MCID: PLM068
MIFTS: 43

Pulmonary Vein Stenosis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Pulmonary Vein Stenosis

MalaCards integrated aliases for Pulmonary Vein Stenosis:

Name: Pulmonary Vein Stenosis 53 73
Pulmonary Veins Stenosis 53

Classifications:



External Ids:

UMLS 73 C0340756

Summaries for Pulmonary Vein Stenosis

NIH Rare Diseases : 53 Pulmonary vein stenosis is a very rare and serious condition in which there is a blockage in the blood vessels that bring oxygen-rich blood from the lungs back to the heart. This condition can be isolated to one vein, but often affects multiple veins. Stenosis occurs when there is an abnormal thickening and narrowing of the walls of the veins. Pulmonary vein stenosis is a progressive condition and may lead to total obstruction to a blood vessel. Most commonly, all of the pulmonary veins of one lung are affected, causing pulmonary hypertension and pulmonary arterial hypertension. Surgery and catheterization to widen the narrow veins is usually a short-term solution since the obstruction typically recurs.

MalaCards based summary : Pulmonary Vein Stenosis, also known as pulmonary veins stenosis, is related to reticular perineurioma and sm-ahnmd. An important gene associated with Pulmonary Vein Stenosis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are p70S6K Signaling and Tyrosine Kinases / Adaptors. The drugs Menthol and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Pulmonary vein stenosis is a rare cardiovascular disorder. It is recognized as being the stenosis of one... more...

Related Diseases for Pulmonary Vein Stenosis

Diseases related to Pulmonary Vein Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 reticular perineurioma 10.7 KIT PDGFRA
2 sm-ahnmd 10.6 KIT PDGFRA
3 gastric leiomyosarcoma 10.6 KIT PDGFRA
4 atrial fibrillation 10.6
5 desmoid tumor 10.6 KIT PDGFRA
6 sarcomatoid renal cell carcinoma 10.6 KIT PDGFRA
7 conventional fibrosarcoma 10.6 KIT PDGFRA
8 endometrial small cell carcinoma 10.6 KIT PDGFRA
9 hypereosinophilic syndrome, idiopathic 10.6 KIT PDGFRA
10 benign breast phyllodes tumor 10.6 KIT MKI67
11 hemangioendothelioma 10.6 KDR PECAM1
12 kaposiform hemangioendothelioma 10.6 KDR PECAM1
13 undifferentiated pleomorphic sarcoma 10.6 KIT PDGFRA
14 lung adenoid cystic carcinoma 10.6 KIT PDGFRA
15 carney triad 10.6 KIT PDGFRA
16 capillary hemangioma 10.6 KDR PECAM1
17 heart sarcoma 10.6 KIT PDGFRA
18 radiation proctitis 10.6 KDR PECAM1
19 chronic eosinophilic leukemia 10.6 KIT PDGFRA
20 epithelioid hemangioendothelioma 10.5 KDR PECAM1
21 mesenchymal cell neoplasm 10.5 KIT PDGFRA
22 cervical adenosquamous carcinoma 10.5 KDR PDGFRA
23 neurofibromatosis, type i 10.5 KIT PDGFRA
24 congenital mesoblastic nephroma 10.5 KIT MKI67
25 myxofibrosarcoma 10.5 DES MKI67
26 fibroblastic rheumatism 10.5 ACTC1 DES
27 angiolipoma 10.5 ACTC1 DES
28 cutaneous leiomyosarcoma 10.5 ACTC1 DES
29 botryoid rhabdomyosarcoma 10.5 ACTC1 DES
30 spindle cell lipoma 10.4 ACTC1 DES
31 parachordoma 10.4 ACTC1 DES
32 ossifying fibromyxoid tumor 10.4 ACTC1 DES
33 senile angioma 10.4 KDR KIT
34 epithelioid leiomyosarcoma 10.4 ACTC1 DES
35 syringocystadenoma papilliferum 10.4 ACTC1 DES
36 benign metastasizing leiomyoma 10.4 ACTC1 DES
37 thymic epithelial tumor 10.4 CD99 KIT
38 congenital fibrosarcoma 10.4 ACTC1 DES
39 gallbladder sarcoma 10.4 DES KIT
40 pleomorphic liposarcoma 10.4 ACTC1 DES
41 ischemic fasciitis 10.4 ACTC1 DES
42 reticulum cell sarcoma 10.4 ACTC1 DES
43 dedifferentiated liposarcoma 10.4 ACTC1 DES
44 cutaneous fibrous histiocytoma 10.4 ACTC1 DES
45 spinal chordoma 10.4 KDR PDGFRA
46 lymphangioma 10.4 ACTC1 KDR
47 glomus tumor 10.4 ACTC1 DES
48 8p11 myeloproliferative syndrome 10.3 KDR KIT
49 spindle cell sarcoma 10.3 ACTC1 DES
50 non-langerhans-cell histiocytosis 10.3 ACTC1 DES

