MCID: PYL005
MIFTS: 56

Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Pyelonephritis

Summaries for Pyelonephritis

MalaCards based summary : Pyelonephritis is related to acute pyelonephritis and pyelitis. An important gene associated with Pyelonephritis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most... more...

Related Diseases for Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)
# Related Disease Score Top Affiliating Genes
1 acute pyelonephritis 32.4 ALB CRP CXCL8 CXCR1 CXCR2 IL10
2 pyelitis 32.1 CRP CXCL8 CXCR1 IL6 TLR4
3 acute cystitis 32.1 ALB CCL2 CRP CXCL8 IL6
4 cystitis 31.6 CCL2 CRP CXCL8 IL6 TLR4 TNF
5 hydronephrosis 30.6 ALB CCL2 NAGLU
6 vesicoureteral reflux 1 30.6 CRP NAGLU UMOD
7 glomerulonephritis 30.4 ALB CCL2 IL1B
8 fasciitis 30.3 CXCL8 IL6 TNF
9 pyuria 30.2 ALB CRP CXCL8
10 bacteriuria 30.2 CCL2 CXCL8 CXCR1 IL6 TLR4 UMOD
11 interstitial nephritis 30.1 ACE ALB CRP UMOD
12 urinary tract obstruction 29.9 ALB CCL2 NAGLU UMOD
13 diabetes mellitus 29.9 ACE ALB CRP IL1B IL6 TNF
14 haemophilus influenzae 29.9 CXCL8 IL1B TNF
15 autosomal dominant polycystic kidney disease 29.8 ACE ALB CCL2
16 acute kidney tubular necrosis 29.8 ALB NAGLU UMOD
17 septic arthritis 29.8 CRP CXCL8 TLR4
18 infective endocarditis 29.7 CRP IL6 TNF
19 spondylitis 29.7 CRP IL6 TNF
20 cerebral palsy 29.6 IL1B IL6 TNF
21 posterior urethral valves 29.6 ACE IL6 TNF
22 bronchitis 29.6 ALB CRP CXCL8 TNF
23 kidney disease 29.6 ACE ALB CCL2 CRP IL6 NAGLU
24 cholangitis 29.6 ALB CRP IL6 TNF
25 chronic kidney failure 29.6 ACE ALB CRP IL6 UMOD
26 endometriosis 29.5 CCL2 CXCL8 IL1B IL6
27 prostatitis 29.5 CXCL8 IL10 IL1B IL6 TNF
28 osteomyelitis 29.5 CXCL8 IL10 IL1B IL6 TNF
29 eclampsia 29.5 ALB PGF TNF
30 adult respiratory distress syndrome 29.5 ACE CXCL8 IL10 IL6 TNF
31 end stage renal failure 29.5 ACE ALB CRP IL6 TNF UMOD
32 myeloma, multiple 29.4 ALB CRP CXCL8 IL6 TNF
33 acute pancreatitis 29.4 CRP CXCL8 IL10 IL6
34 aspergillosis 29.3 IL10 TLR4 TNF
35 crohn's disease 29.3 CRP IL10 TNF
36 iga glomerulonephritis 29.3 ACE ALB CCL2 IL6 NAGLU
37 melioidosis 29.3 IL10 IL6 TLR4 TNF
38 arthritis 29.2 CCL2 CXCL8 IL10 IL1B IL6 TNF
39 endocarditis 29.2 ALB CRP CXCL8 IL10 IL6 TNF
40 colitis 29.1 CXCL8 IL10 IL1B IL6 TLR4 TNF
41 meningitis 29.1 ALB CCL2 CRP CXCL8 IL10 IL1B
42 diabetes mellitus, noninsulin-dependent 29.1 ACE ALB CCL2 CRP IL6 TNF
43 viral infectious disease 29.1 CXCL8 IL10 IL1B IL6 TNF
44 brucellosis 29.0 CRP CXCL8 IL10 IL6 TLR4 TNF
45 appendicitis 29.0 ALB CRP CXCL8 IL10 IL1B IL6
46 pneumonia 28.9 CCL2 CRP CXCL8 IL10 IL1B IL6
47 kawasaki disease 28.9 ALB CCL2 CRP IL10 IL6 TNF
48 arteriosclerosis 28.9 ACE CCL2 CRP IL10 IL6 TLR4
49 rheumatoid arthritis 28.8 CCL2 CRP CXCL8 IL10 IL1B IL6
50 gastroenteritis 28.8 ALB CRP CXCL8 IL10 IL1B IL6

Comorbidity relations with Pyelonephritis via Phenotypic Disease Network (PDN): (show all 22)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, X-Linked Recessive, with Renal Failure Osteoporosis
Paralytic Ileus Protein-Energy Malnutrition
Schizophreniform Disorder Ureterolithiasis

