MCID: PST062
MIFTS: 52

Pustulosis Palmaris Et Plantaris

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pustulosis Palmaris Et Plantaris

MalaCards integrated aliases for Pustulosis Palmaris Et Plantaris:

Name: Pustulosis Palmaris Et Plantaris 54 60 56
Localized Pustular Psoriasis 54 60 74
Palmoplantar Pustulosis 54 60
Ppp 54 60
Lpp 54 60
Generalized Pustular Psoriasis 74
Pustulosis of Palms and Soles 74

Characteristics:

Orphanet epidemiological data:

60
pustulosis palmaris et plantaris
Inheritance: Autosomal dominant,Autosomal recessive;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

ICD10 34 L40.3
ICD10 via Orphanet 35 L40.3
UMLS via Orphanet 75 C0030246
Orphanet 60 ORPHA163927

Summaries for Pustulosis Palmaris Et Plantaris

NIH Rare Diseases : 54 Pustulosis palmaris et plantarisĀ (PPP) is a rare and chronic inflammatory condition that primarily affects the palms of the hands and soles of the feet. Signs and symptoms of the condition generally develop during adulthood and include crops of pustules on one or both hands and/or feet that erupt repeatedly over time. Affected individuals may also experience itching (pruritus), pain, or a burning sensation. The classification of PPP is controversial. Some have proposed that PPP is a variant of psoriasis, while others believe it to be a separate disease. Though the area of involvement is often limited, PPP can have a significant effect on quality of life and can interfere with walking or other daily activities. PPP often has a chronic and relapsing course and may be resistant to treatment. Treatment options may include topical steroids, emollients, certain medications called retinoids, and treatment with light (phototherapy).

MalaCards based summary : Pustulosis Palmaris Et Plantaris, also known as localized pustular psoriasis, is related to psoriasis 14, pustular and pustulosis of palm and sole. An important gene associated with Pustulosis Palmaris Et Plantaris is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Apremilast and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and tonsil, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 77 Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or... more...

Related Diseases for Pustulosis Palmaris Et Plantaris

Diseases related to Pustulosis Palmaris Et Plantaris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.0 AP1S3 IL36RN
2 pustulosis of palm and sole 31.4 AP1S3 IL36RN TNF
3 iga glomerulonephritis 30.8 CD40LG CD79A TGFB1
4 vasculitis 30.4 CD40LG ELANE SELE TNF
5 lichen planus 30.3 CXCR3 ITGAL TNF
6 pustular psoriasis 30.1 AP1S3 ELANE IL36RN TNF
7 pyoderma 29.9 IL36RN ITGB2 TNF
8 mycosis fungoides 29.7 CCR4 CXCR3 IL5 ITGAL ITGB2
9 rheumatoid arthritis 29.1 CCL20 CD40LG ITGAL ITGB2 SELE TGFB1
10 lichen planopilaris 12.1
11 lichen planus pigmentosus 11.7
12 lipomatosis, multiple 11.5
13 vacterl association 11.5
14 esophageal atresia 11.5
15 pneumonic plague 11.5
16 esophageal atresia/tracheoesophageal fistula 11.4
17 tracheoesophageal fistula 11.4
18 lichen planus pemphigoides 11.4
19 periodontitis, aggressive, 1 11.4
20 celiac disease 1 11.3
21 tetralogy of fallot 11.3
22 psoriasis 1 11.3
23 pseudopelade of brocq 11.1
24 congenital anomalies of kidney and urinary tract 2 11.1
25 leukemia, acute myeloid 11.1
26 androgenic alopecia 11.1
27 paraphilia disorder 11.1
28 pedophilia 11.1
29 enamel erosion 11.1
30 hair disease 11.1
31 acute t cell leukemia 11.1
32 infiltrating lipoma 11.1
33 lichen disease 11.1
34 prostate carcinoma in situ 11.1
35 seborrheic dermatitis 11.1
36 parapsoriasis 11.1
37 acute monoblastic leukemia 11.1
38 psoriasis 10.7
39 psoriasis 7 10.6
40 psoriasis 11 10.6
41 psoriasis 13 10.6
42 periodontitis 10.5
43 c1q nephropathy 10.4 CD40LG CD79A
44 immunoglobulin g deficiency 10.4 CD40LG CD79A
45 cryofibrinogenemia 10.4 CD40LG CD79A
46 heparin-induced thrombocytopenia 10.4 CD40LG CD79A
47 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
48 pompholyx 10.3
49 panniculitis 10.3
50 pancreatitis 10.3

Graphical network of the top 20 diseases related to Pustulosis Palmaris Et Plantaris:



Diseases related to Pustulosis Palmaris Et Plantaris

Symptoms & Phenotypes for Pustulosis Palmaris Et Plantaris

GenomeRNAi Phenotypes related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CCL20 CCR6 CD79A IL5 ITGAL SELE

MGI Mouse Phenotypes related to Pustulosis Palmaris Et Plantaris:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CCR4 CCR6 CD40LG CD79A CXCR3 ELANE
2 homeostasis/metabolism MP:0005376 10.24 CCR6 CD40LG CD79A CXCR3 ELANE IL36RN
3 immune system MP:0005387 10.22 CCR4 CCR6 CD40LG CD79A CXCR3 ELANE
4 cellular MP:0005384 10.17 CD40LG CD79A CXCR3 ITGAL ITGB1 ITGB2
5 cardiovascular system MP:0005385 10.11 CD40LG CXCR3 IL36RN ITGB1 ITGB2 SELE
6 integument MP:0010771 9.91 CD40LG IL36RN ITGB1 ITGB2 SELE SELPLG
7 neoplasm MP:0002006 9.76 CD79A CXCR3 ELANE IL5 ITGAL ITGB1
8 normal MP:0002873 9.61 CCR6 CD79A CXCR3 ELANE IL36RN ITGB1
9 respiratory system MP:0005388 9.17 CCR4 CXCR3 IL5 ITGB1 SELE TGFB1

Drugs & Therapeutics for Pustulosis Palmaris Et Plantaris

Drugs for Pustulosis Palmaris Et Plantaris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2 Immunologic Factors Phase 4,Phase 3,Phase 2
3 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
4 Immunosuppressive Agents Phase 4,Phase 3
5 Antirheumatic Agents Phase 4,Phase 3,Phase 2
6 Anti-Infective Agents Phase 4
7 Angiogenesis Inhibitors Phase 4
8 Anti-Inflammatory Agents Phase 4,Phase 3
9 Analgesics Phase 4,Phase 3
10 Peripheral Nervous System Agents Phase 4,Phase 3
11 Angiogenesis Modulating Agents Phase 4
12 Analgesics, Non-Narcotic Phase 4,Phase 3
13 Anti-Bacterial Agents Phase 4
14 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
15 Immunoglobulins Phase 4,Phase 3,Phase 2
16 Antibodies Phase 4,Phase 3,Phase 2
17
Etanercept Approved, Investigational Phase 3 185243-69-0
18
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
19
tannic acid Approved Phase 3 1401-55-4
20
Infliximab Approved Phase 3 170277-31-3
21
Ustekinumab Approved, Investigational Phase 3 815610-63-0
22 Gastrointestinal Agents Phase 3
23 Dermatologic Agents Phase 3,Phase 2
24
Alitretinoin Approved, Investigational Phase 2 5300-03-8 449171 444795
25 Antineoplastic Agents, Immunological Phase 2
26 Pharmaceutical Solutions Phase 2
27 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Apremilast in Palmo-Plantar Psoriasis Completed NCT02400749 Phase 4 Apremilast;Placebo
2 Raptiva in Palm and Sole Psoriasis Terminated NCT00972543 Phase 4
3 A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis Completed NCT00353119 Phase 3 Placebo comparator;Etanercept
4 An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis Completed NCT02641730 Phase 3 Guselkumab;Placebo
5 Palmoplantar Pustular Psoriasis Efficacy and Safety With Secukinumab Completed NCT02008890 Phase 3
6 Safety and Efficacy of Infliximab in Palmoplantar Psoriasis Completed NCT00629772 Phase 3 Placebo;Infliximab
7 Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis Terminated NCT01091051 Phase 3 Ustekinumab;Placebo (Soduim Chloride)
8 A Study of the Efficacy, Safety and Tolerability of CNTO 1959, a Human Anti-IL 23 Monoclonal Antibody in Participants With Palmoplantar Pustulosis Completed NCT01845987 Phase 2 Placebo;CNTO 1959
9 Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients Completed NCT03135548 Phase 2 BI 655130 (low dose);Placebo;BI 655130 (high dose)
10 Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis Completed NCT01245140 Phase 2 alitretinoin;Placebo
11 Study to Evaluate the Efficacy of Alefacept to Treat Palmar Plantar Pustulosis Completed NCT00301002 Phase 2 Alefacept
12 A Study to Evaluate the Efficacy and Safety of ANB019 in Subjects With Palmoplantar Pustulosis Recruiting NCT03633396 Phase 2 Placebo
13 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
14 Efficacy Study of TEPSO® Socks in Improving Palmoplantar Pustulosis Terminated NCT01197989 Phase 2
15 Immune Signature of Palmoplantar Pustulosis Completed NCT01780857
16 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Pustulosis Palmaris Et Plantaris