Graphical network of the top 20 diseases related to Pulmonary Vein Stenosis:



Diseases related to Pulmonary Vein Stenosis

Symptoms & Phenotypes for Pulmonary Vein Stenosis

MGI Mouse Phenotypes related to Pulmonary Vein Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 TYMP KDR KIT PDGFRA ACTC1 PECAM1
2 cardiovascular system MP:0005385 9.91 F2RL1 KDR KIT PDGFRA ACTC1 PECAM1
3 homeostasis/metabolism MP:0005376 9.86 TYMP F2RL1 KDR KIT PDGFRA ACTC1
4 muscle MP:0005369 9.63 KDR KIT PDGFRA ACTC1 PECAM1 DES
5 no phenotypic analysis MP:0003012 9.35 F2RL1 KDR KIT MKI67 PDGFRA
6 skeleton MP:0005390 9.1 TYMP F2RL1 KDR KIT PDGFRA PECAM1

Drugs & Therapeutics for Pulmonary Vein Stenosis

Drugs for Pulmonary Vein Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2 Anti-Arrhythmia Agents Phase 3,Phase 2,Phase 1
3
Propafenone Approved Phase 2 54063-53-5 4932
4
Sotalol Approved Phase 2 959-24-0, 3930-20-9 5253
5
Vinblastine Approved Phase 2 865-21-4 13342 241903
6
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
7
Amiodarone Approved, Investigational Phase 2 1951-25-3 2157
8
Isoproterenol Approved, Investigational Phase 2 7683-59-2 3779
9
Adenosine Approved, Investigational Phase 2 58-61-7 60961
10
Losartan Approved Phase 1, Phase 2 114798-26-4 3961
11
Angiotensin II Approved, Investigational Phase 1, Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
12
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
13
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
15 Orange Approved, Nutraceutical Phase 1, Phase 2
16 Analgesics Phase 2
17 Respiratory System Agents Phase 2
18 Adrenergic Agents Phase 2
19 Adrenergic Agonists Phase 2
20 Folic Acid Antagonists Phase 2
21 Adrenergic Antagonists Phase 2
22 Adrenergic beta-Agonists Phase 2
23 Adrenergic beta-Antagonists Phase 2
24 Sodium Channel Blockers Phase 2
25 Sympatholytics Phase 2
26 Neurotransmitter Agents Phase 2
27 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
28 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
29 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
30 Cytochrome P-450 CYP3A Inhibitors Phase 2
31 Cytochrome P-450 Enzyme Inhibitors Phase 2
32 Dermatologic Agents Phase 2
33 Nucleic Acid Synthesis Inhibitors Phase 2
34 Diuretics, Potassium Sparing Phase 2
35 Vasodilator Agents Phase 2
36 Anti-Asthmatic Agents Phase 2
37 Peripheral Nervous System Agents Phase 2
38 Vitamin B Complex Phase 2
39 Immunosuppressive Agents Phase 2
40 Potassium Channel Blockers Phase 2
41 Protective Agents Phase 2
42 Antirheumatic Agents Phase 2
43 Antimetabolites Phase 2
44 Autonomic Agents Phase 2
45 Bronchodilator Agents Phase 2
46 Antimetabolites, Antineoplastic Phase 2
47 Antimitotic Agents Phase 2
48 Antineoplastic Agents, Phytogenic Phase 2
49 Angiotensin II Type 1 Receptor Blockers Phase 1, Phase 2
50 Angiotensin Receptor Antagonists Phase 1, Phase 2

