MCID: PRL001
MIFTS: 34

Purulent Labyrinthitis

Categories: Ear diseases

Aliases & Classifications for Purulent Labyrinthitis

MalaCards integrated aliases for Purulent Labyrinthitis:

Name: Purulent Labyrinthitis 12 15
Suppurative Labyrinthitis 12 73
Acute Suppurative Labyrinthitis 12
Bacterial Labyrinthitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13534
ICD9CM 35 386.33
SNOMED-CT 68 24817009
UMLS 73 C0155506

Summaries for Purulent Labyrinthitis

Disease Ontology : 12 A labyrinthitis which is a bacterial infectious disease of the inner ear, often causing deafness and loss of vestibular function. This is caused when bacteria spread to the inner ear during the course of severe acute otitis media, purulent meningitis, or an enlarging cholesteatoma.

MalaCards based summary : Purulent Labyrinthitis, also known as suppurative labyrinthitis, is related to meningitis and labyrinthitis. An important gene associated with Purulent Labyrinthitis is EPB41 (Erythrocyte Membrane Protein Band 4.1), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. Affiliated tissues include lung, bone and heart, and related phenotypes are hematopoietic system and immune system

Related Diseases for Purulent Labyrinthitis

Diseases related to Purulent Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.2 CCL2 IL1B
2 labyrinthitis 10.2
3 jejunoileitis 10.0 IL1B NOS3
4 acquired immunodeficiency syndrome 10.0 CCR2 IL1B
5 otitis media 10.0
6 pneumococcal meningitis 10.0
7 pulmonary edema 10.0 IL1B NOS3
8 sleep apnea 10.0 IL1B NOS3
9 glucose metabolism disease 10.0 IL1B NOS3
10 retinitis pigmentosa 73 10.0 CCL2 IL1B
11 erdheim-chester disease 10.0 CCL2 IL1B
12 congenital cytomegalovirus 10.0 CCL2 IL1B
13 stachybotrys chartarum 10.0 CCL2 IL1B
14 extrapulmonary tuberculosis 10.0 CCL2 IL1B
15 dengue shock syndrome 10.0 CCL2 IL1B
16 complex regional pain syndrome 9.9 CCL2 IL1B
17 viral encephalitis 9.9 CCL2 IL1B
18 encephalitis 9.9 CCL2 IL1B
19 extrinsic cardiomyopathy 9.9 CCL2 IL1B
20 autoimmune uveitis 9.9 CCL2 IL1B
21 chikungunya 9.9 CCL2 IL1B
22 pyelonephritis 9.9 CCL2 IL1B
23 leptospirosis 9.9 CCL2 IL1B
24 neuritis 9.9 CCL2 IL1B
25 silicosis 9.9 CCL2 IL1B
26 extrinsic allergic alveolitis 9.9 CCL2 IL1B
27 autoimmune disease of central nervous system 9.9 CCL2 IL1B
28 pneumoconiosis 9.9 CCL2 IL1B
29 chorioamnionitis 9.9 CCL2 IL1B
30 transient cerebral ischemia 9.9 CCL2 IL1B
31 autoimmune disease of the nervous system 9.9 CCL2 IL1B
32 bone inflammation disease 9.9 CCL2 IL1B
33 ischemic heart disease 9.9 CCL2 NOS3
34 cytomegalovirus infection 9.9 CCL2 IL1B
35 diabetic macular edema 9.9 CCL2 NOS3
36 peritonitis 9.9 CCL2 IL1B
37 aortic aneurysm, familial abdominal, 1 9.9 CCL2 IL1B
38 peripheral artery disease 9.9 CCL2 NOS3
39 trypanosomiasis 9.9 CCL2 IL1B
40 proteasome-associated autoinflammatory syndrome 1 9.9 CCL2 IL1B
41 chagas disease 9.9 CCL2 IL1B
42 periodontitis 9.9 CCL2 IL1B
43 respiratory system disease 9.9 CCL2 IL1B
44 demyelinating disease 9.9 CCL2 IL1B
45 endometriosis 9.8 CCL2 IL1B
46 atherosclerosis susceptibility 9.8 CCL2 NOS3
47 interstitial lung disease 9.8 CCL2 IL1B
48 macular degeneration, age-related, 1 9.8 CCL2 CCR2 IL1B
49 sarcoidosis 1 9.8 CCL2 IL1B
50 arteries, anomalies of 9.7 CCL2 IL1B NOS3

Graphical network of the top 20 diseases related to Purulent Labyrinthitis:



Diseases related to Purulent Labyrinthitis

Symptoms & Phenotypes for Purulent Labyrinthitis

MGI Mouse Phenotypes related to Purulent Labyrinthitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CCR2 EPB41 IL1B NOS3 TRIM37
2 immune system MP:0005387 9.43 CCL2 CCR2 EPB41 IL1B NOS3 TRIM37
3 liver/biliary system MP:0005370 8.92 CCR2 EPB41 NOS3 TRIM37

