Purpura Fulminans disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A purpura characterized by blood spots, bruising and discoloration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leading to skin necrosis and disseminated intravascular coagulation. It is often fatal.

MalaCards based summary: Purpura Fulminans, also known as purpura gangrenosa, is related to protein c deficiency and protein s deficiency. An important gene associated with Purpura Fulminans is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways/superpathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Wikipedia: ⁷⁵ Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising... more...

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Related Diseases for Purpura Fulminans

Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)

#	Related Disease	Score	Top Affiliating Genes
1	protein c deficiency	31.6	THBD SERPINC1 PROCR PROC F5 F2
2	protein s deficiency	31.2	THBD SERPINC1 PROS1 PROC F5 F3
3	purpura	31.2	THBD SERPINC1 PROC F3 F2 ADAMTS13
4	thrombocytopenic purpura, autoimmune	30.7	F3 F2 ADAMTS13
5	meningococcemia	30.7	THBD SERPINC1 PROCR F5
6	waterhouse-friderichsen syndrome	30.5	SERPINC1 F3 F2
7	necrotizing fasciitis	30.3	PLG F3 F2
8	pleural empyema	30.3	PLG F2
9	vitamin k deficiency bleeding	30.3	SERPINC1 PROS1 F3 F2
10	compartment syndrome	30.1	SERPINC1 PLG F3 F2
11	limb ischemia	30.0	SERPINC1 PLG F3
12	adult respiratory distress syndrome	30.0	THBD PLG F5
13	anuria	29.9	F3 F2 ADAMTS13
14	leech infestation	29.8	PLG F3 F2 ADAM10
15	aspiration pneumonia	29.8	F3 F2
16	thrombotic thrombocytopenic purpura	29.8	THBD SERPINC1 F3 ADAMTS13
17	hereditary angioedema	29.8	SERPINC1 PLG F2
18	osteonecrosis	29.8	SERPINC1 PLG F2
19	thrombophilia due to thrombin defect	29.6	THBD SERPINC1 PROCR PROC F5 F3
20	deficiency anemia	29.6	SERPINC1 PLG F3 F2 ADAMTS13
21	lemierre's syndrome	29.5	SERPINC1 PLG F3 F2
22	mitral valve stenosis	29.5	SERPINC1 PLG F3 F2
23	varicose veins	29.5	THBD SERPINC1 F5 F2
24	vascular disease	29.5	THBD SERPINC1 F5 F3 F2
25	factor vii deficiency	29.4	TFPI SERPINC1 F3 F2
26	thrombophilia due to activated protein c resistance	29.3	THBD SERPINC1 PLG F5 F3 F2
27	intracranial thrombosis	29.2	SERPINC1 PLG F5 F3 F2
28	antithrombin iii deficiency	29.2	SERPINC1 PLG F5 F3 F2
29	liver cirrhosis	29.2	SERPINF2 SERPINC1 SERPINA1 F3 F2 ADAMTS13
30	respiratory failure	29.1	THBD SERPINC1 SERPINA1 PLG F3 F2
31	disseminated intravascular coagulation	29.0	THBD TFPI SERPINF2 SERPINC1 PROCR PLG
32	afibrinogenemia, congenital	29.0	SERPINF2 SERPINC1 PLG F5 F3 F2
33	systemic lupus erythematosus	28.9	THBD SERPINC1 PROCR PLG F3 F2
34	thrombophlebitis	28.9	SERPINF2 SERPINC1 PROS1 PROC PLG F5
35	lipoprotein quantitative trait locus	28.9	THBD SERPINC1 SERPINA1 PLG F3 F2
36	pulmonary embolism	28.8	THBD SERPINF2 SERPINC1 PROS1 PROC F5
37	factor viii deficiency	28.8	TFPI SERPINC1 SERPINA1 F5 F3 F2
38	malaria	28.7	THBD SERPINC1 SERPINA1 PROCR PLG F3
39	thrombocytopenia	28.6	THBD SERPINC1 PROS1 PROC F5 F3
40	antiphospholipid syndrome	28.6	THBD TFPI SERPINC1 PROCR F5 F3
41	thrombophilia	28.2	THBD TFPI SERPINF2 SERPINC1 PROS1 PROCR
42	thrombosis	27.3	THBD TFPI SERPINF2 SERPINC1 PROS1 PROCR
43	acquired purpura fulminans	11.6
44	thrombophilia due to protein c deficiency, autosomal recessive	11.4
45	thrombophilia due to protein s deficiency, autosomal recessive	11.4
46	toxic shock syndrome	10.8
47	chickenpox	10.8
48	meningococcal infection	10.7
49	exanthem	10.6
50	bacteremia 2	10.5

