MCID: PST011
MIFTS: 49

Pustulosis of Palm and Sole

Categories: Skin diseases

Aliases & Classifications for Pustulosis of Palm and Sole

MalaCards integrated aliases for Pustulosis of Palm and Sole:

Name: Pustulosis of Palm and Sole 12 15
Psoriasis 44 73
Pustular Psoriasis of the Palms and/or Soles 12
Acrodermatitis Continua of Hallopeau 73
Generalized Pustular Psoriasis 73
Pustulosis of Palms and Soles 73
Palmoplantar Pustulosis 12
Acropustulosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4398
ICD10 33 L40.3
MeSH 44 D011565
NCIt 50 C34888
SNOMED-CT 68 27520001

Summaries for Pustulosis of Palm and Sole

MalaCards based summary : Pustulosis of Palm and Sole, also known as psoriasis, is related to psoriatic arthritis and pustulosis palmaris et plantaris, and has symptoms including pruritus, exanthema and psoriasiform rash. An important gene associated with Pustulosis of Palm and Sole is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are NF-kappaB Signaling and IL-1 Family Signaling Pathways. The drugs Apremilast and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver.

Related Diseases for Pustulosis of Palm and Sole

Diseases related to Pustulosis of Palm and Sole via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 674)
# Related Disease Score Top Affiliating Genes
1 psoriatic arthritis 33.4 IL36RN TNF TNFRSF1B
2 pustulosis palmaris et plantaris 32.9 AP1S3 IL36RN TNF
3 psoriasis 14, pustular 32.5 AP1S3 IL36RN
4 geographic tongue 32.2 IL36RN TNF
5 systemic onset juvenile idiopathic arthritis 31.7 IL1RN TNF
6 bone inflammation disease 30.5 IL1RN MRAP TNF TNFRSF1B
7 pityriasis rubra pilaris 30.5 IL36RN TNFRSF1B
8 psoriasis 30.4 AP1S3 IL36RN TNF TNFRSF1B
9 pustular psoriasis 30.4 AP1S3 IL36RN TNF
10 acrodermatitis 30.2 AP1S3 IL36RN
11 arthritis 30.2 IL1RN TNF TNFRSF1B
12 spondyloarthropathy 1 30.1 MRAP TNF TNFRSF1B
13 pyoderma 30.1 IL36RN TNF
14 spondylitis 30.1 IL1RN TNF TNFRSF1B
15 spondyloarthropathy 30.0 MRAP TNF
16 subcorneal pustular dermatosis 30.0 IL36RN TNFRSF1B
17 autoimmune disease 29.8 IL1RN TNF TNFRSF1B
18 tenosynovitis 29.7 MRAP TNFRSF1B
19 alopecia areata 29.6 IL1RN TNF
20 behcet syndrome 29.6 IL1RN MRAP TNF TNFRSF1B
21 joint disorders 29.6 IL1RN TNF
22 guillain-barre syndrome 29.6 TNF TNFRSF1B
23 osteomyelitis 29.5 IL1RN TNF
24 familial mediterranean fever 29.5 IL1RN TNF
25 iritis 29.5 MRAP TNFRSF1B
26 juvenile rheumatoid arthritis 29.4 IL1RN TNF TNFRSF1B
27 periodic fever, familial, autosomal dominant 29.3 TNF TNFRSF1B
28 melkersson-rosenthal syndrome 29.3 TNF TNFRSF1B
29 aseptic meningitis 29.3 IL1RN TNF
30 adult-onset still's disease 29.2 IL1RN TNF
31 pericarditis 29.2 IL1RN TNF
32 panuveitis 29.2 MRAP TNF TNFRSF1B
33 exanthem 29.1 IL1RN TNF TNFRSF1B
34 psoriasis 15, pustular 12.3
35 psoriasis 6 12.2
36 psoriasis 3 12.1
37 psoriasis 4 12.1
38 psoriasis 5 12.1
39 psoriasis 8 12.1
40 psoriasis 10 12.1
41 psoriasis 12 12.1
42 mental retardation and psoriasis 12.0
43 psoriasis 9 12.0
44 psoriatic juvenile idiopathic arthritis 11.9
45 tranebjaerg svejgaard syndrome 11.7
46 impetigo herpetiformis 11.6
47 parapsoriasis 11.4
48 chronic recurrent multifocal osteomyelitis 11.3
49 subacute cutaneous lupus erythematosus 11.3
50 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.3

Graphical network of the top 20 diseases related to Pustulosis of Palm and Sole:



Diseases related to Pustulosis of Palm and Sole

Symptoms & Phenotypes for Pustulosis of Palm and Sole

UMLS symptoms related to Pustulosis of Palm and Sole:


pruritus, exanthema, psoriasiform rash

Drugs & Therapeutics for Pustulosis of Palm and Sole

Drugs for Pustulosis of Palm and Sole (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2 Analgesics Phase 4,Phase 3
3 Peripheral Nervous System Agents Phase 4,Phase 3
4 Immunosuppressive Agents Phase 4,Phase 3
5 Immunologic Factors Phase 4,Phase 3,Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
7 Anti-Infective Agents Phase 4
8 Anti-Inflammatory Agents Phase 4,Phase 3
9 Analgesics, Non-Narcotic Phase 4,Phase 3
10 Antirheumatic Agents Phase 4,Phase 3,Phase 2
11 Angiogenesis Inhibitors Phase 4
12 Anti-Bacterial Agents Phase 4
13 Angiogenesis Modulating Agents Phase 4
14 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
15 Antibodies Phase 4,Phase 3,Phase 2
16 Immunoglobulins Phase 4,Phase 3,Phase 2
17
Etanercept Approved, Investigational Phase 3 185243-69-0
18 tannic acid Approved Phase 3
19
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
20
Infliximab Approved Phase 3 170277-31-3
21
Ustekinumab Approved, Investigational Phase 3 815610-63-0
22 Gastrointestinal Agents Phase 3
23 Dermatologic Agents Phase 3,Phase 2
24
Alitretinoin Approved, Investigational Phase 2 5300-03-8 449171 444795
25
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
26 Keratolytic Agents Phase 2
27 Pharmaceutical Solutions Phase 2
28 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Apremilast in Palmo-Plantar Psoriasis Completed NCT02400749 Phase 4 Apremilast;Placebo
2 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
3 A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis Completed NCT00353119 Phase 3 Placebo comparator;Etanercept
4 An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis Completed NCT02641730 Phase 3 Guselkumab;Placebo
5 Palmoplantar Pustular Psoriasis Efficacy and Safety With Secukinumab Completed NCT02008890 Phase 3
6 Safety and Efficacy of Infliximab in Palmoplantar Psoriasis Completed NCT00629772 Phase 3 Placebo;Infliximab
7 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)
8 A Study of the Efficacy, Safety and Tolerability of CNTO 1959, a Human Anti-IL 23 Monoclonal Antibody in Participants With Palmoplantar Pustulosis Completed NCT01845987 Phase 2 Placebo;CNTO 1959
9 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Completed NCT03135548 Phase 2 BI 655130 (low dose);Placebo;BI 655130 (high dose)
10 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2 alitretinoin;Placebo
11 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2 Alefacept
12 A Study to Evaluate the Efficacy and Safety of ANB019 in Subjects With Palmoplantar Pustulosis Recruiting NCT03633396 Phase 2 Placebo
13 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
14 Efficacy Study of TEPSO® Socks in Improving Palmoplantar Pustulosis Terminated NCT01197989 Phase 2
15 Immune Signature of Palmoplantar Pustulosis Completed NCT01780857
16 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustulosis of Palm and Sole