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation Unknown status NCT00196209 Phase 4
2 PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF) Completed NCT00774566 Phase 4
3 Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation Completed NCT00678340 Phase 4
4 Additional Linear Ablation Beyond Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation Recruiting NCT02637453 Phase 4
5 NAVISTAR® THERMOCOOL® Catheter Post Approval Registry Active, not recruiting NCT00964392 Phase 4
6 Mesh Ablator Versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation Terminated NCT01061931 Phase 4
7 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
8 THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation CONTINUED ACCESS Completed NCT01639495 Phase 3
9 NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation Completed NCT00116428 Phase 3 Antiarrhythmic drug
10 Study of HD Mesh Ablation System for Treatment of Paroxysmal Atrial Fibrillation Terminated NCT00741611 Phase 3 Anti-arrhythmic drugs
11 NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation- Treatment Use Study Terminated NCT00721149 Phase 3
12 Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis Completed NCT00215046 Phase 2 Vinblastine;Methotrexate
13 REVOLUTION (WFCC-133) - Treatment of Paroxysmal Atrial Fibrillation Completed NCT01353586 Phase 2
14 A Comparison of the Drug Therapy Versus Re-Ablation Completed NCT01709682 Phase 2 Anti-Arrhythmia Agents (propafenone, flecainide, and/or sotalol, or amiodarone)
15 Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation Completed NCT03032965 Phase 2 Adenosine;Isoproterenol
16 Treatment of Atrial Fibrillation by Minimal Invasive Surgery Completed NCT00448656 Phase 2
17 Pilot Trial: the Safety and Feasibility of Losartan for Pulmonary Vein Stenosis Recruiting NCT02769130 Phase 1, Phase 2 Losartan
18 Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis Active, not recruiting NCT00891527 Phase 1, Phase 2 Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
19 RF Ablation of Atrial Fibrillation Completed NCT00265629 Phase 1
20 Irrigated Ablation System Evaluation for Atrial Fibrillation (AF) Completed NCT01056328 Not Applicable
21 Safety Monitoring of Patients Having Pulmonary Vein Ablation Completed NCT00590668
22 Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP) Completed NCT01661205 Not Applicable
23 Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation Completed NCT01687166 Not Applicable
24 Continued Access Protocol Completed NCT00889681 Not Applicable
25 The Effect of Early Repeat Atrial Fibrillation (AF) Ablation on AF Recurrence Completed NCT01942408 Not Applicable
26 RF Power, LSI and Oesophageal Temperature Alerts During AF Ablation (PiLOT-AF Study) Completed NCT02619396 Not Applicable
27 Cryoballoon Pulmonary Venous Isolation in Patients Referred for Typical Atrial Flutter Ablation Completed NCT01521988 Not Applicable
28 Effectiveness Study of Circumferential vs. Segmental Ablation in Paroxysmal Atrial Fibrillation Recruiting NCT02106663 Not Applicable
29 Pulmonary Vein Isolation in Athletes Recruiting NCT03226847 Not Applicable
30 Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation. Recruiting NCT03459196 Not Applicable
31 STOP Persistent AF Recruiting NCT03012841 Not Applicable
32 Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro) Recruiting NCT02944968 Not Applicable
33 Cryoballoon Atrial Fibrillation Ablation Registry Recruiting NCT03040037
34 Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by Multimodal Echocardiographic Techniques Recruiting NCT02838914 Not Applicable
35 CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF Recruiting NCT02696265 Not Applicable
36 Safety and Performance of a GLOBAL Mapping and Ablation Device for the Treatment of Atrial Fibrillation (GLOBAL-AF) Active, not recruiting NCT02168972 Not Applicable
37 TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation Active, not recruiting NCT03354663 Not Applicable
38 Allogeneic Left Atrial and Pulmonary Vein Transplant for Pulmonary Vein Stenosis Not yet recruiting NCT03456193 Not Applicable
39 Half-normal Saline in Atrial Fibrillation Ablation Not yet recruiting NCT03498586 Not Applicable Half-normal saline;Normal saline
40 Measurement of Angiogenic Related Growth Factors in Urine and Blood From Patients With Pulmonary Vein Stenosis Terminated NCT00215059
41 Evaluation of the Phased Radio Frequency Ablation System Terminated NCT01693120 Not Applicable

Search NIH Clinical Center for Pulmonary Vein Stenosis

Genetic Tests for Pulmonary Vein Stenosis

Anatomical Context for Pulmonary Vein Stenosis

MalaCards organs/tissues related to Pulmonary Vein Stenosis:

41
Lung, Heart

Publications for Pulmonary Vein Stenosis

Articles related to Pulmonary Vein Stenosis:

(show top 50) (show all 281)
# Title Authors Year
1
Head-to-head comparison of acute and chronic pulmonary vein stenosis for cryoballoon versus radiofrequency ablation. ( 29380388 )
2018
2
Anomalous Pulmonary Venous Drainage and Pulmonary Vein Stenosis. ( 29655764 )
2018
3
Key technical steps in dual-pathway repair of congenital pulmonary vein stenosis. ( 29860897 )
2018
4
Pulmonary Vein Stenosis in Infants: A Systematic Review, Meta-Analysis, and Meta-Regression. ( 29650415 )
2018
5
Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )
2018
6
Complex cases of acquired pulmonary vein stenosis after radiofrequency ablation: is surgical repair an option? ( 29444219 )
2018
7
Outcomes and prognostic factors for postsurgical pulmonary vein stenosis in the current era. ( 29576261 )
2018
8
A case report regarding general anesthesia management of a patient with pulmonary vein stenosis that underwent balloon dilatation and stent implantation. ( 29702994 )
2018
9
Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation. ( 29752377 )
2018
10
Freedom from pulmonary vein stenosis after multiple applications of epicardial ablation energy. ( 29522104 )
2018
11
Low Risk of Pulmonary Vein Stenosis After Contemporary Atrial Fibrillation Ablationa88- Lessons From Repeat Procedures After Radiofrequency Current, Cryoballoon, and Laser Balloon. ( 29618679 )
2018
12
Spontaneous massive hemothorax presenting as a late complication of stent implantation in a patient with pulmonary vein stenosis following radiofrequency ablation for atrial fibrillation. ( 29325041 )
2018
13
Pulmonary Vein Stenosis After Atrial Fibrillation Ablation: An Iatrogenic Problem Larger Than the Primary Problem. ( 29752378 )
2018
14
New Paradigms for Pulmonary Vein Stenosis Treatment: When Surgery and Transcatheter Therapy Aren't Good Enough. ( 29551312 )
2018
15
The impact of right ventricular pressure and function on survival in patients with pulmonary vein stenosis. ( 29708022 )
2018
16
Long-term follow-up in patients treated by stent implantation for post-ablation pulmonary vein stenosis. ( 29671104 )
2018
17
Adjunct Targeted Biologic Inhibition Agents to Treat Aggressive Multivessel Intraluminal Pediatric Pulmonary Vein Stenosis. ( 29576325 )
2018
18
Progressive pulmonary vein stenosis in Down syndrome infant: a rare cause of pulmonary hypertension. ( 29703879 )
2018
19
Anatomical and procedural predictors of pulmonary vein stenosis in the setting of second-generation cryoballoon ablation. ( 29601309 )
2018
20
Balloon angioplasty versus stenting for pulmonary vein stenosis after pulmonary vein isolation for atrial fibrillation: A meta-analysis. ( 29273240 )
2018
21
Persistent Oxygen Requirement beyond Prematurity: A Case of Acquired Pulmonary Vein Stenosis. ( 28392954 )
2017
22
Congenital Pulmonary Vein Stenosis and Pulmonary Artery Branch Stenosis: A Rare Combination. ( 28465986 )
2017
23
Real-time three dimensional CT and MRI to guide interventions for congenital heart disease and acquired pulmonary vein stenosis. ( 28455631 )
2017
24
Pulmonary Vein Widening Plasty for Pulmonary Vein Stenosis and Occlusion After Catheter Ablation. ( 29054242 )
2017
25
Successful Percutaneous Stenting of Severe Radiofrequency-Induced Pulmonary Vein Stenosis in 3 Veins Post-Failed Surgical Correction. ( 28109876 )
2017
26
Pulmonary Vein Stenosis Following Single-Lung Transplantation Successfully Treated with Intravascular Ultrasound-Guided Angioplasty and Stent Placement. ( 29203761 )
2017
27
Pulmonary Vein Varix with Pulmonary Vein Stenosis. ( 28007075 )
2017
28
Primary Pulmonary Vein Stenosis: Outcomes, Risk Factors, and Severity Score in a Multicentric Study. ( 28633223 )
2017
29
Pulmonary vein stenosis in patients with Smith-Lemli-Opitz syndrome. ( 28719049 )
2017
30
Surgical Repair for the Treatment of Pulmonary Vein Stenosis After Radiofrequency Ablation. ( 28838520 )
2017
31
Pulmonary vein stenosis after second-generation cryoballoon ablation for atrial fibrillation. ( 28491764 )
2017
32
Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients. ( 28622179 )
2017
33
A History Lesson: Pulmonary Vein Stenosis. ( 28522385 )
2017
34
Impact of Radiofrequency Ablation of Atrial Fibrillation on Pulmonary Vein Cross Sectional Area: Implications for the Diagnosis of Pulmonary Vein Stenosis. ( 29250220 )
2017
35
Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. ( 28152279 )
2017
36
Letter by Jazayeri et al Regarding Article, "Severe Pulmonary Vein Stenosis Resulting From Ablation for Atrial Fibrillation: Presentation, Management, and Clinical Outcomes". ( 28461423 )
2017
37
Pulmonary Vein Stenosis Following Radiofrequency Ablation of AtrialA Fibrillation: Has It Become a Clinically Negligible Complication? ( 29759433 )
2017
38
Pulmonary vein stenosis or occlusion after catheter ablation of atrial fibrillation: long-term comparison of drug-eluting versus large bare metal stents. ( 29069364 )
2017
39
Response by Fender et al to Letter Regarding Article, "Severe Pulmonary Vein Stenosis Resulting From Ablation for Atrial Fibrillation: Presentation, Management, and Clinical Outcomes". ( 28461424 )
2017
40
Recurrent haemoptysis as a symptom of severe pulmonary vein stenosis-a rare complication of catheter ablation in atrial fibrillation. ( 28096996 )
2017
41
Computed Tomographic and Fluoroscopic Image Fusion for Pulmonary Vein Stenosis Stenting. ( 28843331 )
2017
42
Pulmonary vein stenosis with collateralization via esophageal varices: Long-term follow-up after successful treatment with drug-eluting stent. ( 28924998 )
2017
43
Incidence of Pulmonary Vein Stenosis After Radiofrequency Catheter Ablation of AtrialA Fibrillation. ( 29759432 )
2017
44
Correction to: Severe Pulmonary Vein Stenosis Resulting From Ablation for Atrial Fibrillation: Presentation, Management, and Clinical Outcomes. ( 28461425 )
2017
45
Pulmonary vein stenosis: Etiology, diagnosis and management. ( 26839659 )
2016
46
Surgical approaches to pulmonary vein stenosis in pediatric heart transplant recipients: Opportunity for success in a difficult situation. ( 27453521 )
2016
47
Pulmonary Vein Stenosis in Neonates with Severe Bronchopulmonary Dysplasia. ( 26862723 )
2016
48
Recurrent Pulmonary Vein Stenosis After Pulmonary Vein Isolation. ( 28041807 )
2016
49
Pulmonary Vein Stenosis After Second-Generation Cryoballoon Ablation. ( 28032927 )
2016
50
Pulmonary vein stenosis after atrial fibrillation ablation. ( 27174109 )
2016

