Pyelonephritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PYL005 MIFTS: 56	Pyelonephritis Categories: Nephrological diseases
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Aliases & Classifications for Pyelonephritis

MalaCards integrated aliases for Pyelonephritis:

Name: Pyelonephritis ¹² ⁷⁶ ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the genitourinary system

Renal tubulo-interstitial diseases

Renal tubulo-interstitial disorders in diseases classified elsewhere

Tubulo-interstitial nephritis, not specified as acute or chronic

External Ids:

Disease Ontology ¹² DOID:11400

ICD10 ³³ N10-N16 N12 N16

ICD9CM ³⁵ 590.80

MeSH ⁴⁴ D011704

NCIt ⁵⁰ C34965

SNOMED-CT ⁶⁸ 197779009 197784003 45816000

UMLS ⁷³ C0034186

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Summaries for Pyelonephritis

MalaCards based summary : Pyelonephritis is related to pyelitis and acute cystitis. An important gene associated with Pyelonephritis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : ⁷⁶ Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most... more...

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Related Diseases for Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis

Acute Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 472)

#	Related Disease	Score	Top Affiliating Genes
1	pyelitis	32.8	CRP CXCR1 TLR4
2	acute cystitis	31.8	ALB CCL2 CRP CXCL8 IL6
3	hydronephrosis	30.7	ALB CCL2 NAGLU
4	pyuria	30.7	ALB CRP CXCL8
5	fasciitis	30.6	CXCL8 IL6 TNF
6	septic arthritis	30.3	CRP CXCL8 TLR4
7	infective endocarditis	30.1	CRP IL6 TNF
8	vaginitis	30.0	CXCL8 IL1B IL6
9	endometriosis	30.0	CCL2 CXCL8 IL6
10	spondylitis	30.0	CRP IL6 TNF
11	glomerulonephritis	30.0	ALB CCL2 IL1B
12	bacteriuria	29.9	CXCL8 CXCR1 CXCR2 IL6 TLR4
13	osteomyelitis	29.9	CXCL8 IL1B IL6 TNF
14	bronchitis	29.9	ALB CXCL8 TNF
15	haemophilus influenzae	29.8	CXCL8 IL1B TNF
16	acute pyelonephritis	29.8	ALB CRP CXCL8 CXCR1 CXCR2 IL10
17	salmonellosis	29.7	ALB IL1B TLR4
18	cerebral palsy	29.7	IL1B IL6 TNF
19	acute kidney tubular necrosis	29.6	ALB NAGLU UMOD
20	cholangitis	29.6	ALB CRP IL6 TNF
21	posterior urethral valves	29.4	ACE IL6 TNF
22	interstitial nephritis	29.4	ACE ALB CRP UMOD
23	cystitis	29.4	CRP CXCL8 IL6 TLR4 TNF UMOD
24	placenta disease	29.4	CXCL8 IL1B IL6 PGF
25	eclampsia	29.3	ALB PGF TNF
26	autosomal dominant polycystic kidney disease	29.3	ACE ALB CCL2
27	myeloma, multiple	29.2	ALB CRP CXCL8 IL6 TNF
28	urinary tract obstruction	29.1	ALB CCL2 NAGLU UMOD
29	chronic kidney failure	28.6	ACE ALB CRP IL6 UMOD
30	melioidosis	28.6	IL10 IL6 TLR4 TNF
31	prostatitis	28.6	CXCL8 IL10 IL1B IL6 TNF
32	diabetes mellitus	28.4	ACE ALB CRP IL1B IL6 TNF
33	kidney disease	28.2	ACE ALB CCL2 CRP NAGLU UMOD
34	adult respiratory distress syndrome	27.9	ACE CXCL8 IL10 IL6 TNF
35	end stage renal failure	27.8	ACE ALB CRP IL6 TNF UMOD
36	brucellosis	27.8	CRP CXCL8 IL10 IL6 TLR4 TNF
37	endocarditis	27.8	ALB CRP CXCL8 IL10 IL6 TNF
38	arthritis	27.7	CCL2 CXCL8 IL10 IL1B IL6 TNF
39	heart disease	27.7	ACE ALB CRP IL1B IL6 TNF
40	colitis	27.7	CXCL8 IL10 IL1B IL6 TLR4 TNF
41	arteriosclerosis	27.7	ACE CCL2 CRP IL10 IL6
42	kawasaki disease	27.6	ALB CCL2 CRP IL10 IL6 TNF
43	crohn's disease	27.5	CRP IL10 IL1B IL6 TLR4 TNF
44	systemic lupus erythematosus	27.4	ALB CCL2 CRP IL10 IL6 TNF
45	appendicitis	27.3	ALB CRP CXCL8 IL10 IL1B IL6
46	gastroenteritis	27.0	ALB CRP CXCL8 IL10 IL1B IL6
47	pneumonia	27.0	CCL2 CRP CXCL8 IL10 IL1B IL6
48	rheumatoid arthritis	26.7	CCL2 CRP CXCL8 IL10 IL1B IL6
49	xanthogranulomatous pyelonephritis	12.2
50	chronic pyelonephritis	12.2

