Aliases & Classifications for Purpura

Summaries for Purpura

MalaCards based summary : Purpura, also known as purpuric disorder, is related to henoch-schoenlein purpura and thrombotic thrombocytopenic purpura, and has symptoms including pruritus, hemoptysis and flushing. An important gene associated with Purpura is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Lansoprazole and Dexlansoprazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Purpura (/ˈpɜːrpjʊərə/) is a condition of red or purple discolored spots on the skin that do not blanch... more...

Related Diseases for Purpura

Diseases related to Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1595)
# Related Disease Score Top Affiliating Genes
1 henoch-schoenlein purpura 34.8 CRP CD79A CD40LG
2 thrombotic thrombocytopenic purpura 33.5 VWF THBD SERPINC1 ITGB3 F3 CD40LG
3 thrombocytopenic purpura, autoimmune 33.5 THPO MPL ITGB3 ITGA2B GP1BA CD40LG
4 purpura fulminans 33.4 THBD SERPINC1 PROS1 PROC F3 F2
5 thrombotic microangiopathy 33.2 VWF ADAMTS13
6 evans' syndrome 32.6 THPO MPL CD40LG ADAMTS13
7 hypersensitivity vasculitis 32.5 TNF IL6 CRP CD40LG
8 adult-onset still's disease 32.5 TNF IL6 CRP
9 thrombocytopenia due to platelet alloimmunization 32.4 TNFSF13B THPO MPL ITGB3 ITGA2B GP1BA
10 fetal and neonatal alloimmune thrombocytopenia 32.4 ITGB3 ITGA2B GP1BA
11 protein c deficiency 32.4 THBD SERPINC1 PROC F2 APOH
12 proteasome-associated autoinflammatory syndrome 1 32.2 TNF IL6 CRP
13 protein s deficiency 31.7 THBD SERPINC1 PROS1 PROC F3 F2
14 heparin-induced thrombocytopenia 31.4 SERPINC1 F3 CD40LG
15 intussusception 31.1 IL6 CRP CD40LG
16 meningococcemia 31.0 THBD SERPINC1 PROC
17 qualitative platelet defect 31.0 VWF THPO F3 F2
18 rubella 30.9 TNF IL6 CD40LG
19 al amyloidosis 30.9 VWF ADAMTS13
20 acquired von willebrand syndrome 30.9 VWF GP1BA F3 ADAMTS13
21 chickenpox 30.9 TNF IL6 CRP CD40LG
22 factor vii deficiency 30.9 SERPINC1 F3 F2
23 mumps 30.9 TNF IL6 CD40LG
24 factor viii deficiency 30.9 VWF F3 F2
25 raynaud phenomenon 30.9 VWF THBD APOH
26 malignant hypertension 30.8 VWF THBD ADAMTS13
27 gray platelet syndrome 30.8 VWF THPO ITGA2B GP1BA CD40LG
28 macroglobulinemia 30.8 TNFSF13B IL6 CD40LG
29 von willebrand's disease 30.8 VWF ITGB3 GP1BA F3 F2 ADAMTS13
30 catastrophic antiphospholipid syndrome 30.8 PROC F3 CD40LG APOH ADAMTS13
31 mesangial proliferative glomerulonephritis 30.7 IL6 CD79A CD40LG
32 factor xiii deficiency 30.7 VWF SERPINC1 F3 F2
33 hemophilia b 30.7 VWF SERPINC1 F3 F2
34 end stage renal disease 30.7 TNF THBD IL6 CRP
35 rheumatic fever 30.7 TNF IL6 CD40LG
36 guillain-barre syndrome 30.7 TNF CD79A CD40LG
37 factor xii deficiency 30.6 VWF SERPINC1 F3 APOH
38 afibrinogenemia, congenital 30.6 VWF SERPINC1 F3 F2
39 brucellosis 30.6 TNF IL6 CRP CD40LG
40 cryofibrinogenemia 30.6 CD79A CD40LG
41 hemolytic uremic syndrome, atypical 1 30.6 VWF THBD F3 ADAMTS13
42 von willebrand disease, type 2 30.6 VWF GP1BA ADAMTS13
43 immune deficiency disease 30.6 TNFSF13B TNF IL6 CD79A CD40LG
44 von willebrand disease, type 3 30.6 VWF GP1BA ADAMTS13
45 appendicitis 30.6 TNF IL6 CRP
46 polyarteritis nodosa 30.6 IL6 CRP APOH
47 diarrhea 30.6 TNF THBD IL6 CD40LG ADAMTS13
48 deficiency anemia 30.6 TNF THPO SERPINC1 IL6 CRP
49 tonsillitis 30.5 TNF IL6 CD79A
50 agammaglobulinemia 30.5 TNF IL6 CD79A CD40LG

