MCID: PRL012
MIFTS: 26

Purulent Acute Otitis Media

Categories: Ear diseases

Aliases & Classifications for Purulent Acute Otitis Media

MalaCards integrated aliases for Purulent Acute Otitis Media:

Name: Purulent Acute Otitis Media 12 15
Acute Suppurative Otitis Media 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10435
ICD9CM 34 382.02
ICD10 32 H66.0
UMLS 71 C0155439 C0271431

Summaries for Purulent Acute Otitis Media

Disease Ontology : 12 A suppurative otitis media with sudden onset and a short course.

MalaCards based summary : Purulent Acute Otitis Media, also known as acute suppurative otitis media, is related to mastoiditis and otitis media. An important gene associated with Purulent Acute Otitis Media is PDZD11 (PDZ Domain Containing 11), and among its related pathways/superpathways are Defensins and C-MYB transcription factor network. The drugs carbamide peroxide and Pazufloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and tonsil.

Related Diseases for Purulent Acute Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Purulent Acute Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 mastoiditis 30.2 PRTN3 MPO
2 otitis media 11.0
3 suppurative otitis media 11.0
4 meningitis 10.4
5 haemophilus influenzae 10.3
6 drug allergy 10.3
7 meningoencephalitis 10.3
8 facial paralysis 10.3
9 chronic purulent otitis media 10.3
10 kearns-sayre syndrome 10.1
11 nasopharyngeal carcinoma 10.1
12 osteomyelitis 10.1
13 petrositis 10.1
14 streptococcal meningitis 10.1
15 leukemia 10.1
16 tolosa-hunt syndrome 10.1
17 exostosis 10.1
18 cellulitis 10.1
19 48,xyyy 10.1
20 tuberculous meningitis 10.1
21 orbital granuloma 9.8 PRTN3 MPO
22 allergic cutaneous vasculitis 9.8 PRTN3 MPO
23 vasculitis 9.8 PRTN3 MPO
24 anca-associated vasculitis 9.8 PRTN3 MPO
25 multiple cranial nerve palsy 9.8 PRTN3 MPO
26 pulmonary hemosiderosis 9.8 PRTN3 MPO
27 anti-basement membrane glomerulonephritis 9.8 PRTN3 MPO
28 glomerulonephritis 9.8 PRTN3 MPO
29 mononeuritis of upper limb and mononeuritis multiplex 9.8 PRTN3 MPO
30 mononeuritis multiplex 9.8 PRTN3 MPO
31 subacute bacterial endocarditis 9.8 PRTN3 MPO
32 aortitis 9.8 PRTN3 MPO
33 chondromalacia 9.8 PRTN3 MPO
34 maxillary sinusitis 9.8 PRTN3 MPO
35 scleral disease 9.8 PRTN3 MPO
36 autoimmune vasculitis 9.8 PRTN3 MPO
37 central nervous system vasculitis 9.8 PRTN3 MPO
38 acute proliferative glomerulonephritis 9.8 PRTN3 MPO
39 mononeuropathy 9.8 PRTN3 MPO
40 autoimmune disease of urogenital tract 9.7 PRTN3 MPO
41 rapidly progressive glomerulonephritis 9.7 PRTN3 MPO
42 hypersensitivity vasculitis 9.7 PRTN3 MPO
43 henoch-schoenlein purpura 9.7 PRTN3 MPO
44 hypersensitivity reaction type iii disease 9.7 PRTN3 MPO
45 goodpasture syndrome 9.7 PRTN3 MPO
46 autoimmune disease of blood 9.7 PRTN3 MPO
47 pericardium disease 9.7 PRTN3 MPO
48 polyarteritis nodosa 9.7 PRTN3 MPO
49 churg-strauss syndrome 9.7 PRTN3 MPO
50 crescentic glomerulonephritis 9.7 PRTN3 MPO

Graphical network of the top 20 diseases related to Purulent Acute Otitis Media:



Diseases related to Purulent Acute Otitis Media

Symptoms & Phenotypes for Purulent Acute Otitis Media

Drugs & Therapeutics for Purulent Acute Otitis Media

Drugs for Purulent Acute Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved Phase 1 124-43-6
2 Pazufloxacin Investigational Phase 1 127045-41-4
3 Anti-Infective Agents Phase 1
4 Fluoroquinolones Phase 1
5 Antitubercular Agents Phase 1
6 Anti-Infective Agents, Local Phase 1
7 Anti-Bacterial Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection

Search NIH Clinical Center for Purulent Acute Otitis Media

Genetic Tests for Purulent Acute Otitis Media

Anatomical Context for Purulent Acute Otitis Media

MalaCards organs/tissues related to Purulent Acute Otitis Media:

40
Bone, Brain, Tonsil, Neutrophil

Publications for Purulent Acute Otitis Media

Articles related to Purulent Acute Otitis Media:

