MCID: PST062
MIFTS: 51

Pustulosis Palmaris Et Plantaris

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pustulosis Palmaris Et Plantaris

MalaCards integrated aliases for Pustulosis Palmaris Et Plantaris:

Name: Pustulosis Palmaris Et Plantaris 53 59 55
Localized Pustular Psoriasis 53 59 73
Palmoplantar Pustulosis 53 59
Ppp 53 59
Lpp 53 59
Generalized Pustular Psoriasis 73
Pustulosis of Palms and Soles 73

Characteristics:

Orphanet epidemiological data:

59
pustulosis palmaris et plantaris
Inheritance: Autosomal dominant,Autosomal recessive;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA163927
ICD10 via Orphanet 34 L40.3
UMLS via Orphanet 74 C0030246
ICD10 33 L40.3

Summaries for Pustulosis Palmaris Et Plantaris

NIH Rare Diseases : 53 Pustulosis palmaris et plantaris (PPP) is a rare and chronic inflammatory condition that primarily affects the palms of the hands and soles of the feet. Signs and symptoms of the condition generally develop during adulthood and include crops of pustules on one or both hands and/or feet that erupt repeatedly over time. Affected individuals may also experience itching (pruritus), pain, or a burning sensation. The classification of PPP is controversial. Some have proposed that PPP is a variant of psoriasis, while others believe it to be a separate disease. Though the area of involvement is often limited, PPP can have a significant effect on quality of life and can interfere with walking or other daily activities. PPP often has a chronic and relapsing course and may be resistant to treatment. Treatment options may include topical steroids, emollients, certain medications called retinoids, and treatment with light (phototherapy).

MalaCards based summary : Pustulosis Palmaris Et Plantaris, also known as localized pustular psoriasis, is related to psoriasis 14, pustular and lichen disease. An important gene associated with Pustulosis Palmaris Et Plantaris is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and tonsil, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 76 Pustulosis palmaris et plantaris (also known as pustulosis of palms and soles,palmoplantar pustulosis,... more...

Related Diseases for Pustulosis Palmaris Et Plantaris

Diseases related to Pustulosis Palmaris Et Plantaris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 32.6 AP1S3 IL36RN
2 lichen disease 31.5 CD40LG CD79A CXCR3 TNF
3 pustulosis of palm and sole 31.2 IL36RN TNF
4 iga glomerulonephritis 30.9 CD40LG CD79A TGFB1
5 hypersensitivity reaction type iii disease 30.6 CD40LG CD79A SELE
6 lichen planus 30.2 CXCR3 ITGAL TNF
7 vasculitis 29.6 CD40LG CD79A ELANE SELE TNF
8 pustular psoriasis 29.3 AP1S3 ELANE IL36RN TNF
9 skin disease 29.0 CD79A IL36RN IL5 SELE TNF
10 dermatitis, atopic 28.3 CCL20 CCR4 CXCR3 IL5 SELE TNF
11 psoriasis 26.9 AP1S3 CCL20 CXCR3 IL36RN ITGAL SELE
12 lichen planopilaris 11.9
13 lichen planus pigmentosus 11.5
14 vacterl association 11.4
15 esophageal atresia 11.4
16 pneumonic plague 11.3
17 esophageal atresia/tracheoesophageal fistula 11.3
18 lichen planus pemphigoides 11.2
19 periodontitis, aggressive, 1 11.2
20 celiac disease 1 11.1
21 lipomatosis, multiple 11.0
22 infiltrating lipoma 10.9
23 pedophilia 10.9
24 prostate carcinoma in situ 10.9
25 enamel erosion 10.9
26 androgenic alopecia 10.9
27 paraphilia disorder 10.9
28 hair disease 10.9
29 acute monoblastic leukemia 10.9
30 acute t cell leukemia 10.9
31 pseudopelade of brocq 10.9
32 selective igg deficiency disease 10.8 CD40LG CD79A
33 c1q nephropathy 10.8 CD40LG CD79A
34 leukemia, acute myeloid 10.8
35 meningovascular neurosyphilis 10.8 CD40LG CD79A
36 alpha chain disease 10.8 CD40LG CD79A
37 brill-zinsser disease 10.8 CD40LG CD79A
38 exudative glomerulonephritis 10.8 CD40LG CD79A
39 cork-handlers' disease 10.8 CD40LG CD79A
40 salpingo-oophoritis 10.8 CD40LG CD79A
41 early yaws 10.8 CD40LG CD79A
42 ventilation pneumonitis 10.8 CD40LG CD79A
43 chronic interstitial cystitis 10.8 CD40LG CD79A
44 axillary adenitis 10.8 CD40LG CD79A
45 cryofibrinogenemia 10.7 CD40LG CD79A
46 trichostrongyloidiasis 10.7 CD40LG CD79A
47 subacute bacterial endocarditis 10.7 CD40LG CD79A
48 immunoglobulin g deficiency 10.7 CD40LG CD79A
49 orbital granuloma 10.7 CD40LG CD79A
50 transient hypogammaglobulinemia of infancy 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Pustulosis Palmaris Et Plantaris:



Diseases related to Pustulosis Palmaris Et Plantaris

Symptoms & Phenotypes for Pustulosis Palmaris Et Plantaris

GenomeRNAi Phenotypes related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 TGFB1 CCL20 CCR6 CD79A IL5 ITGAL

MGI Mouse Phenotypes related to Pustulosis Palmaris Et Plantaris:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CD40LG IL5 CD79A ITGAL CXCR3 ITGB1
2 homeostasis/metabolism MP:0005376 10.24 CD40LG IL5 CD79A ITGAL CXCR3 ITGB1
3 immune system MP:0005387 10.22 CD40LG IL5 CD79A ITGAL CXCR3 ITGB1
4 cellular MP:0005384 10.17 CD40LG CD79A ITGAL CXCR3 ITGB1 TNF
5 cardiovascular system MP:0005385 10.11 IL36RN CD40LG CXCR3 TNF SELE SMAD7
6 integument MP:0010771 9.91 CD40LG ITGB1 IL36RN SELE TNF SELPLG
7 neoplasm MP:0002006 9.76 IL5 CD79A ITGAL CXCR3 ITGB1 ELANE
8 normal MP:0002873 9.61 IL36RN CD79A CXCR3 ITGB1 ELANE CCR6
9 respiratory system MP:0005388 9.17 IL5 CXCR3 ITGB1 CCR4 TNF SELE

Drugs & Therapeutics for Pustulosis Palmaris Et Plantaris

Drugs for Pustulosis Palmaris Et Plantaris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Phase 3,Phase 2
2 Immunoglobulins Phase 4,Phase 3,Phase 2
3 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
4
Menthol Approved Phase 3 2216-51-5 16666
5
Infliximab Approved Phase 3 170277-31-3
6
Etanercept Approved, Investigational Phase 3 185243-69-0
7
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
8
Ustekinumab Approved, Investigational Phase 3 815610-63-0
9 tannic acid Approved, Nutraceutical Phase 3
10 Analgesics Phase 3
11 Gastrointestinal Agents Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Dermatologic Agents Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3
15 Immunosuppressive Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antirheumatic Agents Phase 3,Phase 2
19
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
20
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
21 Keratolytic Agents Phase 2
22 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
2 Palmoplantar Pustular Psoriasis Efficacy and Safety wIth Secukinumab Completed NCT02008890 Phase 3 Placebo
3 A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis Completed NCT00353119 Phase 3 Placebo comparator;Etanercept
4 Safety and Efficacy of Infliximab in Palmoplantar Psoriasis Completed NCT00629772 Phase 3 Placebo;Infliximab
5 An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis Active, not recruiting NCT02641730 Phase 3 Guselkumab;Placebo
6 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)
7 A Study of the Efficacy, Safety and Tolerability of CNTO 1959, a Human Anti-IL 23 Monoclonal Antibody in Participants With Palmoplantar Pustulosis Completed NCT01845987 Phase 2 Placebo;CNTO 1959
8 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2 alitretinoin;Placebo
9 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2 Alefacept
10 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
11 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Active, not recruiting NCT03135548 Phase 2 BI 655130 (low dose);Placebo;BI 655130 (high dose)
12 Efficacy Study of TEPSO® Socks in Improving Palmoplantar Pustulosis Terminated NCT01197989 Phase 2
13 Immune Signature of Palmoplantar Pustulosis Completed NCT01780857
14 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustulosis Palmaris Et Plantaris

