MCID: PLM038
MIFTS: 32

Pulmonary Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Pulmonary Large Cell Neuroendocrine Carcinoma:

Name: Pulmonary Large Cell Neuroendocrine Carcinoma 12 15
Large Cell Lung Neuroendocrine Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6658
NCIt 50 C5672 C6875
SNOMED-CT 68 128628002

Summaries for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards based summary : Pulmonary Large Cell Neuroendocrine Carcinoma, also known as large cell lung neuroendocrine carcinoma, is related to large cell neuroendocrine carcinoma and small cell carcinoma, and has symptoms including coughing, dyspnea and fever. An important gene associated with Pulmonary Large Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prostate.

Related Diseases for Pulmonary Large Cell Neuroendocrine Carcinoma

Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 30.2 CHGA ENO2 SYP
2 small cell carcinoma 29.2 CHGA ENO2 SYP
3 neuroendocrine tumor 29.0 CHGA ENO2 SYP
4 small cell cancer of the lung 29.0 CHGA ENO2 SYP
5 large cell carcinoma 27.2 CHGA ENO2 ROS1 STK11 SYP
6 lung cancer 26.9 CHGA ENO2 ROS1 STK11 SYP
7 esophageal neuroendocrine tumor 10.5 CHGA SYP
8 ovarian large-cell neuroendocrine carcinoma 10.5 CHGA SYP
9 adenoma of the pancreas 10.5 CHGA SYP
10 acinar cell cystadenocarcinoma 10.5 CHGA SYP
11 peritoneal serous adenocarcinoma 10.5 CHGA SYP
12 cellular ependymoma 10.5 CHGA SYP
13 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
14 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
15 chordoid meningioma 10.4 CHGA SYP
16 pancreatic serous cystadenoma 10.4 CHGA SYP
17 conventional angiosarcoma 10.4 CHGA SYP
18 pulmonary sclerosing hemangioma 10.4 CHGA SYP
19 pancreatoblastoma 10.4 CHGA SYP
20 pulmonary blastoma 10.4 CHGA SYP
21 ureter, cancer of 10.4 CHGA SYP
22 tanycytic ependymoma 10.4 CHGA SYP
23 non-functioning pancreatic endocrine tumor 10.4 CHGA SYP
24 pleomorphic xanthoastrocytoma 10.4 CHGA SYP
25 pancreatic cystadenocarcinoma 10.4 CHGA SYP
26 binswanger's disease 10.4 CHGA SYP
27 vaginal benign neoplasm 10.3 CHGA STK11
28 vaginal adenoma 10.3 CHGA STK11
29 vaginal tubulovillous adenoma 10.3 CHGA STK11
30 gastric tubular adenocarcinoma 10.3 CHGA SYP
31 breast papillary carcinoma 10.3 CHGA SYP
32 cystadenoma 10.3 CHGA SYP
33 primary pigmented nodular adrenocortical disease 10.2 CHGA SYP
34 cell type benign neoplasm 10.2 CHGA SYP
35 malignant sertoli cell tumor 10.1 ENO2 SYP
36 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
37 sensory organ benign neoplasm 10.1 ENO2 SYP
38 pancreatic somatostatinoma 10.1 ENO2 SYP
39 cutaneous ganglioneuroma 10.1 ENO2 SYP
40 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
41 papillary tumor of the pineal region 10.1 ENO2 SYP
42 orbital cancer 10.1 ENO2 SYP
43 middle ear adenoma 10.1 ENO2 SYP
44 ovarian carcinosarcoma 10.1 ENO2 SYP
45 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
46 cerebellum cancer 10.1 ENO2 SYP
47 subependymal glioma 10.1 ENO2 SYP
48 cerebral neuroblastoma 10.1 ENO2 SYP
49 extraosseous chondrosarcoma 10.1 ENO2 SYP
50 benign ependymoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma:



