Pulmonary Venoocclusive Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PVOD MCID: PLM025 MIFTS: 46	Pulmonary Venoocclusive Disease (PVOD) Categories: Cardiovascular diseases, Genetic diseases, Immune diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pulmonary Venoocclusive Disease

MalaCards integrated aliases for Pulmonary Venoocclusive Disease:

Name: Pulmonary Venoocclusive Disease ¹² ⁵³ ²⁵ ¹³ ¹⁵

Pulmonary Veno-Occlusive Disease ¹² ⁷⁶ ²⁵ ²⁹ ⁵⁵ ⁶ ⁴⁴ ⁴⁰ ⁷³

Obstructive Disease of the Pulmonary Veins ⁵³ ²⁵

Pvod ⁵³ ²⁵

Pulmonary Venoocclusive Disease 1, Autosomal Dominant ⁷³

Venous Form of Primary Pulmonary Hypertension ²⁵

Isolated Pulmonary Venous Sclerosis ²⁵

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases Respiratory diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5453

MeSH ⁴⁴ D011668

NCIt ⁵⁰ C85039

SNOMED-CT ⁶⁸ 89420002

UMLS ⁷³ C0034091 C3887658

Sources

Summaries for Pulmonary Venoocclusive Disease

MalaCards based summary : Pulmonary Venoocclusive Disease, also known as pulmonary veno-occlusive disease, is related to pulmonary venoocclusive disease 1, autosomal dominant and pulmonary hypertension, primary, 1, and has symptoms including hemoptysis An important gene associated with Pulmonary Venoocclusive Disease is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways is ALK1 signaling events. The drugs Bevacizumab and Orange have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : ⁷⁶ Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by progressive... more...

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Related Diseases for Pulmonary Venoocclusive Disease

Diseases in the Pulmonary Venoocclusive Disease family:

Pulmonary Venoocclusive Disease 2, Autosomal Recessive

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Diseases related to Pulmonary Venoocclusive Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary venoocclusive disease 1, autosomal dominant	34.0	BMPR2 EIF2AK4
2	pulmonary hypertension, primary, 1	30.4	ACVRL1 BMPR2 KCNK3
3	connective tissue disease	30.1	ACVRL1 BMPR2
4	mixed connective tissue disease	30.0	ACVRL1 BMPR2
5	pulmonary hypertension	29.4	ACVRL1 BMPR2 EIF2AK4 KCNK3 TBX4
6	pulmonary venoocclusive disease 2, autosomal recessive	12.6
7	scleroderma, familial progressive	10.4
8	lymphoma	10.3
9	hemolytic anemia	10.2
10	thrombosis	10.2
11	lung disease	10.2
12	hypertrophic cardiomyopathy	10.2
13	total anomalous pulmonary venous return 1	10.0
14	down syndrome	10.0
15	lung cancer	10.0
16	hypoplastic left heart syndrome 1	10.0
17	myeloma, multiple	10.0
18	neuroblastoma	10.0
19	polycythemia vera	10.0
20	leukemia, acute myeloid	10.0
21	cervical cancer	10.0
22	leukemia, acute lymphoblastic	10.0
23	hematopoietic stem cell transplantation	10.0
24	hypoplastic left heart syndrome	10.0
25	leukemia	10.0
26	lymphocytic leukemia	10.0
27	pulmonary edema	10.0
28	granulomatous angiitis	10.0
29	adenocarcinoma	10.0
30	gastric adenocarcinoma	10.0
31	thyroiditis	10.0
32	mediastinitis	10.0
33	polycythemia	10.0
34	myeloid leukemia	10.0
35	viral infectious disease	10.0
36	sickle cell disease	10.0
37	fibrosing mediastinitis	10.0
38	diffuse alveolar hemorrhage	10.0
39	chronic pulmonary heart disease	10.0	ACVRL1 BMPR2
40	systemic lupus erythematosus	10.0
41	lupus erythematosus	10.0
42	telangiectasis	10.0	ACVRL1 BMPR2
43	hepatopulmonary syndrome	10.0	ACVRL1 BMPR2
44	arteriovenous malformation	10.0	ACVRL1 BMPR2
45	arteries, anomalies of	9.8	ACVRL1 BMPR2
46	heritable pulmonary arterial hypertension	9.4	ACVRL1 BMPR2 EIF2AK4 KCNK3 TBX4

