MCID: PLM012
MIFTS: 57

Pulmonary Sarcoidosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sarcoidosis

MalaCards integrated aliases for Pulmonary Sarcoidosis:

Name: Pulmonary Sarcoidosis 38 12 15
Sarcoidosis, Pulmonary 76 44 73
Sarcoidosis Pulmonary 55
Lung Sarcoidosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13406
ICD10 33 D86.0 D86.2
MeSH 44 D017565
NCIt 50 C34997
SNOMED-CT 68 187230004 24369008
UMLS 73 C0036205

Summaries for Pulmonary Sarcoidosis

MalaCards based summary : Pulmonary Sarcoidosis, also known as sarcoidosis, pulmonary, is related to chronic beryllium disease and bronchiolitis obliterans. An important gene associated with Pulmonary Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azathioprine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as... more...

Related Diseases for Pulmonary Sarcoidosis

Diseases related to Pulmonary Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 chronic beryllium disease 30.4 IFNG TNF
2 bronchiolitis obliterans 30.3 CXCR3 IFNG TNF
3 bronchiolitis 30.1 CCL5 IFNG TNF
4 crescentic glomerulonephritis 30.0 CCL2 CCR5 ICAM1
5 vasculitis 29.9 CCL2 ICAM1 TNF
6 pneumonia 29.7 CCL2 CCL5 SFTPD TNF
7 lymphopenia 29.4 IFNG IL2 IL2RA
8 respiratory failure 29.2 ACE SFTPD TNF
9 interstitial lung disease 28.7 CCL2 CCL5 IFNG SFTPD TNF
10 pleurisy 28.7 CCL2 ICAM1 IFNG IL2 TNF
11 lung disease 28.6 CCL2 CCL5 CSF2 SFTPD TNF
12 colitis 28.6 IFNG IL2 TNF
13 extrinsic allergic alveolitis 28.5 CCL2 CCL5 CXCR3 IL2RA SFTPD
14 pulmonary tuberculosis 28.5 IFNG IL18 IL2 TNF
15 arthritis 28.3 CCL2 CSF2 IFNG IL18 TNF
16 pulmonary fibrosis, idiopathic 26.8 CCL2 CCL5 CXCL5 CXCR3 IFNG IL18
17 multiple sclerosis 26.8 CCL2 CCL5 CCR5 CXCR3 ICAM1 IFNG
18 psoriasis 26.3 CCL2 CCL5 CXCR3 ICAM1 IFNG IL18
19 systemic lupus erythematosus 25.9 CCL2 CCL5 CXCR3 ICAM1 IFNG IL18
20 rheumatoid arthritis 24.6 CCL2 CCL5 CSF2 CXCL5 ICAM1 IFNG
21 sarcoidosis 1 24.0 ACE CCL2 CCL5 CXCL5 CXCR3 ICAM1
22 staphylococcal toxic shock syndrome 10.9 IFNG TNF
23 scorpion envenomation 10.8 CCL5 TNF
24 hyperlucent lung 10.7 IFNG IL2RA
25 herpes simplex virus keratitis 10.7 CCL2 ICAM1
26 african tick-bite fever 10.7 CCL5 IFNG
27 whiplash 10.7 CCL5 CCR5
28 anthracosis 10.6 CCL2 TNF
29 poliomyelitis 10.6 ICAM1 IFNG TNF
30 plasmodium vivax malaria 10.6 ICAM1 IFNG TNF
31 ileocolitis 10.6 IL2RA TNF
32 toxoplasmosis 10.6 CCR5 IFNG TNF
33 proliferative glomerulonephritis 10.6 CCL2 CXCR3 IFNG
34 spotted fever 10.6 CCL5 IFNG TNF
35 subacute cutaneous lupus erythematosus 10.5 ACE TNF
36 helicobacter pylori infection 10.5 CCL5 IFNG TNF
37 meningitis 10.5 CCL2 IFNG TNF
38 secondary progressive multiple sclerosis 10.5 CCL2 CCR5 CXCR3
39 oral tuberculosis 10.5 IL2 TNF
40 periodontitis 10.5 CCL2 IFNG TNF
41 skin sarcoidosis 10.5 ACE TNF
42 chronic eosinophilic pneumonia 10.5 CCL5 CXCR3 ICAM1
43 central nervous system disease 10.5 CXCR3 IFNG TNF
44 autoimmune enteropathy 10.5 ICAM1 IL2RA
45 scleritis 10.5 CCL2 TNF
46 vernal keratoconjunctivitis 10.5 CCL5 CXCR3 ICAM1
47 alcoholic hepatitis 10.5 CCL2 ICAM1 TNF
48 viral meningitis 10.5 CCL2 CCL5 IFNG
49 wegener granulomatosis 10.5 CCR5 IFNG TNF
50 mucocutaneous leishmaniasis 10.5 CCR5 TNF

