MCID: PLM018
MIFTS: 35

Pulmonary Sclerosing Hemangioma

Categories: Cancer diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Sclerosing Hemangioma

MalaCards integrated aliases for Pulmonary Sclerosing Hemangioma:

Name: Pulmonary Sclerosing Hemangioma 12 43 15 71
Pneumocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5766
MeSH 43 D047868
NCIt 49 C5656
UMLS 71 C1334455

Summaries for Pulmonary Sclerosing Hemangioma

MalaCards based summary : Pulmonary Sclerosing Hemangioma, also known as pneumocytoma, is related to pulmonary blastoma and carcinoid syndrome, and has symptoms including chest pain, hemoptysis and coughing. An important gene associated with Pulmonary Sclerosing Hemangioma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are N-cadherin signaling events and E-cadherin signaling in the nascent adherens junction. The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and breast, and related phenotype is nervous system.

Related Diseases for Pulmonary Sclerosing Hemangioma

Diseases related to Pulmonary Sclerosing Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 pulmonary blastoma 30.2 SYP NKX2-1 CHGA
2 carcinoid syndrome 30.1 SYP ENO2 CHGA
3 thyroid gland medullary carcinoma 30.1 SYP ENO2 CHGA
4 hemangioma 30.1 SYP SFTPB NKX2-1 KRT7 ENO2 CHGA
5 papillary adenoma 30.0 SYP NKX2-1 KRT7
6 benign mesothelioma 29.8 KRT7 CALB2
7 adenoma 29.8 KRT7 CTNNB1 CHGA
8 pleomorphic adenoma 29.6 KRT7 CTNNB1 AR
9 sclerosing hemangioma 29.6 SYP SFTPB NKX2-1 KRT7 ENO2 CTNNB1
10 spindle cell carcinoma 29.4 SYP KRT7 ENO2 CHGA
11 carcinosarcoma 29.3 KRT7 CTNNB1 CALB2
12 sarcoma, synovial 29.1 KRT7 CTNNB1 CALB2
13 lung benign neoplasm 29.0 SYP NKX2-1 KRT7 ENO2 CHGA
14 lung cancer susceptibility 3 28.7 SFTPB NKX2-1 KRT7 CTNNB1 CALB2
15 small cell carcinoma 28.7 SYP NKX2-1 KRT7 ENO2 CHGA AR
16 teratoma 27.7 SYP NKX2-1 KRT7 ENO2 CTNNB1 CHGA
17 lung meningioma 10.5 SYP NKX2-1
18 ovarian cystic teratoma 10.4 SYP NKX2-1
19 posterior pituitary gland neoplasm 10.4 SYP NKX2-1
20 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
21 pancreas lymphoma 10.4 SYP CHGA
22 acinar cell cystadenocarcinoma 10.4 SYP CHGA
23 vulvar eccrine porocarcinoma 10.4 SYP CHGA
24 laryngeal neuroendocrine tumor 10.4 SYP CHGA
25 gastrointestinal neuroendocrine benign tumor 10.4 SYP CHGA
26 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
27 breast papillary carcinoma 10.4 SYP CHGA
28 esophageal adenoid cystic carcinoma 10.4 SYP CHGA
29 gastric neuroendocrine neoplasm 10.4 SYP CHGA
30 cervical neuroblastoma 10.4 SYP CHGA
31 classic pulmonary blastoma 10.4 NKX2-1 CTNNB1
32 pulmonary large cell neuroendocrine carcinoma 10.4 SYP CHGA
33 esophageal neuroendocrine tumor 10.4 SYP CHGA
34 respiratory distress syndrome in premature infants 10.4 SFTPB NKX2-1
35 pancreatic gastrinoma 10.4 SYP CHGA
36 gastrointestinal neuroendocrine tumor 10.4 SYP CHGA
37 pulmonary coin lesion 10.4
38 binswanger's disease 10.4 SYP CHGA
39 chordoid meningioma 10.4 SYP CHGA
40 neonatal respiratory failure 10.4 SFTPB NKX2-1
41 pancreatic acinar cell adenocarcinoma 10.4 SYP CHGA
42 extra-adrenal pheochromocytoma 10.4 SYP CHGA
43 glomangiomatosis 10.3 SYP CHGA
44 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
45 gangliocytoma 10.3 SYP CHGA
46 anal neuroendocrine tumor 10.3 SYP ENO2
47 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
48 cerebral neuroblastoma 10.3 SYP ENO2
49 papillary tumor of the pineal region 10.3 SYP ENO2
50 nodular medulloblastoma 10.3 SYP CTNNB1