Comorbidity relations with Pyelonephritis via Phenotypic Disease Network (PDN): (show all 22)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Alzheimer Disease
Chronic Kidney Failure	Chronic Myocardial Ischemia
Cystitis	Decubitus Ulcer
Deficiency Anemia	Esophagitis
Heart Disease	Hydronephrosis
Hypertension, Essential	Hypothyroidism
Iron Deficiency Anemia	Kidney Disease
Nephrolithiasis, X-Linked Recessive, with Renal Failure	Osteoporosis
Paralytic Ileus	Protein-Energy Malnutrition
Schizophreniform Disorder	Ureterolithiasis

Graphical network of the top 20 diseases related to Pyelonephritis:

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Symptoms & Phenotypes for Pyelonephritis

GenomeRNAi Phenotypes related to Pyelonephritis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.7	ACE CXCL8 IL10 IL1B TNF UMOD
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.7	ACE CXCL8 IL10 IL1B TNF UMOD

MGI Mouse Phenotypes related to Pyelonephritis:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.22	ACE IL10 IL1B CCL2 CRP CXCR1
2	cardiovascular system	MP:0005385	10.19	ACE IL10 IL1B CRP IL6 CXCR2
3	growth/size/body region	MP:0005378	10.18	CXCR2 IL6 IL10 ACE IL1B TLR4
4	homeostasis/metabolism	MP:0005376	10.17	IL10 ACE ALB IL1B CRP IL6
5	hematopoietic system	MP:0005397	10.11	CXCR2 ACE IL10 IL1B CXCR1 IL6
6	adipose tissue	MP:0005375	9.99	IL6 ACE TLR4 TNF PGF UMOD
7	liver/biliary system	MP:0005370	9.92	ACE IL10 ALB IL6 CXCR2 NAGLU
8	integument	MP:0010771	9.91	IL10 IL1B IL6 TLR4 NAGLU TNF
9	neoplasm	MP:0002006	9.91	ACE IL10 ALB IL1B IL6 CXCR2
10	renal/urinary system	MP:0005367	9.7	ACE ALB IL6 CXCR2 NAGLU UMOD
11	skeleton	MP:0005390	9.56	CXCR2 IL6 IL10 IL1B TLR4 NAGLU
12	vision/eye	MP:0005391	9.17	CXCR2 IL10 IL6 TLR4 NAGLU TNF

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Drugs & Therapeutics for Pyelonephritis

