MCID: PLP001
MIFTS: 48

Pulpitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

MalaCards integrated aliases for Pulpitis:

Name: Pulpitis 12 54 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD9CM 34 522.0
MeSH 43 D011671
NCIt 49 C52595
SNOMED-CT 67 32620007
ICD10 32 K04.0
UMLS 71 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and chickenpox. An important gene associated with Pulpitis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Lidocaine and Alprazolam have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 periapical periodontitis 31.6 TNF IL6 IL1B IL1A DSPP CXCL8
2 chickenpox 30.3 TNF IL6 CCR6
3 pain agnosia 30.2 TRPV1 TAC1 KNG1 IL6
4 bone resorption disease 30.1 TNF IL6 CCR6
5 trigeminal neuralgia 30.1 TRPV1 TAC1 SCN8A
6 root resorption 29.9 IL6 IL1B IL1A DSPP
7 uveitis 29.8 TNF IL6 IL1A CXCL8
8 bone inflammation disease 29.6 TNF MMP1 IL6 IL1B IL18 CXCL8
9 periodontitis 29.4 TNF TIMP1 MMP1 IL6 IL1B IL1A
10 contact dermatitis 29.3 TNF IL6 IL1B IL1A IL18 CXCL8
11 dermatitis 28.9 TNF IL6 IL1A IL18 CXCL8 CCR6
12 gingivitis 28.8 TNF MMP1 IL6 IL1B IL1A IL18
13 proteasome-associated autoinflammatory syndrome 1 28.6 TNF NOS2 IL6 IL1B IL1A IL18
14 dental pulp necrosis 11.6
15 external pathological resorption 10.6 TNF IL6
16 scorpion envenomation 10.6 TNF IL6
17 angelucci's syndrome 10.6 IL1B CXCL8
18 dermatitis, atopic, 8 10.6 IL1B CXCL8
19 staphylococcal toxic shock syndrome 10.5 TNF IL1B
20 acute transverse myelitis 10.5 IL6 CXCL8
21 prosthetic joint infection 10.5 IL6 IL1B
22 osteosclerotic myeloma 10.5 IL6 IL1B
23 esophagus melanoma 10.5 IL1B CXCL8
24 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
25 vulvar vestibulitis syndrome 10.5 TNF IL1B
26 palladium allergic contact dermatitis 10.5 TNF IL1B
27 kashin-beck disease 10.5 TNF IL1B
28 conjunctivitis 10.5 TNF IL6 CXCL8
29 idiopathic anterior uveitis 10.5 TNF IL6 CXCL8
30 streptococcal toxic-shock syndrome 10.5 TNF IL6 CXCL8
31 recurrent corneal erosion 10.5 IL6 IL1B CXCL8
32 bronchiolitis 10.5 TNF IL6 CXCL8
33 transverse myelitis 10.5 TNF IL6 CXCL8
34 fuchs' heterochromic uveitis 10.5 IL6 CXCL8
35 ascaris lumbricoides infection 10.5 IL6 IL1B CXCL8
36 haemophilus influenzae 10.5 TNF CXCL8
37 cardiac sarcoidosis 10.5 TNF IL1B CXCL8
38 chlamydia pneumonia 10.5 TNF IL6 CXCL8
39 opisthorchiasis 10.5 TNF IL1B CXCL8
40 trichomoniasis 10.5 TNF IL6 CXCL8
41 toxicodendron dermatitis 10.5 TNF CXCL8
42 urethritis 10.4 TNF IL6 CXCL8
43 viral pneumonia 10.4 TNF IL6 CXCL8
44 blood group, globoside system 10.4 TNF IL6 CXCL8
45 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1B IL18
46 spotted fever rickettsiosis 10.4 TNF NOS2
47 glossitis 10.4 TNF IL6 IL1B
48 macular retinal edema 10.4 TNF IL6 CXCL8
49 uremic pruritus 10.4 IL6 IL1B IL18
50 meconium aspiration syndrome 10.4 TNF IL6 CXCL8

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

MGI Mouse Phenotypes related to Pulpitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ASH1L CALCRL CCR6 CD163 IL18 IL1A
2 homeostasis/metabolism MP:0005376 10.1 ASH1L BLVRB CALCRL CCR6 CD163 IL18
3 hematopoietic system MP:0005397 10.06 ASH1L CALCRL CCR6 CD163 IL18 IL1A
4 immune system MP:0005387 9.97 ASH1L CALCRL CCR6 CD163 IL18 IL1A
5 integument MP:0010771 9.65 ASH1L CALCRL IL18 IL1A IL1B IL6
6 neoplasm MP:0002006 9.23 IL1A IL1B IL6 MMP1 NOS2 TIMP1

