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MCID: PNC012
MIFTS: 32

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

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MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Punctate Keratitis 12 74
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratitis 12
Punctate Epithelial Keratitis 74

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12197
ICD9CM 36 370.21
SNOMED-CT 69 42513006
ICD10 34 H16.14
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Summaries for Punctate Epithelial Keratoconjunctivitis

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MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as punctate keratitis, is related to thygeson superficial punctate keratopathy and keratitis, hereditary. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Interferon gamma signaling and Dendritic Cells Developmental Lineage Pathway. The drugs Miconazole and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye.

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Related Diseases for Punctate Epithelial Keratoconjunctivitis

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Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 thygeson superficial punctate keratopathy 11.3
2 keratitis, hereditary 10.6
3 heart block, congenital 10.3 TNFRSF25 TRIM21
4 diffuse scleroderma 10.3 TNFRSF25 TRIM21
5 sclerosing keratitis 10.3 B2M SRCIN1
6 idiopathic inflammatory myopathy 10.3 HLA-DRB1 TRIM21
7 herpangina 10.3 IFNA2 TNFRSF25
8 senile ectropion 10.2 KANTR SRCIN1
9 al amyloidosis 10.2 B2M CST3
10 paraphimosis 10.2 KANTR SRCIN1
11 discoid lupus erythematosus 10.2 HLA-DRB1 IFNA2
12 keratoconjunctivitis 10.1
13 facial hemiatrophy 10.1 KANTR TRIM21
14 subclavian steal syndrome 10.1 CD1A KANTR
15 visual agnosia 10.1 KANTR PSEN2
16 anteroseptal myocardial infarction 10.1 HLA-DRB1 KANTR
17 adie pupil 10.1 KANTR TNFRSF25 TRIM21
18 superficial keratitis 10.0 DHH IFNA2 PRPF6 SRCIN1 TNFRSF25
19 corneal dystrophy, thiel-behnke type 10.0
20 diarrhea 5, with tufting enteropathy, congenital 10.0
21 dry eye syndrome 10.0
22 myopia 10.0
23 shipyard eye 10.0
24 corneal dystrophy 10.0
25 conjunctivitis 10.0
26 oculogyric crisis 10.0 B2M KANTR
27 functional colonic disease 9.9 B2M KANTR
28 acute retrobulbar neuritis 9.9 B2M TRIM21
29 intraocular retinoblastoma 9.6 KANTR MLX

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis
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Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

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Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

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Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Anti-Infective Agents Phase 4,Not Applicable
5 Ophthalmic Solutions Phase 4,Not Applicable
6 Pharmaceutical Solutions Phase 4,Not Applicable
7 Peripheral Nervous System Agents Phase 4
8 Anti-Inflammatory Agents Phase 4
9 HIV Protease Inhibitors Phase 4
10 Hormones Phase 4
11
protease inhibitors Phase 4
12 Autonomic Agents Phase 4
13 BB 1101 Phase 4
14 Immunosuppressive Agents Phase 4,Not Applicable
15 Antineoplastic Agents, Hormonal Phase 4
16 Hormone Antagonists Phase 4
17 Immunologic Factors Phase 4,Not Applicable
18 Antiemetics Phase 4
19 Cyclosporins Phase 4,Not Applicable
20 Antifungal Agents Phase 4,Not Applicable
21 Dermatologic Agents Phase 4,Not Applicable
22 Antirheumatic Agents Phase 4,Not Applicable
23 Gastrointestinal Agents Phase 4
24 Calcineurin Inhibitors Phase 4,Not Applicable
25 glucocorticoids Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27
Norgestimate Approved, Investigational Not Applicable 35189-28-7 6540478
28
Moxifloxacin Approved, Investigational Not Applicable 354812-41-2, 151096-09-2 152946
29
Polyestradiol phosphate Approved Not Applicable 28014-46-2
30
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
31
Ethinyl Estradiol Approved Not Applicable 57-63-6 5991
32
Gatifloxacin Approved, Investigational Not Applicable 112811-59-3 5379
33 Contraceptives, Oral, Combined Not Applicable
34 Estradiol 3-benzoate Not Applicable
35 Norgestimate, ethinyl estradiol drug combination Not Applicable
36 Topoisomerase Inhibitors Not Applicable
37 Estradiol 17 beta-cypionate Not Applicable
38 Mitomycins Not Applicable
39 Contraceptives, Oral Not Applicable
40 Contraceptive Agents Not Applicable
41 Anti-Bacterial Agents Not Applicable
42 Lubricant Eye Drops

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101 Unknown status NCT02656394 Phase 2 GL101;Placebo
3 Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca Completed NCT00349466 Phase 2 CF101;Placebo
4 Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision Unknown status NCT00892918 Not Applicable Moxifloxacin ophthalmic solution 0.5% ; Gatifloxacin ophthalmic solution 0.3%
5 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
6 DRy Eye Outcome and Prescription Study Recruiting NCT03652415

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

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Genetic Tests for Punctate Epithelial Keratoconjunctivitis

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Anatomical Context for Punctate Epithelial Keratoconjunctivitis

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MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

42
Eye
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Publications for Punctate Epithelial Keratoconjunctivitis

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Articles related to Punctate Epithelial Keratoconjunctivitis:

(show top 50) (show all 63)
# Title Authors Year
1
Punctate epithelial keratoconjunctivitis: A microsporidial infestation. ( 30127158 )
2018
2
Effect of Switching to Travoprost Preserved With SofZia in Glaucoma Patients With Chronic Superficial Punctate Keratitis While Receiving BAK-preserved Latanoprost. ( 25967526 )
2016
3
Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. ( 26133248 )
2015
4
Automated Grading System for Evaluation of Superficial Punctate Keratitis Associated With Dry Eye. ( 26066593 )
2015
5
Unilateral punctate keratitis secondary to Wallenberg Syndrome. ( 24882965 )
2014
6
Laser confocal microscopy findings of Thygeson superficial punctate keratitis. ( 24451976 )
2014
7
In vivo laser confocal microscopy findings of Thygeson superficial punctate keratitis. ( 21562457 )
2011
8
The role of benzalkonium chloride in the occurrence of punctate keratitis: a meta-analysis of randomized, controlled clinical trials. ( 21119099 )
2010
9
In vivo observation of Langerhans cells by laser confocal microscopy in Thygeson's superficial punctate keratitis. ( 19649162 )
2009
10
Long-term topical cyclosporin A therapy in Thygeson's superficial punctate keratitis: a case report. ( 19105827 )
2008
11
The role of common viral ocular pathogens in Thygeson's superficial punctate keratitis. ( 17389746 )
2007
12
Diffuse punctate keratitis in a patient treated with cetuximab as monotherapy. ( 17442661 )
2007
13
Diagnosis and management of Thygeson's superficial punctate keratitis. ( 17601570 )
2007
14
Thygeson's superficial punctate keratitis: ten years' experience. ( 14711711 )
2004
15
PCR for varicella zoster virus genome negative in corneal epithelial cells of patients with Thygeson's superficial punctate keratitis. ( 15004582 )
2004
16
Corneal surface changes in Thygeson's superficial punctate keratitis: a clinical and non-contact photomicrographic in vivo study in the human cornea. ( 15134103 )
2004
17
In vivo confocal microscopy of Thygeson's superficial punctate keratitis. ( 15180847 )
2004
18
Thygeson's superficial punctate keratitis recurrence after laser in situ keratomileusis. ( 15364251 )
2004
19
Dry eyes and superficial punctate keratitis: a complication of treatment of glabelar dynamic rhytides with botulinum exotoxin A. ( 15606828 )
2004
20
Recurrence of Thygeson's superficial punctate keratitis after photorefractive keratectomy. ( 12352102 )
2002
21
Photorefractive keratectomy for myopia in the setting of Thygeson's superficial punctate keratitis. ( 11333334 )
2001
22
Topical cyclosporin A in Thygeson's superficial punctate keratitis. ( 9987626 )
1999
23
Superficial punctate keratitis of thygeson: the longest course on record? ( 10571306 )
1999
24
Effect of topical cyclosporin A on Thygeson's superficial punctate keratitis. ( 9550347 )
1996
25
A classical case of Thygeson's superficial punctate keratitis. ( 7619463 )
1995
26
Handling punctate keratitis resulting from systemic cytarabine. ( 8239322 )
1993
27
Superficial punctate keratitis and corneal abrasion due to amantadine hydrochloride. ( 8336180 )
1993
28
Persistent superficial punctate keratitis after resolution of chlamydial follicular conjunctivitis. ( 1424659 )
1992
29
Effect of diethylcarbamazine citrate and anti-inflammatory drugs on experimental onchocercal punctate keratitis. ( 2443887 )
1987
30
Punctate keratitis induced by subconjunctivally injected microfilariae of Onchocerca lienalis. ( 3718315 )
1986
31
Thygeson's superficial punctate keratitis. ( 3994215 )
1985
32
Effect of topical trifluridine on Thygeson's superficial punctate keratitis. ( 6440070 )
1984
33
The differential diagnosis of superficial punctate keratitis. ( 6724823 )
1984
34
Superficial punctate keratitis of Thygeson. ( 7153449 )
1982
35
Thygeson's superficial punctate keratitis. ( 6264365 )
1981
36
HLA DR3 in Thygeson's superficial punctate keratitis. ( 6950542 )
1981
37
Thygeson's superficial punctate keratitis: natural history and association with HLA DR3. ( 7043867 )
1981
38
Management of Thygeson's superficial punctate keratitis. ( 6892542 )
1980
39
Superficial punctate keratitis of Thygeson associated with scarring and Salzmann's nodular degeneration. ( 434089 )
1979
40
Viral isolate in superficial punctate keratitis. ( 4357790 )
1974
41
Morphology of experimental vaccinial superficial punctate keratitis--a scanning and transmission electron microscopic study. ( 5104475 )
1971
42
Superficial punctate keratitis. ( 5164927 )
1971
43
Clinical and laboratory observations on superficial punctate keratitis. ( 5938018 )
1966
44
THYGESON'S SUPERFICIAL PUNCTATE KERATITIS. ( 14123149 )
1963
45
Differential diagnosis of punctate keratitis. ( 13964692 )
1962
46
Epithelial punctate keratitis after topical prednisolone. ( 14423046 )
1960
47
Superficial punctate keratitis; in association with oculomotor and trochlear nerve palsy. ( 13670251 )
1959
48
Superficial punctate keratitis; isolation of a virus. ( 13064890 )
1953
49
Superficial punctate keratitis; the isolation of a virus. ( 14922444 )
1951
50
Superficial Punctate Keratitis: The Isolation of a Virus. ( 16693542 )
1951
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Variations for Punctate Epithelial Keratoconjunctivitis

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Expression for Punctate Epithelial Keratoconjunctivitis

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Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.
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Pathways for Punctate Epithelial Keratoconjunctivitis

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Pathways related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Interferon gamma signaling 67
Show member pathways
 11.75 B2M HLA-DRB1 IFNA2 TRIM21
2
Dendritic Cells Developmental Lineage Pathway 66
10.67 CD1A EPCAM IFNA2
3
A-beta Pathways: Plaque Formation and APP Metabolism 66
10.52 CST3 PSEN2
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GO Terms for Punctate Epithelial Keratoconjunctivitis

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Cellular components related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 B2M CD1A EPCAM HLA-DRB1 SLC6A1

Biological processes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell mediated cytotoxicity GO:0001916 8.96 B2M CD1A
2 interferon-gamma-mediated signaling pathway GO:0060333 8.8 B2M HLA-DRB1 TRIM21
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Sources for Punctate Epithelial Keratoconjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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