Graphical network of the top 20 diseases related to Pulmonary Sarcoidosis:



Diseases related to Pulmonary Sarcoidosis

Symptoms & Phenotypes for Pulmonary Sarcoidosis

GenomeRNAi Phenotypes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE ICAM1 IL18 IL2 IL2RA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ACE ICAM1 IL18 IL2 IL2RA TNF

MGI Mouse Phenotypes related to Pulmonary Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 IL2RA SFTPD TNF IL2 ACE ICAM1
2 immune system MP:0005387 10.13 IL2RA SFTPD TNF ACE ICAM1 CCL2
3 cardiovascular system MP:0005385 10.11 TNF IL2 CXCR3 ACE ICAM1 CCR5
4 homeostasis/metabolism MP:0005376 10.11 IL2RA SFTPD TNF IL2 CXCR3 ACE
5 mortality/aging MP:0010768 10 IL2 IL2RA SFTPD TNF CXCR3 ACE
6 digestive/alimentary MP:0005381 9.98 IL2 IL2RA TNF ICAM1 CCR5 IFNG
7 neoplasm MP:0002006 9.76 TNF IL2 ACE ICAM1 CCR5 IFNG
8 respiratory system MP:0005388 9.5 IL2 IL2RA SFTPD TNF CXCR3 IFNG
9 vision/eye MP:0005391 9.17 IL2 IL2RA TNF ICAM1 CCR5 IFNG

Drugs & Therapeutics for Pulmonary Sarcoidosis

Drugs for Pulmonary Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 53-03-2 5865
4
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
6
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
7
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 942 89594
8
Acetylcholine Approved Phase 4 51-84-3 187
9 Adrenocorticotropic Hormone Phase 4
10 beta-endorphin Phase 4
11 Hormone Antagonists Phase 4,Phase 3,Not Applicable
12 Hormones Phase 4,Phase 3,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
14 Melanocyte-Stimulating Hormones Phase 4
15 Antiemetics Phase 4,Phase 3,Not Applicable
16 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
18 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
19 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
20 glucocorticoids Phase 4,Phase 3,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
22 Protective Agents Phase 4,Phase 2,Not Applicable
23 Antirheumatic Agents Phase 4,Phase 3,Phase 2
24 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
25 Immunosuppressive Agents Phase 4,Phase 2
26 Methylprednisolone acetate Phase 4,Not Applicable
27 Methylprednisolone Hemisuccinate Phase 4,Not Applicable
28 Neuroprotective Agents Phase 4,Not Applicable
29 Prednisolone acetate Phase 4,Not Applicable
30 Prednisolone hemisuccinate Phase 4,Not Applicable
31 Prednisolone phosphate Phase 4,Not Applicable
32 Analgesics Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4
35 Central Nervous System Stimulants Phase 4,Phase 1,Phase 2
36 Cholinergic Agents Phase 4,Phase 1,Phase 2
37 Nicotinic Agonists Phase 4,Phase 1,Phase 2
38
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
39
Hydroxychloroquine Approved Phase 3 118-42-3 3652
40
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
41
Mycophenolic acid Approved Phase 3 24280-93-1 446541
42
Methionine Approved, Nutraceutical Phase 2, Phase 3 63-68-3 6137
43 Carbon-11 methionine Phase 2, Phase 3
44 BB 1101 Phase 3
45 Dexamethasone acetate Phase 3 1177-87-3
46 HIV Protease Inhibitors Phase 3
47
protease inhibitors Phase 3
48 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
49 Antimalarials Phase 3
50 Antiparasitic Agents Phase 3