Graphical network of the top 20 diseases related to Pulmonary Venoocclusive Disease:

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Symptoms & Phenotypes for Pulmonary Venoocclusive Disease

UMLS symptoms related to Pulmonary Venoocclusive Disease:

hemoptysis

GenomeRNAi Phenotypes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-1	9.56	ACVRL1 APLNR BMPR2
2	Decreased substrate adherent cell growth	GR00193-A-3	9.56	APLNR
3	Decreased substrate adherent cell growth	GR00193-A-4	9.56	ACVRL1 EIF2AK4
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.55	ACVRL1 BMPR2 TBX4
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.55	ACVRL1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.55	TBX4
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.55	ACVRL1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.55	ACVRL1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-24	9.55	BMPR2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.55	ACVRL1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.55	BMPR2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.55	ACVRL1 TBX4
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.55	ACVRL1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-80	9.55	BMPR2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.55	ACVRL1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.55	ACVRL1 BMPR2
17	Decreased human cytomegalovirus (HCMV) strain AD169 replication	GR00248-A	9.33	ACVRL1 BMPR2 EIF2AK4

MGI Mouse Phenotypes related to Pulmonary Venoocclusive Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.8	ACVRL1 APLNR BMPR2 EIF2AK4 KCNK3
2	cardiovascular system	MP:0005385	9.77	ACVRL1 APLNR BMPR2 KCNK3 TBX4
3	homeostasis/metabolism	MP:0005376	9.73	ACVRL1 APLNR BMPR2 EIF2AK4 KCNK3 TBX4
4	embryo	MP:0005380	9.62	ACVRL1 APLNR BMPR2 TBX4
5	muscle	MP:0005369	9.46	ACVRL1 APLNR BMPR2 EIF2AK4
6	nervous system	MP:0003631	9.35	ACVRL1 BMPR2 EIF2AK4 KCNK3 TBX4
7	respiratory system	MP:0005388	8.92	ACVRL1 APLNR BMPR2 KCNK3

Sources

Drugs & Therapeutics for Pulmonary Venoocclusive Disease

Drugs for Pulmonary Venoocclusive Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 1, Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

Orange

Approved

Phase 1, Phase 2

Protein Kinase Inhibitors

Phase 1, Phase 2

Angiogenesis Modulating Agents

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Imatinib Mesylate

Phase 1, Phase 2

220127-57-1

123596

Angiogenesis Inhibitors

Phase 1, Phase 2

Cocaine

Approved, Illicit

50-36-2

5760 446220

Synonyms:

(−)-cocaine

(-)-Cocaine

(-)-Cocaine base

(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate

(R)-Cocaine

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, methyl ester

[1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

1-Cocaine

1i7z

1q72

2beta-Carbomethoxy-3beta-benzoxytropane

2-beta-Carbomethoxy-3-beta-benzoxytropane

2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylic acid benzoic acid (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylate benzoate (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylic acid benzoic acid (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylate benzoate (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylic acid benzoic acid (ester)

2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)

3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)

3-Tropanylbenzoate-2-carboxylic acid methyl ester

50-36-2

53-21-4 (hydrochloride)

610089_ALDRICH

610089_FLUKA

AC-16037

AC1L1EK2

AC1L1L2T

AC1L3U2D

AC1L9JBL

AC-20208

Allococaine

Allopseudococaine

Badrock

Bazooka

b-Cocain

Benzoylethylecgonine

Benzoylmethylecgonine

Bernice

Bernice [Street Name]

Bernies

beta-Cocain

Beta-Cocain

Blast

Blizzard

Blow

Blow [Street Name]

Bouncing Powder

Bump

Burese

C" Carrie

C01416

C8912_SIGMA

Cabello

Candy

Carrie

Caviar

Cecil

Cecil [Street Name]

Charlie

CHEBI:27958

Chicken Scratch

Cholly

CID11779748

CID2826

CID446220

CID5760

COC

Coca

Cocain

Cocaina

cocaine

Cocaine

Cocaine (TN)

Cocaine (USP)

Cocaine [BAN]