Drugs for Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cefixime

Approved, Investigational

Phase 4,Phase 1

79350-37-1

54362 5362065

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530 5361919

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2

85721-33-1

2764

Levofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2

100986-85-4

149096

Ofloxacin

Approved

Phase 4,Phase 3,Phase 2

82419-36-1

4583

Nitrofurantoin

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

67-20-9

5353830

Sulfamethoxazole

Approved

Phase 4,Phase 3,Not Applicable

723-46-6

5329

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

738-70-5

5578

Menthol

Approved

Phase 4,Not Applicable

2216-51-5

16666

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Amoxicillin

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

26787-78-0

33613

Fosfomycin

Approved

Phase 4,Phase 2,Phase 3

23155-02-4

446987

Cilastatin

Approved, Investigational

Phase 4,Phase 2

82009-34-5

5280454 6435415

Imipenem

Approved

Phase 4,Phase 2

74431-23-5, 64221-86-9

104838

Cephalexin

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

15686-71-2

27447

Azithromycin

Approved

Phase 4

83905-01-5

55185 447043

Cefuroxime

Approved

Phase 4,Not Applicable

55268-75-2

5361202 5479529

Metronidazole

Approved

Phase 4

443-48-1

4173

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ketoprofen

Approved, Vet_approved

Phase 4

22071-15-4

3825

Cefotaxime

Approved

Phase 4,Not Applicable

63527-52-6

456256 5742673

Cefoxitin

Approved

Phase 4,Not Applicable

35607-66-0

441199

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 3,Not Applicable

59-30-3

6037

leucovorin

Approved, Nutraceutical

Phase 4,Phase 3,Not Applicable

58-05-9

143 6006

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antibiotics, Antitubercular

Phase 4,Phase 3,Phase 2,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antitubercular Agents

Phase 4,Phase 3,Not Applicable

Fluoroquinolones

Phase 4,Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 2

Topoisomerase Inhibitors

Phase 4,Phase 3,Phase 2

Analgesics

Phase 4,Phase 1,Phase 2

Analgesics, Non-Narcotic

Phase 4,Phase 1,Phase 2

Anti-Inflammatory Agents

Phase 4,Phase 1,Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 1,Phase 2

Antirheumatic Agents

Phase 4,Phase 1,Phase 2

Peripheral Nervous System Agents

Phase 4,Phase 1,Phase 2

HIV Protease Inhibitors

Phase 4,Phase 2

protease inhibitors

Phase 4,Phase 2

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4,Phase 3,Phase 2

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Renal Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Antimalarials

Phase 4,Phase 3,Not Applicable

Antiparasitic Agents

Phase 4,Phase 3,Not Applicable

Antiprotozoal Agents

Phase 4,Phase 3,Not Applicable

Folic Acid Antagonists

Phase 4,Phase 3,Not Applicable

Trimethoprim, Sulfamethoxazole Drug Combination

Phase 4,Phase 3,Not Applicable

Vitamin B Complex

Phase 4,Phase 3,Not Applicable

Lactams

Phase 4

Amdinocillin Pivoxil

Phase 4

Interventional clinical trials:

(show top 50) (show all 119)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women	Completed	NCT01390623	Phase 4	Ceftriaxone
2	Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old	Completed	NCT00136656	Phase 4	antibiotic;antibiotics
3	Treatment's Duration of Acute Uncomplicated Pyelonephritis	Completed	NCT00873626	Phase 4	levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4	A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux	Completed	NCT00382343	Phase 4	Sulfamethoxazole/trimethoprim
5	Pharmacokinetics of Ciprofloxacin in Pediatric Patients	Completed	NCT02598362	Phase 4	ciprofloxacin
6	Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication	Completed	NCT02246361	Phase 4
7	Febrile Urinary Tract Infection Randomized Short Treatment Trial	Completed	NCT00809913	Phase 4	short treatment (ciprofloxacin)
8	Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aerugi	Completed	NCT00481689	Phase 4	Cipro XR (Ciprofloxacin, BAYQ3939)
9	Study of Tomography of Nephrolithiasis Evaluation	Completed	NCT01451931	Phase 4
10	Ibuprofen Versus Mecillinam for Uncomplicated Cystitis	Completed	NCT01849926	Phase 4	Ibuprofen;Mecillinam
11	Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis	Recruiting	NCT03179384	Phase 4	Ceftriaxone
12	Treating Pyelonephritis an Urosepsis With Pivmecillinam	Recruiting	NCT03282006	Phase 4	pivmecillinam
13	Management of Sub-Clinical Bacteriuria in Pregnancy	Recruiting	NCT03275623	Phase 4	Antibiotic
14	Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries	Recruiting	NCT03248297	Phase 4	Azithromycin;Azithromycin and amoxicillin;Placebo
15	Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial	Recruiting	NCT03151603	Phase 4	Arctuvan;Fosfomycin;Placebo to Arctuvan;Placebo to Fosfomycin
16	The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria	Recruiting	NCT01871753	Phase 4
17	Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh	Recruiting	NCT02226887	Phase 4
18	Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis	Recruiting	NCT02505581	Phase 4	Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
19	Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy.	Not yet recruiting	NCT03228108	Phase 4	Ciprofloxacin;Trimethoprim/Sulfamethoxazole;Fosfomycin;Pivmecillinam/augmentin
20	Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations	Suspended	NCT01685658	Phase 4	Intravenous ketoprofen;Intravenous paracetamol
21	Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin	Terminated	NCT00239161	Phase 4	Levofloxacin
22	Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli	Terminated	NCT02474706	Phase 4	Cefoxitin;imipenem
23	L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis	Unknown status	NCT02007889	Phase 3	L-carnitine
24	Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children	Unknown status	NCT02192580	Phase 3	Omega-3
25	Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis	Completed	NCT00210990	Phase 3	doripenem
26	Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis	Completed	NCT00229021	Phase 3	doripenum
27	Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis	Completed	NCT01345929	Phase 3	CXA-201;Levofloxacin
28	A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis.	Completed	NCT00210886	Phase 3	levofloxacin
29	Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)	Completed	NCT02728089	Phase 3	MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g)
30	Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)	Completed	NCT01599806	Phase 3	Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
31	Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)	Completed	NCT01595438	Phase 3	Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
32	A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)	Completed	NCT02486627	Phase 3	plazomicin;meropenem;levofloxacin (oral)
33	Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP	Completed	NCT02166476	Phase 3	Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
34	CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria	Completed	NCT03477422	Phase 3	CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
35	Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections	Completed	NCT02753946	Phase 2, Phase 3	ZTI-01;Piperacillin-tazobactam
36	A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED)	Completed	NCT00379964	Phase 3	caspofungin acetate
37	A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048)	Completed	NCT00379951	Phase 3	ertapenem sodium
38	A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections	Completed	NCT00258089	Phase 3	Levofloxacin
39	Queen's University Investigation of Calcification in Chronic Kidney Disease	Completed	NCT00687661	Phase 3	Bisphosphonate;Placebo
40	Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO)	Completed	NCT00495651	Phase 3	Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
41	A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)	Completed	NCT01970371	Phase 3	plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
42	Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults	Completed	NCT02168946	Phase 3	Vabomere;Best Available Therapy
43	Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children	Recruiting	NCT00367159	Phase 3
44	Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections	Not yet recruiting	NCT03543436	Phase 3	Temocillin;meropenem or imipenem
45	Short-term Antibiotic Therapy for Pyelonephritis in Childhood	Terminated	NCT00724256	Phase 3	ceftibuten;ceftibuten
46	A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections	Terminated	NCT01110408	Phase 3	Doripenem;Doripenem placebo;Cefepime;Cefepime placebo;Amoxicillin/clavulanate potassium
47	An Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections	Terminated	NCT02302092	Phase 3	Flomoxef;Cefepime
48	Efficacy of Antimicrobial Prophylaxis for Shock Wave Lithotripsy (SWL) on Reducing Urinary Tract Infection (UTI)	Terminated	NCT01873690	Phase 3	Ciprofloxacin;Placebo
49	Antibiotic Prophylaxis in Children With Pyelonephritis	Withdrawn	NCT00752375	Phase 3	Trimethoprim Sulfamethoxazole;placebo
50	Different Modes of Temperature Measurement in the Emergency Department	Withdrawn	NCT01801020	Phase 3

Search NIH Clinical Center for Pyelonephritis

Cochrane evidence based reviews: pyelonephritis

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Genetic Tests for Pyelonephritis

Genetic tests related to Pyelonephritis:

#	Genetic test	Affiliating Genes
1	Pyelonephritis ²⁹

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Anatomical Context for Pyelonephritis

MalaCards organs/tissues related to Pyelonephritis:

⁴¹

Kidney, Testes, Liver, Prostate, Neutrophil, Spinal Cord, Bone

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Publications for Pyelonephritis

Articles related to Pyelonephritis:

(show top 50) (show all 1840)

#	Title	Authors	Year
1	Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )	Connolly L.E....Miller L.G.	2018
2	Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )	Kakinoki H....Noguchi M.	2018
3	Laparoscopic Heminephrectomy of Chronically Obstructed Horseshoe Kidney Moiety with Staghorn Calculus, Massive Pyonephrosis, and Xanthogranulomatous Pyelonephritis. ( 29662958 )	Fernandez A....Stoller M.L.	2018
4	Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )	Lair M....Vivier P.H.	2018
5	Acute Pyelonephritis in Adults. ( 29565517 )	Spital A.	2018
6	Xanthogranulomatous pyelonephritis complicating crizotinib treatment of an ALK-rearranged non-small-cell lung cancer. ( 29472032 )	Brosseau S....Khalil A.	2018
7	Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )	Vakkilainen S....SaxAcn H.	2018
8	Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma. ( 29522292 )	Ando S.M....Yamauchi F.I.	2018
9	Emphysematous pyelonephritis and cystitis: A case report and literature review. ( 29916283 )	Li S....Wang C.	2018
10	Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005-2015). ( 29197113 )	Bouillon J....Lemetayer J.	2018
11	Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )	Kim Y....Pai H.	2018
12	Acute Pyelonephritis in Adults. ( 29298155 )	Johnson J.R....Russo T.A.	2018
13	Delayed diagnosis of xanthogranulomatous pyelonephritis in a quadriplegic patient with uncontrolled cutaneous fistula: A case report. ( 29480882 )	Yang J.H....Lee N.H.	2018
14	D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )	Lee J.W....Shin J.I.	2018
15	Xanthogranulomatous Pyelonephritis. ( 29514028 )	Marinacci L.X....Rosales I.	2018
16	Pyeloduodenal fistula complicating xanthogranulomatous pyelonephritis. ( 29785659 )	Laberge M....Sreeharsha B.	2018
17	Useful Predictive Factors for Bacteremia among Outpatients with Pyelonephritis. ( 29321419 )	Nakamura N....Naito T.	2018
18	Xanthogranulomatous pyelonephritis: A case report. ( 29888197 )	Morales C....Morales I.	2018
19	Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )	Pompilio A....Di Bonaventura G.	2018
20	Re. &quot;Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study&quot;. ( 29778699 )	Pohl H.G.	2018
21	Emphysematous pyelonephritis. ( 29445494 )	Koratala A....Zeng X.	2018
22	Nephron-sparing management of Xanthogranulomatous pyelonephritis presenting as spontaneous renal hemorrhage: a case report and literature review. ( 29866085 )	Ballentine W.K....Mirzazadeh M.	2018
23	Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study. ( 29588142 )	Bosakova A....Hladik M.	2018
24	Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )	Karakonstantis S....Kalemaki D.	2018
25	Focal Xanthogranulomatous Pyelonephritis with Pulmonary Lesions on the Background of Type Two Diabetes Mellitus. ( 29666742 )	Enshaei A....Bahmani N.	2018
