MCID: PLM040
MIFTS: 36

Pulmonary Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Pulmonary Valve Disease

MalaCards integrated aliases for Pulmonary Valve Disease:

Name: Pulmonary Valve Disease 12 15 17
Pulmonary Valve Disorder 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5749
ICD9CM 36 424.3
NCIt 51 C78579
SNOMED-CT 69 76267008
ICD10 34 I37 I39.3
UMLS 74 C0034087

Summaries for Pulmonary Valve Disease

MalaCards based summary : Pulmonary Valve Disease, also known as pulmonary valve disorder, is related to pulmonary valve insufficiency and pulmonary valve stenosis. An important gene associated with Pulmonary Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are fMLP Pathway and ErbB signaling pathway. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are shRNA abundance <= 50% and cardiovascular system

Related Diseases for Pulmonary Valve Disease

Diseases in the Pulmonary Valve Disease family:

Pulmonary Valve Insufficiency

Diseases related to Pulmonary Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 pulmonary valve insufficiency 31.6 FLRT3 SLC6A11
2 pulmonary valve stenosis 30.4 GATA4 PTPN11 SOS1
3 rheumatic pulmonary valve disease 12.3
4 atrial septal defect 9 11.1
5 villonodular synovitis 10.1 PTPN11 SOS1
6 partial atrioventricular canal 10.0 GATA4 GATA6
7 complete atrioventricular canal-ventricle hypoplasia syndrome 10.0 GATA4 GATA6
8 neurofibromatosis-noonan syndrome 10.0 MAP2K2 PTPN11
9 costello syndrome 9.9 MAP2K2 PTPN11 SOS1
10 cardiofaciocutaneous syndrome 1 9.9 MAP2K2 PTPN11 SOS1
11 patent ductus arteriosus 1 9.9 GATA4 GATA6 PTPN11
12 carcinoid syndrome 9.7
13 pancreatic agenesis 9.7 GATA4 GATA6
14 heart septal defect 9.6 GATA4 GATA6 TBX5
15 pulmonic stenosis 9.6 GATA4 MAP2K2 PTPN11 SOS1
16 atrioventricular septal defect 9.6 GATA4 GATA6 TBX5
17 ventricular septal defect 9.6 GATA4 GATA6 TBX5
18 noonan syndrome 1 9.6 A2ML1 MAP2K2 PTPN11 SOS1
19 atrial heart septal defect 9.5 GATA4 GATA6 TBX5
20 patent foramen ovale 9.4 GATA4 GATA6 PTPN11 TBX5
21 tetralogy of fallot 9.4 GATA4 GATA6 PTPN11 TBX5
22 heart disease 9.2 GATA4 GATA6 PTPN11 SOS1 TBX5

Comorbidity relations with Pulmonary Valve Disease via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Pulmonary Valve Disease:



Diseases related to Pulmonary Valve Disease

Symptoms & Phenotypes for Pulmonary Valve Disease

GenomeRNAi Phenotypes related to Pulmonary Valve Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.23 GATA4 GATA6 MAP2K2 POLB PTPN11 SLC6A11

MGI Mouse Phenotypes related to Pulmonary Valve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 FLRT3 GATA4 GATA6 MAP2K2 POLB PTPN11
2 cellular MP:0005384 9.95 FLRT3 GATA4 GATA6 MAP2K2 POLB PTPN11
3 embryo MP:0005380 9.87 FLRT3 GATA4 GATA6 POLB PTPN11 SOS1
4 growth/size/body region MP:0005378 9.86 FLRT3 GATA4 GATA6 MAP2K2 POLB PTPN11
5 mortality/aging MP:0010768 9.81 FLRT3 GATA4 GATA6 MAP2K2 POLB PTPN11
6 digestive/alimentary MP:0005381 9.77 GATA4 MAP2K2 POLB PTPN11 SOS1
7 muscle MP:0005369 9.43 GATA4 GATA6 POLB PTPN11 SOS1 TBX5
8 skeleton MP:0005390 9.1 GATA4 MAP2K2 POLB PTPN11 SOS1 TBX5

Drugs & Therapeutics for Pulmonary Valve Disease

Drugs for Pulmonary Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved 59-92-7 6047
2
Dopamine Approved 62-31-7, 51-61-6 681
3
Cabergoline Approved 81409-90-7 54746
4 Cardiotonic Agents
5 Sympathomimetics
6 Protective Agents
7 Peripheral Nervous System Agents
8 Neurotransmitter Agents
9 Dopamine agonists
10 Dopamine Agents
11 Autonomic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcomes Following Pulmonary Valve Replacement in Adults Completed NCT00276237
2 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
3 Follow up of Post-repair Tetralogy of Fallot Completed NCT00266188
4 Pulsta® Transcatheter Pulmonary Valve Korean Multicenter Study Recruiting NCT03110861 Not Applicable
5 A Feasibility Study to Evaluate the Safety and Short-term Effectiveness of Transcatheter Pulmonary Valve (TPV) Active, not recruiting NCT02555319 Not Applicable
6 Adult Pulmonary Valve Replacement: A Simple and Reproducible Technique Terminated NCT00384163

Search NIH Clinical Center for Pulmonary Valve Disease

Genetic Tests for Pulmonary Valve Disease

Anatomical Context for Pulmonary Valve Disease

MalaCards organs/tissues related to Pulmonary Valve Disease:

42
Heart

Publications for Pulmonary Valve Disease

Articles related to Pulmonary Valve Disease:

# Title Authors Year
1
Abnormal Haemodynamic Flow Patterns in Bicuspid Pulmonary Valve Disease. ( 28620320 )
2017
2
Importance of pulmonary valve disease during implantation of a biventricular assist device. ( 24268185 )
2014
3
Tricuspid and pulmonary valve disease evaluation and management. ( 21070730 )
2010
4
Pulmonary valve replacement: extending the indications to the whole spectrum of pulmonary valve disease. ( 19804205 )
2007
5
Percutaneous stent-mounted valve for treatment of aortic or pulmonary valve disease. ( 15343576 )
2004
6
Carcinoid syndrome: an unusual cause of tricuspid and pulmonary valve disease. ( 12876616 )
2003
7
Rheumatic pulmonary valve disease. ( 11273310 )
1998
8
Echocardiographic evaluation of isolated pulmonary valve disease in adolescents and adults. ( 10146329 )
1993
9
Rheumatic pulmonary valve disease. ( 5380838 )
1969

Variations for Pulmonary Valve Disease

Expression for Pulmonary Valve Disease

Search GEO for disease gene expression data for Pulmonary Valve Disease.

Pathways for Pulmonary Valve Disease

Pathways related to Pulmonary Valve Disease according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 GATA4 GATA6 MAP2K2 SOS1
2
Show member pathways
12.4 MAP2K2 PTPN11 SOS1
3
Show member pathways
12.35 MAP2K2 PTPN11 SOS1
4
Show member pathways
12.31 MAP2K2 PTPN11 SOS1
5
Show member pathways
12.3 GATA4 GATA6 MAP2K2 SOS1
6
Show member pathways
12.25 MAP2K2 PTPN11 SOS1
7
Show member pathways
12.2 MAP2K2 PTPN11 SOS1
8
Show member pathways
12.18 MAP2K2 PTPN11 SOS1
9
Show member pathways
12.17 MAP2K2 PTPN11 SOS1
10
Show member pathways
12.15 MAP2K2 PTPN11 SOS1
11
Show member pathways
12.11 MAP2K2 PTPN11 SOS1
12 12.06 MAP2K2 PTPN11 SOS1
13
Show member pathways
12.03 MAP2K2 PTPN11 SOS1
14
Show member pathways
12.03 FLRT3 PTPN11 SOS1
15 11.93 MAP2K2 PTPN11 SOS1
16
Show member pathways
11.91 MAP2K2 PTPN11 SOS1
17
Show member pathways
11.85 MAP2K2 PTPN11 SOS1
18
Show member pathways
11.78 MAP2K2 PTPN11 SOS1
19
Show member pathways
11.63 MAP2K2 PTPN11 SOS1
20 11.6 MAP2K2 PTPN11 SOS1
21
Show member pathways
11.48 MAP2K2 PTPN11 SOS1
22 11.36 GATA4 GATA6
23 11.35 PTPN11 SOS1
24 11.34 MAP2K2 PTPN11
25 11.34 MAP2K2 POLB SOS1
26 11.31 MAP2K2 PTPN11
27 11.29 PTPN11 SOS1
28 11.28 MAP2K2 SOS1
29
Show member pathways
11.27 MAP2K2 PTPN11
30 11.26 GATA4 GATA6 MAP2K2
31 11.21 GATA4 MAP2K2 SOS1
32 11.2 PTPN11 SOS1
33
Show member pathways
11.07 PTPN11 SOS1
34 11.02 PTPN11 SOS1
35 10.98 MAP2K2 PTPN11 SOS1
36 10.95 PTPN11 SOS1
37 10.81 GATA4 MAP2K2
38
Show member pathways
10.76 MAP2K2 PTPN11 SOS1
39 10.65 MAP2K2 PTPN11 SOS1
40 10.59 GATA4 GATA6 PTPN11 TBX5

GO Terms for Pulmonary Valve Disease

Biological processes related to Pulmonary Valve Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.78 GATA4 GATA6 MAP2K2 TBX5
2 axon guidance GO:0007411 9.61 FLRT3 PTPN11 SOS1
3 positive regulation of cardiac muscle cell proliferation GO:0060045 9.51 GATA6 TBX5
4 ventricular septum development GO:0003281 9.46 GATA4 TBX5
5 neurotrophin TRK receptor signaling pathway GO:0048011 9.4 PTPN11 SOS1
6 atrial septum morphogenesis GO:0060413 9.37 GATA4 TBX5
7 cardiac muscle cell differentiation GO:0055007 9.33 GATA4 GATA6 TBX5
8 endocardial cushion development GO:0003197 9.32 GATA4 TBX5
9 intestinal epithelial cell differentiation GO:0060575 9.26 GATA4 GATA6
10 positive regulation of BMP signaling pathway GO:0030513 9.19 GATA4
11 heart development GO:0007507 9.13 FLRT3 PTPN11 TBX5
12 positive regulation of cardioblast differentiation GO:0051891 8.8 GATA4 GATA6 TBX5

Molecular functions related to Pulmonary Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enhancer sequence-specific DNA binding GO:0001158 8.32 GATA4

Sources for Pulmonary Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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