MCID: PLM068
MIFTS: 46

Pulmonary Vein Stenosis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Vein Stenosis

MalaCards integrated aliases for Pulmonary Vein Stenosis:

Name: Pulmonary Vein Stenosis 54 74
Pulmonary Veins Stenosis 54

Classifications:



External Ids:

UMLS 74 C0340756

Summaries for Pulmonary Vein Stenosis

NIH Rare Diseases : 54 Pulmonary vein stenosis is a very rare and serious condition in which there is a blockage in the blood vessels that bring oxygen-rich blood from the lungs back to the heart. This condition can be isolated to one vein, but often affects multiple veins. Stenosis occurs when there is an abnormal thickening and narrowing of the walls of the veins. Pulmonary vein stenosis is a progressive condition and may lead to total obstruction to a blood vessel. Most commonly, all of the pulmonary veins of one lung are affected, causing pulmonary hypertension and pulmonary arterial hypertension. Surgery and catheterization to widen the narrow veins is usually a short-term solution since the obstruction typically recurs.

MalaCards based summary : Pulmonary Vein Stenosis, also known as pulmonary veins stenosis, is related to atrial fibrillation and fibroblastic rheumatism. An important gene associated with Pulmonary Vein Stenosis is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Actin Nucleation by ARP-WASP Complex. The drugs Anti-Arrhythmia Agents and Losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and bone, and related phenotypes are cellular and cardiovascular system

Wikipedia : 77 Pulmonary vein stenosis is a rare cardiovascular disorder. It is recognized as being the stenosis of... more...

Related Diseases for Pulmonary Vein Stenosis

Diseases related to Pulmonary Vein Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 atrial fibrillation 10.8
2 fibroblastic rheumatism 10.4 ACTC1 DES
3 angiolipoma 10.4 ACTC1 DES
4 cutaneous leiomyosarcoma 10.4 ACTC1 DES
5 botryoid rhabdomyosarcoma 10.4 ACTC1 DES
6 spindle cell lipoma 10.4 ACTC1 DES
7 glomangioma 10.4 ACTC1 DES
8 parachordoma 10.4 ACTC1 DES
9 syringocystadenoma papilliferum 10.4 ACTC1 DES
10 ossifying fibromyxoid tumor 10.4 ACTC1 DES
11 epithelioid leiomyosarcoma 10.4 ACTC1 DES
12 benign metastasizing leiomyoma 10.4 ACTC1 DES
13 non-langerhans-cell histiocytosis 10.4 ACTC1 DES
14 gallbladder sarcoma 10.3 DES KIT
15 cutaneous fibrous histiocytoma 10.3 ACTC1 DES
16 congenital fibrosarcoma 10.3 ACTC1 DES
17 ischemic fasciitis 10.3 ACTC1 DES
18 fasciitis 10.3 ACTC1 DES
19 reticulum cell sarcoma 10.3 ACTC1 DES
20 cystic nephroma 10.3 DES KIT
21 pseudosarcomatous fibromatosis 10.3 ACTC1 DES
22 dedifferentiated liposarcoma 10.3 ACTC1 DES
23 glomus tumor 10.3 ACTC1 DES
24 spindle cell sarcoma 10.3 ACTC1 DES
25 myxofibrosarcoma 10.3 DES MKI67
26 senile angioma 10.3 KDR KIT
27 pulmonary hypertension 10.3
28 benign breast phyllodes tumor 10.3 KIT MKI67
29 hemangiopericytoma, malignant 10.3 ACTC1 DES
30 breast adenoid cystic carcinoma 10.3 KIT MKI67
31 infantile myofibromatosis 10.3 ACTC1 DES
32 lymphangioma 10.2 ACTC1 KDR
33 chondromyxoid fibroma 10.2 ACTC1 DES
34 thymic epithelial tumor 10.2 CD99 KIT
35 hemangioendothelioma 10.2 KDR PECAM1
36 kaposiform hemangioendothelioma 10.2 KDR PECAM1
37 reticular perineurioma 10.2 KIT PDGFRA
38 8p11 myeloproliferative syndrome 10.2 KDR KIT
39 sm-ahnmd 10.2 KIT PDGFRA
40 congenital mesoblastic nephroma 10.2 KIT MKI67
41 gastric leiomyosarcoma 10.2 KIT PDGFRA
42 radiation proctitis 10.2 KDR PECAM1
43 conventional fibrosarcoma 10.2 KIT PDGFRA
44 pleomorphic liposarcoma 10.2 DES PDGFRA
45 endometrial small cell carcinoma 10.2 KIT PDGFRA
46 desmoid tumor 10.2 KIT PDGFRA
47 hypereosinophilic syndrome, idiopathic 10.2 KIT PDGFRA
48 lung adenoid cystic carcinoma 10.2 KIT PDGFRA
49 capillary hemangioma 10.2 KDR PECAM1
50 rhabdoid tumor predisposition syndrome 1 10.2 ACTC1 DES