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Unknown status NCT02188017 Phase 4 Acthar gel
2 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Unknown status NCT01830959 Phase 4 Roflumilast;Placebo
3 Pilot Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in Subjects With Pulmonary Sarcoidosis Recruiting NCT03320070 Phase 4 repository corticotropin injection;Placebo
4 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
5 Pirfenidone for Progressive Fibrotic Sarcoidosis Recruiting NCT03260556 Phase 4 Pirfenidone;Placebos
6 Study of Nicotine Patches in Patients With Sarcoidosis Suspended NCT00701207 Phase 4 nicotine patch
7 Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Unknown status NCT02824419 Phase 2, Phase 3 Methionine;DOTANOC
8 Low-dose Dexamethasone in Newly Diagnosed Pulmonary Sarcoidosis Unknown status NCT01920919 Phase 3 Dexamethasone;Placebo
9 Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS). Completed NCT02200146 Phase 3 Prednisone;Hydroxychloroquine + Prednisone
10 Trial for the Diagnosis of Sarcoidosis Completed NCT00872612 Phase 3
11 Mycophenolate for Pulmonary Sarcoidosis Terminated NCT00262132 Phase 3 Mycophenolate
12 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed NCT00001877 Phase 2 Pentoxifylline
13 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2 Atorvastatin
14 Rituximab for Pulmonary Sarcoidosis Completed NCT00855205 Phase 2 Rituximab
15 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
16 Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis Recruiting NCT02888080 Phase 2 ACZ885;Placebo
17 Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis Recruiting NCT02024555 Phase 2 Levofloxacin;Ethambutol;Azithromycin;Rifampin;Placebo
18 Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study Recruiting NCT02265874 Phase 1, Phase 2 Habitrol;Placebo to Habitrol
19 A Phase 2, Safety, Tolerability, and Efficacy Study of PD 0360324 in Chronic Pulmonary Sarcoidosis Terminated NCT01732211 Phase 2
20 Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis Terminated NCT00926627 Phase 2 bosentan;placebo
21 Safety Study of Abatacept to Treat Refractory Sarcoidosis Terminated NCT00739960 Phase 2 Abatacept
22 Clinical Trial to Assess the Efficacy of Rituximab and Azathioprine in the Treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in Adult Patients With Common Variable Immunodeficiency (CVID) Withdrawn NCT02789397 Phase 2 Rituximab (RTX) and Azathioprine (AZA);Placebo Administration
23 Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis Completed NCT01169038 Phase 1 levaquin; ethambutol; rifampin and azithromycin.
24 Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis Terminated NCT01440192 Phase 1
25 Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study Unknown status NCT01384123
26 The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis Completed NCT01587001 Not Applicable Placebo
27 Antibody Response to Influenza Vaccine in Patients With Sarcoidosis Completed NCT00828828
28 Sarcoidosis-associated Pulmonary Hypertension Completed NCT01139710
29 The Occurence of Inflammation and Oxidative Stress in Lung Diseases Completed NCT00512967
30 Pathogen Specific Immunity in Patients With Sarcoidosis Completed NCT00217789
31 A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma Completed NCT01097954
32 Eye and Immunogenetic Features of Sarcoidosis Completed NCT00379275
33 The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis Recruiting NCT03336736
34 A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis Recruiting NCT03324503 Not Applicable Glucocorticoid (prednisone or prednisolone)
35 Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
36 SARCOLOWDOSE : Ultra-low Dose CT Scan and MRI in Thoracic Sarcoidosis Recruiting NCT03140644 Not Applicable
37 Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis Recruiting NCT03145922
38 Validation of the Analysis Methodology Behind the Use of Quantitative 18F-FDG PET/CT to Assess Lung Inflammation Not yet recruiting NCT03312712
39 Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease Not yet recruiting NCT03455686 Not Applicable
40 Stromal Gene Expression During Pulmonary Sarcoidosis Terminated NCT00837668
41 Pulmonary Rehabilitation in Patients With Sarcoidosis Terminated NCT02044939 Not Applicable

