MCID: PLM039
MIFTS: 36

Pulmonary Neuroendocrine Tumor

Categories: Cancer diseases, Respiratory diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Neuroendocrine Tumor

MalaCards integrated aliases for Pulmonary Neuroendocrine Tumor:

Name: Pulmonary Neuroendocrine Tumor 12 15
Neuroendocrine Neoplasm of Lung 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5410
NCIt 50 C5670
SNOMED-CT 68 707594002
UMLS 73 C1334452

Summaries for Pulmonary Neuroendocrine Tumor

MalaCards based summary : Pulmonary Neuroendocrine Tumor, also known as neuroendocrine neoplasm of lung, is related to neuroendocrine tumor and leukemia. An important gene associated with Pulmonary Neuroendocrine Tumor is DLL3 (Delta Like Canonical Notch Ligand 3), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Pulmonary neuroendocrine tumors are neuroendocrine tumors localized to the lung: bronchus or pulmonary... more...

Related Diseases for Pulmonary Neuroendocrine Tumor

Diseases related to Pulmonary Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.4
2 leukemia 9.7
3 conn's syndrome 9.7
4 acromegaly 9.7
5 cowden disease 9.7
6 thyroiditis 9.7
7 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 9.7

Graphical network of the top 20 diseases related to Pulmonary Neuroendocrine Tumor:



Diseases related to Pulmonary Neuroendocrine Tumor

Symptoms & Phenotypes for Pulmonary Neuroendocrine Tumor

GenomeRNAi Phenotypes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.4 NFIB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 NFIB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.4 BCOR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 BCOR NFIB
5 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.4 BCOR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.4 BCOR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.4 BCOR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.4 BCOR NFIB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.4 NFIB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.4 BCOR

MGI Mouse Phenotypes related to Pulmonary Neuroendocrine Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 NEUROD1 NFIB ASCL1 BCOR DLL3
2 mortality/aging MP:0010768 9.55 NEUROD1 NFIB ASCL1 BCOR DLL3
3 nervous system MP:0003631 9.35 NFIB ASCL1 BCOR DLL3 NEUROD1
4 vision/eye MP:0005391 8.92 NFIB ASCL1 DLL3 NEUROD1

Drugs & Therapeutics for Pulmonary Neuroendocrine Tumor

Drugs for Pulmonary Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
Gemcitabine Approved Phase 2 95058-81-4 60750
6
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
7
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
8
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
9
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
10
Fluorouracil Approved Phase 2 51-21-8 3385
11
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
12
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
14
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
15 Anti-Bacterial Agents Phase 1, Phase 2,Phase 2
16 Antibiotics, Antitubercular Phase 1, Phase 2,Phase 2
17 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
18 Anti-Infective Agents Phase 1, Phase 2,Phase 2
19 Antifungal Agents Phase 1, Phase 2
20 Alkylating Agents Phase 2
21 Micronutrients Phase 2
22 Hematinics Phase 2
23 Trace Elements Phase 2
24 Vitamin B Complex Phase 2
25 Vitamins Phase 2
26 Antidotes Phase 2
27 Protective Agents Phase 2
28 Antimetabolites Phase 2
29 Antiviral Agents Phase 2
30 Antimetabolites, Antineoplastic Phase 2
31 Antineoplastic Agents, Alkylating Phase 2
32 Folate Nutraceutical Phase 2
33 Vitamin B9 Nutraceutical Phase 2
34
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
35 Hormone Antagonists Phase 1
36 Hormones Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Tolerability Profile of RAD001 Daily in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Unknown status NCT01175096 Phase 1, Phase 2 RAD001 (everolimus, Afinitor®)
2 O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents and Interest of Oxaliplatin in Patients With Unmethylated MGMT NET. Not yet recruiting NCT03217097 Phase 2 Oxaliplatin-based chemotherapy;Alkylating-based chemotherapy
3 Safety and Efficacy of RAD001 in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor Completed NCT01324492 Phase 1 RAD001
4 Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs Completed NCT01263353 Phase 1 Pasireotide LAR followed by Pasireotide LAR + Everolimus;Everolimus followed by Pasireotide LAR + Everolimus
5 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170

Search NIH Clinical Center for Pulmonary Neuroendocrine Tumor

Genetic Tests for Pulmonary Neuroendocrine Tumor

Anatomical Context for Pulmonary Neuroendocrine Tumor

MalaCards organs/tissues related to Pulmonary Neuroendocrine Tumor:

41
Lung, Fetal Lung, Thyroid, Lymph Node

Publications for Pulmonary Neuroendocrine Tumor

Articles related to Pulmonary Neuroendocrine Tumor:

(show all 28)
# Title Authors Year
1
Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus). ( 28190820 )
2017
2
Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors. ( 28621224 )
2017
3
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature. ( 27349224 )
2016
4
Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. ( 26798346 )
2015
5
Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors. ( 25722034 )
2015
6
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. ( 26311731 )
2015
7
Carbonic anhydrase II mediates malignant behavior of pulmonary neuroendocrine tumors. ( 25019941 )
2015
8
Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study. ( 23416030 )
2013
9
Pulmonary neuroendocrine tumor incidentally detected by (18)F-CH PET/CT. ( 23446117 )
2013
10
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT. ( 22391733 )
2012
11
Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors. ( 22924844 )
2012
12
Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors. ( 21785870 )
2011
13
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. ( 21750865 )
2011
14
[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]. ( 20677557 )
2010
15
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. ( 20195926 )
2010
16
Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. ( 19424611 )
2009
17
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. ( 18281538 )
2008
18
Immunohistochemical expression of estrogen and progesterone receptors in primary pulmonary neuroendocrine tumors. ( 19061285 )
2008
19
Telomere length, telomerase activity, and expressions of human telomerase mRNA component (hTERC) and human telomerase reverse transcriptase (hTERT) mRNA in pulmonary neuroendocrine tumors. ( 17060405 )
2007
20
Long-term quiescence of ectopic Cushing's syndrome caused by pulmonary neuroendocrine tumor (typical carcinoid) and tumorlets: spontaneous remission or therapeutic effect of bromocriptine? ( 16699304 )
2006
21
Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. ( 15712207 )
2005
22
hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. ( 14657947 )
2004
23
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. ( 15492986 )
2004
24
Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. ( 15154011 )
2004
25
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia as a precursor to pulmonary neuroendocrine tumors. ( 15136447 )
2004
26
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. ( 9950155 )
1999
27
Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome. ( 8623922 )
1996
28
Immunoreactive somatostatin and calcitonin in pulmonary neuroendocrine tumor. ( 2866833 )
1986

Variations for Pulmonary Neuroendocrine Tumor

Expression for Pulmonary Neuroendocrine Tumor

Search GEO for disease gene expression data for Pulmonary Neuroendocrine Tumor.

Pathways for Pulmonary Neuroendocrine Tumor

GO Terms for Pulmonary Neuroendocrine Tumor

Cellular components related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.62 ASCL1 NEUROD1

Biological processes related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.76 ASCL1 BCOR NEUROD1 NFIB
2 transcription, DNA-templated GO:0006351 9.73 ASCL1 BCOR NEUROD1 NFIB
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.67 ASCL1 NEUROD1 NFIB
4 cell differentiation GO:0030154 9.65 ASCL1 DLL3 NEUROD1
5 negative regulation of transcription by RNA polymerase II GO:0000122 9.58 ASCL1 BCOR NFIB
6 Notch signaling pathway GO:0007219 9.37 ASCL1 DLL3
7 positive regulation of neuron differentiation GO:0045666 9.32 ASCL1 NEUROD1
8 neurogenesis GO:0022008 9.26 ASCL1 NEUROD1
9 neuron development GO:0048666 9.16 ASCL1 NEUROD1
10 hindbrain development GO:0030902 8.96 NEUROD1 NFIB
11 glial cell differentiation GO:0010001 8.62 ASCL1 NFIB

Molecular functions related to Pulmonary Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 9.16 ASCL1 NEUROD1
2 E-box binding GO:0070888 8.96 ASCL1 NEUROD1
3 double-stranded DNA binding GO:0003690 8.8 ASCL1 NEUROD1 NFIB

Sources for Pulmonary Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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