MCID: PLM038
MIFTS: 35

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 15
Large Cell Lung Neuroendocrine Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 51 C5672 C6875

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and small cell carcinoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 77 Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from... more...

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 31.5 CHGA SYP
2 small cell carcinoma 30.5 CHGA SYP
3 neuroendocrine tumor 30.2 CHGA SYP
4 large cell carcinoma 30.0 CHGA STK11 SYP
5 small cell cancer of the lung 29.6 CHGA SYP
6 lung cancer 29.0 ALK CHGA STK11 SYP
7 neuroendocrine carcinoma 10.8
8 adenocarcinoma 10.2
9 ureter small cell carcinoma 10.2 CHGA SYP
10 esophageal neuroendocrine tumor 10.2 CHGA SYP
11 urinary bladder small cell neuroendocrine carcinoma 10.2 CHGA SYP
12 ovarian large-cell neuroendocrine carcinoma 10.2 CHGA SYP
13 auditory system cancer 10.2 CHGA SYP
14 acinar cell cystadenocarcinoma 10.2 CHGA SYP
15 peritoneal serous adenocarcinoma 10.2 CHGA SYP
16 cellular ependymoma 10.2 CHGA SYP
17 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
18 small cell carcinoma of the bladder 10.2 CHGA SYP
19 gastrointestinal neuroendocrine tumor 10.2 CHGA SYP
20 gallbladder small cell carcinoma 10.2 CHGA SYP
21 atypical follicular adenoma 10.2 CHGA SYP
22 chordoid meningioma 10.2 CHGA SYP
23 olfactory groove meningioma 10.2 CHGA SYP
24 cauda equina neoplasm 10.2 CHGA SYP
25 pancreatic serous cystadenoma 10.2 CHGA SYP
26 cystadenoma 10.2 CHGA SYP
27 conventional angiosarcoma 10.2 CHGA SYP
28 olfactory nerve neoplasm 10.2 CHGA SYP
29 autonomic nervous system benign neoplasm 10.2 CHGA SYP
30 pulmonary sclerosing hemangioma 10.2 CHGA SYP
31 sclerosing hemangioma 10.2 CHGA SYP
32 hemangioma 10.2 CHGA SYP
33 pineocytoma 10.2 CHGA SYP
34 gastric small cell carcinoma 10.2 CHGA SYP
35 pancreatoblastoma 10.2 CHGA SYP
36 subependymoma 10.2 CHGA SYP
37 carcinoid tumors, intestinal 10.2 CHGA SYP
38 respiratory system benign neoplasm 10.2 CHGA SYP
39 anterior cranial fossa meningioma 10.2 CHGA SYP
40 gastric squamous cell carcinoma 10.2 CHGA SYP
41 pulmonary blastoma 10.2 CHGA SYP
42 pleomorphic xanthoastrocytoma 10.2 CHGA SYP
43 tanycytic ependymoma 10.1 CHGA SYP
44 papillary ependymoma 10.1 CHGA SYP
45 non-functioning pancreatic endocrine tumor 10.1 CHGA SYP
46 central neurocytoma 10.1 CHGA SYP
47 binswanger's disease 10.1 CHGA SYP
48 carcinoid syndrome 10.1 CHGA SYP
49 cervix small cell carcinoma 10.1 CHGA SYP
50 cerebellar liponeurocytoma 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


fever, dyspnea, hemoptysis, coughing

MGI Mouse Phenotypes related to Pulmonary Large Cell Neuroendocrine Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 ALK CHGA KIF5B STK11 VGF
2 nervous system MP:0003631 9.02 ALK CHGA STK11 SYP VGF

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
4 Topoisomerase Inhibitors Phase 2
5 Etoposide phosphate Phase 2
6 Antimitotic Agents Phase 2
7 Albumin-Bound Paclitaxel Phase 2
8 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Unknown status NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

42
Lung, Brain, Prostate, Bronchial Epithelium

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 48)
# Title Authors Year
1
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. ( 30107896 )
2019
2
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase. ( 30591488 )
2019
3
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines. ( 30675274 )
2019
4
Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population-based analysis. ( 30734490 )
2019
5
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report. ( 30863102 )
2019
6
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
7
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
8
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
9
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
10
Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report. ( 30572435 )
2018
11
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
12
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
13
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2017
14
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
15
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )
2016
16
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )
2016
17
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )
2016
18
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )
2015
19
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )
2015
20
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )
2015
21
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )
2014
22
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )
2014
23
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )
2013
24
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )
2013
25
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )
2013
26
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )
2013
27
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )
2012
28
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )
2012
29
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )
2012
30
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )
2011
31
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )
2011
32
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )
2009
33
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )
2009
34
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )
2007
35
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )
2007
36
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )
2006
37
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )
2006
38
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )
2005
39
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )
2005
40
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )
2005
41
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )
2004
42
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )
2004
43
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )
2004
44
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )
2003
45
Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma. ( 26680943 )
2003
46
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )
2001
47
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )
2001
48
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Cellular components related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.13 CHGA SYP VGF
2 transport vesicle GO:0030133 8.62 CHGA VGF

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 8.96 STK11 VGF
2 hippocampus development GO:0021766 8.62 ALK KIF5B

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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