Search NIH Clinical Center for Pulmonary Sarcoidosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pulmonary Sarcoidosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pulmonary Sarcoidosis:
PDA001, Placenta-derived cells for pulmonary sarcoidosis
Embryonic/Adult Cultured Cells Related to Pulmonary Sarcoidosis:
Placenta-derived cells PMIDs: 22469567

Cochrane evidence based reviews: sarcoidosis, pulmonary

Genetic Tests for Pulmonary Sarcoidosis

Anatomical Context for Pulmonary Sarcoidosis

MalaCards organs/tissues related to Pulmonary Sarcoidosis:

41
Lung, T Cells, Lymph Node, Eye, Skin, Liver, Heart

Publications for Pulmonary Sarcoidosis

Articles related to Pulmonary Sarcoidosis:

(show top 50) (show all 675)
# Title Authors Year
1
Proangiogenic and Profibrotic Markers in Pulmonary Sarcoidosis. ( 29679363 )
2018
2
Pulmonary sarcoidosis. ( 29625772 )
2018
3
The Curious Omission of Treatment as a Predictor of Pulmonary Sarcoidosis Mortality. ( 29884262 )
2018
4
Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. ( 29610700 )
2018
5
A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. ( 29650028 )
2018
6
Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China. ( 29453299 )
2018
7
Pulmonary Sarcoidosis Induced by Anti-Tumor Necrosis Factor Therapy: A Paradoxical Effect. ( 29667945 )
2018
8
Right ventricular involvement and the extent of left ventricular enhancement with magnetic resonance predict adverse outcome in pulmonary sarcoidosis. ( 28967698 )
2018
9
Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis. ( 29857850 )
2018
10
Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. ( 29956871 )
2018
11
Atypical HRCT manifestations of pulmonary sarcoidosis. ( 29124658 )
2018
12
Th17-lineage cells in pulmonary sarcoidosis and LAPfgren's syndrome: Friend or foe? ( 29310925 )
2018
13
Daily home spirometry to detect early steroid treatment effects in newly treated pulmonary sarcoidosis. ( 29348185 )
2018
14
Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity. ( 29107084 )
2018
15
Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea. ( 29785303 )
2018
16
Pulmonary Sarcoidosis Presenting with Thin-walled Small Cysts. ( 28420852 )
2017
17
Repository corticotropin for Chronic Pulmonary Sarcoidosis. ( 28353116 )
2017
18
Pulmonary Sarcoidosis. ( 28750459 )
2017
19
[Analysis of an association of TNF -308G>A polymorphism with a risk for pulmonary sarcoidosis in the Russian population of the Republic of Karelia]. ( 28378732 )
2017
20
Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis. ( 27682024 )
2017
21
Pulmonary Sarcoidosis That Developed During the Treatment of a Patient With Crohn Disease by Using Infliximab. ( 28503520 )
2017
22
Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review. ( 28671172 )
2017
23
Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept. ( 28124746 )