Genetic Tests for Pustulosis Palmaris Et Plantaris

Anatomical Context for Pustulosis Palmaris Et Plantaris

MalaCards organs/tissues related to Pustulosis Palmaris Et Plantaris:

41
Neutrophil, Skin, Tonsil, T Cells, Bone

Publications for Pustulosis Palmaris Et Plantaris

Articles related to Pustulosis Palmaris Et Plantaris:

(show top 50) (show all 82)
# Title Authors Year
1
Presence of keratin-specific antibody-forming cells in palatine tonsils of patients with pustulosis palmaris et plantaris (PPP) and its correlation with prognosis after tonsillectomy. ( 24138121 )
2014
2
Pustulosis palmaris et plantaris successfully treated with leukotriene antagonist. ( 25672791 )
2014
3
Pustulosis palmaris et plantaris. ( 23709543 )
2013
4
Cutaneous small vessel vasculitis accompanied by pustulosis palmaris et plantaris. ( 22548039 )
2012
5
Improvement of pustulosis palmaris et plantaris by periodontal infection control in a patient with chronic periodontitis. ( 22582507 )
2012
6
Increased peripheral Th17 in patients with pustulosis palmaris et plantaris. ( 21229362 )
2011
7
Up-regulation of A91 integrin on tonsillar T cells and its induction by in vitro stimulation with I+-streptococci in patients with pustulosis Palmaris et Plantaris. ( 20714794 )
2010
8
Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 19659772 )
2009
9
Pathogenic role of tonsillar lymphocytes in associated with HSP60/65 in Pustulosis palmaris et plantaris. ( 19268507 )
2009
10
Possible involvement of T cell co-stimulation in pustulosis palmaris et plantaris via the induction of inducible co-stimulator in chronic focal infections. ( 18308514 )
2008
11
Regression of pustulosis palmaris et plantaris by periodontal treatment in a subject with severe periodontitis. ( 17184243 )
2006
12
Pustulosis palmaris et plantaris with prominent hyperkeratosis of the soles. ( 17169098 )
2006
13
Localization of IL-8 and complement components in lesional skin of psoriasis vulgaris and pustulosis palmaris et plantaris. ( 16205070 )
2005
14
Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis palmaris et plantaris. ( 15885643 )
2005
15
Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP). ( 15925831 )
2005
16
Effect of tonsillectomy in patients with pustulosis palmaris et plantaris. ( 15513559 )
2004
17
The role of mercury in pustulosis palmaris et plantaris. ( 12762071 )
2003
18
A case of pustulosis palmaris et plantaris that began as generalized pustular eruption. ( 12692382 )
2003
19
Implication of responses to bacterial heat shock proteins, chronic microbial infections, and dental metal allergy in patients with pustulosis palmaris et plantaris. ( 14694830 )
2003
20
Normal proliferative responses of peripheral blood mononuclear cells to streptococcal preparation OK-432 in patients with pustulosis palmaris et plantaris constitute a distinct feature from the reduced responses observed in those with psoriasis vulgaris, pustular psoriasis, and acrodermatitis continua of Hallopeau. ( 11154870 )
2001
21
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins. ( 11154408 )
2000
22
Exacerbation of pustulosis palmaris et plantaris after topical application of metals accompanied by elevated levels of leukotriene B4 in pustules. ( 10827407 )
2000
23
Pustulosis palmaris et plantaris. ( 11204510 )
2000
24
Increased interleukin-6, interferon-gamma and tumour necrosis factor-alpha production by tonsillar mononuclear cells stimulated with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 10380747 )
1999
25
Pustulosis palmaris et plantaris associated with peripheral neuropathy. ( 10331366 )
1999
26
Soluble E-selectin as a marker of disease activity in pustulosis palmaris et plantaris. ( 10598762 )
1999
27
Itraconazole as a new treatment for pustulosis palmaris et plantaris. ( 9606344 )
1998
28
Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia. ( 9885446 )
1998
29
Osteoarticular manifestations of pustulosis palmaris et plantaris and of psoriasis: two distinct entities. ( 8712880 )
1996
30
Role of adhesion molecules in the development of pustular lesions in patients with pustulosis palmaris et plantaris. ( 8740264 )
1996
31
Expression of heat shock protein 72 on peripheral blood mononuclear cells from patients with pustulosis palmaris et plantaris. ( 8740263 )
1996
32
Cytokine production by tonsillar lymphocytes stimulated with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 9082782 )
1996
33
Decreased bone mineral density in patients with pustulosis palmaris et plantaris. ( 8864362 )
1996
34
The relationships of onset and exacerbation of pustulosis palmaris et plantaris to smoking and focal infections. ( 8648000 )
1995
35
Histological features of palatine tonsils in pustulosis palmaris et plantaris: a morphometric study. ( 8025660 )
1994
36
Lymphocytic hypophysitis, pustulosis palmaris et plantaris and eosinophilia. ( 8061391 )
1994
37
IgA nephropathy associated with pustulosis palmaris et plantaris. ( 7882607 )
1994
38
Serum levels of interleukin 6 in patients with pustulosis palmaris et plantaris. ( 8120238 )
1993
39
Familial cases of psoriasis vulgaris and pustulosis palmaris et plantaris. ( 8340537 )
1993
40
Medullasin levels in neutrophils of patients with pustulosis palmaris et plantaris. ( 8315109 )
1993
41
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. ( 1456137 )
1992
42
Complement fragment C4d and Bb levels in inflammatory skin diseases (e.g. SLE, atopic dermatitis, erythroderma and pustulosis palmaris et plantaris) for assessment of complement activation. ( 1831937 )
1991
43
Renal manifestation of pustulosis palmaris et plantaris. ( 1865581 )
1991
44
[Immunohistological study on human palatine tonsils in cases with pustulosis palmaris et plantaris--the quantitative study by image analyzer]. ( 2181093 )
1990
45
Oral cyclosporin A is effective in clearing persistent pustulosis palmaris et plantaris. ( 1967883 )
1990
46
Tonsillectomy-induced changes in anti-keratin antibodies in patients with pustulosis palmaris et plantaris: a clinical correlation. ( 2471497 )
1989
47
Bone and joint lesions associated with pustulosis palmaris et plantaris. A clinical and histological study. ( 3276698 )
1988
48
Immunological studies on the relation between tonsil and pustulosis palmaris et plantaris. ( 2464899 )
1988
49
Pustulosis palmaris et plantaris: its association with chronic recurrent multifocal osteomyelitis. ( 3889079 )
1985
50
Immunohistological studies on tonsils with recurrent tonsillitis and focus-tonsil with pustulosis palmaris et plantaris. ( 6398610 )
1984

Variations for Pustulosis Palmaris Et Plantaris

Expression for Pustulosis Palmaris Et Plantaris

Search GEO for disease gene expression data for Pustulosis Palmaris Et Plantaris.

Pathways for Pustulosis Palmaris Et Plantaris

Pathways related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 AP1S3 CCL20 CCR6 CD40LG CD79A ELANE
2
Show member pathways
13.7 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
3
Show member pathways
13.61 CCL20 CCR4 CCR6 CD40LG CXCR3 IL36RN
4
Show member pathways
13.46 CCL20 IL5 ITGAL ITGB1 ITGB2 TGFB1
5
Show member pathways
13.33 CCL20 CCR4 CCR6 CXCR3 ITGAL ITGB1
6
Show member pathways
13.3 CCL20 CD40LG IL5 ITGB1 ITGB2 TGFB1
7
Show member pathways
13.25 IL5 ITGAL ITGB1 ITGB2 SELE SELPLG
8
Show member pathways
13.14 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
9
Show member pathways
12.88 CD40LG CD79A ITGAL ITGB1 ITGB2 TNF
10
Show member pathways
12.87 ITGAL ITGB1 ITGB2 TGFB1 TNF
11
Show member pathways
12.84 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
12
Show member pathways
12.82 CD40LG IL5 ITGAL ITGB2 TGFB1 TNF
13
Show member pathways
12.7 ELANE ITGAL ITGB1 ITGB2 TGFB1
14
Show member pathways
12.38 CD40LG IL5 TGFB1 TNF
15 12.37 ITGAL ITGB2 TGFB1 TNF
16
Show member pathways
12.1 CD40LG ITGB1 ITGB2 TGFB1 TNF
17 12.01 CD40LG ITGAL ITGB1 ITGB2
18
Show member pathways
11.99 ITGAL ITGB1 ITGB2 SELE SELPLG TGFB1
19 11.9 CCL20 SELE TNF
20
Show member pathways
11.9 CCL20 CCR4 CCR6 CXCR3
21 11.89 CD79A IL5 ITGAL TNF
22 11.87 ITGB1 ITGB2 TGFB1 TNF
23 11.86 SELE TGFB1 TNF
24 11.84 ITGB2 TGFB1 TNF
25 11.79 CD40LG ITGAL ITGB1 ITGB2 SELE SELPLG
26 11.78 ITGAL ITGB1 ITGB2
27 11.77 SMAD7 TGFB1 TNF
28
Show member pathways
11.72 CD40LG IL5 TNF
29 11.71 ITGB1 ITGB2 TNF
30 11.67 CCL20 ITGAL ITGB2 TGFB1 TNF
31 11.66 CCR6 CXCR3 IL5 TNF
32
Show member pathways
11.62 CD40LG SELE TNF
33 11.57 SMAD7 TGFB1 TNF
34 11.55 ITGAL ITGB2 SELPLG
35 11.5 IL5 SMAD7 TGFB1 TNF
36 11.43 ITGAL ITGB1 ITGB2
37
Show member pathways
11.42 ITGAL ITGB1 ITGB2
38 11.35 ELANE ITGB1 SELE
39 11.35 ELANE ITGB2 SELPLG TNF
40 11.27 CXCR3 ITGAL ITGB2
41 11.2 IL5 TGFB1 TNF
42 10.83 TGFB1 TNF
43 10.79 CD40LG ITGAL ITGB2 SELE TGFB1 TNF

GO Terms for Pustulosis Palmaris Et Plantaris

Cellular components related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.61 CCR6 CD40LG CXCR3 ELANE ITGAL ITGB1
2 membrane raft GO:0045121 9.55 CD79A ITGB1 ITGB2 SELE TNF
3 integrin complex GO:0008305 9.5 ITGAL ITGB1 ITGB2
4 integrin alphaL-beta2 complex GO:0034687 9.26 ITGAL ITGB2
5 external side of plasma membrane GO:0009897 9.23 CCR4 CCR6 CD40LG CD79A CXCR3 ITGB1
6 plasma membrane GO:0005886 10.18 CCR4 CCR6 CD40LG CD79A CXCR3 ITGAL
7 extracellular space GO:0005615 10.03 CCL20 CD40LG ELANE IL36RN IL5 SELE
8 integral component of plasma membrane GO:0005887 10.01 CCR4 CCR6 CD40LG CD79A CXCR3 SELE

