Pulmonary Large Cell Neuroendocrine Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLM038 MIFTS: 35	Pulmonary Large Cell Neuroendocrine Carcinoma Categories: Cancer diseases, Neuronal diseases, Respiratory diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma ¹² ¹⁵

Large Cell Lung Neuroendocrine Carcinoma ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6658

NCIt ⁵¹ C5672 C6875

UMLS ⁷⁴ C1265996 C1334363

Sources

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and small cell carcinoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : ⁷⁷ Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

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Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)

#	Related Disease	Score	Top Affiliating Genes
1	large cell neuroendocrine carcinoma	31.5	CHGA SYP
2	small cell carcinoma	30.5	CHGA SYP
3	neuroendocrine tumor	30.2	CHGA SYP
4	large cell carcinoma	30.0	CHGA STK11 SYP
5	small cell cancer of the lung	29.6	CHGA SYP
6	lung cancer	29.0	ALK CHGA STK11 SYP
7	neuroendocrine carcinoma	10.8
8	adenocarcinoma	10.2
9	ureter small cell carcinoma	10.2	CHGA SYP
10	esophageal neuroendocrine tumor	10.2	CHGA SYP
11	urinary bladder small cell neuroendocrine carcinoma	10.2	CHGA SYP
12	ovarian large-cell neuroendocrine carcinoma	10.2	CHGA SYP
13	auditory system cancer	10.2	CHGA SYP
14	acinar cell cystadenocarcinoma	10.2	CHGA SYP
15	peritoneal serous adenocarcinoma	10.2	CHGA SYP
16	cellular ependymoma	10.2	CHGA SYP
17	primary hepatic neuroendocrine carcinoma	10.2	CHGA SYP
18	small cell carcinoma of the bladder	10.2	CHGA SYP
19	gastrointestinal neuroendocrine tumor	10.2	CHGA SYP
20	gallbladder small cell carcinoma	10.2	CHGA SYP
21	atypical follicular adenoma	10.2	CHGA SYP
22	chordoid meningioma	10.2	CHGA SYP
23	olfactory groove meningioma	10.2	CHGA SYP
24	cauda equina neoplasm	10.2	CHGA SYP
25	pancreatic serous cystadenoma	10.2	CHGA SYP
26	cystadenoma	10.2	CHGA SYP
27	conventional angiosarcoma	10.2	CHGA SYP
28	olfactory nerve neoplasm	10.2	CHGA SYP
29	autonomic nervous system benign neoplasm	10.2	CHGA SYP
30	pulmonary sclerosing hemangioma	10.2	CHGA SYP
31	sclerosing hemangioma	10.2	CHGA SYP
32	hemangioma	10.2	CHGA SYP
33	pineocytoma	10.2	CHGA SYP
34	gastric small cell carcinoma	10.2	CHGA SYP
35	pancreatoblastoma	10.2	CHGA SYP
36	subependymoma	10.2	CHGA SYP
37	carcinoid tumors, intestinal	10.2	CHGA SYP
38	respiratory system benign neoplasm	10.2	CHGA SYP
39	anterior cranial fossa meningioma	10.2	CHGA SYP
40	gastric squamous cell carcinoma	10.2	CHGA SYP
41	pulmonary blastoma	10.2	CHGA SYP
42	pleomorphic xanthoastrocytoma	10.2	CHGA SYP
43	tanycytic ependymoma	10.1	CHGA SYP
44	papillary ependymoma	10.1	CHGA SYP
45	non-functioning pancreatic endocrine tumor	10.1	CHGA SYP
46	central neurocytoma	10.1	CHGA SYP
47	binswanger's disease	10.1	CHGA SYP
48	carcinoid syndrome	10.1	CHGA SYP
49	cervix small cell carcinoma	10.1	CHGA SYP
50	cerebellar liponeurocytoma	10.1	CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:

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Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:

fever, dyspnea, hemoptysis, coughing

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.35	ALK CHGA KIF5B STK11 VGF
2	nervous system	MP:0003631	9.02	ALK CHGA STK11 SYP VGF

Sources

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Synonyms:

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

157069-30-2

33069-62-4

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

7 Epi taxol

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

7-epi-Paclitaxel

7-Epipaclitaxel

7-Epi-paclitaxel

7-epi-Taxol

7-Epitaxol

7-Epi-taxol

AB00513812

ABI 007

abi-007

ABI007

ABI-007

Abraxane

Abraxane (TN)

