MCID: PLM039
MIFTS: 31

Pulmonary Neuroendocrine Tumor

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

MalaCards integrated aliases for Pulmonary Neuroendocrine Tumor:

Name: Pulmonary Neuroendocrine Tumor 12 15 17
Neuroendocrine Neoplasm of Lung 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5410
NCIt 50 C5670
SNOMED-CT 67 707594002
UMLS 71 C1334452

Summaries for Pulmonary Neuroendocrine Tumor

MalaCards based summary : Pulmonary Neuroendocrine Tumor, also known as neuroendocrine neoplasm of lung, is related to acromegaly and neuroendocrine carcinoma. An important gene associated with Pulmonary Neuroendocrine Tumor is CHGA (Chromogranin A), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Everolimus and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include lung and pancreas, and related phenotype is nervous system.

Wikipedia : 74 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

Related Diseases for Pulmonary Neuroendocrine Tumor

Diseases related to Pulmonary Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 acromegaly 29.5 SSTR5 SSTR2 SST MEN1
2 neuroendocrine carcinoma 29.4 SYP SST NKX2-1 NCAM1 ENO2 CHGA
3 large cell carcinoma 29.3 SYP NKX2-1 NCAM1 ENO2 CHGA
4 large cell neuroendocrine carcinoma 29.3 SYP NKX2-1 NCAM1 ENO2 DLL3 CHGA
5 carcinoid syndrome 29.3 SYP SST MEN1 ENO2 CHGA
6 neuroendocrine tumor 29.1 SYP SSTR2 SST NKX2-1 NCAM1 MEN1
7 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
8 acinar cell cystadenocarcinoma 10.4 SYP CHGA
9 vulvar eccrine porocarcinoma 10.4 SYP CHGA
10 vaginal tubulovillous adenoma 10.4 SYP CHGA
11 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
12 breast papillary carcinoma 10.4 SYP CHGA
13 appendix adenocarcinoma 10.4 SYP CHGA
14 rectum neuroendocrine neoplasm 10.4 SYP SST
15 lung combined type small cell carcinoma 10.4 SYP NCAM1
16 ectopic cushing syndrome 10.4 SST CHGA
17 glucagonoma 10.4 SST CHGA
18 hypoganglionosis 10.4 SYP NCAM1
19 glomangiosarcoma 10.4 SYP NCAM1
20 vaginal adenoma 10.4 SYP CHGA
21 vaginal benign neoplasm 10.4 SYP CHGA
22 extra-adrenal pheochromocytoma 10.4 SYP CHGA
23 pancreatic acinar cell adenocarcinoma 10.4 SYP CHGA
24 biliary tract benign neoplasm 10.3 SYP NCAM1
25 prostate stromal sarcoma 10.3 SYP NCAM1
26 thymus basaloid carcinoma 10.3 SYP NKX2-1
27 ureteral benign neoplasm 10.3 SYP NKX2-1
28 ovarian germ cell teratoma 10.3 SYP NKX2-1
29 duodenal benign neoplasm 10.3 SYP SST CHGA
30 binswanger's disease 10.3 SYP SST CHGA
31 meckel diverticulum 10.3 SYP SST CHGA
32 adrenal medulla cancer 10.3 SYP SST CHGA
33 esophageal neuroendocrine tumor 10.3 SYP NCAM1 CHGA
34 pancreatoblastoma 10.3 SYP SST CHGA
35 lung leiomyosarcoma 10.3 SYP NKX2-1
36 pancreatic serous cystadenocarcinoma 10.3 SYP NCAM1 CHGA
37 papillary thymic adenocarcinoma 10.3 SYP NCAM1 CHGA
38 intrahepatic bile duct adenoma 10.3 NCAM1 CHGA
39 esophageal adenoid cystic carcinoma 10.3 SYP NCAM1 CHGA
40 glomangiomatosis 10.3 SYP NCAM1 CHGA
41 type c thymoma 10.3 SSTR2 SST
42 chordoid meningioma 10.3 SYP NCAM1 CHGA
43 keratinizing squamous cell carcinoma 10.3 SYP NKX2-1
44 clear cell meningioma 10.3 SYP CHGA
45 papillary ependymoma 10.3 SYP MEN1
46 papillary adenoma 10.3 SYP NKX2-1
47 tanycytic ependymoma 10.2 SYP MEN1
48 duodenal somatostatinoma 10.2 SST MEN1
49 chordoid glioma 10.2 SYP NKX2-1
50 pituitary infarct 10.2 SST MEN1

Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to Pulmonary Neuroendocrine Tumor

Symptoms & Phenotypes for Pulmonary Neuroendocrine Tumor

MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 ASCL1 CHGA DLL3 ENO2 MEN1 NCAM1

Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

Drugs for Pulmonary Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177 70789204
2
Lactitol Approved, Investigational Phase 1, Phase 2 585-86-4 157355
3 Immunosuppressive Agents Phase 1, Phase 2
4 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase Ib, Open-label Study to Evaluate RAD001 as Monotherapy Treatment in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Unknown status NCT01175096 Phase 1, Phase 2 RAD001 (everolimus, Afinitor®)
2 A Phase Ib, Open-label Study to Evaluate RAD001 as Monotherapy Treatment in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Completed NCT01324492 Phase 1 RAD001
3 Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

Anatomical Context for Pulmonary Neuroendocrine Tumor

MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

40
Lung, Pancreas

Publications for Pulmonary Neuroendocrine Tumor

Articles related to Pulmonary Neuroendocrine Tumor:

(show all 37)
# Title Authors PMID Year
1
Proposal of organ-specific subdivision of M component and staging system for metastatic pulmonary neuroendocrine tumor. 61
32846318 2020
2
Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment. 61
32748870 2020
3
Pulmonary Neuroendocrine Tumor Presenting as a Left Pleural Effusion. 61
32669783 2020
4
Imaging Characteristics of Coexisting Primary Pulmonary Carcinoid Tumor and Multiple Myeloma on 18F-FDG and 68Ga-DOTATATE PET/CT. 61
31306189 2019
5
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. 61
31324758 2019
6
Clinical significance of progastrin-releasing peptide, neuron-specific enolase, chromogranin a, and squamous cell cancer antigen in pulmonary neuroendocrine tumors 61
31091854 2019
7
Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors. 61
30807354 2019
8
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. 61
30107896 2019
9
[Systemic Therapy for Low-grade Pulmonary Neuroendocrine Tumor]. 61
30674391 2019
10
Predictive factors of postoperative survival among patients with pulmonary neuroendocrine tumor. 61
30746237 2018
11
Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma. 61
30693127 2018
12
[Cyclical Cushing syndrome due to pulmonary neuroendocrine tumor: a case report]. 61
29202538 2017
13
A major procalcitonin elevation without sepsis in a metastatic small cell lung carcinoma. 61
28958968 2017
14
Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report. 61
28834902 2017
15
Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors. 61
28621224 2017
16
Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus). 61
28190820 2017
17
ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. 61
27452466 2016
18
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature. 61
27349224 2016
19
Neuroendocrine Cancer of the Lung: A Diagnostic Puzzle. 61
26723240 2016
20
[Update of pathological diagnosis of pulmonary neuroendocrine tumor]. 61
27045239 2016
21
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. 61
26311731 2015
22
Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. 61
26798346 2015
23
Pulmonary neuroendocrine tumors with nuclear inclusion. 61
23896262 2013
24
[Paraneoplastic manifestation of pulmonary neuroendocrine tumor]. 61
23294639 2013
25
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. 61
23446117 2013
26
Clinical course of neuroendocrine tumors with different origins (the pancreas, gastrointestinal tract, and lung). 61
21659833 2012
27
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. 61
22391733 2012
28
¹⁸F-FDG uptake on PET could be a predictive marker of excision repair cross-complementation group 1 (ERCC1) expression in patients with thoracic neoplasms? 61
22329847 2012
29
Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors. 61
21785870 2011
30
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. 61
20195926 2010
31
Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. 61
19424611 2009
32
Difficulties in diagnosis and management of ectopic Cushing syndrome. 61
18379368 2008
33
Large cell neuroendocrine carcinoma of the mediastinum with alpha-fetoprotein production. 61
18303442 2008
34
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? 61
16699304 2006
35
Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. 61
16418242 2006
36
A case of Lambert-Eaton myasthenic syndrome associated with atypical bronchopulmonary carcinoid tumor. 61
15483357 2004
37
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. 61
2866833 1986

Variations for Pulmonary Neuroendocrine Tumor

Expression for Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for Pulmonary Neuroendocrine Tumor

Pathways related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP NKX2-1 NCAM1 ENO2
2 10.7 SYP NCAM1 ASCL1

GO Terms for Pulmonary Neuroendocrine Tumor

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to glucocorticoid stimulus GO:0071385 9.26 SSTR5 SSTR2
2 somatostatin signaling pathway GO:0038170 9.16 SSTR5 SSTR2
3 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 NKX2-1 ASCL1
4 forebrain neuron differentiation GO:0021879 8.8 OTP NKX2-1 ASCL1

Molecular functions related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide binding GO:0042923 8.96 SSTR5 SSTR2
2 somatostatin receptor activity GO:0004994 8.62 SSTR5 SSTR2

Sources for Pulmonary Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....