MCID: PYL005
MIFTS: 56

Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Pyelonephritis

Summaries for Pyelonephritis

MalaCards based summary : Pyelonephritis is related to pyelitis and acute cystitis. An important gene associated with Pyelonephritis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most... more...

Related Diseases for Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 472)
# Related Disease Score Top Affiliating Genes
1 pyelitis 32.8 CRP CXCR1 TLR4
2 acute cystitis 31.8 ALB CCL2 CRP CXCL8 IL6
3 hydronephrosis 30.7 ALB CCL2 NAGLU
4 pyuria 30.7 ALB CRP CXCL8
5 fasciitis 30.6 CXCL8 IL6 TNF
6 septic arthritis 30.3 CRP CXCL8 TLR4
7 infective endocarditis 30.1 CRP IL6 TNF
8 vaginitis 30.0 CXCL8 IL1B IL6
9 endometriosis 30.0 CCL2 CXCL8 IL6
10 spondylitis 30.0 CRP IL6 TNF
11 glomerulonephritis 30.0 ALB CCL2 IL1B
12 bacteriuria 29.9 CXCL8 CXCR1 CXCR2 IL6 TLR4
13 osteomyelitis 29.9 CXCL8 IL1B IL6 TNF
14 bronchitis 29.9 ALB CXCL8 TNF
15 haemophilus influenzae 29.8 CXCL8 IL1B TNF
16 acute pyelonephritis 29.8 ALB CRP CXCL8 CXCR1 CXCR2 IL10
17 salmonellosis 29.7 ALB IL1B TLR4
18 cerebral palsy 29.7 IL1B IL6 TNF
19 acute kidney tubular necrosis 29.6 ALB NAGLU UMOD
20 cholangitis 29.6 ALB CRP IL6 TNF
21 posterior urethral valves 29.4 ACE IL6 TNF
22 interstitial nephritis 29.4 ACE ALB CRP UMOD
23 cystitis 29.4 CRP CXCL8 IL6 TLR4 TNF UMOD
24 placenta disease 29.4 CXCL8 IL1B IL6 PGF
25 eclampsia 29.3 ALB PGF TNF
26 autosomal dominant polycystic kidney disease 29.3 ACE ALB CCL2
27 myeloma, multiple 29.2 ALB CRP CXCL8 IL6 TNF
28 urinary tract obstruction 29.1 ALB CCL2 NAGLU UMOD
29 chronic kidney failure 28.6 ACE ALB CRP IL6 UMOD
30 melioidosis 28.6 IL10 IL6 TLR4 TNF
31 prostatitis 28.6 CXCL8 IL10 IL1B IL6 TNF
32 diabetes mellitus 28.4 ACE ALB CRP IL1B IL6 TNF
33 kidney disease 28.2 ACE ALB CCL2 CRP NAGLU UMOD
34 adult respiratory distress syndrome 27.9 ACE CXCL8 IL10 IL6 TNF
35 end stage renal failure 27.8 ACE ALB CRP IL6 TNF UMOD
36 brucellosis 27.8 CRP CXCL8 IL10 IL6 TLR4 TNF
37 endocarditis 27.8 ALB CRP CXCL8 IL10 IL6 TNF
38 arthritis 27.7 CCL2 CXCL8 IL10 IL1B IL6 TNF
39 heart disease 27.7 ACE ALB CRP IL1B IL6 TNF
40 colitis 27.7 CXCL8 IL10 IL1B IL6 TLR4 TNF
41 arteriosclerosis 27.7 ACE CCL2 CRP IL10 IL6
42 kawasaki disease 27.6 ALB CCL2 CRP IL10 IL6 TNF
43 crohn's disease 27.5 CRP IL10 IL1B IL6 TLR4 TNF
44 systemic lupus erythematosus 27.4 ALB CCL2 CRP IL10 IL6 TNF
45 appendicitis 27.3 ALB CRP CXCL8 IL10 IL1B IL6
46 gastroenteritis 27.0 ALB CRP CXCL8 IL10 IL1B IL6
47 pneumonia 27.0 CCL2 CRP CXCL8 IL10 IL1B IL6
48 rheumatoid arthritis 26.7 CCL2 CRP CXCL8 IL10 IL1B IL6
49 xanthogranulomatous pyelonephritis 12.2
50 chronic pyelonephritis 12.2