Genetic Tests for Pustulosis Palmaris Et Plantaris

Anatomical Context for Pustulosis Palmaris Et Plantaris

MalaCards organs/tissues related to Pustulosis Palmaris Et Plantaris:

42
Neutrophil, Skin, Tonsil, T Cells, Bone, Kidney, Ovary

Publications for Pustulosis Palmaris Et Plantaris

Articles related to Pustulosis Palmaris Et Plantaris:

(show top 50) (show all 86)
# Title Authors Year
1
Presence of keratin-specific antibody-forming cells in palatine tonsils of patients with pustulosis palmaris et plantaris (PPP) and its correlation with prognosis after tonsillectomy. ( 24138121 )
2014
2
Pustulosis palmaris et plantaris successfully treated with leukotriene antagonist. ( 25672791 )
2014
3
Pustulosis palmaris et plantaris. ( 23709543 )
2013
4
Cutaneous small vessel vasculitis accompanied by pustulosis palmaris et plantaris. ( 22548039 )
2012
5
Improvement of pustulosis palmaris et plantaris by periodontal infection control in a patient with chronic periodontitis. ( 22582507 )
2012
6
Increased peripheral Th17 in patients with pustulosis palmaris et plantaris. ( 21229362 )
2011
7
Unusual case of pemphigus vulgaris mimicking localized pustular psoriasis of the hands and feet. ( 21049731 )
2010
8
Up-regulation of ß1 integrin on tonsillar T cells and its induction by in vitro stimulation with Ī±-streptococci in patients with pustulosis Palmaris et Plantaris. ( 20714794 )
2010
9
Pathogenic role of tonsillar lymphocytes in associated with HSP60/65 in Pustulosis palmaris et plantaris. ( 19268507 )
2009
10
Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 19659772 )
2009
11
Possible involvement of T cell co-stimulation in pustulosis palmaris et plantaris via the induction of inducible co-stimulator in chronic focal infections. ( 18308514 )
2008
12
Pustulosis palmaris et plantaris with prominent hyperkeratosis of the soles. ( 17169098 )
2006
13
Regression of pustulosis palmaris et plantaris by periodontal treatment in a subject with severe periodontitis. ( 17184243 )
2006
14
Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis palmaris et plantaris. ( 15885643 )
2005
15
Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP). ( 15925831 )
2005
16
Localization of IL-8 and complement components in lesional skin of psoriasis vulgaris and pustulosis palmaris et plantaris. ( 16205070 )
2005
17
Effect of tonsillectomy in patients with pustulosis palmaris et plantaris. ( 15513559 )
2004
18
Implication of responses to bacterial heat shock proteins, chronic microbial infections, and dental metal allergy in patients with pustulosis palmaris et plantaris. ( 14694830 )
2003
19
A case of pustulosis palmaris et plantaris that began as generalized pustular eruption. ( 12692382 )
2003
20
The role of mercury in pustulosis palmaris et plantaris. ( 12762071 )
2003
21
Normal proliferative responses of peripheral blood mononuclear cells to streptococcal preparation OK-432 in patients with pustulosis palmaris et plantaris constitute a distinct feature from the reduced responses observed in those with psoriasis vulgaris, pustular psoriasis, and acrodermatitis continua of Hallopeau. ( 11154870 )
2001
22
Localized pustular psoriasis with onycholysis representing a Köbner phenomenon. ( 10954214 )
2000
23
Exacerbation of pustulosis palmaris et plantaris after topical application of metals accompanied by elevated levels of leukotriene B4 in pustules. ( 10827407 )
2000
24
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins. ( 11154408 )
2000
25
Pustulosis palmaris et plantaris. ( 11204510 )
2000
26
Pustulosis palmaris et plantaris associated with peripheral neuropathy. ( 10331366 )
1999
27
Increased interleukin-6, interferon-gamma and tumour necrosis factor-alpha production by tonsillar mononuclear cells stimulated with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 10380747 )
1999
28
Soluble E-selectin as a marker of disease activity in pustulosis palmaris et plantaris. ( 10598762 )
1999
29
Itraconazole as a new treatment for pustulosis palmaris et plantaris. ( 9606344 )
1998
30
Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia. ( 9885446 )
1998
31
Osteoarticular manifestations of pustulosis palmaris et plantaris and of psoriasis: two distinct entities. ( 8712880 )
1996
32
Expression of heat shock protein 72 on peripheral blood mononuclear cells from patients with pustulosis palmaris et plantaris. ( 8740263 )
1996
33
Role of adhesion molecules in the development of pustular lesions in patients with pustulosis palmaris et plantaris. ( 8740264 )
1996
34
Decreased bone mineral density in patients with pustulosis palmaris et plantaris. ( 8864362 )
1996
35
Cytokine production by tonsillar lymphocytes stimulated with alpha-streptococci in patients with pustulosis palmaris et plantaris. ( 9082782 )
1996
36
The relationships of onset and exacerbation of pustulosis palmaris et plantaris to smoking and focal infections. ( 8648000 )
1995
37
Lymphocytic hypophysitis, pustulosis palmaris et plantaris and eosinophilia. ( 8061391 )
1994
38
IgA nephropathy associated with pustulosis palmaris et plantaris. ( 7882607 )
1994
39
Histological features of palatine tonsils in pustulosis palmaris et plantaris: a morphometric study. ( 8025660 )
1994
40
Serum levels of interleukin 6 in patients with pustulosis palmaris et plantaris. ( 8120238 )
1993
41
Medullasin levels in neutrophils of patients with pustulosis palmaris et plantaris. ( 8315109 )
1993
42
Familial cases of psoriasis vulgaris and pustulosis palmaris et plantaris. ( 8340537 )
1993
43
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. ( 1456137 )
1992
44
Complement fragment C4d and Bb levels in inflammatory skin diseases (e.g. SLE, atopic dermatitis, erythroderma and pustulosis palmaris et plantaris) for assessment of complement activation. ( 1831937 )
1991
45
Renal manifestation of pustulosis palmaris et plantaris. ( 1865581 )
1991
46
Oral cyclosporin A is effective in clearing persistent pustulosis palmaris et plantaris. ( 1967883 )
1990
47
[Immunohistological study on human palatine tonsils in cases with pustulosis palmaris et plantaris--the quantitative study by image analyzer]. ( 2181093 )
1990
48
Tonsillectomy-induced changes in anti-keratin antibodies in patients with pustulosis palmaris et plantaris: a clinical correlation. ( 2471497 )
1989
49
Immunological studies on the relation between tonsil and pustulosis palmaris et plantaris. ( 2464899 )
1988
50
Bone and joint lesions associated with pustulosis palmaris et plantaris. A clinical and histological study. ( 3276698 )
1988

Variations for Pustulosis Palmaris Et Plantaris

Expression for Pustulosis Palmaris Et Plantaris

Search GEO for disease gene expression data for Pustulosis Palmaris Et Plantaris.

Pathways for Pustulosis Palmaris Et Plantaris

Pathways related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 AP1S3 CCL20 CCR6 CD40LG CD79A ELANE
2
Show member pathways
13.73 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
3
Show member pathways
13.63 CCL20 CCR4 CCR6 CD40LG CXCR3 IL36RN
4
Show member pathways
13.51 CCL20 IL5 ITGAL ITGB1 ITGB2 SMAD7
5
Show member pathways
13.33 CCL20 CCR4 CCR6 CXCR3 ITGAL ITGB1
6
Show member pathways
13.32 CCL20 CD40LG IL5 ITGB1 ITGB2 TGFB1
7
Show member pathways
13.28 IL5 ITGAL ITGB1 ITGB2 SELE SELPLG
8
Show member pathways
13.18 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
9
Show member pathways
12.89 ITGAL ITGB1 ITGB2 TGFB1 TNF
10
Show member pathways
12.88 CD40LG CD79A ITGAL ITGB1 ITGB2 TNF
11
Show member pathways
12.84 CCL20 CCR4 CCR6 CD40LG CXCR3 IL5
12
Show member pathways
12.83 CD40LG IL5 ITGAL ITGB2 TGFB1 TNF
13
Show member pathways
12.71 ELANE ITGAL ITGB1 ITGB2 TGFB1
14 12.53 CD40LG CD79A ITGB2 TNF
15
Show member pathways
12.52 CD40LG IL5 TGFB1 TNF
16 12.32 ITGAL ITGB2 TGFB1 TNF
17
Show member pathways
12.15 CD40LG ITGB1 ITGB2 TGFB1 TNF
18
Show member pathways
12.08 CCL20 CCR4 CCR6 CXCR3 ITGAL ITGB1
19
Show member pathways
12.05 ITGAL ITGB1 ITGB2 SELE SELPLG TGFB1
20 12.03 CD40LG ITGAL ITGB1 ITGB2
21
Show member pathways
11.94 CCL20 CCR4 CCR6 CXCR3
22 11.93 CD79A IL5 ITGAL TNF
23 11.92 CCL20 SELE TNF
24 11.89 ITGB1 ITGB2 TGFB1 TNF
25 11.87 SELE TGFB1 TNF
26 11.85 ITGB2 TGFB1 TNF
27 11.84 SMAD7 TGFB1 TNF
28 11.8 ITGAL ITGB1 ITGB2
29 11.8 CD40LG ITGAL ITGB1 ITGB2 SELE SELPLG
30
Show member pathways
11.74 CD40LG IL5 TNF
31 11.73 ITGB1 ITGB2 TNF
32 11.73 CCL20 ITGAL ITGB2 TGFB1 TNF
33 11.7 ITGAL ITGB1 ITGB2 TGFB1
34 11.7 CCL20 TGFB1 TNF
35 11.7 CCR6 CXCR3 IL5 TNF
36 11.66 ITGAL ITGB2 SELPLG
37
Show member pathways
11.63 CD40LG SELE TNF
38 11.59 SMAD7 TGFB1 TNF
39 11.56 IL5 SMAD7 TGFB1 TNF
40 11.46 ITGAL ITGB2 TGFB1
41 11.44 ITGAL ITGB1 ITGB2
42
Show member pathways
11.44 ITGAL ITGB1 ITGB2
43 11.39 ELANE ITGB2 SELPLG TNF
44 11.37 ITGAL ITGB1 ITGB2 TGFB1
45 11.37 ELANE ITGB1 SELE
46 11.29 CXCR3 ITGAL ITGB2
47 11.2 IL5 TGFB1 TNF
48 11.17 CCL20 CD40LG IL5 TNF
49 10.85 TGFB1 TNF
50 10.79 CD40LG ITGAL ITGB2 SELE TGFB1 TNF

GO Terms for Pustulosis Palmaris Et Plantaris

Cellular components related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.98 CCR4 CCR6 CD40LG CXCR3 SELE SELPLG
2 cell surface GO:0009986 9.61 CCR6 CD40LG CXCR3 ELANE ITGAL ITGB1
3 membrane raft GO:0045121 9.55 CD79A ITGB1 ITGB2 SELE TNF
4 integrin complex GO:0008305 9.5 ITGAL ITGB1 ITGB2
5 integrin alphaL-beta2 complex GO:0034687 9.26 ITGAL ITGB2
6 external side of plasma membrane GO:0009897 9.23 CCR4 CCR6 CD40LG CD79A CXCR3 ITGB1
7 intracellular GO:0005622 9.16 SMAD7
8 plasma membrane GO:0005886 10.18 CCR4 CCR6 CD40LG CD79A CXCR3 ITGAL
9 extracellular space GO:0005615 10.01 CCL20 CD40LG ELANE IL36RN IL5 SELE

Biological processes related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CCL20 CD40LG IL36RN IL5 TGFB1 TNF
2 regulation of immune response GO:0050776 9.91 CD40LG ITGAL ITGB1 ITGB2
3 extracellular matrix organization GO:0030198 9.9 ITGAL ITGB1 ITGB2 TNF
4 chemotaxis GO:0006935 9.88 CCL20 CCR4 CCR6 CXCR3
5 cytokine-mediated signaling pathway GO:0019221 9.87 CCL20 IL36RN IL5 ITGB1 ITGB2 TGFB1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 CD40LG ITGB2 TGFB1 TNF
7 transforming growth factor beta receptor signaling pathway GO:0007179 9.84 ITGB1 SMAD7 TGFB1
8 cell-matrix adhesion GO:0007160 9.83 ITGAL ITGB1 ITGB2
9 integrin-mediated signaling pathway GO:0007229 9.83 ITGAL ITGB1 ITGB2
10 neutrophil chemotaxis GO:0030593 9.81 CCL20 IL36RN ITGB2
11 B cell differentiation GO:0030183 9.8 CD40LG CD79A ITGB1
12 calcium-mediated signaling GO:0019722 9.8 CCR4 CCR6 CXCR3 SELE
13 cell chemotaxis GO:0060326 9.78 CCL20 CCR4 CCR6 CXCR3
14 positive regulation of MAP kinase activity GO:0043406 9.77 ELANE TGFB1 TNF
15 chemokine-mediated signaling pathway GO:0070098 9.76 CCL20 CCR4 CCR6 CXCR3
16 phagocytosis GO:0006909 9.73 ELANE ITGAL ITGB1 ITGB2
17 positive regulation of superoxide anion generation GO:0032930 9.67 ITGB2 TGFB1
18 negative regulation of growth of symbiont in host GO:0044130 9.67 ELANE TNF
19 leukocyte tethering or rolling GO:0050901 9.67 ITGB1 SELE SELPLG TNF
20 pathway-restricted SMAD protein phosphorylation GO:0060389 9.65 SMAD7 TGFB1
21 negative regulation of interleukin-17 production GO:0032700 9.65 IL36RN TGFB1
22 positive regulation of podosome assembly GO:0071803 9.64 IL5 TNF
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 ELANE TNF
24 germ cell migration GO:0008354 9.62 ITGB1 TGFB1
25 response to laminar fluid shear stress GO:0034616 9.62 SMAD7 TGFB1
26 T cell migration GO:0072678 9.61 CCL20 CCR6
27 regulation of immunoglobulin secretion GO:0051023 9.58 CD40LG TNF
28 cellular extravasation GO:0045123 9.57 ITGB2 TNF
29 leukocyte migration involved in inflammatory response GO:0002523 9.56 CCR6 ELANE ITGB2 SELE
30 leukocyte migration GO:0050900 9.56 ELANE ITGAL ITGB1 ITGB2 SELE SELPLG
31 leukocyte cell-cell adhesion GO:0007159 9.55 CD40LG ITGAL ITGB1 ITGB2 SELE
32 positive regulation of mononuclear cell migration GO:0071677 9.54 TGFB1 TNF
33 thymocyte migration GO:0072679 9.52 CCL20 CCR6
34 inflammatory response GO:0006954 9.36 CCL20 CCR4 CD40LG CXCR3 IL36RN IL5
35 cell adhesion GO:0007155 10.02 CXCR3 ITGAL ITGB1 ITGB2 SELE SELPLG
36 immune response GO:0006955 10.01 CCL20 CCR4 CCR6 CD40LG CXCR3 IL36RN

Molecular functions related to Pustulosis Palmaris Et Plantaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.65 ELANE ITGB1 TNF
2 cell adhesion molecule binding GO:0050839 9.61 ITGAL ITGB1 ITGB2
3 chemokine binding GO:0019956 9.54 CCR4 CCR6 CXCR3
4 C-C chemokine binding GO:0019957 9.5 CCR4 CCR6 CXCR3
5 type I transforming growth factor beta receptor binding GO:0034713 9.46 SMAD7 TGFB1
6 ICAM-3 receptor activity GO:0030369 9.4 ITGAL ITGB2
7 C-C chemokine receptor activity GO:0016493 9.33 CCR4 CCR6 CXCR3
8 chemokine receptor activity GO:0004950 9.13 CCR4 CCR6 CXCR3
9 cytokine activity GO:0005125 9.1 CCL20 CD40LG IL36RN IL5 TGFB1 TNF
10 protein binding GO:0005515 10.19 AP1S3 CCL20 CCR4 CCR6 CD40LG CD79A

Sources for Pustulosis Palmaris Et Plantaris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....