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MCID: PNC012
MIFTS: 30

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

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MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Punctate Keratitis 12 73
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratitis 12
Punctate Epithelial Keratitis 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12197
ICD10 33 H16.14
ICD9CM 35 370.21
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Summaries for Punctate Epithelial Keratoconjunctivitis

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MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as punctate keratitis, is related to entropion and heart block, congenital. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Dexamethasone and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye.

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Related Diseases for Punctate Epithelial Keratoconjunctivitis

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Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 entropion 10.8 DRD5 SRCIN1
2 heart block, congenital 10.6 TNFRSF25 TRIM21
3 diffuse scleroderma 10.6 TNFRSF25 TRIM21
4 sclerosing keratitis 10.5 B2M SRCIN1
5 paraphimosis 10.4 KANTR SRCIN1
6 exposure keratitis 10.2 DRD5 KANTR
7 visual agnosia 10.2 KANTR PSEN2
8 facial hemiatrophy 10.2 KANTR TRIM21
9 cranio-facial dystonia 10.1 DRD5 KANTR
10 oculogyric crisis 10.0 B2M KANTR
11 superficial keratitis 10.0 DHH IFNA2 PRPF6 SRCIN1 TNFRSF25
12 adie pupil 10.0 KANTR TNFRSF25 TRIM21
13 lymphedema, hereditary, ii 9.9 DRD5 KANTR
14 corneal dystrophy, thiel-behnke type 9.9
15 diarrhea 5, with tufting enteropathy, congenital 9.9
16 dry eye syndrome 9.9
17 shipyard eye 9.9
18 corneal dystrophy 9.9
19 keratoconjunctivitis 9.9
20 anterior scleritis 9.8 B2M SRCIN1
21 functional colonic disease 9.8 B2M KANTR
22 intraocular retinoblastoma 9.5 KANTR MLX

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis
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Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

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Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

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Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
4
Pseudoephedrine Approved Phase 4 90-82-4 7028
5 Anti-Infective Agents Phase 4,Not Applicable
6 Ophthalmic Solutions Phase 4,Not Applicable
7 Pharmaceutical Solutions Phase 4,Not Applicable
8 Antiemetics Phase 4
9 Antifungal Agents Phase 4,Not Applicable
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Antirheumatic Agents Phase 4,Not Applicable
13 Autonomic Agents Phase 4
14 BB 1101 Phase 4
15 Calcineurin Inhibitors Phase 4,Not Applicable
16 Cyclosporins Phase 4,Not Applicable
17 Dermatologic Agents Phase 4,Not Applicable
18 Dexamethasone acetate Phase 4 1177-87-3
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 HIV Protease Inhibitors Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 Immunosuppressive Agents Phase 4,Not Applicable
26 Nasal Decongestants Phase 4
27 Peripheral Nervous System Agents Phase 4
28
protease inhibitors Phase 4
29 Respiratory System Agents Phase 4
30 Tetrahydrozoline Phase 4,Not Applicable
31 Vasoconstrictor Agents Phase 4
32
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
33 Estradiol valerate Approved, Investigational, Vet_approved Not Applicable 979-32-8
34
Ethinyl Estradiol Approved Not Applicable 57-63-6 5991
35
Gatifloxacin Approved, Investigational Not Applicable 112811-59-3 5379
36
Moxifloxacin Approved, Investigational Not Applicable 354812-41-2, 151096-09-2 152946
37
Norgestimate Approved, Investigational Not Applicable 35189-28-7 6540478
38
Polyestradiol phosphate Approved Not Applicable 28014-46-2
39 Anti-Bacterial Agents Not Applicable
40 Contraceptive Agents Not Applicable
41 Contraceptives, Oral Not Applicable
42 Contraceptives, Oral, Combined Not Applicable
43 Estradiol 17 beta-cypionate Not Applicable
44 Estradiol 3-benzoate Not Applicable
45 Fluoroquinolones Not Applicable
46 Mitomycins Not Applicable
47 Norgestimate, ethinyl estradiol drug combination Not Applicable
48 Nucleic Acid Synthesis Inhibitors Not Applicable
49 Topoisomerase Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101 Unknown status NCT02656394 Phase 2 GL101;Placebo
3 Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca Completed NCT00349466 Phase 2 CF101;Placebo
4 Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision Unknown status NCT00892918 Not Applicable Moxifloxacin ophthalmic solution 0.5% ; Gatifloxacin ophthalmic solution 0.3%
5 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

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Genetic Tests for Punctate Epithelial Keratoconjunctivitis

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Anatomical Context for Punctate Epithelial Keratoconjunctivitis

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MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

41
Eye
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Publications for Punctate Epithelial Keratoconjunctivitis

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Articles related to Punctate Epithelial Keratoconjunctivitis:

# Title Authors Year
1
Epidemic Keratoconjunctivitis: (Superficial Punctate Keratitis, Keratitis Subepithelialis, Keratitis Maculosa, Keratitis Nummularis) With a Review of the Literature and a Report of 125A Cases. ( 29793576 )
2018
2
Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp. ( 27124778 )
2016
3
Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis. ( 24240881 )
2013
4
Thygeson superficial punctate keratitis and scarring. ( 22495026 )
2012
5
Superficial punctate keratitis and conjunctival erosions associated with congenital tufting enteropathy. ( 20447614 )
2010
6
Disappearance of honeycomb opacity of Thiel-Behnke corneal dystrophy after Thygeson superficial punctate keratitis. ( 16227859 )
2005
7
The use of placental extract in the treatment of herpetic keratitis and superficial punctate keratitis. ( 18878075 )
1948
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Variations for Punctate Epithelial Keratoconjunctivitis

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Expression for Punctate Epithelial Keratoconjunctivitis

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Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.
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Pathways for Punctate Epithelial Keratoconjunctivitis

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Pathways related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dendritic Cells Developmental Lineage Pathway 65
10.67 CD1A EPCAM IFNA2
2
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.32 CST3 PSEN2
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GO Terms for Punctate Epithelial Keratoconjunctivitis

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Cellular components related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 CST3 PSEN2 SLC6A1 SRCIN1

Biological processes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.13 CST3 SLC6A1 TAT
2 response to estradiol GO:0032355 8.8 CST3 DHH SLC6A1
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Sources for Punctate Epithelial Keratoconjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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