MCID: PRL001
MIFTS: 26

Purulent Labyrinthitis

Categories: Ear diseases, Infectious diseases

Aliases & Classifications for Purulent Labyrinthitis

MalaCards integrated aliases for Purulent Labyrinthitis:

Name: Purulent Labyrinthitis 12 15
Suppurative Labyrinthitis 12 70
Acute Suppurative Labyrinthitis 12
Bacterial Labyrinthitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13534
ICD9CM 34 386.33
SNOMED-CT 67 24817009
UMLS 70 C0155506

Summaries for Purulent Labyrinthitis

Disease Ontology : 12 A labyrinthitis which is a bacterial infectious disease of the inner ear, often causing deafness and loss of vestibular function. This is caused when bacteria spread to the inner ear during the course of severe acute otitis media, purulent meningitis, or an enlarging cholesteatoma.

MalaCards based summary : Purulent Labyrinthitis, also known as suppurative labyrinthitis, is related to labyrinthitis and meningitis. An important gene associated with Purulent Labyrinthitis is MIRLET7A1 (MicroRNA Let-7a-1), and among its related pathways/superpathways are Measles and Gap junction trafficking. Related phenotype is integument.

Related Diseases for Purulent Labyrinthitis

Diseases related to Purulent Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 30.4 NF2 GJB6 GJB2
2 meningitis 10.2
3 facial paralysis 10.1
4 nonsyndromic hearing loss and deafness, dfna3 10.1 GJB6 GJB2
5 nonsyndromic hearing loss 10.1 GJB6 GJB2
6 pseudoainhum 10.1 GJB6 GJB2
7 nonsyndromic hearing loss and deafness, dfnb1 10.1 GJB6 GJB2
8 dfnb1 10.1 GJB6 GJB2
9 viral labyrinthitis 10.1 GJB6 GJB2
10 deafness, autosomal dominant 3b 10.1 GJB6 GJB2
11 deafness, autosomal dominant 3a 10.1 GJB6 GJB2
12 knuckle pads 10.1 GJB6 GJB2
13 bart-pumphrey syndrome 10.1 GJB6 GJB2
14 keratoderma, palmoplantar, with deafness 10.1 GJB6 GJB2
15 deafness, autosomal recessive 1b 10.1 GJB6 GJB2
16 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.1 GJB6 GJB2
17 palmoplantar keratoderma and congenital alopecia 1 10.1 GJB6 GJB2
18 vestibular disease 10.1 GJB6 GJB2
19 x-linked nonsyndromic deafness 10.1 GJB6 GJB2
20 deafness, autosomal dominant 9 10.1 GJB6 GJB2
21 clouston syndrome 10.1 GJB6 GJB2
22 hereditary hearing loss and deafness 10.1 GJB6 GJB2
23 oculodentodigital dysplasia 10.1 GJB6 GJB2
24 deafness, autosomal recessive 1a 10.1 GJB6 GJB2
25 vohwinkel syndrome 10.1 GJB6 GJB2
26 deafness, x-linked 2 10.1 GJB6 GJB2
27 deafness, autosomal recessive 12 10.0 GJB6 GJB2
28 erythrokeratodermia variabilis et progressiva 1 10.0 GJB6 GJB2
29 pleural cancer 10.0 NF2 MIRLET7A1
30 auditory system disease 10.0 GJB6 GJB2
31 pleural disease 10.0 NF2 MIRLET7A1
32 branchiootorenal syndrome 10.0 GJB6 GJB2
33 otitis media 10.0
34 mastoiditis 10.0
35 purulent acute otitis media 10.0
36 cholesteatoma of middle ear 10.0
37 suppurative otitis media 10.0
38 bacterial meningitis 10.0
39 perilymphatic fistula 10.0
40 pneumococcal meningitis 10.0
41 pendred syndrome 10.0 GJB6 GJB2
42 inner ear disease 10.0 GJB6 GJB2
43 waardenburg's syndrome 9.9 GJB6 GJB2
44 otosclerosis 9.9 NF2 GJB2
45 middle ear disease 9.9 TLR2 GJB2
46 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8 GJB6 GJB2
47 autosomal dominant nonsyndromic deafness 9.7 GJB6 GJB2
48 congenital cytomegalovirus 9.7 TLR2 GJB6 GJB2
49 keratitis, hereditary 9.7 TLR2 GJB6 GJB2
50 serous labyrinthitis 9.6 TLR2 NF2 GJB2

