MCID: PLM018
MIFTS: 36

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 44 15 73
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 44 D047868
NCIt 50 C5656
SNOMED-CT 68 707365008
UMLS 73 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to papillary adenocarcinoma and sclerosing hemangioma, and has symptoms including chest pain, coughing and hemoptysis. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Adherens junction and Arf6 trafficking events. The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and thyroid.

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 papillary adenocarcinoma 29.6 KRT7 NKX2-1
2 sclerosing hemangioma 26.8 CHGA CTNNB1 CTNND1 KRT7 NKX2-1 SFTPB
3 hemangioma 10.7
4 embryoma 10.6 NKX2-1 SYP
5 malignant teratoma 10.6 NKX2-1 SYP
6 extraskeletal ewing sarcoma 10.5 NKX2-1 SYP
7 esophageal neuroendocrine tumor 10.5 CHGA SYP
8 ureter small cell carcinoma 10.5 CHGA SYP
9 urinary bladder small cell neuroendocrine carcinoma 10.5 CHGA SYP
10 auditory system cancer 10.5 CHGA SYP
11 adenoma of the pancreas 10.5 CHGA SYP
12 acinar cell cystadenocarcinoma 10.5 CHGA SYP
13 peritoneal serous adenocarcinoma 10.5 CHGA SYP
14 cellular ependymoma 10.5 CHGA SYP
15 gallbladder small cell carcinoma 10.5 CHGA SYP
16 primary hepatic neuroendocrine carcinoma 10.5 CHGA SYP
17 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
18 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA SYP
19 atypical follicular adenoma 10.5 CHGA SYP
20 chordoid meningioma 10.5 CHGA SYP
21 olfactory nerve neoplasm 10.5 CHGA SYP
22 cauda equina neoplasm 10.5 CHGA SYP
23 conventional angiosarcoma 10.5 CHGA SYP
24 nodular ganglioneuroblastoma 10.5 CHGA SYP
25 hemangioma of lung 10.5 NKX2-1 SFTPB
26 pineocytoma 10.5 CHGA SYP
27 gastric squamous cell carcinoma 10.5 CHGA SYP
28 gastric small cell carcinoma 10.5 CHGA SYP
29 pancreatoblastoma 10.5 CHGA SYP
30 subependymoma 10.5 CHGA SYP
31 ureter, cancer of 10.5 CHGA SYP
32 tanycytic ependymoma 10.5 CHGA SYP
33 papillary ependymoma 10.5 CHGA SYP
34 non-functioning pancreatic endocrine tumor 10.5 CHGA SYP
35 pleomorphic xanthoastrocytoma 10.4 CHGA SYP
36 central neurocytoma 10.4 CHGA SYP
37 newborn respiratory distress syndrome 10.4 NKX2-1 SFTPB
38 pancreatic cystadenocarcinoma 10.4 CHGA SYP
39 binswanger's disease 10.4 CHGA SYP
40 carcinoid syndrome 10.4 CHGA SYP
41 cranial nerve malignant neoplasm 10.4 CHGA SYP
42 cervix small cell carcinoma 10.4 CHGA SYP
43 olfactory neuroblastoma 10.4 CHGA SYP
44 cerebellar liponeurocytoma 10.4 CHGA SYP
45 mixed ductal-endocrine carcinoma 10.4 CHGA SYP
46 breast papillary carcinoma 10.4 CHGA SYP
47 ganglioneuroma 10.3 CHGA SYP
48 ganglioglioma 10.3 CHGA SYP
49 goblet cell carcinoid 10.3 CHGA CTNNB1
50 central nervous system organ benign neoplasm 10.3 CTNNB1 SYP

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


chest pain, coughing, hemoptysis

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3 Histone Deacetylase Inhibitors Phase 1
4 Androgens Phase 1
5 Immunosuppressive Agents Phase 1
6 Antimetabolites Phase 1
7 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

