Aliases & Classifications for Pustulosis of Palm and Sole

MalaCards integrated aliases for Pustulosis of Palm and Sole:

Name: Pustulosis of Palm and Sole 12 15
Psoriasis 44 73
Pustular Psoriasis of the Palms and/or Soles 12
Acrodermatitis Continua of Hallopeau 73
Generalized Pustular Psoriasis 73
Pustulosis of Palms and Soles 73
Palmoplantar Pustulosis 12
Acropustulosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4398
ICD10 33 L40.3
MeSH 44 D011565
NCIt 50 C34888
SNOMED-CT 68 238610005 27520001

Summaries for Pustulosis of Palm and Sole

MalaCards based summary : Pustulosis of Palm and Sole, also known as psoriasis, is related to psoriasis and pustulosis palmaris et plantaris, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Pustulosis of Palm and Sole is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Adipocytokine signaling pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Pustulosis of Palm and Sole

Diseases related to Pustulosis of Palm and Sole via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 psoriasis 33.4 IL36RN TNF TNFRSF1B
2 pustulosis palmaris et plantaris 33.2 IL36RN TNF
3 psoriasis 14, pustular 11.4
4 iritis 10.5 MRAP TNFRSF1B
5 tenosynovitis 10.4 MRAP TNFRSF1B
6 orbital plasma cell granuloma 10.4 MRAP TNFRSF1B
7 chronic orbital inflammation 10.4 MRAP TNFRSF1B
8 anterior scleritis 10.4 MRAP TNFRSF1B
9 pustular psoriasis 10.4 IL36RN TNF
10 posterior scleritis 10.4 MRAP TNF
11 marcus gunn phenomenon 10.3 CHAT MRAP
12 skin sarcoidosis 10.3 TNF TNFRSF1B
13 rheumatoid lung disease 10.3 TNF TNFRSF1B
14 chronic gonococcal salpingitis 10.3 TNF TNFRSF1B
15 subcorneal pustular dermatosis 10.3 IL36RN TNFRSF1B
16 peroneal neuropathy 10.3 TNF TNFRSF1B
17 coccidiosis 10.2 MRAP TNF
18 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
19 sweat gland disease 10.2 TNF TNFRSF1B
20 pyoderma 10.2 IL36RN TNF
21 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
22 geographic tongue 10.2 IL36RN TNF
23 chronic salpingitis 10.2 TNF TNFRSF1B
24 exanthem 10.1 TNF TNFRSF1B
25 cogan syndrome 10.1 TNF TNFRSF1B
26 spondyloarthropathy 10.1 MRAP TNF
27 guillain-barre syndrome 10.0 TNF TNFRSF1B
28 impetigo herpetiformis 10.0 IL1RL2 IL36RN
29 primary bacterial infectious disease 10.0 TNF TNFRSF1B
30 folliculitis 9.9
31 eosinophilic pustular folliculitis 9.9
32 psoriatic arthritis 9.9 IL36RN TNF TNFRSF1B
33 scleral disease 9.9 MRAP TNF TNFRSF1B
34 acute salpingitis 9.9 MRAP TNF TNFRSF1B
35 panuveitis 9.9 MRAP TNF TNFRSF1B
36 palindromic rheumatism 9.9 MRAP TNF TNFRSF1B
37 hypersensitivity reaction type iv disease 9.9 MRAP TNF TNFRSF1B
38 spondyloarthropathy 1 9.9 MRAP TNF TNFRSF1B
39 bone inflammation disease 9.9 MRAP TNF TNFRSF1B
40 intestinal disease 9.9 MRAP TNF TNFRSF1B
41 behcet syndrome 9.8 MRAP TNF TNFRSF1B
42 spondylitis 9.8 TNF TNFRSF1B
43 juvenile rheumatoid arthritis 9.7 TNF TNFRSF1B
44 pityriasis rubra pilaris 9.6 IL1RL2 IL36RN TNFRSF1B
45 vascular dementia 9.3 CHAT TNF

Graphical network of the top 20 diseases related to Pustulosis of Palm and Sole:



Diseases related to Pustulosis of Palm and Sole

Symptoms & Phenotypes for Pustulosis of Palm and Sole

UMLS symptoms related to Pustulosis of Palm and Sole:


exanthema, pruritus, psoriasiform rash

GenomeRNAi Phenotypes related to Pustulosis of Palm and Sole according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 CHAT RAB12 TNF TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 CHAT RAB12 TNF TNFRSF1B