Graphical network of the top 20 diseases related to Pulmonary Sclerosing Hemangioma:



Diseases related to Pulmonary Sclerosing Hemangioma

Symptoms & Phenotypes for Pulmonary Sclerosing Hemangioma

UMLS symptoms related to Pulmonary Sclerosing Hemangioma:


chest pain, hemoptysis, coughing

MGI Mouse Phenotypes related to Pulmonary Sclerosing Hemangioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.23 AR CALB2 CHGA CTNNB1 CTNND1 ENO2

Drugs & Therapeutics for Pulmonary Sclerosing Hemangioma

Drugs for Pulmonary Sclerosing Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
4 Immunologic Factors Phase 1
5 Histone Deacetylase Inhibitors Phase 1
6 Antimetabolites Phase 1
7 Androgens Phase 1
8 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Pulmonary Sclerosing Hemangioma

Cochrane evidence based reviews: pulmonary sclerosing hemangioma

Genetic Tests for Pulmonary Sclerosing Hemangioma

Anatomical Context for Pulmonary Sclerosing Hemangioma

MalaCards organs/tissues related to Pulmonary Sclerosing Hemangioma:

40
Lung, Thyroid, Breast, Ovary, Appendix, Pineal, Lymph Node

Publications for Pulmonary Sclerosing Hemangioma

Articles related to Pulmonary Sclerosing Hemangioma:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Pulmonary sclerosing pneumocytoma: Cytomorphology and immunoprofile. 61
32022435 2020
2
Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report. 61
31861007 2019
3
Sclerosing Pneumocytoma of the Lungs Arising in a Child With PTEN Mutation. 61
31166879 2019
4
Identification of the BRAF V600E mutation in a patient with sclerosing pneumocytoma: A case report. 61
31546071 2019
5
First report of pulmonary sclerosing pneomucytoma with malignant transformation in both cuboidal surface cells and stromal round cells: a case report. 61
31775674 2019
6
A case of pulmonary sclerosing pneumocytoma in the hilar lesion. 61
30488193 2019
7
AKT1 internal tandem duplications and point mutations are the genetic hallmarks of sclerosing pneumocytoma. 61
31527710 2019
8
18 F-FDG PET/CT imaging: A supplementary understanding of pulmonary sclerosing pneumocytoma. 61
31131992 2019
9
Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report. 61
31428771 2019
10
Post-tuberculosis Pneumocytoma. 61
31133161 2019
11
Symptomatic pulmonary sclerosing hemangioma: a rare case of a solitary pulmonary nodule in a woman of advanced age. 61
30971157 2019
12
Pulmonary sclerosing pneumocytoma presenting a peritumoral halo and an intervening lucent zone on computed tomography: Radiology-pathology correlation. 61
30964602 2019
13
Pulmonary sclerosing pneumocytoma presenting as slow-growing multiple nodules over a long period. 61
30891111 2019
14
Sclerosing pneumocytoma: Case report of a rare endobronchial presentation. 61
30985653 2019
15
Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature. 61
30702609 2019
16
Multifocal pulmonary mucinous cystic neoplasm with ovarian-like stroma: Once in a blue moon-case report. 61
30828544 2019
17
Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital. 61
30691016 2019
18
Pulmonary sclerosing pneumocytoma, a rare tumor of the lung. 61
30847275 2019
19
Pulmonary sclerosing pneumocytoma demonstrating intratumoral hematoma. 61
31194169 2019
20
Pulmonary Sclerosing Pneumocytoma. 61
30247298 2018
21
Tail sign: Pulmonary sclerosing pneumocytoma. 61
30309107 2018
22
WITHDRAWN:A Clinicopathologic Study of 220 Cases of Pulmonary Sclerosing Pneumocytoma in Korea: A Nationwide Survey. 61
30008196 2018
23
Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes. 61
30004067 2018
24
18F-FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma. 61
29930720 2018
25
Coexistence of glandular papilloma and sclerosing pneumocytoma in the bronchiole. 61
