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MCID: PNC012
MIFTS: 33

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

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MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Punctate Keratitis 12 74
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratitis 12
Punctate Epithelial Keratitis 74

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12197
ICD9CM 36 370.21
SNOMED-CT 69 42513006
ICD10 34 H16.14
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Summaries for Punctate Epithelial Keratoconjunctivitis

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MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as punctate keratitis, is related to thygeson superficial punctate keratopathy and keratitis, hereditary. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Interferon gamma signaling and Dendritic Cells Developmental Lineage Pathway. The drugs Dexamethasone and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, colon and heart.

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Related Diseases for Punctate Epithelial Keratoconjunctivitis

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Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 thygeson superficial punctate keratopathy 11.3
2 keratitis, hereditary 10.6
3 heart block, congenital 10.3 TNFRSF25 TRIM21
4 diffuse scleroderma 10.3 TNFRSF25 TRIM21
5 sclerosing keratitis 10.3 B2M SRCIN1
6 idiopathic inflammatory myopathy 10.3 HLA-DRB1 TRIM21
7 herpangina 10.3 IFNA2 TNFRSF25
8 discoid lupus erythematosus 10.2 HLA-DRB1 IFNA2
9 senile ectropion 10.2 KANTR SRCIN1
10 al amyloidosis 10.2 B2M CST3
11 paraphimosis 10.2 KANTR SRCIN1
12 facial hemiatrophy 10.2 KANTR TRIM21
13 keratoconjunctivitis 10.1
14 visual agnosia 10.1 KANTR PSEN2
15 subclavian steal syndrome 10.1 CD1A KANTR
16 anteroseptal myocardial infarction 10.1 HLA-DRB1 KANTR
17 adie pupil 10.1 KANTR TNFRSF25 TRIM21
18 acute retrobulbar neuritis 10.1 B2M TRIM21
19 superficial keratitis 10.0 DHH IFNA2 PRPF6 SRCIN1 TNFRSF25
20 oculogyric crisis 10.0 B2M KANTR
21 corneal dystrophy, thiel-behnke type 10.0
22 diarrhea 5, with tufting enteropathy, congenital 10.0
23 dry eye syndrome 10.0
24 myopia 10.0
25 shipyard eye 10.0
26 corneal dystrophy 10.0
27 conjunctivitis 10.0
28 ovarian cystic teratoma 10.0 B2M IFNA2
29 functional colonic disease 10.0 B2M KANTR
30 anterior scleritis 9.9 B2M SRCIN1
31 intraocular retinoblastoma 9.7 KANTR MLX

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis
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Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

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Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

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Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4 Anti-Infective Agents Phase 4,Not Applicable
5 Pharmaceutical Solutions Phase 4,Not Applicable
6 Ophthalmic Solutions Phase 4,Not Applicable
7 Antineoplastic Agents, Hormonal Phase 4
8 HIV Protease Inhibitors Phase 4
9
protease inhibitors Phase 4
10 Dermatologic Agents Phase 4,Not Applicable
11 BB 1101 Phase 4
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
13 Antifungal Agents Phase 4,Not Applicable
14 Hormone Antagonists Phase 4
15 Hormones Phase 4
16 Antiemetics Phase 4
17 Gastrointestinal Agents Phase 4
18 glucocorticoids Phase 4
19 Calcineurin Inhibitors Phase 4,Not Applicable
20 Autonomic Agents Phase 4
21 Immunologic Factors Phase 4,Not Applicable
22 Immunosuppressive Agents Phase 4,Not Applicable
23 Antirheumatic Agents Phase 4,Not Applicable
24 Peripheral Nervous System Agents Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Cyclosporins Phase 4,Not Applicable
27
Ethinyl Estradiol Approved Not Applicable 57-63-6 5991
28
Gatifloxacin Approved, Investigational Not Applicable 112811-59-3 5379
29
Polyestradiol phosphate Approved Not Applicable 28014-46-2
30
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
31
Norgestimate Approved, Investigational Not Applicable 35189-28-7 6540478
32
Moxifloxacin Approved, Investigational Not Applicable 354812-41-2, 151096-09-2 152946
33 Norgestimate, ethinyl estradiol drug combination Not Applicable
34 Contraceptives, Oral, Combined Not Applicable
35 Contraceptives, Oral Not Applicable
36 Estradiol 3-benzoate Not Applicable
37 Contraceptive Agents Not Applicable
38 Topoisomerase Inhibitors Not Applicable
39 Estradiol 17 beta-cypionate Not Applicable
40 Mitomycins Not Applicable
41 Anti-Bacterial Agents Not Applicable
42 Lubricant Eye Drops

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101 Unknown status NCT02656394 Phase 2 GL101;Placebo
3 Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca Completed NCT00349466 Phase 2 CF101;Placebo
4 Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision Unknown status NCT00892918 Not Applicable Moxifloxacin ophthalmic solution 0.5% ; Gatifloxacin ophthalmic solution 0.3%
5 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
6 DRy Eye Outcome and Prescription Study Recruiting NCT03652415

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

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Genetic Tests for Punctate Epithelial Keratoconjunctivitis

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Anatomical Context for Punctate Epithelial Keratoconjunctivitis

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MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

42
Eye, Colon, Heart
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Publications for Punctate Epithelial Keratoconjunctivitis

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Articles related to Punctate Epithelial Keratoconjunctivitis:

(show top 50) (show all 70)
# Title Authors Year
1
Epidemic Keratoconjunctivitis: (Superficial Punctate Keratitis, Keratitis Subepithelialis, Keratitis Maculosa, Keratitis Nummularis) With a Review of the Literature and a Report of 125 Cases. ( 29793576 )
2018
2
Punctate epithelial keratoconjunctivitis: A microsporidial infestation. ( 30127158 )
2018
3
Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp. ( 27124778 )
2016
4
Effect of Switching to Travoprost Preserved With SofZia in Glaucoma Patients With Chronic Superficial Punctate Keratitis While Receiving BAK-preserved Latanoprost. ( 25967526 )
2016
5
Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis. ( 24240881 )
2015
6
Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. ( 26133248 )
2015
7
Automated Grading System for Evaluation of Superficial Punctate Keratitis Associated With Dry Eye. ( 26066593 )
2015
8
Unilateral punctate keratitis secondary to Wallenberg Syndrome. ( 24882965 )
2014
9
Laser confocal microscopy findings of Thygeson superficial punctate keratitis. ( 24451976 )
2014
10
Thygeson superficial punctate keratitis and scarring. ( 22495026 )
2012
11
In vivo laser confocal microscopy findings of Thygeson superficial punctate keratitis. ( 21562457 )
2011
12
Superficial punctate keratitis and conjunctival erosions associated with congenital tufting enteropathy. ( 20447614 )
2010
13
The role of benzalkonium chloride in the occurrence of punctate keratitis: a meta-analysis of randomized, controlled clinical trials. ( 21119099 )
2010
14
In vivo observation of Langerhans cells by laser confocal microscopy in Thygeson's superficial punctate keratitis. ( 19649162 )
2009
15
Long-term topical cyclosporin A therapy in Thygeson's superficial punctate keratitis: a case report. ( 19105827 )
2008
16
Diagnosis and management of Thygeson's superficial punctate keratitis. ( 17601570 )
2007
17
Diffuse punctate keratitis in a patient treated with cetuximab as monotherapy. ( 17442661 )
2007
18
The role of common viral ocular pathogens in Thygeson's superficial punctate keratitis. ( 17389746 )
2007
19
Disappearance of honeycomb opacity of Thiel-Behnke corneal dystrophy after Thygeson superficial punctate keratitis. ( 16227859 )
2005
20
Thygeson's superficial punctate keratitis: ten years' experience. ( 14711711 )
2004
21
PCR for varicella zoster virus genome negative in corneal epithelial cells of patients with Thygeson's superficial punctate keratitis. ( 15004582 )
2004
22
Corneal surface changes in Thygeson's superficial punctate keratitis: a clinical and non-contact photomicrographic in vivo study in the human cornea. ( 15134103 )
2004
23
In vivo confocal microscopy of Thygeson's superficial punctate keratitis. ( 15180847 )
2004
24
Thygeson's superficial punctate keratitis recurrence after laser in situ keratomileusis. ( 15364251 )
2004
25
Dry eyes and superficial punctate keratitis: a complication of treatment of glabelar dynamic rhytides with botulinum exotoxin A. ( 15606828 )
2004
26
Recurrence of Thygeson's superficial punctate keratitis after photorefractive keratectomy. ( 12352102 )
2002
27
Photorefractive keratectomy for myopia in the setting of Thygeson's superficial punctate keratitis. ( 11333334 )
2001
28
Topical cyclosporin A in Thygeson's superficial punctate keratitis. ( 9987626 )
1999
29
Superficial punctate keratitis of thygeson: the longest course on record? ( 10571306 )
1999
30
Effect of topical cyclosporin A on Thygeson's superficial punctate keratitis. ( 9550347 )
1996
31
A classical case of Thygeson's superficial punctate keratitis. ( 7619463 )
1995
32
Handling punctate keratitis resulting from systemic cytarabine. ( 8239322 )
1993
33
Superficial punctate keratitis and corneal abrasion due to amantadine hydrochloride. ( 8336180 )
1993
34
Persistent superficial punctate keratitis after resolution of chlamydial follicular conjunctivitis. ( 1424659 )
1992
35
Effect of diethylcarbamazine citrate and anti-inflammatory drugs on experimental onchocercal punctate keratitis. ( 2443887 )
1987
36
Punctate keratitis induced by subconjunctivally injected microfilariae of Onchocerca lienalis. ( 3718315 )
1986
37
Thygeson's superficial punctate keratitis. ( 3994215 )
1985
38
Effect of topical trifluridine on Thygeson's superficial punctate keratitis. ( 6440070 )
1984
39
The differential diagnosis of superficial punctate keratitis. ( 6724823 )
1984
40
Superficial punctate keratitis of Thygeson. ( 7153449 )
1982
41
Thygeson's superficial punctate keratitis. ( 6264365 )
1981
42
HLA DR3 in Thygeson's superficial punctate keratitis. ( 6950542 )
1981
43
Thygeson's superficial punctate keratitis: natural history and association with HLA DR3. ( 7043867 )
1981
44
Management of Thygeson's superficial punctate keratitis. ( 6892542 )
1980
45
Superficial punctate keratitis of Thygeson associated with scarring and Salzmann's nodular degeneration. ( 434089 )
1979
46
Viral isolate in superficial punctate keratitis. ( 4357790 )
1974
47
Morphology of experimental vaccinial superficial punctate keratitis--a scanning and transmission electron microscopic study. ( 5104475 )
1971
48
Superficial punctate keratitis. ( 5164927 )
1971
49
Clinical and laboratory observations on superficial punctate keratitis. ( 5938018 )
1966
50
THYGESON'S SUPERFICIAL PUNCTATE KERATITIS. ( 14123149 )
1963
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Variations for Punctate Epithelial Keratoconjunctivitis

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Expression for Punctate Epithelial Keratoconjunctivitis

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Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.
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Pathways for Punctate Epithelial Keratoconjunctivitis

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Pathways related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Interferon gamma signaling 67
Show member pathways
 11.75 B2M HLA-DRB1 IFNA2 TRIM21
2
Dendritic Cells Developmental Lineage Pathway 66
10.67 CD1A EPCAM IFNA2
3
A-beta Pathways: Plaque Formation and APP Metabolism 66
10.52 CST3 PSEN2
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GO Terms for Punctate Epithelial Keratoconjunctivitis

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Biological processes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell mediated cytotoxicity GO:0001916 8.96 B2M CD1A
2 interferon-gamma-mediated signaling pathway GO:0060333 8.8 B2M HLA-DRB1 TRIM21
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Sources for Punctate Epithelial Keratoconjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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