PPPP
MCID: PNC060
MIFTS: 28

Punctate Porokeratosis (PPPP)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Punctate Porokeratosis

MalaCards integrated aliases for Punctate Porokeratosis:

Name: Punctate Porokeratosis 20
Porokeratosis Punctata Palmaris Et Plantaris 20
Keratoderma, Palmoplantar, Punctate Type Ii 70
Porokeratosis, Punctate 70
Pppp 20

Classifications:



External Ids:

UMLS 70 C0949505 C1867982

Summaries for Punctate Porokeratosis

GARD : 20 Punctate porokeratosis is a skin condition that appears in adulthood as many, tiny, ridgelike bumps on the palms of the hands and soles of the feet. These bumps may slowly spread over the skin and usually do not cause symptoms, though they sometimes cause itching or discomfort while walking. Individuals with this condition often develop other types of porokeratosis as well. The cause of punctate porokeratosis is unknown, though genetic factors, a weakened immune system ( immunodeficiency ), or previous injury to the skin (for example, a burn) have been suggested as possible risk factors. Treatment depends on the size, location, and aggressiveness of porokeratosis in each affected individual; it may include observation only, medication, or surgery.

MalaCards based summary : Punctate Porokeratosis, also known as porokeratosis punctata palmaris et plantaris, is related to porokeratosis 1, multiple types and porokeratosis. An important gene associated with Punctate Porokeratosis is FDPS (Farnesyl Diphosphate Synthase), and among its related pathways/superpathways are Terpenoid backbone biosynthesis and Peroxisome. The drugs Ustekinumab and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, colon and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Punctate Porokeratosis

Graphical network of the top 20 diseases related to Punctate Porokeratosis:



Diseases related to Punctate Porokeratosis

Symptoms & Phenotypes for Punctate Porokeratosis

GenomeRNAi Phenotypes related to Punctate Porokeratosis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 MVD
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.83 MVD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.83 MVD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.83 MVD
5 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.83 PMVK
6 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.83 MVD
7 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.83 MVD
8 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.83 MVD
9 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.83 PMVK
10 Increased shRNA abundance (Z-score > 2) GR00366-A-66 9.83 PMVK
11 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.83 MVD
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.83 PMVK
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.83 MVD PMVK
14 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.83 MVD
15 Reduced mammosphere formation GR00396-S 8.92 FDPS MVD MVK PMVK

Drugs & Therapeutics for Punctate Porokeratosis

Drugs for Punctate Porokeratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ustekinumab Approved, Investigational Phase 3 815610-63-0
2 Dermatologic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Ustekinumab in the Treatment of Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)

Search NIH Clinical Center for Punctate Porokeratosis

Genetic Tests for Punctate Porokeratosis

Anatomical Context for Punctate Porokeratosis

MalaCards organs/tissues related to Punctate Porokeratosis:

40
T Cells, Colon, Liver

Publications for Punctate Porokeratosis

Articles related to Punctate Porokeratosis:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Accounting for Differential Item Functioning Using Bayesian Approximate Measurement Invariance. 61
32616953 2020
2
Punctate porokeratosis-pruritic and hyperkeratotic papules on the palms and feet. 61
32675969 2020
3
The Reactivity of Phosphanylphosphinidene Complexes of Transition Metals Toward Terminal Dihaloalkanes. 61
32216307 2020
4
Tripsazea, a Novel Trihybrid of Zea mays, Tripsacum dactyloides, and Zeaperennis. 61
31792004 2020
5
Marek's disease viruses circulating in commercial poultry in Italy in the years 2015-2018 are closely related by their meq gene phylogeny. 61
31411371 2020
6
Successful Treatment of Refractory Palmoplantar Pustular Psoriasis With Apremilast: A Case Series. 61
33178709 2020
7
Determination of Antioxidant and Antifungal Activities in Cookies Fortified with Solar Dried Prickly Pear Peels Powder. 61
32363815 2020
8
Full-length transcriptome sequences of Agropyron cristatum facilitate the prediction of putative genes for thousand-grain weight in a wheat-A. cristatum translocation line. 61
31881839 2019
9
Deletion mapping and verification of an enhanced-grain number per spike locus from the 6PL chromosome arm of Agropyron cristatum in common wheat. 61
31309244 2019
10
Molecular characterization of the meq gene of Marek's disease viruses detected in unvaccinated backyard chickens reveals the circulation of low- and high-virulence strains. 61
30850833 2019
11
In silico minimalist approach to study 2D HP protein folding into an inhomogeneous space mimicking osmolyte effect: First trial in the search of foldameric backbones. 61
31029589 2019
12
GD3 ganglioside-enriched extracellular vesicles stimulate melanocyte migration. 61
29908366 2019
13
Refractory Palmoplantar Pustular Psoriasis Treated With High-Dose Ustekinumab After Initial Failure. 61
30141337 2019
14
Exploring beliefs about pneumococcal vaccination in a predominantly older African American population: the Pharmacists' Pneumonia Prevention Program (PPPP). 61
30175602 2018
15
Knowledge, Activation, and Costs of the Pharmacists' Pneumonia Prevention Program (PPPP): A Novel Senior Center Model to Promote Vaccination. 61
29172664 2018
16
On-Surface Synthesis of Highly Oriented Thin Metal-Organic Framework Films through Vapor-Assisted Conversion. 61
29542320 2018
17
Physical Localization of a Locus from Agropyron cristatum Conferring Resistance to Stripe Rust in Common Wheat. 61
29137188 2017
18
Preparing Trainees for Integrated Care: Triple Board and the Postpediatric Portal Program. 61
28916008 2017
19
Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s. 61
28852040 2017
20
Chromosomal localization of genes conferring desirable agronomic traits from Agropyron cristatum chromosome 1P. 61
28394901 2017
21
Mapping of novel powdery mildew resistance gene(s) from Agropyron cristatum chromosome 2P. 61
27771744 2017
22
Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway. 61
27743912 2017
23
Expanding the Group of Porous Interpenetrated Zr-Organic Frameworks (PIZOFs) with Linkers of Different Lengths. 61
28032763 2017
24
Linear porokeratosis with multiple squamous cell carcinomas successfully treated by electrochemotherapy. 61
27086492 2016
25
An intercalary translocation from Agropyron cristatum 6P chromosome into common wheat confers enhanced kernel number per spike. 61
27246315 2016
26
Cytological and molecular analysis of wheat - Agropyron cristatum translocation lines with 6P chromosome fragments conferring superior agronomic traits in common wheat. 61
27643577 2016
27
Sequence analysis of Meq oncogene among Indian isolates of Marek's disease herpesvirus. 61
27617224 2016
28
Genetic analysis of a novel broad-spectrum powdery mildew resistance gene from the wheat-Agropyron cristatum introgression line Pubing 74. 61
27125388 2016
29
Porokeratosis ptychotropica: a rare manifestation with typical histological exam. 61
27579746 2016
30
Physical mapping of Agropyron cristatum chromosome 6P using deletion lines in common wheat background. 61
26920547 2016
31
Production and Identification of Wheat-Agropyron cristatum 2P Translocation Lines. 61
26731742 2016
32
Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris. 61
27152848 2016
33
Transferring Desirable Genes from Agropyron cristatum 7P Chromosome into Common Wheat. 61
27459347 2016
34
Design and improvement of artificial redox modules by molecular fusion of flavodoxin and flavodoxin reductase from Escherichia coli. 61
26177696 2015
35
The effects of chromosome 6P on fertile tiller number of wheat as revealed in wheat-Agropyron cristatum chromosome 5A/6P translocation lines. 61
25656149 2015
36
Punctate Porokeratosis Palmaris et Plantaris. 61
26120157 2015
37
The effects of glucuronic acid and N-acetyl-D-glucosamine on in vitro fertilisation of porcine oocytes. 61
25585197 2015
38
Conformational control of oligo(p-phenyleneethynylene)s with intrinsic substituent electronic effects: origin of the twist in pentiptycene-containing systems. 61
25212481 2014
39
Increased expression of IL-17A and limited involvement of IL-23 in patients with palmo-plantar (PP) pustular psoriasis or PP pustulosis; results from a randomised controlled trial. 61
24112799 2014
40
Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion. 61
24985558 2014
41
Coinage metal complexes supported by the tri- and tetraphosphine ligands. 61
24750114 2014
42
Genetic rearrangements of six wheat-agropyron cristatum 6P addition lines revealed by molecular markers. 61
24595330 2014
43
Polar localization of PhoN2, a periplasmic virulence-associated factor of Shigella flexneri, is required for proper IcsA exposition at the old bacterial pole. 61
24587292 2014
44
The more the merrier: recent hybridization and polyploidy in cardamine. 61
24082009 2013
45
Improved function in women with persistent pregnancy-related pelvic pain after a single corticosteroid injection to the ischiadic spine: a randomized double-blind controlled trial. 61
23713407 2013
46
Unilateral punctate porokeratosis -- case report. 61
23793192 2013
47
Efficacy of ustekinumab in refractory palmoplantar pustular psoriasis. 61
23210683 2013
48
The Active Straight Leg Raise test in lumbopelvic pain during pregnancy. 61
22365484 2012
49
Severity of signs and symptoms in lumbopelvic pain during pregnancy. 61
22248704 2012
50
Pathotyping of Australian isolates of Marek's disease virus and association of pathogenicity with meq gene polymorphism. 61
22515535 2012

Variations for Punctate Porokeratosis

Expression for Punctate Porokeratosis

Search GEO for disease gene expression data for Punctate Porokeratosis.

Pathways for Punctate Porokeratosis

GO Terms for Punctate Porokeratosis

Cellular components related to Punctate Porokeratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.8 PMVK MVK MVD

Biological processes related to Punctate Porokeratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.76 PMVK MVK MVD FDPS
2 steroid metabolic process GO:0008202 9.73 PMVK MVK MVD FDPS
3 cholesterol metabolic process GO:0008203 9.71 PMVK MVK MVD FDPS
4 steroid biosynthetic process GO:0006694 9.67 PMVK MVK MVD FDPS
5 cholesterol biosynthetic process GO:0006695 9.62 PMVK MVK MVD FDPS
6 regulation of cholesterol biosynthetic process GO:0045540 9.56 PMVK MVK MVD FDPS
7 isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 9.33 PMVK MVK MVD
8 sterol biosynthetic process GO:0016126 9.26 PMVK MVK MVD FDPS
9 isoprenoid biosynthetic process GO:0008299 8.92 PMVK MVK MVD FDPS

Sources for Punctate Porokeratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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