmonary dysplasia. 61
33337391 2020
8
[UNILATERAL MULTI-CYSTIC LUNG DISEASE IN A PRETERM INFANT]. 61
33103392 2020
9
Selective lung ventilation in the management of unilateral pulmonary interstitial emphysema. 61
31997483 2020
10
Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study. 61
32443296 2020
11
A de novo 2.2 Mb recurrent 17q23.1q23.2 deletion unmasks novel putative regulatory non-coding SNVs associated with lethal lung hypoplasia and pulmonary hypertension: a case report. 61
32143628 2020
12
Interstitial Emphysema as a Rare Radiographic Presentation of Bronchial Dehiscence after Lung Transplant. 61
33425421 2020
13
Pneumothorax as a late complication of COVID-19. 61
32876299 2020
14
CT features of pulmonary interstitial emphysema. 61
31053558 2019
15
Differential Lung Ventilation Using a Bronchial Blocker in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Case Report. 61
31162224 2019
16
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks. 61
31043328 2019
17
Neonate with persisting respiratory distress after resolution of pneumothorax. 61
31506322 2019
18
Delivery room interventions to prevent bronchopulmonary dysplasia in preterm infants: a protocol for a systematic review and network meta-analysis. 61
31427322 2019
19
Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature. 61
31370828 2019
20
Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation. 61
31110714 2019
21
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. 61
29754462 2019
22
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. 61
30234591 2018
23
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. 61
30269779 2018
24
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. 61
30517264 2018
25
Behavioral Characteristics and Medicolegal Identification of Infanticide. 61
30896108 2018
26
Pneumoperitoneum in a neonate weighing less than 500 g. What do we really know about it? 61
29769190 2018
27
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury. 61
29651817 2018
28
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. 61
29765788 2018
29
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. 61
29743753 2018
30
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. 61
29554886 2018
31
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. 61
28851119 2018
32
Pulmonary Barotrauma Including Huge Pulmonary Interstitial Emphysema in an Adult with Status Asthmaticus: Diagnostic and Therapeutic Challenges. 61
30756032 2018
33
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. 61
28515969 2017
34
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. 61
28567320 2017
35
Humidifier disinfectant-associated lung injury in adults: Prognostic factors in predicting short-term outcome. 61
27147415 2017
36
Neonatal Pneumopericardium in a Nonventilated Term Infant: A Case Report and Review of the Literature. 61
29430316 2017
37
Steroid-induced resolution of refractory pulmonary interstitial emphysema. 61
26952563 2016
38
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. 61
26868169 2016
39
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. 61
27960245 2016
40
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. 61
27809884 2016
41
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. 61
27593885 2016
42
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27581993 2016
43
[Blunt chest trauma with pneumomediastinum and pneumoperitoneum secondary to Macklin effect. Case report]. 61
26769517 2016
44
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. 61
27435178 2016
45
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27539719 2016
46
Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter. 61
26340670 2016
47
Nasal Mask Versus Nasal Prongs for Delivering Nasal Continuous Positive Airway Pressure in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial. 61
26713987 2015
48
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. 61
26071368 2015
49
Pneumomediastinum, pneumorrhachis and subcutaneous emphysema associated with viral infections: Report of three cases. 61
26508192 2015
50
IMAGING DIAGNOSIS-SPONTANEOUS PNEUMOMEDIASTINUM SECONDARY TO PRIMARY PULMONARY PATHOLOGY IN A DALMATIAN DOG. 61
25388364 2015

Variations for Pulmonary Interstitial Emphysema

Expression for Pulmonary Interstitial Emphysema

Search GEO for disease gene expression data for Pulmonary Interstitial Emphysema.

Pathways for Pulmonary Interstitial Emphysema

Pathways related to Pulmonary Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 SFTPD SFTPC SFTPB SFTPA1 CSF2RB ABCA3
2
Show member pathways
11.52 SFTPD SFTPC SFTPB SFTPA1 CSF2RB
3 11.17 SFTPC SFTPA1
4
Show member pathways
10.98 SFTPD SFTPA1
5
Show member pathways
10.75 SFTPD SFTPC SFTPB SFTPA1 CSF2RB
6
Show member pathways
10.73 SFTPD SFTPC SFTPB SFTPA1 CSF2RB ABCA3

GO Terms for Pulmonary Interstitial Emphysema

Cellular components related to Pulmonary Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 SFTPD SFTPC SFTPB SFTPA1 ABCA3
2 endoplasmic reticulum membrane GO:0005789 9.73 SFTPD SFTPC SFTPB SFTPA1
3 multivesicular body GO:0005771 9.43 SFTPD SFTPB SFTPA1
4 rough endoplasmic reticulum GO:0005791 9.4 SFTPD SFTPA1
5 lamellar body GO:0042599 9.33 SFTPC SFTPB SFTPA1
6 multivesicular body lumen GO:0097486 9.32 SFTPC SFTPB
7 alveolar lamellar body GO:0097208 9.13 SFTPC SFTPB ABCA3
8 clathrin-coated endocytic vesicle GO:0045334 8.92 SFTPD SFTPC SFTPB SFTPA1

Biological processes related to Pulmonary Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 SFTPD SFTPC SFTPB SFTPA1 CSF2RB ABCA3
2 toll-like receptor signaling pathway GO:0002224 9.32 SFTPD SFTPA1
3 cell fate specification GO:0001708 9.26 TBX6 TBX4
4 surfactant homeostasis GO:0043129 9.16 SFTPD ABCA3
5 respiratory gaseous exchange GO:0007585 9.02 SFTPD SFTPC SFTPB SFTPA1 CSF2RB

Molecular functions related to Pulmonary Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 8.62 SFTPA1 ABCA3

Sources for Pulmonary Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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