MCID: PLP002
MIFTS: 22

Pulp Degeneration

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulp Degeneration

MalaCards integrated aliases for Pulp Degeneration:

Name: Pulp Degeneration 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11189
ICD9CM 34 522.2
NCIt 50 C34962
SNOMED-CT 67 22361007
ICD10 32 K04.2
UMLS 71 C0034100

Summaries for Pulp Degeneration

MalaCards based summary : Pulp Degeneration is related to dental pulp calcification and suppurative periapical periodontitis. An important gene associated with Pulp Degeneration is DSPP (Dentin Sialophosphoprotein). The drugs Hemostatics and Calcium, Dietary have been mentioned in the context of this disorder.

Related Diseases for Pulp Degeneration

Diseases related to Pulp Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 dental pulp calcification 29.8 ENAM DSPP AMELX
2 suppurative periapical periodontitis 10.0 DSPP AMBN
3 gingival recession 10.0 DSPP AMBN
4 hypoplastic amelogenesis imperfecta 10.0 ENAM AMBN
5 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 9.9 AMELX AMBN
6 root caries 9.9 DSPP AMELX
7 hermansky-pudlak syndrome 6 9.9 AMELX AMBN
8 dental pulp necrosis 9.9 DSPP AMELX
9 amelogenesis imperfecta, type ic 9.9 ENAM AMELX
10 dental pulp disease 9.9 DSPP AMELX
11 hair whorl 9.8
12 papillary craniopharyngioma 9.8 ENAM AMELX
13 bone benign neoplasm 9.8 AMELX AMBN
14 amelogenesis imperfecta, type ie 9.8 AMELX AMBN
15 tooth resorption 9.7 DSPP AMELX AMBN
16 ameloblastoma 9.7 AMELX AMBN
17 brittle bone disorder 9.7 ENAM DSPP
18 dentine erosion 9.7 ENAM AMELX AMBN
19 enamel caries 9.7 ENAM AMELX AMBN
20 amelogenesis imperfecta, type ib 9.7 ENAM AMELX AMBN
21 amelogenesis imperfecta, type iiia 9.7 ENAM AMELX AMBN
22 hypercementosis 9.5 ENAM DSPP AMELX AMBN
23 tooth erosion 9.5 ENAM DSPP AMELX AMBN
24 trichodentoosseous syndrome 9.5 ENAM DSPP AMELX AMBN
25 dental fluorosis 9.5 ENAM DSPP AMELX AMBN
26 dentin dysplasia 9.5 ENAM DSPP AMELX AMBN
27 teeth hard tissue disease 9.5 ENAM DSPP AMELX AMBN
28 dental caries 9.5 ENAM DSPP AMELX AMBN
29 amelogenesis imperfecta 9.4 ENAM DSPP AMELX AMBN
30 tooth agenesis 9.4 ENAM DSPP AMELX AMBN

Graphical network of the top 20 diseases related to Pulp Degeneration:



Diseases related to Pulp Degeneration

Symptoms & Phenotypes for Pulp Degeneration

Drugs & Therapeutics for Pulp Degeneration

Drugs for Pulp Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hemostatics
2 Calcium, Dietary
3
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intentional Pulpotomy to Preserve Vital Primary Molars With Challenging Restorability: a Feasibility Study Not yet recruiting NCT04385693

Search NIH Clinical Center for Pulp Degeneration

Genetic Tests for Pulp Degeneration

Anatomical Context for Pulp Degeneration

Publications for Pulp Degeneration

Articles related to Pulp Degeneration:

(show all 21)
# Title Authors PMID Year
1
Regressive changes of the dental pulp complex in retained primary molars with congenitally missing successor teeth. 54 61
9643208 1997
2
Radiographic and Histologic Evaluation of Experimentally Induced Severe Intrusive Luxation of Immature Teeth in Rats. 61
32771418 2020
3
The Vital Pulp Therapy of Permanent Teeth: A Dental Practitioner's Perspective from Saudi Arabia. 61
32802776 2020
4
Success Rates of Pulpotomies in Primary Molars Using Calcium Silicate-Based Materials: A Randomized Control Trial. 61
29226134 2017
5
Minimally invasive clinical approach in indirect pulp therapy and healing of deep carious lesions. 61
25095310 2014
6
Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth. 61
24551447 2014
7
Effects of folk medicinal plant extract Ankaferd Blood Stopper(®) in vital primary molar pulpotomy. 61
22883359 2012
8
Success rates of mineral trioxide aggregate, ferric sulfate, and formocresol pulpotomies: a 24-month study. 61
21703067 2011
9
Rapid maxillary anterior teeth retraction en masse by bone compression: a canine model. 61
22039479 2011
10
Analysis of the dentin-pulp complex in teeth submitted to orthodontic movement in rats. 61
21499653 2009
11
Clinical, radiographic and histological analysis of the effects of mineral trioxide aggregate used in direct pulp capping and pulpotomies of primary teeth. 61
17256303 2006
12
Influence of the length of instrumentation and canal obturation on the success of endodontic therapy. A 10-year clinical follow-up. 61
16939025 2006
13
Aetiology, classification and pathogenesis of pulp and periapical disease. 61
15580137 2004
14
The success of emergency pulpotomies in primary molars. 61
12064494 2002
15
[Fractures of the alveolar process]. 61
9951348 1998
16
Tooth preparation and pulp degeneration. 61
9066221 1997
17
The diagnostic value of coronal dark-gray discoloration in primary teeth following traumatic injuries. 61
8784914 1996
18
Root resorption and pulpal changes due to intrusive force. 61
9582622 1994
19
Histopathology of furcation lesions associated with pulp degeneration in primary molars. 61
3507645 1987
20
[Causes of pulp degeneration]. 61
3858651 1985
21
[Clinical, etiopathogenetic and symptomatologic aspects of calcareous pulp degeneration]. 61
6585608 1983

Variations for Pulp Degeneration

Expression for Pulp Degeneration

Search GEO for disease gene expression data for Pulp Degeneration.

Pathways for Pulp Degeneration

GO Terms for Pulp Degeneration

Cellular components related to Pulp Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 KERA IST1 ENAM DSPP AMELX AMBN
2 endoplasmic reticulum lumen GO:0005788 9.33 ENAM AMELX AMBN
3 extracellular matrix GO:0031012 8.92 KERA ENAM DSPP AMELX

Biological processes related to Pulp Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.33 ENAM AMELX AMBN
2 odontogenesis of dentin-containing tooth GO:0042475 9.26 AMELX AMBN
3 cellular protein metabolic process GO:0044267 9.13 ENAM AMELX AMBN
4 biomineral tissue development GO:0031214 8.92 ENAM DSPP AMELX AMBN

Molecular functions related to Pulp Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.96 AMELX AMBN
2 structural constituent of tooth enamel GO:0030345 8.8 ENAM AMELX AMBN

Sources for Pulp Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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