41
Lung, Lymph Node, Thyroid, Fetal Lung, Kidney, Bone

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 63)
# Title Authors Year
1
<sup>18</sup>F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. ( 29930720 )
2018
2
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. ( 28357098 )
2017
3
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
4
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. ( 27812454 )
2016
5
Bone metastasis in pulmonary sclerosing hemangioma. ( 26552471 )
2015
6
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. ( 24944657 )
2014
7
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). ( 23587094 )
2013
8
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. ( 24887810 )
2013
9
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). ( 23290153 )
2013
10
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. ( 23910931 )
2013
11
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. ( 22291338 )
2013
12
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. ( 23838116 )
2013
13
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. ( 23227905 )
2012
14
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. ( 22740968 )
2012
15
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. ( 22614067 )
2012
16
Pulmonary sclerosing hemangioma: report of two cases. ( 22943472 )
2012
17
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. ( 21264765 )
2011
18
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. ( 20422318 )
2011
19
Coexistence of pulmonary sclerosing hemangioma and primary adenocarcinoma in the same nodule of lung. ( 21599956 )
2011
20
Pulmonary sclerosing hemangioma: pitfalls in management. ( 21471259 )
2011
21
Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. ( 21649526 )
2011
22
A case of pulmonary sclerosing hemangioma surrounded by giant cystic change on high-resolution computed tomography. ( 20634757 )
2011
23
F-18 FDG PET/CT in evaluation of pulmonary sclerosing hemangioma. ( 21467848 )
2011
24
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection. ( 22263122 )
2011
25
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. ( 21645337 )
2011
26
Large masses with diffuse calcification: pulmonary sclerosing hemangioma. ( 20732478 )
2010
27
Cytogenetic study of a pulmonary sclerosing hemangioma. ( 19837274 )
2009
28
Recurrence of pulmonary sclerosing hemangioma. ( 18278694 )
2008
29
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. ( 17473941 )
2007
30
Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma. ( 17873892 )
2007
31
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. ( 17914564 )
2007
32
[Pulmonary sclerosing hemangioma in a patient with Cowden syndrome]. ( 17663895 )
2007
33
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. ( 17383052 )
2007
34
Pulmonary sclerosing hemangioma manifesting as a nodule with irregular air clefts on high-resolution CT. ( 17579131 )
2007
35
Pulmonary sclerosing hemangioma with pulmonary metastasis. ( 16902885 )
2006
36
Pulmonary sclerosing hemangioma presenting as solitary pulmonary nodule: dynamic CT findings and histopathologic comparisons. ( 16861548 )
2006
37
Proteomic analysis of pulmonary sclerosing hemangioma. ( 16892484 )
2006
38
[Study of androgen receptor and phosphoglycerate kinase gene polymorphism in major cellular components of the so-called pulmonary sclerosing hemangioma]. ( 16776996 )
2006
39
Bilateral multiple pulmonary sclerosing hemangioma. ( 15828298 )
2005
40
Expression patterns of markers for type II pneumocytes in pulmonary sclerosing hemangiomas and fetal lung tissues. ( 15974816 )
2005
41
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. ( 16305908 )
2005
42
Expression of the estrogen receptor beta in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non-small cell lung carcinomas. ( 16226111 )
2005
43
Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. ( 15188145 )
2004
44
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. ( 15138814 )
2004
45
Clinicopathological analysis of pulmonary sclerosing hemangioma. ( 15561002 )
2004
46
Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. ( 15116333 )
2004
47
[Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]. ( 14720435 )
2003
48
Pulmonary sclerosing hemangioma with lymph node metastases. ( 14571291 )
2003
49
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. ( 12653576 )
2003
50
[The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. ( 11955335 )
2002

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.32 CTNNB1 NKX2-1
2 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
3 adherens junction organization GO:0034332 9.16 CTNNB1 CTNND1
4 epithelial tube branching involved in lung morphogenesis GO:0060441 8.96 CTNNB1 NKX2-1
5 entry of bacterium into host cell GO:0035635 8.62 CTNNB1 CTNND1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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