26	Characterization of the Macrophage Infiltrate in a Case of Xanthogranulomatous Pyelonephritis. ( 29770220 )	Zarif J.C....Gorin M.A.	2018
27	The clinical impact of bacteremia on outcomes in elderly patients with pyelonephritis or urinary sepsis: A prospective multicenter study. ( 29364923 )	Artero A....de la Fuente J.	2018
28	Acute Pyelonephritis in Adults. ( 29562155 )	Johnson J.R....Russo T.A.	2018
29	Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )	Rudrabhatla P....Kadhiravan T.	2018
30	Acute Pyelonephritis in Adults. ( 29539281 )		2018
31	The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )	Suh J.W....Yoon Y.K.	2018
32	Multiple gas emboli complicating an emphysematous pyelonephritis. ( 29942752 )	Razazi K....Mekontso Dessap A.	2018
33	Pyelonephritis in persons after age 50 as a clinical marker of urogenital cancer. ( 29654872 )	SA...rensen H.T.	2018
34	Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )	Assimakopoulos S.F....Marangos M.	2018
35	Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )	JansAYker F....Knudsen J.D.	2018
36	Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )	Yeom J.S....Youn H.S.	2018
37	Characterization of subclinical bacteriuria, bacterial cystitis, and pyelonephritis in dogs with chronic kidney disease. ( 29701531 )	Foster J.D....Cole S.	2018
38	Xanthogranulomatous Pyelonephritis: A Complicated Febrile Urinary Tract Infection Detected by Point-of-Care Ultrasound in the Emergency Department. ( 29753570 )	Gibbons R....Costantino T.	2018
39	Colonization of preservation solution in kidney transplantation: Clinical impact and risk of secondary acute graft pyelonephritis. ( 29395835 )	Encatassamy F....BruyA"re F.	2018
40	Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )	Aoyagi J....Yamagata T.	2018
41	Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )		2018
42	Acute infectious aortitis presenting as pyelonephritis. ( 29903668 )	Rimac G....Lafleur A.	2018
43	Unusual presentation of emphysematous pyelonephritis with extension to the scrotum and leg. ( 29709389 )	PiA+A^n Solis E.O....Gil Garcia J.F.	2018
44	A rare case of renal vein thrombosis secondary to<i>Klebsiella pneumoniae</i>pyelonephritis. ( 29416285 )	Lurz K.L....Schanne F.J.	2018
45	Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. ( 29854478 )	Kousoulas L....Utzolino S.	2018
46	Xanthogranulomatous pyelonephritis: a case with rare adhesion to pancreas. ( 29177841 )	Devrim T....TuA9lu D.	2017
47	C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli. ( 29263309 )	Li K....Zhou W.	2017
48	Neuroinvasive Infection from O117:K52:H-<i>Escherichia coli</i>following Acute Pyelonephritis. ( 29318066 )	Cromlin H....Hantson P.	2017
49	Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )	Fukami H....Nagasawa T.	2017
50	Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )	Claessens Y.E....Chenevier-Gobeaux C.	2017

