MCID: PLP002
MIFTS: 21

Pulp Degeneration

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulp Degeneration

MalaCards integrated aliases for Pulp Degeneration:

Name: Pulp Degeneration 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11189
ICD9CM 34 522.2
NCIt 49 C34962
SNOMED-CT 67 22361007
ICD10 32 K04.2
UMLS 71 C0034100

Summaries for Pulp Degeneration

MalaCards based summary : Pulp Degeneration is related to dental pulp calcification and suppurative periapical periodontitis. An important gene associated with Pulp Degeneration is DSPP (Dentin Sialophosphoprotein). The drugs Formaldehyde and Calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include salivary gland and bone.

Related Diseases for Pulp Degeneration

Diseases related to Pulp Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 dental pulp calcification 10.5
2 suppurative periapical periodontitis 9.9 DSPP AMBN
3 hypercementosis 9.9 DSPP AMBN
4 gingival recession 9.9 DSPP AMBN
5 trichodentoosseous syndrome 9.9 DSPP AMBN
6 hair whorl 9.9
7 tooth resorption 9.8 DSPP AMBN
8 dental fluorosis 9.8 DSPP AMBN
9 dentin dysplasia 9.8 DSPP AMBN
10 teeth hard tissue disease 9.7 DSPP AMBN
11 dental caries 9.7 DSPP AMBN
12 amelogenesis imperfecta 9.5 DSPP AMBN

Graphical network of the top 20 diseases related to Pulp Degeneration:



Diseases related to Pulp Degeneration

Symptoms & Phenotypes for Pulp Degeneration

Drugs & Therapeutics for Pulp Degeneration

Drugs for Pulp Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved 50-00-0 712
2
Calcium carbonate Approved, Investigational 471-34-1
3 Disinfectants
4 Anti-Infective Agents
5 Hemostatics
6 Calcium, Dietary
7
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical and Radiographic Evaluation of Biodentine Versus Formocresol in Vital Pulpotomy of Primary Molars: (A Randomized Control Clinical Trial) Completed NCT03582319
2 Intentional Pulpotomy to Preserve Vital Primary Molars With Challenging Restorability: a Feasibility Study Not yet recruiting NCT04385693

Search NIH Clinical Center for Pulp Degeneration

Genetic Tests for Pulp Degeneration

Anatomical Context for Pulp Degeneration

MalaCards organs/tissues related to Pulp Degeneration:

40
Salivary Gland, Bone

Publications for Pulp Degeneration

Articles related to Pulp Degeneration:

(show all 19)
# Title Authors PMID Year
1
Regressive changes of the dental pulp complex in retained primary molars with congenitally missing successor teeth. 54 61
9643208 1997
2
Success Rates of Pulpotomies in Primary Molars Using Calcium Silicate-Based Materials: A Randomized Control Trial. 61
29226134 2017
3
Minimally invasive clinical approach in indirect pulp therapy and healing of deep carious lesions. 61
25095310 2014
4
Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth. 61
24551447 2014
5
Effects of folk medicinal plant extract Ankaferd Blood Stopper(®) in vital primary molar pulpotomy. 61
22883359 2012
6
Success rates of mineral trioxide aggregate, ferric sulfate, and formocresol pulpotomies: a 24-month study. 61
21703067 2011
7
Rapid maxillary anterior teeth retraction en masse by bone compression: a canine model. 61
22039479 2011
8
Analysis of the dentin-pulp complex in teeth submitted to orthodontic movement in rats. 61
21499653 2009
9
Clinical, radiographic and histological analysis of the effects of mineral trioxide aggregate used in direct pulp capping and pulpotomies of primary teeth. 61
17256303 2006
10
Influence of the length of instrumentation and canal obturation on the success of endodontic therapy. A 10-year clinical follow-up. 61
16939025 2006
11
Aetiology, classification and pathogenesis of pulp and periapical disease. 61
15580137 2004
12
The success of emergency pulpotomies in primary molars. 61
12064494 2002
13
[Fractures of the alveolar process]. 61
9951348 1998
14
Tooth preparation and pulp degeneration. 61
9066221 1997
15
The diagnostic value of coronal dark-gray discoloration in primary teeth following traumatic injuries. 61
8784914 1996
16
Root resorption and pulpal changes due to intrusive force. 61
9582622 1994
17
Histopathology of furcation lesions associated with pulp degeneration in primary molars. 61
3507645 1987
18
[Causes of pulp degeneration]. 61
3858651 1985
19
[Clinical, etiopathogenetic and symptomatologic aspects of calcareous pulp degeneration]. 61
6585608 1983

Variations for Pulp Degeneration

Expression for Pulp Degeneration

Search GEO for disease gene expression data for Pulp Degeneration.

Pathways for Pulp Degeneration

GO Terms for Pulp Degeneration

Biological processes related to Pulp Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 8.62 DSPP AMBN

Sources for Pulp Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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