Biological processes related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CCL20 CCR4 CCR6 CD40LG IL36RN IL5
2 regulation of signaling receptor activity GO:0010469 9.93 CCL20 CD40LG IL36RN IL5 TGFB1 TNF
3 regulation of immune response GO:0050776 9.92 CD40LG ITGAL ITGB1 ITGB2
4 cytokine-mediated signaling pathway GO:0019221 9.91 CCL20 IL36RN IL5 ITGB1 ITGB2 TGFB1
5 extracellular matrix organization GO:0030198 9.88 ITGAL ITGB1 ITGB2 TNF
6 chemotaxis GO:0006935 9.85 CCL20 CCR4 CCR6 CXCR3
7 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 ITGB1 SMAD7 TGFB1
8 cell-matrix adhesion GO:0007160 9.83 ITGAL ITGB1 ITGB2
9 integrin-mediated signaling pathway GO:0007229 9.82 ITGAL ITGB1 ITGB2
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40LG ITGB2 TGFB1 TNF
11 B cell differentiation GO:0030183 9.8 CD40LG CD79A ITGB1
12 phagocytosis GO:0006909 9.77 ELANE ITGAL ITGB2
13 positive regulation of MAP kinase activity GO:0043406 9.76 ELANE TGFB1 TNF
14 calcium-mediated signaling GO:0019722 9.74 CCR6 CXCR3 SELE
15 chemokine-mediated signaling pathway GO:0070098 9.73 CCL20 CCR4 CCR6 CXCR3
16 positive regulation of superoxide anion generation GO:0032930 9.66 ITGB2 TGFB1
17 negative regulation of growth of symbiont in host GO:0044130 9.66 ELANE TNF
18 pathway-restricted SMAD protein phosphorylation GO:0060389 9.65 SMAD7 TGFB1
19 positive regulation of podosome assembly GO:0071803 9.64 IL5 TNF
20 negative regulation of interleukin-17 production GO:0032700 9.63 IL36RN TGFB1
21 germ cell migration GO:0008354 9.63 ITGB1 TGFB1
22 leukocyte tethering or rolling GO:0050901 9.62 ITGB1 SELE SELPLG TNF
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 ELANE TNF
24 T cell migration GO:0072678 9.61 CCL20 CCR6
25 response to laminar fluid shear stress GO:0034616 9.6 SMAD7 TGFB1
26 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
27 leukocyte migration involved in inflammatory response GO:0002523 9.56 CCR6 ELANE ITGB2 SELE
28 leukocyte migration GO:0050900 9.56 ELANE ITGAL ITGB1 ITGB2 SELE SELPLG
29 leukocyte cell-cell adhesion GO:0007159 9.55 CD40LG ITGAL ITGB1 ITGB2 SELE
30 cellular extravasation GO:0045123 9.54 ITGB2 TNF
31 positive regulation of mononuclear cell migration GO:0071677 9.49 TGFB1 TNF
32 thymocyte migration GO:0072679 9.48 CCL20 CCR6
33 inflammatory response GO:0006954 9.36 CCL20 CCR4 CD40LG CXCR3 IL36RN IL5
34 cell adhesion GO:0007155 10 CXCR3 ITGAL ITGB1 ITGB2 SELE SELPLG

Molecular functions related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.61 ELANE ITGB1 TNF
2 cell adhesion molecule binding GO:0050839 9.43 ITGAL ITGB1 ITGB2
3 C-C chemokine receptor activity GO:0016493 9.37 CCR4 CCR6
4 type I transforming growth factor beta receptor binding GO:0034713 9.32 SMAD7 TGFB1
5 ICAM-3 receptor activity GO:0030369 9.16 ITGAL ITGB2
6 chemokine receptor activity GO:0004950 9.13 CCR4 CCR6 CXCR3
7 cytokine activity GO:0005125 9.1 CCL20 CD40LG IL36RN IL5 TGFB1 TNF
8 protein binding GO:0005515 10.31 AP1S3 CCL20 CCR6 CD40LG CD79A ELANE

Sources for Pustulosis Palmaris Et Plantaris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....