MCID: PLP001
MIFTS: 50

Pulpitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

MalaCards integrated aliases for Pulpitis:

Name: Pulpitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD10 33 K04.0
ICD9CM 35 522.0
MeSH 44 D011671
NCIt 50 C52595
SNOMED-CT 68 32620007
UMLS 73 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and periodontitis. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related phenotypes are cardiovascular system and integument

Wikipedia : 76 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 periapical periodontitis 32.1 TNF IL6 IL1B DSPP
2 periodontitis 30.1 TNF MMP1 IL6 IL1B IL1A CXCL8
3 root resorption 29.9 DSPP IL1A IL1B
4 contact dermatitis 29.7 TNF IL6 IL1B IL1A CXCL8
5 bone inflammation disease 29.1 TRPV1 TNF MMP1 IL6 IL1B IL1A
6 dental pulp necrosis 11.1
7 cyclic neutropenia 10.3 IL1B CXCL8
8 ascaris lumbricoides infection 10.3 IL1B CXCL8
9 peptic esophagitis 10.3 IL1B CXCL8
10 trichuriasis 10.3 TNF CXCL8
11 cardiac sarcoidosis 10.3 TNF CXCL8
12 clonorchiasis 10.3 TNF CXCL8
13 periodontosis 10.3 TNF CXCL8
14 actinic prurigo 10.3 TNF IL1B
15 mycobacterium abscessus 10.3 TNF CXCL8
16 retinitis pigmentosa 60 10.3 TNF IL1B
17 burns 10.3 TNF IL1B
18 primary systemic mycosis 10.3 TNF IL1B
19 jejunoileitis 10.3 TNF IL1B
20 viral meningitis 10.3 IL6 CXCL8
21 denture stomatitis 10.3 IL6 CXCL8
22 rheumatoid lung disease 10.3 TNF IL1B
23 capillary leak syndrome 10.3 IL6 CXCL8
24 congenital cytomegalovirus 10.3 TNF IL1B
25 papillary conjunctivitis 10.3 IL6 CXCL8
26 pyelitis 10.3 IL6 CXCL8
27 vulvar vestibulitis syndrome 10.3 TNF IL1B
28 cowpox 10.3 IL6 CXCL8
29 necrotizing fasciitis 10.3 IL6 CXCL8
30 acute monoblastic leukemia 10.3 IL6 CXCL8
31 cysticercosis 10.3 IL6 IL1B
32 euthyroid sick syndrome 10.3 IL6 IL1B
33 uremic pruritus 10.3 IL6 IL1B
34 retinitis pigmentosa 55 10.3 TNF IL6
35 ischemic heart disease 10.3 TNF IL6
36 autoimmune gastritis 10.3 TNF IL6
37 juvenile ankylosing spondylitis 10.3 TNF IL6
38 autoimmune disease of eyes, ear, nose and throat 10.3 TNF IL6
39 listeriosis 10.3 TNF IL6
40 posterior uveitis 10.3 TNF IL6
41 intermediate uveitis 10.3 TNF IL6
42 crimean-congo hemorrhagic fever 10.3 TNF IL6
43 mycoplasma pneumoniae pneumonia 10.3 TNF IL6
44 hypersensitivity reaction type iii disease 10.3 TNF IL6
45 null-cell leukemia 10.3 TNF IL6
46 anca-associated vasculitis 10.3 TNF IL6
47 anterior uveitis 10.3 TNF IL6
48 posterior urethral valves 10.3 TNF IL6
49 hemorrhagic fever 10.2 TNF IL6
50 scabies 10.2 IL1A CXCL8

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

MGI Mouse Phenotypes related to Pulpitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ASH1L IL1A IL1B IL6 SCN8A TNF
2 integument MP:0010771 9.43 ASH1L IL1A IL1B IL6 TNF TRPV1
3 neoplasm MP:0002006 9.1 IL1A IL1B IL6 MMP1 TNF TRPV1

