Pulmonary Venoocclusive Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLM025 MIFTS: 47	Pulmonary Venoocclusive Disease Categories: Cardiovascular diseases, Genetic diseases, Immune diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pulmonary Venoocclusive Disease

MalaCards integrated aliases for Pulmonary Venoocclusive Disease:

Name: Pulmonary Venoocclusive Disease ¹² ⁵⁴ ²⁶ ¹³ ¹⁵

Pulmonary Veno-Occlusive Disease ¹² ⁷⁷ ²⁶ ³⁰ ⁵⁶ ⁶ ⁴⁵ ⁴¹ ⁷⁴

Obstructive Disease of the Pulmonary Veins ⁵⁴ ²⁶

Pvod ⁵⁴ ²⁶

Pulmonary Venoocclusive Disease 1, Autosomal Dominant ⁷⁴

Venous Form of Primary Pulmonary Hypertension ²⁶

Isolated Pulmonary Venous Sclerosis ²⁶

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases Respiratory diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5453

MeSH ⁴⁵ D011668

NCIt ⁵¹ C85039

SNOMED-CT ⁶⁹ 89420002

UMLS ⁷⁴ C0034091 C3887658

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Summaries for Pulmonary Venoocclusive Disease

MalaCards based summary : Pulmonary Venoocclusive Disease, also known as pulmonary veno-occlusive disease, is related to pulmonary venoocclusive disease 1, autosomal dominant and pulmonary hypertension, primary, 1, and has symptoms including hemoptysis An important gene associated with Pulmonary Venoocclusive Disease is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways is ALK1 signaling events. The drugs Bevacizumab and Orange have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁷ Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by progressive... more...

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Related Diseases for Pulmonary Venoocclusive Disease

Diseases in the Pulmonary Venoocclusive Disease family:

Pulmonary Venoocclusive Disease 2, Autosomal Recessive

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Diseases related to Pulmonary Venoocclusive Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary venoocclusive disease 1, autosomal dominant	34.1	BMPR2 EIF2AK4
2	pulmonary hypertension, primary, 1	30.3	ACVRL1 BMPR2 KCNK3
3	connective tissue disease	30.1	ACVRL1 BMPR2
4	mixed connective tissue disease	29.9	ACVRL1 BMPR2
5	pulmonary hypertension	28.9	ACVRL1 BMPR2 EIF2AK4 KCNK3 TBX4
6	pulmonary venoocclusive disease 2, autosomal recessive	12.7
7	scleroderma, familial progressive	10.4
8	lymphoma	10.3
9	hypertension, essential	10.2
10	hemolytic anemia	10.2
11	leukemia	10.2
12	thrombosis	10.2
13	lung disease	10.2
14	hypertrophic cardiomyopathy	10.2
15	pontocerebellar hypoplasia	10.1
16	pulmonary embolism	10.1
17	total anomalous pulmonary venous return 1	10.0
18	burkitt lymphoma	10.0
19	felty syndrome	10.0
20	hashimoto thyroiditis	10.0
21	down syndrome	10.0
22	lung cancer	10.0
23	hypoplastic left heart syndrome 1	10.0
24	myeloma, multiple	10.0
25	polycythemia vera	10.0
26	sjogren syndrome	10.0
27	leukemia, acute myeloid	10.0
28	cervical cancer	10.0
29	leukemia, acute lymphoblastic	10.0
30	hematopoietic stem cell transplantation	10.0
31	hypoplastic left heart syndrome	10.0
32	lymphocytic leukemia	10.0
33	pulmonary edema	10.0
34	allergic hypersensitivity disease	10.0
35	mitral valve stenosis	10.0
36	granulomatous angiitis	10.0
37	adenocarcinoma	10.0
38	gastric adenocarcinoma	10.0
39	bone marrow cancer	10.0
40	thyroiditis	10.0
41	mediastinitis	10.0
42	polycythemia	10.0
43	myeloid leukemia	10.0
44	rere-related disorders	10.0
45	sickle cell disease	10.0
46	fibrosing mediastinitis	10.0
47	diffuse alveolar hemorrhage	10.0
48	systemic lupus erythematosus	10.0
49	systemic scleroderma	10.0
50	cardiac tamponade	10.0

Graphical network of the top 20 diseases related to Pulmonary Venoocclusive Disease:

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Symptoms & Phenotypes for Pulmonary Venoocclusive Disease