Cocaine free base

Cocaine Free Base

Cocaine HCL

Cocaine hydrochloride

Cocaine solution

Cocaine-M

cocainum

Cocainum

Cocktail

Coke

Cola

Corine

CPD-9776

Crack

Crack cocaine

D00110

Dama blanca

Dama Blanca

DB00907

DEA No. 9041

Delcaine

Depsococaine

Dextrocaine

DivK1c_000975

d-Pseudococaine

D-pseudococaine

Dust

Ecgonine methyl ester benzoate

Ecgonine methyl ester benzoate solution

Ecgonine, methyl ester, benzoate (ester)

EINECS 200-032-7

Eritroxilina

Erytroxylin

Flake

Flake [Street Name]

Flex

Florida Snow

Foo Foo

Freeze

Girl

Girl [Street Name]

Gold dust

Gold Dust

Gold dust [Street Name]

Goofball

Green gold

Green Gold

G-Rock

Happy dust

Happy Dust

Happy dust [Street Name]

Happy powder

Happy Powder

Happy trails

Happy Trails

HCL, Cocaine

Heaven

Hell

HSDB 6469

Hydrochloride, cocaine

IDI1_000975

Isocaine

Isococain

Isococaine

Jam

KBio1_000975

Kibbles n' Bits

Kibbles N' Bits

Kokain

Kokan

Kokayeen

L000836

Lady

Lady [Street Name]

l-Cocain

L-Cocain

L-Cocaine

Leaf

LS-157759

methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid

Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester)

Methyl benzoylecgonine

Methyl Benzoylecgonine

MLS002320697

MolPort-002-535-520

MolPort-003-937-722

Moonrocks

NCGC00159467-02

nchembio.284-comp4

Neurocaine

NINDS_000975

Nose candy

Pimp's drug

Pimp's Drug

Prime Time

Pseudoallococaine

Pseudococaine

Rock

Rock [Street Name]

Sleighride

SMR001338843

Snort

Snow

Snow (birds)

Star dust

Star Dust

Star-spangled powder

Star-Spangled Powder

STOCK1N-68258

Sugar

Sweet Stuff

Toke

Toot

Toot [Street Name]

Trails

UNII-I5Y540LHVR

White girl or lady

Yeyo

Zip

β-cocain

Ambrisentan

Approved, Investigational

177036-94-1

6918493

Synonyms:

(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid

177036-94-1

2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid

2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid

2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid

AC1L53VT

Ambrisentan

Ambrisentan [INN]

Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe

BSF 208075

BSF208075

BSF-208075

C467894

CHEBI:205299

CHEMBL302753

CID197712

Gilead brand of ambrisentan

I06-2077

Letairis

LS-186563

LS-187364

LU 208075

LU208075

LU-208075

MLS001195278

MolPort-002-945-567

NCGC00160662-01

SMR000502713

ST51051295

STK097095

UNII-HW6NV07QEC

Bosentan

Approved, Investigational

147536-97-8

104865

Synonyms:

147536-97-8

174227-18-0

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulphornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide

4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

AC-148

AC1L2XN2

Actelion

bosentan

Bosentan

bosentán

Bosentan (INN)

Bosentan [USAN:INN:BAN]

bosentan anhydrous

Bosentan anhydrous

Bosentan hydrate

Bosentan monohydrate

bosentanum

Bosentanum

C27H29N5O6S

CHEBI:51450

CHEMBL957

CID104865

D07538

DB00559

EN002863

HMS2090N14

I06-1873

KS-5062

L001086

LS-31532

MolPort-003-845-300

NCGC00167440-01

PDSP1_001731

PDSP2_001714

p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulphonamide

p-tert-Butyl-N-[6-(2-hydroxyethoxy)

Ro 47-0203

Ro 47-0203/039

Ro-47-0203

Ro-47-0203/029

Ro-47-0203/039

TL8001039

Tracleer

UNII-XUL93R30K2

Methamphetamine

Approved, Illicit

537-46-2

10836

Synonyms:

(+ )-methylamphetamine

(+ )-Methylamphetamine

(+)-(s)-deoxyephedrine

(+)-(S)-Deoxyephedrine

(+)-(S)-N-a-Dimethylphenethylamine

(+)-(s)-n-alpha-dimethylphenethylamine

(+)-(S)-N-alpha-Dimethylphenethylamine

(+)-(S)-N-α-dimethylphenethylamine

(+)-2-(N-methylamino)-1-Phenylpropane

(+)-2-(N-Methylamino)-1-phenylpropane

(+)-methamphetamine

(+)-Methamphetamine

(+)-methylamphetamine

(+)-Methylamphetamine

(+)-n,alpha-dimethyl-beta-phenylethylamine

(+)-N,alpha-Dimethyl-beta-phenylethylamine

(+)-n,alpha-dimethylphenethylamine

(+)-N,alpha-Dimethylphenethylamine

(+)-n-methylamphetamine

(+)-N-Methylamphetamine

(2S)-N-methyl-1-phenylpropan-2-amine

(2S)-N-Methyl-1-phenylpropan-2-amine

(AlphaS)-N,a-dimethylbenzeneethanamine

(alphaS)-N,alpha-dimethylbenzeneethanamine

(AlphaS)-N,alpha-dimethylbenzeneethanamine

(AlphaS)-N,α-dimethylbenzeneethanamine

(s)-(+)-deoxyephedrine

(S)-(+)-Deoxyephedrine

(s)-(+)-methamphetamine

(S)-(+)-Methamphetamine

(s)-(+)-n,alpha,dimethylphenethylamine

(S)-(+)-N,alpha,dimethylphenethylamine

(S)-(+)-N,alpha,Dimethylphenethylamine

(s)-methamphetamine

(S)-Methamphetamine

(s)-methylamphetamine

(S)-Methylamphetamine

(S)-N,a-Dimethylbenzeneethanamine

(s)-n,alpha-dimethylbenzeneethanamine

(S)-N,alpha-Dimethylbenzeneethanamine

(s)-n,alpha-dimethylbenzeneethanoamine

(S)-N,alpha-Dimethylbenzeneethanoamine

(S)-N,α-dimethylbenzeneethanamine

(αS)-N,α-dimethylbenzeneethanamine

139-47-9

14611-50-8

1690-86-4

1-Phenyl-2-methylamino-propan

1-Phenyl-2-methylamino-propan [German]

1-Phenyl-2-methylaminopropane

2S-(+)-Methamphetamine

45952-89-4

537-46-2

Abbott brand OF methamphetamine hydrochloride

AC1L1W1Z

AC1Q4SVR

B40

Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI)

Benzeneethanamine, N,alpha-dimethyl-, (S)- (9CI)

C07164

C10H15N

CHEBI:6809

CHEMBL1201201

CID10836

Crank

Crank [Street Name]

Crystal Meth

Crystal Meth [Street Name]

d-(S)-Methamphetamine

D-(s)-methamphetamine

D-(S)-Methamphetamine

D08187

D-1-Phenyl-2-methylaminopropan

d-1-Phenyl-2-methylaminopropan [German]

d-1-phenyl-2-methylaminopropane

D-1-Phenyl-2-methylaminopropane

DB01577

d-deoxyephedrine

d-Deoxyephedrine

D-deoxyephedrine

D-Deoxyephedrine

d-desoxyephedrine

d-Desoxyephedrine

D-desoxyephedrine

D-Desoxyephedrine

DEA No. 1105

Deoxyephedrine

desohyephedrine

Desoxyephedrine

Desoxyephedrine hydrochloride

Desoxyn

Desyphed

Desyphed hydrochloride

Dextromethamphetamine

d-Methamphetamine

D-methamphetamine

D-Methamphetamine

d-Methylamphetamine

D-methylamphetamine

D-Methylamphetamine

d-N,.alpha.-Dimethylphenethylamine

D-n,alpha-dimethylphenethylamine

D-N,alpha-dimethylphenethylamine

D-N,alpha-Dimethylphenethylamine

d-N-methylamphetamine

d-N-Methylamphetamine

D-n-methylamphetamine

D-N-Methylamphetamine

d-phenylisopropylmethylamine

d-Phenylisopropylmethylamine

D-phenylisopropylmethylamine

D-Phenylisopropylmethylamine

EINECS 208-668-7

HSDB 3359

Hydrochloride, methamphetamine

Ice

ICE [Street Name]