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
2
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
4
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
5
Mepivacaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 96-88-8 4062
6
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
7
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
9
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
10
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
12
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
13
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
14
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
15
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Not Applicable 69-72-7 338
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-02-2 5743
17
Ceftibuten Approved, Investigational Phase 4,Not Applicable 97519-39-6 5282241 5282242
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 1177-87-3
19
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
20
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
21
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
22
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 16682734 105143
23 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
24 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
25 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
26 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
28 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
29 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
31 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
32 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
33 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
34 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
35 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
37 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Mydriatics Phase 4,Phase 3,Phase 2,Not Applicable
39 Analgesics, Opioid Phase 4,Phase 2,Phase 1
40 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
42 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
43 Narcotics Phase 4,Phase 2,Phase 1
44 Sympathomimetics Phase 4,Phase 3,Phase 2,Not Applicable
45 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Not Applicable
46 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
50 Dexketoprofen trometamol Phase 4

Interventional clinical trials:

(show top 50) (show all 115)
# Name Status NCT ID Phase Drugs
1 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
4 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
5 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
6 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
7 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
8 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
9 Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block Completed NCT01546090 Phase 4 Alprazolam;placebo
10 Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy Completed NCT03631433 Phase 4 Ibuprofen 600 mg;ibuprofen 600 mg and acetaminophen 650 mg
11 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
12 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
13 Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Withdrawn NCT03502135 Phase 4 Tetracaine HCl and oxymetazoline HCl nasal spray
14 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Unknown status NCT03163420 Phase 2, Phase 3 Diclofenac potassium
15 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
16 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Completed NCT02629042 Phase 3 prednisolone
17 Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain Completed NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
18 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Completed NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
19 Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain Completed NCT03749408 Phase 2, Phase 3 bupivacaine plus mannitol;bupivacaine alone
20 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
21 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
22 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
23 Effect of Lidocaine/Dexamethasone on the Success of IANB Completed NCT03531970 Phase 2, Phase 3 2% lidocaine with 1:80,000 epinephrine;Dexamethasone;Placebo
24 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block Completed NCT02726737 Phase 3 sodium bicarbonate;Lidocaine;sterile distilled water
25 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
26 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
27 Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine Recruiting NCT03725579 Phase 2, Phase 3 mepivicane hydrochloride;articane hydrochloride
28 Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017 Recruiting NCT03488836 Phase 2, Phase 3
29 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques Recruiting NCT02601833 Phase 3
30 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
31 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
32 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
33 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
34 Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain Completed NCT03410212 Phase 2 Ketorolac Tromethamine
35 Reduction of Post-operative Endodontic Pain Completed NCT01480752 Phase 2 Lornoxicam;normal saline;no injection
36 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Completed NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
37 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
38 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
39 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
40 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block Completed NCT02536430 Phase 2 Ketorolac Tromethamine;Placebo
41 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Completed NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
42 Efficacy of Two Injection Techniques on Success Rate of Inferior Alveolar Nerve Anesthesia Completed NCT02543619 Phase 2
43 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
44 Effect of High-dose Naloxone Following Third Molar Extraction Recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
45 Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block Active, not recruiting NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
46 Ketorolac Premedication for Anesthetic Efficiency of IANB & Postendodontic Pain in Teeth With Irreversible Pulpitis Unknown status NCT02940405 Not Applicable Ketorolac Tromethamine;Placebo
47 Assessment of Postoperative Pain Using Reciproc Versus One Shape Files in Patients With Irreversible Pulpitis Unknown status NCT02953912 Not Applicable
48 Post Operative Pain of Root Canal Preparation With Wave One and Neolix in Acute Irreversible Pulpitis Unknown status NCT02952300 Not Applicable
49 Comparison Between Reciproc and Oneshape Systems Unknown status NCT02940782 Not Applicable
50 Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques Unknown status NCT01329874 Not Applicable

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

41
Bone, Monocytes, Lung, Brain, Heart, Lymph Node, Eye

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 354)
# Title Authors Year
1
Buccal infiltration versus inferior alveolar nerve block in mandibular 2<sup>nd</sup> premolars with irreversible pulpitis. ( 29607860 )
2018
2
Is the Use of Dexamethasone Effective in Controlling Pain Associated with Symptomatic Irreversible Pulpitis? A Systematic Review. ( 29571913 )
2018
3
Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. ( 29882110 )
2018
4
Effect of Nonsteroidal Anti-inflammatory Drug as an Oral Premedication on the Anesthetic Success of Inferior Alveolar Nerve Block in Treatment of Irreversible Pulpitis: A Systematic Review with Meta-analysis and Trial Sequential Analysis. ( 29709297 )
2018
5
Oral Ketorolac with Inferior Alveolar Nerve Block for Irreversible Pulpitis: A Systematic Review and Meta-analysis. ( 29875886 )
2018
6
Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal anaesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial. ( 29374995 )
2018
7
Effect of relative head position on the anesthetic efficacy of inferior alveolar nerve block during endodontic treatment of patients with irreversible pulpitis. ( 29556558 )
2018
8
INFLUENCE OF TRICALCIUM SILICATE ON COURSE OF TRAUMATIC PULPITIS. ( 29697396 )
2018
9
The Effect of Photobiomodulation on the Depth of Anesthesia During Endodontic Treatment of Teeth With Symptomatic Irreversible Pulpitis (Double Blind Randomized Clinical Trial). ( 29399304 )
2018
10
Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis. ( 29397003 )
2018
11
The prevalence of dental anxiety and its association with pain and other variables among adult patients with irreversible pulpitis. ( 29879974 )
2018
12
Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis - A systematic review and network meta-analysis of randomized controlled trials. ( 29480930 )
2018
13
Acupuncture seems to result in a higher reduction in pain compared with a single 400 milligram dose of ibuprofen in patients with irreversible pulpitis. ( 29571886 )
2018
14
Effect of chronic stress on capsaicin-induced dental nociception in a model of pulpitis in rats. ( 29073563 )
2018
15
Efficacy of IANB and Gow-Gates Techniques in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective Randomized Double Blind Clinical Study. ( 29707005 )
2018
16
Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. ( 30171777 )
2018
17
Effect of a Combination of Intranasal Ketorolac and Nitrous Oxide on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study. ( 29153730 )
2018
18
Efficacy of Articaine versus Lidocaine in Supplemental Infiltration for Mandibular First versus Second Molars with Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 29397214 )
2018
19
Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( 29577321 )
2018
20
The Effect of Apical Positive and Negative Pressure Irrigation Methods on Postoperative Pain in Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial. ( 29935873 )
2018
21
Effect of Preoperative Corticosteroids in Patients with Symptomatic Pulpitis on Postoperative Pain after Single-visit Root Canal Treatment: A Systematic Review and Meta-analysis. ( 30054100 )
2018
22
There seem to be no important differences in the effects of inferior alveolar nerve block and mental incisal nerve block when treating patients with irreversible pulpitis in mandibular premolars. ( 30119829 )
2018
23
The Effect of Different Irrigation Agitation Techniques on Postoperative Pain in Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial. ( 30144989 )
2018
24
Success Rate of 3 Injection Methods with Articaine for Mandibular First Molars with Symptomatic Irreversible Pulpitis: A CONSORT Randomized Double-blind Clinical Trial. ( 30174101 )
2018
25
A response for Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal aesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial. ( 30175929 )
2018
26
Intraosseous anaesthesia as a primary technique for mandibular posterior teeth with symptomatic irreversible pulpitis. ( 30175933 )
2018
27
Effect of ibuprofen on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A meta-analysis. ( 30295006 )
2018
28
Comparative Molecular Analysis of Gram-Negative Bacteria in Primary Teeth with Irreversible Pulpitis or Periapical Pathology. ( 30345964 )
2018
29
Efficacy of Endo-Ice followed by intrapulpal ice application as an adjunct to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis-a randomized controlled trial. ( 30552589 )
2018
30
Anesthetic Efficacy of Articaine and Ketamine for Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis: A Prospective Randomized Double-Blind Study. ( 29225640 )
2017
31
2% mepivacaine seems to do better than 2%A lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis. ( 28215443 )
2017
32
Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis. ( 28416306 )
2017
33
Comparison of Acupuncture with Ibuprofen for Pain Management in Patients with Symptomatic Irreversible Pulpitis: A Randomized Double-Blind Clinical Trial. ( 29275795 )
2017
34
Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: A multi-center randomized controlled trial. ( 29178761 )
2017
35
Supplementary techniques for pain control during root canal treatment of lower posterior teeth with irreversible pulpitis: A systematic review and meta-analysis. ( 28736921 )
2017
36
Successful pulpal anesthesia for symptomatic irreversible pulpitis. ( 28190451 )
2017
37
Treatment Outcomes of Full Pulpotomy as an Alternative to Tooth Extraction in Molars with Hyperplastic/Irreversible Pulpitis: A Case Report. ( 28512498 )
2017
38
Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. ( 27837343 )
2017
39
Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. ( 28449751 )
2017
40
Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis. ( 28694714 )
2017
41
Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: A systematic review of the literature and meta-analysis. ( 27834417 )
2017
42
The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double-blind placebo-controlled clinical trial. ( 28214370 )
2017
43
Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. ( 29269717 )
2017
44
In Patients With Symptomatic Irreversible Pulpitis, Articaine is 3.6 Times More Efficacious Than Lidocaine in Achieving Anesthetic Success When Used for Supplementary Infiltration After Mandibular Block Anesthesia. ( 28501071 )
2017
45
Effect of different dental burs for experimental induction of pulpitis in mice. ( 28829993 )
2017
46
Anesthetic Efficacy of Gow-Gates Nerve Block, Inferior Alveolar Nerve Block, and Their Combination in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Clinical Trial. ( 29273494 )
2017
47
Pulpotomy, partial pulpectomy, and total pulpectomy reduced pain and thermal and chewing sensitivity in patients with molars with irreversible pulpitis. ( 29054279 )
2017
48
Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 28437508 )
2017
49
Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis. ( 29042940 )
2017
50
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. ( 28279187 )
2017

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 CXCL8 IL1A IL1B IL6 MMP1 TNF
2
Show member pathways
13.2 CXCL8 IL1A IL1B IL6 TNF
3
Show member pathways
12.82 CXCL8 IL1A IL1B IL6 TNF
4
Show member pathways
12.74 CXCL8 IL1A IL1B IL6 TNF
5
Show member pathways
12.68 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.63 IL1A IL1B IL6 TNF
7
Show member pathways
12.54 IL1A IL1B IL6 TNF
8
Show member pathways
12.38 IL1A IL1B IL6 TNF
9
Show member pathways
12.3 CXCL8 IL1B IL6 MMP1 TNF
10
Show member pathways
12.27 CXCL8 IL1A IL1B IL6 TNF
11
Show member pathways
12.23 CXCL8 IL1A IL6 TNF
12
Show member pathways
12.22 CXCL8 IL1A IL1B IL6 TNF
13 12.2 IL1A IL1B IL6 TNF
14
Show member pathways
12.18 IL1A IL1B TNF
15
Show member pathways
12.17 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.17 CXCL8 IL1A IL1B IL6 TNF
17
Show member pathways
12.14 CXCL8 IL1A IL1B MMP1
18
Show member pathways
12.14 IL1B IL6 TNF
19
Show member pathways
12.14 IL1A IL1B TNF
20 12.12 IL6 MMP1 TNF
21 12.12 CXCL8 IL1A IL1B IL6 TNF
22 12.1 CXCL8 IL1A IL6
23 12.03 IL1A IL1B TNF
24
Show member pathways
12.02 CXCL8 IL1A IL1B IL6
25
Show member pathways
12 IL1B IL6 TNF
26 11.99 IL1A IL1B TNF
27
Show member pathways
11.98 IL1B IL6 TNF
28 11.94 CXCL8 IL1A IL1B IL6
29 11.92 IL1B IL6 TNF
30 11.91 CXCL8 IL1A IL1B IL6 TNF
31 11.89 IL1A IL1B IL6 TNF
32 11.87 CXCL8 IL1B IL6 TNF
33 11.85 CXCL8 IL1B TNF
34 11.82 CXCL8 IL1A IL1B IL6
35 11.78 CXCL8 IL6 MMP1
36 11.76 CXCL8 IL1A IL1B IL6 TNF
37 11.73 IL1B IL6 TNF
38 11.71 IL1B IL6 TNF
39 11.69 CXCL8 IL1A IL1B IL6 MMP1 TNF
40 11.66 CXCL8 IL1B IL6 TNF
41 11.6 CXCL8 IL1A IL1B IL6 TNF
42 11.58 CXCL8 IL1B IL6 TNF
43 11.55 CXCL8 IL6 MMP1
44 11.52 IL6 KNG1 TNF
45 11.52 IL1A IL1B IL6
46 11.49 CXCL8 IL1B IL6 TNF
47 11.43 IL1A IL1B IL6 TNF
48 11.39 CXCL8 IL1A IL1B IL6 MMP1 TNF
49 11.36 IL1B IL6 TNF
50 11.36 IL1A IL1B IL6

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CXCL8 IL1A IL1B IL6 KNG1 TNF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP IL1A IL1B IL6 KNG1

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.96 CXCL8 IL1A IL1B IL6
2 positive regulation of gene expression GO:0010628 9.94 IL1A IL1B IL6 TNF
3 positive regulation of apoptotic process GO:0043065 9.91 IL6 KNG1 TNF TRPV1
4 immune response GO:0006955 9.91 CXCL8 IL1A IL1B IL6 TNF
5 leukocyte migration GO:0050900 9.87 IL1B MMP1 TNF
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 IL1B KNG1 TRPV1
7 positive regulation of angiogenesis GO:0045766 9.85 CXCL8 IL1A IL1B
8 regulation of signaling receptor activity GO:0010469 9.85 CXCL8 IL1A IL1B IL6 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B IL6 TNF
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 IL1B IL6 TNF
11 response to glucocorticoid GO:0051384 9.74 IL1B IL6 TNF
12 cellular response to lipopolysaccharide GO:0071222 9.73 CXCL8 IL1B IL6 TNF
13 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B IL6 TNF
14 positive regulation of cytokine secretion GO:0050715 9.69 IL1A TNF
15 positive regulation of interleukin-8 production GO:0032757 9.69 IL1B TNF
16 positive regulation of mitotic nuclear division GO:0045840 9.68 IL1A IL1B
17 positive regulation of vascular endothelial growth factor production GO:0010575 9.68 IL1A IL1B
18 positive regulation of neutrophil chemotaxis GO:0090023 9.68 CXCL8 IL1B
19 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B TNF TRPV1
21 microglial cell activation GO:0001774 9.66 TNF TRPV1
22 embryonic digestive tract development GO:0048566 9.66 CXCL8 TNF
23 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
27 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.63 IL1A IL1B
28 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL8 IL1A IL1B IL6 MMP1 TNF
29 response to carbohydrate GO:0009743 9.62 DSPP IL1B
30 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.6 IL1B TNF
32 ectopic germ cell programmed cell death GO:0035234 9.59 IL1A IL1B
33 interleukin-6 production GO:0032635 9.58 ASH1L IL1B
34 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
35 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.58 IL1A IL1B TNF
36 positive regulation of fever generation GO:0031622 9.56 IL1B TNF
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.54 IL1B TNF
38 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6 TNF
39 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
40 positive regulation of glial cell proliferation GO:0060252 9.5 IL1B IL6 TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IL1B TNF
42 positive regulation of neuroinflammatory response GO:0150078 9.43 IL1B IL6 TNF
43 inflammatory response GO:0006954 9.17 CXCL8 IL1A IL1B IL6 KNG1 TNF
44 fever generation GO:0001660 9.13 IL1A IL1B TRPV1
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 ASH1L IL1A IL1B IL6 TNF

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B

Sources for Pulpitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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