Graphical network of the top 20 diseases related to Purpura:



Diseases related to Purpura

Symptoms & Phenotypes for Purpura

UMLS symptoms related to Purpura:


pruritus, hemoptysis, flushing, icterus, petechiae of skin, skin manifestations, integumentary system signs and symptoms

MGI Mouse Phenotypes related to Purpura:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.32 ADAMTS13 CD40LG CD79A F2 F3 GP1BA
2 homeostasis/metabolism MP:0005376 10.3 ADAMTS13 APOH CD40LG CD79A CRP F2
3 cardiovascular system MP:0005385 10.27 CD40LG CRP F2 F3 IL6 ITGA2B
4 cellular MP:0005384 10.25 CD40LG CD79A F2 F3 GP1BA IL6
5 immune system MP:0005387 10.19 ADAMTS13 CD40LG CD79A CRP F2 F3
6 embryo MP:0005380 10.06 F2 F3 ITGA2B ITGB3 MPL PROS1
7 mortality/aging MP:0010768 9.86 ADAMTS13 APOH CD40LG CD79A F2 F3
8 liver/biliary system MP:0005370 9.76 CD79A IL6 ITGB3 PROC PROS1 SERPINC1
9 nervous system MP:0003631 9.44 CD40LG CD79A F2 F3 IL6 ITGA2B

Drugs & Therapeutics for Purpura

Drugs for Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 268)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
2
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
3
alemtuzumab Approved, Investigational Phase 4 216503-57-0
4
Vincristine Approved, Investigational Phase 4 57-22-7, 2068-78-2 5978
5
Morphine Approved, Investigational Phase 4 57-27-2 5288826
6
Hydroxychloroquine Approved Phase 4 118-42-3 3652
7
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
8
rituximab Approved Phase 4 174722-31-7 10201696
9
Clarithromycin Approved Phase 4 81103-11-9 84029
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
12
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
13
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
14 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
15
leucovorin Approved Phase 4 58-05-9 6006 143
16
glycyrrhizin Approved, Experimental Phase 4 1405-86-3 3495
17
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
19
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
20
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
21
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 5280453 134070
22
Caffeic acid Experimental, Investigational Phase 4 501-16-6, 331-39-5 1549111
23
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
24
Enoxolone Investigational Phase 4 471-53-4 18526330
25 Antacids Phase 4
26 Anti-Ulcer Agents Phase 4
27 Proton Pump Inhibitors Phase 4
28 Antiprotozoal Agents Phase 4
29 Antiparasitic Agents Phase 4
30 Antioxidants Phase 4
31 Tubulin Modulators Phase 4
32 Antimalarials Phase 4
33 Antimitotic Agents Phase 4
34 retinol Phase 4
35 Retinol palmitate Phase 4
36 Arnica Phase 4
37 Antibodies Phase 4
38 Immunoglobulins, Intravenous Phase 4
39 Immunoglobulins Phase 4
40 Antineoplastic Agents, Immunological Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Cytochrome P-450 CYP3A Inhibitors Phase 4
43 Methylprednisolone Acetate Phase 4
44 Neuroprotective Agents Phase 4
45 Protective Agents Phase 4
46 Antimetabolites Phase 4
47 Folic Acid Antagonists Phase 4
48 Vitamin B Complex Phase 4
49 Folate Phase 4
50 Vitamin B9 Phase 4

Interventional clinical trials:

(show top 50) (show all 466)
# Name Status NCT ID Phase Drugs
1 The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine Unknown status NCT02153866 Phase 4
2 A Longitudinal 2-year Bone Marrow Study of Eltrombopag Olamine (SB-497115-GR) in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
3 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
4 A Prospective, Phase IV, Open-Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects Receiving Romiplostim for the Treatment of Thrombocytopenia Associated With Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
5 Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety Completed NCT03222687 Phase 4 tacrolimus;prednisone
6 High-dose Dexamethasone and Conventional Dose Prednisone, for the First-line Treatment of Adults With ITP: a Multicenter, Randomized Controlled, Clinical Trial Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
7 The Clinical Randomized Controlled Study of Different Dose Rituximab in the Treatment of Primary Immune Thrombocytopenia Completed NCT03258866 Phase 4 Rituximab;Rituximab
8 An Open-label, Prospective, Multicenter Study to Investigate the Specificity of in Vivo Antibody Binding to Red Blood Cells in Subjects With Chronic Immune Thrombocytopenic Purpura (ITP) Treated With IgPro10 (Privigen®) Who Have Shown Signs of Hemolysis Completed NCT01390649 Phase 4
9 Collection of Blood Samples From Patients With Relapsing Forms of Multiple Sclerosis (RMS) Who Have Developed Immune Thrombocytopenic Purpura (ITP) After LEMTRADA® Treatment Completed NCT03784898 Phase 4
10 Assessment of Platelet Function in Patients With Chronic Autoimmune Thrombocytopenic Purpura (cAITP) Treated With the Thrombopoietin Receptor (MPL) Agonist Eltrombopag. Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
11 Multicenter, Randomized, Open, Parallel Controlled Trials Evaluating the Efficacy and Safety of Different Human Thrombopoietin (rhTPO) Regimens in the Treatment of Patients With Primary Immune Thrombocytopenia (ITP) Completed NCT04089267 Phase 4 TPO
12 Thrombopoietin-receptor Agonist-immunomodulation in Young Adult Primary Immune Thrombocytopenia (ITP): A Multi-center Open Label Trial With Romiplostim Completed NCT02760251 Phase 4 romiplostim
13 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
14 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Completed NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
15 Randomized, Double-Blind, Contralateral, Controlled Study to Assess the Efficacy of DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Mature Skin of the Forearms and Hands Completed NCT01910831 Phase 4 DerMend Moisturizing Bruise Formula;Non-active placebo control
16 A Prospective, Multicenter, Placebo Controlled Study on Caffeic Acid Tablet Combining High-dose Dexamethasone in Management of Adult Primary Immune Thrombocytopenia (ITP) Completed NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
17 Influence of Plasma Exchange Therapy on the Pharmacokinetics of Rituximab in Patients Treated for Autoimmune Disorders. Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
18 A Randomized Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4 Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
19 Effects of Helicobacter Pylori Eradication Therapy in Children With Chronic Immune Thrombocytopenic Purpura Recruiting NCT03172676 Phase 4 Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.;Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.;Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
20 Post-Marketing Study to Evaluate the Efficacy and Safety of PANZYGA in Pediatric Patients With Chronic Immune Thrombocytopenia (ITP) Recruiting NCT03866798 Phase 4
21 A Single-center Prospective Randomized Study of Atorvastatin in the Treatment of Newly Diagnosed Primary Immune Thrombocytopenia (ITP) Recruiting NCT03692754 Phase 4 Atorvastatin 20mg;Atorvastatin 10mg
22 A Single-center Prospective Randomized Study of Glycyrrhetinic Acid Combined With Dexamethasone in the Treatment of Newly Diagnosed Primary Immune Thrombocytopenia (ITP) Recruiting NCT03998982 Phase 4 Glycyrrhetinic Acid;Dexamethasone
23 A Multisite, Randomized, Double-Blind, Placebo-Controlled, and Parallel Study to Evaluate the Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia (Qi Yin Deficiency) Recruiting NCT03201848 Phase 4 Placebo;Huaiqihuang Granule
24 Treatment With Thrombopoietin Mimetic Plus Immunosuppressive Therapy in Egyptian Patients With Aplastic Anaemia Recruiting NCT03896971 Phase 4 Combination of thrombopoietin mimetic and cyclosporin A