Graphical network of the top 20 diseases related to Pulmonary Vein Stenosis:



Diseases related to Pulmonary Vein Stenosis

Symptoms & Phenotypes for Pulmonary Vein Stenosis

MGI Mouse Phenotypes related to Pulmonary Vein Stenosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 ACTC1 DES F2RL1 KDR KIT PDGFRA
2 cardiovascular system MP:0005385 9.91 ACTC1 DES F2RL1 KDR KIT PDGFRA
3 homeostasis/metabolism MP:0005376 9.86 ACTC1 DES F2RL1 KDR KIT PDGFRA
4 muscle MP:0005369 9.63 ACTC1 DES KDR KIT PDGFRA PECAM1
5 no phenotypic analysis MP:0003012 9.35 F2RL1 KDR KIT MKI67 PDGFRA
6 skeleton MP:0005390 9.1 F2RL1 KDR KIT PDGFRA PECAM1 TYMP

Drugs & Therapeutics for Pulmonary Vein Stenosis

Drugs for Pulmonary Vein Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 1,Phase 2
2
Losartan Approved Phase 1, Phase 2 114798-26-4 3961
3
Angiotensin II Approved, Investigational Phase 1, Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198
4
Vinblastine Approved Phase 2 865-21-4 241903 13342
5
leucovorin Approved Phase 2 58-05-9 143 6006
6
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
7
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
8 Orange Approved Phase 1, Phase 2
9
Amiodarone Approved, Investigational Phase 2 1951-25-3 2157
10
Propafenone Approved Phase 2 54063-53-5 4932
11
Sotalol Approved Phase 2 959-24-0, 3930-20-9 5253
12
Adenosine Approved, Investigational Phase 2 58-61-7 60961
13
Isoproterenol Approved, Investigational Phase 2 7683-59-2 3779
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
15 Angiotensin Receptor Antagonists Phase 1, Phase 2
16 Giapreza Phase 1, Phase 2
17 Angiotensin II Type 1 Receptor Blockers Phase 1, Phase 2
18 Antihypertensive Agents Phase 1, Phase 2
19 Angiotensinogen Phase 1, Phase 2
20 Antimetabolites Phase 2
21 Dermatologic Agents Phase 2
22 Antirheumatic Agents Phase 2
23 Immunosuppressive Agents Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Folate Phase 2
26 Vitamin B Complex Phase 2
27 Folic Acid Antagonists Phase 2
28 Antineoplastic Agents, Phytogenic Phase 2
29 Nucleic Acid Synthesis Inhibitors Phase 2
30 Antimitotic Agents Phase 2
31 Immunologic Factors Phase 2
32 Vitamin B9 Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2
34 Angiogenesis Inhibitors Phase 1, Phase 2
35 Antineoplastic Agents, Immunological Phase 1, Phase 2
36 Angiogenesis Modulating Agents Phase 1, Phase 2
37 Protein Kinase Inhibitors Phase 1, Phase 2
38 Imatinib Mesylate Phase 1, Phase 2 220127-57-1 123596
39 Neurotransmitter Agents Phase 2
40 Peripheral Nervous System Agents Phase 2
41 Potassium Channel Blockers Phase 2
42 Autonomic Agents Phase 2
43 Adrenergic Agents Phase 2
44 Cytochrome P-450 Enzyme Inhibitors Phase 2
45 Adrenergic Antagonists Phase 2
46 Diuretics, Potassium Sparing Phase 2
47 Sympatholytics Phase 2
48 Sodium Channel Blockers Phase 2
49 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
50 Cytochrome P-450 CYP2C9 Inhibitors Phase 2