(show top 50) (show all 153)
# Title Authors PMID Year
1
[Paracentez]. 61
32241995 2020
2
Differential Diagnosis of Post Auricular Swelling with Mastoid Bone Involvement. 61
31750180 2019
3
Pattern of tympanic membrane perforation in a tertiary hospital in Nigeria. 61
30074009 2018
4
WITHDRAWN: Grommets (ventilation tubes) for recurrent acute otitis media in children. 61
29624209 2018
5
Pediatric Acute Otitis Media in the Era of Pneumococcal Vaccination. 61
28349737 2017
6
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. 61
28239580 2017
7
[Acute suppurative otitis media caused by pasteurella multocida :a case report]. 61
29871210 2017
8
[The specific features of the clinical course of acute suppurative otitis media of viral and mixed viral-bacterial etiology in the children of the preschool age]. 61
29072655 2017
9
[The diagnostics and treatment of otogenic intracranial complications]. 61
27876726 2016
10
Suppurative labyrinthitis associated with otitis media: 26 years' experience. 61
26718959 2016
11
Prevalence of ear diseases in the children of Delhi. 61
25883066 2015
12
[Pulmonary complications in pediatric patients with primary immunodeficiency]. 61
25946525 2015
13
[Cholesteatoma of the external and middle ear in the childhood]. 61
25909669 2015
14
Petrositis With Bilateral Abducens Nerve Palsies complicated by Acute Otitis Media. 61
24587883 2014
15
Montelukast is as effective as penicillin in treatment of acute otitis media: an experimental rat study. 61
24048018 2013
16
Acute otitis media in infants younger than three months not vaccinated against Streptococcus pneumoniae. 61
23601926 2013
17
Three years audit of the emergency patients in the department of ENT of a rural medical college. 61
23360039 2012
18
[Transmeatal aerodynamical otoendoscopy for otitis media]. 61
23250522 2012
19
Scarlet fever caused by community-associated methicillin-resistant Staphylococcus aureus. 61
21813926 2011
20
[First experience with the use of tympanostomy for the management of acute otitis media in children]. 61
22433702 2011
21
Acute infectious complications in stapes surgery. 61
21866741 2010
22
Interferon-gamma in suppurative otitis media: significance of otorrhoea type and disease outcome. 61
19640314 2009
23
The role of retinol in the etiology and outcome of suppurative otitis media. 61
18704470 2009
24
[The use of sinupret in the combined treatment of acute otitis media in children]. 61
19491798 2009
25
Pattern of tympanic membrane perforation in ibadan: a retrospective study. 61
25161451 2008
26
Grommets (ventilation tubes) for recurrent acute otitis media in children. 61
18843668 2008
27
Alloiococcus otitidis--otitis media pathogen or normal bacterial flora? 61
19024598 2008
28
Acute suppurative otitis media. 61
18572776 2008
29
Acute suppurative otitis media: an unusual cause of orbital apex syndrome. 61
19085305 2008
30
The morphology of central tympanic membrane perforations. 61
18298012 2007
31
[Child acute otitis media]. 61
18092722 2007
32
[Epidemiological survey of pneumococcus serotypes in pediatric patients with acute suppurative otitis media]. 61
17338318 2007
33
Antimicrobial utilization pattern in out patient services of ENT department of tertiary care hospital of Eastern Nepal. 61
16449838 2005
34
Cervicofacial nocardiosis in an immunocompetent child. 61
16279004 2005
35
Meningitis with bilateral acute suppurative otitis media caused by Group A streptococcus. 61
15695870 2005
36
Histologic evaluation of the tissue seal and biologic response around cochlear implant electrodes in the human. 61
15129102 2004
37
Adam Politzer (1835-1920): his medical studies and publications in Hungarian. 61
14724496 2004
38
Streptococcus acidominimus infection in a child causing Gradenigo syndrome. 61
12791460 2003
39
Current status of bacterial resistance in the otolaryngology field: results from the Second Nationwide Survey in Japan. 61
12673407 2003
40
Short-course antimicrobial therapy of respiratory tract infections. 61
14498754 2003
41
Abducens nerve palsy as the sole presenting symptom of petrous apicitis. 61
12437811 2002
42
[Otitis media with effusion: a study of 346 cases in an outpatient clinic]. 61
12235880 2002
43
Diagnosis and treatment of the child with a draining ear. 61
12122378 2002
44
Epidemiology of acute otitis media among Saudi children. 61
11852124 2002
45
Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media. 61
11576009 2001
46
Cefdinir vs. amoxicillin/clavulanic acid in the treatment of suppurative acute otitis media in children. 61
11144399 2000
47
A new pathogenesis of mesotympanic (congenital) cholesteatoma. 61
11081605 2000
48
Short-Course antimicrobial therapy for upper respiratory tract infections. 61
10929916 2000
49
[HSP70 expression of middle ear mucosa in acute suppurative otitis media]. 61
12541495 2000
50
Intratemporal and intracranial complications of acute suppurative otitis media in children: renewed interest. 61
10577787 1999

Variations for Purulent Acute Otitis Media

Expression for Purulent Acute Otitis Media

Search GEO for disease gene expression data for Purulent Acute Otitis Media.

Pathways for Purulent Acute Otitis Media

Pathways related to Purulent Acute Otitis Media according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 PRTN3 PDZD11
2 10.52 PRTN3 MPO

GO Terms for Purulent Acute Otitis Media

Cellular components related to Purulent Acute Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 PRTN3 MPO

Biological processes related to Purulent Acute Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 8.62 PRTN3 PDZD11

Sources for Purulent Acute Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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