Abraxane I.V. Suspension

Abraxis BioScience brand of albumin-bound paclitaxel

AC1L1IOG

AC1L1VJI

AC1L9AVF

AC-675

ACon1_002231

albumin-bound paclitaxel

Ambotz33069-62-4

ANX-513

Anzatax

Asotax

BIDD:PXR0046

Bio-0076

Bio1_000362

Bio1_000851

Bio1_001340

Bio2_000416

Bio2_000896

BMS 181339-01

BMS-181339

BMS-181339-01

BPBio1_000320

BRD-A23723433-001-01-2

BRD-A28746609-001-04-0

BRD-K62008436-001-03-1

Bris taxol

Bristaxol

BSPBio_000290

BSPBio_001152

BSPBio_002614

C07394

C466458

C47H51NO14

Capxol

CCRIS 8143

CHEBI:103439

CHEBI:45863

CHEMBL100910

CHEMBL418410

CHEMBL48

CID36314

CID441276

CID4666

CID6713921

CID6915727

cMAP_000068

CPD-8718

D00491

DB01229

DHP-107

DHP-208

DivK1c_000441

DRG-0190

DTS-301

Ebetaxel

EmPAC

Epitaxol

EU-0101201

Genaxol

Genetaxyl

Genexol

Genexol-PM

HMS1362J13

HMS1568O12

HMS1792J13

HMS1922K08

HMS1990J13

HMS2090D07

HMS2093K15

HMS501G03

HSDB 6839

I06-0014

IDI1_000441

IDI1_002171

Intaxel

KBio1_000441

KBio2_000492

KBio2_002016

KBio2_002509

KBio2_003060

KBio2_004584

KBio2_005077

KBio2_005628

KBio2_007152

KBio2_007645

KBio3_000903

KBio3_000904

KBio3_001834

KBio3_002987

KBioGR_000492

KBioGR_001893

KBioGR_002509

KBioSS_000492

KBioSS_002016

KBioSS_002517

LipoPac

LMPR0104390001

Lopac0_001201

LS-31070

MBT 0206

MEGxp0_001940

Micellar Paclitaxel

Mitotax

MLS000863266

MLS001077297

MLS002154218

MLS002172439

MLS002695976

MolPort-001-742-627

MolPort-003-665-783

MolPort-003-932-365

MPI-5018

nab-paclitaxel

Nanotaxel

NCGC00024995-02

NCGC00024995-03

NCGC00024995-04

NCGC00024995-05

NCGC00024995-06

NCGC00024995-07

NCGC00164367-01

NCGC00164367-02

NCGC00164367-03

nchembio.188-comp1

nchembio.2007.34-comp9

nchembio.215-comp9

nchembio853-comp6

NCI60_000601

Neuro_000060

NINDS_000441

NK 105

Nova-12005

NP-010981

NSC 125973

NSC125973

NSC-125973

NSC358882

OAS-PAC-100

OncoGel

Onxal

Onxol

Onxol, Taxol, Nov-Onxol, Paclitaxel

P1632

Paclical

Pacligel

paclitaxel

Paclitaxel

Paclitaxel (JAN/USP)

Paclitaxel (JAN/USP/INN)

Paclitaxel (Taxol)

Paclitaxel [USAN:INN:BAN]

Paclitaxel, (4 alpha)-isomer

Paxceed

Paxene

Paxoral

Plaxicel

Praxel

Prestwick0_000155

Prestwick1_000155

Prestwick2_000155

Prestwick3_000155

Probes2_000350

QW 8184

S1150_Selleck

S-8184 Paclitaxel Injectable Emulsion

SDCCGMLS-0066823.P001

SDP-013

SMP1_000228

SMR000394086

SMR000857385

SPBio_000943

SPBio_002229

Spectrum_001536

SPECTRUM1503908

Spectrum2_000872

Spectrum3_001057

Spectrum4_001197

Spectrum5_001491

ST50306996

T 7402

T1912_SIGMA

T7191_SIGMA

T7402_SIGMA

TA1

TaxAlbin

Taxol

TAXOL

TAXOL (TN)

Taxol a

Taxol A

Taxol Konzentrat

TAXOL, 10-EPI,

Taxol, bris

Taxol.RTM. (Registered Trademark)

TXL

UNII-P88XT4IS4D

UPCMLD-DP108:001

UPCMLD-DP108:002

Vascular Wrap

weekly paclitaxel

Xorane

Yewtaxan

Etoposide

Approved

Phase 2

33419-42-0

36462

Synonyms:

(−)-etoposide

(-)-Etoposide

121471-01-0

136598-18-0

201594-04-9

33419-42-0

35317-32-9

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside

4-demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside

4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin

51854-34-3

76576-58-4

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

AB00438905

AC1L1FN8

AC1L1VT3

AC1L6246

AC1NR4OG

AC1O4WGG

AC1O7M1N

AC1Q47JJ

alpha-D-Glucopyranosyl isomer etoposide

Ambap33419-42-0

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bio1_000489

Bio1_000978

Bio1_001467

BPBio1_000673

BRD-K37798499-001-02-5

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

BSPBio_000611

C01576

CCRIS 2392

Celltop

CHEBI:4911

CHEBI:588795

CHEMBL44657

CID11758093

CID284997

CID3310

CID36462

CID5284558

CID6419930

CID6610299

CPD000112002

D00125

DB00773

DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,

Demethyl epipodophyllotoxin ethylidine glucoside

Demethyl Epipodophyllotoxin Ethylidine Glucoside

Demethyl-epiodophyllotoxin ethylidene glucoside

Demethylepipodophyllotoxin-beta-D-ethylideneglucoside

E0675

E1383_SIGMA

EINECS 251-509-1

Epipodophyllotoxin VP-16213

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

Eposide

Eposin

Eposin, Vepesid, VP-16, Toposar, Etoposide

eto GRY

eto-GRY

Etomedac

ETOP

Etopol

Etopophos

Etopophos (phosphate salt)

Etopos

etoposide

Etoposide

Etoposide (JP15/USP/INN)

Etoposide (VP16)

Etoposide [USAN:INN:BAN:JAN]

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido [INN-Spanish]

etoposido Ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Etosid

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

HMS1569O13

HMS2052N05

HMS2089F14

HSDB 6517

I06-0248

KBioSS_002410

Lastet

Lemery brand OF etoposide

LS-1214

Medac brand OF etoposide

MLS000049957

MLS001074951

MLS001424283

MLS002153463

MLS002207239

MLS002222184

MolPort-003-983-431

MolPort-004-905-001

MolPort-004-955-161

NCGC00025056-02

NChemBio.2007.10-comp19

nchembio.573-comp8

nchembio873-comp2

NK 171

Novartis brand OF etoposide

NSC 141540

NSC141540

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Prestwick_211

Prestwick0_000396

Prestwick1_000396

Prestwick2_000396

Prestwick3_000396

Riboposid

Ribosepharm brand OF etoposide

S1225_Selleck

SAM001246880

Sanfer brand OF etoposide

SMR000112002

SPBio_002532

ST056353

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Toposar

trans-Etoposide

UNII-6PLQ3CP4P3

Vepesid

VePesid

VePESID (TN)

Vepesid J

Vepeside

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16 (pharmaceutical)

VP 16213

VP 16-213

VP-16

VP-16-213

ZINC03830818

ZINC03938684

Zuyeyidal

Carboplatin

Approved

Phase 2

41575-94-4

38904 10339178 498142

Synonyms:

(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum

/h1-3H2,(H,7,8)(H,9,10)

1,1-Cyclobutanedicarboxylate diammine platinum (II)

1,1-Cyclobutanedicarboxylate diammine platinum(II)

2*-1

2*1H2

41575-94-4

70903-55-8

AC-1457

AC1L8I6U

Ambap41575-94-4

azanide

Blastocarb

BSPBio_003145

C 2538

C2043

C2538_SIGMA

C6H10N2O4Pt

Carbopaltin

Carboplat

carboplatin

Carboplatin

Carboplatin (JAN/USP/INN)

Carboplatin (USAN)

Carboplatin [USAN:INN:BAN:JAN]

Carboplatine

Carboplatine [French]

Carboplatino

Carboplatino [Spanish]

Carboplatinum

Carboplatinum [Latin]

Carbosin

Carbotec

Cbdca

CBDCA

CCRIS 3404

CHEBI:31355

CHEMBL1351

CHEMBL288376

CID10339178

CID2567

CID38904

CID426756

CID498142

CID5352133

CID6398587

CID6603770

cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum

cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)

cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(cyclobutanedicarboxylato)platinum II

Cyclobutane-1,1-dicarboxylate

cyclobutane-1,1-dicarboxylic acid

D01363

DB00958

Diammine(1,1-cyclobutanedicarboxylato)platinum (II)

Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum

diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum

Diammine-1,1-cyclobutane dicarboxylate platinum II

DivK1c_000892

EINECS 255-446-0

Ercar

EU-0100230

HMS1921J16

HMS2090M05

HMS2092B22

HMS502M14

HSDB 6957

I14-2390

IDI1_000892

InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6

IUPAC: Azane

JM 8

JM8

JM-8

KBio1_000892

KBio2_002009

KBio2_004577

KBio2_007145

KBio3_002645

KBioGR_000713

KBioSS_002009

Lopac0_000230

Lopac-C-2538

LS-117689

MolPort-003-665-501

MolPort-003-845-609

NCGC00015223-01

NCGC00093695-01

NCGC00094961-01

NCGC00094961-02

NCGC00094961-03

NCGC00162099-01

NCGC00162099-02

NCGC00167800-01

NCGC00178242-01

nchembio.573-comp10

nchembio773-comp2

nchembio873-comp3

Nealorin

Neocarbo

NINDS_000892

NSC 201345

NSC 241240

NSC201345

NSC241240

NSC-241240

Paraplatin

Paraplatin (TN)

