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MCID: PLM022
MIFTS: 37

Pulmonary Valve Insufficiency

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Pulmonary Valve Insufficiency

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MalaCards integrated aliases for Pulmonary Valve Insufficiency:

Name: Pulmonary Valve Insufficiency 12 44 15 73
Pulmonary Regurgitation 12 55
Pulmonary Insufficiency Following Trauma and Surgery 12
Pulmonary Incompetence, Non-Rheumatic 12
Pulmonic Valve Regurgitation 12
Pulmonary Incompetence 12
Pulmonic Insufficiency 12
Pulmonary Regurg. 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14265
MeSH 44 D011665
SNOMED-CT 68 91434003
ICD10 33 I37.1
UMLS 73 C0034088
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Summaries for Pulmonary Valve Insufficiency

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Disease Ontology : 12 A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur.

MalaCards based summary : Pulmonary Valve Insufficiency, also known as pulmonary regurgitation, is related to patent ductus arteriosus 1 and respiratory failure. An important gene associated with Pulmonary Valve Insufficiency is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways is Benzodiazepine Pathway, Pharmacodynamics. The drugs Cilastatin and Imipenem have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes.

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Related Diseases for Pulmonary Valve Insufficiency

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Diseases in the Pulmonary Valve Disease family:

Pulmonary Valve Insufficiency

Diseases related to Pulmonary Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 patent ductus arteriosus 1 29.9 NKX2-6 NPPB
2 respiratory failure 11.2
3 rheumatic pulmonary valve disease 11.0
4 ebstein anomaly 10.3 NKX2-6 NPPB
5 tricuspid valve disease 10.3 NKX2-6 NPPB
6 aortic valve insufficiency 10.3 NKX2-6 NPPB
7 pulmonary valve agenesis-intact ventricular septum-persistent ductus arteriosus syndrome 10.2
8 pulmonary valve agenesis-tetralogy of fallot-absence of ductus arteriosus syndrome 10.2
9 tricuspid valve stenosis 10.2 NKX2-6 SLC6A11
10 aortic valve disease 1 10.2 NKX2-6 NPPB
11 dextro-looped transposition of the great arteries 10.2 LEFTY2 NKX2-6
12 hypoplastic left heart syndrome 10.1 NKX2-6 NPPB
13 ventricular septal defect 10.0 NKX2-6 NPPB
14 tetralogy of fallot 10.0
15 aneurysm 9.9
16 pulmonary valve disease 9.8 FLRT3 NKX2-6 SLC6A11
17 aortic valve disease 2 9.7 NKX2-6 NPPB

Graphical network of the top 20 diseases related to Pulmonary Valve Insufficiency:



Diseases related to Pulmonary Valve Insufficiency
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Symptoms & Phenotypes for Pulmonary Valve Insufficiency

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Drugs & Therapeutics for Pulmonary Valve Insufficiency

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Drugs for Pulmonary Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 384)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
2
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
3
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
4
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-66-6 23994
5 Beractant Approved Phase 4,Phase 3 108778-82-1
6 Poractant alfa Approved Phase 4 129069-19-8
7
Riluzole Approved, Investigational Phase 4,Phase 2,Phase 3 1744-22-5 5070
8
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
11
Diclofenac Approved, Vet_approved Phase 4,Not Applicable 15307-86-5 3033
12
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
13
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
14
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068 160954
15
Menthol Approved Phase 4,Phase 1,Not Applicable 2216-51-5 16666
16
Morphine Approved, Investigational Phase 4,Phase 2,Not Applicable 57-27-2 5288826
17
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
19
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
20
Remifentanil Approved Phase 4,Phase 1,Not Applicable 132875-61-7 60815
21
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
22
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 437-38-7 3345
24
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
25
Orphenadrine Approved Phase 4 83-98-7 4601
26
Adenosine Approved, Investigational Phase 4 58-61-7 60961
27
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
28
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
29
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
30
Oxymetazoline Approved, Investigational Phase 4,Phase 2,Not Applicable 1491-59-4 4636
31
Phenylephrine Approved Phase 4,Phase 2,Not Applicable 59-42-7 6041
32
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
33
Cetirizine Approved Phase 4,Phase 3 83881-51-0 2678
34
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
35
Levocetirizine Approved Phase 4,Phase 3 130018-77-8 1549000
36
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 113775-47-6 68602 5311068
37
Hydromorphone Approved, Illicit Phase 4,Not Applicable 466-99-9 5284570
38
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
39
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
40
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
41
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
42
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
43
Fluticasone Approved, Experimental, Investigational Phase 4 90566-53-3 62924
44
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
45
Cisatracurium Approved Phase 4 96946-41-7
46 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 77-92-9 311
48 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
49 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
50 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1068)
# Name Status NCT ID Phase Drugs
1 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
2 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
3 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
4 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
5 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
6 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
7 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
8 Acupuncture for Sedation in the Intensive Care Unit (ICU) Unknown status NCT01362270 Phase 4
9 A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
10 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
11 Inspiratory Muscle Training in Hypercapnic COPD Unknown status NCT00291460 Phase 4
12 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
13 Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Unknown status NCT00560287 Phase 4
14 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Unknown status NCT01513655 Phase 4
15 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
16 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
17 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
18 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
19 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
20 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo
21 Supplemental Oxygen and Complications After Abdominal Surgery (The PROXI-trial) Completed NCT00364741 Phase 4 Oxygen
22 Ambulatory Adaptation to Non-Invasive Mechanical Ventilation Completed NCT00698958 Phase 4
23 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
24 Effect of Interscalene Block on Ventilatory Function Completed NCT01740453 Phase 4 ropivacaine 2 mg/ml
25 Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients Completed NCT01472302 Phase 4
26 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
27 Non-invasive Ventilation in Terminally Ill Cancer Patients Completed NCT00533143 Phase 4
28 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
29 Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics Completed NCT02363920 Phase 4
30 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
31 Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain Completed NCT02445599 Phase 4 Diclofenac;Midazolam;Atropine;bucain + fentanyl;Nalbuphine;Diclofenac;Metamizole-sodium;Tramadol
32 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4
33 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
34 Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
35 Inhaled Nitric Oxide by Oxygen Hood in Neonates Completed NCT00732537 Phase 4 inhaled Nitric Oxide;Oxygen (>90% by hood) - standard therapy
36 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
37 Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
38 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
39 The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine. Completed NCT02885948 Phase 4 Naloxone;Placebo
40 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients Completed NCT00355732 Phase 4
41 Helmet Ventilation in Acute Hypercapnic Respiratory Failure Completed NCT01645358 Phase 4
42 Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension Completed NCT01642407 Phase 4 Sildenafil
43 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4
44 Treatment of High Altitude Polycythemia by Acetazolamide Completed NCT00424970 Phase 4 acetazolamide
45 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
46 Effectiveness of Oxymetazoline Added on Nasal Steroid in Rhinitis With Persistent Nasal Obstruction Completed NCT01847131 Phase 4 oxymetazoline;Placebo nasal spray
47 Effects of Slow Breathing on Blood Pressure and Autonomic Function Completed NCT01390727 Phase 4
48 The Effect of Packing in Post Operative Management of FESS Completed NCT00793117 Phase 4
49 Levocetirizine in the Treatment of Nasal Obstruction Due to Perennial Allergic Rhinitis Completed NCT00439712 Phase 4 Levocetirizine;Placebo
50 Sugammadex vs. Placebo to Prevent Residual Neuromuscular Block in the Post--‐Anesthesia Care Unit Recruiting NCT02822001 Phase 4 Sugammadex;Placebo