Graphical network of the top 20 diseases related to Purpura Fulminans:

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Symptoms & Phenotypes for Purpura Fulminans

GenomeRNAi Phenotypes related to Purpura Fulminans according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with vaccinia virus (VACV) infection	GR00362-A	8.32	SERPINF2

MGI Mouse Phenotypes related to Purpura Fulminans:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	ADAM10 ADAMTS13 F2 F3 F5 PLG
2	nervous system	MP:0003631	10.2	ADAM10 F2 F3 F5 PLG PROC
3	growth/size/body region	MP:0005378	10.1	ADAM10 F2 F3 F5 PLG PROC
4	normal	MP:0002873	10.08	ADAM10 ADAMTS13 F2 F3 PROCR PROS1
5	cardiovascular system	MP:0005385	10.06	ADAM10 F2 F3 F5 PLG PROC
6	embryo	MP:0005380	9.97	ADAM10 F2 F3 F5 PROCR PROS1
7	immune system	MP:0005387	9.96	ADAM10 ADAMTS13 F2 F3 PLG PROC
8	hematopoietic system	MP:0005397	9.85	ADAM10 ADAMTS13 F2 F3 PLG PROC
9	mortality/aging	MP:0010768	9.77	ADAM10 ADAMTS13 F2 F3 F5 PLG
10	integument	MP:0010771	9.23	ADAM10 F2 F3 F5 PLG PROS1

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Drugs & Therapeutics for Purpura Fulminans

Drugs for Purpura Fulminans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Immunoglobulins
2	Antibodies
3	Protein S

Interventional clinical trials:

#	Name	Status	NCT ID
1	Short and Long-term Outcomes of Purpura Fulminans in Adults	Completed	NCT03216577
2	Idiopathic Purpura Fulminans Associated With Anti-PS Antibodies in Children: a French Multicenter Retrospective Study	Completed	NCT04845113
3	Sepsis-Associated Purpura Fulminans International Registry - Europe	Completed	NCT02238795
4	Long-term Sequelae of Childhood Meningitis and Meningococcal Purpura Fulminans in Ile de France: a Multidisciplinary Approach	Recruiting	NCT04685850

Search NIH Clinical Center for Purpura Fulminans

Cochrane evidence based reviews: purpura fulminans

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Genetic Tests for Purpura Fulminans

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Anatomical Context for Purpura Fulminans

Organs/tissues related to Purpura Fulminans:

MalaCards : Skin, Liver, Endothelial, Uterus, Bone Marrow, Testes, Kidney

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Publications for Purpura Fulminans

Articles related to Purpura Fulminans:

(show top 50) (show all 1023)

#	Title	Authors	PMID	Year
1	Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy. ⁵³ ⁶²	Ishimura M...Hara T	18751723	2009
2	Pneumococcal purpura fulminans successfully treated with activated protein C. ⁵³ ⁶²	Minhas KM...Parker J	18791506	2008
3	Modern concepts of the diagnosis and treatment of purpura fulminans. ⁵³ ⁶²	Edlich RF...Long WB	18652566	2008
4	Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. ⁵³ ⁶²	Celikel S...Kalyoncu AF	17068406	2007
5	Treatment of acute infectious purpura fulminans with activated protein C. ⁵³ ⁶²	Lokeshwar MR...Kapadia FN	16820663	2006
6	[Sepsis-associated coagulation disorders]. ⁵³ ⁶²	Dempfle CE	15924156	2005
7	Purpura fulminans due to Staphylococcus aureus. ⁵³ ⁶²	Kravitz GR...Schlievert PM	15824983	2005
8	Homozygous type I Protein C deficiency in neonatal purpura fulminans with a novel frame-shift deletion of 10 base pairs in exon 8 of PROC gene. ⁵³ ⁶²	Park HJ...Kim MJ	15748260	2005
9	Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. ⁵³ ⁶²	Edlich RF...Long WB	15715517	2005
10	[Recombinant human activated protein C in the treatment of children with meningococcal purpura fulminans]. ⁵³ ⁶²	Martinon-Torres F...Martinon Sanchez JM	15469811	2004
11	Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass. ⁵³ ⁶²	Cone LA...Sofonio MV	15186640	2004
12	Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis. ⁵³ ⁶²	Texereau J...Mira JP	15118537	2004
13	Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. ⁵³ ⁶²	Manco-Johnson MJ...Knapp-Clevenger R	14707707	2004
14	Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetic study. ⁵³ ⁶²	Fourrier F...Noizet O	12761614	2003
15	Purpura fulminans in a child with combined heterozygous prothrombin G20210A and factor V Leiden mutations. ⁵³ ⁶²	Ozbek N...Kayiran SM	12601492	2003
16	Severe protein S deficiency associated with heterozygous factor V Leiden mutation in a child with purpura fulminans. ⁵³ ⁶²	Dogan Y...Gurgey A	12687747	2003
17	[Physiopathology and curative treatment of meningococcal diseases: current aspects]. ⁵³ ⁶²	Senneville E...Baclet V	12504371	2002
18	Plasma exchange as a source of protein C for acute onset protein C pathway failure. ⁵³ ⁶²	Hodgson A...Smith OP	11886399	2002
19	An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. ⁵³ ⁶²	White B...Smith OP	11090052	2000
20	Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation. ⁵³ ⁶²	Patel GK...Anstey AV	11122039	2000
21	A case of purpura fulminans is caused by homozygous delta8857 mutation (protein C-nagoya) and successfully treated with activated protein C concentrate. ⁵³ ⁶²	Nakayama T...Saito H	10997987	2000
22	Postinfection purpura fulminans in a patient heterozygous for prothrombin G20210A and acquired protein S resistance. ⁵³ ⁶²	al-Ismail S...O'Hagan M	10599098	1999
23	Effect of the Factor V Leiden mutation on the severity of meningococcal disease. ⁵³ ⁶²	Kondaveeti S...Levin M	10530586	1999
24	Adult purpura fulminans and digital necrosis associated with sepsis and the factor V mutation. ⁵³ ⁶²	Jackson RT...Luplow RE	9846775	1998
25	Varicella purpura fulminans associated with heterozygosity for factor V leiden and transient protein S deficiency. ⁵³ ⁶²	Woods CR...Johnson CA	9794956	1998
26	Homozygous Factor V Leiden mutation in a child with meningococcal purpura fulminans. ⁵³ ⁶²	Sackesen C...Parlak H	9469407	1998
27	[Purpura fulminans in the newborn. Report of two cases successfully treated with heparin and antithrombin III]. ⁵³ ⁶²	Ficuccilli F...Colarizi P	9577159	1997
28	Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. ⁵³ ⁶²	Inbal A...Seligsohn U	9241737	1997
29	Neonatal purpura fulminans in association with factor V R506Q mutation. ⁵³ ⁶²	Pipe SW...Castle VP	8627449	1996
30	Meningococcal purpura fulminans treated with antithrombin III concentrate: what is the optimal replacement therapy? ⁵³ ⁶²	Cobcroft R...Scott D	7848164	1994
31	A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy. ⁵³ ⁶²	Millar DS...Cooper DN	7841323	1994
32	Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates. ⁵³ ⁶²	Fourrier F...Mangalaboyi J	2139671	1990
33	Panton-Valentine leucocidin-producing Staphylococcus aureus: a clinical review. ⁶²	Hussain K...Fuller LC	36040400	2022
34	An Atypical Case of Idiopathic Purpura Fulminans. ⁶²	Samman K...Michon B	35700409	2022
35	Two Cases of COVID-19 Patients with Associated Purpura Fulminans. ⁶²	Pangburn J...Gibbs J	36402743	2022
36	Immunoadsorption therapy for a meningococcemia patient with myocarditis, adrenal hemorrhage, and purpura fulminans: a case report. ⁶²	Akcay N...Sevketoglu E	34284056	2022
37	Purpura fulminans due to Rickettsia japonica. ⁶²	Ishii J...Shime N	35976146	2022
38	Purpura fulminans in probable scrub typhus group of rickettsioses from hilly region in Nepal - A case report. ⁶²	Nepal D...Shah B	36268303	2022
39	Multiple free dorsal flaps for symmetrical peripheral gangrene of the extremities: A case report. ⁶²	Ishikawa S...Ichioka S	35591861	2022
40	Purpura fulminans due to Stenotrophomonas maltophilia infection. ⁶²	Gressenberger P...Jud P	35123942	2022
41	Meningococcaemia In Children-An Under Recognized Public Health Problem In Pakistan. ⁶²	Bibi S...Muhammad K	36414594	2022
42	New-onset diabetic ketoacidosis with purpura fulminans in a child with COVID-19-related multisystem inflammatory syndrome. ⁶²	Parappil P...Acharya S	35300573	2022
43	Kawasaki Disease with Peripheral and Facial Gangrene: A Case report and review of literature. ⁶²	Madan D...Sharma S	35345947	2022
44	Clustered Incidence of Leukocytoclastic Vasculitis and Purpura Fulminans: A Case Series of a Rare Dermatological Manifestation of Rickettsial Disease. ⁶²	Pinto CJ...Patel RJ	36039228	2022
45	Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children. ⁶²	Lorton F...Launay E	35696162	2022
46	Purpura fulminans due to Streptococcus pneumoniae bacteraemia in an unsplectomised immunocompetent adult without primary hypocomplementaemia. ⁶²	Perinkulam Sathyanarayanan S...Hericks A	35589268	2022
47	Prevalence and clinical features of secondary skin lesions in septic patients with bloodstream infections. ⁶²	Pulido-Perez A...Bouza E	35320429	2022
48	Routine use of 16S rRNA PCR and subsequent sequencing from blood samples in septic shock: about two case reports of Capnocytophaga canimorsus infection in immunocompetent patients. ⁶²	Martins-Baltar A...Francois B	35397547	2022
49	Purpura fulminans, TEN, and disseminated herpes simplex: An unexpected combination. ⁶²	Holm S...Huss F	35498363	2022
50	Severe acquired purpura fulminans in a child. ⁶²	Liniger S...Kartal-Kaess M	34417189	2022