Sources

Genes for Pyelonephritis

Genes related to Pyelonephritis (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TLR4	Toll Like Receptor 4	Protein Coding	26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11260138 11801667
2	CRP	C-Reactive Protein	Protein Coding	24.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	23.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	22.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL6	Interleukin 6	Protein Coding	22.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	NAGLU	N-Acetyl-Alpha-Glucosaminidase	Protein Coding	22.8	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19367005 2371096 9064498 (more) 8036046 2063674
7	ALB	Albumin	Protein Coding	22.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	21.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	UMOD	Uromodulin	Protein Coding	21.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	15816991 15989109
10	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL1B	Interleukin 1 Beta	Protein Coding	20.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	20.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	PGF	Placental Growth Factor	Protein Coding	20.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	ACE	Angiotensin I Converting Enzyme	Protein Coding	20.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	IL10	Interleukin 10	Protein Coding	20.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Pyelonephritis

Sources

Expression for Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Sources

Pathways for Pyelonephritis

Pathways related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.01	CCL2 CRP CXCL8 CXCR1 CXCR2 IL10
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.83	CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
3	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.68	CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.49	CCL2 CXCL8 IL10 IL1B IL6 PGF
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.36	CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.28	CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
7	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.99	ACE CCL2 CXCL8 IL10 IL1B IL6
8	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.86	CXCL8 IL10 IL1B IL6 TNF
9	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.82	CCL2 CXCL8 IL1B IL6 TLR4 TNF
10	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.77	CXCL8 IL1B IL6 TLR4 TNF
11	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.71	IL1B IL6 PGF TLR4 TNF
12	Regulation of IFNA signaling ⁶⁶ Show member pathways Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Jak-STAT signaling pathway ³⁷	12.66	CXCL8 IL10 IL1B IL6 TNF
13	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.62	CCL2 IL10 IL1B IL6 TNF
14	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.55	CXCL8 IL6 TLR4 TNF
15	NF-kappaB Signaling ⁴	12.54	CCL2 IL10 IL1B TNF
16	Th17 cell differentiation ³⁷ Show member pathways Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.48	IL10 IL1B IL6 TLR4 TNF
17	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.43	IL10 IL1B IL6 TNF
18	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.37	CCL2 CXCL8 IL1B IL6 TNF
19	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.33	ALB CCL2 CRP IL1B IL6 TNF
20	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 family signaling ⁶⁶ Interleukin-6 signaling ⁶⁶ Th17 Differentiation Pathway ⁶⁵	12.3	IL10 IL1B IL6 TLR4 TNF
21	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.3	CXCL8 IL1B IL6 TLR4 TNF
22	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.28	CXCL8 IL6 TLR4 TNF
23	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.28	IL10 IL1B TLR4 TNF
24	Tuberculosis ³⁷	12.26	IL10 IL1B IL6 TLR4 TNF
25	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.24	CXCL8 IL1B IL6 TNF
26	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.23	IL10 IL1B IL6 TNF
27	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.21	CXCL8 IL1B IL6 TLR4 TNF
28	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.2	CXCL8 IL10 IL1B IL6 TNF
29	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.11	CCL2 CXCL8 IL10 IL1B IL6 PGF
30	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁵ Show member pathways Chemokine receptors bind chemokines ⁶⁶	12.03	CCL2 CXCL8 CXCR1 CXCR2
31	TNF signaling pathway ³⁷	12	CCL2 IL1B IL6 TNF
32	Spinal Cord Injury ¹	11.99	CCL2 CXCL8 IL1B IL6 TLR4 TNF
33	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.97	IL10 IL6 TNF
34	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.95	CCL2 CXCL8 IL1B IL6 TNF
35	Interleukin-4 and 13 signaling ⁶⁶	11.94	CCL2 CXCL8 IL10 IL1B IL6 TNF
36	Senescence and Autophagy in Cancer ¹	11.93	CXCL8 IL1B IL6
37	NF-kappa B signaling pathway ³⁷	11.93	CXCL8 IL1B TLR4 TNF
38	Hematopoietic cell lineage ³⁷	11.88	IL1B IL6 TNF
39	Salmonella infection (KEGG) ³⁷	11.88	CXCL8 IL1B IL6 TLR4
40	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.86	CXCL8 IL6 TLR4
41	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.8	IL10 IL1B TNF
42	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.8	IL10 IL1B IL6 TNF
43	Amoebiasis ³⁷	11.78	CXCL8 IL10 IL1B IL6 TLR4 TNF
44	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.72	CXCL8 IL1B IL6 TNF
45	Rheumatoid arthritis ³⁷	11.69	CCL2 CXCL8 IL1B IL6 TLR4 TNF
46	Lung fibrosis ¹	11.67	CCL2 CXCL8 IL1B IL6 TNF
47	Legionellosis ³⁷	11.6	CXCL8 IL1B IL6 TLR4 TNF
48	Hepatitis C and Hepatocellular Carcinoma ¹	11.58	CXCL8 CXCR1 IL6
49	MSP-RON Signaling ⁶⁴	11.57	CCL2 IL1B TLR4 TNF
50	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	IL1B IL6 TNF

Sources

GO Terms for Pyelonephritis

Cellular components related to Pyelonephritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	ACE ALB CCL2 CRP CXCL8 IL10
2	extracellular region	GO:0005576	9.36	ACE ALB CCL2 CRP CXCL8 IL10