Search NIH Clinical Center for Pulmonary Valve Insufficiency

Cochrane evidence based reviews: pulmonary valve insufficiency

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Genetic Tests for Pulmonary Valve Insufficiency

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Anatomical Context for Pulmonary Valve Insufficiency

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MalaCards organs/tissues related to Pulmonary Valve Insufficiency:

41
Lung, Heart, Testes, Brain, Liver, Spinal Cord, Bone
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Publications for Pulmonary Valve Insufficiency

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Articles related to Pulmonary Valve Insufficiency:

(show all 12)
# Title Authors Year
1
Pulmonary Valve Repair for Patients With Acquired Pulmonary Valve Insufficiency. ( 27083251 )
2016
2
Case 2/2009: eight-year-old child with pulmonary valve insufficiency and left pulmonary artery stenosis, as residual defects after tetralogy of fallot repair. ( 19360250 )
2009
3
Relief of branch pulmonary artery stenosis reduces pulmonary valve insufficiency in a swine model. ( 19619782 )
2009
4
Chronic pulmonary valve insufficiency after repaired tetralogy of Fallot: diagnostics, reoperations and reconstruction possibilities. ( 17338667 )
2007
5
Massive pulmonary valve insufficiency associated with double pulmonary artery and ascending aorta aneurysm. ( 16480029 )
2006
6
Idiopathic right pulmonary artery aneurysm with pulmonary valve insufficiency. ( 8808073 )
1996
7
Pulmonary valve insufficiency: malignant or benign? ( 1607521 )
1992
8
Repair of pulmonary valve insufficiency using an autologous monocusp. ( 3778011 )
1986
9
Diagnosis of tricuspid and pulmonary valve insufficiency by cinecardioangiography. ( 5055594 )
1972
10
Pulmonary valve insufficiency in a case of tetralogy of Fallot after Brock's operation: correction by heterologous aortic graft. ( 5166614 )
1971
11
Patent ductus arteriosus and pulmonary valve insufficiency; unusual clinical manifestations. ( 5509638 )
1970
12
Clinical recognition of congenital pulmonary valve insufficiency. ( 6058370 )
1967
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Variations for Pulmonary Valve Insufficiency

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Expression for Pulmonary Valve Insufficiency

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Search GEO for disease gene expression data for Pulmonary Valve Insufficiency.
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Pathways for Pulmonary Valve Insufficiency

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Pathways related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Benzodiazepine Pathway, Pharmacodynamics 61
Show member pathways
 9.88 SLC6A1 SLC6A11
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GO Terms for Pulmonary Valve Insufficiency

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Biological processes related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transport GO:0006836 8.96 SLC6A1 SLC6A11
2 gamma-aminobutyric acid transport GO:0015812 8.62 SLC6A1 SLC6A11

Molecular functions related to Pulmonary Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.16 SLC6A1 SLC6A11
2 symporter activity GO:0015293 8.96 SLC6A1 SLC6A11
3 gamma-aminobutyric acid:sodium symporter activity GO:0005332 8.62 SLC6A1 SLC6A11
Sources

Sources for Pulmonary Valve Insufficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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