MCID: PLM038
MIFTS: 31

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 15
Large Cell Lung Neuroendocrine Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 49 C5672 C6875
UMLS 71 C1265996 C1334363

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to neuroendocrine carcinoma and large cell carcinoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and thyroid.

Wikipedia : 74 Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 30.3 SYP NCAM1 CHGA ASCL1
2 large cell carcinoma 30.2 SYP NCAM1 CHGA
3 neuroendocrine tumor 29.6 SYP NCAM1 CHGA ASCL1
4 tubular adenocarcinoma 29.5 SYP NCAM1 CHGA
5 small cell cancer of the lung 29.3 SYP NCAM1 CHGA ASCL1
6 large cell neuroendocrine carcinoma 29.2 SYP NCAM1 KIF5B CHGA ASCL1 ALK
7 small cell carcinoma 29.0 SYP NCAM1 CHGA ASCL1 ALK
8 pulmonary neuroendocrine tumor 29.0 SYP NCAM1 CHGA ASCL1
9 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
10 pancreas lymphoma 10.3 SYP CHGA
11 small cell carcinoma of the bladder 10.3 SYP CHGA
12 acinar cell cystadenocarcinoma 10.3 SYP CHGA
13 vulvar eccrine porocarcinoma 10.3 SYP CHGA
14 gastrointestinal neuroendocrine benign tumor 10.3 SYP CHGA
15 appendix carcinoid tumor 10.3 SYP CHGA
16 auditory system cancer 10.3 SYP CHGA
17 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
18 thymus small cell carcinoma 10.3 SYP CHGA
19 breast papillary carcinoma 10.3 SYP CHGA
20 cauda equina neoplasm 10.3 SYP CHGA
21 adenocarcinoma 10.3
22 duodenal benign neoplasm 10.3 SYP CHGA
23 ampulla of vater neoplasm 10.3 SYP CHGA
24 vaginal tubulovillous adenoma 10.3 SYP CHGA
25 vaginal adenoma 10.3 SYP CHGA
26 middle ear adenoma 10.3 SYP CHGA
27 carotid body cancer 10.3 SYP CHGA
28 gastric neuroendocrine neoplasm 10.3 SYP CHGA
29 vaginal benign neoplasm 10.3 SYP CHGA
30 sensory organ benign neoplasm 10.3 SYP CHGA
31 cervical neuroblastoma 10.3 SYP CHGA
32 pineocytoma 10.3 SYP CHGA
33 lung oat cell carcinoma 10.3 SYP CHGA
34 cervix small cell carcinoma 10.3 SYP CHGA
35 pancreatic gastrinoma 10.3 SYP CHGA
36 gastrointestinal neuroendocrine tumor 10.3 SYP CHGA
37 carcinoid tumors, intestinal 10.3 SYP CHGA
38 ganglioneuroblastoma 10.3 SYP ALK
39 lung clear cell carcinoma 10.3 SYP CHGA
40 colon neuroendocrine neoplasm 10.3 SYP CHGA
41 carcinoid syndrome 10.3 SYP CHGA
42 binswanger's disease 10.3 SYP CHGA
43 pancreatic acinar cell adenocarcinoma 10.3 SYP CHGA
44 olfactory neuroblastoma 10.3 SYP CHGA
45 extra-adrenal pheochromocytoma 10.3 SYP CHGA
46 small intestine benign neoplasm 10.3 SYP CHGA
47 middle ear carcinoma 10.3 SYP CHGA
48 gangliocytoma 10.3 SYP CHGA
49 granulosa cell tumor of the ovary 10.3 SYP CHGA
50 clear cell meningioma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


fever, dyspnea, hemoptysis, coughing

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4 Etoposide phosphate Phase 2
5 Albumin-Bound Paclitaxel Phase 2
6 Antimitotic Agents Phase 2
7 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma: a Prospective, Randomized, Open-label, Phase 2 Study Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) (EPNEC-GFPC 03-2017) Unknown status NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

40
Lung, Prostate, Thyroid, Breast, Brain, Bronchial Epithelium, Thymus

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 82)
# Title Authors PMID Year
1
A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. 61
31593583 2020
2
Disparity in clinical outcomes between pure and combined pulmonary large-cell neuroendocrine carcinoma: A multi-center retrospective study. 61
31775086 2020
3
DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile. 61
31678831 2019
4
Surgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical localization. 61
31870515 2019
5
The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma. 61
31694833 2019
6
First report of pulmonary large cell neuroendocrine carcinoma treated with stereotactic body radiation therapy. 61
31516396 2019
7
Neuroendocrine marker staining pattern categorization of small-sized pulmonary large cell neuroendocrine carcinoma. 61
31583856 2019
8
Incidence of composite intestinal adenoma-microcarcinoid in 158 surgically resected polyps and its association with squamous morule. 61
31326865 2019
9
Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. 61
30734490 2019
10
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC). 61
30885341 2019
11
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? 61
30485478 2019
12
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. 61
30107896 2019
13
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. 61
30675274 2019
14
Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study. 61
30944773 2019
15
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. 61
30863102 2019
16
Double-edged role of radiotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. 61
31772675 2019
17
Prognostic significance of G6PD expression and localization in lung adenocarcinoma. 61
29753088 2019
18
Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma. 61
31560723 2019
19
Clinicopathological characteristics and prognosis of pulmonary large cell neuroendocrine carcinoma aged ≥65 years. 61
31149394 2019
20
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. 61
30591488 2019
21
Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report. 61
30572435 2018
22
[Pulmonary Non-tuberculous Mycobacteriosis Complicated with Pulmonary Large Cell Neuroendocrine Carcinoma;Report of a Case]. 61
30185750 2018
23
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. 61
29271588 2018
24
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? 61
29413048 2018
25
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. 61
29765234 2018
26
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. 61
29066508 2018
27
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. 61
28884744 2018
28
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. 61
28943940 2017
29
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. 61
28204910 2017
30
Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter? 61
28572122 2017
31
Molecular Profiling and Survival of Completely Resected Primary Pulmonary Neuroendocrine Carcinoma. 61
28024928 2017
32
Amrubicin monotherapy may be an effective second-line treatment for patients with large-cell neuroendocrine carcinoma or high-grade non-small-cell neuroendocrine carcinoma. 61
28529747 2017
33
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). 61
27903179 2016
34
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. 61
27368130 2016
35
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. 61
26960398 2016
36
Clinical features of large cell neuroendocrine carcinoma: a population-based overview. 61
26541538 2016
37
[Clinical Analysis of 22 Cases of Pulmonary Large Cell Neuroendocrine Cancer]. 61
26903161 2016
38
A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. 61
26622712 2015
39
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. 61
26039012 2015
40
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. 61
26176530 2015
41
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. 61
26060407 2015
42
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. 61
25364438 2014
43
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. 61
24966991 2014
44
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. 61
24023298 2013
45
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. 61
24649189 2013
46
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. 61
23312550 2013
47
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. 61
22498090 2013
48
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? 61
22579297 2012
49
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. 61
22400077 2012
50
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. 61
22359531 2012

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 SYP NCAM1 ASCL1

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hippocampus development GO:0021766 8.96 KIF5B ALK
2 neuron development GO:0048666 8.62 ASCL1 ALK

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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