MCID: PLM039
MIFTS: 31

Pulmonary Neuroendocrine Tumor

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

MalaCards integrated aliases for Pulmonary Neuroendocrine Tumor:

Name: Pulmonary Neuroendocrine Tumor 12 15
Neuroendocrine Neoplasm of Lung 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5410
NCIt 50 C5670
UMLS 73 C1334452

Summaries for Pulmonary Neuroendocrine Tumor

MalaCards based summary : Pulmonary Neuroendocrine Tumor, also known as neuroendocrine neoplasm of lung, is related to neuroendocrine tumor and leukemia. An important gene associated with Pulmonary Neuroendocrine Tumor is DLL3 (Delta Like Canonical Notch Ligand 3), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Everolimus and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

Related Diseases for Pulmonary Neuroendocrine Tumor

Diseases related to Pulmonary Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.3
2 leukemia 9.8
3 conn's syndrome 9.8
4 acromegaly 9.8
5 cowden disease 9.8
6 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 9.8
7 adenoid cystic carcinoma 9.6 BCOR NFIB

Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to Pulmonary Neuroendocrine Tumor

Symptoms & Phenotypes for Pulmonary Neuroendocrine Tumor

GenomeRNAi Phenotypes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.36 NFIB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.36 NFIB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 BCOR NFIB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.36 BCOR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.36 BCOR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 BCOR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.36 BCOR NFIB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.36 NFIB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.36 BCOR

MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ASCL1 BCOR DLL3 NEUROD1 NFIB
2 mortality/aging MP:0010768 9.55 ASCL1 BCOR DLL3 NEUROD1 NFIB
3 nervous system MP:0003631 9.35 ASCL1 BCOR DLL3 NEUROD1 NFIB
4 vision/eye MP:0005391 8.92 ASCL1 DLL3 NEUROD1 NFIB

Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

Drugs for Pulmonary Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
2
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
5 Anti-Infective Agents Phase 1, Phase 2
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Immunosuppressive Agents Phase 1, Phase 2
8 Antifungal Agents Phase 1, Phase 2
9 Antibiotics, Antitubercular Phase 1, Phase 2
10 Immunologic Factors Phase 1, Phase 2
11
Pasireotide Approved Phase 1 396091-73-9 9941444
12
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
13 Hormone Antagonists Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
15 Hormones Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Tolerability Profile of RAD001 Daily in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Unknown status NCT01175096 Phase 1, Phase 2 RAD001 (everolimus, Afinitor®)
2 Safety and Efficacy of RAD001 in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Completed NCT01324492 Phase 1 RAD001
3 Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs Completed NCT01263353 Phase 1 Pasireotide LAR followed by Pasireotide LAR + Everolimus;Everolimus followed by Pasireotide LAR + Everolimus
4 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

Anatomical Context for Pulmonary Neuroendocrine Tumor

MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

41
Lung

Publications for Pulmonary Neuroendocrine Tumor

Articles related to Pulmonary Neuroendocrine Tumor:

# Title Authors Year
1
Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus). ( 28190820 )
2017
2
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature. ( 27349224 )
2016
3
Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. ( 26798346 )
2015
4
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. ( 26311731 )
2015
5
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. ( 23446117 )
2013
6
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. ( 22391733 )
2012
7
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. ( 20195926 )
2010
8
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? ( 16699304 )
2006
9
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. ( 2866833 )
1986

Variations for Pulmonary Neuroendocrine Tumor

Expression for Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for Pulmonary Neuroendocrine Tumor

GO Terms for Pulmonary Neuroendocrine Tumor

Cellular components related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.62 ASCL1 NEUROD1

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 ASCL1 NEUROD1 NFIB
2 multicellular organism development GO:0007275 9.63 ASCL1 DLL3 NEUROD1
3 cell differentiation GO:0030154 9.61 ASCL1 DLL3 NEUROD1
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.58 ASCL1 BCOR NFIB
5 Notch signaling pathway GO:0007219 9.37 ASCL1 DLL3
6 positive regulation of neuron differentiation GO:0045666 9.32 ASCL1 NEUROD1
7 neuron development GO:0048666 9.26 ASCL1 NEUROD1
8 neurogenesis GO:0022008 9.16 ASCL1 NEUROD1
9 hindbrain development GO:0030902 8.96 NEUROD1 NFIB
10 glial cell differentiation GO:0010001 8.62 ASCL1 NFIB

Molecular functions related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.43 ASCL1 NEUROD1 NFIB
2 protein dimerization activity GO:0046983 9.32 ASCL1 NEUROD1
3 E-box binding GO:0070888 9.16 ASCL1 NEUROD1
4 transcription factor binding GO:0008134 9.13 ASCL1 BCOR NEUROD1
5 double-stranded DNA binding GO:0003690 8.8 ASCL1 NEUROD1 NFIB

Sources for Pulmonary Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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