Langly brand OF methamphetamine hydrochloride

L-methamphetamine

L-Methamphetamine

LS-103331

Madrine

Metamfetamina

Metamfetamina [inn-spanish]

Metamfetamina [INN-Spanish]

Metamfetamine

Métamfétamine

Metamfetamine (INN)

Metamfetamine [INN]

Metamfetamine-m

Metamfetaminum

Metamfetaminum [inn-latin]

Metamfetaminum [INN-Latin]

Metamfetaminum [Latin]

Metamphetamine

Metanfetamina

Metanfetamina [inn-spanish]

Metanfetamina [INN-Spanish]

Metanfetamina [Spanish]

Meth

Meth (Street Name)

Methamphetamine

METHAMPHETAMINE

Methamphetamine hydrochloride

Methamphetamine, its salts, isomers, and salts of its isomers

Methamphetaminum

Methamphetaminum [inn-latin]

Methamphetaminum [INN-Latin]

Methamphetaminum [JP]

Methyl-.beta.-phenylisopropylamine

Methylamphetamine

Methyl-beta-phenylisopropylamine

Methyl-b-phenylisopropylamine

methyl-β-phenylisopropylamine

Methyl-β-phenylisopropylamine

MolPort-001-794-405

N Methylamphetamine

N-Methyl-1-phenyl-2-propanamine

N-methylamphetamine

N-Methylamphetamine

N-Methyl-beta-phenylisopropylamin

N-methyl-beta-phenylisopropylamin [german]

N-Methyl-beta-phenylisopropylamin [German]

N-methyl-beta-phenylisopropylamine

N-Methyl-beta-phenylisopropylamine

Norodin

NSC 25115

NSC25115

PDSP1_001404

PDSP1_001405

PDSP2_001388

PDSP2_001389

Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI)

S-(+)-methamphetamine

S-(+)-Methamphetamine

Speed

Speed [Street Name]

Stimulex

UNII-44RAL3456C

WLN: 1MY1&1R -D

Citric Acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citretten

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric Acid, Anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

uro-Trainer

glutamine

Not Applicable

Tryptophan

Antihypertensive Agents

Endothelin Receptor Antagonists

Sildenafil Citrate

171599-83-0

Phosphodiesterase Inhibitors

Vasodilator Agents

Citrate

Phosphodiesterase 5 Inhibitors

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis	Completed	NCT00891527	Phase 1, Phase 2	Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
2	Effects on Glutamine on the Outcome of Allogeneic Bone Marrow Transplant Recipients	Unknown status	NCT00563498	Not Applicable	Glutamine
3	Pharmacogenomics in Pulmonary Arterial Hypertension	Unknown status	NCT00593905		Sitaxsentan;Bosentan, Ambrisentan
4	Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)	Completed	NCT00666198		SILDENAFIL
5	Registration Study for Rare Type of Pulmonary Hypertension	Recruiting	NCT03169010

Search NIH Clinical Center for Pulmonary Venoocclusive Disease

Cochrane evidence based reviews: pulmonary veno-occlusive disease

Sources

Genetic Tests for Pulmonary Venoocclusive Disease

Genetic tests related to Pulmonary Venoocclusive Disease:

#	Genetic test	Affiliating Genes
1	Pulmonary Veno-Occlusive Disease ²⁹	BMPR2

Sources

Anatomical Context for Pulmonary Venoocclusive Disease

MalaCards organs/tissues related to Pulmonary Venoocclusive Disease:

⁴¹

Lung, Heart, Bone, Bone Marrow, Endothelial, Myeloid, Thyroid

Sources

Publications for Pulmonary Venoocclusive Disease

Articles related to Pulmonary Venoocclusive Disease:

(show top 50) (show all 229)