Variations for Pulmonary Vein Stenosis

Expression for Pulmonary Vein Stenosis

Search GEO for disease gene expression data for Pulmonary Vein Stenosis.

Pathways for Pulmonary Vein Stenosis

GO Terms for Pulmonary Vein Stenosis

Cellular components related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CD99 F2RL1 KDR KIT PDGFRA
2 receptor complex GO:0043235 8.8 KDR KIT PDGFRA

Biological processes related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 ACTC1 KDR KIT PDGFRA
2 extracellular matrix organization GO:0030198 9.74 KDR PDGFRA PECAM1
3 protein autophosphorylation GO:0046777 9.71 KDR KIT PDGFRA
4 peptidyl-tyrosine phosphorylation GO:0018108 9.7 KDR KIT PDGFRA
5 positive regulation of MAPK cascade GO:0043410 9.69 KDR KIT PDGFRA
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.63 KDR KIT PDGFRA
7 negative regulation of signal transduction GO:0009968 9.61 KDR KIT PDGFRA
8 muscle filament sliding GO:0030049 9.58 ACTC1 DES
9 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.56 KIT PDGFRA
10 cardiac myofibril assembly GO:0055003 9.49 ACTC1 PDGFRA
11 embryonic hemopoiesis GO:0035162 9.48 KDR KIT
12 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.46 F2RL1 KDR KIT PDGFRA
13 positive regulation of kinase activity GO:0033674 9.43 KDR KIT PDGFRA
14 positive regulation of pseudopodium assembly GO:0031274 9.4 F2RL1 KIT
15 positive regulation of positive chemotaxis GO:0050927 9.37 F2RL1 KDR
16 positive regulation of phospholipase C activity GO:0010863 9.32 KIT PDGFRA
17 positive regulation of cell migration GO:0030335 9.26 F2RL1 KDR KIT PDGFRA
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.92 F2RL1 KDR KIT PDGFRA

Molecular functions related to Pulmonary Vein Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.61 KDR KIT PDGFRA
2 MAP kinase kinase kinase activity GO:0004709 9.54 KDR KIT PDGFRA
3 mitogen-activated protein kinase kinase binding GO:0031434 9.43 KDR KIT PDGFRA
4 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.4 KDR KIT
5 vascular endothelial growth factor-activated receptor activity GO:0005021 9.32 KDR PDGFRA
6 vascular endothelial growth factor binding GO:0038085 9.16 KDR PDGFRA
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 KDR KIT PDGFRA
8 growth factor binding GO:0019838 8.8 KDR KIT PDGFRA

Sources for Pulmonary Vein Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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