MCID: PNC012
MIFTS: 30

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases

Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Punctate Keratitis 12 72
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratitis 12
Punctate Epithelial Keratitis 72

Classifications:



External Ids:

Disease Ontology 12 DOID:12197
ICD9CM 35 370.21
SNOMED-CT 68 42513006
ICD10 33 H16.14
UMLS 72 C0259799 C1562761

Summaries for Punctate Epithelial Keratoconjunctivitis

MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as punctate keratitis, is related to superficial keratitis and keratitis, hereditary. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Interferon gamma signaling and A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Hyaluronic acid and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and liver.

Related Diseases for Punctate Epithelial Keratoconjunctivitis

Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 superficial keratitis 30.2 TNFRSF25 SRCIN1 PRPF6 IFNA2 DHH
2 keratitis, hereditary 11.0
3 herpangina 10.5 TNFRSF25 IFNA2
4 adie pupil 10.4 TRIM21 TNFRSF25
5 diffuse scleroderma 10.4 TRIM21 TNFRSF25
6 heart block, congenital 10.4 TRIM21 TNFRSF25
7 discoid lupus erythematosus 10.4 IFNA2 HLA-DRB1
8 idiopathic inflammatory myopathy 10.3 TRIM21 HLA-DRB1
9 sclerosing keratitis 10.3 SRCIN1 B2M
10 conjunctivitis 10.3
11 chickenpox 10.3
12 conjunctival disease 10.3 PSEN2 IFNA2
13 anterior scleritis 10.2 SRCIN1 B2M
14 ocular hypertension 10.2
15 ovarian cystic teratoma 10.2 IFNA2 B2M
16 keratoconjunctivitis 10.1
17 acute retrobulbar neuritis 10.1 TRIM21 B2M
18 focal epithelial hyperplasia 10.1 IFNA2 HLA-DRB1
19 al amyloidosis 10.1 CST3 B2M
20 corneal dystrophy, band-shaped 10.0
21 corneal dystrophy, thiel-behnke type 10.0
22 intraocular pressure quantitative trait locus 10.0
23 diarrhea 5, with tufting enteropathy, congenital 10.0
24 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
25 dry eye syndrome 10.0
26 open-angle glaucoma 10.0
27 chlamydia 10.0
28 corneal neovascularization 10.0
29 onchocerciasis 10.0
30 myopia 10.0
31 paralytic lagophthalmos 10.0
32 lagophthalmos 10.0
33 shipyard eye 10.0
34 diarrhea 10.0
35 inclusion conjunctivitis 10.0
36 keratopathy 10.0
37 corneal dystrophy 10.0
38 corneal ulcer 10.0
39 herpes zoster 10.0
40 herpes simplex 10.0
41 steroid-induced glaucoma 10.0
42 herpes zoster ophthalmicus 10.0
43 vernal conjunctivitis 10.0 CMA1 B2M
44 dengue shock syndrome 10.0 HLA-DRB1 CMA1
45 acute kidney tubular necrosis 10.0 CST3 B2M
46 chilblain lupus 1 9.9 TRIM21 TNFRSF25

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis

Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
2 Ophthalmic Solutions Phase 3
3 Adjuvants, Immunologic Phase 3
4 Immunologic Factors Phase 3
5 Protective Agents Phase 3
6 Viscosupplements Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Multicenter, Randomized, Double-Masked Study of Safety and Efficacy of Vismed® in Dry Eye Syndrome Completed NCT00599716 Phase 3 sodium hyaluronate;vehicle

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Loteprednol
Prednisolone

Genetic Tests for Punctate Epithelial Keratoconjunctivitis

Anatomical Context for Punctate Epithelial Keratoconjunctivitis

MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

41
Eye, Thyroid, Liver, Skin, Bone, Lymph Node, Breast

Publications for Punctate Epithelial Keratoconjunctivitis

Articles related to Punctate Epithelial Keratoconjunctivitis:

(show top 50) (show all 359)
# Title Authors PMID Year
1
False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings. 38
31109479 2019
2
Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats. 38
30947566 2019
3
Chlamydia trachomatis presenting as preseptal cellulitis in a 3-year-old girl. 38
31112775 2019
4
Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. 38
29549486 2019
5
Multimodal Assessment of Corneal Erosions Using Optical Coherence Tomography and Automated Grading of Fluorescein Staining in a Rabbit Dry Eye Model. 38
30834175 2019
6
Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review. 38
31354236 2019
7
Application of botulinum toxin in Horner's muscle for the treatment of dry eye. 38
30001848 2018
8
In Vivo Confocal Microscopy Analysis of the Corneal Layers in Adenoviral Epidemic Keratoconjunctivitis 38
30605932 2018
9
Adjunctive role of self-retained cryopreserved amniotic membrane in treating immune-related dry eye disease. 38
29101724 2018
10
Punctate epithelial keratoconjunctivitis: A microsporidial infestation. 38
30127158 2018
11
Significant correlation between meibomian gland dysfunction and keratitis in young patients with Demodex brevis infestation. 38
29055903 2018
12
Epidemic Keratoconjunctivitis: (Superficial Punctate Keratitis, Keratitis Subepithelialis, Keratitis Maculosa, Keratitis Nummularis) With a Review of the Literature and a Report of 125 Cases. 38
29793576 2018
13
On-eye breakage and recovery of mini-scleral contact lens without compromise for the ocular surface. 38
29248315 2018
14
Evaluation of a multifunctional femtosecond laser for the creation of laser in situ keratomileusis flaps. 38
29703284 2018
15
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin. 38
29494606 2018
16
Real-life results of switching from preserved to preservative-free artificial tears containing hyaluronate in patients with dry eye disease. 38
30197497 2018
17
Ciliopathy: Sjögren-Larsson Syndrome. 38
30578509 2018
18
Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops. 38
29682341 2018
19
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. 38
29670328 2018
20
Treatment of adenoviral keratoconjunctivitis with a combination of povidone-iodine 1.0% and dexamethasone 0.1% drops: a clinical prospective controlled randomized study. 38
28342227 2017
21
One-year efficacy of adjunctive use of Ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy. 38
28711991 2017
22
Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors. 38
28440955 2017
23
Comparison of Safety and Efficacy of Botox and Neuronox in the Management of Benign Essential Blepharospasm: A Split-face Study. 38
29022290 2017
24
[Role of Köllner-Hughes tarsoconjunctival flap in the reconstruction of large eyelid defects]. 38
28478019 2017
25
Graves' Ophthalmopathy in a Paediatric Population. 38
28329893 2017
26
Outcome of the Modified Hughes Procedure for Eyelid Sebaceous Carcinoma. 38
30080002 2017
27
Autologous Platelet-Rich Plasma Eye Drops for the Treatment of Post-LASIK Chronic Ocular Surface Syndrome. 38
29379652 2017
28
Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area. 38
28300740 2017
29
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 38
26895272 2016
30
Prospective Observational Post-marketing Study of Tafluprost 0.0015%/Timolol 0.5% Combination Ophthalmic Solution for Glaucoma and Ocular Hypertension: Short-Term Efficacy and Safety. 38
27492380 2016
31
Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors. 38
27296769 2016
32
Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp. 38
27124778 2016
33
Effect of Switching to Travoprost Preserved With SofZia in Glaucoma Patients With Chronic Superficial Punctate Keratitis While Receiving BAK-preserved Latanoprost. 38
25967526 2016
34
Improvement of Subjective Symptoms and Eye Complications When Changing From 2-Week Frequent Replacement to Daily Disposable Contact Lenses in a Subscriber Membership System. 38
25996420 2016
35
Blepharokeratoconjunctivitis in childhood: corneal involvement and visual outcome. 38
26634709 2016
36
[Safety of the automated microkeratome for Sub-Bowman's Keratomileusis on the flat cornea]. 38
26549141 2016
37
Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy. 38
27032098 2016
38
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis. 38
26771164 2016
39
The use of autologous serum for the treatment of ocular surface disease at a Swedish tertiary referral center. 38
27042143 2016
40
Evaluation of the Effect of Latanoprostene Bunod Ophthalmic Solution, 0.024% in Lowering Intraocular Pressure over 24 h in Healthy Japanese Subjects. 38
26563323 2015
41
Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. 38
26133248 2015
42
Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis. 38
24240881 2015
43
Bimatoprost 0.03% for the Treatment of Eyelash Hypotrichosis: A Pooled Safety Analysis of Six Randomized, Double-masked Clinical Trials. 38
26203317 2015
44
From benzalkonium chloride-preserved Latanoprost to Polyquad-preserved Travoprost: a 6-month study on ocular surface safety and tolerability. 38
25759110 2015
45
Safety and Efficacy of Bimatoprost for Eyelash Growth in Postchemotherapy Subjects. 38
26060513 2015
46
Automated Grading System for Evaluation of Superficial Punctate Keratitis Associated With Dry Eye. 38
26066593 2015
47
Besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial keratitis: a retrospective safety surveillance study. 38
25409447 2015
48
[Clinical analyses of 21 cases of Thygeson's superficial punctate keratitis]. 38
26268638 2015
49
Twenty-four-hour intraocular pressure patterns in patients with thyroid eye disease. 38
25132194 2015
50
Virological and epidemiological analysis of coxsackievirus A24 variant epidemic of acute hemorrhagic conjunctivitis in Okinawa, Japan, in 2011. 38
26109843 2015

Variations for Punctate Epithelial Keratoconjunctivitis

Expression for Punctate Epithelial Keratoconjunctivitis

Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.

Pathways for Punctate Epithelial Keratoconjunctivitis

Pathways related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.42 TRIM21 IFNA2 HLA-DRB1 B2M
2 10.32 PSEN2 CST3

GO Terms for Punctate Epithelial Keratoconjunctivitis

Biological processes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 8.8 TRIM21 HLA-DRB1 B2M

Sources for Punctate Epithelial Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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