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: psoriasis

Genetic Tests for Pustulosis of Palm and Sole

Anatomical Context for Pustulosis of Palm and Sole

MalaCards organs/tissues related to Pustulosis of Palm and Sole:

41
Skin, T Cells, Liver, Bone, Tongue, Thyroid, Neutrophil

Publications for Pustulosis of Palm and Sole

Articles related to Pustulosis of Palm and Sole:

(show top 50) (show all 1007)
# Title Authors Year
1
A Chinese cross-sectional study on depression and anxiety symptoms in patients with psoriasis vulgaris. ( 30293440 )
2019
2
Depression Symptoms Predict Worse Clinical Response to Etanercept Treatment in Psoriasis Patients. ( 30408786 )
2019
3
Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice. ( 30551443 )
2019
4
"Tar smarts" may have a new meaning for atopic dermatitis and psoriasis. ( 30395913 )
2019
5
Biologics and Psoriasis: The Beat Goes On. ( 30466686 )
2019
6
Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China. ( 30266502 )
2019
7
Genomic alterations driving psoriasis pathogenesis. ( 30287254 )
2019
8
Secukinumab-induced paradoxical pustular psoriasis. ( 30129214 )
2019
9
Depictions of acne and psoriasis influence interpersonal aversion. ( 30048157 )
2019
10
Treatment of acrodermatitis continua of Hallopeau with ustekinumab as monotherapy after failure of anti-TNF agents. ( 29659137 )
2018
11
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
12
A case of acrodermatitis continua of Hallopeau (ACH) successfully treated with sulfasalazine. ( 29696745 )
2018
13
Acrodermatitis continua of Hallopeau successfully treated with secukinumab. ( 30246571 )
2018
14
Acrodermatitis Continua of Hallopeau. ( 30285064 )
2018
15
Acrodermatitis continua of Hallopeau with dense infiltration of IgG4 -positive cells in the lesional dermis. ( 30411319 )
2018
16
Reversibility of alexithymia with effective treatment of moderate-to-severe psoriasis: longitudinal data from EPIDEPSO. ( 30269346 )
2018
17
Psychological Distress, Alexithymia and Alcohol Misuse in Patients with Psoriasis: A Cross-Sectional Study. ( 30206746 )
2018
18
Clinico-dermoscopic features of alopecia areata in patients with psoriasis. ( 30112449 )
2018
19
Self-esteem is related to anxiety in psoriasis patients: A case control study. ( 30314578 )
2018
20
Secukinumab in the therapy of psoriasis and psoriatic arthritis: a safe choice in clinical practice. ( 30526155 )
2018
21
Concurrent development of psoriatic arthritis, drug-induced interstitial pneumonia, and increased anti-nuclear antibodies in a patient with psoriasis vulgaris undergoing adalimumab treatment. ( 30530442 )
2018
22
To what extend is nail ultrasound discriminative between psoriasis, psoriatic arthritis and healthy subjects? ( 30535654 )
2018
23
Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. ( 30552173 )
2018
24
2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis. ( 30499246 )
2018
25
2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis. ( 30499259 )
2018
26
Combination Therapy of Apremilast and Biologic Agent as a Safe Option of Psoriatic Arthritis and Psoriasis. ( 30499418 )
2018
27
A Case of Ostraceous Psoriasis with Psoriatic Arthritis in an AIDS Patient. ( 30504983 )
2018
28
Sleep disorders in patients with psoriatic arthritis and psoriasis. ( 30505012 )
2018
29
Analysis of drug utilization and health care resource consumption in patients with psoriasis and psoriatic arthritis before and after treatment with biological therapies. ( 30518996 )
2018
30
Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress. ( 30429845 )
2018
31
Current pharmacological treatment guidelines for psoriasis and psoriatic arthritis. ( 30449211 )
2018
32
Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort. ( 30471759 )
2018
33
Metabolic syndrome and psoriatic arthritis among patients with psoriasis vulgaris: Quality of life and prevalence. ( 30474868 )
2018
34
Early endothelial progenitor cells and vascular stiffness in psoriasis and psoriatic arthritis. ( 30413175 )
2018
35
Tocilizumab-induced psoriasis-like eruption resolved by shortening the dose interval in a patient with rheumatoid arthritis: a case-based review. ( 30357484 )
2018
36
Bridging the Gaps in the Care of Psoriasis and Psoriatic Arthritis: the Role of Combined Clinics. ( 30367311 )
2018
37
The relationship between smoking, psoriasis and psoriatic arthritis. ( 30380949 )
2018
38
Polyarticular evolution and late-onset psoriasis may be associated with cardiovascular disease in psoriatic arthritis. ( 30398011 )
2018
39
Preliminary development of a questionnaire assessing the impact of psoriasis and psoriatic arthritis on patient's perception of sexuality. ( 30334975 )
2018
40
Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis. ( 30343350 )
2018
41
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. ( 30301895 )
2018
42
Association between psoriasis, psoriatic arthritis and gout: a nationwide population-based study. ( 30317664 )
2018
43
Differences in Palmoplantar Pustulosis and Psoriasis Vulgaris in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Biological Therapy. ( 30323005 )
2018
44
Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis. ( 30271786 )
2018
45
Prevalence and incidence of psoriasis and psoriatic arthritis. ( 30242033 )
2018
46
Treatment use and satisfaction among patients with psoriasis and psoriatic arthritis: results from the NORdic PAtient survey of Psoriasis and Psoriatic arthritis (NORPAPP). ( 30242921 )
2018
47
Recalcitrant annular pustular psoriasis associated with psoriatic arthritis successfully treated with secukinumab. ( 30246137 )
2018
48
Three-dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis. ( 30246363 )
2018
49
The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor α in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis. ( 30206447 )
2018
50
Budget impact model of secukinumab for the treatment of moderate-to-severe psoriasis, psoriatic arthritis, and ankylosing spondylitis in Italy: a cross-indication initiative. ( 30214261 )
2018

Variations for Pustulosis of Palm and Sole

Expression for Pustulosis of Palm and Sole

Search GEO for disease gene expression data for Pustulosis of Palm and Sole.

Pathways for Pustulosis of Palm and Sole

GO Terms for Pustulosis of Palm and Sole

Biological processes related to Pustulosis of Palm and Sole according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 IL1RN IL36RN TNF TNFRSF1B
2 inflammatory response GO:0006954 9.67 IL1RN IL36RN TNF TNFRSF1B
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.63 IL1RN IL36RN TNF
4 cytokine-mediated signaling pathway GO:0019221 9.56 IL1RN IL36RN TNF TNFRSF1B
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.55 TNF TNFRSF1B
6 response to glucocorticoid GO:0051384 9.54 IL1RN TNF
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.52 TNF TNFRSF1B
8 extrinsic apoptotic signaling pathway GO:0097191 9.51 TNF TNFRSF1B
9 positive regulation of JNK cascade GO:0046330 9.5 IL1RN IL36RN TNF
10 positive regulation of JUN kinase activity GO:0043507 9.49 IL1RN TNF
11 negative regulation of interleukin-6 production GO:0032715 9.48 IL36RN TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 TNF TNFRSF1B
13 positive regulation of interleukin-6 production GO:0032755 9.33 IL1RN IL36RN TNF
14 chronic inflammatory response to antigenic stimulus GO:0002439 8.96 IL1RN TNF
15 cellular response to lipopolysaccharide GO:0071222 8.92 IL1RN IL36RN TNF TNFRSF1B

Molecular functions related to Pustulosis of Palm and Sole according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IL1RN IL36RN TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1RN IL36RN
3 interleukin-1 receptor antagonist activity GO:0005152 8.62 IL1RN IL36RN

Sources for Pustulosis of Palm and Sole

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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