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation Unknown status NCT00196209 Phase 4
2 Additional Linear Ablation Beyond Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation Unknown status NCT02637453 Phase 4
3 PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF) Completed NCT00774566 Phase 4
4 NAVISTAR® THERMOCOOL® Catheter Post Approval Registry Completed NCT00964392 Phase 4
5 Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation Completed NCT00678340 Phase 4
6 CRyoAblation vs AntiaRrhythmic Drugs for Persistent Atrial Fibrillation Trial Recruiting NCT03716934 Phase 4 Antiarrhythmic drug
7 Mesh Ablator Versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation Terminated NCT01061931 Phase 4
8 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
9 THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation CONTINUED ACCESS Completed NCT01639495 Phase 3
10 NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation Completed NCT00116428 Phase 3 Antiarrhythmic drug
11 nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation Terminated NCT01824394 Phase 3
12 Study of HD Mesh Ablation System for Treatment of Paroxysmal Atrial Fibrillation Terminated NCT00741611 Phase 3 Anti-arrhythmic drugs
13 NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation- Treatment Use Study Terminated NCT00721149 Phase 3
14 Pilot Trial: the Safety and Feasibility of Losartan for Pulmonary Vein Stenosis Unknown status NCT02769130 Phase 1, Phase 2 Losartan
15 Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis Completed NCT00215046 Phase 2 Vinblastine;Methotrexate
16 Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis Completed NCT00891527 Phase 1, Phase 2 Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
17 REVOLUTION (WFCC-133) - Treatment of Paroxysmal Atrial Fibrillation Completed NCT01353586 Phase 2
18 A Comparison of the Drug Therapy Versus Re-Ablation Completed NCT01709682 Phase 2 Anti-Arrhythmia Agents (propafenone, flecainide, and/or sotalol, or amiodarone)
19 Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation Completed NCT03032965 Phase 2 Adenosine;Isoproterenol
20 Treatment of Atrial Fibrillation by Minimal Invasive Surgery Completed NCT00448656 Phase 2
21 RF Ablation of Atrial Fibrillation Completed NCT00265629 Phase 1
22 Irrigated Ablation System Evaluation for Atrial Fibrillation (AF) Completed NCT01056328 Not Applicable
23 Safety Monitoring of Patients Having Pulmonary Vein Ablation Completed NCT00590668
24 Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP) Completed NCT01661205 Not Applicable
25 Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation Completed NCT01687166 Not Applicable
26 Continued Access Protocol Completed NCT00889681 Not Applicable
27 The Effect of Early Repeat Atrial Fibrillation (AF) Ablation on AF Recurrence Completed NCT01942408 Not Applicable
28 RF Power, LSI and Oesophageal Temperature Alerts During AF Ablation (PiLOT-AF Study) Completed NCT02619396 Not Applicable
29 Cryoballoon Pulmonary Venous Isolation in Patients Referred for Typical Atrial Flutter Ablation Completed NCT01521988 Not Applicable
30 Allogeneic Left Atrial and Pulmonary Vein Transplant for Pulmonary Vein Stenosis Recruiting NCT03456193 Not Applicable
31 Pulmonary Vein Isolation in Athletes Recruiting NCT03226847 Not Applicable
32 DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation Recruiting NCT03643224 Not Applicable
33 Cryoablation System FIM/CE Mark Study Recruiting NCT03723070 Not Applicable
34 Cryoballoon Atrial Fibrillation Ablation Registry Recruiting NCT03040037
35 Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by Multimodal Echocardiographic Techniques Recruiting NCT02838914 Not Applicable
36 Half-normal Saline in Atrial Fibrillation Ablation Recruiting NCT03498586 Not Applicable Half-normal saline;Normal saline
37 CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF Recruiting NCT02696265 Not Applicable
38 Effectiveness Study of Circumferential vs. Segmental Ablation in Paroxysmal Atrial Fibrillation Active, not recruiting NCT02106663 Not Applicable
39 Safety and Performance of a GLOBAL Mapping and Ablation Device for the Treatment of Atrial Fibrillation (GLOBAL-AF) Active, not recruiting NCT02168972 Not Applicable
40 TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation Active, not recruiting NCT03354663 Not Applicable
41 Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation. Active, not recruiting NCT03459196 Not Applicable
42 STOP Persistent AF Active, not recruiting NCT03012841 Not Applicable
43 Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro) Active, not recruiting NCT02944968 Not Applicable
44 AF Ablation With the Ablation Index Not yet recruiting NCT03634592
45 Measurement of Angiogenic Related Growth Factors in Urine and Blood From Patients With Pulmonary Vein Stenosis Terminated NCT00215059
46 Use of the Hansen Medical System in Patients With Paroxysmal Atrial Fibrillation Terminated NCT01122173 Not Applicable
47 Evaluation of the Phased Radio Frequency Ablation System Terminated NCT01693120 Not Applicable

Search NIH Clinical Center for Pulmonary Vein Stenosis

Genetic Tests for Pulmonary Vein Stenosis

Anatomical Context for Pulmonary Vein Stenosis

MalaCards organs/tissues related to Pulmonary Vein Stenosis:

42
Heart, Lung, Bone, Skin, Bone Marrow, Smooth Muscle

Publications for Pulmonary Vein Stenosis

Articles related to Pulmonary Vein Stenosis:

(show top 50) (show all 313)
# Title Authors Year
1
Catheter ablation for atrial fibrillation and intervention for pulmonary vein stenosis in a patient with Fontan circulation. ( 30264868 )
2019
2
Proximal Isovelocity Surface Area Method for Diagnosing Isolated Pulmonary Vein Stenosis in a Case of Complete Atrioventricular Septal Defect With Increased Pulmonary Venous Blood Flow. ( 30272591 )
2019
3
Metakaryotic cells linked to pediatric pulmonary vein stenosis. ( 30660022 )
2019
4
Pulmonary vein stenosis after valve replacement surgery. ( 30819516 )
2019
5
The use of lobectomy for management of clinically significant pulmonary vein stenosis and occlusion refractory to percutaneous intervention. ( 30937281 )
2019
6
Comparison of drug eluting versus bare metal stents for pulmonary vein stenosis in childhood. ( 31067002 )
2019
7
Complex cases of acquired pulmonary vein stenosis after radiofrequency ablation: is surgical repair an option? ( 29444219 )
2019
8
Anomalous Pulmonary Venous Drainage and Pulmonary Vein Stenosis. ( 29655764 )
2019
9
Pulmonary Vein Stenosis After Catheter Ablation for Atrial Fibrillation: Preventing a Devastating Complication With Intracardiac Echocardiography. ( 30573063 )
2018
10
Reply: Pulmonary Vein Stenosis After Catheter Ablation for Atrial Fibrillation: Preventing a Devastating Complication With Intracardiac Echocardiography. ( 30573064 )
2018
11
Rate of acquired pulmonary vein stenosis after ablation of atrial fibrillation referred to electroanatomical mapping systems: Does it matter? ( 30246235 )
2018
12
Angioplasty Versus Stenting for Pulmonary Vein Stenosis After Radiofrequency Ablation for Atrial Fibrillation-A Systemic Review and Meta-analysis. ( 30188876 )
2018
13
Acquired Pulmonary Vein Stenosis After Radiofrequency Ablation for Atrial Fibrillation: Single-Center Experience in Catheter Interventional Treatment. ( 30139470 )
2018
14
Pulmonary Vein Stenosis and Occlusion Following Catheter Ablation of Atrial Fibrillation: Still Worth Worrying About? ( 30139472 )
2018
15
Letter by Schuster Regarding Article, "Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation". ( 29986948 )
2018
16
Progressive pulmonary vein stenosis in Down syndrome infant: a rare cause of pulmonary hypertension. ( 29703879 )
2018
17
Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )
2018
18
Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity. ( 30278272 )
2018
19
The impact of right ventricular pressure and function on survival in patients with pulmonary vein stenosis. ( 29708022 )
2018
20
Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation. ( 29752377 )
2018
21
Pulmonary Vein Stenosis After Atrial Fibrillation Ablation: An Iatrogenic Problem Larger Than the Primary Problem. ( 29752378 )
2018
22
Key technical steps in dual-pathway repair of congenital pulmonary vein stenosis. ( 29860897 )
2018
23
A Case With Pulmonary Vein Stenosis and Obstruction After Pulmonary Vein Isolation: A Multimodality Approach. ( 30025700 )
2018
24
Radiologic review of acquired pulmonary vein stenosis in adults. ( 30057885 )
2018
25
Does second-generation cryoballoon ablation using the current single short freeze strategy produce pulmonary vein stenosis? ( 30093139 )
2018
26
Hybrid Pulmonary Vein Stenting in Infants with Refractory to Surgical Pulmonary Vein Stenosis Repair. ( 30105463 )
2018
27
Intraluminal Pulmonary Vein Stenosis in Children: A "New" Lesion. ( 30451723 )
2018
28
Cracking the Mystery of Pulmonary Vein Stenosis. ( 30476534 )
2018
29
Pulmonary Vein Stenosis in a Patient With Takayasu Arteritis. ( 30570489 )
2018
30
Pulmonary vein stenosis with collateralization via esophageal varices: Long-term follow-up after successful treatment with drug-eluting stent. ( 28924998 )
2018
31
Pulmonary vein stenosis or occlusion after catheter ablation of atrial fibrillation: long-term comparison of drug-eluting versus large bare metal stents. ( 29069364 )
2018
32
Balloon angioplasty versus stenting for pulmonary vein stenosis after pulmonary vein isolation for atrial fibrillation: A meta-analysis. ( 29273240 )
2018
33
Spontaneous massive hemothorax presenting as a late complication of stent implantation in a patient with pulmonary vein stenosis following radiofrequency ablation for atrial fibrillation. ( 29325041 )
2018
34
Head-to-head comparison of acute and chronic pulmonary vein stenosis for cryoballoon versus radiofrequency ablation. ( 29380388 )
2018
35
Freedom from pulmonary vein stenosis after multiple applications of epicardial ablation energy. ( 29522104 )
2018
36
New Paradigms for Pulmonary Vein Stenosis Treatment: When Surgery and Transcatheter Therapy Aren't Good Enough. ( 29551312 )
2018
37
Outcomes and prognostic factors for postsurgical pulmonary vein stenosis in the current era. ( 29576261 )
2018
38
Adjunct Targeted Biologic Inhibition Agents to Treat Aggressive Multivessel Intraluminal Pediatric Pulmonary Vein Stenosis. ( 29576325 )
2018
39
Anatomical and procedural predictors of pulmonary vein stenosis in the setting of second-generation cryoballoon ablation. ( 29601309 )
2018
40
Low Risk of Pulmonary Vein Stenosis After Contemporary Atrial Fibrillation Ablation - Lessons From Repeat Procedures After Radiofrequency Current, Cryoballoon, and Laser Balloon. ( 29618679 )
2018
41
Pulmonary Vein Stenosis in Infants: A Systematic Review, Meta-Analysis, and Meta-Regression. ( 29650415 )
2018
42
Long-term follow-up in patients treated by stent implantation for post-ablation pulmonary vein stenosis. ( 29671104 )
2018
43
A case report regarding general anesthesia management of a patient with pulmonary vein stenosis that underwent balloon dilatation and stent implantation. ( 29702994 )
2018
44
Pulmonary veins stenosis after catheter ablation of atrial fibrillation as the cause of haemoptysis: three cases and a literature review. ( 27216646 )
2018
45
Pulmonary veins stenosis relief after an inappropriate radiofrequency catheter ablation of atrial fibrillation in a young non-competitive athlete. ( 29557576 )
2018
46
Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. ( 28152279 )
2017
47
Incidence of Pulmonary Vein Stenosis After Radiofrequency Catheter Ablation of Atrial Fibrillation. ( 29759432 )
2017
48
Pulmonary Vein Stenosis Following Radiofrequency Ablation of Atrial Fibrillation: Has It Become a Clinically Negligible Complication? ( 29759433 )
2017
49
Pulmonary Vein Varix with Pulmonary Vein Stenosis. ( 28007075 )
2017
50
Pulmonary Vein Stenosis After Second-Generation Cryoballoon Ablation. ( 28032927 )
2017

Variations for Pulmonary Vein Stenosis

Expression for Pulmonary Vein Stenosis

Search GEO for disease gene expression data for Pulmonary Vein Stenosis.

Pathways for Pulmonary Vein Stenosis

GO Terms for Pulmonary Vein Stenosis

Cellular components related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CD99 F2RL1 KDR KIT PDGFRA
2 receptor complex GO:0043235 8.8 KDR KIT PDGFRA

Biological processes related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 KDR PECAM1 TYMP
2 extracellular matrix organization GO:0030198 9.71 KDR PDGFRA PECAM1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.69 KDR KIT PDGFRA
4 protein autophosphorylation GO:0046777 9.67 KDR KIT PDGFRA
5 positive regulation of MAPK cascade GO:0043410 9.61 KDR KIT PDGFRA
6 muscle filament sliding GO:0030049 9.57 ACTC1 DES
7 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.55 KIT PDGFRA
8 negative regulation of apoptotic process GO:0043066 9.52 ACTC1 KDR
9 cardiac myofibril assembly GO:0055003 9.48 ACTC1 PDGFRA
10 embryonic hemopoiesis GO:0035162 9.46 KDR KIT
11 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.46 F2RL1 KDR KIT PDGFRA
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 KDR KIT PDGFRA
13 positive regulation of phospholipase C activity GO:0010863 9.4 KIT PDGFRA
14 positive regulation of pseudopodium assembly GO:0031274 9.37 F2RL1 KIT
15 positive regulation of positive chemotaxis GO:0050927 9.32 F2RL1 KDR
16 positive regulation of cell migration GO:0030335 9.26 F2RL1 KDR KIT PDGFRA
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.92 F2RL1 KDR KIT PDGFRA

Molecular functions related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.72 ACTC1 KDR KIT MKI67 PDGFRA
2 protein tyrosine kinase activity GO:0004713 9.43 KDR KIT PDGFRA
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 KDR PDGFRA
4 vascular endothelial growth factor binding GO:0038085 8.96 KDR PDGFRA
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 KDR KIT PDGFRA

Sources for Pulmonary Vein Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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