UMLS symptoms related to Pulmonary Venoocclusive Disease:

hemoptysis

GenomeRNAi Phenotypes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

²⁷ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.58	ACVRL1 BMPR2 TBX4
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.58	ACVRL1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.58	TBX4
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.58	ACVRL1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.58	ACVRL1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-24	9.58	BMPR2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.58	ACVRL1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.58	BMPR2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.58	ACVRL1 TBX4
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-65	9.58	BMPR2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.58	ACVRL1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-80	9.58	BMPR2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.58	ACVRL1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.58	ACVRL1 BMPR2
15	Decreased substrate adherent cell growth	GR00193-A-1	9.56	ACVRL1 APLNR BMPR2
16	Decreased substrate adherent cell growth	GR00193-A-3	9.56	APLNR
17	Decreased substrate adherent cell growth	GR00193-A-4	9.56	ACVRL1 EIF2AK4
18	Decreased human cytomegalovirus (HCMV) strain AD169 replication	GR00248-A	9.33	ACVRL1 BMPR2 EIF2AK4

MGI Mouse Phenotypes related to Pulmonary Venoocclusive Disease:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.8	ACVRL1 APLNR BMPR2 EIF2AK4 KCNK3
2	cardiovascular system	MP:0005385	9.77	ACVRL1 APLNR BMPR2 KCNK3 TBX4
3	homeostasis/metabolism	MP:0005376	9.73	ACVRL1 APLNR BMPR2 EIF2AK4 KCNK3 TBX4
4	embryo	MP:0005380	9.62	ACVRL1 APLNR BMPR2 TBX4
5	muscle	MP:0005369	9.46	ACVRL1 APLNR BMPR2 EIF2AK4
6	nervous system	MP:0003631	9.35	ACVRL1 BMPR2 EIF2AK4 KCNK3 TBX4
7	respiratory system	MP:0005388	8.92	ACVRL1 APLNR BMPR2 KCNK3

Sources

Drugs & Therapeutics for Pulmonary Venoocclusive Disease

Drugs for Pulmonary Venoocclusive Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 1, Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

Orange

Approved

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Angiogenesis Inhibitors

Phase 1, Phase 2

Antineoplastic Agents, Immunological

Phase 1, Phase 2

Angiogenesis Modulating Agents

Phase 1, Phase 2

Protein Kinase Inhibitors

Phase 1, Phase 2

Imatinib Mesylate

Phase 1, Phase 2

220127-57-1

123596

Ambrisentan

Approved, Investigational

177036-94-1

6918493

Synonyms:

(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid

177036-94-1

2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid

2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid

2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid

AC1L53VT

Ambrisentan

Ambrisentan [INN]

Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe

BSF 208075

BSF208075

BSF-208075

C467894

CHEBI:205299

CHEMBL302753

CID197712

Gilead brand of ambrisentan

I06-2077

Letairis

LS-186563

LS-187364

LU 208075

LU208075

LU-208075

MLS001195278

MolPort-002-945-567

NCGC00160662-01

SMR000502713

ST51051295

STK097095

UNII-HW6NV07QEC

Cocaine

Approved, Illicit

50-36-2

446220 5760

Synonyms:

(−)-cocaine

(-)-Cocaine

(-)-Cocaine base

(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate

(R)-Cocaine

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, methyl ester

[1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

1-Cocaine

1i7z

1q72

2beta-Carbomethoxy-3beta-benzoxytropane

2-beta-Carbomethoxy-3-beta-benzoxytropane

2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylic acid benzoic acid (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylate benzoate (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylic acid benzoic acid (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylate benzoate (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylic acid benzoic acid (ester)

2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)

3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)

3-Tropanylbenzoate-2-carboxylic acid methyl ester

50-36-2

53-21-4 (hydrochloride)

610089_ALDRICH

610089_FLUKA

AC-16037

AC1L1EK2

AC1L1L2T

AC1L3U2D

AC1L9JBL

AC-20208

Allococaine

Allopseudococaine

Badrock

Bazooka

b-Cocain

Benzoylethylecgonine

Benzoylmethylecgonine

Bernice

Bernice [Street Name]

Bernies

beta-Cocain

Beta-Cocain

Blast

Blizzard

Blow

Blow [Street Name]

Bouncing Powder

Bump

Burese

C" Carrie

C01416

C8912_SIGMA

Cabello

Candy

Carrie

Caviar

Cecil

Cecil [Street Name]

Charlie

CHEBI:27958

Chicken Scratch

Cholly

CID11779748

CID2826

CID446220

CID5760

COC

Coca

Cocain

Cocaina

cocaine

Cocaine

Cocaine (TN)