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
3
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
8
Ibuprofen Approved Phase 4 15687-27-1 3672
9
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282241 5282242
10
Etodolac Approved, Investigational, Vet_approved Phase 4 41340-25-4 3308
11
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
12
Racepinephrine Approved Phase 4 329-65-7 838
13
Clonidine Approved Phase 4 4205-90-7 2803
14 Anti-Arrhythmia Agents Phase 4
15 Sodium Channel Blockers Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Analgesics, Non-Narcotic Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Antirheumatic Agents Phase 4
22 Tranquilizing Agents Phase 4
23 Psychotropic Drugs Phase 4
24 GABA Agents Phase 4
25 Anti-Anxiety Agents Phase 4
26 GABA Modulators Phase 4
27 Antiemetics Phase 4
28 Gastrointestinal Agents Phase 4
29 Hormone Antagonists Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 glucocorticoids Phase 4
32 Hormones Phase 4
33 HIV Protease Inhibitors Phase 4
34
protease inhibitors Phase 4
35 BB 1101 Phase 4
36 Antipyretics Phase 4
37 Cyclooxygenase 2 Inhibitors Phase 4
38 Dexketoprofen trometamol Phase 4
39 Chlorhexidine gluconate Phase 4
40 Epinephryl borate Phase 4
41 Anti-Asthmatic Agents Phase 4
42 Adrenergic beta-Agonists Phase 4
43 Bronchodilator Agents Phase 4
44 Analgesics Phase 4
45 Carticaine Phase 4
46 Antihypertensive Agents Phase 4
47 Adrenergic alpha-2 Receptor Agonists Phase 4
48 Sympatholytics Phase 4
49
Diclofenac Approved, Vet_approved Phase 2, Phase 3 15307-86-5 3033
50
Mannitol Approved, Investigational Phase 2, Phase 3 69-65-8 453 6251

Interventional clinical trials:

(show top 50) (show all 155)
# Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
3 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Unknown status NCT02201641 Phase 4
4 Effect of Preoperative Alprazolam on the Success of Inferior Alveolar Nerve Block for Teeth With Irreversible Pulpitis Completed NCT01546090 Phase 4 Alprazolam;placebo
5 Anesthetic Efficacy of Articaine, Lidocaine and Mepivacaine in Patients With Irreversible Pulpitis of Mandibular Molar Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
6 The Effect of Preoperative Oral Administration of Prednisolone on Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Single Center Randomized Controlled Trial Completed NCT02819648 Phase 4 Prednisolone
7 Efficacy of the Combination Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial. Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
8 Articaine Versus Lidocaine Supplemental Infiltration Efficacy in Irreversible Pulpitis Mandibular Molars After Failed Inferior Alveolar Nerve Block Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
9 Anesthetic Efficacy of 4% Articaine (Mandibular Infiltration) and 2% Lidocaine (Alveolar Nerve Block), Associated With 1:100.000 Epinephrine, in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
10 Effectiveness of Dexketoprofen Trometamol in the Management of Postoperative Endodontic Pain. Controlled Clinical Trial of Multiple Doses Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
11 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
12 An Evaluation of Postoperative Pain Using Ibuprofen Versus Ibuprofen/Acetaminophen in Patients With Symptomatic Irreversible Pulpitis and Symptomatic Apical Periodontitis Completed NCT03631433 Phase 4 Ibuprofen 600 mg;ibuprofen 600 mg and acetaminophen 650 mg
13 Preemptive Use of Etodolac on Tooth Sensitivity Caused by In-office Bleaching: a Randomized, Triple-blind, Controlled Clinical Trial Completed NCT02881619 Phase 4 Etodolac;Placebo
14 Indirect Pulp Capping, Direct Pulp Capping, Partial Pulpotomy, Pulpotomy of Primary Molars Using TheraCal; A Randomized Clinical Trial Recruiting NCT04167943 Phase 4 Dual cured resin modified tricalcium silicate cement
15 The Effect of Buccal Infiltration Administration of Clonidine on the Success Rate of Inferior Alveolar Nerve Block on Mandibular Molars With Symptomatic Irreversible Pulpitis: a Randomized Double-blind Clinical Trial Not yet recruiting NCT04186299 Phase 4 Clonidine;Articaine Hydrochloride + Epinephrine
16 Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Withdrawn NCT03502135 Phase 4 Tetracaine HCl and oxymetazoline HCl nasal spray
17 Effect of Pre-operative Diclofenac Potassium on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Cases With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial Unknown status NCT03163420 Phase 2, Phase 3 Diclofenac potassium
18 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial Completed NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
19 Effect of Addition of 0.5 Mol/L Mannitol to 0.5% Bupivacaine on IANB Success and Post-endodontic Pain in Mandibular Molars With Irreversible Pulpitis: A Randomized Clinical Trial Completed NCT03749408 Phase 2, Phase 3 bupivacaine plus mannitol;bupivacaine alone
20 Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial Completed NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
21 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
22 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
23 Effect of Pre-operative Aceclofenac on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
24 Effect of Lidocaine/Dexamethasone on the Success of IANB in Patients With Irreversible Pulpitis Completed NCT03531970 Phase 2, Phase 3 2% lidocaine with 1:80,000 epinephrine;Dexamethasone;Placebo
25 Efficacy of Oral Prednisolone Versus Partial Endodontic Treatment on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis of Mandibular Molars: Non Inferiority Randomized Clinical Trial Completed NCT02629042 Phase 3 prednisolone
26 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block in the Mandibular First Molar With Symptomatic Irreversible Pulpitis: a Prospective, Randomized Double-blind Study Completed NCT02726737 Phase 3 sodium bicarbonate;Lidocaine;sterile distilled water
27 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment: A Randomized, Double-blind, Placebo-controlled Trial Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
28 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
29 Partial Pulpotomy on Caries Free Human Teeth Using iRootBP and White ProRoot MTA: a Randomized Controlled Trial Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
30 EVALUATION OF CLINICAL EFFICACY AND SENSIBILITY OF BLEACHING AGENT 37% CARBAMIDE PEROXIDE IN-OFFICE TOOTH BLEACHING: CLINICAL TRIAL RANDOMIZED CONTROLLED Completed NCT02935114 Phase 3 37% Carbamide Peroxide;35% hydrogen Peroxide
31 Preemptive Use of Piroxicam-beta-Cyclodextrin on Tooth Sensitivity Caused by In-office Bleaching: Randomized, Triple-blind, Controlled Clinical Trial Completed NCT03153657 Phase 3 Piroxicam-Beta-Cyclodextrin;Placebo
32 Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine for Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial PART 6 Recruiting NCT03725579 Phase 2, Phase 3 mepivicane hydrochloride;articane hydrochloride
33 Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017: A Double Blind Randomized Controlled Trial Recruiting NCT03488836 Phase 2, Phase 3
34 Regenerative Endodontic Procedure of Immature Permanent Teeth With the Use of Autologous L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
35 Comparative Evaluation of Preoperative Methylprednisolone or Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis Not yet recruiting NCT04157036 Phase 3 Ibuprofen;Methylprednisolone
36 Clinical Study: Evaluation of the Antibacterial Effect of Insoluble Antibacterial Nanonparticles Incorporated in Dental Materials for Endodontic Treatment Unknown status NCT01167985 Phase 2
37 Effect Of Different Lining Materials on Clinical Symptoms of Stepwise Excavation Without Re-enter: Double Blind Randomizd Clinical Trial Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
38 Comparison the Effect of Lidocaine (With Epinephrine) With and Without Sufentanil on the Rate of Anesthesia of Intra-ligamentary Injection in Teeth With Irreversible Pulpitis Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
39 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
40 Analgesic Efficacy of a Combination of Fentanyl and Lidocaine for Maxillary Infiltration in Teeth With Irreversible Pulpitis Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
41 the Effect of Intraligamentary Injection of Lornoxicam on the Intensity of Post-operative Endodontic Pain in the Tooth With Symptomatic Irreversible Pulpitis Completed NCT01480752 Phase 2 Lornoxicam;normal saline;no injection
42 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Completed NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
43 Efficacy of Ketorolac and Lidocaine Inferior Alveolar Nerve Blocks in Patients With With Symptomatic Irreversible Pulpitis: a Prospective Double Blind, Randomized Clinical Trial Completed NCT03410212 Phase 2 Ketorolac Tromethamine
44 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block in Patients With Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial Completed NCT02536430 Phase 2 Ketorolac Tromethamine;Placebo
45 Efficacy of Pressure Massage and Topical Gel on Pain During Inferior Alveolar Nerve Block and Maxillary Anterior Injections: A Single-Blind Randomized Clinical Trial Completed NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
46 Comparative Efficacy of Gow-Gates and Inferior Alveolar Nerve Block Injection Techniques on Success Rate of Anesthesia in Patients With Symptomatic Irreversible Pulpitis Completed NCT02543619 Phase 2
47 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Endodontic Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
48 Comparison of the Success Rate of Anesthesia Between Lidocaine 2% and Lidocaine 2% Mixed With 10% Magnesium Sulfate in the Inferior Alveolar Nerve Block in Posterior Teeth With Irreversible Pulpitis Completed NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
49 Comparison of Ketorolac and Ketorolac/Acetaminophen on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
50 Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

40
Bone, Testes, Heart, Liver, Monocytes, Eye, Trigeminal Ganglion

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 1539)
# Title Authors PMID Year
1
Indirect pulp treatment in primary teeth: 4-year results. 54 61
20437725 2010
2
Effect of adhesive restorations over incomplete dentin caries removal: 5-year follow-up study in primary teeth. 54 61
19619424 2009
3
Immunohistochemical localization of LIM mineralization protein 1 in pulp-dentin complex of human teeth with normal and pathologic conditions. 54 61
18215669 2008
4
Vanilloid receptor 1 expression in human tooth pulp in relation to caries and pain. 54 61
16106719 2005
5
Willingness to pay for dentin regeneration in a sample of dentate adults. 54 61
15151691 2004
6
Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. 54 61
14520770 2003
7
Differential regulation of interleukin-6 and inducible cyclooxygenase gene expression by cytokines through prostaglandin-dependent and -independent mechanisms in human dental pulp fibroblasts. 54 61
12017180 2002
8
Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1alpha and tumor necrosis factor-alpha through a prostaglandin-dependent pathway. 54 61
11487149 2001
9
Bradykinin levels in dental pulp by microdialysis. 54 61
11471646 2000
10
The association of carious dentin microflora with tissue changes in human pulpitis. 54 61
8510981 1993
11
Medication of the dental pulp: a review and proposals. 54 61
1396354 1992
12
Berberine reduces inflammation of human dental pulp fibroblast via miR-21/KBTBD7 axis. 61
31837588 2020
13
Pulpal anesthesia in pediatric patients following supplemental mandibular buccal infiltration in vital permanent mandibular molars with deep caries. 61
31270668 2020
14
ACTN2 (rs6656267) and MPPED2 (rs11031093 and rs536007) polymorphisms in primary dentition caries: a case control study. 61
32040219 2020
15
The effect of pretreatment submucosal injections of tramadol and dexamethasone on post-endodontic pain in mandibular molar teeth with symptomatic irreversible pulpitis: a randomized controlled clinical trial. 61
31702056 2020
16
Effect of magnesium sulphate added to lidocaine on inferior alveolar nerve block success in patients with symptoms of irreversible pulpitis: a prospective, randomized clinical trial. 61
31306506 2020
17
Different anesthetics on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A network systematic review and meta-analysis. 61
31813471 2020
18
Is articaine more effective than lidocaine in patients with irreversible pulpitis? An umbrella review. 61
31491042 2020
19
Role(s) of cytokines in pulpitis: Latest evidence and therapeutic approaches. 61
31670007 2020
20
A histological and ultrastructural study of equine peripheral caries. 61
31038757 2020
21
Minimally interventive restorative care of teeth with molar incisor hypomineralization and open apex-A 24-month longitudinal study. 61
31593607 2020
22
Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. 61
31902641 2020
23
Ageing affects the proliferation and mineralization of rat dental pulp stem cells under inflammatory conditions. 61
31419325 2020
24
High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study. 61
31247107 2020
25
Impact of Epigenetic alterations in the development of oral diseases. 61
31942842 2020
26
Revascularization and vital pulp therapy in immature molars with necrotic pulp and irreversible pulpitis: A case report with two-year follow-up. 61
31998518 2020
27
Efficacy of submucosal tramadol and lidocaine on success rate of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis. 61
31953787 2020
28
Role of transient receptor potential vanilloid type 1 in the trigeminal ganglion and brain stem following dental pulp inflammation. 61
31411737 2020
29
Anaesthetic efficacy of 2% lidocaine with different concentrations of epinephrine (1:80,000 and 1:200,000) in intraligamentary injection after a failed primary inferior alveolar nerve block: a randomized double-blind study. 61
31821059 2019
30
IGFBP5 promotes angiogenic and neurogenic differentiation potential of dental pulp stem cells. 61
31599466 2019
31
Managing post endodontic treatment pain by eliminating occlusal contacts. 61
31863044 2019
32
Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study. 61
31811497 2019
33
Dental characteristics and according treatments of children under GA in Germany. 61
31124081 2019
34
The protective effects of saxagliptin against lipopolysaccharide (LPS)-induced inflammation and damage in human dental pulp cells. 61
30942641 2019
35
Dentinal dysplasia type 1: A 3D micro-computed tomographic study of enamel, dentine and root canal morphology. 61
31310441 2019
36
Lipopolysaccharide-induced DNA damage response activates nuclear factor κB signalling pathway via GATA4 in dental pulp cells. 61
31260564 2019
37
Efficacy and Safety of Pulpal Anesthesia Strategies during Endodontic Treatment of Permanent Mandibular Molars with Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta-analysis. 61
31601433 2019
38
Effectiveness Of Pre-operative Oral Medication of Ibuprofen and Ketorolac on Anesthetic Efficacy of Inferior Alveolar Nerve Block with Irreversible Pulpitis: Randomized Controlled Trial. 61
31938633 2019
39
Cryotherapy may increase the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis who undergo endodontic treatment. 61
31627833 2019
40
MicroRNA-506 Is Involved in Regulation of the Occurrence of Lipopolysaccharides (LPS)-Induced Pulpitis by Sirtuin 1 (SIRT1). 61
31877121 2019
41
Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: Systematic review and meta-analysis-a report of the American Dental Association. 61
31761029 2019
42
Plain language summary for "Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: systematic review and meta-analysis-a report of the American Dental Association". 61
31761018 2019
43
Maternal-related factors in the origin of isolated cleft palate-A population-based case-control study. 61
31854100 2019
44
Orofacial Pain and Menstrually Related Migraine. 61
32026457 2019
45
Interventions for anesthetic success in symptomatic irreversible pulpitis: A network meta-analysis of randomized controlled trials. 61
31942448 2019
46
Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. 61
31865629 2019
47
Treatment preferences for deep caries lesions among Australian dentists. 61
31773749 2019
48
Outcome of Partial Pulpotomy in Cariously Exposed Posterior Permanent Teeth: A Systematic Review and Meta-analysis. 61
31515048 2019
49
Altmetric analysis of the contemporary scientific literature in Endodontology. 61
31566775 2019
50
Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association. 61
31668170 2019

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 TNF TIMP1 NOS2 IL6 IL1B IL1A
2
Show member pathways
13.72 TNF TIMP1 NOS2 IL6 IL1B IL1A
3
Show member pathways
13.46 TNF TIMP1 IL6 IL1B IL1A IL18
4
Show member pathways
13.41 TNF TIMP1 NOS2 MMP1 IL6 IL1B
5
Show member pathways
13.35 TNF TIMP1 IL6 IL1B IL1A IL18
6
Show member pathways
13.17 TNF NOS2 KNG1 IL6 IL1B IL18
7
Show member pathways
12.88 TNF IL6 IL1B IL1A IL18 CXCL8
8
Show member pathways
12.87 TNF IL6 IL1B IL1A CXCL8
9 12.86 NOS2 MMP1 KNG1 IL6 CXCL8
10
Show member pathways
12.79 TNF IL6 IL1B IL18 CXCL8
11
Show member pathways
12.74 TNF TIMP1 IL6 IL1B IL1A
12
Show member pathways
12.66 TNF TIMP1 NOS2 IL6 IL1B IL18
13
Show member pathways
12.65 TNF IL6 IL1B IL1A IL18
14 12.41 TNF IL1B IL18 CXCL8
15
Show member pathways
12.41 TNF MMP1 IL6 IL1B CXCL8
16
Show member pathways
12.4 TNF IL6 IL18 CXCL8 CCR6
17
Show member pathways
12.39 TNF NOS2 IL6 IL1B IL1A CXCL8
18 12.37 TNF IL6 IL1B IL18 CXCL8
19 12.31 TNF IL6 IL1B IL18 CXCL8
20
Show member pathways
12.31 TNF TIMP1 IL6 IL1B IL1A IL18
21
Show member pathways
12.3 TNF IL6 IL1A CXCL8
22
Show member pathways
12.3 TNF NOS2 IL1B IL1A
23 12.28 TNF NOS2 IL6 IL1B IL1A IL18
24
Show member pathways
12.26 TNF NOS2 IL6 IL1B CXCL8
25 12.23 TNF NOS2 MMP1 IL6
26 12.22 TNF TAC1 IL6 IL1B IL1A CXCL8
27
Show member pathways
12.22 TNF NOS2 IL6 IL1B IL1A IL18
28
Show member pathways
12.12 TNF IL6 IL1B IL18
29 12.09 TNF IL6 IL1B IL18 CXCL8
30 12.03 TNF NOS2 IL6 IL1B IL1A CXCL8
31 12.02 IL6 IL1B IL1A CXCL8
32 12 TNF NOS2 IL6 IL1B CXCL8
33 11.98 TNF IL6 IL1B IL1A
34 11.98 TNF IL6 IL1B IL1A CXCL8
35 11.87 TNF IL1B IL18 CCR6
36 11.83 MMP1 IL6 CXCL8
37 11.83 TNF IL6 IL1B CD163
38 11.78 NOS2 IL6 IL1B IL1A IL18 CXCL8
39 11.77 TNF MMP1 IL6 IL1B IL1A IL18
40 11.73 TNF NOS2 IL6 IL1B IL1A CXCL8
41 11.72 TNF TIMP1 IL6 IL1B CXCL8
42 11.69 TIMP1 MMP1 CXCL8
43 11.66 TNF IL6 IL1B IL18 CXCL8
44 11.65 TNF NOS2 IL6 IL1B IL18 CD163
45 11.64 NOS2 MMP1 IL6 CXCL8
46 11.63 NOS2 IL6 CXCL8
47 11.61 TNF NOS2 IL1B IL18
48 11.59 TNF IL6 IL1B IL18 CXCL8
49 11.58 TNF IL6 IL1B IL1A
50 11.57 IL6 IL1B IL1A

