MCID: PLM018
MIFTS: 38

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 45 15 74
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 45 D047868
NCIt 51 C5656
UMLS 74 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to hemangioma and carcinoid syndrome, and has symptoms including hemoptysis, chest pain and coughing. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Adherens junction and Arf6 trafficking events. The drugs Parathyroid hormone and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and thyroid.

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.8 CHGA NKX2-1 SFTPB SYP
2 carcinoid syndrome 30.2 CHGA SYP
3 papillary adenoma 30.0 KRT7 NKX2-1
4 papillary adenocarcinoma 29.9 KRT7 NKX2-1
5 thyroid cancer 29.6 CHGA CTNNB1 NKX2-1
6 sclerosing hemangioma 29.1 CHGA CTNNB1 CTNND1 KRT7 NKX2-1 SFTPB
7 extraskeletal ewing sarcoma 10.3 NKX2-1 SYP
8 tubular adenocarcinoma 10.3 CHGA SYP
9 ureter small cell carcinoma 10.3 CHGA SYP
10 esophageal neuroendocrine tumor 10.3 CHGA SYP
11 urinary bladder small cell neuroendocrine carcinoma 10.3 CHGA SYP
12 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA SYP
13 auditory system cancer 10.3 CHGA SYP
14 acinar cell cystadenocarcinoma 10.2 CHGA SYP
15 peritoneal serous adenocarcinoma 10.2 CHGA SYP
16 cellular ependymoma 10.2 CHGA SYP
17 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
18 subependymal giant cell astrocytoma 10.2 NKX2-1 SYP
19 gastrointestinal neuroendocrine tumor 10.2 CHGA SYP
20 pulmonary large cell neuroendocrine carcinoma 10.2 CHGA SYP
21 atypical follicular adenoma 10.2 CHGA SYP
22 chordoid meningioma 10.2 CHGA SYP
23 olfactory groove meningioma 10.2 CHGA SYP
24 cauda equina neoplasm 10.2 CHGA SYP
25 conventional angiosarcoma 10.2 CHGA SYP
26 olfactory nerve neoplasm 10.2 CHGA SYP
27 autonomic nervous system benign neoplasm 10.2 CHGA SYP
28 nodular ganglioneuroblastoma 10.2 CHGA SYP
29 hemangioma of lung 10.2 NKX2-1 SFTPB
30 respiratory distress syndrome in premature infants 10.2 NKX2-1 SFTPB
31 pineocytoma 10.2 CHGA SYP
32 gastric small cell carcinoma 10.2 CHGA SYP
33 pancreatoblastoma 10.2 CHGA SYP
34 subependymoma 10.2 CHGA SYP
35 anterior cranial fossa meningioma 10.2 CHGA SYP
36 pleomorphic xanthoastrocytoma 10.2 CHGA SYP
37 tanycytic ependymoma 10.2 CHGA SYP
38 papillary ependymoma 10.2 CHGA SYP
39 non-functioning pancreatic endocrine tumor 10.2 CHGA SYP
40 central neurocytoma 10.2 CHGA SYP
41 binswanger's disease 10.2 CHGA SYP
42 cervix small cell carcinoma 10.2 CHGA SYP
43 cerebellar liponeurocytoma 10.2 CHGA SYP
44 cranial nerve malignant neoplasm 10.2 CHGA SYP
45 malignant pheochromocytoma 10.2 CHGA SYP
46 olfactory neuroblastoma 10.2 CHGA SYP
47 mixed ductal-endocrine carcinoma 10.2 CHGA SYP
48 adenocarcinoma 10.2
49 ganglioneuroma 10.2 CHGA SYP
50 endocrine organ benign neoplasm 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


hemoptysis, chest pain, coughing

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Fluorouracil Approved Phase 1 51-21-8 3385
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Androgens Phase 1
5 Antimetabolites Phase 1
6 Immunosuppressive Agents Phase 1
7 Antimetabolites, Antineoplastic Phase 1
8 Immunologic Factors Phase 1
9 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

