MCID: PLM018
MIFTS: 38

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 44 15 73
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 44 D047868
NCIt 50 C5656
UMLS 73 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to hemangioma and papillary adenoma, and has symptoms including hemoptysis, chest pain and coughing. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Adherens junction and Arf6 trafficking events. The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and lymph node.

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 hemangioma 31.0 CHGA NKX2-1 SFTPB SYP
2 papillary adenoma 30.0 KRT7 NKX2-1
3 sclerosing hemangioma 29.9 CHGA CTNNB1 CTNND1 KRT7 NKX2-1 SFTPB
4 papillary adenocarcinoma 29.9 KRT7 NKX2-1
5 thyroid cancer 29.7 CHGA CTNNB1 NKX2-1
6 prostate small cell carcinoma 10.2 NKX2-1 SYP
7 tubular adenocarcinoma 10.2 CHGA SYP
8 extraskeletal ewing sarcoma 10.2 NKX2-1 SYP
9 ureter small cell carcinoma 10.2 CHGA SYP
10 esophageal neuroendocrine tumor 10.2 CHGA SYP
11 urinary bladder small cell neuroendocrine carcinoma 10.2 CHGA SYP
12 ovarian large-cell neuroendocrine carcinoma 10.2 CHGA SYP
13 auditory system cancer 10.2 CHGA SYP
14 adenoma of the pancreas 10.2 CHGA SYP
15 acinar cell cystadenocarcinoma 10.2 CHGA SYP
16 adenocarcinoma 10.2
17 peritoneal serous adenocarcinoma 10.2 CHGA SYP
18 cellular ependymoma 10.2 CHGA SYP
19 gallbladder small cell carcinoma 10.2 CHGA SYP
20 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
21 gastrointestinal neuroendocrine tumor 10.2 CHGA SYP
22 subependymal giant cell astrocytoma 10.2 NKX2-1 SYP
23 pulmonary large cell neuroendocrine carcinoma 10.2 CHGA SYP
24 atypical follicular adenoma 10.2 CHGA SYP
25 chordoid meningioma 10.2 CHGA SYP
26 olfactory groove meningioma 10.2 CHGA SYP
27 cauda equina neoplasm 10.2 CHGA SYP
28 conventional angiosarcoma 10.2 CHGA SYP
29 olfactory nerve neoplasm 10.2 CHGA SYP
30 autonomic nervous system benign neoplasm 10.2 CHGA SYP
31 nodular ganglioneuroblastoma 10.2 CHGA SYP
32 hemangioma of lung 10.1 NKX2-1 SFTPB
33 respiratory distress syndrome in premature infants 10.1 NKX2-1 SFTPB
34 pineocytoma 10.1 CHGA SYP
35 gastric small cell carcinoma 10.1 CHGA SYP
36 pancreatoblastoma 10.1 CHGA SYP
37 subependymoma 10.1 CHGA SYP
38 anterior cranial fossa meningioma 10.1 CHGA SYP
39 pleomorphic xanthoastrocytoma 10.1 CHGA SYP
40 tanycytic ependymoma 10.1 CHGA SYP
41 papillary ependymoma 10.1 CHGA SYP
42 non-functioning pancreatic endocrine tumor 10.1 CHGA SYP
43 central neurocytoma 10.1 CHGA SYP
44 binswanger's disease 10.1 CHGA SYP
45 carcinoid syndrome 10.1 CHGA SYP
46 cervix small cell carcinoma 10.1 CHGA SYP
47 cerebellar liponeurocytoma 10.1 CHGA SYP
48 cranial nerve malignant neoplasm 10.1 CHGA SYP
49 malignant pheochromocytoma 10.1 CHGA SYP
50 olfactory neuroblastoma 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


hemoptysis, chest pain, coughing

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3 Androgens Phase 1
4 Antimetabolites, Antineoplastic Phase 1
5 Immunosuppressive Agents Phase 1
6 Immunologic Factors Phase 1
7 Histone Deacetylase Inhibitors Phase 1
8 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

41
Lung, Thyroid, Lymph Node, Kidney, Ovary, Pancreas, Thymus

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 95)
# Title Authors Year
1
<sup>18</sup>F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. ( 29930720 )
2018
2
Coexistence of glandular papilloma and sclerosing pneumocytoma in the bronchiole. ( 29696743 )
2018
3
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. ( 29644341 )
2018
4
Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases. ( 28881050 )
2018
5
Genome profile in a extremely rare case of pulmonary sclerosing pneumocytoma presenting with diffusely-scattered nodules in the right lung. ( 29236566 )
2018
6
A case of microscopic, multiple sclerosing pneumocytoma. ( 29451344 )
2018
7
Sclerosing pneumocytoma diagnosed by preoperative endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). ( 29524065 )
2018
8
Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes. ( 30004067 )
2018
9
WITHDRAWN:A Clinicopathologic Study of 220 Cases of Pulmonary Sclerosing Pneumocytoma in Korea: A Nationwide Survey. ( 30008196 )
2018
10
Pulmonary Sclerosing Pneumocytoma. ( 30247298 )
2018
11
Tail sign: Pulmonary sclerosing pneumocytoma. ( 30309107 )
2018
12
A case of pulmonary sclerosing pneumocytoma in the hilar lesion. ( 30488193 )
2018
13
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. ( 28357098 )
2017
14
Incidental Sclerosing Pneumocytoma Detected on Bone Scintigraphy. ( 27749415 )
2017
15
Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma. ( 27902879 )
2017
16
An 111In-Pentetreotide Positive Sclerosing Pneumocytoma. ( 28166143 )
2017
17
Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review. ( 28249927 )
2017
18
Sclerosing Pneumocytoma of the Lung: A Case Report. ( 28384875 )
2017
19
Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes. ( 28474862 )
2017
20
Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis. ( 28825313 )
2017
21
Pulmonary Sclerosing Pneumocytoma: Did Lightening Just Strike Twice? ( 29191617 )
2017
22
Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer. ( 29221270 )
2017
23
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
24
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. ( 27812454 )
2016
25
Pitfalls and Key Features of a Case of Sclerosing Pneumocytoma: A Cytological Challenge? ( 26934286 )
2016
26
A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma. ( 27160435 )
2016
27
Pulmonary sclerosing pneumocytoma (sclerosing haemangioma): Radical radiation therapy. ( 27302690 )
2016
28
Sclerosing Pneumocytoma with Lymph Node Metastasis. ( 27346414 )
2016
29
Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature. ( 27385997 )
2016
30
Bone metastasis in pulmonary sclerosing hemangioma. ( 26552471 )
2015
31
Pulmonary sclerosing pneumocytoma of the lung: CT characteristics in a large series of a tertiary referral center. ( 25634202 )
2015
32
Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review. ( 26175598 )
2015
33
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. ( 24944657 )
2014
34
Case of pulmonary pneumocytoma: a probable cytological diagnosis with histopathological confirmation. ( 24739840 )
2014
35
Multiple pulmonary sclerosing hemangiomas (pneumocytoma) mimicking lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. ( 25210285 )
2014
36
Clustered pulmonary sclerosing pneumocytoma in a young man: a case report. ( 24667045 )
2014
37
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). ( 23587094 )
2013
38
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. ( 24887810 )
2013
39
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). ( 23290153 )
2013
40
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. ( 23910931 )
2013
41
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. ( 22291338 )
2013
42
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. ( 23838116 )
2013
43
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. ( 23227905 )
2012
44
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. ( 22740968 )
2012
45
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. ( 22614067 )
2012
46
Pulmonary sclerosing hemangioma: report of two cases. ( 22943472 )
2012
47
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. ( 21264765 )
2011
48
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. ( 20422318 )
2011
49
Coexistence of pulmonary sclerosing hemangioma and primary adenocarcinoma in the same nodule of lung. ( 21599956 )
2011
50
Pulmonary sclerosing hemangioma: pitfalls in management. ( 21471259 )
2011

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Cellular components related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.26 CTNNB1 CTNND1
2 postsynaptic density, intracellular component GO:0099092 9.16 CTNNB1 CTNND1
3 presynaptic active zone cytoplasmic component GO:0098831 8.96 CTNNB1 CTNND1
4 Schaffer collateral - CA1 synapse GO:0098685 8.8 CTNNB1 CTNND1 SYP

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.32 CTNNB1 NKX2-1
2 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
3 adherens junction organization GO:0034332 9.16 CTNNB1 CTNND1
4 epithelial tube branching involved in lung morphogenesis GO:0060441 8.96 CTNNB1 NKX2-1
5 entry of bacterium into host cell GO:0035635 8.62 CTNNB1 CTNND1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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