Cocaine (USP)

Cocaine [BAN]

Cocaine free base

Cocaine Free Base

Cocaine HCL

Cocaine hydrochloride

Cocaine solution

Cocaine-M

cocainum

Cocainum

Cocktail

Coke

Cola

Corine

CPD-9776

Crack

Crack cocaine

D00110

Dama blanca

Dama Blanca

DB00907

DEA No. 9041

Delcaine

Depsococaine

Dextrocaine

DivK1c_000975

d-Pseudococaine

D-pseudococaine

Dust

Ecgonine methyl ester benzoate

Ecgonine methyl ester benzoate solution

Ecgonine, methyl ester, benzoate (ester)

EINECS 200-032-7

Eritroxilina

Erytroxylin

Flake

Flake [Street Name]

Flex

Florida Snow

Foo Foo

Freeze

Girl

Girl [Street Name]

Gold dust

Gold Dust

Gold dust [Street Name]

Goofball

Green gold

Green Gold

G-Rock

Happy dust

Happy Dust

Happy dust [Street Name]

Happy powder

Happy Powder

Happy trails

Happy Trails

HCL, Cocaine

Heaven

Hell

HSDB 6469

Hydrochloride, cocaine

IDI1_000975

Isocaine

Isococain

Isococaine

Jam

KBio1_000975

Kibbles n' Bits

Kibbles N' Bits

Kokain

Kokan

Kokayeen

L000836

Lady

Lady [Street Name]

l-Cocain

L-Cocain

L-Cocaine

Leaf

LS-157759

methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid

Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester)

Methyl benzoylecgonine

Methyl Benzoylecgonine

MLS002320697

MolPort-002-535-520

MolPort-003-937-722

Moonrocks

NCGC00159467-02

nchembio.284-comp4

Neurocaine

NINDS_000975

Nose candy

Pimp's drug

Pimp's Drug

Prime Time

Pseudoallococaine

Pseudococaine

Rock

Rock [Street Name]

Sleighride

SMR001338843

Snort

Snow

Snow (birds)

Star dust

Star Dust

Star-spangled powder

Star-Spangled Powder

STOCK1N-68258

Sugar

Sweet Stuff

Toke

Toot

Toot [Street Name]

Trails

UNII-I5Y540LHVR

White girl or lady

Yeyo

Zip

β-cocain

Methamphetamine

Approved, Illicit

537-46-2

10836

Synonyms:

(+ )-methylamphetamine

(+ )-Methylamphetamine

(+)-(s)-deoxyephedrine

(+)-(S)-Deoxyephedrine

(+)-(S)-N-a-Dimethylphenethylamine

(+)-(s)-n-alpha-dimethylphenethylamine

(+)-(S)-N-alpha-Dimethylphenethylamine

(+)-(S)-N-α-dimethylphenethylamine

(+)-2-(N-methylamino)-1-Phenylpropane

(+)-2-(N-Methylamino)-1-phenylpropane

(+)-methamphetamine

(+)-Methamphetamine

(+)-methylamphetamine

(+)-Methylamphetamine

(+)-n,alpha-dimethyl-beta-phenylethylamine

(+)-N,alpha-Dimethyl-beta-phenylethylamine

(+)-n,alpha-dimethylphenethylamine

(+)-N,alpha-Dimethylphenethylamine

(+)-n-methylamphetamine

(+)-N-Methylamphetamine

(2S)-N-methyl-1-phenylpropan-2-amine

(2S)-N-Methyl-1-phenylpropan-2-amine

(AlphaS)-N,a-dimethylbenzeneethanamine

(alphaS)-N,alpha-dimethylbenzeneethanamine

(AlphaS)-N,alpha-dimethylbenzeneethanamine

(AlphaS)-N,α-dimethylbenzeneethanamine

(s)-(+)-deoxyephedrine

(S)-(+)-Deoxyephedrine

(s)-(+)-methamphetamine

(S)-(+)-Methamphetamine

(s)-(+)-n,alpha,dimethylphenethylamine

(S)-(+)-N,alpha,dimethylphenethylamine

(S)-(+)-N,alpha,Dimethylphenethylamine

(s)-methamphetamine

(S)-Methamphetamine

(s)-methylamphetamine

(S)-Methylamphetamine

(S)-N,a-Dimethylbenzeneethanamine

(s)-n,alpha-dimethylbenzeneethanamine

(S)-N,alpha-Dimethylbenzeneethanamine

(s)-n,alpha-dimethylbenzeneethanoamine

(S)-N,alpha-Dimethylbenzeneethanoamine

(S)-N,α-dimethylbenzeneethanamine

(αS)-N,α-dimethylbenzeneethanamine

139-47-9

14611-50-8

1690-86-4

1-Phenyl-2-methylamino-propan

1-Phenyl-2-methylamino-propan [German]