29696743 2018
26
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. 61
29644341 2018
27
Sclerosing pneumocytoma diagnosed by preoperative endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). 61
29524065 2018
28
A case of microscopic, multiple sclerosing pneumocytoma. 61
29451344 2018
29
Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases. 61
28881050 2018
30
[Surgical Treatment of Pseudotumours of the Lung]. 61
28641331 2018
31
Genome profile in a extremely rare case of pulmonary sclerosing pneumocytoma presenting with diffusely-scattered nodules in the right lung. 61
29236566 2018
32
[On the histo- and morphogenesis of sclerosing pneumocytoma and its diagnostic criteria]. 61
29460895 2018
33
Pulmonary Sclerosing Pneumocytoma: Did Lightening Just Strike Twice? 61
29191617 2017
34
Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis. 61
28825313 2017
35
Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer. 61
29221270 2017
36
Pneumocytoma (sclerosing hemangioma), a potential pitfall. 61
28398699 2017
37
Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes. 61
28474862 2017
38
An 111In-Pentetreotide Positive Sclerosing Pneumocytoma. 61
28166143 2017
39
Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma. 61
27902879 2017
40
Sclerosing Pneumocytoma of the Lung: A Case Report. 61
28384875 2017
41
Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature. 61
28357098 2017
42
Incidental Sclerosing Pneumocytoma Detected on Bone Scintigraphy. 61
27749415 2017
43
Single-incision video-assisted thoracoscopic surgery left-lower lobe anterior segmentectomy (S8). 61
29078674 2017
44
Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review. 61
28249927 2017
45
Benign tumor behaves malignantly: a case report of bilateral multiple pulmonary sclerosing pneumocytoma. 61
31966733 2017
46
[Multiple Pulmonary Sclerosing Pneumocytoma with Abnormal Accumulation of Fluorodeoxyglucose-positron Emission Tomography Diagnosed by Surgical Treatment;Report of a Case]. 61
27909285 2016
47
A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma. 61
27160435 2016
48
Sclerosing Pneumocytoma with Lymph Node Metastasis. 61
27346414 2016
49
Pulmonary sclerosing pneumocytoma (sclerosing haemangioma): Radical radiation therapy. 61
27302690 2016
50
Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. 61
27601661 2016

Variations for Pulmonary Sclerosing Hemangioma

Expression for Pulmonary Sclerosing Hemangioma

Search GEO for disease gene expression data for Pulmonary Sclerosing Hemangioma.

Pathways for Pulmonary Sclerosing Hemangioma

Pathways related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 CTNND1 CTNNB1
2 10.47 CTNND1 CTNNB1
3 10.13 CTNND1 CTNNB1

GO Terms for Pulmonary Sclerosing Hemangioma

Cellular components related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.26 CTNND1 CTNNB1
2 postsynaptic density, intracellular component GO:0099092 9.16 CTNND1 CTNNB1
3 presynaptic active zone cytoplasmic component GO:0098831 8.96 CTNND1 CTNNB1
4 Schaffer collateral - CA1 synapse GO:0098685 8.8 SYP CTNND1 CTNNB1

Biological processes related to Pulmonary Sclerosing Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 NKX2-1 CTNNB1
2 cellular process GO:0009987 9.32 CTNNB1 AR
3 Leydig cell differentiation GO:0033327 9.26 NKX2-1 AR
4 entry of bacterium into host cell GO:0035635 9.16 CTNND1 CTNNB1
5 epithelial cell differentiation involved in prostate gland development GO:0060742 8.96 CTNNB1 AR
6 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 8.62 CTNNB1 AR

Sources for Pulmonary Sclerosing Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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