Comorbidity relations with Pyelonephritis via Phenotypic Disease Network (PDN): (show all 22)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, X-Linked Recessive, with Renal Failure Osteoporosis
Paralytic Ileus Protein-Energy Malnutrition
Schizophreniform Disorder Ureterolithiasis

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to Pyelonephritis

Symptoms & Phenotypes for Pyelonephritis

GenomeRNAi Phenotypes related to Pyelonephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE CXCL8 IL10 IL1B TNF UMOD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ACE CXCL8 IL10 IL1B TNF UMOD

MGI Mouse Phenotypes related to Pyelonephritis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.22 ACE IL10 IL1B CCL2 CRP CXCR1
2 cardiovascular system MP:0005385 10.19 ACE IL10 IL1B CRP IL6 CXCR2
3 growth/size/body region MP:0005378 10.18 CXCR2 IL6 IL10 ACE IL1B TLR4
4 homeostasis/metabolism MP:0005376 10.17 IL10 ACE ALB IL1B CRP IL6
5 hematopoietic system MP:0005397 10.11 CXCR2 ACE IL10 IL1B CXCR1 IL6
6 adipose tissue MP:0005375 9.99 IL6 ACE TLR4 TNF PGF UMOD
7 liver/biliary system MP:0005370 9.92 ACE IL10 ALB IL6 CXCR2 NAGLU
8 integument MP:0010771 9.91 IL10 IL1B IL6 TLR4 NAGLU TNF
9 neoplasm MP:0002006 9.91 ACE IL10 ALB IL1B IL6 CXCR2
10 renal/urinary system MP:0005367 9.7 ACE ALB IL6 CXCR2 NAGLU UMOD
11 skeleton MP:0005390 9.56 CXCR2 IL6 IL10 IL1B TLR4 NAGLU
12 vision/eye MP:0005391 9.17 CXCR2 IL10 IL6 TLR4 NAGLU TNF

Drugs & Therapeutics for Pyelonephritis

Drugs for Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved, Investigational Phase 4,Phase 1 79350-37-1 54362 5362065
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
6
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 67-20-9 5353830
7
Sulfamethoxazole Approved Phase 4,Phase 3,Not Applicable 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Not Applicable 738-70-5 5578
9
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
10
Ibuprofen Approved Phase 4 15687-27-1 3672
11
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
12
Fosfomycin Approved Phase 4,Phase 2,Phase 3 23155-02-4 446987
13
Cilastatin Approved, Investigational Phase 4,Phase 2 82009-34-5 5280454 6435415
14
Imipenem Approved Phase 4,Phase 2 74431-23-5, 64221-86-9 104838
15
Cephalexin Approved, Investigational, Vet_approved Phase 4,Not Applicable 15686-71-2 27447
16
Azithromycin Approved Phase 4 83905-01-5 55185 447043
17
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
18
Metronidazole Approved Phase 4 443-48-1 4173
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
21
Cefotaxime Approved Phase 4,Not Applicable 63527-52-6 456256 5742673
22
Cefoxitin Approved Phase 4,Not Applicable 35607-66-0 441199
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-30-3 6037
24
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 58-05-9 143 6006
25 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Antitubercular Agents Phase 4,Phase 3,Not Applicable
29 Fluoroquinolones Phase 4,Phase 2
30 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
31 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
32 Analgesics Phase 4,Phase 1,Phase 2
33 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
34 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2
36 Antirheumatic Agents Phase 4,Phase 1,Phase 2
37 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
38 HIV Protease Inhibitors Phase 4,Phase 2
39
protease inhibitors Phase 4,Phase 2
40 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
41 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
42 Renal Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Antimalarials Phase 4,Phase 3,Not Applicable
44 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
45 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
46 Folic Acid Antagonists Phase 4,Phase 3,Not Applicable
47 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Not Applicable
48 Vitamin B Complex Phase 4,Phase 3,Not Applicable
49 Lactams Phase 4
50 Amdinocillin Pivoxil Phase 4