Drugs & Therapeutics for Pustulosis of Palm and Sole

Drugs for Pustulosis of Palm and Sole (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Phase 3,Phase 2
2 Immunoglobulins Phase 4,Phase 3,Phase 2
3 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
4
Menthol Approved Phase 3 2216-51-5 16666
5
Infliximab Approved Phase 3 170277-31-3
6
Etanercept Approved, Investigational Phase 3 185243-69-0
7
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
8
Ustekinumab Approved, Investigational Phase 3 815610-63-0
9 tannic acid Approved, Nutraceutical Phase 3
10 Analgesics Phase 3
11 Gastrointestinal Agents Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Dermatologic Agents Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3
15 Immunosuppressive Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antirheumatic Agents Phase 3,Phase 2
19
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
20
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
21 Keratolytic Agents Phase 2
22 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
2 Palmoplantar Pustular Psoriasis Efficacy and Safety wIth Secukinumab Completed NCT02008890 Phase 3 Placebo
3 A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis Completed NCT00353119 Phase 3 Placebo comparator;Etanercept
4 Safety and Efficacy of Infliximab in Palmoplantar Psoriasis Completed NCT00629772 Phase 3 Placebo;Infliximab
5 An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis Active, not recruiting NCT02641730 Phase 3 Guselkumab;Placebo
6 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)
7 A Study of the Efficacy, Safety and Tolerability of CNTO 1959, a Human Anti-IL 23 Monoclonal Antibody in Participants With Palmoplantar Pustulosis Completed NCT01845987 Phase 2 Placebo;CNTO 1959
8 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2 alitretinoin;Placebo
9 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2 Alefacept
10 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
11 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Active, not recruiting NCT03135548 Phase 2 BI 655130 (low dose);Placebo;BI 655130 (high dose)
12 Efficacy Study of TEPSO® Socks in Improving Palmoplantar Pustulosis Terminated NCT01197989 Phase 2
13 Immune Signature of Palmoplantar Pustulosis Completed NCT01780857
14 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustulosis of Palm and Sole

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: psoriasis

Genetic Tests for Pustulosis of Palm and Sole

Anatomical Context for Pustulosis of Palm and Sole

MalaCards organs/tissues related to Pustulosis of Palm and Sole:

41
Skin, Liver, Neutrophil, Bone, Tongue

Publications for Pustulosis of Palm and Sole

Articles related to Pustulosis of Palm and Sole:

(show top 50) (show all 64)
# Title Authors Year
1
Treatment of acrodermatitis continua of Hallopeau with ustekinumab as monotherapy after failure of anti-TNF agents. ( 29659137 )
2018
2
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
3
A case of acrodermatitis continua of Hallopeau (ACH) successfully treated with sulfasalazine. ( 29696745 )
2018
4
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
5
Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report. ( 29422844 )
2017
6
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2017
7
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
8
Dermoscopy in facilitating the recognition of acrodermatitis continua of Hallopeau. ( 28734002 )
2017
9
Highly Resistant Acrodermatitis Continua of Hallopeau and Pustular Psoriasis. ( 29177142 )
2017
10
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
11
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
12
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2016
13
Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau. ( 26955145 )
2016
14
Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. ( 27683154 )
2016
15
Treatment of Acrodermatitis Continua of Hallopeau With Ustekinumab as Monotherapy. ( 26560053 )
2015
16
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. ( 25471551 )
2015
17
Acrodermatitis continua of Hallopeau (ACH): Two cases successfully treated with adalimumab. ( 24215490 )
2014
18
Case of acrodermatitis continua of Hallopeau following psoriasis with atypical clinical presentation. ( 25346303 )
2014
19
Two cases of acrodermatitis continua of hallopeau associated with generalized arthritis. ( 24476617 )
2013
20
Benefit of gluten-free diet in acrodermatitis continua of Hallopeau associated with celiac disease: a case report. ( 23489102 )
2013
21
Acrodermatitis continua of hallopeau evolving into generalised pustular psoriasis. ( 23716843 )
2013
22
Acrodermatitis continua of Hallopeau is a clinical phenotype of DITRA: evidence that it is a variant of pustular psoriasis. ( 23428889 )
2013
23
Efficacy of adalimumab for the treatment of refractory paediatric acrodermatitis continua of hallopeau. ( 23407925 )
2013
24
Acitretin- and tumor necrosis factor inhibitor-resistant acrodermatitis continua of hallopeau responsive to the interleukin 1 receptor antagonist anakinra. ( 22431771 )
2012
25
Acrodermatitis continua of hallopeau successfully treated with adalimumab. ( 22468174 )
2012
26
Adalimumab for a co-existing clinical condition of Crohn's disease and acrodermatitis continua of Hallopeau. ( 22115391 )
2011
27
A recalcitrant acrodermatitis continua of Hallopeau successfully treated with etanercept. ( 21970208 )
2011
28
Significance of Gram's stain smear, potassium hydroxide mount, culture, and microscopic pathology in the diagnosis of acrodermatitis continua of Hallopeau. ( 21980714 )
2011
29
Acrodermatitis continua of Hallopeau: evolution of treatment options. ( 21950286 )
2011
30
Acrodermatitis continua of Hallopeau appearing at specific, high leucocyte counts. ( 20377584 )
2010
31
Successful treatment of a 9-year-old boy affected by acrodermatitis continua of Hallopeau with targeted ultraviolet B narrow-band phototherapy. ( 20070838 )
2010
32
Treatment of acrodermatitis continua of Hallopeau with TNF-blocking agents: case report and review. ( 20110631 )
2010
33
Acrodermatitis continua of Hallopeau responding to efalizumab therapy. ( 19250321 )
2009
34
Treatment of acrodermatitis continua of Hallopeau with adalimumab. ( 18945314 )
2009
35
An infant with acrodermatitis continua of Hallopeau: successful treatment with thalidomide and UVB therapy. ( 19250426 )
2009
36
Excellent and prolonged response to infliximab in a case of recalcitrant acrodermatitis continua of Hallopeau. ( 18785890 )
2009
37
Long-term control with etanercept (Enbrel) of a severe acrodermatitis continua of Hallopeau refractory to infliximab (Remicade). ( 18503258 )
2008
38
Recalcitrant acrodermatitis continua of hallopeau treated with calcitriol and tacrolimus 0.1% topical treatment. ( 18422537 )
2008
39
Lack of efficacy of etanercept in acrodermatitis continua of Hallopeau. ( 17988345 )
2007
40
Chronically painful right thumb with pustules and onycholysis. Diagnosis: acrodermatitis continua of Hallopeau. ( 17501968 )
2007
41
Acrodermatitis continua of Hallopeau due to oral terbinafine. ( 17854368 )
2007
42
Acrodermatitis continua of Hallopeau on toes successfully treated with a two-compound product containing calcipotriol and betamethasone dipropionate. ( 17852633 )
2007
43
Etanercept responsive acrodermatitis continua of Hallopeau: is a pattern developing? ( 17039659 )
2006
44
Etanercept and recalcitrant acrodermatitis continua of Hallopeau. ( 16991229 )
2006
45
Successful treatment of recalcitrant acrodermatitis continua of Hallopeau with adalimumab and acitretin. ( 16086767 )
2005
46
Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. ( 16286746 )
2005
47
The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of hallopeau. ( 15898294 )
2005
48
Acquired syndactyly secondary to acrodermatitis continua of Hallopeau. ( 15888186 )
2005
49
Successful treatment of acrodermatitis continua of Hallopeau by the tumour necrosis factor-alpha inhibitor infliximab (Remicade). ( 14996123 )
2004
50
Acrodermatitis continua of Hallopeau: was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? ( 12705767 )
2003

Variations for Pustulosis of Palm and Sole

Expression for Pustulosis of Palm and Sole

Search GEO for disease gene expression data for Pustulosis of Palm and Sole.

Pathways for Pustulosis of Palm and Sole

GO Terms for Pustulosis of Palm and Sole

Biological processes related to Pustulosis of Palm and Sole according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic signaling pathway GO:0097190 9.43 TNF TNFRSF1B
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.4 TNF TNFRSF1B
3 positive regulation of interleukin-6 production GO:0032755 9.37 IL1RL2 TNF
4 extrinsic apoptotic signaling pathway GO:0097191 9.32 TNF TNFRSF1B
5 negative regulation of interleukin-6 production GO:0032715 9.26 IL36RN TNF
6 inflammatory response GO:0006954 9.26 IL1RL2 IL36RN TNF TNFRSF1B
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.16 TNF TNFRSF1B
8 cytokine-mediated signaling pathway GO:0019221 8.92 IL1RL2 IL36RN TNF TNFRSF1B

Sources for Pustulosis of Palm and Sole

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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