PIC
MCID: PNC059
MIFTS: 33

Punctate Inner Choroidopathy (PIC)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

MalaCards integrated aliases for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 53 73
Multifocal Inner Choroiditis 53
Punctate Inner Choroiditis 53
Pic 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 73 C0730321

Summaries for Punctate Inner Choroidopathy

NIH Rare Diseases : 53 Punctate inner choroidopathy (PIC) is an inflammatory disorder that primarily affects the choroid (vascular layer) of the eye. It most commonly occurs in young, near-sighted (myopic) women. The symptoms and severity may vary from person to person. Symptoms may include a blind spot (scotomata), blurred vision, photopsia (perceived flashes of light), floaters, light sensitivity (photophobia), distorted vision, and/or loss of peripheral vision. The majority of cases are self-limited (resolving on their own) with good visual prognosis, but permanent, severe visual loss can occur as a result of inflammation and complications such as growth of additional blood vessels (neovascularization) and scarring. The exact cause of PIC is not known, but it is thought to involve both genetic predisposition and environmental factors. It is proposed to be an autoimmune disease in which multiple genes interact with each other and an environmental "trigger" (such as an infection or stress) to cause a person to develop PIC. Treatment is challenging and depends on the course of the disease and whether complications arise. The majority of people with PIC who do not have neovascularization do not require treatment. For those who develop complications or have a more severe disease course, treatment may involve local or systemic corticosteroids, other immunosuppressive therapies, intravitreal anti-VEGF therapy, laser photocoagulation, photodynamic therapy, and/or surgery.

MalaCards based summary : Punctate Inner Choroidopathy, also known as multifocal inner choroiditis, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways/superpathways are Th17 cell differentiation and Immune response IL-23 signaling pathway. Affiliated tissues include eye, lung and skin.

Related Diseases for Punctate Inner Choroidopathy

Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 choroiditis 31.2 IL10 TNF
2 multifocal choroiditis 31.1 IL10 TNF
3 panuveitis 30.8 IL10 TNF
4 acute zonal occult outer retinopathy 10.4
5 neuroretinitis 10.2
6 histoplasmosis 10.2
7 optic nerve disease 10.2
8 neuropathy 10.2
9 central serous chorioretinopathy 10.2
10 tropical endomyocardial fibrosis 10.0 IL10 TNF
11 endomyocardial fibrosis 10.0 IL10 TNF
12 microscopic polyangiitis 10.0 IL10 TNF
13 tungiasis 10.0 IL10 TNF
14 transient hypogammaglobulinemia 10.0 IL10 TNF
15 cow milk allergy 10.0 IL10 TNF
16 trichuriasis 10.0 IL10 TNF
17 idiopathic achalasia 10.0 IL10 TNF
18 mucocutaneous leishmaniasis 10.0 IL10 TNF
19 cutaneous leishmaniasis 10.0 IL10 TNF
20 leishmaniasis 10.0 IL10 TNF
21 chronic graft versus host disease 10.0 IL10 TNF
22 clonorchiasis 10.0 IL10 TNF
23 trachoma 10.0 IL10 TNF
24 autoimmune gastritis 10.0 IL10 TNF
25 autoimmune disease 10.0 IL10 TNF
26 autoimmune disease of eyes, ear, nose and throat 10.0 IL10 TNF
27 intermediate uveitis 10.0 IL10 TNF
28 uveitis 10.0 IL10 TNF
29 orofacial granulomatosis 10.0 IL10 TNF
30 transverse myelitis 10.0 IL10 TNF
31 post-transplant lymphoproliferative disease 10.0 IL10 TNF
32 primary systemic mycosis 10.0 IL10 TNF
33 mycoplasma pneumoniae pneumonia 10.0 IL10 TNF
34 pneumonia 10.0 IL10 TNF
35 multidrug-resistant tuberculosis 10.0 IL10 TNF
36 poliomyelitis 10.0 IL10 TNF
37 eales disease 10.0 IL10 TNF
38 hemorrhagic fever 10.0 IL10 TNF
39 spotted fever 10.0 IL10 TNF
40 coccidiosis 10.0 IL10 TNF
41 hematopoietic stem cell transplantation 10.0 IL10 TNF
42 aseptic meningitis 10.0 IL10 TNF
43 meningitis 10.0 IL10 TNF
44 scrub typhus 10.0 IL10 TNF
45 plasmodium vivax malaria 10.0 IL10 TNF
46 bacterial sepsis 10.0 IL10 TNF
47 lacrimal apparatus disease 10.0 IL10 TNF
48 commensal bacterial infectious disease 10.0 IL10 TNF
49 bacterial infectious disease 10.0 IL10 TNF
50 churg-strauss syndrome 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to Punctate Inner Choroidopathy

Symptoms & Phenotypes for Punctate Inner Choroidopathy

Drugs & Therapeutics for Punctate Inner Choroidopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03793400 Bevacizumab Injection
2 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

Anatomical Context for Punctate Inner Choroidopathy

MalaCards organs/tissues related to Punctate Inner Choroidopathy:

41
Eye, Lung, Skin, Bone, Heart, Lymph Node, Prostate

Publications for Punctate Inner Choroidopathy

Articles related to Punctate Inner Choroidopathy:

(show top 50) (show all 86)
# Title Authors Year
1
Optical coherence tomography angiography in comparison with other multimodal imaging techniques in punctate inner choroidopathy. ( 29581353 )
2018
2
Long-term results of intravitreal bevacizumab and dexamethasone for the treatment of punctate inner choroidopathy associated with choroidal neovascularization: A case series. ( 29760922 )
2018
3
Risk Factors for Developing Choroidal Neovascular Membrane and Visual Loss in Punctate Inner Choroidopathy. ( 28993011 )
2018
4
Treatment of Punctate Inner Choroidopathy with Choroidal Neovascularization Using Corticosteroid and Intravitreal Ranibizumab. ( 30302336 )
2018
5
Immunosuppressants and/or antivascular endothelial growth factor inhibitors in punctate inner choroidopathy? Follow-up results with optical coherence tomography angiography. ( 30337330 )
2018
6
Development of Secondary Choroidal Neovascularization in Focal Choroidal Excavation of Punctate Inner Choroidopathy. ( 30422049 )
2018
7
Punctate Inner Choroidopathy and Choroidal Neovascularization in Korean Patients. ( 30547702 )
2018
8
Optical Coherence Tomography Angiography Findings in Punctate Inner Choroidopathy. ( 29020421 )
2017
9
Optical Coherence Tomography Angiography of Punctate Inner Choroidopathy. ( 29230338 )
2017
10
Intravitreal anti-VEGF treatment for choroidal neovascularization secondary to punctate inner choroidopathy. ( 28424992 )
2017
11
Efficacy and safety of conbercept as a primary treatment for choroidal neovascularization secondary to punctate inner choroidopathy. ( 28606070 )
2017
12
How to Differentiate Myopic Choroidal Neovascularization, Idiopathic Multifocal Choroiditis, and Punctate Inner Choroidopathy Using Clinical and Multimodal Imaging Findings. ( 28297030 )
2017
13
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. ( 27555066 )
2016
14
Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. ( 26965893 )
2016
15
Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy. ( 27977842 )
2016
16
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. ( 27539089 )
2016
17
Combined treatment in punctate inner choroidopathy. ( 27729795 )
2016
18
Punctate inner choroidopathy: A review. ( 27751823 )
2016
19
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. ( 26421890 )
2015
20
Punctate inner choroidopathy in systemic lupus. ( 25648066 )
2015
21
Punctate Inner Choroidopathy. ( 26060591 )
2015
22
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. ( 25631844 )
2015
23
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. ( 26955337 )
2015
24
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. ( 25687028 )
2015
25
The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy. ( 26266044 )
2015
26
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy. ( 24885365 )
2014
27
Clinical features and incidence rate of ocular complications in punctate inner choroidopathy. ( 24743642 )
2014
28
Punctate inner choroidopathy: a systematic review. ( 25741523 )
2014
29
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. ( 25046400 )
2014
30
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. ( 24856311 )
2014
31
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. ( 25322466 )
2014
32
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. ( 25370399 )
2014
33
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. ( 23805787 )
2013
34
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. ( 23584703 )
2013
35
Punctate inner choroidopathy: a clinical case report. ( 24163685 )
2013
36
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. ( 23769333 )
2013
37
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. ( 23163572 )
2012
38
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. ( 22954947 )
2012
39
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. ( 22352824 )
2012
40
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. ( 22481479 )
2012
41
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. ( 25390960 )
2012
42
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. ( 22210152 )
2012
43
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. ( 24269388 )
2012
44
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. ( 22824619 )
2012
45
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. ( 25389949 )
2012
46
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. ( 22120962 )
2012
47
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. ( 21772986 )
2011
48
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. ( 21188681 )
2011
49
Punctate inner choroidopathy. ( 21056447 )
2011
50
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. ( 21275596 )
2011

Variations for Punctate Inner Choroidopathy

Expression for Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for Punctate Inner Choroidopathy

Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.15 IL10 TNF
2
Show member pathways
12.13 IL10 TNF
3 12.11 IL10 TNF
4
Show member pathways
11.99 IL10 TNF
5
Show member pathways
11.85 IL10 TNF
6
Show member pathways
11.81 IL10 TNF
7 11.81 IL10 TNF
8
Show member pathways
11.79 IL10 TNF
9 11.75 IL10 TNF
10
Show member pathways
11.64 IL10 TNF
11 11.57 IL10 TNF
12 11.55 IL10 TNF
13 11.46 IL10 TNF
14 11.36 IL10 TNF
15 11.31 IL10 TNF
16 11.27 IL10 TNF
17 11.22 IL10 TNF
18 11.01 IL10 TNF
19 10.95 IL10 TNF
20 10.8 IL10 TNF
21 10.7 IL10 TNF
22 10.5 IL10 TNF
23 10.09 IL10 TNF

GO Terms for Punctate Inner Choroidopathy

Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 IL10 TNF
2 defense response to bacterium GO:0042742 9.55 IL10 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.54 IL10 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.52 IL10 TNF
5 response to organic substance GO:0010033 9.51 IL10 TNF
6 response to glucocorticoid GO:0051384 9.49 IL10 TNF
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.48 IL10 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.46 IL10 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.43 IL10 TNF
10 positive regulation of cytokine secretion GO:0050715 9.4 IL10 TNF
11 regulation of synapse organization GO:0050807 9.37 IL10 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.32 IL10 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 IL10 TNF
14 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
16 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 IL10 TNF

Sources for Punctate Inner Choroidopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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