1-Phenyl-2-methylaminopropane

2S-(+)-Methamphetamine

45952-89-4

537-46-2

Abbott brand OF methamphetamine hydrochloride

AC1L1W1Z

AC1Q4SVR

B40

Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI)

Benzeneethanamine, N,alpha-dimethyl-, (S)- (9CI)

C07164

C10H15N

CHEBI:6809

CHEMBL1201201

CID10836

Crank

Crank [Street Name]

Crystal Meth

Crystal Meth [Street Name]

d-(S)-Methamphetamine

D-(s)-methamphetamine

D-(S)-Methamphetamine

D08187

D-1-Phenyl-2-methylaminopropan

d-1-Phenyl-2-methylaminopropan [German]

d-1-phenyl-2-methylaminopropane

D-1-Phenyl-2-methylaminopropane

DB01577

d-deoxyephedrine

d-Deoxyephedrine

D-deoxyephedrine

D-Deoxyephedrine

d-desoxyephedrine

d-Desoxyephedrine

D-desoxyephedrine

D-Desoxyephedrine

DEA No. 1105

Deoxyephedrine

desohyephedrine

Desoxyephedrine

Desoxyephedrine hydrochloride

Desoxyn

Desyphed

Desyphed hydrochloride

Dextromethamphetamine

d-Methamphetamine

D-methamphetamine

D-Methamphetamine

d-Methylamphetamine

D-methylamphetamine

D-Methylamphetamine

d-N,.alpha.-Dimethylphenethylamine

D-n,alpha-dimethylphenethylamine

D-N,alpha-dimethylphenethylamine

D-N,alpha-Dimethylphenethylamine

d-N-methylamphetamine

d-N-Methylamphetamine

D-n-methylamphetamine

D-N-Methylamphetamine

d-phenylisopropylmethylamine

d-Phenylisopropylmethylamine

D-phenylisopropylmethylamine

D-Phenylisopropylmethylamine

EINECS 208-668-7

HSDB 3359

Hydrochloride, methamphetamine

Ice

ICE [Street Name]

Langly brand OF methamphetamine hydrochloride

L-methamphetamine

L-Methamphetamine

LS-103331

Madrine

Metamfetamina

Metamfetamina [inn-spanish]

Metamfetamina [INN-Spanish]

Metamfetamine

Métamfétamine

Metamfetamine (INN)

Metamfetamine [INN]

Metamfetamine-m

Metamfetaminum

Metamfetaminum [inn-latin]

Metamfetaminum [INN-Latin]

Metamfetaminum [Latin]

Metamphetamine

Metanfetamina

Metanfetamina [inn-spanish]

Metanfetamina [INN-Spanish]

Metanfetamina [Spanish]

Meth

Meth (Street Name)

Methamphetamine

METHAMPHETAMINE

Methamphetamine hydrochloride

Methamphetamine, its salts, isomers, and salts of its isomers

Methamphetaminum

Methamphetaminum [inn-latin]

Methamphetaminum [INN-Latin]

Methamphetaminum [JP]

Methyl-.beta.-phenylisopropylamine

Methylamphetamine

Methyl-beta-phenylisopropylamine

Methyl-b-phenylisopropylamine

methyl-β-phenylisopropylamine

Methyl-β-phenylisopropylamine

MolPort-001-794-405

N Methylamphetamine

N-Methyl-1-phenyl-2-propanamine

N-methylamphetamine

N-Methylamphetamine

N-Methyl-beta-phenylisopropylamin

N-methyl-beta-phenylisopropylamin [german]

N-Methyl-beta-phenylisopropylamin [German]

N-methyl-beta-phenylisopropylamine

N-Methyl-beta-phenylisopropylamine

Norodin

NSC 25115

NSC25115

PDSP1_001404

PDSP1_001405

PDSP2_001388

PDSP2_001389

Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI)

S-(+)-methamphetamine

S-(+)-Methamphetamine

Speed

Speed [Street Name]

Stimulex

UNII-44RAL3456C

WLN: 1MY1&1R -D

Bosentan

Approved, Investigational

147536-97-8

104865

Synonyms:

147536-97-8

174227-18-0

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulphornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide

4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

AC-148

AC1L2XN2

Actelion

Bosentan

bosentán

Bosentan (INN)

Bosentan [USAN:INN:BAN]

bosentan anhydrous

Bosentan anhydrous

Bosentan hydrate

Bosentan monohydrate

bosentanum

Bosentanum

C27H29N5O6S

CHEBI:51450

CHEMBL957

CID104865

D07538

DB00559

EN002863

HMS2090N14

I06-1873

KS-5062

L001086

LS-31532

MolPort-003-845-300

NCGC00167440-01

PDSP1_001731

PDSP2_001714

p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulphonamide

p-tert-Butyl-N-[6-(2-hydroxyethoxy)

Ro 47-0203

Ro 47-0203/039

Ro-47-0203

Ro-47-0203/029

Ro-47-0203/039

TL8001039

Tracleer

UNII-XUL93R30K2

Sodium Citrate

Approved, Investigational

68-04-2

Synonyms:

Anhydrous sodium citrate

Anhydrous trisodium citrate

Citric acid, trisodium salt

Natrii citras

Natrocitral

Sodium citrate anhydrous

Sodium citrate, anhydrous

Sodium citrate,anhydrous

trisodium citrate anhydrous

Trisodium citrate, anhydrous

Trisodium-citrate

Nitric Oxide

Approved

Not Applicable

10102-43-9

145068

Synonyms:

(.)NO

(no)(.)

(NO)(.)

[no]

[NO]

10102-43-9

14332-28-6

295566_ALDRICH

51005-20-0

51005-21-1

53851-19-7

90452-29-2

AC1L1ADQ

AC1L3QHF

AC1Q6QZ0

AR-1K7463

Bioxyde d'azote

Bioxyde d'azote [French]

C00533

CCRIS 4319

CHEMBL1200689

CHEMBL1234765

CID145068

CID945

D00074

D009569

DB00435

EDRF

EINECS 233-271-0

Endogenous nitrate vasodilator

Endogenous Nitrate Vasodilator

Endothelium-derived nitric oxide

Endothelium-Derived Nitric Oxide

endothelium-derived relaxing factor

Endothelium-derived relaxing factor

HNO

HSDB 1246

INOmax

INOmax (TN)

LS-192158

LS-7547

MolPort-003-929-452

Mononitrogen monoxide

Monoxide, mononitrogen

Monoxide, Mononitrogen

Monoxide, nitrogen

Monoxide, Nitrogen

monoxido de nitrogeno

monoxido De nitrogeno

Monóxido de nitrógeno

monoxyde d'azote

Monoxyde d'azote

Nitrate vasodilator, endogenous

Nitrate Vasodilator, Endogenous

nitric oxide

Nitric oxide

Nitric oxide (JAN)

Nitric oxide 10% by volume or more

Nitric oxide trimer

Nitric oxide, compressed [UN1660] [Poison gas]

Nitric oxide, endothelium derived

Nitric Oxide, Endothelium Derived

Nitric oxide, endothelium-derived

Nitric Oxide, Endothelium-Derived

NITRIC-OXIDE

nitrogen monooxide

Nitrogen monooxide

nitrogen monoxide

Nitrogen monoxide

Nitrogen oxide

Nitrogen oxide (NO)

Nitrogen protoxide

nitrosyl

Nitrosyl

Nitrosyl hydride

Nitrosyl hydride ((NO)H)

Nitrosyl radical

Nitroxide radical

Nitroxyl

no(.)

NO(.)

OHM 11771

Oxide, nitric

Oxide, Nitric

oxido de nitrogeno(II)

oxido De nitrogeno(II)

óxido de nitrógeno(II)

oxido nitrico

oxido Nitrico

óxido nítrico

oxidonitrogen(.)

oxoazanyl

oxyde azotique

Oxyde azotique

Oxyde nitrique

Oxyde nitrique [French]

RCRA waste no. P076

Stickmonoxyd

Stickmonoxyd [German]

Stickstoff(II)-oxid

Stickstoffmonoxid

UN 1660

UN1660

UNII-31C4KY9ESH

Vasodilator, endogenous nitrate

Vasodilator, Endogenous Nitrate

Carbon monoxide

Approved, Investigational

Not Applicable

630-08-0

281

Citric Acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

ácido cítrico

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citretten

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric Acid, Anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

uro-Trainer

glutamine

Not Applicable

Endothelin Receptor Antagonists

Antihypertensive Agents

Tryptophan

Phosphodiesterase Inhibitors

Phosphodiesterase 5 Inhibitors

Citrate

Sildenafil Citrate

171599-83-0

Vasodilator Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis	Completed	NCT00891527	Phase 1, Phase 2	Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
2	Effects on Glutamine on the Outcome of Allogeneic Bone Marrow Transplant Recipients	Unknown status	NCT00563498	Not Applicable	Glutamine
3	Pharmacogenomics in Pulmonary Arterial Hypertension	Unknown status	NCT00593905		Sitaxsentan;Bosentan, Ambrisentan
4	Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)	Completed	NCT00666198		SILDENAFIL
5	Registration Study for Rare Type of Pulmonary Hypertension	Recruiting	NCT03169010
6	Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers	Not yet recruiting	NCT03902353	Not Applicable

Search NIH Clinical Center for Pulmonary Venoocclusive Disease

Cochrane evidence based reviews: pulmonary veno-occlusive disease

Sources

Genetic Tests for Pulmonary Venoocclusive Disease

Genetic tests related to Pulmonary Venoocclusive Disease:

#	Genetic test	Affiliating Genes
1	Pulmonary Veno-Occlusive Disease ³⁰	BMPR2

Sources

Anatomical Context for Pulmonary Venoocclusive Disease

MalaCards organs/tissues related to Pulmonary Venoocclusive Disease:

⁴²

Heart, Bone, Lung, Bone Marrow, Myeloid, Thyroid, Endothelial

Sources

Publications for Pulmonary Venoocclusive Disease

Articles related to Pulmonary Venoocclusive Disease:

(show top 50) (show all 235)