#	Title	Authors	Year
1	Pulmonary tumor thrombotic microangiopathy and pulmonary veno-occlusive disease in a woman with cervical cancer treated with cediranib and durvalumab. ( 29996818 )	Suffredini DA...Solomon MA	2018
2	Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog. ( 30518401 )	den Toom ML...Szatm?ri V	2018
3	Variable Expressivity of a Founder Mutation in the EIF2AK4 Gene in Hereditary Pulmonary Veno-occlusive Disease and Its Impact on Survival. ( 28697925 )	Navas Tejedor P...Escribano Sub?as P	2018
4	Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. ( 28958195 )	Zinter MS...Fineman JR	2018
5	Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease. ( 29108819 )	Nossent EJ...Dorfm?ller P	2018
6	Extracorporeal Membrane Oxygenation Support During Pregnancy in Pulmonary Veno-occlusive Disease. ( 29428338 )	Ortiz-Bautista C...Escribano-Sub?as P	2018
7	Clinical prediction score for identifying patients with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. ( 29548663 )	Ogawa A...Matsubara H	2018
8	Pulmonary veno-occlusive disease: pathogenesis, risk factors, clinical features and diagnostic algorithm - state of the art. ( 29960280 )	Szturmowicz M...Ku? J	2018
9	Lung transplantation as a viable option of treatment for pulmonary veno-occlusive disease. ( 30378654 )	Ochman M...Zembala M	2018
10	Use of vasodilators for the treatment of pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A systematic review. ( 30473253 )	Ogawa A...Tatsumi K	2018
11	Clinical features of canine pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 30499214 )	Reinero CR...Williams K	2018
12	Pulmonary Hypertension Associated with Pulmonary Veno-occlusive Disease in Patients with Polycythemia Vera. ( 28824072 )	Tachibana T....Nakajima H.	2017
13	Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study. ( 28087362 )	Montani D....Humbert M.	2017
14	Rapidly progressive pulmonary veno-occlusive disease in an infant with Down syndrome. ( 28782495 )	Muneuchi J...Shimizu D	2017
15	Pulmonary veno-occlusive disease as an occupational lung disease. ( 28463181 )	Montani D...Humbert M	2017
16	Pulmonary veno-occlusive disease: An important consideration in patients with pulmonary hypertension. ( 29229098 )	Balko R...Test V	2017
17	Prognostic significance of computed tomography criteria for pulmonary veno-occlusive disease in systemic sclerosis-pulmonary arterial hypertension. ( 29029203 )	Connolly MJ...Coghlan JG	2017
18	The First Experience of Pulmonary Veno-occlusive Disease Treatment With Macitentan and Sildenafil. ( 27840150 )	Chamorro Fern?ndez CI...Quezada Loaiza CA	2017
19	Pulmonary hypertension secondary to pulmonary veno-occlusive disease complicated by right heart failure, hypotension and acute kidney injury. ( 27872804 )	Golzy N...Hage A	2017
20	Pulmonary veno-occlusive disease: Two children with gradual disease progression. ( 28070482 )	Day RW...Alashari M	2017
21	Pulmonary veno-occlusive disease: characterising a rare but important disease. ( 28087361 )	Hadinnapola C...Morrell NW	2017
22	Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 28118962 )	Ortiz-Bautista C...Escribano-Sub?as P	2017
23	Myocardial injury in severe heritable pulmonary veno-occlusive disease. ( 28320632 )	Ortiz-Bautista C...Escribano-Sub?as P	2017
24	Sudden Death in a Patient with Pulmonary Veno-occlusive Disease (PVOD) and Severe Pulmonary Hypertension. ( 28768975 )	Saito M...Ohta K	2017
25	Efficacy and safety of long-term imatinib therapy for patients with pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis. ( 28947033 )	Ogawa A...Matsubara H	2017