Paraplatin, Carboplatin

Paraplatin-AQ

Platinum(+2) Cation

platinum(2+)

Platinum(II), (1, 1-cyclobutanedicar

Platinum, {diammine[1,1-cyclobut

Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Ribocarbo

S1215_Selleck

SPBio_000716

Spectrum_001529

SPECTRUM1502106

Spectrum2_000898

Spectrum3_001503

Spectrum4_000337

Spectrum5_001094

UNII-BG3F62OND5

Topoisomerase Inhibitors

Phase 2

Etoposide phosphate

Phase 2

Antimitotic Agents

Phase 2

Albumin-Bound Paclitaxel

Phase 2

Antineoplastic Agents, Phytogenic

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma	Unknown status	NCT02943798	Phase 2	etoposide plus carboplatin;Paclitaxel plus carboplatin
2	Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC)	Not yet recruiting	NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

⁴²

Lung, Brain, Prostate, Bronchial Epithelium

Sources

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 48)

#	Title	Authors	Year
1	Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )	Zhao Y...Bowes D	2019
2	Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. ( 30591488 )	Shimizu N...Wakasa T	2019
3	CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. ( 30675274 )	Piao Y...Gao Y	2019
4	Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. ( 30734490 )	Yang Q...Sun J	2019
5	Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. ( 30863102 )	Jo IY...Yeo SG	2019
6	Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )	Inage T....Yoshino I.	2018
7	Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )	Zhou F....Zhou C.	2018
8	Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )	Tang H....Wu Y.	2018
9	Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )	Derks J.L....Dingemans A.C.	2018
10	Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report. ( 30572435 )	Wei J...Lu YF	2018
11	Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )	Yang G....Liu S.	2017
12	Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )	Kim K.W....Choi Y.L.	2017
13	Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )	Rekhtman N....Joubert P.	2017
14	Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )	Rekhtman N....Ladanyi M.	2016
15	Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )	Makino T....Iyoda A.	2016
16	Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )	Kawabe T....Hashimoto N.	2016
17	PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )	Sabari J....Rekhtman N.	2016
18	Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )	Mestre T....Cardoso J.	2015
19	Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )	Fasano M....Morgillo F.	2015
20	Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )	Zhang X.K....Zhang L.	2015
21	Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )	Ogawa H....Maniwa Y.	2014
22	Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )	Ishida M....Okabe H.	2014
23	Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )	Tanaka Y....Yoshimura M.	2013
24	Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )	Iyoda A....Satoh Y.	2013
25	TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )	Odate S....Katano M.	2013
26	Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )	Odate S....Katano M.	2013
27	Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )	Shimizu K....Kato R.	2012
28	Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )	Terada T.	2012
29	Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )	Sun J.M....Park K.	2012
30	Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )	Iyoda A....Satoh Y.	2011
31	Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )	Rossi G....Cavazza A.	2011
32	A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )	Matsumoto T....Sato Y.	2009
33	Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )	Iyoda A....Yoshino I.	2009
34	A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )	Ohara G....Ohtsuka M.	2007
35	Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )	Iyoda A....Fujisawa T.	2007
36	Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )	Hiroshima K....Nakatani Y.	2006
37	Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )	Iyoda A....Fujisawa T.	2006
38	Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )	Kozuki T....Tanimoto M.	2005
39	Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )	Shin J.H....Kim S.K.	2005
40	Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )	Hiroshima K....Horai T.	2005
41	Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )	Hiroshima K....Ohwada H.	2004
42	Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )	Iyoda A....Fujisawa T.	2004
43	Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )	Iyoda A....Fujisawa T.	2004
44	Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )	Hage R....van den Bosch J.	2003
45	Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma. ( 26680943 )	Park MS...Chang J	2003
46	Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )	Iyoda A....Ohwada H.	2001
47	High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )	Yamanishi M....Yamanaka N.	2001
48	Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )	Demirer T....Aboulafia D.	1994

Sources

Genes for Pulmonary Large Cell Neuroendocrine Carcinoma

Genes related to Pulmonary Large Cell Neuroendocrine Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYP	Synaptophysin	Protein Coding	22.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	VGF	VGF Nerve Growth Factor Inducible	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CHGA	Chromogranin A	Protein Coding	21.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	21.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	KIF5B	Kinesin Family Member 5B	Protein Coding	17.02	GeneCards inferred via : Publications (show sections)
6	STK11	Serine/Threonine Kinase 11	Protein Coding	14.86	DISEASES inferred ¹⁵

Sources

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Sources

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

Sources

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic vesicle	GO:0031410	9.13	CHGA SYP VGF
2	transport vesicle	GO:0030133	8.62	CHGA VGF

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose homeostasis	GO:0042593	8.96	STK11 VGF
2	hippocampus development	GO:0021766	8.62	ALK KIF5B

Sources

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia