MCID: PYL004
MIFTS: 37

Pyelitis

Categories: Nephrological diseases

Aliases & Classifications for Pyelitis

MalaCards integrated aliases for Pyelitis:

Name: Pyelitis 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2744
MeSH 44 D011702
NCIt 50 C34964
SNOMED-CT 67 27174002
ICD10 32 N12
UMLS 70 C0034183

Summaries for Pyelitis

MalaCards based summary : Pyelitis is related to urinary tract infection and cystitis. An important gene associated with Pyelitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Measles. Affiliated tissues include kidney, colon and spinal cord, and related phenotype is homeostasis/metabolism.

Wikipedia : 73 Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most... more...

Related Diseases for Pyelitis

Diseases related to Pyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 692)
# Related Disease Score Top Affiliating Genes
1 urinary tract infection 31.0 UMOD TLR4 LCN2 CRP
2 cystitis 30.9 UPK1A UMOD TNF TLR4 IL6 CXCL8
3 hydronephrosis 30.5 REN IL6 CXCL8 CRP B2M ALB
4 pyelonephritis 30.5 UMOD TNF TLR4 LCN2 IL6 CXCR1
5 purpura 30.5 TNF IL6 CRP
6 pyeloureteritis cystica 30.4 REN CRP
7 congenital anomalies of kidney and urinary tract 2 30.4 UMOD REN LCN2
8 toxic shock syndrome 30.3 TNF TLR4 IL6 CXCL8 CRP
9 pleural empyema 30.3 IL6 CRP ALB
10 neurogenic bladder 30.3 UPK1A CRP ALB
11 appendicitis 30.2 TNF TLR4 IL6 CXCL8 CRP ALB
12 eclampsia 30.2 TNF REN ALB
13 renal tuberculosis 30.2 REN CRP B2M
14 lung abscess 30.2 TNF IL6 CRP ALB
15 proteinuria, chronic benign 30.1 REN B2M ALB
16 anuria 30.1 REN LCN2 CRP ALB
17 disease by infectious agent 30.1 TNF TLR4 SERPINA3 IL6 CRP CCR6
18 granulomatosis with polyangiitis 30.1 TNF TLR4 CRP CCR6
19 prostatitis 30.1 TNF SERPINA3 IL6 CXCL8
20 acute pyelonephritis 30.1 LCN2 IL6 CXCR1 CXCL8 CRP ALB
21 disseminated intravascular coagulation 30.1 TNF IL6 CRP
22 urinary tract obstruction 30.1 UMOD REN LCN2 CRP CCR6 B2M
23 pyuria 30.0 LCN2 IL6 CXCL8 CRP B2M ALB
24 end stage renal disease 30.0 UMOD TNF REN IL6 CRP B2M
25 acute kidney failure 29.8 UMOD REN LCN2 B2M ALB
26 interstitial nephritis 29.8 UMOD REN CRP CCR6 B2M ALB
27 bacteriuria 29.7 UMOD TLR4 IL6 CXCR1 CXCL8 CRP
28 chronic pyelonephritis 29.7 UMOD TLR4 SERPINA3 REN CRP B2M
29 pre-eclampsia 29.7 TNF TLR4 REN IL6 CXCL8 CRP
30 peritonitis 29.6 TNF TLR4 IL6 CXCL8 CRP B2M
31 kidney disease 29.6 UMOD TNF SERPINA3 REN LCN2 IL6
32 pulmonary disease, chronic obstructive 29.6 TNF SERPINA3 IL6 CXCR1 CXCL8 CRP
33 bacterial infectious disease 29.6 TNF TLR4 SERPINA3 LCN2 IL6 CXCL8
34 vesicoureteral reflux 1 29.2 UPK1A UMOD REN OGA LCN2 CXCR1
35 acute cystitis 29.0 UPK1A UMOD TNF TLR4 SLC5A4 SLC5A2
36 chronic duodenal ileus 10.5 CRP ALB
37 cold agglutinin disease 10.5 IL6 CRP
38 peptic ulcer perforation 10.5 CRP ALB
39 ankylosing spondylitis 3 10.4 CRP ALB
40 ankylosing spondylitis 1 10.4 CRP ALB
41 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
42 splenic infarction 10.4 SERPINA3 CRP ALB
43 external pathological resorption 10.4 TNF IL6
44 mucormycosis 10.4 CRP CCR6 ALB
45 clostridium difficile colitis 10.4 CRP CCR6 ALB
46 atypical depressive disorder 10.4 SERPINA3 IL6 CRP
47 tuberculous peritonitis 10.4 CRP ALB
48 heart cancer 10.4 SERPINA3 IL6 CRP
49 autosomal dominant tubulointerstitial kidney disease - ren 10.4 UMOD REN
50 autosomal dominant tubulointerstitial kidney disease 10.4 UMOD REN

Graphical network of the top 20 diseases related to Pyelitis:



Diseases related to Pyelitis

Symptoms & Phenotypes for Pyelitis

MGI Mouse Phenotypes related to Pyelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.47 ALB B2M CCR6 CRP CXCR1 IL6

Drugs & Therapeutics for Pyelitis

Search Clinical Trials , NIH Clinical Center for Pyelitis

Cochrane evidence based reviews: pyelitis

Genetic Tests for Pyelitis

Anatomical Context for Pyelitis

MalaCards organs/tissues related to Pyelitis:

40
Kidney, Colon, Spinal Cord, Skin, Placenta

Publications for Pyelitis

Articles related to Pyelitis:

(show top 50) (show all 422)
# Title Authors PMID Year
1
Chlamydia pecorum-Induced Arthritis in Experimentally and Naturally Infected Sheep. 61
33208021 2021
2
A Case Report on Distinguishing Emphysematous Pyelitis and Pyelonephritis on Point-of-care Ultrasound. 61
33560948 2021
3
CT as a Diagnostic Tool for Emphysematous Pyelitis: A Case Report. 61
33786222 2021
4
Purpura Fulminans in a Patient With Septic Shock due to Escherichia coli Bacteremia With Emphysematous Pyelitis. 61
33717756 2021
5
Encrusted Urinary Tract Infections Due to Corynebacteria Species. 61
33426397 2021
6
Asymptomatic emphysematous pyelitis-a rare clinical entity. 61
33461992 2021
7
Potential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation. 61
31989448 2020
8
Renal failure due to encrusted cystitis and pyelitis. 61
32743486 2020
9
An Unexpected Complication After Extracorporeal Shock Wave Lithotripsy: Emphysematous Pyelitis. 61
32607291 2020
10
Unexpected emphysematous cystitis and pyelitis. 61
32111714 2020
11
Oral Acidification with l-Methionine as a Noninvasive Treatment for Encrusted Uropathy. 61
33102711 2020
12
Encrusted pyelitis in a kidney allograft. 61
31901347 2020
13
Gas-Containing Renal Matrix Stones in a Patient with Emphysematous Pyelitis Treated with Delayed Percutaneous Nephrolithotomy. 61
33457697 2020
14
The importance of surgical treatment in encrusted cystitis and pyelitis: A case report. 61
33221567 2020
15
Alkaline-Encrusted Pyelitis Causing Renal Failure in a Transplant Kidney: Treatment with Percutaneous Nephrolithotomy and Urinary Acidification. 61
33457694 2020
16
Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis. 61
31870084 2019
17
Arcanobacterium pyogenes and encrusted pyelitis. 61
31915531 2019
18
Emphysematous pyelitis in a solitary functioning kidney. 61
31211095 2019
19
Alkaline-encrusting pyelitis - A rare disastrous complication postPCNL leading to chronic renal failure. 61
31367080 2019
20
Gas in the kidney in asymptomatic Escherichia coli urinary tract infections in a patient with severe vesicoureteral reflex. 61
31249237 2019
21
Alkaline-Encrusted Pyelitis in a Renal Allograft. 61
30596183 2019
22
Brodifacoum-contaminated synthetic marijuana: clinical and radiologic manifestations of a public health outbreak causing life-threatening coagulopathy. 61
30022308 2018
23
Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound. 61
30524681 2018
24
[Encrusted Pyelitis during a case of Thrombotic Thrombocytopenic Purpura]. 61
30234234 2018
25
Air bubbles in the urinary tract. Incidental and asymptomatic combined emphysematous pyelitis, ureteritis and cystitis. A rare case report and review of the literature. 61
29785361 2018
26
Foley Follies: Emphysematous Pyelitis from Instrumentation in Obstructive Uropathy. 61
29098124 2017
27
Emphysematous Pyelitis: An Entity Distinct from Emphysematous Pyelonephritis. 61
28502342 2017
28
Appearance of Pyelitis Emphysematosa on Computed Tomography. 61
27993715 2017
29
Absence of HIV-Associated Nephropathy Among Antiretroviral Naive Adults With Persistent Albuminuria in Western Kenya. 61
29142953 2017
30
Pseudotuberculous Granulomatous Pyelitis. 61
27440812 2017
31
[Results of conservative management of emphysematous pyelonephritis]. 61
27789323 2016
32
Computed tomography findings associated with bacteremia in adult patients with a urinary tract infection. 61
27502931 2016
33
Encrusted Uretero-pyelitis: Case Report. 61
27335796 2016
34
Emphysematous pyelitis and cystitis associated with vesicoureteral reflux in a diabetic dog. 61
27041755 2016
35
Corinebacterium urealyticum: increased incidence of infection and encrusted uropathy. 61
26585531 2016
36
"I have chicken fat in my urine!" A case of Candida tropicalis induced emphysematous pyelitis. 61
26909246 2015
37
A Rare Case of Pneumoureter: Emphysematous Pyelitis versus Emphysematous Pyelonephritis. 61
26676155 2015
38
IgG4-related kidney disease--an update. 61
25594543 2015
39
67Ga SPECT/CT of infected bladder stones and pyelitis. 61
25546213 2015
40
IgG4-related Disease: A Mass Lesion in the Intrarenal Sinus near the Renal Pelvis. 61
26234232 2015
41
Emphysematous pyelitis. 61
25266345 2015
42
Emphysematous cystitis with concomitant bilateral emphysematous ureteritis and pyelitis in a diabetic patient. 61
26175815 2015
43
Plagiarism in the article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini et al. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505). 61
26328003 2015
44
Genome informatics and vaccine targets in Corynebacterium urealyticum using two whole genomes, comparative genomics, and reverse vaccinology. 61
26041051 2015
45
Histopathologic lesions in conventional pigs experimentally infected with Haemophilus parasuis serovar 5. 61
25782571 2015
46
Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study. 61
25300826 2014
47
Carbonate apatite nephrolithiasis associated with Corynebacterium urealyticum urinary tract infection in a dog. 61
24766046 2014
48
Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder. 61
23753628 2013
49
Struvite urolithiasis and chronic urinary tract infection in a murine model of urinary diversion. 61
23523293 2013
50
Complicated urinary tract infections associated with diabetes mellitus: Pathogenesis, diagnosis and management. 61
23869299 2013

Variations for Pyelitis

Expression for Pyelitis

Search GEO for disease gene expression data for Pyelitis.

Pathways for Pyelitis

Pathways related to Pyelitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TNF TLR4 SERPINA3 RNASE7 LCN2 IL6
2
Show member pathways
12.72 TNF TLR4 IL6 CXCL8 B2M
3
Show member pathways
12.23 TNF LCN2 IL6 CXCL8
4
Show member pathways
12.16 TNF TLR4 IL6 CXCL8
5
Show member pathways
12.14 TNF IL6 CXCR1 CXCL8 CCR6
6 12.13 TNF TLR4 IL6 CXCL8
7
Show member pathways
12.1 TNF SERPINA3 IL6 CRP ALB
8
Show member pathways
12.05 TNF TLR4 IL6 CXCL8
9 11.96 TNF TLR4 IL6 CXCL8
10 11.87 TNF TLR4 IL6 CXCL8
11 11.84 TNF LCN2 IL6 CXCL8
12 11.77 TNF TLR4 IL6 CXCL8
13 11.7 TNF TLR4 IL6 CXCL8
14
Show member pathways
11.66 TNF TLR4 IL6
15
Show member pathways
11.57 TNF IL6 CXCL8
16 11.56 TNF IL6 CXCL8
17 11.5 TNF TLR4 IL6 CXCL8
18 11.44 IL6 CXCR1 CXCL8
19 11.41 TNF IL6 CXCL8
20 11.38 TNF TLR4 IL6 CCR6
21 11.23 TNF TLR4 IL6
22 11.21 TNF TLR4 IL6 CXCL8
23 10.96 TNF TLR4 IL6 CXCL8
24 10.2 TNF IL6 CXCL8 CRP

GO Terms for Pyelitis

Cellular components related to Pyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 UMOD TNF SERPINA3 RNASE7 REN LCN2
2 external side of plasma membrane GO:0009897 9.65 TNF TLR4 CXCR1 CCR6 B2M
3 cell surface GO:0009986 9.63 UPK1A UMOD TNF TLR4 CCR6 B2M
4 extracellular space GO:0005615 9.36 UMOD TNF SERPINA3 RNASE7 REN LCN2

Biological processes related to Pyelitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 TNF TLR4 LCN2 IL6 CXCL8 CRP
2 apoptotic signaling pathway GO:0097190 9.75 UMOD TNF TLR4
3 chemokine-mediated signaling pathway GO:0070098 9.74 CXCR1 CXCL8 CCR6
4 defense response to Gram-positive bacterium GO:0050830 9.73 TNF RNASE7 IL6 CRP
5 positive regulation of interleukin-8 production GO:0032757 9.71 TNF TLR4 IL6
6 humoral immune response GO:0006959 9.7 TNF IL6 CCR6
7 immune response GO:0006955 9.7 TNF TLR4 IL6 CXCR1 CXCL8 CCR6
8 positive regulation of interleukin-1 beta production GO:0032731 9.69 TNF TLR4 IL6
9 positive regulation of chemokine production GO:0032722 9.67 TNF TLR4 IL6
10 acute-phase response GO:0006953 9.65 SERPINA3 IL6 CRP
11 cellular response to lipopolysaccharide GO:0071222 9.65 TNF TLR4 LCN2 IL6 CXCL8
12 defense response to Gram-negative bacterium GO:0050829 9.62 UMOD TLR4 RNASE7 IL6
13 response to molecule of bacterial origin GO:0002237 9.59 CXCL8 B2M
14 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.58 TNF TLR4
15 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6 B2M
16 cellular response to nicotine GO:0071316 9.56 TNF B2M
17 vascular endothelial growth factor production GO:0010573 9.55 TNF IL6
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 TNF TLR4 IL6
19 inflammatory response GO:0006954 9.17 UMOD TNF TLR4 SERPINA3 IL6 CXCL8
20 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP

Molecular functions related to Pyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose:sodium symporter activity GO:0005412 8.96 SLC5A4 SLC5A2
2 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Pyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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