#	Title	Authors	Year
1	Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension. ( 31010327 )	Hajouli S...Memoli JSW	2019
2	Pulmonary veno-occlusive disease is highly prevalent in scleroderma patients undergoing lung transplantation. ( 30775371 )	Gupta S...George MP	2019
3	Extracorporeal Membrane Oxygenation Support During Pregnancy in Pulmonary Veno-occlusive Disease. ( 29428338 )	Ortiz-Bautista C...Escribano-Sub?as P	2019
4	Use of vasodilators for the treatment of pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A systematic review. ( 30473253 )	Ogawa A...Tatsumi K	2019
5	Clinical features of canine pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 30499214 )	Reinero CR...Williams K	2019
6	Pulmonary Veno-occlusive Disease: A Surgical Lung Biopsy-proven and Autopsied Case Radiologically Mimicking Hypersensitivity Pneumonitis at the Time of a Transbronchial Lung Biopsy. ( 30568112 )	Minomo S...Inoue Y	2019
7	Comprehensive three-dimensional morphology of neoangiogenesis in pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 30697960 )	Neubert L...Jonigk D	2019
8	Beneficial Effects of Imatinib in a Patient with Suspected Pulmonary Veno-Occlusive Disease. ( 30700638 )	Sato H...Shimokawa H	2019
9	Understanding Hepatic and Pulmonary Veno-Occlusive Disease: Similarities and Differences. ( 30926335 )	G?nther S...Montani D	2019
10	Pulmonary tumor thrombotic microangiopathy and pulmonary veno-occlusive disease in a woman with cervical cancer treated with cediranib and durvalumab. ( 29996818 )	Suffredini DA...Solomon MA	2018
11	Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog. ( 30518401 )	den Toom ML...Szatm?ri V	2018
12	Variable Expressivity of a Founder Mutation in the EIF2AK4 Gene in Hereditary Pulmonary Veno-occlusive Disease and Its Impact on Survival. ( 28697925 )	Navas Tejedor P...Escribano Sub?as P	2018
13	Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. ( 28958195 )	Zinter MS...Fineman JR	2018
14	Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease. ( 29108819 )	Nossent EJ...Dorfm?ller P	2018
15	Clinical prediction score for identifying patients with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. ( 29548663 )	Ogawa A...Matsubara H	2018
16	Pulmonary veno-occlusive disease: pathogenesis, risk factors, clinical features and diagnostic algorithm - state of the art. ( 29960280 )	Szturmowicz M...Ku? J	2018
17	Lung transplantation as a viable option of treatment for pulmonary veno-occlusive disease. ( 30378654 )	Ochman M...Zembala M	2018
18	Rapidly progressive pulmonary veno-occlusive disease in an infant with Down syndrome. ( 28782495 )	Muneuchi J...Shimizu D	2017
19	Pulmonary veno-occlusive disease as an occupational lung disease. ( 28463181 )	Montani D...Humbert M	2017
20	Pulmonary Hypertension Associated with Pulmonary Veno-occlusive Disease in Patients with Polycythemia Vera. ( 28824072 )	Tachibana T...Nakajima H	2017
21	Pulmonary veno-occlusive disease: An important consideration in patients with pulmonary hypertension. ( 29229098 )	Balko R...Test V	2017
22	Sudden Death in a Patient with Pulmonary Veno-occlusive Disease (PVOD) and Severe Pulmonary Hypertension. ( 28768975 )	Saito M...Ohta K	2017
23	Pulmonary hypertension secondary to pulmonary veno-occlusive disease complicated by right heart failure, hypotension and acute kidney injury. ( 27872804 )	Golzy N...Hage A	2017
24	Prognostic significance of computed tomography criteria for pulmonary veno-occlusive disease in systemic sclerosis-pulmonary arterial hypertension. ( 29029203 )	Connolly MJ...Coghlan JG	2017
25	The First Experience of Pulmonary Veno-occlusive Disease Treatment With Macitentan and Sildenafil. ( 27840150 )	Chamorro Fern?ndez CI...Quezada Loaiza CA	2017
26	Pulmonary veno-occlusive disease: Two children with gradual disease progression. ( 28070482 )	Day RW...Alashari M	2017
27	Pulmonary veno-occlusive disease: characterising a rare but important disease. ( 28087361 )	Hadinnapola C...Morrell NW	2017
28	Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study. ( 28087362 )	Montani D...Humbert M	2017
29	Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 28118962 )	Ortiz-Bautista C...Escribano-Sub?as P	2017
30	Myocardial injury in severe heritable pulmonary veno-occlusive disease. ( 28320632 )	Ortiz-Bautista C...Escribano-Sub?as P	2017
31	Efficacy and safety of long-term imatinib therapy for patients with pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 28947033 )	Ogawa A...Matsubara H	2017
32	Lung transplantation for mitomycin-induced pulmonary veno-occlusive disease. ( 29129416 )	Savale L...Montani D	2017
33	Pulmonary Veno-Occlusive Disease: Welcome to the PAHty (Bostonian for Party). ( 29158214 )	Miller DP...Farber HW	2017
34	Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs: Striking Similarities to the Human Condition. ( 27298303 )	Stenmark KR...Tuder RM	2016
35	Pulmonary Veno-Occlusive Disease: A Newly Recognized Cause of Severe Pulmonary Hypertension in Dogs. ( 26926086 )	Williams K...Jutkowitz A	2016
36	Small Sample Lung Biopsy Findings in Patients With Clinicoradiologic Suspicion of Pulmonary Venoocclusive Disease-Pulmonary Capillary Hemangiomatosis. ( 27623416 )	Bal SK...Christopher DJ	2016
37	Reactive Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-Occlusive Disease in a Patient with Repaired Scimitar Syndrome. ( 27069695 )	G?ttinger E...Huber LC	2016
38	Founder mutation C.3344C>t(p.Pro1115Leu) in the EIF2KA4 gene in iberian romani patients with pulmonary veno-occlusive disease: A warning for our daily practice. ( 26915523 )	Navas P...Escribano Sub?as P	2016
39	Pulmonary veno-occlusive disease. ( 27009171 )	Montani D...Humbert M	2016
40	Letter by Belge et al Regarding Article, "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models". ( 27045135 )	Belge C...Delcroix M	2016
41	Response to Letter Regarding Article, "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Model". ( 27045136 )	Perros F...Montani D	2016
42	Favorable response to an endothelin receptor antagonist in mitomycin-induced pulmonary veno-occlusive disease with pulmonary capillary hemangiomatosis. ( 27045880 )	Koyama M...Miura T	2016
43	Scintigraphy Leading to the Misdiagnosis of Chronic Thromboembolic Disease in a Patient With Pulmonary Veno-Occlusive Disease. ( 27142608 )	Balke L...Bewig B	2016
44	Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-occlusive Disease. ( 27514598 )	Chaisson NF...Elliott CG	2016
45	EIF2AK4 mutation in pulmonary veno-occlusive disease: A case report and review of the literature. ( 27684876 )	Liang L...Zhang R	2016
46	Pulmonary veno-occlusive disease: a rare cause of pulmonary hypertension in systemic sclerosis. Case presentation and review of the literature . ( 26402988 )	Daraban AM...Jurcu? R	2015
47	Pulmonary veno-occlusive disease as a cause of pulmonary arterial hypertension. ( 26130886 )	Porres-Aguilar M...Abbas A	2015
48	Pulmonary veno-occlusive disease: a rare cause of pulmonary hypertension. ( 25528660 )	Yahagi K...Virmani R	2015
49	Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models. ( 26130118 )	Perros F...Montani D	2015
50	Letter by Papangeli et al Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". ( 26169651 )	Papangeli I...Chun HJ	2015

Sources

Genes for Pulmonary Venoocclusive Disease

Genes related to Pulmonary Venoocclusive Disease (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	145.12	Genetic Tests ³⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
2	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	46.64	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
3	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	16.35	DISEASES inferred ¹⁵
4	KCNK3	Potassium Two Pore Domain Channel Subfamily K Member 3	Protein Coding	16.1	DISEASES inferred ¹⁵
5	APLNR	Apelin Receptor	Protein Coding	15.71	DISEASES inferred ¹⁵
6	TBX4	T-Box 4	Protein Coding	15.27	DISEASES inferred ¹⁵

Sources

Variations for Pulmonary Venoocclusive Disease

Sources

Expression for Pulmonary Venoocclusive Disease

Search GEO for disease gene expression data for Pulmonary Venoocclusive Disease.

Sources

Pathways for Pulmonary Venoocclusive Disease

Pathways related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ALK1 signaling events ¹ Show member pathways ALK1 pathway ¹	10.05	ACVRL1 BMPR2

Sources

GO Terms for Pulmonary Venoocclusive Disease

Cellular components related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	8.92	ACVRL1 APLNR BMPR2 KCNK3

Biological processes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.77	ACVRL1 BMPR2 EIF2AK4
2	protein phosphorylation	GO:0006468	9.75	ACVRL1 BMPR2 EIF2AK4
3	angiogenesis	GO:0001525	9.63	ACVRL1 APLNR TBX4
4	negative regulation of cell growth	GO:0030308	9.58	ACVRL1 BMPR2
5	transforming growth factor beta receptor signaling pathway	GO:0007179	9.57	ACVRL1 BMPR2
6	BMP signaling pathway	GO:0030509	9.56	ACVRL1 BMPR2
7	positive regulation of endothelial cell proliferation	GO:0001938	9.55	ACVRL1 BMPR2
8	pattern specification process	GO:0007389	9.54	ACVRL1 BMPR2
9	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	9.52	ACVRL1 BMPR2
10	cellular response to BMP stimulus	GO:0071773	9.51	ACVRL1 BMPR2
11	positive regulation of BMP signaling pathway	GO:0030513	9.49	ACVRL1 BMPR2
12	blood vessel remodeling	GO:0001974	9.48	ACVRL1 BMPR2
13	transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	9.43	ACVRL1 BMPR2
14	activin receptor signaling pathway	GO:0032924	9.4	ACVRL1 BMPR2
15	negative regulation of DNA biosynthetic process	GO:2000279	9.37	ACVRL1 BMPR2
16	lymphangiogenesis	GO:0001946	9.32	ACVRL1 BMPR2
17	artery development	GO:0060840	9.26	ACVRL1 BMPR2
18	retina vasculature development in camera-type eye	GO:0061298	9.16	ACVRL1 BMPR2
19	lymphatic endothelial cell differentiation	GO:0060836	8.96	ACVRL1 BMPR2
20	venous blood vessel development	GO:0060841	8.62	ACVRL1 BMPR2

Molecular functions related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.61	ACVRL1 BMPR2 EIF2AK4
2	protein kinase activity	GO:0004672	9.58	ACVRL1 BMPR2 EIF2AK4
3	protein serine/threonine kinase activity	GO:0004674	9.54	ACVRL1 BMPR2 EIF2AK4
4	SMAD binding	GO:0046332	9.32	ACVRL1 BMPR2
5	growth factor binding	GO:0019838	9.26	ACVRL1 BMPR2
6	transforming growth factor beta-activated receptor activity	GO:0005024	9.16	ACVRL1 BMPR2
7	transmembrane receptor protein serine/threonine kinase activity	GO:0004675	8.96	ACVRL1 BMPR2
8	BMP receptor activity	GO:0098821	8.62	ACVRL1 BMPR2

Sources

Sources for Pulmonary Venoocclusive Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia