Aliases & Classifications for Purpura

Summaries for Purpura

MalaCards based summary : Purpura, also known as purpuric disorder, is related to thrombocytopenic purpura, autoimmune and thrombotic thrombocytopenic purpura, and has symptoms including pruritus, hemoptysis and flushing. An important gene associated with Purpura is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying... more...

Related Diseases for Purpura

Diseases related to Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 886)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenic purpura, autoimmune 34.1 ITGA2B ITGB3 MPL THPO
2 thrombotic thrombocytopenic purpura 34.0 ADAMTS13 APOH F3 THBD VWF
3 purpura fulminans 33.6 F2 F3 PROC PROCR PROS1 SERPINC1
4 thrombocytopenia due to platelet alloimmunization 32.9 ITGA2B ITGB3 MPL THPO
5 proteasome-associated autoinflammatory syndrome 1 31.5 CRP IL6 TNF
6 fetal and neonatal alloimmune thrombocytopenia 31.3 GP1BB ITGA2B ITGB3
7 heparin-induced thrombocytopenia 30.8 CD79A F3 SERPINC1
8 von willebrand's disease 30.8 ADAMTS13 F2 F3 VWF
9 disseminated intravascular coagulation 30.8 ADAMTS13 F2 F3 SERPINC1 THBD
10 hemolytic-uremic syndrome 30.7 ADAMTS13 F3 THBD VWF
11 catastrophic antiphospholipid syndrome 30.6 ADAMTS13 APOH F3 PROC
12 prothrombin deficiency, congenital 30.6 APOH F2 SERPINC1
13 protein c deficiency 30.4 F2 PROC SERPINC1 THBD
14 vasculitis 30.4 APOH CRP THBD TNF VWF
15 thrombocytopenia 30.4 ADAMTS13 APOH F3 GP1BB ITGA2B ITGB3
16 bleeding disorder, platelet-type, 16 30.3 ITGA2B ITGB3
17 connective tissue disease 30.2 ADAMTS13 APOH IL6 TNF
18 meningococcemia 30.2 PROC PROCR SERPINC1 THBD
19 bernard-soulier syndrome 30.1 F2 GP1BB ITGA2B ITGB3 THPO VWF
20 meningitis 30.1 CRP IL6 TNF
21 qualitative platelet defect 30.1 F2 F3 VWF
22 mixed connective tissue disease 30.0 ADAMTS13 APOH IL6 TNF
23 glanzmann thrombasthenia 30.0 F2 F3 ITGA2B ITGB3 VWF
24 liver cirrhosis 30.0 F2 F3 SERPINC1 THPO
25 protein s deficiency 30.0 APOH F2 F3 PROS1 SERPINC1
26 polyarteritis nodosa 30.0 APOH CRP IL6
27 hemophilia 30.0 F2 F3 VWF
28 hemophilia b 29.9 F2 F3 SERPINC1
29 hemorrhagic disease 29.9 ADAMTS13 F2 F3 ITGA2B MPL SERPINC1
30 factor xi deficiency 29.9 F2 F3 SERPINC1 THBD
31 adult-onset still's disease 29.9 CRP IL6 TNF
32 kawasaki disease 29.9 CRP IL6 TNF
33 von willebrand disease, type 1 29.9 F2 F3 VWF
34 appendicitis 29.8 CRP IL6 TNF
35 antithrombin iii deficiency 29.8 APOH F2 SERPINC1
36 factor v deficiency 29.8 C4B F2 F3 VWF
37 autosomal dominant macrothrombocytopenia 29.8 GP1BB ITGA2B ITGB3
38 hemolytic uremic syndrome, atypical 1 29.8 ADAMTS13 C4B THBD VWF
39 factor xii deficiency 29.8 APOH F3 SERPINC1
40 autoimmune disease 29.8 APOH CD79A IL6 TNF
41 central retinal vein occlusion 29.8 APOH F2 IL6 SERPINC1
42 portal vein thrombosis 29.8 APOH F2 SERPINC1
43 coronary thrombosis 29.7 F3 ITGB3 SERPINC1 VWF
44 antiphospholipid syndrome 29.7 ADAMTS13 APOH F2 F3 SERPINC1 THBD
45 factor x deficiency 29.7 F2 F3 SERPINC1 VWF
46 afibrinogenemia, congenital 29.7 F2 F3 SERPINC1 VWF
47 acute myocardial infarction 29.7 CRP F3 ITGA2B SERPINC1 VWF
48 toxic shock syndrome 29.7 IL6 SERPINC1 TNF
49 retinal vein occlusion 29.7 APOH F2 IL6 SERPINC1
50 brucellosis 29.7 CRP IL6 TNF