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
2 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
5 Pharmacokinetics of Ciprofloxacin in Pediatric Patients Completed NCT02598362 Phase 4 ciprofloxacin
6 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
7 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
8 Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aerugi Completed NCT00481689 Phase 4 Cipro XR (Ciprofloxacin, BAYQ3939)
9 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
10 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
11 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
12 Treating Pyelonephritis an Urosepsis With Pivmecillinam Recruiting NCT03282006 Phase 4 pivmecillinam
13 Management of Sub-Clinical Bacteriuria in Pregnancy Recruiting NCT03275623 Phase 4 Antibiotic
14 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
15 Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial Recruiting NCT03151603 Phase 4 Arctuvan;Fosfomycin;Placebo to Arctuvan;Placebo to Fosfomycin
16 The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria Recruiting NCT01871753 Phase 4
17 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
18 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
19 Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy. Not yet recruiting NCT03228108 Phase 4 Ciprofloxacin;Trimethoprim/Sulfamethoxazole;Fosfomycin;Pivmecillinam/augmentin
20 Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations Suspended NCT01685658 Phase 4 Intravenous ketoprofen;Intravenous paracetamol
21 Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin Terminated NCT00239161 Phase 4 Levofloxacin
22 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
23 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
24 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
25 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00210990 Phase 3 doripenem
26 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00229021 Phase 3 doripenum
27 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis Completed NCT01345929 Phase 3 CXA-201;Levofloxacin
28 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
29 Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014) Completed NCT02728089 Phase 3 MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g)
30 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
31 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
32 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
33 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
34 CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria Completed NCT03477422 Phase 3 CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
35 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
36 A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED) Completed NCT00379964 Phase 3 caspofungin acetate
37 A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048) Completed NCT00379951 Phase 3 ertapenem sodium
38 A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections Completed NCT00258089 Phase 3 Levofloxacin
39 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3 Bisphosphonate;Placebo
40 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
41 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
42 Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults Completed NCT02168946 Phase 3 Vabomere;Best Available Therapy
43 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
44 Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections Not yet recruiting NCT03543436 Phase 3 Temocillin;meropenem or imipenem
45 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
46 A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections Terminated NCT01110408 Phase 3 Doripenem;Doripenem placebo;Cefepime;Cefepime placebo;Amoxicillin/clavulanate potassium
47 An Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections Terminated NCT02302092 Phase 3 Flomoxef;Cefepime
48 Efficacy of Antimicrobial Prophylaxis for Shock Wave Lithotripsy (SWL) on Reducing Urinary Tract Infection (UTI) Terminated NCT01873690 Phase 3 Ciprofloxacin;Placebo
49 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3 Trimethoprim Sulfamethoxazole;placebo
50 Different Modes of Temperature Measurement in the Emergency Department Withdrawn NCT01801020 Phase 3

Search NIH Clinical Center for Pyelonephritis

Cochrane evidence based reviews: pyelonephritis

Genetic Tests for Pyelonephritis

Genetic tests related to Pyelonephritis:

# Genetic test Affiliating Genes
1 Pyelonephritis 29

Anatomical Context for Pyelonephritis

MalaCards organs/tissues related to Pyelonephritis:

41
Kidney, Testes, Liver, Prostate, Neutrophil, Spinal Cord, Bone

Publications for Pyelonephritis

Articles related to Pyelonephritis:

(show top 50) (show all 1840)
# Title Authors Year
1
Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )
2018
2
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
3
Laparoscopic Heminephrectomy of Chronically Obstructed Horseshoe Kidney Moiety with Staghorn Calculus, Massive Pyonephrosis, and Xanthogranulomatous Pyelonephritis. ( 29662958 )
2018
4
Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )
2018
5
Acute Pyelonephritis in Adults. ( 29565517 )
2018
6
Xanthogranulomatous pyelonephritis complicating crizotinib treatment of an ALK-rearranged non-small-cell lung cancer. ( 29472032 )
2018
7
Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )
2018
8
Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma. ( 29522292 )
2018
9
Emphysematous pyelonephritis and cystitis: A case report and literature review. ( 29916283 )
2018
10
Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005-2015). ( 29197113 )
2018
11
Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )
2018
12
Acute Pyelonephritis in Adults. ( 29298155 )
2018
13
Delayed diagnosis of xanthogranulomatous pyelonephritis in a quadriplegic patient with uncontrolled cutaneous fistula: A case report. ( 29480882 )
2018
14
D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )
2018
15
Xanthogranulomatous Pyelonephritis. ( 29514028 )
2018
16
Pyeloduodenal fistula complicating xanthogranulomatous pyelonephritis. ( 29785659 )
2018
17
Useful Predictive Factors for Bacteremia among Outpatients with Pyelonephritis. ( 29321419 )
2018
18
Xanthogranulomatous pyelonephritis: A case report. ( 29888197 )
2018
19
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )
2018
20
Re. "Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study". ( 29778699 )
2018
21
Emphysematous pyelonephritis. ( 29445494 )
2018
22
Nephron-sparing management of Xanthogranulomatous pyelonephritis presenting as spontaneous renal hemorrhage: a case report and literature review. ( 29866085 )
2018
23
Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study. ( 29588142 )
2018
24
Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )
2018
25
Focal Xanthogranulomatous Pyelonephritis with Pulmonary Lesions on the Background of Type Two Diabetes Mellitus. ( 29666742 )
2018
26
Characterization of the Macrophage Infiltrate in a Case of Xanthogranulomatous Pyelonephritis. ( 29770220 )
2018
27
The clinical impact of bacteremia on outcomes in elderly patients with pyelonephritis or urinary sepsis: A prospective multicenter study. ( 29364923 )
2018
28
Acute Pyelonephritis in Adults. ( 29562155 )
2018
29
Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )
2018
30
Acute Pyelonephritis in Adults. ( 29539281 )
2018
31
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )
2018
32
Multiple gas emboli complicating an emphysematous pyelonephritis. ( 29942752 )
2018
33
Pyelonephritis in persons after age 50 as a clinical marker of urogenital cancer. ( 29654872 )
2018
34
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
35
Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )
2018
36
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )
2018
37
Characterization of subclinical bacteriuria, bacterial cystitis, and pyelonephritis in dogs with chronic kidney disease. ( 29701531 )
2018
38
Xanthogranulomatous Pyelonephritis: A Complicated Febrile Urinary Tract Infection Detected by Point-of-Care Ultrasound in the Emergency Department. ( 29753570 )
2018
39
Colonization of preservation solution in kidney transplantation: Clinical impact and risk of secondary acute graft pyelonephritis. ( 29395835 )
2018
40
Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )
2018
41
Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )
2018
42
Acute infectious aortitis presenting as pyelonephritis. ( 29903668 )
2018
43
Unusual presentation of emphysematous pyelonephritis with extension to the scrotum and leg. ( 29709389 )
2018
44
A rare case of renal vein thrombosis secondary to<i>Klebsiella pneumoniae</i>pyelonephritis. ( 29416285 )
2018
45
Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. ( 29854478 )
2018
46
Xanthogranulomatous pyelonephritis: a case with rare adhesion to pancreas. ( 29177841 )
2017
47
C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli. ( 29263309 )
2017
48
Neuroinvasive Infection from O117:K52:H-<i>Escherichia coli</i>following Acute Pyelonephritis. ( 29318066 )
2017
49
Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )
2017
50
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017

Variations for Pyelonephritis

Expression for Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for Pyelonephritis

Pathways related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CRP CXCL8 CXCR1 CXCR2 IL10
2
Show member pathways
13.83 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
3
Show member pathways
13.68 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
4
Show member pathways
13.49 CCL2 CXCL8 IL10 IL1B IL6 PGF
5
Show member pathways
13.36 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
6
Show member pathways
13.28 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
7
Show member pathways
12.99 ACE CCL2 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.86 CXCL8 IL10 IL1B IL6 TNF
9
Show member pathways
12.82 CCL2 CXCL8 IL1B IL6 TLR4 TNF
10
Show member pathways
12.77 CXCL8 IL1B IL6 TLR4 TNF
11
Show member pathways
12.71 IL1B IL6 PGF TLR4 TNF
12
Show member pathways
12.66 CXCL8 IL10 IL1B IL6 TNF
13
Show member pathways
12.62 CCL2 IL10 IL1B IL6 TNF
14
Show member pathways
12.55 CXCL8 IL6 TLR4 TNF
15 12.54 CCL2 IL10 IL1B TNF
16
Show member pathways
12.48 IL10 IL1B IL6 TLR4 TNF
17
Show member pathways
12.43 IL10 IL1B IL6 TNF
18
Show member pathways
12.37 CCL2 CXCL8 IL1B IL6 TNF
19
Show member pathways
12.33 ALB CCL2 CRP IL1B IL6 TNF
20
Show member pathways
12.3 IL10 IL1B IL6 TLR4 TNF
21
Show member pathways
12.3 CXCL8 IL1B IL6 TLR4 TNF
22
Show member pathways
12.28 CXCL8 IL6 TLR4 TNF
23
Show member pathways
12.28 IL10 IL1B TLR4 TNF
24 12.26 IL10 IL1B IL6 TLR4 TNF
25
Show member pathways
12.24 CXCL8 IL1B IL6 TNF
26
Show member pathways
12.23 IL10 IL1B IL6 TNF
27
Show member pathways
12.21 CXCL8 IL1B IL6 TLR4 TNF
28 12.2 CXCL8 IL10 IL1B IL6 TNF
29
Show member pathways
12.11 CCL2 CXCL8 IL10 IL1B IL6 PGF
30
Show member pathways
12.03 CCL2 CXCL8 CXCR1 CXCR2
31 12 CCL2 IL1B IL6 TNF
32 11.99 CCL2 CXCL8 IL1B IL6 TLR4 TNF
33 11.97 IL10 IL6 TNF
34 11.95 CCL2 CXCL8 IL1B IL6 TNF
35 11.94 CCL2 CXCL8 IL10 IL1B IL6 TNF
36 11.93 CXCL8 IL1B IL6
37 11.93 CXCL8 IL1B TLR4 TNF
38 11.88 IL1B IL6 TNF
39 11.88 CXCL8 IL1B IL6 TLR4
40
Show member pathways
11.86 CXCL8 IL6 TLR4
41 11.8 IL10 IL1B TNF
42 11.8 IL10 IL1B IL6 TNF
43 11.78 CXCL8 IL10 IL1B IL6 TLR4 TNF
44
Show member pathways
11.72 CXCL8 IL1B IL6 TNF
45 11.69 CCL2 CXCL8 IL1B IL6 TLR4 TNF
46 11.67 CCL2 CXCL8 IL1B IL6 TNF
47 11.6 CXCL8 IL1B IL6 TLR4 TNF
48 11.58 CXCL8 CXCR1 IL6
49 11.57 CCL2 IL1B TLR4 TNF
50 11.52 IL1B IL6 TNF

GO Terms for Pyelonephritis

Cellular components related to Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ALB CCL2 CRP CXCL8 IL10
2 extracellular region GO:0005576 9.36 ACE ALB CCL2 CRP CXCL8 IL10

Biological processes related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.96 CXCL8 IL10 IL1B TLR4
2 chemotaxis GO:0006935 9.92 CCL2 CXCL8 CXCR1 CXCR2
3 positive regulation of angiogenesis GO:0045766 9.9 CXCL8 CXCR2 IL1B PGF
4 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR4 TNF
7 immune response GO:0006955 9.87 CCL2 CXCL8 IL10 IL1B IL6 TLR4
8 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
9 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TNF
10 cytokine-mediated signaling pathway GO:0019221 9.85 CCL2 CXCL8 IL10 IL1B IL6 TNF
11 response to glucocorticoid GO:0051384 9.84 IL10 IL6 TNF
12 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL10 IL1B IL6 TNF
13 humoral immune response GO:0006959 9.83 CCL2 IL6 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 IL1B TLR4 TNF
15 protein kinase B signaling GO:0043491 9.81 CCL2 IL1B TNF
16 chemokine-mediated signaling pathway GO:0070098 9.8 CCL2 CXCL8 CXCR1 CXCR2
17 positive regulation of interferon-gamma production GO:0032729 9.79 IL1B TLR4 TNF
18 receptor internalization GO:0031623 9.79 CXCL8 CXCR1 CXCR2
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 IL1B TLR4 TNF
20 neutrophil chemotaxis GO:0030593 9.78 CCL2 CXCL8 CXCR2 IL1B
21 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR4 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 TLR4 TNF
23 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
24 dendritic cell chemotaxis GO:0002407 9.72 CXCR1 CXCR2
25 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
26 negative regulation of interleukin-6 production GO:0032715 9.72 IL10 TLR4 TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
28 positive regulation of macrophage activation GO:0043032 9.71 IL10 TLR4
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR4
30 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 TNF
31 induction of positive chemotaxis GO:0050930 9.7 CXCL8 PGF
32 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 IL10
33 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
34 positive regulation of leukocyte chemotaxis GO:0002690 9.7 CXCL8 CXCR2 IL6
35 regulation of signaling receptor activity GO:0010469 9.7 CCL2 CXCL8 IL10 IL1B IL6 PGF
36 neutrophil activation GO:0042119 9.69 CXCL8 CXCR2
37 neutrophil mediated immunity GO:0002446 9.69 ACE IL6
38 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR4 TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
40 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
41 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 TLR4
43 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 IL10 TNF
45 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
46 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
48 receptor biosynthetic process GO:0032800 9.59 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
50 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 TNF

Molecular functions related to Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
2 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 interleukin-8 receptor activity GO:0004918 8.96 CXCR1 CXCR2

Sources for Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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