2017
24
No evidence found for an association between prednisone dose and FVC change in newly-treated pulmonary sarcoidosis. ( 29137908 )
2017
25
Ulcerating Nodules within Tattoos Revealing Pulmonary Sarcoidosis. ( 28881429 )
2017
26
Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis. ( 29104468 )
2017
27
Pulmonary Sarcoidosis Activation following Neoadjuvant Pembrolizumab plus Chemotherapy Combination Therapy in a Patient with Non-Small Cell Lung Cancer: A Case Report. ( 29515398 )
2017
28
Living Kidney Donation From a Donor With Pulmonary Sarcoidosis: AA Case Report and Review of the Literature. ( 28583552 )
2017
29
Strategies for identifying pulmonary sarcoidosis patients at risk for severe or chronic disease. ( 28076979 )
2017
30
Pulmonary sarcoidosis mimicking tuberculosis: Importance of the galaxy sign on thoracic computed tomography. ( 28863878 )
2017
31
Pulmonary sarcoidosis: an update. ( 27766929 )
2017
32
Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ( 27826889 )
2017
33
Immunology repertoire study of pulmonary sarcoidosis T cells in CD4+, CD8+ PBMC and tissue. ( 29163767 )
2017
34
Resolution rate of pulmonary sarcoidosis and its related factors in a Japanese population. ( 28712145 )
2017
35
Predictors of Mortality in Pulmonary Sarcoidosis. ( 28728933 )
2017
36
The Pathogenesis of Pulmonary Sarcoidosis and Implications for Treatment. ( 29224832 )
2017
37
Clinical Features of Pulmonary Sarcoidosis Complicated by Lung Cancer. ( 28768963 )
2017
38
Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma. ( 28737580 )
2017
39
Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ( 28229082 )
2017
40
Local and Systemic CD4<sup>+</sup>T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. ( 29234685 )
2017
41
Title: Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis. ( 29237089 )
2017
42
Pulmonary Sarcoidosis in a patient with Multiple Sclerosis on daclizumab monotherapy. ( 29276998 )
2017
43
Dementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis. ( 28127435 )
2016
44
Treatment indications for pulmonary sarcoidosis. ( 27055843 )
2016
45
The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without LAPfgren's Syndrome. ( 28050119 )
2016
46
Altered miRNA expression in pulmonary sarcoidosis. ( 26768132 )
2016
47
Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis. ( 27688795 )
2016
48
Pulmonary sarcoidosis induced by the anti-PD1 monoclonal antibody pembrolizumab. ( 27091806 )
2016
49
Assessment of right ventricular systolic and diastolic parameters in pulmonary sarcoidosis. ( 26912008 )
2016
50
Clinical and radiological features of extra-pulmonary sarcoidosis: a pictorial essay. ( 27222055 )
2016

Variations for Pulmonary Sarcoidosis

Expression for Pulmonary Sarcoidosis

Search GEO for disease gene expression data for Pulmonary Sarcoidosis.

Pathways for Pulmonary Sarcoidosis

Pathways related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
2
Show member pathways
13.84 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
3
Show member pathways
13.6 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
4
Show member pathways
13.49 CCL2 CCL5 IFNG IL18 IL2 IL2RA
5
Show member pathways
13.34 CCL2 CCL5 CCR5 CXCL5 CXCR3 ICAM1
6
Show member pathways
13.32 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
7
Show member pathways
13.24 CCL2 CCL5 CCR5 CSF2 ICAM1 IFNG
8
Show member pathways
13.09 CCL2 CCL5 CCR5 CSF2 CXCL5 CXCR3
9
Show member pathways
13 ACE CCL2 CCL5 IFNG IL18 IL2
10
Show member pathways
12.9 ICAM1 IFNG IL18 IL2 IL2RA TNF
11
Show member pathways
12.86 CCL2 CCL5 CCR5 CXCL5 CXCR3
12
Show member pathways
12.69 CSF2 IFNG IL18 IL2 IL2RA TNF
13
Show member pathways
12.66 CCL2 CCL5 ICAM1 IFNG IL18 IL2
14
Show member pathways
12.62 CCL2 IFNG IL18 IL2 TNF
15 12.62 CCL2 CCL5 IFNG IL2 IL2RA TNF
16
Show member pathways
12.55 CSF2 ICAM1 IFNG IL2 TNF
17
Show member pathways
12.54 CCR5 CSF2 ICAM1 TNF
18
Show member pathways
12.49 IFNG IL18 IL2 IL2RA TNF
19
Show member pathways
12.47 CCR5 CSF2 IFNG IL2 TNF
20 12.46 CSF2 ICAM1 IL2 IL2RA TNF
21
Show member pathways
12.38 CCL2 CSF2 CXCL5 IFNG TNF
22
Show member pathways
12.37 CCL2 CCL5 ICAM1 IFNG IL2 TNF
23
Show member pathways
12.28 IFNG IL18 IL2 TNF
24 12.13 CCL2 ICAM1 IFNG TNF
25 12.09 CCL2 ICAM1 IFNG IL2 TNF
26
Show member pathways
12.07 CCL2 CCL5 CCR5 CXCL5 CXCR3
27
Show member pathways
12.07 CCL2 CCL5 ICAM1 IFNG IL18 IL2
28 12.06 CSF2 IFNG IL2 IL2RA TNF
29 12.03 CCL2 ICAM1 IL18 TNF
30
Show member pathways
12.03 CCR5 IFNG IL18 IL2 IL2RA
31
Show member pathways
12.02 IFNG IL2 IL2RA
32 11.94 CCR5 IFNG IL2 IL2RA
33 11.89 CCL2 ICAM1 TNF
34 11.88 CSF2 IL2RA TNF
35 11.87 CSF2 IFNG TNF
36 11.87 CSF2 ICAM1 IFNG IL2
37 11.82 CSF2 IFNG IL18
38 11.81 CSF2 IFNG IL2 TNF
39
Show member pathways
11.77 CSF2 IFNG IL2 IL2RA TNF
40 11.77 CCL2 CCL5 CSF2 CXCL5 ICAM1 TNF
41 11.74 CCL2 CCL5 CSF2 TNF
42
Show member pathways
11.72 IFNG IL2 IL2RA TNF
43
Show member pathways
11.65 CSF2 ICAM1 IFNG IL2 TNF
44 11.6 CCL2 IFNG IL18 TNF
45 11.59 IFNG IL2 TNF
46 11.56 IFNG IL2 TNF
47 11.54 CXCR3 IFNG IL18 IL2 IL2RA TNF
48 11.53 IFNG IL2 IL2RA
49 11.49 CCL2 ICAM1 IFNG IL18 TNF
50 11.44 ICAM1 IFNG IL18 TNF

GO Terms for Pulmonary Sarcoidosis

Cellular components related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ACE CCL2 CCL5 CSF2 CXCL5 IFNG
2 cell surface GO:0009986 9.65 CCR5 CXCR3 ICAM1 IL2RA TNF
3 external side of plasma membrane GO:0009897 9.43 ACE CCR5 CXCR3 ICAM1 IL2RA TNF
4 extracellular space GO:0005615 9.36 ACE CCL2 CCL5 CSF2 CXCL5 ICAM1

Biological processes related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.97 CCL5 CCR5 CXCL5 IL18 IL2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CCL5 ICAM1 TNF
3 cell surface receptor signaling pathway GO:0007166 9.93 CCL2 CCR5 CXCR3 IFNG IL2RA
4 regulation of signaling receptor activity GO:0010469 9.92 CCL2 CCL5 CSF2 CXCL5 IFNG IL18
5 defense response GO:0006952 9.89 CCR5 CXCL5 TNF
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 CCR5 CXCR3 IL2
7 chemotaxis GO:0006935 9.88 CCL2 CCL5 CCR5 CXCL5 CXCR3
8 cellular response to tumor necrosis factor GO:0071356 9.87 CCL2 CCL5 ICAM1
9 response to virus GO:0009615 9.86 CCL5 IFNG TNF
10 inflammatory response GO:0006954 9.86 CCL2 CCL5 CCR5 CXCL5 CXCR3 IL18
11 cellular response to interferon-gamma GO:0071346 9.85 CCL2 CCL5 ICAM1
12 cellular response to lipopolysaccharide GO:0071222 9.85 CCL2 CCR5 CSF2 ICAM1 TNF
13 cellular response to interleukin-1 GO:0071347 9.84 CCL2 CCL5 ICAM1
14 cell chemotaxis GO:0060326 9.83 CCL2 CCL5 CXCL5
15 regulation of insulin secretion GO:0050796 9.83 CCL5 IFNG TNF
16 positive regulation of T cell proliferation GO:0042102 9.82 CCL5 IL2 IL2RA
17 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 CCL5 IL18 TNF
18 humoral immune response GO:0006959 9.8 CCL2 IFNG TNF
19 chemokine-mediated signaling pathway GO:0070098 9.8 CCL2 CCL5 CCR5 CXCL5 CXCR3
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 CCL5 IL18 TNF
21 protein kinase B signaling GO:0043491 9.78 CCL2 CCL5 TNF
22 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL2 TNF
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG TNF
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 CCL5 CSF2 IFNG IL18 IL2
25 MAPK cascade GO:0000165 9.76 CCL2 CCL5 CCR5 CSF2 IL18 IL2
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 CCL5 IL18 TNF
27 positive regulation of activated T cell proliferation GO:0042104 9.72 IL18 IL2 IL2RA
28 natural killer cell activation GO:0030101 9.71 IL18 IL2
29 positive regulation of osteoclast differentiation GO:0045672 9.71 IFNG TNF
30 positive regulation of T cell differentiation GO:0045582 9.7 IL2 IL2RA
31 dendritic cell chemotaxis GO:0002407 9.7 CCL5 CCR5
32 regulation of regulatory T cell differentiation GO:0045589 9.7 IFNG IL2 IL2RA
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG TNF
34 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 CSF2 IL18
35 positive regulation of interleukin-17 production GO:0032740 9.68 IL18 IL2
36 positive regulation of podosome assembly GO:0071803 9.68 CSF2 TNF
37 neutrophil activation GO:0042119 9.67 CCL5 IL18
38 interleukin-2-mediated signaling pathway GO:0038110 9.67 IL2 IL2RA
39 neutrophil mediated immunity GO:0002446 9.67 ACE CXCL5
40 macrophage chemotaxis GO:0048246 9.67 CCL2 CCL5 SFTPD
41 negative regulation of lymphocyte proliferation GO:0050672 9.64 IL2 IL2RA
42 positive regulation of tissue remodeling GO:0034105 9.64 IL18 IL2
43 negative regulation of macrophage apoptotic process GO:2000110 9.63 CCL5 CCR5
44 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
45 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IFNG
46 cytokine-mediated signaling pathway GO:0019221 9.61 CCL2 CCL5 CCR5 CSF2 ICAM1 IL18
47 regulation of T cell homeostatic proliferation GO:0046013 9.58 IL2 IL2RA
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 IFNG TNF
50 immune response GO:0006955 9.32 CCL2 CCL5 CCR5 CSF2 CXCL5 IFNG

Molecular functions related to Pulmonary Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 CSF2 IL2 IL2RA
2 chemokine receptor activity GO:0004950 9.26 CCR5 CXCR3
3 cytokine activity GO:0005125 9.23 CCL2 CCL5 CSF2 CXCL5 IFNG IL18
4 chemokine activity GO:0008009 9.13 CCL2 CCL5 CXCL5

Sources for Pulmonary Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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