Graphical network of the top 20 diseases related to Purpura:



Diseases related to Purpura

Symptoms & Phenotypes for Purpura

UMLS symptoms related to Purpura:


pruritus, hemoptysis, flushing, icterus, petechiae of skin, skin manifestations, integumentary system signs and symptoms

MGI Mouse Phenotypes related to Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 ADAMTS13 APOH C4B CD79A CRP F2
2 hematopoietic system MP:0005397 10.36 ADAMTS13 C4B CD79A F2 F3 GP1BB
3 cardiovascular system MP:0005385 10.32 C4B CRP F2 F3 IL6 ITGA2B
4 immune system MP:0005387 10.25 ADAMTS13 C4B CD79A CRP F2 F3
5 embryo MP:0005380 10.13 F2 F3 ITGA2B ITGB3 MPL PROCR
6 digestive/alimentary MP:0005381 10.06 C4B F2 IL6 ITGA2B ITGB3 THBD
7 mortality/aging MP:0010768 10.03 ADAMTS13 APOH C4B F2 F3 IL6
8 liver/biliary system MP:0005370 9.91 C4B CD79A IL6 ITGB3 PROC PROS1
9 nervous system MP:0003631 9.7 CD79A F2 F3 IL6 ITGB3 PROC
10 respiratory system MP:0005388 9.17 F2 F3 IL6 ITGB3 PROC THBD

Drugs & Therapeutics for Purpura

Drugs for Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 1177-87-3
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
5
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
8
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
9
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
10
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
17
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 104987-11-3 445643 439492
18
Vincristine Approved, Investigational Phase 4,Phase 2,Phase 3 57-22-7, 2068-78-2 5978
19
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
20
Hydroxychloroquine Approved Phase 4 118-42-3 3652
21
Clopidogrel Approved Phase 4,Phase 3 113665-84-2, 120202-66-6 60606
22
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
23
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
24
Methotrexate Approved Phase 4,Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
27
Caffeic acid Experimental, Investigational Phase 4,Phase 3 331-39-5 1549111
28
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable 2920-86-7
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Antioxidants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 BB 1101 Phase 4,Phase 3,Phase 2
41 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
42 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
43
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
44 Anti-Asthmatic Agents Phase 4
45 Betamethasone acetate Phase 4
46 Betamethasone benzoate Phase 4
47 Betamethasone Valerate Phase 4 2152-44-5
48 Respiratory System Agents Phase 4,Phase 1,Phase 2,Early Phase 1
49 Betamethasone-17,21-dipropionate Phase 4
50 Betamethasone sodium phosphate Phase 4

Interventional clinical trials:

(show top 50) (show all 386)
# Name Status NCT ID Phase Drugs
1 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
2 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
3 The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine Unknown status NCT02153866 Phase 4
4 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
5 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
6 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
7 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
8 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
9 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
10 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
11 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
12 Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands Completed NCT01910831 Phase 4 DerMend Moisturizing Bruise Formula
13 The Study of Different Dose Rituximab in the Treatment of ITP Completed NCT03258866 Phase 4 Rituximab;Rituximab
14 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
15 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
16 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Completed NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
17 VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel Completed NCT01684813 Phase 4 Prasugrel.;Clopidogrel
18 Pharmacogenetic Study in Patients With Relapsing Forms of Multiple Sclerosis Who Developed ITP After Receiving Lemtrada Recruiting NCT03784898 Phase 4 Alemtuzumab (GZ402673)
19 Atorvastatin in Management of Newly Diagnosed ITP Recruiting NCT03692754 Phase 4 Atorvastatin 20mg;Atorvastatin 10mg
20 Efficacy and Safety of rhTPO and Eltrombopag in Patients With Primary Immune Thrombocytopenia (ITP) Recruiting NCT03771378 Phase 4 rhTPO;eltrombopag
21 The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia Recruiting NCT03201848 Phase 4 Placebo;Huaiqihuang Granule
22 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4 romiplostim
23 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
24 A Rollover Study to Provide Continued Treatment With Eltrombopag Active, not recruiting NCT01957176 Phase 4 ELT
25 Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura Not yet recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
26 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
27 Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura Withdrawn NCT01754545 Phase 4 Octaplas infusion and placebo (group 1);Octaplas infusion and placebo (group 2)
28 Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP) Withdrawn NCT02642380 Phase 4 Dexamethasone (4 cycles);Dexamethasone (1 cycle)
29 Association of FcγRIIIA Polymorphism and THPO Expression With Response to Eltrombopag in Refractory ITP Patients Unknown status NCT02877212 Phase 3 Eltrombopag
30 Efficacy and Safety Study of Maintenance Treatment With rhTPO in Thrombocytopenic Subjects With ITP Unknown status NCT01805648 Phase 3 rhTPO
31 DEX Combined With RTX, CSA and IVIG in the Management of Newly Diagnosed ITP Patients Unknown status NCT02834468 Phase 3 DEX Combined With RTX, CSA and IVIG
32 Thrombocytopenia in Gestational Period Unknown status NCT02751593 Phase 2, Phase 3 Dexamethasone
33 A Multicenter Study on Recombinant Human Thrombopoietin in Management of ITP in Pregnancy Unknown status NCT02391272 Phase 3 rhTPO
34 Recombinant Human Thrombopoietin (rhTPO) in Management of Immune Thrombocytopenia (ITP) in Pregnancy Unknown status NCT02270801 Phase 3 rhTPO
35 Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia Unknown status NCT01763658 Phase 2, Phase 3 Antox tablets(Mepaco)
36 A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076399 Phase 3 Fostamatinib disodium;Placebo
37 A Efficacy and Safety Study of Fostamatinib in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT02076412 Phase 3 Fostamatinib Disodium;Placebo
38 A Long-term Safety Study of Eltrombopag in Pediatric Patients With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT02201290 Phase 3 Eltrombopag Tablets;Eltrombopag PfOS
39 A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune (Idiopathic) Thrombocytopenia Purpura Completed NCT01071954 Phase 3
40 P3 Study to Evaluate Efficacy and Safety of AMG 531 in Thrombocytopenic Japanese Subjects With Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00603642 Phase 3 Placebo;AMG 531
41 Treatment of Chronic Immune Thrombocytopenic Purpura (ITP) With Intravenous Immunoglobulin IgPro10 Completed NCT00168038 Phase 3
42 Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT00713193 Phase 3 Cyclosporine;Prednisone
43 Clinical Trial in Patients Diagnosed With Immune Thrombocytopenic Purpura Completed NCT00699140 Phase 3
44 The Efficacy of Dexamethasone Versus Dexamethasone Combined With Rituximab in Patients With Newly Diagnosed Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00909077 Phase 3 Dexamethasone;Dexamethasone and Rituximab
45 Clinical Study to Evaluate the Efficacy and Safety of Octagam 10% in Idiopathic Thrombocytopenic Purpura in Adults Completed NCT00426270 Phase 3 Octagam 10%
46 Ig NextGen 10% in Idiopathic Thrombocytopenic Purpura (ITP) Patients Completed NCT00362349 Phase 3 IgNextGen 10%
47 A Study to Find How Safe and Effective GAMMAPLEX® is in Subjects With Chronic Idiopathic Thrombocytopenic Purpura (ITP) Completed NCT00504075 Phase 3
48 Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura Completed NCT00657410 Phase 3 dexamethasone;prednisone
49 Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00415532 Phase 3 Medical Standard of Care for ITP
50 Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura Completed NCT02553317 Phase 3

Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: purpura

Genetic Tests for Purpura

Genetic tests related to Purpura:

# Genetic test Affiliating Genes
1 Purpura 29

Anatomical Context for Purpura

MalaCards organs/tissues related to Purpura:

41
Skin, T Cells, Bone, Bone Marrow, B Cells, Liver, Endothelial

Publications for Purpura

Articles related to Purpura:

(show top 50) (show all 5221)
# Title Authors Year
1
Acquired thrombotic thrombocytopenic purpura with isolated CFHR3/1 deletion-rapid remission following complement blockade. ( 29728803 )
2018
2
Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura. ( 29304523 )
2018
3
Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report. ( 29357939 )
2018
4
The clinical features of cardiac involvement in patients with severe thrombotic thrombocytopenic purpura. ( 29752524 )
2018
5
Acquired Versus Congenital Neonatal Purpura Fulminans: A Case Report and Literature Review. ( 29683961 )
2018
6
HLA-DRB1 gene polymorphisms in Iranian children with Henoch-SchAPnlein purpura. ( 29937904 )
2018
7
Purpura fulminans causing acute cortical necrosis in postpartum period. ( 29593006 )
2018
8
Integrated Network Pharmacology and Metabolomics Analysis of the Therapeutic Effects of Zi Dian Fang on Immune Thrombocytopenic Purpura. ( 29971001 )
2018
9
Adult onset immunoglobulin A vasculitis (Henoch-Schonlein purpura) with alveolar hemorrhage. ( 29942747 )
2018
10
Pediatric thrombotic thrombocytopenic purpura. ( 29889319 )
2018
11
Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13. ( 29763513 )
2018
12
Comparing immunoglobulin A vasculitis (Henoch-SchAPnlein purpura) in children and adults: a single-centre study from Turkey. ( 29912602 )
2018
13
Large vessel stroke as initial presentation of thrombotic thrombocytopenic purpura. ( 29437728 )
2018
14
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. ( 29630665 )
2018
15
A novel compound heterozygous mutations in protein C gene causing neonatal purpura fulminans. ( 29356699 )
2018
16
Correction to: Henoch-SchAPnlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. ( 29380166 )
2018
17
Pigmented purpura masquerading as acral melanoma. ( 29974454 )
2018
18
What We Know about Henoch-SchAPnlein Purpura in Children up to Date? ( 29915528 )
2018
19
ADAMTS13 Testing Methodologies and Thrombotic Thrombocytopenic Purpura (TTP): Conflicting Results Can Pose a Clinical Dilemma. ( 29970443 )
2018
20
Dynamic dosing of romiplostim in patients with immune thrombocytopenia purpura: Two case reports. ( 29357781 )
2018
21
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with BehAset's Disease. ( 29313056 )
2018
22
Odontogenic focal infection is a possible trigger of severe Henoch-SchAPnlein purpura nephritis. ( 29446581 )
2018
23
Two Cases of Israeli Spotted Fever with Purpura Fulminans, Sharon District, Israel. ( 29664383 )
2018
24
Post-Partum Thrombotic Thrombocytopenic Purpura (TTP) in a Patient with known Idiopathic (Immune) Thrombocytopenic Purpura: a case report and review of the literature. ( 29855343 )
2018
25
Sequential occurrence of Graves' disease and immune thrombocytopenic purpura as manifestations of immune reconstitution inflammatory syndrome in an HIV-infected patient. ( 29361886 )
2018
26
Rare presentation of rickettsial infection as purpura fulminans: a case report. ( 29801512 )
2018
27
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
28
An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura. ( 29222940 )
2018
29
Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency. ( 29540648 )
2018
30
Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease. ( 29961815 )
2018
31
Acute infectious purpura fulminans secondary to a dog bite. ( 29437318 )
2018
32
Cellular expression of CD markers in immune thrombocytopenic purpura: implications for prognosis. ( 29924452 )
2018
33
Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. ( 29725652 )
2018
34
The role of T cells in the development of Henoch-Schonlein purpura. ( 28930575 )
2018
35
Case of atopic dermatitis concurrent with idiopathic thrombocytopenic purpura, whose serum thymus and activation-regulated chemokine level remained undetectable. ( 29399856 )
2018
36
Pathophysiology of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. ( 29356300 )
2018
37
Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-SchOsnlein Purpura in Korea. ( 29915525 )
2018
38
Ticagrelor-induced thrombotic thrombocytopenic purpura: A case report and review of the literature. ( 29952973 )
2018
39
Myocardial Infarction as an Early Presentation in Thrombotic Thrombocytopenic Purpura: A Rare Case Series. ( 29761111 )
2018
40
Changes in plasma von Willebrand factor and von Willebrand factor cleaving protease in thrombotic thrombocytopenic purpura: A case report. ( 29250148 )
2018
41
No recurrence of nivolumab-induced idiopathic thrombocytopenic purpura in a metastatic melanoma patient switched to ipilimumab. ( 29400292 )
2018
42
Intravenous immunoglobulin as salvage therapy for refractory thrombotic thrombocytopenic purpura. ( 29247542 )
2018
43
Periumbilical purpura: dermatoscopic findings in disseminated strongyloidiasis. ( 29740812 )
2018
44
The Diagnostic Challenge of Acquired Thrombotic Thrombocytopenic Purpura in Children: Case Report and Review of the Literature. ( 29659973 )
2018
45
Pulmonary renal syndrome in Henoch-SchAPnlein purpura. ( 29967131 )
2018
46
Neuro-Behcet's disease in a patient with thrombotic thrombocytopenic purpura. ( 29444324 )
2018
47
Genetics of immunoglobulin-A vasculitis (Henoch-SchAPnlein purpura): An updated review. ( 29353097 )
2018
48
Onset of type 1 diabetes mellitus and heparin-induced thrombocytopenia in a patient with Basedow's disease and idiopathic thrombocytopenic purpura: Novel combination as autoimmune polyglandular syndrome. ( 29905024 )
2018
49
Does this patient with thrombotic thrombocytopenic purpura have a cardiac involvement? ( 29868970 )
2018
50
Idiopathic thrombocytopenic purpura in a patient with IgG4-related disease. ( 29888414 )
2018

Variations for Purpura

Expression for Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for Purpura

Pathways related to Purpura according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 APOH F2 F3 GP1BB ITGA2B ITGB3
2
Show member pathways
12.71 F2 F3 PROC PROS1 SERPINC1 THBD
3
Show member pathways
12.21 CRP F2 IL6 TNF
4
Show member pathways
12.16 F2 ITGB3 PROC PROCR PROS1 THBD
5
Show member pathways
12.11 IL6 ITGA2B ITGB3 TNF
6
Show member pathways
12.02 GP1BB ITGA2B ITGB3 VWF
7 11.98 ITGA2B ITGB3 THBD TNF
8 11.93 CD79A IL6 ITGA2B ITGB3 MPL THPO
9 11.91 GP1BB ITGA2B ITGB3 VWF
10 11.83 GP1BB IL6 ITGA2B ITGB3 THPO TNF
11
Show member pathways
11.81 F2 F3 GP1BB PROC PROCR PROS1
12 11.79 F3 IL6 THBD TNF
13
Show member pathways
11.79 F2 GP1BB ITGA2B ITGB3 MPL THPO
14 11.74 F3 ITGB3 VWF
15 11.66 C4B IL6 TNF
16 11.64 IL6 THBD TNF
17 11.61 IL6 ITGB3 TNF
18 11.51 F2 GP1BB ITGA2B ITGB3 VWF
19 11.42 IL6 ITGA2B ITGB3
20 11.42 C4B F2 F3 PROC PROCR PROS1
21 10.93 CRP IL6 TNF
22 10.92 IL6 ITGA2B ITGB3 THPO TNF
23 10.81 F2 PROC PROS1
24 10.73 GP1BB VWF
25 10.61 GP1BB VWF

GO Terms for Purpura

Cellular components related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.81 ADAMTS13 APOH F3 ITGA2B ITGB3 MPL
2 extracellular region GO:0005576 9.8 ADAMTS13 APOH C4B CRP F2 F3
3 endoplasmic reticulum lumen GO:0005788 9.72 ADAMTS13 F2 IL6 PROC SERPINC1
4 blood microparticle GO:0072562 9.65 C4B F2 ITGA2B PROS1 SERPINC1
5 extracellular space GO:0005615 9.47 ADAMTS13 APOH C4B CRP F2 F3
6 plasma membrane GO:0005886 10.18 C4B CD79A F2 F3 GP1BB ITGA2B
7 extracellular exosome GO:0070062 10.06 APOH C4B F2 ITGA2B ITGB3 PROCR

Biological processes related to Purpura according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.91 CD79A F2 GP1BB MPL
2 cellular protein metabolic process GO:0044267 9.87 F2 IL6 PROC SERPINC1
3 extracellular matrix organization GO:0030198 9.86 ITGA2B ITGB3 TNF VWF
4 positive regulation of protein phosphorylation GO:0001934 9.84 F2 ITGB3 THPO TNF
5 platelet degranulation GO:0002576 9.8 APOH ITGA2B ITGB3 PROS1 VWF
6 cell-matrix adhesion GO:0007160 9.79 ADAMTS13 ITGA2B ITGB3
7 integrin-mediated signaling pathway GO:0007229 9.79 ADAMTS13 ITGA2B ITGB3
8 platelet activation GO:0030168 9.73 ADAMTS13 F2 GP1BB IL6 ITGB3 VWF
9 blood coagulation GO:0007596 9.7 ADAMTS13 F2 F3 GP1BB ITGB3 PROC
10 platelet aggregation GO:0070527 9.69 ITGA2B ITGB3 MPL
11 blood coagulation, intrinsic pathway GO:0007597 9.67 APOH F2 GP1BB VWF
12 acute-phase response GO:0006953 9.65 CRP F2 IL6
13 regulation of blood coagulation GO:0030193 9.63 APOH F2 SERPINC1
14 negative regulation of blood coagulation GO:0030195 9.62 APOH PROC PROS1 THBD
15 negative regulation of fibrinolysis GO:0051918 9.61 APOH F2 THBD
16 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.6 CRP ITGB3
17 positive regulation of blood coagulation GO:0030194 9.59 APOH F2
18 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
19 opsonization GO:0008228 9.58 C4B CRP
20 negative regulation of coagulation GO:0050819 9.55 PROC PROCR
21 positive regulation of neuroinflammatory response GO:0150078 9.52 IL6 TNF
22 thrombopoietin-mediated signaling pathway GO:0038163 9.49 MPL THPO
23 negative regulation of lipid storage GO:0010888 9.46 CRP IL6 ITGB3 TNF
24 hemostasis GO:0007599 9.32 ADAMTS13 F2 F3 GP1BB PROC PROCR

Molecular functions related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.73 ADAMTS13 CRP F2 PROC PROS1 THBD
2 serine-type endopeptidase activity GO:0004252 9.71 C4B F2 F3 PROC
3 transmembrane signaling receptor activity GO:0004888 9.67 CD79A GP1BB MPL THBD
4 identical protein binding GO:0042802 9.56 APOH CRP GP1BB ITGA2B ITGB3 SERPINC1
5 fibrinogen binding GO:0070051 9.16 ITGA2B ITGB3
6 protease binding GO:0002020 9.02 F3 ITGB3 SERPINC1 TNF VWF
7 protein binding GO:0005515 10.25 ADAMTS13 APOH CD79A CRP F2 F3

Sources for Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....