MCID: PLM018
MIFTS: 35

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 44 15 72
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 44 D047868
NCIt 50 C5656
UMLS 72 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to hemangioma and carcinoid syndrome, and has symptoms including chest pain, hemoptysis and coughing. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Adherens junction and Arf6 trafficking events. The drugs Parathyroid hormone and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and thyroid.

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.8 SYP SFTPB NKX2-1 CHGA
2 carcinoid syndrome 30.5 SYP CHGA
3 papillary adenoma 30.1 NKX2-1 KRT7
4 pulmonary blastoma 30.0 SYP NKX2-1 CHGA
5 papillary adenocarcinoma 29.9 NKX2-1 KRT7
6 teratoma 29.6 SYP NKX2-1 KRT7
7 carcinosarcoma 29.4 KRT7 CTNNB1
8 sarcoma, synovial 29.1 KRT7 CTNNB1
9 small cell carcinoma 29.1 SYP NKX2-1 KRT7 CHGA
10 lung cancer susceptibility 3 28.6 SFTPB NKX2-1 KRT7 CTNNB1
11 lung benign neoplasm 28.2 SYP SFTPB NKX2-1 KRT7 CHGA
12 sclerosing hemangioma 28.0 SYP SFTPB NKX2-1 KRT7 CTNND1 CTNNB1
13 extraskeletal ewing sarcoma 10.4 SYP NKX2-1
14 tubular adenocarcinoma 10.4 SYP CHGA
15 ureter small cell carcinoma 10.4 SYP CHGA
16 esophageal neuroendocrine tumor 10.4 SYP CHGA
17 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP CHGA
18 ovarian large-cell neuroendocrine carcinoma 10.4 SYP CHGA
19 auditory system cancer 10.4 SYP CHGA
20 acinar cell cystadenocarcinoma 10.4 SYP CHGA
21 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
22 cellular ependymoma 10.4 SYP CHGA
23 peritoneal serous adenocarcinoma 10.4 SYP CHGA
24 gastrointestinal neuroendocrine tumor 10.4 SYP CHGA
25 subependymal giant cell astrocytoma 10.4 SYP NKX2-1
26 chordoid meningioma 10.4 SYP CHGA
27 atypical follicular adenoma 10.4 SYP CHGA
28 pulmonary large cell neuroendocrine carcinoma 10.4 SYP CHGA
29 olfactory groove meningioma 10.4 SYP CHGA
30 cauda equina neoplasm 10.4 SYP CHGA
31 conventional angiosarcoma 10.4 SYP CHGA
32 olfactory nerve neoplasm 10.4 SYP CHGA
33 nodular ganglioneuroblastoma 10.4 SYP CHGA
34 autonomic nervous system benign neoplasm 10.4 SYP CHGA
35 hemangioma of lung 10.4 SFTPB NKX2-1
36 pineocytoma 10.4 SYP CHGA
37 pulmonary coin lesion 10.4
38 subependymoma 10.4 SYP CHGA
39 pancreatoblastoma 10.4 SYP CHGA
40 gastric small cell carcinoma 10.4 SYP CHGA
41 respiratory distress syndrome in premature infants 10.4 SFTPB NKX2-1
42 anterior cranial fossa meningioma 10.4 SYP CHGA
43 non-functioning pancreatic endocrine tumor 10.3 SYP CHGA
44 papillary ependymoma 10.3 SYP CHGA
45 tanycytic ependymoma 10.3 SYP CHGA
46 pleomorphic xanthoastrocytoma 10.3 SYP CHGA
47 binswanger's disease 10.3 SYP CHGA
48 central neurocytoma 10.3 SYP CHGA
49 cervix small cell carcinoma 10.3 SYP CHGA
50 cerebellar liponeurocytoma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


chest pain, hemoptysis, coughing

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Fluorouracil Approved Phase 1 51-21-8 3385
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Androgens Phase 1
5 Immunologic Factors Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Immunosuppressive Agents Phase 1
8 Antimetabolites Phase 1
9 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

41
Lung, Lymph Node, Thyroid, Bone, Kidney, Breast, Endothelial

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 175)
# Title Authors PMID Year
1
18 F-FDG PET/CT imaging: A supplementary understanding of pulmonary sclerosing pneumocytoma. 38
31131992 2019
2
Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report. 38
31428771 2019
3
Sclerosing Pneumocytoma of the Lungs Arising in a Child With PTEN Mutation. 38
31166879 2019
4
Post-tuberculosis Pneumocytoma. 38
31133161 2019
5
Symptomatic pulmonary sclerosing hemangioma: a rare case of a solitary pulmonary nodule in a woman of advanced age. 38
30971157 2019
6
Pulmonary sclerosing pneumocytoma presenting as slow-growing multiple nodules over a long period. 38
30891111 2019
7
Pulmonary sclerosing pneumocytoma presenting a peritumoral halo and an intervening lucent zone on computed tomography: Radiology-pathology correlation. 38
30964602 2019
8
Sclerosing pneumocytoma: Case report of a rare endobronchial presentation. 38
30985653 2019
9
Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature. 38
30702609 2019
10
Multifocal pulmonary mucinous cystic neoplasm with ovarian-like stroma: Once in a blue moon-case report. 38
30828544 2019
11
Pulmonary sclerosing pneumocytoma demonstrating intratumoral hematoma. 38
31194169 2019
12
Pulmonary sclerosing pneumocytoma, a rare tumor of the lung. 38
30847275 2019
13
Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital. 38
30691016 2019
14
A case of pulmonary sclerosing pneumocytoma in the hilar lesion. 38
30488193 2018
15
Pulmonary Sclerosing Pneumocytoma. 38
30247298 2018
16
Tail sign: Pulmonary sclerosing pneumocytoma. 38
30309107 2018
17
18F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. 38
29930720 2018
18
Coexistence of glandular papilloma and sclerosing pneumocytoma in the bronchiole. 38
29696743 2018
19
WITHDRAWN:A Clinicopathologic Study of 220 Cases of Pulmonary Sclerosing Pneumocytoma in Korea: A Nationwide Survey. 38
30008196 2018
20
Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes. 38
30004067 2018
21
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. 38
29644341 2018
22
Sclerosing pneumocytoma diagnosed by preoperative endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). 38
29524065 2018
23
A case of microscopic, multiple sclerosing pneumocytoma. 38
29451344 2018
24
Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases. 38
28881050 2018
25
[Surgical Treatment of Pseudotumours of the Lung]. 38
28641331 2018
26
[On the histo- and morphogenesis of sclerosing pneumocytoma and its diagnostic criteria]. 38
29460895 2018
27
Genome profile in a extremely rare case of pulmonary sclerosing pneumocytoma presenting with diffusely-scattered nodules in the right lung. 38
29236566 2018
28
Pulmonary Sclerosing Pneumocytoma: Did Lightening Just Strike Twice? 38
29191617 2017
29
Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis. 38
28825313 2017
30
Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer. 38
29221270 2017
31
Pneumocytoma (sclerosing hemangioma), a potential pitfall. 38
28398699 2017
32
Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes. 38
28474862 2017
33
An 111In-Pentetreotide Positive Sclerosing Pneumocytoma. 38
28166143 2017
34
Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma. 38
27902879 2017
35
Sclerosing Pneumocytoma of the Lung: A Case Report. 38
28384875 2017
36
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. 38
28357098 2017
37
Incidental Sclerosing Pneumocytoma Detected on Bone Scintigraphy. 38
27749415 2017
38
Single-incision video-assisted thoracoscopic surgery left-lower lobe anterior segmentectomy (S8). 38
29078674 2017
39
Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review. 38
28249927 2017
40
[Multiple Pulmonary Sclerosing Pneumocytoma with Abnormal Accumulation of Fluorodeoxyglucose-positron Emission Tomography Diagnosed by Surgical Treatment;Report of a Case]. 38
27909285 2016
41
Pulmonary sclerosing pneumocytoma (sclerosing haemangioma): Radical radiation therapy. 38
27302690 2016
42
Sclerosing Pneumocytoma with Lymph Node Metastasis. 38
27346414 2016
43
A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma. 38
27160435 2016
44
Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. 38
27601661 2016
45
Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature. 38
27385997 2016
46
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. 38
27231179 2016
47
Pulmonary Hilar Tumor: An Unusual Presentation of Sclerosing Hemangioma. 38
27761142 2016
48
Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male. 38
27812454 2016
49
Pitfalls and Key Features of a Case of Sclerosing Pneumocytoma: A Cytological Challenge? 38
26934286 2016
50
The role of video-assisted thoracoscopic surgery in management of the multiple ground-glass nodules. 38
26728679 2015

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

GO Terms for Pulmonary Sclerosing Hemangioma

Cellular components related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.26 CTNND1 CTNNB1
2 presynaptic active zone cytoplasmic component GO:0098831 9.16 CTNND1 CTNNB1
3 postsynaptic density, intracellular component GO:0099092 8.96 CTNND1 CTNNB1
4 Schaffer collateral - CA1 synapse GO:0098685 8.8 SYP CTNND1 CTNNB1

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.32 NKX2-1 CTNNB1
2 negative regulation of neuron death GO:1901215 9.26 CTNNB1 CHGA
3 adherens junction organization GO:0034332 9.16 CTNND1 CTNNB1
4 epithelial tube branching involved in lung morphogenesis GO:0060441 8.96 NKX2-1 CTNNB1
5 entry of bacterium into host cell GO:0035635 8.62 CTNND1 CTNNB1

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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