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Genes for Purpura Fulminans

Genes related to Purpura Fulminans (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	45.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	7841323 9577159 15748260 (more) 15186640
2	PROCR	Protein C Receptor	Protein Coding	23.98	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20077621
3	SERPINC1	Serpin Family C Member 1	Protein Coding	23.89	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9577159 12761614 11090052 (more) 2139671 15186640 18652566 7848164 12504371
4	F2	Coagulation Factor II, Thrombin	Protein Coding	14.8	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	F5	Coagulation Factor V	Protein Coding	14.38	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9241737 14707707 17068406 (more) 8627449 11122039 18791506 16820663 10530586 12687747 9794956 15824983 15469811 10997987 15118537 10599098 15715517 9469407 18751723 15924156 11886399 9846775 12601492
6	F3	Coagulation Factor III, Tissue Factor	Protein Coding	14.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	PROS1	Protein S	Protein Coding	14.15	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
8	SERPINF2	Serpin Family F Member 2	Protein Coding	12.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	SERPINA1	Serpin Family A Member 1	Protein Coding	11.94	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	11.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	THBD	Thrombomodulin	Protein Coding	6.9	DISEASES inferred ¹⁴
12	PLG	Plasminogen	Protein Coding	6.23	DISEASES inferred ¹⁴
13	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	5.98	DISEASES inferred ¹⁴
14	ADAMTS13	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13	Protein Coding	5.75	DISEASES inferred ¹⁴

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Variations for Purpura Fulminans

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Expression for Purpura Fulminans

Search GEO for disease gene expression data for Purpura Fulminans.

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Pathways for Purpura Fulminans

Pathways related to Purpura Fulminans according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.62	SERPINC1 SERPINA1 PROS1 PROC PLG F5
2	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.8	THBD TFPI SERPINF2 SERPINC1 SERPINA1 PROS1
3	Collagen chain trimerization ⁶⁶ Show member pathways Anchoring fibril formation ⁶⁶ Assembly of collagen fibrils and other multimeric structures ⁶⁶ Blood Coagulation Cascade ⁶⁴ Collagen biosynthesis and modifying enzymes ⁶⁶ Collagen degradation ⁶⁶ Collagen formation ⁶⁶ Crosslinking of collagen fibrils ⁶⁶ Intrinsic Prothrombin Activation Pathway ⁶⁴	12.51	THBD TFPI SERPINC1 PROS1 PROC F5
4	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.17	ADAM10 F2 F5 PLG PROC SERPINA1
5	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	11.96	THBD PROS1 PROCR PROC F2
6	Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) ⁶⁶ Show member pathways Blood clotting cascade ⁷⁴ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Complement and coagulation cascades ⁷⁴ Defective F8 binding to von Willebrand factor ⁶⁶ Defective F8 cleavage by thrombin ⁶⁶ Defective F8 sulfation at Y1699 ⁶⁶ Defective F9 activation ⁶⁶ Defective F9 secretion ⁶⁶ Defective factor IX causes hemophilia B ⁶⁶ Defective factor VIII causes hemophilia A ⁶⁶ Defective factor XII causes hereditary angioedema ⁶⁶ Defective gamma-carboxylation of F9 ⁶⁶ Diseases of hemostasis ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶ Thrombin/protease-activated receptor (PAR) pathway ⁶¹	11.86	THBD TFPI SERPINF2 SERPINC1 SERPINA1 PROS1
7	Adhesion ³	11.78	PLG F3 ADAM10
8	Gamma carboxylation, hypusine formation and arylsulfatase activation ⁶⁶ Show member pathways diphthamide biosynthesis ⁶¹ Gamma-carboxylation of protein precursors ⁶⁶ Gamma-carboxylation, transport, and amino-terminal cleavage of proteins ⁶⁶ hypusine biosynthesis ⁶¹ Hypusine synthesis from eIF5A-lysine ⁶⁶ Removal of aminoterminal propeptides from gamma-carboxylated proteins ⁶⁶ Synthesis of diphthamide-EEF2 ⁶⁶ The activation of arylsulfatases ⁶⁶ Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus ⁶⁶	11.71	PROS1 PROC F2
9	Warfarin Pathway, Pharmacodynamics ⁶⁰ Show member pathways Vitamin K metabolism and activation of dependent proteins ⁷⁴ vitamin K-epoxide cycle ⁶¹	11.1	PROS1 PROC F2
10	Syndecan-4-mediated signaling events ⁶¹	11.04	TFPI PLG F2
11	A-beta Plaque Formation and APP Metabolism ⁶⁵	10.89	PLG ADAM10
12	Dissolution of Fibrin Clot ⁶⁶	10.59	SERPINF2 PLG
13	COVID-19, thrombosis and anticoagulation ⁷⁴	10.3	PLG F2