Graphical network of the top 20 diseases related to Purulent Labyrinthitis:



Diseases related to Purulent Labyrinthitis

Symptoms & Phenotypes for Purulent Labyrinthitis

MGI Mouse Phenotypes related to Purulent Labyrinthitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 ENTPD3 GJB2 GJB6 NF2 TLR2

Drugs & Therapeutics for Purulent Labyrinthitis

Search Clinical Trials , NIH Clinical Center for Purulent Labyrinthitis

Genetic Tests for Purulent Labyrinthitis

Anatomical Context for Purulent Labyrinthitis

Publications for Purulent Labyrinthitis

Articles related to Purulent Labyrinthitis:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Not 'just' a foreign body in the ear canal. 61
31036742 2019
2
Pediatric Acute Otitis Media in the Era of Pneumococcal Vaccination. 61
28349737 2017
3
Deterioration of Vestibular Cells in Labyrinthitis. 61
27881797 2017
4
Pediatric sudden sensorineural hearing loss: Etiology, diagnosis and treatment in 20 children. 61
27497416 2016
5
Quantitative Assessment of Cochlear Histopathologic Findings in Patients With Suppurative Labyrinthitis. 61
26987015 2016
6
Suppurative labyrinthitis associated with otitis media: 26 years' experience. 61
26718959 2016
7
Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice. 61
22382820 2012
8
Early prediction of postmeningitic hearing loss in children using magnetic resonance imaging. 61
21339394 2011
9
Radiology quiz case 2. Labyrinthitis ossificans secondary to suppurative labyrinthitis. 61
21422319 2011
10
Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media. 61
21029462 2010
11
Deafness due to haemorrhagic labyrinthitis and a review of relapses in Streptococcus suis meningitis. 61
20358139 2010
12
Nitrogen and oxygen molecules in meningitis-associated labyrinthitis and hearing impairment. 61
18084715 2008
13
Otogenic cerebellar abscess due to purulent labyrinthitis and defect of the superior semicircular canal and its propagation through the endolymphatic sac. 61
17372752 2007
14
Imaging of postoperative sensorineural complications of stapes surgery: a pictorial essay. 61
17245063 2007
15
Inner ear and facial nerve complications of acute otitis media with focus on bacteriology and virology. 61
16698694 2006
16
Inhibition of post-meningitic cochlear injury with cerebrospinal fluid irrigation. 61
16455367 2006
17
Extracranial complications of chronic suppurative otitis media. 61
16467754 2006
18
Labyrinthitis secondary to experimental otitis media. 61
15991087 2005
19
[Temporal bone histopathology in a patient suspected of inner ear extension of otitis media]. 61
15952341 2005
20
[Clinical analysis of extracranial and intracranial complications of cholesteatoma otitis media]. 61
15906509 2005
21
Long-term outcome of modified radical mastoidectomy. 61
15453936 2004
22
[Extracranial and intracranial complications of otitis media (with analysis of 60 cases)]. 61
12916357 2003
23
Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis. 61
12744466 2003
24
Labyrinthine fistula as a late complication of middle ear surgery using the canal wall down technique. 61
12438841 2002
25
Acute coalescent mastoiditis and acoustic sequelae in an infant with severe congenital neutropenia. 61
11738697 2002
26
Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat. 61
11406118 2001
27
Effects of depletion of complement in the development of labyrinthitis ossificans. 61
10522941 1999
28
[Streptococcus suis meningitis and neurophysiology of the acoustic system. First case report from Austria]. 61
10483574 1999
29
Intratemporal complications of acute otitis media in infants and children. 61
9807067 1998
30
Histopathological features of a cochlear implant and otogenic meningitis in Mondini dysplasia. 61
9559698 1998
31
Transection and occlusion of lateral semicircular canal in guinea pigs. 61
9415605 1997
32
A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. 61
9353013 1997
33
A human temporal bone study of acute bacterial meningogenic labyrinthitis. 61
8817013 1996
34
Comparative perilymph permeability of cephalosporins and its significance in the treatment and prevention of suppurative labyrinthitis. 61
8546425 1996
35
Suppurative labyrinthitis caused by anaerobic bacteria. 61
8035121 1994
36
What is the best method of treatment for labyrinthine fistulae caused by cholesteatoma? 61
1505095 1992
37
[Image analysis of the inner ear with CT and MR imaging: pre-operative assessment for cochlear implant surgery]. 61
1634988 1992
38
The site of the lesion causing hearing loss in bacterial meningitis: a study of experimental streptococcal meningitis in guinea-pigs. 61
1800912 1991
39
Pathology of labyrinthine ossification. 61
1919313 1991
40
[Fulminant purulent labyrinthitis caused by beta-hemolytic streptococcus group A]. 61
2051874 1991
41
[Inner ear damage induced by bacteria (Mycobacterium chelonae)]. 61
2348283 1990
42
Sensorineural hearing loss in experimental purulent otitis media due to Streptococcus pneumoniae. 61
4062650 1985
43
[Chronic suppurative labyrinthitis following an extensive cavitary operation on the ear]. 61
7090137 1982
44
Poststapedectomy dizziness. A histopathologic report. 61
6976759 1982
45
Surgical anatomy and pathology of the round window. 61
7273452 1981
46
Otitis media with perforation of the tympanic membrane: a longitudinal experimental study. 61
7453453 1980
47
[Aspects of labyrinthectomy (author's transl)]. 61
577402 1977
48
Stapedectomy and fatal meningitis. A human temporal bone study. 61
561934 1977
49
Histopathologic and experimental models for sensory and neural deafness. 61
999143 1976
50
[A case of meningitis following purulent labyrinthitis]. 61
5364986 1969