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF TIMP1 TAC1 KNG1 IL6 IL1B
2 extracellular region GO:0005576 9.4 TNF TIMP1 TAC1 MMP1 KNG1 IL6

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 TNF IL6 IL1B IL1A IL18
2 cellular protein metabolic process GO:0044267 9.96 TIMP1 MMP1 KNG1 IL6
3 cell-cell signaling GO:0007267 9.96 TAC1 IL1B IL18 ASH1L
4 immune response GO:0006955 9.95 TNF IL6 IL1B IL1A IL18 CXCL8
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 TRPV1 TAC1 KNG1 CCR6
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 TNF IL6 IL1B IL18
7 positive regulation of inflammatory response GO:0050729 9.86 TNF IL1B IL18
8 positive regulation of JNK cascade GO:0046330 9.85 TNF IL1B IL1A
9 neutrophil chemotaxis GO:0030593 9.85 IL1B IL1A CXCL8
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 TNF IL6 IL18
11 cellular response to organic cyclic compound GO:0071407 9.82 TNF IL1B IL18
12 regulation of insulin secretion GO:0050796 9.82 TNF NOS2 IL1B
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF IL1B IL18
14 response to hormone GO:0009725 9.8 TIMP1 TAC1 NOS2
15 cellular response to lipopolysaccharide GO:0071222 9.8 TNF NOS2 IL6 IL1B IL1A CXCL8
16 humoral immune response GO:0006959 9.79 TNF IL6 CCR6
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TRPV1 TNF IL1B
18 positive regulation of interleukin-6 production GO:0032755 9.76 TNF IL6 IL1B IL1A
19 positive regulation of interferon-gamma production GO:0032729 9.75 TNF IL1B IL18
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 TNF IL6 IL18 CALCRL
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.72 TNF IL1B IL1A
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TNF IL1B IL18
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.69 IL6 IL1B IL1A
24 neutrophil activation GO:0042119 9.68 IL18 CXCL8
25 negative regulation of heart rate GO:0010459 9.68 TRPV1 TAC1
26 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IL1B
27 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 IL1B IL18
28 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
29 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
30 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
31 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
32 ectopic germ cell programmed cell death GO:0035234 9.63 IL1B IL1A
33 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.61 IL1B IL18
34 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
35 cytokine-mediated signaling pathway GO:0019221 9.61 TNF TIMP1 NOS2 MMP1 IL6 IL1B
36 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.6 TIMP1 IL1A
37 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
39 interleukin-6 production GO:0032635 9.54 IL1B IL18 ASH1L
40 positive regulation of neuroinflammatory response GO:0150078 9.46 TNF IL6 IL1B IL18
41 fever generation GO:0001660 9.43 TRPV1 IL1B IL1A
42 inflammatory response GO:0006954 9.32 TRPV1 TNF TAC1 KNG1 IL6 IL1B

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF TIMP1 IL6 IL1B IL1A IL18

Sources for Pulpitis

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68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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