MCID: PNC059
MIFTS: 30

Punctate Inner Choroidopathy

Categories: Rare diseases

Aliases & Classifications for Punctate Inner Choroidopathy

MalaCards integrated aliases for Punctate Inner Choroidopathy:

Name: Punctate Inner Choroidopathy 53 73
Pic 53

Classifications:



External Ids:

UMLS 73 C0730321

Summaries for Punctate Inner Choroidopathy

NIH Rare Diseases : 53 Punctate inner choroidopathy (PIC) is an inflammatory disorder that primarily affects the choroid of the eye and occurs predominantly in young, nearsighted (myopic) women. Signs and symptoms may include scotomata, blurred vision, photopsias, floaters, photophobia, distorted vision (metamorphopsia), and/or loss of peripheral vision. The majority of cases are self-limited with good visual prognosis, but permanent and severe visual loss can occur as a result of the development of choroidal neovascular membranes (CNV). The cause of PIC is not known, but it is thought to involve both genetic predisposition and environmental factors. The majority of affected individuals who do not have CNV do not require treatment; for others, treatment may include medication, laser photocoagulation, photodynamic therapy (treatment with drugs that become active when exposed to light) and/or surgery.

MalaCards based summary : Punctate Inner Choroidopathy, also known as pic, is related to choroiditis and multifocal choroiditis. An important gene associated with Punctate Inner Choroidopathy is IL10 (Interleukin 10), and among its related pathways/superpathways are Regulation of IFNA signaling and Immune response IL-23 signaling pathway. Affiliated tissues include eye.

Related Diseases for Punctate Inner Choroidopathy

Diseases related to Punctate Inner Choroidopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 choroiditis 31.4 IL10 TNF
2 multifocal choroiditis 31.0 IL10 TNF
3 panuveitis 30.6 IL10 TNF
4 acute zonal occult outer retinopathy 10.2
5 retinitis 10.2
6 central serous chorioretinopathy 10.1
7 aging 10.1
8 neuroretinitis 10.1
9 histoplasmosis 10.1
10 optic nerve disease 10.1
11 neuropathy 10.1
12 tropical endomyocardial fibrosis 10.0 IL10 TNF
13 microscopic polyangiitis 10.0 IL10 TNF
14 tungiasis 10.0 IL10 TNF
15 endomyocardial fibrosis 10.0 IL10 TNF
16 transient hypogammaglobulinemia 10.0 IL10 TNF
17 idiopathic achalasia 10.0 IL10 TNF
18 trichuriasis 10.0 IL10 TNF
19 mucocutaneous leishmaniasis 10.0 IL10 TNF
20 clonorchiasis 10.0 IL10 TNF
21 trachoma 10.0 IL10 TNF
22 listeriosis 10.0 IL10 TNF
23 transverse myelitis 10.0 IL10 TNF
24 primary systemic mycosis 10.0 IL10 TNF
25 poliomyelitis 10.0 IL10 TNF
26 intermediate uveitis 10.0 IL10 TNF
27 multidrug-resistant tuberculosis 10.0 IL10 TNF
28 orofacial granulomatosis 10.0 IL10 TNF
29 post-transplant lymphoproliferative disease 10.0 IL10 TNF
30 coccidiosis 10.0 IL10 TNF
31 eales disease 10.0 IL10 TNF
32 hemorrhagic fever 10.0 IL10 TNF
33 spotted fever 10.0 IL10 TNF
34 hematopoietic stem cell transplantation 10.0 IL10 TNF
35 aseptic meningitis 10.0 IL10 TNF
36 scrub typhus 10.0 IL10 TNF
37 cytomegalovirus infection 10.0 IL10 TNF
38 plasmodium vivax malaria 10.0 IL10 TNF
39 q fever 10.0 IL10 TNF
40 lacrimal apparatus disease 10.0 IL10 TNF
41 aphthous stomatitis 10.0 IL10 TNF
42 churg-strauss syndrome 10.0 IL10 TNF
43 severe hemophilia a 10.0 IL10 TNF
44 epstein-barr virus-associated gastric carcinoma 10.0 IL10 TNF
45 lepromatous leprosy 10.0 IL10 TNF
46 hemorrhagic fever with renal syndrome 10.0 IL10 TNF
47 extrinsic cardiomyopathy 10.0 IL10 TNF
48 viral encephalitis 10.0 IL10 TNF
49 acute graft versus host disease 10.0 IL10 TNF
50 complex regional pain syndrome 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Punctate Inner Choroidopathy:



Diseases related to Punctate Inner Choroidopathy

Symptoms & Phenotypes for Punctate Inner Choroidopathy

Drugs & Therapeutics for Punctate Inner Choroidopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Punctate Inner Choroidopathy

Genetic Tests for Punctate Inner Choroidopathy

Anatomical Context for Punctate Inner Choroidopathy

MalaCards organs/tissues related to Punctate Inner Choroidopathy:

41
Eye

Publications for Punctate Inner Choroidopathy

Articles related to Punctate Inner Choroidopathy:

(show top 50) (show all 82)
# Title Authors Year
1
Optical coherence tomography angiography in comparison with other multimodal imaging techniques in punctate inner choroidopathy. ( 29581353 )
2018
2
Long-term results of intravitreal bevacizumab and dexamethasone for the treatment of punctate inner choroidopathy associated with choroidal neovascularization: A case series. ( 29760922 )
2018
3
Risk Factors for Developing Choroidal Neovascular Membrane and Visual Loss in Punctate Inner Choroidopathy. ( 28993011 )
2018
4
Optical Coherence Tomography Angiography Findings in Punctate Inner Choroidopathy. ( 29020421 )
2017
5
Optical Coherence Tomography Angiography of Punctate Inner Choroidopathy. ( 29230338 )
2017
6
Intravitreal anti-VEGF treatment for choroidal neovascularization secondary to punctate inner choroidopathy. ( 28424992 )
2017
7
Efficacy and safety of conbercept as a primary treatment for choroidal neovascularization secondary to punctate inner choroidopathy. ( 28606070 )
2017
8
How to Differentiate Myopic Choroidal Neovascularization, Idiopathic Multifocal Choroiditis, and Punctate Inner Choroidopathy Using Clinical and Multimodal Imaging Findings. ( 28297030 )
2017
9
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. ( 27555066 )
2016
10
Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. ( 26965893 )
2016
11
Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy. ( 27977842 )
2016
12
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. ( 27539089 )
2016
13
Combined treatment in punctate inner choroidopathy. ( 27729795 )
2016
14
Punctate inner choroidopathy: A review. ( 27751823 )
2016
15
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND WIDEFIELD FUNDUS AUTOFLUORESCENCE IN PUNCTATE INNER CHOROIDOPATHY. ( 26421890 )
2015
16
Punctate inner choroidopathy in systemic lupus. ( 25648066 )
2015
17
Punctate Inner Choroidopathy. ( 26060591 )
2015
18
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. ( 25631844 )
2015
19
Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy. ( 26955337 )
2015
20
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. ( 25687028 )
2015
21
The Fundus Autofluorescence Spectrum of Punctate Inner Choroidopathy. ( 26266044 )
2015
22
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy. ( 24885365 )
2014
23
Clinical features and incidence rate of ocular complications in punctate inner choroidopathy. ( 24743642 )
2014
24
Punctate inner choroidopathy: a systematic review. ( 25741523 )
2014
25
Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. ( 25046400 )
2014
26
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. ( 24856311 )
2014
27
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. ( 25322466 )
2014
28
Unilateral Punctate inner choroidopathy with choroidal neovascular membrane in a young male. ( 25370399 )
2014
29
Punctate inner choroidopathy and optic neuropathy: simultaneous presentation in a patient - a case report. ( 23805787 )
2013
30
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. ( 23584703 )
2013
31
Punctate inner choroidopathy: a clinical case report. ( 24163685 )
2013
32
Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. ( 23769333 )
2013
33
Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. ( 23163572 )
2012
34
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. ( 22954947 )
2012
35
Management of inflammatory choroidal neovascularization (CNV) secondary to punctate inner choroidopathy in a young female of childbearing age with intra-vitreal ranibizumab and half-fluence photodynamic therapy (PDT) - a holistic approach. ( 22352824 )
2012
36
Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. ( 22481479 )
2012
37
Spectral-domain optical coherence tomographic findings in punctate inner choroidopathy. ( 25390960 )
2012
38
Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. ( 22210152 )
2012
39
Intravitreal ranibizumab in the treatment of subretinal neovascularization in a case of punctate inner choroidopathy. ( 24269388 )
2012
40
Flare up of choroiditis and choroidal neovasculazation associated with punctate inner choroidopathy during early pregnancy. ( 22824619 )
2012
41
Migrating behavior of presumed Toxocara presenting as punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. ( 25389949 )
2012
42
Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. ( 22120962 )
2012
43
Using spectral-domain optical coherence tomography to follow outer retinal structure changes in a patient with recurrent punctate inner choroidopathy. ( 21772986 )
2011
44
Visual and optical coherence tomography outcomes of intravitreal bevacizumab and ranibizumab in inflammatory choroidal neovascularization secondary to punctate inner choroidopathy. ( 21188681 )
2011
45
Punctate inner choroidopathy. ( 21056447 )
2011
46
Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. ( 21275596 )
2011
47
Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. ( 21770809 )
2011
48
Clinical features of punctate inner choroidopathy in Chinese patients. ( 21499193 )
2011
49
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. ( 21357402 )
2011
50
Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. ( 21478811 )
2011

Variations for Punctate Inner Choroidopathy

Expression for Punctate Inner Choroidopathy

Search GEO for disease gene expression data for Punctate Inner Choroidopathy.

Pathways for Punctate Inner Choroidopathy

Pathways related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 IL10 TNF
2
Show member pathways
12.13 IL10 TNF
3 12.11 IL10 TNF
4
Show member pathways
12 IL10 TNF
5
Show member pathways
11.98 IL10 TNF
6
Show member pathways
11.83 IL10 TNF
7
Show member pathways
11.82 IL10 TNF
8 11.79 IL10 TNF
9
Show member pathways
11.76 IL10 TNF
10 11.72 IL10 TNF
11 11.56 IL10 TNF
12 11.53 IL10 TNF
13 11.44 IL10 TNF
14 11.34 IL10 TNF
15 11.28 IL10 TNF
16 11.24 IL10 TNF
17 11.01 IL10 TNF
18 10.95 IL10 TNF
19 10.7 IL10 TNF
20 10.5 IL10 TNF
21 10.1 IL10 TNF

GO Terms for Punctate Inner Choroidopathy

Biological processes related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.55 IL10 TNF
2 defense response to bacterium GO:0042742 9.54 IL10 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.52 IL10 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.51 IL10 TNF
5 response to organic substance GO:0010033 9.49 IL10 TNF
6 response to glucocorticoid GO:0051384 9.48 IL10 TNF
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 IL10 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.43 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.4 IL10 TNF
10 negative regulation of interleukin-6 production GO:0032715 9.37 IL10 TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.32 IL10 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 IL10 TNF
13 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
14 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
15 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Punctate Inner Choroidopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 IL10 TNF

Sources for Punctate Inner Choroidopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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