26	Lung transplantation for mitomycin-induced pulmonary veno-occlusive disease. ( 29129416 )	Savale L...Montani D	2017
27	Pulmonary Veno-Occlusive Disease: Welcome to the PAHty (Bostonian for Party). ( 29158214 )	Miller DP...Farber HW	2017
28	Reactive Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-Occlusive Disease in a Patient with Repaired Scimitar Syndrome. ( 27069695 )	GA1ttinger E....Huber L.C.	2016
29	Favorable response to an endothelin receptor antagonist in mitomycin-induced pulmonary veno-occlusive disease with pulmonary capillary hemangiomatosis. ( 27045880 )	Koyama M....Miura T.	2016
30	Small Sample Lung Biopsy Findings in Patients With Clinicoradiologic Suspicion of Pulmonary Venoocclusive Disease-Pulmonary Capillary Hemangiomatosis. ( 27623416 )	Bal S.K....Christopher D.J.	2016
31	EIF2AK4 mutation in pulmonary veno-occlusive disease: A case report and review of the literature. ( 27684876 )		2016
32	Founder mutation C.3344C>t(p.Pro1115Leu) in the EIF2KA4 gene in iberian romani patients with pulmonary veno-occlusive disease: A warning for our daily practice. ( 26915523 )	Navas P...Escribano Sub?as P	2016
33	Pulmonary Veno-Occlusive Disease: A Newly Recognized Cause of Severe Pulmonary Hypertension in Dogs. ( 26926086 )	Williams K...Jutkowitz A	2016
34	Pulmonary veno-occlusive disease. ( 27009171 )	Montani D...Humbert M	2016
35	Letter by Belge et al Regarding Article, "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models". ( 27045135 )	Belge C...Delcroix M	2016
36	Response to Letter Regarding Article, "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Model". ( 27045136 )	Perros F...Montani D	2016
37	Scintigraphy Leading to the Misdiagnosis of Chronic Thromboembolic Disease in a Patient With Pulmonary Veno-Occlusive Disease. ( 27142608 )	Balke L...Bewig B	2016
38	Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs: Striking Similarities to the Human Condition. ( 27298303 )	Stenmark KR...Tuder RM	2016
39	Pulmonary Capillary Hemangiomatosis and Pulmonary Veno-occlusive Disease. ( 27514598 )	Chaisson NF...Elliott CG	2016
40	Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease. ( 26541523 )	Montani D....Humbert M.	2015
41	Pulmonary veno-occlusive disease: a rare cause of pulmonary hypertension. ( 25528660 )	Yahagi K...Virmani R	2015
42	Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models. ( 26130118 )	Perros F...Montani D	2015
43	Pulmonary veno-occlusive disease as a cause of pulmonary arterial hypertension. ( 26130886 )	Porres-Aguilar M...Abbas A	2015
44	Letter by Papangeli et al Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". ( 26169651 )	Papangeli I...Chun HJ	2015
45	Response to Letter Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease". ( 26169652 )	Lathen C...Thistlethwaite PA	2015
46	Gemcitabine-Induced Pulmonary Toxicity: A Case Report of Pulmonary Veno-Occlusive Disease. ( 26380562 )	Turco C...Borg C	2015
47	Pulmonary veno-occlusive disease: a rare cause of pulmonary hypertension in systemic sclerosis. Case presentation and review of the literature . ( 26402988 )	Daraban AM...Jurcu? R	2015
48	Mechanisms of exertional dyspnoea in pulmonary veno-occlusive disease with EIF2AK4 mutations. ( 25142489 )	Laveneziana P....Garcia G.	2014
49	EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension. ( 24292273 )	Eyries M....Soubrier F.	2014
50	Pulmonary venoocclusive disease in childhood. ( 24503954 )	Woerner C....Humpl T.	2014