Diseases related to Pulmonary Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Pulmonary Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Pulmonary Large Cell Neuroendocrine Carcinoma:


coughing, dyspnea, fever, hemoptysis

Drugs & Therapeutics for Pulmonary Large Cell Neuroendocrine Carcinoma

Drugs for Pulmonary Large Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
4 Albumin-Bound Paclitaxel Phase 2
5 Topoisomerase Inhibitors Phase 2
6 Etoposide phosphate Phase 2
7 Antimitotic Agents Phase 2
8 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma Not yet recruiting NCT02943798 Phase 2 etoposide plus carboplatin;Paclitaxel plus carboplatin
2 Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC) Not yet recruiting NCT03305133

Search NIH Clinical Center for Pulmonary Large Cell Neuroendocrine Carcinoma

Genetic Tests for Pulmonary Large Cell Neuroendocrine Carcinoma

Anatomical Context for Pulmonary Large Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Pulmonary Large Cell Neuroendocrine Carcinoma:

41
Lung, Brain, Prostate, Bronchial Epithelium

Publications for Pulmonary Large Cell Neuroendocrine Carcinoma

Articles related to Pulmonary Large Cell Neuroendocrine Carcinoma:

(show all 42)
# Title Authors Year
1
Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration. ( 29271588 )
2018
2
Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? ( 29413048 )
2018
3
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review. ( 29765234 )
2018
4
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. ( 29066508 )
2018
5
Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature. ( 28943940 )
2017
6
Outcomes of Curative-Intent Surgery and Adjuvant Treatment for Pulmonary Large Cell Neuroendocrine Carcinoma. ( 28204910 )
2017
7
Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations. ( 28884744 )
2017
8
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
9
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma. ( 27368130 )
2016
10
Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401). ( 27903179 )
2016
11
PS01.24: Clinical Outcomes of Patients with Pulmonary Large Cell Neuroendocrine Carcinoma Characterized by Next-Generation Sequencing: Topic: Medical Oncology. ( 27969491 )
2016
12
Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases. ( 26176530 )
2015
13
Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy. ( 26039012 )
2015
14
Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma. ( 26060407 )
2015
15
Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. ( 25364438 )
2014
16
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. ( 24966991 )
2014
17
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. ( 22498090 )
2013
18
Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma. ( 24649189 )
2013
19
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. ( 23312550 )
2013
20
Tropomyosin-related kinase B inhibitor has potential for tumor regression and relapse prevention in pulmonary large cell neuroendocrine carcinoma. ( 24023298 )
2013
21
Prostatic metastasis of pulmonary large cell neuroendocrine carcinoma. ( 22359531 )
2012
22
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. ( 22400077 )
2012
23
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? ( 22579297 )
2012
24
Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. ( 22977617 )
2011
25
Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. ( 21918393 )
2011
26
Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. ( 20398190 )
2010
27
A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. ( 20082272 )
2009
28
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. ( 19619794 )
2009
29
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. ( 17706407 )
2007
30
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. ( 17643676 )
2007
31
Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. ( 16862075 )
2006
32
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. ( 17062251 )
2006
33
Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma. ( 15538626 )
2005
34
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. ( 16236978 )
2005
35
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. ( 15893001 )
2005
36
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. ( 15022286 )
2004
37
Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. ( 14719055 )
2004
38
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. ( 15172230 )
2004
39
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). ( 12694759 )
2003
40
Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. ( 11391577 )
2001
41
High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma. ( 11505281 )
2001
42
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. ( 7973914 )
1994

Variations for Pulmonary Large Cell Neuroendocrine Carcinoma

Expression for Pulmonary Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Pulmonary Large Cell Neuroendocrine Carcinoma.

Pathways for Pulmonary Large Cell Neuroendocrine Carcinoma

GO Terms for Pulmonary Large Cell Neuroendocrine Carcinoma

Biological processes related to Pulmonary Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell growth GO:0001558 8.62 ROS1 STK11

Sources for Pulmonary Large Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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