MCID: PPL023
MIFTS: 27

Pupil Disease

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Pupil Disease

MalaCards integrated aliases for Pupil Disease:

Name: Pupil Disease 12 15
Pupil Disorders 44 72
Pupillary Disorder 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:238
MeSH 44 D011681
SNOMED-CT 68 68633000
UMLS 72 C0034124

Summaries for Pupil Disease

MalaCards based summary : Pupil Disease, also known as pupil disorders, is related to neuropathy and syphilis, and has symptoms including seizures, vertigo and pain. An important gene associated with Pupil Disease is GDAP1 (Ganglioside Induced Differentiation Associated Protein 1). The drugs Dopamine and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Wikipedia : 75 The pupil is a black hole located in the center of the iris of the eye that allows light to strike the... more...

Related Diseases for Pupil Disease

Graphical network of the top 20 diseases related to Pupil Disease:



Diseases related to Pupil Disease

Symptoms & Phenotypes for Pupil Disease

UMLS symptoms related to Pupil Disease:


seizures, vertigo, pain, tonic pupil, mydriasis, eye manifestations, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations

Drugs & Therapeutics for Pupil Disease

Drugs for Pupil Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved 51-61-6, 62-31-7 681
2
Methamphetamine Approved, Illicit 537-46-2 10836
3
Desflurane Approved 57041-67-5 42113
4
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
5
Remifentanil Approved 132875-61-7 60815
6
Sevoflurane Approved, Vet_approved 28523-86-6 5206
7 Sympathomimetics
8 Neurotransmitter Agents
9 Dopamine Agents
10 Central Nervous System Stimulants
11 Adrenergic Agents
12 Neurotransmitter Uptake Inhibitors
13 Dopamine Uptake Inhibitors
14 Autonomic Agents
15 Analgesics
16 Narcotics
17 Peripheral Nervous System Agents
18 Anesthetics
19 Central Nervous System Depressants
20 Hypnotics and Sedatives
21 Platelet Aggregation Inhibitors
22 Anesthetics, General
23 Analgesics, Opioid
24 Anesthetics, Intravenous
25 Anesthetics, Inhalation

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Influence of Gaze Shift and Emotions on Symptoms of Blepharospasm- a Pilot Study. Unknown status NCT01759745
2 New Automatic Portable Ophthalmology Device Completed NCT02772666
3 Alternative Apnea Test as the Method of Brain Death Diagnosis . Completed NCT03281993
4 Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome Recruiting NCT02999659
5 Comparison of Effects of Volatile and Intravenous Anesthetics on Pupillary Function During General Anesthesia in Children; a Prospective, Observational, Randomized Controlled Trial. Not yet recruiting NCT03987529

Search NIH Clinical Center for Pupil Disease

Cochrane evidence based reviews: pupil disorders

Genetic Tests for Pupil Disease

Anatomical Context for Pupil Disease

MalaCards organs/tissues related to Pupil Disease:

41
Eye, Retina, Testes, Brain, Pineal

Publications for Pupil Disease

Articles related to Pupil Disease:

# Title Authors PMID Year
1
[Pupil disorders]. 38
30999363 2019
2
A cohort study on acute ocular motility disorders in pediatric emergency department. 38
29843812 2018
3
[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region]. 38
29927424 2018
4
[Ophthalmic complications and local anesthesia. Pathophysiology and types of eye complications after intraoral dental anesthesia, and clinical recommendations]. 38
25428546 2014
5
[Optic neuropathies and peripheral oculomotor disorders in patients with AIDS]. 38
9064185 1996
6
Influence of pupil size, anisocoria, and ambient light on pilocarpine miosis. Implications for supersensitivity testing. 38
8437838 1993

Variations for Pupil Disease

Expression for Pupil Disease

Search GEO for disease gene expression data for Pupil Disease.

Pathways for Pupil Disease

GO Terms for Pupil Disease

Biological processes related to Pupil Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelination GO:0042552 8.62 MPZ EGR2

Sources for Pupil Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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