Sources

Genes for Pulmonary Venoocclusive Disease

Genes related to Pulmonary Venoocclusive Disease (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	144.93	Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
2	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	46.4	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
3	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	18.32	DISEASES inferred ¹⁵
4	KCNK3	Potassium Two Pore Domain Channel Subfamily K Member 3	Protein Coding	16.02	DISEASES inferred ¹⁵
5	APLNR	Apelin Receptor	Protein Coding	15.63	DISEASES inferred ¹⁵
6	TBX4	T-Box 4	Protein Coding	15.21	DISEASES inferred ¹⁵

Sources

Variations for Pulmonary Venoocclusive Disease

Sources

Expression for Pulmonary Venoocclusive Disease

Search GEO for disease gene expression data for Pulmonary Venoocclusive Disease.

Sources

Pathways for Pulmonary Venoocclusive Disease

Pathways related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ALK1 signaling events ¹ Show member pathways ALK1 pathway ¹	10.05	ACVRL1 BMPR2

Sources

GO Terms for Pulmonary Venoocclusive Disease

Cellular components related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	8.92	ACVRL1 APLNR BMPR2 KCNK3

Biological processes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.77	ACVRL1 BMPR2 EIF2AK4
2	protein phosphorylation	GO:0006468	9.75	ACVRL1 BMPR2 EIF2AK4
3	angiogenesis	GO:0001525	9.63	ACVRL1 APLNR TBX4
4	negative regulation of cell growth	GO:0030308	9.58	ACVRL1 BMPR2
5	transforming growth factor beta receptor signaling pathway	GO:0007179	9.57	ACVRL1 BMPR2
6	BMP signaling pathway	GO:0030509	9.56	ACVRL1 BMPR2
7	positive regulation of endothelial cell proliferation	GO:0001938	9.55	ACVRL1 BMPR2
8	pattern specification process	GO:0007389	9.54	ACVRL1 BMPR2
9	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	9.52	ACVRL1 BMPR2
10	cellular response to BMP stimulus	GO:0071773	9.51	ACVRL1 BMPR2
11	positive regulation of BMP signaling pathway	GO:0030513	9.49	ACVRL1 BMPR2
12	blood vessel remodeling	GO:0001974	9.48	ACVRL1 BMPR2
13	transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	9.43	ACVRL1 BMPR2
14	activin receptor signaling pathway	GO:0032924	9.4	ACVRL1 BMPR2
15	negative regulation of DNA biosynthetic process	GO:2000279	9.37	ACVRL1 BMPR2
16	lymphangiogenesis	GO:0001946	9.32	ACVRL1 BMPR2
17	artery development	GO:0060840	9.26	ACVRL1 BMPR2
18	retina vasculature development in camera-type eye	GO:0061298	9.16	ACVRL1 BMPR2
19	lymphatic endothelial cell differentiation	GO:0060836	8.96	ACVRL1 BMPR2
20	venous blood vessel development	GO:0060841	8.62	ACVRL1 BMPR2

Molecular functions related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.61	ACVRL1 BMPR2 EIF2AK4
2	protein kinase activity	GO:0004672	9.58	ACVRL1 BMPR2 EIF2AK4
3	protein serine/threonine kinase activity	GO:0004674	9.54	ACVRL1 BMPR2 EIF2AK4
4	SMAD binding	GO:0046332	9.32	ACVRL1 BMPR2
5	growth factor binding	GO:0019838	9.26	ACVRL1 BMPR2
6	transforming growth factor beta-activated receptor activity	GO:0005024	9.16	ACVRL1 BMPR2
7	transmembrane receptor protein serine/threonine kinase activity	GO:0004675	8.96	ACVRL1 BMPR2
8	BMP receptor activity	GO:0098821	8.62	ACVRL1 BMPR2

Sources

Sources for Pulmonary Venoocclusive Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Pulmonary Venoocclusive Disease (PVOD)

Aliases & Classifications for Pulmonary Venoocclusive Disease

MalaCards integrated aliases for Pulmonary Venoocclusive Disease:

Classifications:

External Ids:

Summaries for Pulmonary Venoocclusive Disease

Related Diseases for Pulmonary Venoocclusive Disease

Diseases in the Pulmonary Venoocclusive Disease family:

Diseases related to Pulmonary Venoocclusive Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Pulmonary Venoocclusive Disease:

Symptoms & Phenotypes for Pulmonary Venoocclusive Disease

UMLS symptoms related to Pulmonary Venoocclusive Disease:

GenomeRNAi Phenotypes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Pulmonary Venoocclusive Disease:

Drugs & Therapeutics for Pulmonary Venoocclusive Disease

Drugs for Pulmonary Venoocclusive Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: pulmonary veno-occlusive disease

Genetic Tests for Pulmonary Venoocclusive Disease

Genetic tests related to Pulmonary Venoocclusive Disease:

Anatomical Context for Pulmonary Venoocclusive Disease

MalaCards organs/tissues related to Pulmonary Venoocclusive Disease:

Publications for Pulmonary Venoocclusive Disease

Articles related to Pulmonary Venoocclusive Disease:

Genes for Pulmonary Venoocclusive Disease

Genes related to Pulmonary Venoocclusive Disease (1 elite genes):

Variations for Pulmonary Venoocclusive Disease

Expression for Pulmonary Venoocclusive Disease

Pathways for Pulmonary Venoocclusive Disease

Pathways related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

GO Terms for Pulmonary Venoocclusive Disease

Cellular components related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

Biological processes related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

Molecular functions related to Pulmonary Venoocclusive Disease according to GeneCards Suite gene sharing:

Sources for Pulmonary Venoocclusive Disease