MCID: PNC012
MIFTS: 23

Punctate Epithelial Keratoconjunctivitis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Punctate Epithelial Keratoconjunctivitis

MalaCards integrated aliases for Punctate Epithelial Keratoconjunctivitis:

Name: Punctate Epithelial Keratoconjunctivitis 12 15
Thygeson Superficial Punctate Keratitis 12 58
Punctate Keratitis 12 71
Thygeson's Superficial Punctate Keratitis 12
Thygeson Superficial Punctate Keratopathy 58
Punctate Epithelial Keratitis 71

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12197
ICD9CM 34 370.21
SNOMED-CT 67 42513006
ICD10 32 H16.14
Orphanet 58 ORPHA519406
UMLS 71 C0259799 C1562761

Summaries for Punctate Epithelial Keratoconjunctivitis

MalaCards based summary : Punctate Epithelial Keratoconjunctivitis, also known as thygeson superficial punctate keratitis, is related to keratopathy and corneal ulcer. An important gene associated with Punctate Epithelial Keratoconjunctivitis is SRCIN1 (SRC Kinase Signaling Inhibitor 1). The drugs Hyaluronic acid and Viscosupplements have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Punctate Epithelial Keratoconjunctivitis

Diseases related to Punctate Epithelial Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 keratopathy 29.9 TAC1 OGFR LACRT
2 corneal ulcer 29.9 NGF LACRT KRT3
3 dry eye syndrome 29.4 P2RY2 NGF LACRT
4 keratitis, hereditary 11.0
5 ocular hyperemia 10.3 PTGFR EVC2
6 superficial keratitis 10.3
7 conjunctivitis 10.3
8 chickenpox 10.3
9 senile ectropion 10.3 SRCIN1 MUC16
10 deep keratitis 10.2 SRCIN1 KRT3
11 prurigo nodularis 10.2 TAC1 NGF
12 detrusor sphincter dyssynergia 10.2 TAC1 NGF
13 cough variant asthma 10.2 TAC1 NGF
14 algoneurodystrophy 10.2 TAC1 NGF
15 ocular hypertension 10.2
16 chronic cystitis 10.2 TAC1 NGF
17 recurrent corneal erosion 10.2 TENT5D KRT3
18 trigeminal nerve disease 10.2 TAC1 NGF
19 corneal degeneration 10.2 TENT5D KRT3
20 keratoconjunctivitis 10.1
21 mononeuropathy 10.1 TAC1 NGF
22 nerve compression syndrome 10.1 TAC1 NGF
23 corneal ectasia 10.1 SBK1 KRT3
24 polyradiculopathy 10.1 TAC1 NGF
25 trigeminal neuralgia 10.1 TAC1 NGF
26 burning mouth syndrome 10.1 TAC1 NGF
27 serotonin syndrome 10.1 TAC1 IFNA2
28 eyelid disease 10.1 SRCIN1 MUC16 LACRT
29 blepharitis 10.0 MUC16 LACRT
30 keratoconjunctivitis sicca 10.0 NGF LACRT
31 corneal dystrophy, band-shaped 10.0
32 corneal dystrophy, thiel-behnke type 10.0
33 diarrhea 5, with tufting enteropathy, congenital 10.0
34 joint laxity, short stature, and myopia 10.0
35 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
36 open-angle glaucoma 10.0
37 chlamydia 10.0
38 corneal neovascularization 10.0
39 onchocerciasis 10.0
40 myopia 10.0
41 paralytic lagophthalmos 10.0
42 lagophthalmos 10.0
43 shipyard eye 10.0
44 diarrhea 10.0
45 inclusion conjunctivitis 10.0
46 corneal dystrophy 10.0
47 herpes zoster 10.0
48 herpes simplex 10.0
49 steroid-induced glaucoma 10.0
50 herpes zoster ophthalmicus 10.0

Graphical network of the top 20 diseases related to Punctate Epithelial Keratoconjunctivitis:



Diseases related to Punctate Epithelial Keratoconjunctivitis

Symptoms & Phenotypes for Punctate Epithelial Keratoconjunctivitis

GenomeRNAi Phenotypes related to Punctate Epithelial Keratoconjunctivitis according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.58 OGFR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.58 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.58 OGFR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.58 IFNA2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.58 NGF
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.58 NGF
7 Increased shRNA abundance (Z-score > 2) GR00366-A-167 9.58 IFNA2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.58 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.58 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.58 OGFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 NGF
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.58 IFNA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 IFNA2 NGF OGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.58 NGF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.58 IFNA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 OGFR

Drugs & Therapeutics for Punctate Epithelial Keratoconjunctivitis

Drugs for Punctate Epithelial Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
2 Viscosupplements Phase 3
3 Adjuvants, Immunologic Phase 3
4 Protective Agents Phase 3
5 Ophthalmic Solutions Phase 3
6 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Multicenter, Randomized, Double-Masked Study of Safety and Efficacy of Vismed® in Dry Eye Syndrome Completed NCT00599716 Phase 3 sodium hyaluronate;vehicle

Search NIH Clinical Center for Punctate Epithelial Keratoconjunctivitis

Genetic Tests for Punctate Epithelial Keratoconjunctivitis

Anatomical Context for Punctate Epithelial Keratoconjunctivitis

MalaCards organs/tissues related to Punctate Epithelial Keratoconjunctivitis:

40
Eye

Publications for Punctate Epithelial Keratoconjunctivitis

Articles related to Punctate Epithelial Keratoconjunctivitis:

# Title Authors PMID Year
1
Clinical Profile of Bilateral Microsporidial Keratoconjunctivitis in Healthy Individuals-A Case Series With Long-term Follow-up. 61
32141940 2020
2
Topical Tacrolimus in Thygeson Superficial Punctate Keratitis. 61
31842035 2020
3
Multifocal Vortex Keratopathy. 61
32073455 2020
4
Punctate epithelial keratoconjunctivitis: A microsporidial infestation. 61
30127158 2018
5
Laser confocal microscopy findings of Thygeson superficial punctate keratitis. 61
24451976 2014
6
Thygeson superficial punctate keratitis and scarring. 61
22495026 2012
7
In vivo laser confocal microscopy findings of Thygeson superficial punctate keratitis. 61
21562457 2011
8
Disappearance of honeycomb opacity of Thiel-Behnke corneal dystrophy after Thygeson superficial punctate keratitis. 61
16227859 2005
9
[Local cyclosporin A therapy in Thygeson superficial punctate keratitis--a pilot study]. 61
9044962 1996

Variations for Punctate Epithelial Keratoconjunctivitis

Expression for Punctate Epithelial Keratoconjunctivitis

Search GEO for disease gene expression data for Punctate Epithelial Keratoconjunctivitis.

Pathways for Punctate Epithelial Keratoconjunctivitis

GO Terms for Punctate Epithelial Keratoconjunctivitis

Sources for Punctate Epithelial Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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