Drugs & Therapeutics for Purulent Labyrinthitis

Search Clinical Trials , NIH Clinical Center for Purulent Labyrinthitis

Genetic Tests for Purulent Labyrinthitis

Anatomical Context for Purulent Labyrinthitis

MalaCards organs/tissues related to Purulent Labyrinthitis:

41
Lung, Bone, Heart

Publications for Purulent Labyrinthitis

Articles related to Purulent Labyrinthitis:

(show all 13)
# Title Authors Year
1
Quantitative Assessment of Cochlear Histopathologic Findings in Patients With Suppurative Labyrinthitis. ( 26987015 )
2016
2
Suppurative labyrinthitis associated with otitis media: 26 years' experience. ( 26718959 )
2016
3
Radiology quiz case 2. Labyrinthitis ossificans secondary to suppurative labyrinthitis. ( 21422319 )
2011
4
Otogenic cerebellar abscess due to purulent labyrinthitis and defect of the superior semicircular canal and its propagation through the endolymphatic sac. ( 17372752 )
2007
5
Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat. ( 11406118 )
2001
6
Comparative perilymph permeability of cephalosporins and its significance in the treatment and prevention of suppurative labyrinthitis. ( 8546425 )
1996
7
Suppurative labyrinthitis caused by anaerobic bacteria. ( 8035121 )
1994
8
The pathology of suppurative labyrinthitis. ( 4963157 )
1967
9
Purulent labyrinthitis in a newborn infant. ( 5920565 )
1966
10
Suppurative labyrinthitis. ( 14911873 )
1952
11
Suppurative labyrinthitis. ( 21023120 )
1946
12
Acute Suppurative Labyrinthitis Operation With Recovery. ( 20476112 )
1937
13
Suppurative Labyrinthitis, complicated with Suppurative Basal Meningitis; Operation, Translabyrinthine Drainage; Death. ( 19976255 )
1912

Variations for Purulent Labyrinthitis

Expression for Purulent Labyrinthitis

Search GEO for disease gene expression data for Purulent Labyrinthitis.

Pathways for Purulent Labyrinthitis

Pathways related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CCL2 CCR2 IL1B NOS3
2
Show member pathways
12.9 CCL2 CCR2 EPB41 IL1B
3
Show member pathways
12.31 CCL2 CCR2 NOS3
4
Show member pathways
12.22 CCL2 IL1B NOS3
5 12.19 CCL2 CCR2 IL1B
6
Show member pathways
11.87 CCL2 CCR2 IL1B
7 11.69 CCL2 IL1B NOS3
8 11.58 CCL2 CCR2 IL1B
9 11.54 CCL2 IL1B
10 11.53 CCL2 NOS3
11 11.43 CCL2 IL1B NOS3
12 11.41 CCL2 IL1B
13 11.21 CCL2 IL1B
14 11.13 CCL2 CCR2 IL1B
15 11.01 CCL2 NOS3
16 10.96 CCL2 CCR2
17 10.83 CCL2 IL1B
18 10.82 CCL2 CCR2 IL1B
19 10.61 CCL2 IL1B
20 10.48 CCL2 CCR2 IL1B

GO Terms for Purulent Labyrinthitis

Biological processes related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.74 CCL2 CCR2 IL1B
2 inflammatory response GO:0006954 9.7 CCL2 CCR2 IL1B
3 cytokine-mediated signaling pathway GO:0019221 9.61 CCL2 CCR2 IL1B
4 cell chemotaxis GO:0060326 9.58 CCL2 CCR2
5 neutrophil chemotaxis GO:0030593 9.58 CCL2 IL1B
6 chemokine-mediated signaling pathway GO:0070098 9.56 CCL2 CCR2
7 cellular response to organic cyclic compound GO:0071407 9.55 CCL2 IL1B
8 humoral immune response GO:0006959 9.54 CCL2 CCR2
9 response to heat GO:0009408 9.51 IL1B NOS3
10 positive regulation of interferon-gamma production GO:0032729 9.49 CCR2 IL1B
11 monocyte chemotaxis GO:0002548 9.48 CCL2 CCR2
12 protein kinase B signaling GO:0043491 9.46 CCL2 IL1B
13 blood vessel remodeling GO:0001974 9.4 CCR2 NOS3
14 homeostasis of number of cells within a tissue GO:0048873 9.37 CCR2 NOS3
15 JAK-STAT cascade GO:0007259 9.32 CCL2 CCR2
16 positive regulation of T cell activation GO:0050870 9.26 CCL2 CCR2
17 regulation of nitric-oxide synthase activity GO:0050999 9.16 IL1B NOS3
18 cellular homeostasis GO:0019725 8.96 CCL2 CCR2
19 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 CCL2 IL1B NOS3

Molecular functions related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR2 chemokine receptor binding GO:0031727 8.62 CCL2 CCR2

Sources for Purulent Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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