42
Lung, Lymph Node, Thyroid, Bone, Kidney, Breast

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 98)
# Title Authors Year
1
Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital. ( 30691016 )
2019
2
Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature. ( 30702609 )
2019
3
Pulmonary sclerosing pneumocytoma, a rare tumor of the lung. ( 30847275 )
2019
4
Pulmonary sclerosing pneumocytoma presenting as slow-growing multiple nodules over a long period. ( 30891111 )
2019
5
<sup>18</sup>F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. ( 29930720 )
2018
6
Coexistence of glandular papilloma and sclerosing pneumocytoma in the bronchiole. ( 29696743 )
2018
7
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. ( 29644341 )
2018
8
Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases. ( 28881050 )
2018
9
Genome profile in a extremely rare case of pulmonary sclerosing pneumocytoma presenting with diffusely-scattered nodules in the right lung. ( 29236566 )
2018
10
A case of microscopic, multiple sclerosing pneumocytoma. ( 29451344 )
2018
11
Sclerosing pneumocytoma diagnosed by preoperative endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). ( 29524065 )
2018
12
Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes. ( 30004067 )
2018
13
WITHDRAWN:A Clinicopathologic Study of 220 Cases of Pulmonary Sclerosing Pneumocytoma in Korea: A Nationwide Survey. ( 30008196 )
2018
14
Pulmonary Sclerosing Pneumocytoma. ( 30247298 )
2018
15
Tail sign: Pulmonary sclerosing pneumocytoma. ( 30309107 )
2018
16
A case of pulmonary sclerosing pneumocytoma in the hilar lesion. ( 30488193 )
2018
17
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. ( 28357098 )
2017
18
Incidental Sclerosing Pneumocytoma Detected on Bone Scintigraphy. ( 27749415 )
2017
19
Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma. ( 27902879 )
2017
20
An 111In-Pentetreotide Positive Sclerosing Pneumocytoma. ( 28166143 )
2017
21
Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review. ( 28249927 )
2017
22
Sclerosing Pneumocytoma of the Lung: A Case Report. ( 28384875 )
2017
23
Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes. ( 28474862 )
2017
24
Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis. ( 28825313 )
2017
25
Pulmonary Sclerosing Pneumocytoma: Did Lightening Just Strike Twice? ( 29191617 )
2017
26
Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer. ( 29221270 )
2017
27
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
28
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. ( 27812454 )
2016
29
Pitfalls and Key Features of a Case of Sclerosing Pneumocytoma: A Cytological Challenge? ( 26934286 )
2016
30
A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma. ( 27160435 )
2016
31
Pulmonary sclerosing pneumocytoma (sclerosing haemangioma): Radical radiation therapy. ( 27302690 )
2016
32
Sclerosing Pneumocytoma with Lymph Node Metastasis. ( 27346414 )
2016
33
Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature. ( 27385997 )
2016
34
Bone metastasis in pulmonary sclerosing hemangioma. ( 26552471 )
2015
35
Pulmonary sclerosing pneumocytoma of the lung: CT characteristics in a large series of a tertiary referral center. ( 25634202 )
2015
36
Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review. ( 26175598 )
2015
37
Pulmonary sclerosing hemangioma with lymph node metastasis: A case report and literature review. ( 24944657 )
2014
38
Clustered pulmonary sclerosing pneumocytoma in a young man: a case report. ( 24667045 )
2014
39
Case of pulmonary pneumocytoma: a probable cytological diagnosis with histopathological confirmation. ( 24739840 )
2014
40
Multiple pulmonary sclerosing hemangiomas (pneumocytoma) mimicking lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. ( 25210285 )
2014
41
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). ( 23587094 )
2013
42
Unusual coexistence of pulmonary sclerosing hemangioma and pericardial cyst. ( 24887810 )
2013
43
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). ( 23290153 )
2013
44
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. ( 23910931 )
2013
45
18F-FDG PET/CT features of pulmonary sclerosing hemangioma. ( 22291338 )
2013
46
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. ( 23838116 )
2013
47
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. ( 23227905 )
2012
48
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. ( 22740968 )
2012
49
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. ( 22614067 )
2012
50
Pulmonary sclerosing hemangioma: report of two cases. ( 22943472 )
2012

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Cellular components related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.26 CTNNB1 CTNND1
2 postsynaptic density, intracellular component GO:0099092 9.16 CTNNB1 CTNND1
3 presynaptic active zone cytoplasmic component GO:0098831 8.96 CTNNB1 CTNND1
4 Schaffer collateral - CA1 synapse GO:0098685 8.8 CTNNB1 CTNND1 SYP

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.32 CTNNB1 NKX2-1
2 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
3 adherens junction organization GO:0034332 9.16 CTNNB1 CTNND1
4 epithelial tube branching involved in lung morphogenesis GO:0060441 8.96 CTNNB1 NKX2-1
5 entry of bacterium into host cell GO:0035635 8.62 CTNNB1 CTNND1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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