MCID: PLM038
MIFTS: 31

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 15
Large Cell Lung Neuroendocrine Carcinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 50 C5672 C6875
UMLS 72 C1265996 C1334363

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and neuroendocrine tumor, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 75 Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 31.8 SYP CHGA
2 neuroendocrine tumor 31.1 SYP CHGA
3 small cell carcinoma 31.0 SYP CHGA
4 large cell carcinoma 30.3 SYP STK11 CHGA
5 tubular adenocarcinoma 30.2 SYP CHGA
6 small cell cancer of the lung 29.7 SYP CHGA
7 lung cancer 28.4 SYP STK11 CHGA ALK
8 neuroendocrine carcinoma 10.8
9 ureter small cell carcinoma 10.3 SYP CHGA
10 adenocarcinoma 10.3
11 esophageal neuroendocrine tumor 10.3 SYP CHGA
12 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP CHGA
13 ovarian large-cell neuroendocrine carcinoma 10.3 SYP CHGA
14 auditory system cancer 10.3 SYP CHGA
15 acinar cell cystadenocarcinoma 10.3 SYP CHGA
16 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
17 cellular ependymoma 10.3 SYP CHGA
18 peritoneal serous adenocarcinoma 10.3 SYP CHGA
19 small cell carcinoma of the bladder 10.3 SYP CHGA
20 gastrointestinal neuroendocrine tumor 10.3 SYP CHGA
21 chordoid meningioma 10.3 SYP CHGA
22 atypical follicular adenoma 10.3 SYP CHGA
23 gallbladder small cell carcinoma 10.3 SYP CHGA
24 olfactory groove meningioma 10.3 SYP CHGA
25 cauda equina neoplasm 10.3 SYP CHGA
26 conventional angiosarcoma 10.3 SYP CHGA
27 pancreatic serous cystadenoma 10.3 SYP CHGA
28 cystadenoma 10.3 SYP CHGA
29 olfactory nerve neoplasm 10.3 SYP CHGA
30 autonomic nervous system benign neoplasm 10.3 SYP CHGA
31 pineocytoma 10.3 SYP CHGA
32 pulmonary sclerosing hemangioma 10.3 SYP CHGA
33 sclerosing hemangioma 10.3 SYP CHGA
34 hemangioma 10.3 SYP CHGA
35 subependymoma 10.3 SYP CHGA
36 pancreatoblastoma 10.3 SYP CHGA
37 gastric small cell carcinoma 10.3 SYP CHGA
38 anterior cranial fossa meningioma 10.3 SYP CHGA
39 respiratory system benign neoplasm 10.3 SYP CHGA
40 carcinoid tumors, intestinal 10.3 SYP CHGA
41 gastric squamous cell carcinoma 10.3 SYP CHGA
42 non-functioning pancreatic endocrine tumor 10.3 SYP CHGA
43 papillary ependymoma 10.2 SYP CHGA
44 tanycytic ependymoma 10.2 SYP CHGA
45 pleomorphic xanthoastrocytoma 10.2 SYP CHGA
46 pulmonary blastoma 10.2 SYP CHGA
47 carcinoid syndrome 10.2 SYP CHGA
48 binswanger's disease 10.2 SYP CHGA
49 central neurocytoma 10.2 SYP CHGA
50 cervix small cell carcinoma 10.2 SYP CHGA

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


fever, dyspnea, hemoptysis, coughing

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 ALK CHGA KIF5B STK11 VGF
2 nervous system MP:0003631 9.02 ALK CHGA STK11 SYP VGF

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4 Antineoplastic Agents, Phytogenic Phase 2
5 Tubulin Modulators Phase 2
6 Albumin-Bound Paclitaxel Phase 2
7 Topoisomerase Inhibitors Phase 2
8 Etoposide phosphate Phase 2
9 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma: a Prospective, Randomized, Open-label, Phase 2 Study Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) (EPNEC-GFPC 03-2017) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

41
Lung, Brain, Prostate, Bronchial Epithelium

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show top 50) (show all 74)
# Title Authors PMID Year
1
Incidence of composite intestinal adenoma-microcarcinoid in 158 surgically resected polyps and its association with squamous morule. 38
31326865 2019
2
Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. 38
30734490 2019
3
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC). 38
30885341 2019
4
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? 38
30485478 2019
5
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. 38
30675274 2019
6
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. 38
30107896 2019
7
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. 38
30863102 2019
8
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. 38
30591488 2019
9
Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study. 38
30944773 2019
10
Clinicopathological characteristics and prognosis of pulmonary large cell neuroendocrine carcinoma aged ≥65 years. 38
31149394 2019
11
Prognostic significance of G6PD expression and localization in lung adenocarcinoma. 38
29753088 2019
12
Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report. 38
30572435 2018
13
[Pulmonary Non-tuberculous Mycobacteriosis Complicated with Pulmonary Large Cell Neuroendocrine Carcinoma;Report of a Case]. 38
30185750 2018
14
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? 38
29413048 2018
15
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. 38
29271588 2018
16
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. 38
28884744 2018
17
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. 38
29066508 2018
18
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. 38
29765234 2018
19
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. 38
28943940 2017
20
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. 38
28204910 2017
21
Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter? 38
28572122 2017
22
Molecular Profiling and Survival of Completely Resected Primary Pulmonary Neuroendocrine Carcinoma. 38
28024928 2017
23
Amrubicin monotherapy may be an effective second-line treatment for patients with large-cell neuroendocrine carcinoma or high-grade non-small-cell neuroendocrine carcinoma. 38
28529747 2017
24
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). 38
27903179 2016
25
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. 38
27969491 2016
26
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. 38
27368130 2016
27
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. 38
26960398 2016
28
Clinical features of large cell neuroendocrine carcinoma: a population-based overview. 38
26541538 2016
29
[Clinical Analysis of 22 Cases of Pulmonary Large Cell Neuroendocrine Cancer]. 38
26903161 2016
30
A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. 38
26622712 2015
31
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. 38
26039012 2015
32
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. 38
26176530 2015
33
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. 38
26060407 2015
34
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. 38
25364438 2014
35
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. 38
24966991 2014
36
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. 38
24023298 2013
37
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. 38
24649189 2013
38
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. 38
22498090 2013
39
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. 38
23312550 2013
40
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? 38
22579297 2012
41
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. 38
22400077 2012
42
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. 38
22359531 2012
43
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. 38
22977617 2011
44
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. 38
21918393 2011
45
Large cell neuroendocrine carcinoma of the larynx: definition of an entity. 38
20589486 2010
46
Multidisciplinary approach in diagnosis of lung carcinoma. 38
20693974 2010
47
Comparison of chemotherapy for unresectable pulmonary high-grade non-small cell neuroendocrine carcinoma and small-cell lung cancer. 38
19699548 2010
48
Discriminant model for cytologic distinction of large cell neuroendocrine carcinoma from small cell carcinoma of the lung. 38
20125039 2010
49
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. 38
20398190 2010
50
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. 38
20082272 2009

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.13 VGF SYP CHGA
2 transport vesicle GO:0030133 8.62 VGF CHGA

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 8.96 VGF STK11
2 hippocampus development GO:0021766 8.62 KIF5B ALK

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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