MCID: PLP001
MIFTS: 49

Pulpitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pulpitis

MalaCards integrated aliases for Pulpitis:

Name: Pulpitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11121
ICD10 33 K04.0
ICD9CM 35 522.0
MeSH 44 D011671
NCIt 50 C52595
UMLS 73 C0034103

Summaries for Pulpitis

MalaCards based summary : Pulpitis is related to periapical periodontitis and paine syndrome. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and trigeminal ganglion, and related phenotypes are cardiovascular system and integument

Wikipedia : 76 Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels the nerves and... more...

Related Diseases for Pulpitis

Diseases related to Pulpitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 periapical periodontitis 32.2 DSPP IL1B IL6
2 paine syndrome 29.9 IL1B TRPV1
3 root resorption 29.6 DSPP IL1A IL1B
4 gingivitis 29.1 CXCL8 IL1A IL1B IL6 TNF
5 contact dermatitis 28.9 CXCL8 IL1A IL1B IL6 TNF
6 periodontitis 28.6 CXCL8 IL1A IL1B IL6 MMP1 TNF
7 peptic esophagitis 10.8 CXCL8 IL1B
8 acute transverse myelitis 10.7 CXCL8 IL6
9 opisthorchiasis 10.7 CXCL8 IL1B
10 tungiasis 10.7 CXCL8 TNF
11 denture stomatitis 10.7 CXCL8 IL6
12 papillary conjunctivitis 10.7 CXCL8 IL6
13 systemic onset juvenile idiopathic arthritis 10.7 IL1B TNF
14 staphylococcal toxic shock syndrome 10.7 IL1B TNF
15 autoimmune myocarditis 10.7 IL1B TNF
16 kashin-beck disease 10.7 IL1B TNF
17 uremic pruritus 10.7 IL1B IL6
18 glossitis 10.7 IL1B IL6
19 scorpion envenomation 10.7 IL6 TNF
20 euthyroid sick syndrome 10.7 IL1B IL6
21 vulvar vestibulitis syndrome 10.7 IL1B TNF
22 burns 10.7 IL1B TNF
23 acute monoblastic leukemia 10.7 CXCL8 IL6
24 leukomalacia 10.7 IL6 TNF
25 trichuriasis 10.7 CXCL8 TNF
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
27 ascaris lumbricoides infection 10.7 IL1B IL6
28 cerebral artery occlusion 10.6 IL1B TNF
29 critical limb ischemia 10.6 IL6 TNF
30 capillary leak syndrome 10.6 CXCL8 IL6
31 null-cell leukemia 10.6 IL6 TNF
32 retinitis pigmentosa 55 10.6 IL6 TNF
33 retinitis pigmentosa 60 10.6 IL1B TNF
34 clonorchiasis 10.6 CXCL8 TNF
35 anca-associated vasculitis 10.6 IL6 TNF
36 actinic prurigo 10.6 IL1B TNF
37 mycobacterium abscessus 10.6 CXCL8 TNF
38 posterior urethral valves 10.6 IL6 TNF
39 leukoregulin 10.5 CXCL8 IL1A
40 chronic follicular conjunctivitis 10.5 IL1A IL1B
41 necrotizing fasciitis 10.5 CXCL8 IL6
42 cysticercosis 10.5 IL1B IL6
43 scabies 10.5 CXCL8 IL1A
44 recurrent corneal erosion 10.5 CXCL8 IL1B IL6
45 bagassosis 10.5 CXCL8 IL1B IL6
46 microscopic colitis 10.5 IL6 TNF
47 jejunoileitis 10.5 IL1B TNF
48 funisitis 10.5 CXCL8 IL1B IL6
49 vaginitis 10.5 CXCL8 IL1B IL6
50 listeriosis 10.5 IL6 TNF

Graphical network of the top 20 diseases related to Pulpitis:



Diseases related to Pulpitis

Symptoms & Phenotypes for Pulpitis

MGI Mouse Phenotypes related to Pulpitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 SCN8A TNF TRPV1 ASH1L IL1A IL1B
2 integument MP:0010771 9.43 IL6 TNF TRPV1 ASH1L IL1A IL1B
3 neoplasm MP:0002006 9.1 MMP1 TNF TRPV1 IL1A IL1B IL6

Drugs & Therapeutics for Pulpitis

Drugs for Pulpitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
2
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
4
Mepivacaine Approved, Vet_approved Phase 4,Not Applicable 96-88-8 4062
5
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
6
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
7
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
10
Alprazolam Approved, Illicit, Investigational Phase 4 28981-97-7 2118
11
Ceftibuten Approved, Investigational Phase 4,Not Applicable 97519-39-6 5282241 5282242
12
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Early Phase 1 50-02-2 5743
14
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Not Applicable 69-72-7 338
15
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
16
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
17
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 16682734 105143
18 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
19 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
21 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
22 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Not Applicable
24 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
25 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
26 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Analgesics, Opioid Phase 4,Phase 2,Phase 1
28 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
29 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Mydriatics Phase 4,Phase 3,Phase 2,Not Applicable
33 Narcotics Phase 4,Phase 2,Phase 1
34 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Dexketoprofen trometamol Phase 4
44 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Carticaine Phase 4,Phase 3,Phase 2,Not Applicable
46 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
47 Sodium Channel Blockers Phase 4,Phase 3,Phase 2,Not Applicable
48 Antiemetics Phase 4,Phase 3,Early Phase 1
49 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Early Phase 1
50 Gastrointestinal Agents Phase 4,Phase 3,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
4 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
5 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
6 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
7 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
8 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
9 Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block Completed NCT01546090 Phase 4 Alprazolam;placebo
10 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
11 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
12 Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Not yet recruiting NCT03502135 Phase 4 Tetracaine HCl and oxymetazoline HCl nasal spray
13 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
14 Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain Completed NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
15 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
16 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
17 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
18 Effect of Lidocaine/Dexamethasone on the Success of IANB Completed NCT03531970 Phase 2, Phase 3 2% lidocaine with 1:80,000 epinephrine;Dexamethasone;Placebo
19 Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block Completed NCT02726737 Phase 3 sodium bicarbonate;Lidocaine;sterile distilled water
20 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
21 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
22 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
23 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
24 Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017 Recruiting NCT03488836 Phase 2, Phase 3
25 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques Recruiting NCT02601833 Phase 3
26 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
27 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
28 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
29 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
30 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
31 Reduction of Post-operative Endodontic Pain Completed NCT01480752 Phase 2 Lornoxicam;normal saline;no injection
32 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
33 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
34 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
35 Efficacy of Ketorolac Buccal Infiltration on Success Rate of Inferior Alveolar Nerve Block Completed NCT02536430 Phase 2 Ketorolac Tromethamine;Placebo
36 Efficacy of Two Injection Techniques on Success Rate of Inferior Alveolar Nerve Anesthesia Completed NCT02543619 Phase 2
37 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
38 Effect of High-dose Naloxone Following Third Molar Extraction Recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
39 Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block Active, not recruiting NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
40 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
41 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
42 Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain Not yet recruiting NCT03410212 Phase 2 Ketorolac Tromethamine
43 Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques Unknown status NCT01329874 Not Applicable
44 A Study of the Trigeminal Cardio-Reflex in Endodontic and Other Dental Treatment Unknown status NCT02745782
45 Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars Unknown status NCT00972556 Not Applicable Gray Mineral Trioxide Aggregate (GMTA);Diluted (20%) Formocresol (DFC)
46 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Unknown status NCT02681276 Not Applicable
47 Anesthetic Efficacy of X-tip Intraosseous Injection Unknown status NCT01214369 Not Applicable
48 Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis Completed NCT02422823 Not Applicable Articaine;Articaine;Epinephrine
49 Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis Completed NCT01561183 Not Applicable
50 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280 Not Applicable

Search NIH Clinical Center for Pulpitis

Cochrane evidence based reviews: pulpitis

Genetic Tests for Pulpitis

Anatomical Context for Pulpitis

MalaCards organs/tissues related to Pulpitis:

41
Bone, Testes, Trigeminal Ganglion, Monocytes

Publications for Pulpitis

Articles related to Pulpitis:

(show top 50) (show all 336)
# Title Authors Year
1
Buccal infiltration versus inferior alveolar nerve block in mandibular 2<sup>nd</sup> premolars with irreversible pulpitis. ( 29607860 )
2018
2
Is the Use of Dexamethasone Effective in Controlling Pain Associated with Symptomatic Irreversible Pulpitis? A Systematic Review. ( 29571913 )
2018
3
Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. ( 29882110 )
2018
4
Effect of Nonsteroidal Anti-inflammatory Drug as an Oral Premedication on the Anesthetic Success of Inferior Alveolar Nerve Block in Treatment of Irreversible Pulpitis: A Systematic Review with Meta-analysis and Trial Sequential Analysis. ( 29709297 )
2018
5
Oral Ketorolac with Inferior Alveolar Nerve Block for Irreversible Pulpitis: A Systematic Review and Meta-analysis. ( 29875886 )
2018
6
Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal anaesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial. ( 29374995 )
2018
7
Effect of relative head position on the anesthetic efficacy of inferior alveolar nerve block during endodontic treatment of patients with irreversible pulpitis. ( 29556558 )
2018
8
INFLUENCE OF TRICALCIUM SILICATE ON COURSE OF TRAUMATIC PULPITIS. ( 29697396 )
2018
9
The Effect of Photobiomodulation on the Depth of Anesthesia During Endodontic Treatment of Teeth With Symptomatic Irreversible Pulpitis (Double Blind Randomized Clinical Trial). ( 29399304 )
2018
10
Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis. ( 29397003 )
2018
11
The prevalence of dental anxiety and its association with pain and other variables among adult patients with irreversible pulpitis. ( 29879974 )
2018
12
Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis - A systematic review and network meta-analysis of randomized controlled trials. ( 29480930 )
2018
13
Acupuncture seems to result in a higher reduction in pain compared with a single 400 milligram dose of ibuprofen in patients with irreversible pulpitis. ( 29571886 )
2018
14
Effect of chronic stress on capsaicin-induced dental nociception in a model of pulpitis in rats. ( 29073563 )
2018
15
Efficacy of IANB and Gow-Gates Techniques in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective Randomized Double Blind Clinical Study. ( 29707005 )
2018
16
Efficacy of Articaine versus Lidocaine in Supplemental Infiltration for Mandibular First versus Second Molars with Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 29397214 )
2018
17
The Effect of Apical Positive and Negative Pressure Irrigation Methods on Postoperative Pain in Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial. ( 29935873 )
2018
18
Effect of a Combination of Intranasal Ketorolac and Nitrous Oxide on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study. ( 29153730 )
2018
19
Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( 29577321 )
2018
20
Anesthetic Efficacy of Articaine and Ketamine for Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis: A Prospective Randomized Double-Blind Study. ( 29225640 )
2017
21
2% mepivacaine seems to do better than 2%A lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis. ( 28215443 )
2017
22
Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis. ( 28416306 )
2017
23
Comparison of Acupuncture with Ibuprofen for Pain Management in Patients with Symptomatic Irreversible Pulpitis: A Randomized Double-Blind Clinical Trial. ( 29275795 )
2017
24
Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: A multi-center randomized controlled trial. ( 29178761 )
2017
25
Supplementary techniques for pain control during root canal treatment of lower posterior teeth with irreversible pulpitis: A systematic review and meta-analysis. ( 28736921 )
2017
26
Successful pulpal anesthesia for symptomatic irreversible pulpitis. ( 28190451 )
2017
27
Treatment Outcomes of Full Pulpotomy as an Alternative to Tooth Extraction in Molars with Hyperplastic/Irreversible Pulpitis: A Case Report. ( 28512498 )
2017
28
Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. ( 27837343 )
2017
29
Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. ( 28449751 )
2017
30
Sensitivity, Specificity, Predictive Values, and Accuracy of Three Diagnostic Tests to Predict Inferior Alveolar Nerve Blockade Failure in Symptomatic Irreversible Pulpitis. ( 28694714 )
2017
31
Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: A systematic review of the literature and meta-analysis. ( 27834417 )
2017
32
The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double-blind placebo-controlled clinical trial. ( 28214370 )
2017
33
Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. ( 29269717 )
2017
34
In Patients With Symptomatic Irreversible Pulpitis, Articaine is 3.6 Times More Efficacious Than Lidocaine in Achieving Anesthetic Success When Used for Supplementary Infiltration After Mandibular Block Anesthesia. ( 28501071 )
2017
35
Effect of different dental burs for experimental induction of pulpitis in mice. ( 28829993 )
2017
36
Anesthetic Efficacy of Gow-Gates Nerve Block, Inferior Alveolar Nerve Block, and Their Combination in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective, Randomized Clinical Trial. ( 29273494 )
2017
37
Pulpotomy, partial pulpectomy, and total pulpectomy reduced pain and thermal and chewing sensitivity in patients with molars with irreversible pulpitis. ( 29054279 )
2017
38
Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial. ( 28437508 )
2017
39
Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis. ( 29042940 )
2017
40
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. ( 28279187 )
2017
41
Up-regulation of TLR2 and TLR4 in high mobility group Box1-stimulated macrophages in pulpitis patients. ( 28293399 )
2017
42
Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial. ( 28857203 )
2017
43
Partial Pulpotomy in Mature Permanent Teeth with Clinical Signs Indicative of Irreversible Pulpitis: A Randomized Clinical Trial. ( 28673494 )
2017
44
Efficacy of orally administered prednisolone versus partial endodontic treatment on pain reduction in emergency care of acute irreversible pulpitis of mandibular molars: study protocol for a randomized controlled trial. ( 28351379 )
2017
45
Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. ( 28776717 )
2017
46
The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. ( 28560802 )
2017
47
Combination Analgesics Reduce Postoperative Pain in Teeth With a Pulpal Diagnosis of Irreversible Pulpitis. ( 28259322 )
2017
48
Trigeminocardiac reflex during non-surgical root canal treatment of teeth with irreversible pulpitis. ( 28728750 )
2017
49
Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis. ( 27176631 )
2016
50
Management of Chronic Hyperplastic Pulpitis in Mandibular Molars of Middle Aged Adults- A Multidisciplinary Approach. ( 26894192 )
2016

Variations for Pulpitis

Expression for Pulpitis

Search GEO for disease gene expression data for Pulpitis.

Pathways for Pulpitis

Pathways related to Pulpitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CXCL8 IL1A IL1B IL6 MMP1 TNF
2
Show member pathways
13.19 CXCL8 IL1A IL1B IL6 TNF
3
Show member pathways
12.82 CXCL8 IL1A IL1B IL6 TNF
4
Show member pathways
12.75 CXCL8 IL1A IL1B IL6 TNF
5
Show member pathways
12.67 CXCL8 IL1B IL6 TNF
6
Show member pathways
12.62 IL1A IL1B IL6 TNF
7
Show member pathways
12.6 CXCL8 IL1A IL1B IL6 TNF
8
Show member pathways
12.43 IL1A IL1B TNF
9
Show member pathways
12.4 IL1A IL1B IL6 TNF
10
Show member pathways
12.38 IL1A IL1B IL6 TNF
11
Show member pathways
12.3 CXCL8 IL1B IL6 MMP1 TNF
12
Show member pathways
12.23 CXCL8 IL1A IL6 TNF
13
Show member pathways
12.22 CXCL8 IL1A IL1B IL6 TNF
14 12.2 IL1A IL1B IL6 TNF
15
Show member pathways
12.19 CXCL8 IL1A IL1B IL6 TNF
16
Show member pathways
12.18 IL1B IL6 TNF
17
Show member pathways
12.17 IL1A IL1B TNF
18
Show member pathways
12.16 CXCL8 IL1B IL6 TNF
19
Show member pathways
12.14 IL1B IL6 TNF
20
Show member pathways
12.14 IL1A IL1B TNF
21 12.12 CXCL8 IL1A IL1B IL6 TNF
22 12.11 IL6 MMP1 TNF
23 12.09 CXCL8 IL1A IL6
24 12.02 IL1A IL1B TNF
25
Show member pathways
12.01 CXCL8 IL1A IL1B IL6
26 11.98 IL1A IL1B TNF
27 11.93 CXCL8 IL1A IL1B IL6
28 11.91 CXCL8 IL1A IL1B IL6 TNF
29 11.9 IL1B IL6 TNF
30 11.89 IL1A IL1B IL6 TNF
31 11.87 CXCL8 IL1B IL6 TNF
32 11.84 CXCL8 IL1B TNF
33 11.81 CXCL8 IL1A IL1B IL6
34 11.77 CXCL8 IL6 MMP1
35 11.76 CXCL8 IL1A IL1B IL6 TNF
36 11.72 IL1B IL6 TNF
37 11.69 CXCL8 IL1A IL1B IL6 MMP1 TNF
38 11.66 CXCL8 IL1B IL6 TNF
39 11.6 CXCL8 IL1A IL1B IL6 TNF
40 11.58 CXCL8 IL1B IL6 TNF
41 11.55 CXCL8 IL6 MMP1
42 11.52 IL6 KNG1 TNF
43 11.51 IL1A IL1B IL6
44 11.49 CXCL8 IL1B IL6 TNF
45 11.43 IL1A IL1B IL6 TNF
46 11.39 CXCL8 IL1A IL1B IL6 MMP1 TNF
47 11.36 IL1B IL6 TNF
48 11.35 IL1A IL1B IL6
49 11.34 CXCL8 IL6 MMP1
50 11.34 CXCL8 IL1A IL1B IL6 TNF

GO Terms for Pulpitis

Cellular components related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CXCL8 IL1A IL1B IL6 KNG1 TNF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP IL1A IL1B IL6 KNG1

Biological processes related to Pulpitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.93 CXCL8 IL1A IL1B IL6
2 positive regulation of gene expression GO:0010628 9.91 IL1A IL1B IL6 TNF
3 positive regulation of apoptotic process GO:0043065 9.88 IL6 KNG1 TNF TRPV1
4 immune response GO:0006955 9.85 CXCL8 IL1A IL1B IL6 TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 IL1A IL1B TNF
6 regulation of signaling receptor activity GO:0010469 9.83 CXCL8 IL1A IL1B IL6 TNF
7 positive regulation of angiogenesis GO:0045766 9.82 CXCL8 IL1A IL1B
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B IL6 TNF
9 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 IL6 TNF
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.78 IL1B IL6 TNF
11 positive regulation of JNK cascade GO:0046330 9.69 IL1A IL1B TNF
12 positive regulation of cytokine secretion GO:0050715 9.68 IL1A TNF
13 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TNF
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.67 IL1A IL1B
15 positive regulation of mitotic nuclear division GO:0045840 9.67 IL1A IL1B
16 positive regulation of leukocyte chemotaxis GO:0002690 9.66 CXCL8 IL6
17 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
18 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
19 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL8 IL1A IL1B IL6 MMP1 TNF
20 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
22 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.6 IL1A IL1B
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL1B TNF
24 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.58 IL1A IL1B
25 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
27 positive regulation of interleukin-6 production GO:0032755 9.56 IL1A IL1B IL6 TNF
28 ectopic germ cell programmed cell death GO:0035234 9.55 IL1A IL1B
29 interleukin-6 production GO:0032635 9.54 ASH1L IL1B
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IL1B TNF TRPV1
31 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.5 IL1A IL1B TNF
33 positive regulation of fever generation GO:0031622 9.49 IL1B TNF
34 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
36 inflammatory response GO:0006954 9.17 CXCL8 IL1A IL1B IL6 KNG1 TNF
37 fever generation GO:0001660 9.13 IL1A IL1B TRPV1
38 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 ASH1L IL1A IL1B IL6 TNF

Molecular functions related to Pulpitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B

Sources for Pulpitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....