25 Efficacy and Safety of rhTPO and Eltrombopag in the Treatment of Chinese Adults With Primary Immune Thrombocytopenia (ITP):a Multicenter, Double-blind, Randomized, Controlled Trial Recruiting NCT03771378 Phase 4 rhTPO;eltrombopag
26 Randomized Clinical Trial of the Use of Eltrombopag in Children With Idiopathic Aplastic Anemia Recruiting NCT03243656 Phase 4 Eltrombopag
27 Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
28 Study 200170: A Rollover Study to Provide Continued Treatment With Eltrombopag Active, not recruiting NCT01957176 Phase 4 ELT
29 Efficacy of Eltrombopag in Chronic Immune Thrombocytopenia in Pediatrics Not yet recruiting NCT04102033 Phase 4 Eltrombopag
30 A Multicenter Randomized Open-label Clinical Trial of Vitamin D Combined With HD-DXM Versus HD-DXM for the Treatment of ITP Not yet recruiting NCT04094805 Phase 4 Rocaltrol;Dexamethasone
31 Protocol for a Randomized, Placebo-Controlled, Double-Blinded Trial to Study the Effects of Supplementary Omega-3 Fatty Acids on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
32 Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura Withdrawn NCT01754545 Phase 4 Octaplas infusion and placebo (group 1);Octaplas infusion and placebo (group 2)
33 Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP): a Prospective, Randomized Controlled Trial Withdrawn NCT02642380 Phase 4 Dexamethasone (4 cycles);Dexamethasone (1 cycle)
34 AN OPEN-LABEL TRIAL OF REDUCED- DOSE PYLERA (BISMUTH, METRONIDAZOLE, TETRACYCLINE), AMOXICILLIN, AND ESOMEPRAZOLE IN THE TREATMENT OF HELICOBACTER PYLORI INFECTION Withdrawn NCT02045251 Phase 4 Pylera based reduced regimen
35 Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn Withdrawn NCT03007381 Phase 4 Ketorolac Tromethamine;Normal Saline
36 Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care: Multicentric Randomized Controlled Trial Unknown status NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
37 Association of FC Gamma RIIIA Polymorphism and Thrombopoietin (THPO) Expression With Response to TPO Agonists in Refractory ITP and the Impact of Therapy on B and T Cells Subsets in the Patients With Mutated Genotypes Unknown status NCT02877212 Phase 3 Eltrombopag
38 A Multicenter, Single-Arm, Open Label Study Evaluating the Efficacy and Safety of Maintenance Treatment With Recombinant Human Thrombopoietin in Thrombocytopenic Subjects With Immune Thrombocytopenia Unknown status NCT01805648 Phase 3 rhTPO
39 A Multicenter, Open-Label, Phase III Study to Evaluate the Efficacy and Safety of LIV-GAMMA SN Inj. in Primary Immune Thrombocytopenia (ITP) Unknown status NCT03164915 Phase 3
40 Thrombocytopenia in Gestational Period Unknown status NCT02751593 Phase 2, Phase 3 Dexamethasone
41 Evaluation of Oxidant Status in Patients With Immune Thrombocytopenia (ITP) and the Role of an Adjuvant Antioxidant Therapy Unknown status NCT01763658 Phase 2, Phase 3 Antox tablets(Mepaco)
42 A Multicenter Randomized Study of Dexamethasone Combined With Rituximab, Cyclosporin and Intravenous Immunoglobulin in the Management of Newly Diagnosed ITP Patients Unknown status NCT02834468 Phase 3 DEX Combined With RTX, CSA and IVIG
43 Recombinant Human Thrombopoietin (rhTPO) in Management of Immune Thrombocytopenia (ITP)in Pregnancy: a Single-center Clinical Trial Unknown status NCT02270801 Phase 3 rhTPO
44 Prospective Multicenter Randomized Open-label Controlled Trial Assessing Efficacy and Safety of DAPSone as a Second-line Option in Adult Immune Thrombocytopenia Unknown status NCT02627417 Phase 3 Dapsone (Disulone®);Prednisone (Cortancyl®) alone followed by monitoring and "standard of care";Prednisone (Cortancyl®)
45 Proof of Concept; A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia Unknown status NCT03520049 Phase 3 Oseltamivir;Placebo
46 Transfusion of Plasma Prior to Invasive Procedures Pilot Trial (TOPPIT) Unknown status NCT02561026 Phase 3
47 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura Completed NCT02076399 Phase 3 Fostamatinib disodium;Placebo
48 An Open Label Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Completed NCT01071954 Phase 3
49 A Randomized, Double Blind, Placebo Controlled Phase 3 Study Evaluating the Efficacy and Safety of AMG 531 in Thrombocytopenic Japanese Subjects With Immune (Idiopathic) Thrombocytopenic Purpura Completed NCT00603642 Phase 3 Placebo;AMG 531
50 A Randomized, Open-label Study of First-line Treatment With Dexamethasone or Dexamethasone Plus MabThera on Sustained Treatment Response in Adult Patients With Idiopathic Thrombocytopenic Purpura Completed NCT00770562 Phase 3 rituximab;Dexamethasone

Search NIH Clinical Center for Purpura

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Epoprostenol
Epoprostenol Sodium

Genetic Tests for Purpura

Anatomical Context for Purpura

MalaCards organs/tissues related to Purpura:

40
Skin, Bone, Bone Marrow, Spleen, T Cells, Kidney, Liver

Publications for Purpura

Articles related to Purpura:

(show top 50) (show all 22502)
# Title Authors PMID Year
1
Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura. 61 54
20056836 2010
2
Henoch-Schönlein nephritis associated with streptococcal infection and persistent hypocomplementemia: a case report. 54 61
20181224 2010
3
[Henoch-Shönlein purpura]. 54 61
19345173 2009
4
Vasculitic IgA nephropathy: prognosis and outcome. 54 61
19342865 2009
5
Childhood Henoch-Schonlein nephritis: a multivariate analysis of clinical features and renal morphology at disease onset. 61 54
19377254 2009
6
Familial clusturing of Henoch-Schönlein purpura or IgA nephropathy: genetic background or environmental triggers? 61 54
19067882 2008
7
IgA nephropathy and Henoch-Schönlein purpura nephritis. 61 54
18332712 2008
8
The diagnostic value of IgA deposition in Henoch-Schönlein purpura. 54 61
18304186 2008
9
Splenic peliosis in the course of IgA nephropathy. 54 61
17885767 2007
10
Renal involvement in Henoch-Schönlein purpura: a multivariate analysis of initial prognostic factors. 54 61
17551657 2007
11
Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schönlein-Henoch purpura nephritis. 54 61
17699418 2007
12
Thrombopoietin and interleukin-6 levels in Henoch-Schönlein purpura. 61 54
17164950 2006
13
Fatal relapse of thrombotic thrombocytopaenic purpura after cardiac surgery in patient with congenital absence of vWF-cleaving protease activity. 54 61
16421154 2006
14
Thrombotic thrombocytopaenic purpura in HIV-infected patients. 54 61
16105187 2005
15
[Effect of danshao granule on serum superoxide dismutase activity and malonyldialdehyde content in children with Henoch-Schonlein purpura nephritis]. 54 61
14714360 2003
16
A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura. 61 54
12656756 2003
17
Immunoglobulin A-associated lymphocytic vasculopathy: a clinicopathologic study of eight patients. 61 54
12453297 2002
18
Acute glomerulonephritis. 61 54
10798062 1999
19
IgA nephropathy--human disease and animal model. 54 61
9154653 1997
20
Schönlein-Henoch purpura in adult patients. Predictive factors for IgA glomerulonephritis in a retrospective study of 57 cases. 61 54
9126006 1997
21
Hypergammaglobulinemic purpura associated with Sjögren's syndrome and chronic C type hepatitis. 54 61
9046734 1997
22
Inherited prethrombotic disorders and infectious purpura. 54 61
8822583 1996
23
Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. 54 61
8639762 1996
24
IgA-associated renal diseases. 54 61
8744534 1996
25
Serum anti-streptococcal IgA, IgG and IgM antibodies in IgA-associated diseases. 61 54
8503268 1993
26
Heavy and light chain composition of serum IgA and IgA rheumatoid factor in Henoch-Schönlein purpura. 61 54
1445457 1992
27
Protein C and S deficiency in severe infectious purpura of children: a collaborative study of 40 cases. 61 54
1430582 1992
28
Regional variation in C4 phenotype in patients with IgA nephropathy. 54 61
2329414 1990
29
[Schönlein-Henoch purpura and IgA nephropathy. A common pathogenetic cause?]. 61 54
2327670 1990
30
Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment. 61
32338586 2020
31
Atypical presentation of congenital thrombotic thrombocytopenic purpura with large and small vessel disease: A case report. 61
32472955 2020
32
Henoch-schönlein Purpura (HSP) in a patient on Abemaciclib. 61
32512359 2020
33
Predictors of In-Hospital Mortality in Thrombotic Thrombocytopenic Purpura in Children in the United States: A Population Analysis. 61
32011563 2020
34
Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis. 61
32455005 2020
35
Chronic paronychia with subungual purpura. 61
30829296 2020
36
Capnocytophagia canimorsus - Severe sepsis in a previously well individual with no evidence of a cat or dog bite. A case report. 61
32461803 2020
37
Air bubbles in the brain: retrograde venous gas embolism in the cavernous sinus. 61
32547668 2020
38
Immune thrombocytopenic purpura risk by live, inactivated and simultaneous vaccinations among Japanese adults, children and infants: a matched case-control study. 61
32253664 2020
39
Heterogeneity of diagnosis, treatment, and management for immune thrombotic thrombocytopenic purpura: Are we still peering through the looking glass? 61
32449953 2020
40
Idiopathic thrombocytopenic purpura treatment in a relapsed/refractory multiple myeloma patient after chimeric antigen receptor T cell therapy. 61
32455157 2020
41
Eltrombopag treatment promotes platelet recovery and reduces platelet transfusion for patients with post-transplantation thrombocytopenia. 61
32519094 2020
42
Blood Cell Disorders and the Nervous System. 61
32487901 2020
43
Fatal Intracerebral Hemorrhage During "Muay Thai" in a 21-Year-Old Man With Undiagnosed Acute Myeloid Leukemia: Spontaneous or Posttraumatic Hemorrhage? 61
32541393 2020
44
Population-based studies in systemic lupus erythematosus: immune thrombocytopenic purpura or 'blood-dominant' lupus? 61
32312772 2020
45
Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a population-based cohort study. 61
32241798 2020
46
Severe primary refractory thrombotic thrombocytopenic purpura (TTP) in the post plasma exchange (PEX) and rituximab era. 61
32532908 2020
47
Thrombotic thrombocytopenic purpura associated with AIDS: challenges in diagnosis and management. 61
32379160 2020
48
Congenital thrombotic thrombocytopenic purpura (TTP) with placental abruption despite maternal improvement: a case report. 61
32539690 2020
49
Efficacy of albumin and compounded plasma for plasma exchange in acquired thrombotic thrombocytopenic purpura. 61
32110837 2020
50
Hereditary Thrombotic Thrombocytopenic Purpura in a 9-Month Old: Diagnosing and Managing an Ultra-rare Disorder. 61
32496441 2020

Variations for Purpura

Expression for Purpura

Search GEO for disease gene expression data for Purpura.

Pathways for Purpura

Pathways related to Purpura according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 TNFSF13B TNF THPO MPL ITGB3 ITGA2B
2
Show member pathways
13.3 VWF TNFSF13B TNF ITGB3 ITGA2B IL6
3
Show member pathways
12.85 VWF THPO THBD SERPINC1 PROS1 PROC
4
Show member pathways
12.74 THBD SERPINC1 PROS1 PROC F3 F2
5
Show member pathways
12.62 TNFSF13B TNF THPO IL6 CD40LG
6 12.47 TNFSF13B TNF MPL CD79A CD40LG
7
Show member pathways
12.25 TNF IL6 F2 CRP
8
Show member pathways
12.17 TNF ITGB3 ITGA2B IL6
9
Show member pathways
12.13 THBD PROS1 PROC ITGB3 F2
10
Show member pathways
12.06 VWF ITGB3 ITGA2B GP1BA
11 12.03 VWF THBD SERPINC1 PROS1 PROC F3
12 11.99 TNF THBD ITGB3 ITGA2B
13
Show member pathways
11.96 VWF THBD SERPINC1 PROS1 PROC GP1BA
14 11.9 VWF ITGB3 ITGA2B GP1BA F2
15 11.84 TNF THPO ITGB3 ITGA2B IL6 GP1BA
16 11.83 TNF THBD IL6 F3
17
Show member pathways
11.79 VWF THPO MPL ITGB3 ITGA2B GP1BA
18
Show member pathways
11.74 TNFSF13B TNF CD40LG
19 11.67 TNF THBD IL6
20
Show member pathways
11.66 TNFSF13B TNF CD40LG
21
Show member pathways
11.59 TNF IL6 CD40LG
22 11.47 TNF IL6 CD40LG
23 11.44 ITGB3 ITGA2B IL6
24 11.44 VWF ITGB3 ITGA2B F2
25 11.43 TNF IL6 GP1BA
26 11.29 TNF THPO MPL ITGB3 ITGA2B IL6
27 10.97 TNF IL6 CRP
28 10.9 TNFSF13B TNF THPO ITGB3 ITGA2B IL6
29 10.85 PROS1 PROC F2
30 10.64 VWF GP1BA

GO Terms for Purpura

Cellular components related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.25 TNFSF13B TNF THBD SERPINC1 PROS1 MPL
2 extracellular region GO:0005576 10 VWF TNFSF13B TNF THPO SERPINC1 PROS1
3 collagen-containing extracellular matrix GO:0062023 9.8 VWF SERPINC1 F3 F2 APOH
4 external side of plasma membrane GO:0009897 9.73 TNF THBD ITGA2B F2 CD79A CD40LG
5 endoplasmic reticulum lumen GO:0005788 9.72 SERPINC1 PROC IL6 F2 ADAMTS13
6 blood microparticle GO:0072562 9.67 SERPINC1 PROS1 ITGA2B F2
7 cell surface GO:0009986 9.65 TNF THBD MPL ITGB3 ITGA2B GP1BA
8 extracellular space GO:0005615 9.5 TNFSF13B TNF THPO THBD SERPINC1 PROS1

Biological processes related to Purpura according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.93 VWF TNF ITGB3 ITGA2B ADAMTS13
2 cellular protein metabolic process GO:0044267 9.91 SERPINC1 PROC IL6 F2
3 positive regulation of protein phosphorylation GO:0001934 9.89 TNF THPO ITGB3 F2
4 leukocyte migration GO:0050900 9.89 TNF THBD PROS1 ITGB3 F2
5 integrin-mediated signaling pathway GO:0007229 9.83 ITGB3 ITGA2B CD40LG ADAMTS13
6 platelet degranulation GO:0002576 9.83 VWF PROS1 ITGB3 ITGA2B APOH
7 positive regulation of T cell proliferation GO:0042102 9.77 TNFSF13B IL6 CD40LG
8 platelet aggregation GO:0070527 9.76 MPL ITGB3 ITGA2B GP1BA
9 acute-phase response GO:0006953 9.73 IL6 F2 CRP
10 positive regulation of JAK-STAT cascade GO:0046427 9.72 TNF IL6 F2
11 blood coagulation, intrinsic pathway GO:0007597 9.71 VWF GP1BA F2 APOH
12 platelet activation GO:0030168 9.7 VWF ITGB3 IL6 GP1BA F2 CD40LG
13 fibrinolysis GO:0042730 9.69 PROS1 GP1BA F2
14 negative regulation of blood coagulation GO:0030195 9.67 THBD PROS1 PROC APOH
15 negative regulation of fibrinolysis GO:0051918 9.65 THBD F2 APOH
16 blood coagulation GO:0007596 9.65 VWF THBD SERPINC1 PROS1 PROC ITGB3
17 regulation of blood coagulation GO:0030193 9.62 SERPINC1 GP1BA F2 APOH
18 negative regulation of platelet activation GO:0010544 9.61 THBD F2
19 regulation of immunoglobulin secretion GO:0051023 9.58 TNF CD40LG
20 thrombopoietin-mediated signaling pathway GO:0038163 9.58 THPO MPL
21 immunoglobulin secretion GO:0048305 9.57 TNFSF13B CD40LG
22 negative regulation of lipid storage GO:0010888 9.56 TNF ITGB3 IL6 CRP
23 hemostasis GO:0007599 9.28 VWF THBD SERPINC1 PROS1 PROC GP1BA

Molecular functions related to Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 VWF TNFSF13B TNF THBD SERPINC1 PROC
2 calcium ion binding GO:0005509 9.88 THBD PROS1 PROC F2 CRP ADAMTS13
3 identical protein binding GO:0042802 9.86 VWF TNF SERPINC1 ITGB3 ITGA2B CRP
4 integrin binding GO:0005178 9.62 VWF ITGB3 CD40LG ADAMTS13
5 fibrinogen binding GO:0070051 9.37 ITGB3 ITGA2B
6 cytokine activity GO:0005125 9.35 TNFSF13B TNF THPO IL6 CD40LG
7 tumor necrosis factor receptor binding GO:0005164 9.33 TNFSF13B TNF CD40LG
8 protease binding GO:0002020 9.02 VWF TNF SERPINC1 ITGB3 F3

Sources for Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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