MCID: PNC012
MIFTS: 30

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases

Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Punctate Keratitis 12 71
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratitis 12
Punctate Epithelial Keratitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12197
ICD9CM 34 370.21
SNOMED-CT 67 42513006
ICD10 32 H16.14
UMLS 71 C0259799 C1562761

Summaries for Punctate Epithelial Keratoconjunctivitis

MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as punctate keratitis, is related to dry eye syndrome and superficial keratitis. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hyaluronic acid and Viscosupplements have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and thyroid.

Related Diseases for Punctate Epithelial Keratoconjunctivitis

Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 dry eye syndrome 29.5 P2RY2 NGF EGF
2 superficial keratitis 28.8 TENT5D TAC1 SRCIN1 SBK1 PTGFR NGF
3 keratitis, hereditary 11.0
4 prurigo nodularis 10.3 TAC1 NGF
5 conjunctivitis 10.3
6 chickenpox 10.3
7 serotonin syndrome 10.3 TAC1 IFNA2
8 detrusor sphincter dyssynergia 10.3 TAC1 NGF
9 cough variant asthma 10.3 TAC1 NGF
10 ocular hyperemia 10.3 PTGFR EVC2
11 chronic cystitis 10.2 TAC1 NGF
12 trigeminal nerve disease 10.2 TAC1 NGF
13 mononeuropathy 10.2 TAC1 NGF
14 senile ectropion 10.2 SRCIN1 MUC16
15 polyradiculopathy 10.2 TAC1 NGF
16 nerve compression syndrome 10.2 TAC1 NGF
17 ocular hypertension 10.2
18 burning mouth syndrome 10.2 TAC1 NGF
19 keratoconjunctivitis 10.1
20 neurogenic bladder 10.1 TAC1 NGF
21 eyelid disease 10.1 SRCIN1 MUC16
22 lumbosacral plexus lesion 10.1 NGF CNTF
23 corneal dystrophy, band-shaped 10.0
24 corneal dystrophy, thiel-behnke type 10.0
25 intraocular pressure quantitative trait locus 10.0
26 diarrhea 5, with tufting enteropathy, congenital 10.0
27 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
28 open-angle glaucoma 10.0
29 chlamydia 10.0
30 corneal neovascularization 10.0
31 onchocerciasis 10.0
32 myopia 10.0
33 paralytic lagophthalmos 10.0
34 lagophthalmos 10.0
35 shipyard eye 10.0
36 diarrhea 10.0
37 inclusion conjunctivitis 10.0
38 keratopathy 10.0
39 corneal dystrophy 10.0
40 corneal ulcer 10.0
41 herpes zoster 10.0
42 herpes simplex 10.0
43 steroid-induced glaucoma 10.0
44 herpes zoster ophthalmicus 10.0
45 autonomic nervous system disease 10.0 TAC1 NGF
46 paine syndrome 9.9 TAC1 NGF
47 interstitial cystitis 9.9 TAC1 NGF EGF
48 chronic ulcer of skin 9.9 NGF EGF
49 cystitis 9.9 TAC1 NGF EGF
50 sensory peripheral neuropathy 9.9 TAC1 NGF CNTF

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis

Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
2 Viscosupplements Phase 3
3 Adjuvants, Immunologic Phase 3
4 Protective Agents Phase 3
5 Ophthalmic Solutions Phase 3
6 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Multicenter, Randomized, Double-Masked Study of Safety and Efficacy of Vismed® in Dry Eye Syndrome Completed NCT00599716 Phase 3 sodium hyaluronate;vehicle

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

Genetic Tests for Punctate Epithelial Keratoconjunctivitis

Anatomical Context for Punctate Epithelial Keratoconjunctivitis

MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

40
Eye, Skin, Thyroid, Bone, Lymph Node, Liver, Breast

Publications for Punctate Epithelial Keratoconjunctivitis

Articles related to Punctate Epithelial Keratoconjunctivitis:

(show top 50) (show all 364)
# Title Authors PMID Year
1
Dry Eye: The Effect of Chi-Ju-Di-Huang-Wan Plus Si Wu Tang and the Underlying Mechanism. 61
31651183 2020
2
Topical Tacrolimus in Thygeson Superficial Punctate Keratitis. 61
31842035 2019
3
Recurrent herpes zoster ophthalmicus in a young, healthy individual taking high doses of l-Arginine. 61
31497676 2019
4
Comparison of Safety and Efficacy of Botox and Neuronox in the Management of Benign Essential Blepharospasm: A Split-face Study. 61
31612653 2019
5
Chlamydia trachomatis presenting as preseptal cellulitis in a 3-year-old girl. 61
31112775 2019
6
False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings. 61
31109479 2019
7
Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats. 61
30947566 2019
8
Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. 61
29549486 2019
9
Multimodal Assessment of Corneal Erosions Using Optical Coherence Tomography and Automated Grading of Fluorescein Staining in a Rabbit Dry Eye Model. 61
30834175 2019
10
Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review. 61
31354236 2019
11
Maximum Medical Therapy: Brinzolamide/Brimonidine And Travoprost/Timolol Fixed-Dose Combinations In Glaucoma And Ocular Hypertension. 61
31824135 2019
12
Application of botulinum toxin in Horner's muscle for the treatment of dry eye. 61
30001848 2018
13
In Vivo Confocal Microscopy Analysis of the Corneal Layers in Adenoviral Epidemic Keratoconjunctivitis 61
30605932 2018
14
Adjunctive role of self-retained cryopreserved amniotic membrane in treating immune-related dry eye disease. 61
29101724 2018
15
Punctate epithelial keratoconjunctivitis: A microsporidial infestation. 61
30127158 2018
16
Significant correlation between meibomian gland dysfunction and keratitis in young patients with Demodex brevis infestation. 61
29055903 2018
17
Epidemic Keratoconjunctivitis: (Superficial Punctate Keratitis, Keratitis Subepithelialis, Keratitis Maculosa, Keratitis Nummularis) With a Review of the Literature and a Report of 125 Cases. 61
29793576 2018
18
On-eye breakage and recovery of mini-scleral contact lens without compromise for the ocular surface. 61
29248315 2018
19
Evaluation of a multifunctional femtosecond laser for the creation of laser in situ keratomileusis flaps. 61
29703284 2018
20
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin. 61
29494606 2018
21
Real-life results of switching from preserved to preservative-free artificial tears containing hyaluronate in patients with dry eye disease. 61
30197497 2018
22
Ciliopathy: Sjögren-Larsson Syndrome. 61
30578509 2018
23
Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops. 61
29682341 2018
24
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. 61
29670328 2018
25
Treatment of adenoviral keratoconjunctivitis with a combination of povidone-iodine 1.0% and dexamethasone 0.1% drops: a clinical prospective controlled randomized study. 61
28342227 2017
26
One-year efficacy of adjunctive use of Ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy. 61
28711991 2017
27
Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors. 61
28440955 2017
28
Comparison of Safety and Efficacy of Botox and Neuronox in the Management of Benign Essential Blepharospasm: A Split-face Study. 61
29022290 2017
29
[Role of Köllner-Hughes tarsoconjunctival flap in the reconstruction of large eyelid defects]. 61
28478019 2017
30
Graves' Ophthalmopathy in a Paediatric Population. 61
28329893 2017
31
Outcome of the Modified Hughes Procedure for Eyelid Sebaceous Carcinoma. 61
30080002 2017
32
Autologous Platelet-Rich Plasma Eye Drops for the Treatment of Post-LASIK Chronic Ocular Surface Syndrome. 61
29379652 2017
33
Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area. 61
28300740 2017
34
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 61
26895272 2016
35
Prospective Observational Post-marketing Study of Tafluprost 0.0015%/Timolol 0.5% Combination Ophthalmic Solution for Glaucoma and Ocular Hypertension: Short-Term Efficacy and Safety. 61
27492380 2016
36
Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors. 61
27296769 2016
37
Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp. 61
27124778 2016
38
Effect of Switching to Travoprost Preserved With SofZia in Glaucoma Patients With Chronic Superficial Punctate Keratitis While Receiving BAK-preserved Latanoprost. 61
25967526 2016
39
Improvement of Subjective Symptoms and Eye Complications When Changing From 2-Week Frequent Replacement to Daily Disposable Contact Lenses in a Subscriber Membership System. 61
25996420 2016
40
Blepharokeratoconjunctivitis in childhood: corneal involvement and visual outcome. 61
26634709 2016
41
[Safety of the automated microkeratome for Sub-Bowman's Keratomileusis on the flat cornea]. 61
26549141 2016
42
Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy. 61
27032098 2016
43
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis. 61
26771164 2016
44
The use of autologous serum for the treatment of ocular surface disease at a Swedish tertiary referral center. 61
27042143 2016
45
Evaluation of the Effect of Latanoprostene Bunod Ophthalmic Solution, 0.024% in Lowering Intraocular Pressure over 24 h in Healthy Japanese Subjects. 61
26563323 2015
46
Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. 61
26133248 2015
47
Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis. 61
24240881 2015
48
Bimatoprost 0.03% for the Treatment of Eyelash Hypotrichosis: A Pooled Safety Analysis of Six Randomized, Double-masked Clinical Trials. 61
26203317 2015
49
From benzalkonium chloride-preserved Latanoprost to Polyquad-preserved Travoprost: a 6-month study on ocular surface safety and tolerability. 61
25759110 2015
50
Safety and Efficacy of Bimatoprost for Eyelash Growth in Postchemotherapy Subjects. 61
26060513 2015

Variations for Punctate Epithelial Keratoconjunctivitis

Expression for Punctate Epithelial Keratoconjunctivitis

Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.

Pathways for Punctate Epithelial Keratoconjunctivitis

Pathways related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.5 IFNA2 EGF CNTF
2 10.7 NGF EGF CNTF

GO Terms for Punctate Epithelial Keratoconjunctivitis

Cellular components related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TAC1 PTGFR NGF MUC16 IFNA2 EGF
2 axon GO:0030424 9.26 TAC1 SRCIN1 NGF CNTF
3 extracellular space GO:0005615 9.17 TAC1 NGF MUC16 IFNA2 EGF CTSF

Biological processes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding GO:0043388 9.16 NGF EGF
2 positive regulation of phosphorylation GO:0042327 8.96 IFNA2 EGF
3 positive regulation of gene expression GO:0010628 8.92 PTGFR NGF EGF CNTF

Molecular functions related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 NGF EGF CNTF

Sources for Punctate Epithelial Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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