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GO Terms for Purpura Fulminans

Cellular components related to Purpura Fulminans according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.3	ADAMTS13 F2 F3 F5 PLG PROC
2	cell surface	GO:0009986	10.22	THBD TFPI SERPINF2 PROCR PLG F3
3	collagen-containing extracellular matrix	GO:0062023	10.21	SERPINF2 SERPINC1 SERPINA1 PLG F3 F2
4	blood microparticle	GO:0072562	10.07	F2 PLG PROS1 SERPINC1 SERPINF2
5	endoplasmic reticulum lumen	GO:0005788	10	SERPINC1 SERPINA1 PROC F5 F2 ADAMTS13
6	serine-type endopeptidase complex	GO:1905370	9.88	THBD PROC F2
7	extracellular space	GO:0005615	9.74	THBD TFPI SERPINF2 SERPINC1 SERPINA1 PROS1
8	platelet alpha granule lumen	GO:0031093	9.65	F5 PLG PROS1 SERPINA1 SERPINF2

Biological processes related to Purpura Fulminans according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	10.2	ADAM10 ADAMTS13 F2 PLG PROC THBD
2	negative regulation of endopeptidase activity	GO:0010951	10.1	TFPI SERPINF2 SERPINC1 SERPINA1 PROS1
3	blood coagulation	GO:0007596	10.02	ADAMTS13 F2 F3 F5 PLG PROC
4	protein processing	GO:0016485	10.01	F3 ADAMTS13 ADAM10
5	acute-phase response	GO:0006953	9.95	SERPINF2 SERPINA1 F2
6	fibrinolysis	GO:0042730	9.92	F2 PLG PROS1 SERPINF2
7	negative regulation of platelet activation	GO:0010544	9.81	THBD F2
8	negative regulation of coagulation	GO:0050819	9.8	PROCR PROC
9	negative regulation of blood coagulation	GO:0030195	9.8	THBD TFPI PROS1 PROC
10	negative regulation of fibrinolysis	GO:0051918	9.76	THBD SERPINF2 PLG F2
11	negative regulation of peptidase activity	GO:0010466	9.73	TFPI SERPINF2 SERPINC1 SERPINA1
12	regulation of blood coagulation	GO:0030193	9.7	SERPINC1 F2
13	regulation of body fluid levels	GO:0050878	9.54	PROC F5 F2
14	hemostasis	GO:0007599	9.4	ADAMTS13 F2 F3 F5 PLG PROC

Molecular functions related to Purpura Fulminans according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	10.01	PROC PLG F3 F2
2	protease binding	GO:0002020	9.86	F3 SERPINA1 SERPINC1 SERPINF2
3	endopeptidase inhibitor activity	GO:0004866	9.85	TFPI SERPINF2 PROS1
4	serine-type endopeptidase inhibitor activity	GO:0004867	9.76	TFPI SERPINF2 SERPINC1 SERPINA1
5	peptidase activity	GO:0008233	9.72	PROC PLG F2 ADAMTS13 ADAM10
6	endopeptidase activity	GO:0004175	9.43	PROC PLG ADAMTS13 ADAM10
7	peptidase inhibitor activity	GO:0030414	8.92	TFPI SERPINF2 SERPINC1 SERPINA1

Sources

Sources for Purpura Fulminans

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PRP034 MIFTS: 43	Purpura Fulminans Categories: Blood diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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