MCID: PLM038
MIFTS: 35

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 15
Large Cell Lung Neuroendocrine Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 50 C5672 C6875

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and small cell carcinoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways is Neuroscience. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone.

Wikipedia : 76 Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 31.0 CHGA ENO2 SYP
2 small cell carcinoma 30.0 CHGA ENO2 SYP
3 neuroendocrine tumor 29.8 CHGA ENO2 SYP
4 small cell cancer of the lung 29.8 CHGA ENO2 SYP
5 large cell carcinoma 29.6 CHGA ENO2 ROS1 SYP
6 ureter small cell carcinoma 10.1 CHGA SYP
7 esophageal neuroendocrine tumor 10.1 CHGA SYP
8 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA SYP
9 adenoma of the pancreas 10.1 CHGA SYP
10 acinar cell cystadenocarcinoma 10.1 CHGA SYP
11 peritoneal serous adenocarcinoma 10.1 CHGA SYP
12 cellular ependymoma 10.1 CHGA SYP
13 primary hepatic neuroendocrine carcinoma 10.1 CHGA SYP
14 gastrointestinal neuroendocrine tumor 10.1 CHGA SYP
15 chordoid meningioma 10.1 CHGA SYP
16 olfactory groove meningioma 10.1 CHGA SYP
17 pancreatic serous cystadenoma 10.1 CHGA SYP
18 cystadenoma 10.1 CHGA SYP
19 conventional angiosarcoma 10.1 CHGA SYP
20 pulmonary sclerosing hemangioma 10.1 CHGA SYP
21 sclerosing hemangioma 10.1 CHGA SYP
22 pancreatoblastoma 10.1 CHGA SYP
23 anterior cranial fossa meningioma 10.1 CHGA SYP
24 nervous system benign neoplasm 10.1 ENO2 SYP
25 pulmonary blastoma 10.1 CHGA SYP
26 ependymoma 10.1 ENO2 SYP
27 pleomorphic xanthoastrocytoma 10.1 CHGA SYP
28 tanycytic ependymoma 10.1 CHGA SYP
29 non-functioning pancreatic endocrine tumor 10.1 CHGA SYP
30 carotid body cancer 10.1 ENO2 SYP
31 malignant sertoli cell tumor 10.1 ENO2 SYP
32 lung cancer 10.1
33 adenocarcinoma 10.1
34 binswanger's disease 10.1 CHGA SYP
35 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
36 pancreatic somatostatinoma 10.1 ENO2 SYP
37 cutaneous ganglioneuroma 10.1 ENO2 SYP
38 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
39 papillary tumor of the pineal region 10.1 ENO2 SYP
40 sensory organ benign neoplasm 10.1 ENO2 SYP
41 orbital cancer 10.1 ENO2 SYP
42 middle ear adenoma 10.1 ENO2 SYP
43 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
44 cerebellum cancer 10.1 ENO2 SYP
45 clear cell ependymoma 10.1 ENO2 SYP
46 cerebral neuroblastoma 10.1 ENO2 SYP
47 endometrial small cell carcinoma 10.1 ENO2 SYP
48 extraosseous chondrosarcoma 10.1 ENO2 SYP
49 subependymal glioma 10.1 ENO2 SYP
50 malignant teratoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


fever, dyspnea, hemoptysis, coughing

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Etoposide Approved Phase 2 33419-42-0 36462
4 Topoisomerase Inhibitors Phase 2
5 Antineoplastic Agents, Phytogenic Phase 2
6 Etoposide phosphate Phase 2
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

41
Lung, Kidney, Bone, Spinal Cord, Thyroid, Pineal, Cerebellum

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 43)
# Title Authors Year
1
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
2
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
3
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
4
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
5
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2018
6
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )
2018
7
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
8
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
9
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
10
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )
2016
11
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )
2016
12
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )
2016
13
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )
2015
14
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )
2015
15
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )
2015
16
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )
2014
17
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )
2014
18
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )
2013
19
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )
2013
20
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )
2013
21
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )
2013
22
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )
2012
23
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )
2012
24
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )
2012
25
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )
2011
26
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )
2011
27
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )
2009
28
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )
2009
29
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )
2007
30
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )
2007
31
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )
2006
32
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )
2006
33
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )
2005
34
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )
2005
35
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )
2005
36
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )
2004
37
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )
2004
38
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )
2004
39
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )
2003
40
Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma. ( 26680943 )
2003
41
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )
2001
42
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )
2001
43
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

Pathways related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 NTRK2 SYP

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle GO:0030133 8.96 CHGA VGF
2 terminal bouton GO:0043195 8.62 NTRK2 SYP

Molecular functions related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 NTRK2 ROS1

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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