MCID: PLM039
MIFTS: 30

Pulmonary Neuroendocrine Tumor

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

MalaCards integrated aliases for Pulmonary Neuroendocrine Tumor:

Name: Pulmonary Neuroendocrine Tumor 12 15 17
Neuroendocrine Neoplasm of Lung 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5410
NCIt 49 C5670
SNOMED-CT 67 707594002
UMLS 71 C1334452

Summaries for Pulmonary Neuroendocrine Tumor

MalaCards based summary : Pulmonary Neuroendocrine Tumor, also known as neuroendocrine neoplasm of lung, is related to small cell carcinoma and large cell neuroendocrine carcinoma. An important gene associated with Pulmonary Neuroendocrine Tumor is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways are Neuroscience and Neural Stem Cells and Lineage-specific Markers. The drugs Everolimus and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and pancreas, and related phenotype is nervous system.

Wikipedia : 74 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

Related Diseases for Pulmonary Neuroendocrine Tumor

Diseases related to Pulmonary Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 29.8 SYP NKX2-1 NCAM1 ENO2 CHGA
2 large cell neuroendocrine carcinoma 29.7 SYP NKX2-1 NCAM1 ENO2 CHGA ASCL1
3 acromegaly 29.6 SSTR2 SST MEN1
4 large cell carcinoma 29.5 SYP NKX2-1 NCAM1 ENO2 CHGA
5 lung benign neoplasm 29.1 SYP NKX2-1 NCAM1 ENO2 CHGA
6 neuroendocrine carcinoma 28.9 SYP SST NKX2-1 NCAM1 MEN1 ENO2
7 neuroendocrine tumor 28.4 SYP SSTR2 SST NKX2-1 NCAM1 MEN1
8 carcinoid tumors, intestinal 28.2 SYP SSTR2 SST NKX2-1 MEN1 ENO2
9 small cell cancer of the lung 27.8 SYP SSTR2 SST NKX2-1 NCAM1 ENO2
10 primary hepatic neuroendocrine carcinoma 10.5 SYP CHGA
11 acinar cell cystadenocarcinoma 10.5 SYP CHGA
12 vulvar eccrine porocarcinoma 10.5 SYP CHGA
13 cervical large cell neuroendocrine carcinoma 10.5 SYP CHGA
14 mixed ductal-endocrine carcinoma 10.5 SYP CHGA
15 appendiceal neoplasm 10.5 SPINK5 CHGA
16 vaginal tubulovillous adenoma 10.5 SYP CHGA
17 breast papillary carcinoma 10.5 SYP CHGA
18 rectum neuroendocrine neoplasm 10.5 SYP SST
19 lung combined type small cell carcinoma 10.5 SYP NCAM1
20 appendix adenocarcinoma 10.5 SYP CHGA
21 tricuspid valve stenosis 10.5 SST SPINK5
22 glucagonoma 10.5 SST CHGA
23 hypoganglionosis 10.5 SYP NCAM1
24 vaginal adenoma 10.5 SYP CHGA
25 glomangiosarcoma 10.5 SYP NCAM1
26 pancreatic acinar cell adenocarcinoma 10.4 SYP CHGA
27 vaginal benign neoplasm 10.4 SYP CHGA
28 extra-adrenal pheochromocytoma 10.4 SYP CHGA
29 ectopic cushing syndrome 10.4 SYP SST
30 thymus basaloid carcinoma 10.4 SPINK5 NKX2-1
31 lung meningioma 10.4 SYP NKX2-1
32 prostate stromal sarcoma 10.4 SYP NCAM1
33 cecal disease 10.4 SYP SPINK5 CHGA
34 meckel diverticulum 10.4 SST SPINK5 CHGA
35 ovarian germ cell teratoma 10.3 SYP NKX2-1
36 binswanger's disease 10.3 SYP SST CHGA
37 clear cell meningioma 10.3 SYP CHGA
38 adrenal medulla cancer 10.3 SYP SST CHGA
39 pancreatoblastoma 10.3 SYP SST CHGA
40 type c thymoma 10.3 SSTR2 SST
41 pancreatic serous cystadenocarcinoma 10.3 SYP NCAM1 CHGA
42 papillary thymic adenocarcinoma 10.3 SYP NCAM1 CHGA
43 laryngeal neuroendocrine tumor 10.3 SYP NCAM1 CHGA
44 esophageal adenoid cystic carcinoma 10.3 SYP NCAM1 CHGA
45 pulmonary large cell neuroendocrine carcinoma 10.3 SYP NCAM1 CHGA
46 chordoid meningioma 10.3 SYP NCAM1 CHGA
47 tsh producing pituitary tumor 10.3 SSTR2 SST
48 glomangiomatosis 10.3 SYP NCAM1 CHGA
49 functionless pituitary adenoma 10.3 SSTR2 SST
50 cerebral lymphoma 10.3 SSTR2 SST

Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to Pulmonary Neuroendocrine Tumor

Symptoms & Phenotypes for Pulmonary Neuroendocrine Tumor

MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 ASCL1 CHGA DLL3 ENO2 MEN1 NCAM1

Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

Drugs for Pulmonary Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
2
Lactitol Approved, Investigational Phase 1, Phase 2 585-88-6, 585-86-4 493591
3 Immunosuppressive Agents Phase 1, Phase 2
4 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase Ib, Open-label Study to Evaluate RAD001 as Monotherapy Treatment in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Unknown status NCT01175096 Phase 1, Phase 2 RAD001 (everolimus, Afinitor®)
2 A Phase Ib, Open-label Study to Evaluate RAD001 as Monotherapy Treatment in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Completed NCT01324492 Phase 1 RAD001
3 Inpatient Hospice With Procurement of Tissue on Expiration in Thoracic Malignancies,Bladder Cancer and Patients Treated With an Adoptive Cellular Therapy Recruiting NCT01851395

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

Anatomical Context for Pulmonary Neuroendocrine Tumor

MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

40
Lung, Brain, Pancreas

Publications for Pulmonary Neuroendocrine Tumor

Articles related to Pulmonary Neuroendocrine Tumor:

(show all 34)
# Title Authors PMID Year
1
Imaging Characteristics of Coexisting Primary Pulmonary Carcinoid Tumor and Multiple Myeloma on 18F-FDG and 68Ga-DOTATATE PET/CT. 61
31306189 2019
2
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. 61
31324758 2019
3
Clinical significance of progastrin-releasing peptide, neuron-specific enolase, chromogranin a, and squamous cell cancer antigen in pulmonary neuroendocrine tumors 61
31091854 2019
4
Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors. 61
30807354 2019
5
Treatment outcomes and incidence of brain metastases in pulmonary large cell neuroendocrine carcinoma. 61
30107896 2019
6
[Systemic Therapy for Low-grade Pulmonary Neuroendocrine Tumor]. 61
30674391 2019
7
Predictive factors of postoperative survival among patients with pulmonary neuroendocrine tumor. 61
30746237 2018
8
Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma. 61
30693127 2018
9
[Cyclical Cushing syndrome due to pulmonary neuroendocrine tumor: a case report]. 61
29202538 2017
10
A major procalcitonin elevation without sepsis in a metastatic small cell lung carcinoma. 61
28958968 2017
11
Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report. 61
28834902 2017
12
Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors. 61
28621224 2017
13
Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus). 61
28190820 2017
14
ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. 61
27452466 2016
15
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature. 61
27349224 2016
16
Neuroendocrine Cancer of the Lung: A Diagnostic Puzzle. 61
26723240 2016
17
[Update of pathological diagnosis of pulmonary neuroendocrine tumor]. 61
27045239 2016
18
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. 61
26311731 2015
19
Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. 61
26798346 2015
20
Pulmonary neuroendocrine tumors with nuclear inclusion. 61
23896262 2013
21
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. 61
23446117 2013
22
[Paraneoplastic manifestation of pulmonary neuroendocrine tumor]. 61
23294639 2013
23
Clinical course of neuroendocrine tumors with different origins (the pancreas, gastrointestinal tract, and lung). 61
21659833 2012
24
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. 61
22391733 2012
25
¹⁸F-FDG uptake on PET could be a predictive marker of excision repair cross-complementation group 1 (ERCC1) expression in patients with thoracic neoplasms? 61
22329847 2012
26
Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors. 61
21785870 2011
27
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. 61
20195926 2010
28
Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. 61
19424611 2009
29
Difficulties in diagnosis and management of ectopic Cushing syndrome. 61
18379368 2008
30
Large cell neuroendocrine carcinoma of the mediastinum with alpha-fetoprotein production. 61
18303442 2008
31
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? 61
16699304 2006
32
Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. 61
16418242 2006
33
A case of Lambert-Eaton myasthenic syndrome associated with atypical bronchopulmonary carcinoid tumor. 61
15483357 2004
34
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. 61
2866833 1986

Variations for Pulmonary Neuroendocrine Tumor

Expression for Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for Pulmonary Neuroendocrine Tumor

Pathways related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP NKX2-1 NCAM1 ENO2
2 10.7 SYP NCAM1 ASCL1

GO Terms for Pulmonary Neuroendocrine Tumor

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 NKX2-1 ASCL1
2 forebrain neuron differentiation GO:0021879 8.8 OTP NKX2-1 ASCL1

Sources for Pulmonary Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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