Biological processes related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to lipopolysaccharide	GO:0032496	9.96	CXCL8 IL10 IL1B TLR4
2	chemotaxis	GO:0006935	9.92	CCL2 CXCL8 CXCR1 CXCR2
3	positive regulation of angiogenesis	GO:0045766	9.9	CXCL8 CXCR2 IL1B PGF
4	activation of MAPK activity	GO:0000187	9.89	IL1B TLR4 TNF
5	defense response to Gram-positive bacterium	GO:0050830	9.88	CRP IL6 TNF
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.88	IL1B IL6 TLR4 TNF
7	immune response	GO:0006955	9.87	CCL2 CXCL8 IL10 IL1B IL6 TLR4
8	cellular response to organic cyclic compound	GO:0071407	9.86	CCL2 IL1B TNF
9	positive regulation of JNK cascade	GO:0046330	9.85	IL1B TLR4 TNF
10	cytokine-mediated signaling pathway	GO:0019221	9.85	CCL2 CXCL8 IL10 IL1B IL6 TNF
11	response to glucocorticoid	GO:0051384	9.84	IL10 IL6 TNF
12	positive regulation of DNA binding transcription factor activity	GO:0051091	9.84	IL10 IL1B IL6 TNF
13	humoral immune response	GO:0006959	9.83	CCL2 IL6 TNF
14	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.82	IL1B TLR4 TNF
15	protein kinase B signaling	GO:0043491	9.81	CCL2 IL1B TNF
16	chemokine-mediated signaling pathway	GO:0070098	9.8	CCL2 CXCL8 CXCR1 CXCR2
17	positive regulation of interferon-gamma production	GO:0032729	9.79	IL1B TLR4 TNF
18	receptor internalization	GO:0031623	9.79	CXCL8 CXCR1 CXCR2
19	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.78	IL1B TLR4 TNF
20	neutrophil chemotaxis	GO:0030593	9.78	CCL2 CXCL8 CXCR2 IL1B
21	positive regulation of interleukin-8 production	GO:0032757	9.73	IL1B TLR4 TNF
22	positive regulation of interleukin-6 production	GO:0032755	9.73	IL1B IL6 TLR4 TNF
23	embryonic digestive tract development	GO:0048566	9.72	CXCL8 TNF
24	dendritic cell chemotaxis	GO:0002407	9.72	CXCR1 CXCR2
25	negative regulation of lipid catabolic process	GO:0050995	9.72	IL1B TNF
26	negative regulation of interleukin-6 production	GO:0032715	9.72	IL10 TLR4 TNF
27	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.71	IL1B TNF
28	positive regulation of macrophage activation	GO:0043032	9.71	IL10 TLR4
29	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.71	CCL2 TLR4
30	negative regulation of growth of symbiont in host	GO:0044130	9.71	IL10 TNF
31	induction of positive chemotaxis	GO:0050930	9.7	CXCL8 PGF
32	response to molecule of bacterial origin	GO:0002237	9.7	CXCL8 IL10
33	PERK-mediated unfolded protein response	GO:0036499	9.7	CCL2 CXCL8
34	positive regulation of leukocyte chemotaxis	GO:0002690	9.7	CXCL8 CXCR2 IL6
35	regulation of signaling receptor activity	GO:0010469	9.7	CCL2 CXCL8 IL10 IL1B IL6 PGF
36	neutrophil activation	GO:0042119	9.69	CXCL8 CXCR2
37	neutrophil mediated immunity	GO:0002446	9.69	ACE IL6
38	positive regulation of chemokine production	GO:0032722	9.69	IL6 TLR4 TNF
39	positive regulation of chemokine biosynthetic process	GO:0045080	9.68	IL1B TNF
40	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.68	TLR4 TNF
41	endothelial cell apoptotic process	GO:0072577	9.68	IL10 TNF
42	positive regulation of MHC class II biosynthetic process	GO:0045348	9.67	IL10 TLR4
43	regulation of establishment of endothelial barrier	GO:1903140	9.67	IL1B TNF
44	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.66	IL10 TNF
45	positive regulation of fever generation	GO:0031622	9.65	IL1B TNF
46	sequestering of triglyceride	GO:0030730	9.63	IL1B TNF
47	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.63	IL10 IL1B TNF
48	receptor biosynthetic process	GO:0032800	9.59	IL10 TNF
49	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.58	IL1B TNF
50	negative regulation of lipid storage	GO:0010888	9.58	CRP IL6 TNF

Molecular functions related to Pyelonephritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	C-X-C chemokine receptor activity	GO:0016494	9.26	CXCR1 CXCR2
2	interleukin-8 binding	GO:0019959	9.16	CXCR1 CXCR2
3	cytokine activity	GO:0005125	9.1	CCL2 CXCL8 IL10 IL1B IL6 TNF
4	interleukin-8 receptor activity	GO:0004918	8.96	CXCR1 CXCR2

Sources

Sources for Pyelonephritis

¹ BioSystems

² BitterDB

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⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia