MCID: PYL004
MIFTS: 40

Pyelitis

Categories: Nephrological diseases

Aliases & Classifications for Pyelitis

MalaCards integrated aliases for Pyelitis:

Name: Pyelitis 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2744
MeSH 43 D011702
NCIt 49 C34964
SNOMED-CT 67 27174002
ICD10 32 N12
UMLS 71 C0034183

Summaries for Pyelitis

MalaCards based summary : Pyelitis is related to cystitis and hydronephrosis. An important gene associated with Pyelitis is PAPOLG (Poly(A) Polymerase Gamma), and among its related pathways/superpathways are Innate Immune System and IL-17 Family Signaling Pathways. The drugs Selenium and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most... more...

Related Diseases for Pyelitis

Diseases related to Pyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 695)
# Related Disease Score Top Affiliating Genes
1 cystitis 31.1 UPK1A UMOD TNF TLR4 IL6 CXCL8
2 hydronephrosis 31.0 REN IL6 CXCL8 CRP ALB
3 pyeloureteritis cystica 30.9 REN CRP
4 urolithiasis 30.9 UMOD IL6 ALB
5 congenital anomalies of kidney and urinary tract 2 30.8 UMOD REN LCN2
6 renal tuberculosis 30.8 REN NEXMIF CRP
7 pleural empyema 30.8 CRP CD40LG ALB
8 hemorrhagic cystitis 30.7 TNF TLR4 ALB
9 end stage renal disease 30.6 UMOD TNF REN IL6 CRP ALB
10 pyelonephritis 30.5 UMOD TNF TLR4 LCN2 IL6 CXCR1
11 appendicitis 30.5 TNF TLR4 IL6 CXCL8 CRP ALB
12 eclampsia 30.5 TNF REN IL6 ALB
13 purpura 30.5 TNF IL6 CRP CD40LG
14 prostatitis 30.5 TNF SERPINA3 IL6 CXCL8
15 acute kidney failure 30.5 UMOD REN LCN2 ALB
16 acute pyelonephritis 30.4 LCN2 IL6 CXCR1 CXCL8 CRP ALB
17 urinary tract obstruction 30.3 UMOD TNF REN LCN2 CRP CCR6
18 pyuria 30.3 LCN2 IL6 CXCL8 CRP CD40LG ALB
19 anuria 30.3 REN LCN2 CRP CD40LG ALB
20 interstitial nephritis 30.2 UMOD REN CRP CD40LG CCR6 ALB
21 toxic shock syndrome 30.1 TNF TLR4 IL6 CXCL8 CRP CD40LG
22 kidney disease 30.0 UMOD SERPINA3 REN LCN2 IL6 CRP
23 chronic pyelonephritis 30.0 UMOD TLR4 SERPINA3 REN NEXMIF CRP
24 vesicoureteral reflux 1 29.9 UPK1A UMOD REN LCN2 CXCR1 CXCL8
25 pre-eclampsia 29.6 TNF TLR4 REN IL6 CXCL8 CRP
26 bacteriuria 29.6 UMOD TLR4 PAPOLG IL6 CXCR1 CXCL8
27 acute cystitis 29.0 UPK1A UMOD TNF TLR4 SERPINA3 REN
28 chronic duodenal ileus 10.7 CRP ALB
29 cold agglutinin disease 10.6 IL6 CRP
30 autosomal dominant tubulointerstitial kidney disease, ren-related 10.6 UMOD REN
31 autosomal dominant tubulointerstitial kidney disease 10.6 UMOD REN
32 prosthetic joint infection 10.6 TLR4 IL6 CRP
33 cryopyrin-associated periodic syndrome 10.6 IL6 CRP
34 cork-handlers' disease 10.6 CD40LG ALB
35 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
36 atypical depressive disorder 10.6 SERPINA3 IL6 CRP
37 external pathological resorption 10.6 TNF IL6
38 acute cholangitis 10.6 IL6 CRP ALB
39 uremic pruritus 10.6 IL6 CRP
40 xanthogranulomatous pyelonephritis 10.6 SERPINA3 NEXMIF
41 acute adrenal insufficiency 10.6 REN IL6
42 gas gangrene 10.6 SERPINA3 IL6 CRP
43 systemic autoimmune disease 10.6 IL6 CRP
44 scorpion envenomation 10.6 TNF IL6
45 fournier gangrene 10.6 CD40LG ALB
46 mikulicz disease 10.5 CRP CD40LG CCR6
47 acute transverse myelitis 10.5 IL6 CXCL8
48 intestinal tuberculosis 10.5 TNF CRP ALB
49 heterophyiasis 10.5 CD40LG ALB
50 splenic abscess 10.5 CRP CD40LG ALB

Graphical network of the top 20 diseases related to Pyelitis:



Diseases related to Pyelitis

Symptoms & Phenotypes for Pyelitis

GenomeRNAi Phenotypes related to Pyelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CD40LG CXCL8 LCN2 REN TNF UMOD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CXCL8 LCN2 REN TNF UMOD
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.4 UMOD

MGI Mouse Phenotypes related to Pyelitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ALB CCR6 CD40LG CRP CXCR1 IL6
2 cardiovascular system MP:0005385 9.96 ALB CCR6 CD40LG CRP IL6 LCN2
3 immune system MP:0005387 9.73 ALB CCR6 CD40LG CPN1 CRP IL6
4 renal/urinary system MP:0005367 9.23 ALB CD40LG IL6 LCN2 NEXMIF REN

Drugs & Therapeutics for Pyelitis

Drugs for Pyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
2 Antioxidants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Chronic HCV Infected Egyptian Patients With Electromagnetic Waves and Herbal Therapy Unknown status NCT02215525 Phase 3

Search NIH Clinical Center for Pyelitis

Cochrane evidence based reviews: pyelitis

Genetic Tests for Pyelitis

Anatomical Context for Pyelitis

MalaCards organs/tissues related to Pyelitis:

40
Kidney, Colon, Prostate, Testes, Spinal Cord, Liver, Skin

Publications for Pyelitis

Articles related to Pyelitis:

(show top 50) (show all 390)
# Title Authors PMID Year
1
Unexpected emphysematous cystitis and pyelitis. 61
32111714 2020
2
Encrusted pyelitis in a kidney allograft. 61
31901347 2020
3
Potential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation. 61
31989448 2020
4
Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis. 61
31870084 2019
5
Arcanobacterium pyogenes and encrusted pyelitis. 61
31915531 2019
6
Emphysematous pyelitis in a solitary functioning kidney. 61
31211095 2019
7
Alkaline-encrusting pyelitis - A rare disastrous complication postPCNL leading to chronic renal failure. 61
31367080 2019
8
Gas in the kidney in asymptomatic Escherichia coli urinary tract infections in a patient with severe vesicoureteral reflex. 61
31249237 2019
9
Alkaline-Encrusted Pyelitis in a Renal Allograft. 61
30596183 2019
10
Brodifacoum-contaminated synthetic marijuana: clinical and radiologic manifestations of a public health outbreak causing life-threatening coagulopathy. 61
30022308 2018
11
Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound. 61
30524681 2018
12
[Encrusted Pyelitis during a case of Thrombotic Thrombocytopenic Purpura]. 61
30234234 2018
13
Air bubbles in the urinary tract. Incidental and asymptomatic combined emphysematous pyelitis, ureteritis and cystitis. A rare case report and review of the literature. 61
29785361 2018
14
Foley Follies: Emphysematous Pyelitis from Instrumentation in Obstructive Uropathy. 61
29098124 2017
15
Emphysematous Pyelitis: An Entity Distinct from Emphysematous Pyelonephritis. 61
28502342 2017
16
Absence of HIV-Associated Nephropathy Among Antiretroviral Naive Adults With Persistent Albuminuria in Western Kenya. 61
29142953 2017
17
Appearance of Pyelitis Emphysematosa on Computed Tomography. 61
27993715 2017
18
Pseudotuberculous Granulomatous Pyelitis. 61
27440812 2017
19
[Results of conservative management of emphysematous pyelonephritis]. 61
27789323 2016
20
Computed tomography findings associated with bacteremia in adult patients with a urinary tract infection. 61
27502931 2016
21
Encrusted Uretero-pyelitis: Case Report. 61
27335796 2016
22
Emphysematous pyelitis and cystitis associated with vesicoureteral reflux in a diabetic dog. 61
27041755 2016
23
Corinebacterium urealyticum: increased incidence of infection and encrusted uropathy. 61
26585531 2016
24
"I have chicken fat in my urine!" A case of Candida tropicalis induced emphysematous pyelitis. 61
26909246 2015
25
A Rare Case of Pneumoureter: Emphysematous Pyelitis versus Emphysematous Pyelonephritis. 61
26676155 2015
26
67Ga SPECT/CT of infected bladder stones and pyelitis. 61
25546213 2015
27
IgG4-related kidney disease--an update. 61
25594543 2015
28
IgG4-related Disease: A Mass Lesion in the Intrarenal Sinus near the Renal Pelvis. 61
26234232 2015
29
Histopathologic lesions in conventional pigs experimentally infected with Haemophilus parasuis serovar 5. 61
25782571 2015
30
Genome informatics and vaccine targets in Corynebacterium urealyticum using two whole genomes, comparative genomics, and reverse vaccinology. 61
26041051 2015
31
Plagiarism in the article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini et al. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505). 61
26328003 2015
32
Emphysematous cystitis with concomitant bilateral emphysematous ureteritis and pyelitis in a diabetic patient. 61
26175815 2015
33
Emphysematous pyelitis. 61
25266345 2015
34
Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study. 61
25300826 2014
35
Carbonate apatite nephrolithiasis associated with Corynebacterium urealyticum urinary tract infection in a dog. 61
24766046 2014
36
Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder. 61
23753628 2013
37
Complicated urinary tract infections associated with diabetes mellitus: Pathogenesis, diagnosis and management. 61
23869299 2013
38
Struvite urolithiasis and chronic urinary tract infection in a murine model of urinary diversion. 61
23523293 2013
39
Ileo-pelvic anastomosis and augmentation cystoplasty for treatment of encrusted pyelitis in a transplanted kidney. 61
23550263 2013
40
Bilateral emphysematous pyelitis: a rare encounter in urology. 61
24045515 2013
41
Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. 61
24498467 2013
42
Emphysematous urinoma as a complication of emphysematous pyelitis in a healthy adult male. 61
22739565 2012
43
[Constant renewal of the investigation and management of small children with pyelitis]. 61
22913119 2012
44
Genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. 61
22786992 2012
45
Encrusted cystitis and pyelitis. 61
22616968 2012
46
Clinics in diagnostic imaging (138). Emphysematous pyelitis. 61
22434298 2012
47
Histological changes in kidney and liver of rats due to gold (III) compound [Au(en)Cl(2)]Cl. 61
23300573 2012
48
[New principles from American Pediatric Society. Investigation of small children with pyelitis needs to be renewed]. 61
22468400 2011
49
Emphysematous pyelonephritis in decompensated diabetes: a case report and review of the literature. 61
21826886 2011
50
Renal lesions of nondomestic felids. 61
20876911 2011

Variations for Pyelitis

Expression for Pyelitis

Search GEO for disease gene expression data for Pyelitis.

Pathways for Pyelitis

Pathways related to Pyelitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR4 SERPINA3 RNASE7 LCN2 IL6
2
Show member pathways
12.25 TNF LCN2 IL6 CXCL8
3 12.22 TNF TLR4 IL6 CXCL8
4 12.18 TNF TLR4 IL6 CXCL8
5
Show member pathways
12.16 TNF TLR4 IL6 CXCL8
6
Show member pathways
12.14 TNF IL6 CXCR1 CXCL8 CCR6
7 12.13 TNF TLR4 IL6 CXCL8
8
Show member pathways
12.1 TNF SERPINA3 IL6 CRP ALB
9
Show member pathways
12.07 TNF TLR4 IL6 CXCL8
10 11.9 TNF TLR4 IL6 CXCL8
11 11.89 TNF TLR4 IL6 CXCL8
12 11.85 TNF LCN2 IL6 CXCL8
13 11.8 TNF TLR4 CXCL8 CD40LG
14 11.77 TNF TLR4 IL6 CXCL8
15 11.7 TNF TLR4 IL6 CXCL8
16
Show member pathways
11.67 TNF CXCL8 CD40LG
17 11.57 TNF IL6 CXCL8
18 11.5 TNF TLR4 IL6 CXCL8
19 11.45 IL6 CXCR1 CXCL8
20 11.42 TNF IL6 CXCL8
21
Show member pathways
11.36 TNF IL6 CXCL8 CD40LG
22 11.26 TNF TLR4 IL6
23 11.21 TNF TLR4 IL6 CXCL8
24 10.72 TNF TLR4 IL6 CXCL8 CD40LG
25 10.54 TNF IL6 CXCL8 CRP

GO Terms for Pyelitis

Cellular components related to Pyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 UMOD TNF SERPINA3 RNASE7 REN LCN2
2 external side of plasma membrane GO:0009897 9.65 TNF TLR4 CXCR1 CD40LG CCR6
3 cell surface GO:0009986 9.63 UPK1A UMOD TNF TLR4 CD40LG CCR6
4 extracellular space GO:0005615 9.4 UMOD TNF SERPINA3 RNASE7 REN LCN2

Biological processes related to Pyelitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 TNF TLR4 LCN2 IL6 CRP
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 TNF TLR4 IL6 CD40LG
3 chemokine-mediated signaling pathway GO:0070098 9.71 CXCR1 CXCL8 CCR6
4 defense response to Gram-positive bacterium GO:0050830 9.71 TNF RNASE7 IL6 CRP
5 response to glucocorticoid GO:0051384 9.7 TNF IL6 CPN1
6 humoral immune response GO:0006959 9.69 TNF IL6 CCR6
7 positive regulation of interleukin-6 production GO:0032755 9.67 TNF TLR4 IL6
8 cellular response to lipopolysaccharide GO:0071222 9.65 TNF TLR4 LCN2 IL6 CXCL8
9 acute-phase response GO:0006953 9.61 SERPINA3 IL6 CRP
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 TNF TLR4 IL6
11 positive regulation of chemokine production GO:0032722 9.5 TNF TLR4 IL6
12 immune response GO:0006955 9.5 TNF TLR4 IL6 CXCR1 CXCL8 CD40LG
13 regulation of immunoglobulin secretion GO:0051023 9.48 TNF CD40LG
14 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
15 inflammatory response GO:0006954 9.17 TNF TLR4 SERPINA3 IL6 CXCL8 CRP

Molecular functions related to Pyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 CXCL8 CD40LG
2 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Pyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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