Variations for Purulent Labyrinthitis

Expression for Purulent Labyrinthitis

Search GEO for disease gene expression data for Purulent Labyrinthitis.

Pathways for Purulent Labyrinthitis

Pathways related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.51 TLR2 ENTPD8 ENTPD3
2
Show member pathways
10.95 GJB6 GJB2

GO Terms for Purulent Labyrinthitis

Cellular components related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.16 GJB6 GJB2
2 connexin complex GO:0005922 8.96 GJB6 GJB2
3 cell body GO:0044297 8.8 TLR2 NF2 GJB2

Biological processes related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 TLR2 NF2 GJB6
2 response to lipopolysaccharide GO:0032496 9.54 TLR2 GJB6 GJB2
3 inner ear development GO:0048839 9.46 GJB6 GJB2
4 cell communication GO:0007154 9.43 GJB6 GJB2
5 response to progesterone GO:0032570 9.4 TLR2 GJB2
6 nucleobase-containing small molecule catabolic process GO:0034656 9.32 ENTPD8 ENTPD3
7 nucleoside diphosphate catabolic process GO:0009134 9.26 ENTPD8 ENTPD3
8 gap junction assembly GO:0016264 9.16 GJB6 GJB2
9 cell communication by electrical coupling GO:0010644 8.96 GJB6 GJB2
10 gap junction-mediated intercellular transport GO:1990349 8.62 GJB6 GJB2

Molecular functions related to Purulent Labyrinthitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 9.52 GJB6 GJB2
2 nucleoside-diphosphatase activity GO:0017110 9.51 ENTPD8 ENTPD3
3 uridine-diphosphatase activity GO:0045134 9.49 ENTPD8 ENTPD3
4 nucleoside-triphosphatase activity GO:0017111 9.48 ENTPD8 ENTPD3
5 guanosine-diphosphatase activity GO:0004382 9.46 ENTPD8 ENTPD3
6 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 9.43 GJB6 GJB2
7 dGTP phosphohydrolase activity GO:0102491 9.4 ENTPD8 ENTPD3
8 8-oxo-dGTP phosphohydrolase activity GO:0102490 9.37 ENTPD8 ENTPD3
9 GTP phosphohydrolase activity GO:0102489 9.32 ENTPD8 ENTPD3
10 dTTP phosphohydrolase activity GO:0102488 9.26 ENTPD8 ENTPD3
11 dUTP phosphohydrolase activity GO:0102487 9.16 ENTPD8 ENTPD3
12 dCTP phosphohydrolase activity GO:0102486 8.96 ENTPD8 ENTPD3
13 dATP phosphohydrolase activity GO:0102485 8.62 ENTPD8 ENTPD3

Sources for Purulent Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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