Graphical network of the top 20 diseases related to Pyelonephritis:



Diseases related to Pyelonephritis

Symptoms & Phenotypes for Pyelonephritis

GenomeRNAi Phenotypes related to Pyelonephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE CXCL8 IL10 IL1B TNF UMOD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ACE CXCL8 IL10 IL1B TNF UMOD

MGI Mouse Phenotypes related to Pyelonephritis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.22 ACE CCL2 CRP CXCR1 CXCR2 IL10
2 cardiovascular system MP:0005385 10.19 ACE CRP CXCR2 IL10 IL1B IL6
3 growth/size/body region MP:0005378 10.18 ACE CXCR2 IL10 IL1B IL6 NAGLU
4 homeostasis/metabolism MP:0005376 10.17 ACE ALB CRP CXCR2 IL10 IL1B
5 hematopoietic system MP:0005397 10.11 ACE CXCR1 CXCR2 IL10 IL1B IL6
6 adipose tissue MP:0005375 9.99 ACE IL6 PGF TLR4 TNF UMOD
7 liver/biliary system MP:0005370 9.92 ACE ALB CXCR2 IL10 IL6 NAGLU
8 integument MP:0010771 9.91 IL10 IL1B IL6 NAGLU PGF TLR4
9 neoplasm MP:0002006 9.91 ACE ALB CXCR2 IL10 IL1B IL6
10 renal/urinary system MP:0005367 9.7 ACE ALB CXCR2 IL6 NAGLU TLR4
11 skeleton MP:0005390 9.56 CXCR2 IL10 IL1B IL6 NAGLU TLR4
12 vision/eye MP:0005391 9.17 CXCR2 IL10 IL6 NAGLU PGF TLR4

Drugs & Therapeutics for Pyelonephritis

Drugs for Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Not Applicable 58-05-9 6006 143
2
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Not Applicable 738-70-5 5578
3
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 67-20-9 5353830
4
Sulfamethoxazole Approved Phase 4,Phase 3,Not Applicable 723-46-6 5329
5
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
6
Cephalexin Approved, Investigational, Vet_approved Phase 4,Not Applicable 15686-71-2 27447
7
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
8
Cefixime Approved, Investigational Phase 4,Phase 1 79350-37-1 5362065 54362
9
Ceftriaxone Approved Phase 4,Phase 3 73384-59-5 5479530 5361919
10
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
11
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
12
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
13
Ibuprofen Approved Phase 4 15687-27-1 3672
14
Fosfomycin Approved Phase 4,Phase 2,Phase 3,Phase 1 23155-02-4 446987
15
Cilastatin Approved, Investigational Phase 4,Phase 2 82009-34-5 6435415 5280454
16
Imipenem Approved Phase 4,Phase 3,Phase 2 74431-23-5, 64221-86-9 104838
17
Azithromycin Approved Phase 4 83905-01-5 55185 447043
18
Metronidazole Approved Phase 4 443-48-1 4173
19
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
20
Acetaminophen Approved Phase 4 103-90-2 1983
21
Cefotaxime Approved Phase 4,Not Applicable 63527-52-6 456256 5742673
22
Cefoxitin Approved Phase 4,Not Applicable 35607-66-0 441199
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-30-3 6037
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Antitubercular Agents Phase 4,Phase 3,Not Applicable
28 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 1
29 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2,Not Applicable
30 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
31 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
32 Renal Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Fluoroquinolones Phase 4,Phase 2,Phase 1
34 Vitamin B9 Phase 4,Phase 3,Not Applicable
35 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
36 Folic Acid Antagonists Phase 4,Phase 3,Not Applicable
37 Vitamin B Complex Phase 4,Phase 3,Not Applicable
38 Antimalarials Phase 4,Phase 3,Not Applicable
39 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Not Applicable
40 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
41 Folate Phase 4,Phase 3,Not Applicable
42 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
43 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
44 Analgesics Phase 4,Phase 1,Phase 2
45 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
46 Antirheumatic Agents Phase 4,Phase 1,Phase 2
47 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2
48 cefuroxime axetil Phase 4,Not Applicable
49 Clavulanic Acids Phase 4,Phase 3,Not Applicable
50 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 128)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
2 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
5 Pharmacokinetics of Ciprofloxacin in Pediatric Patients Completed NCT02598362 Phase 4 ciprofloxacin
6 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
7 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
8 Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aeruginosa And Other Common Uropathogens Completed NCT00481689 Phase 4 Cipro XR (Ciprofloxacin, BAYQ3939)
9 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
10 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
11 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
12 Treating Pyelonephritis an Urosepsis With Pivmecillinam Recruiting NCT03282006 Phase 4 pivmecillinam
13 Management of Sub-Clinical Bacteriuria in Pregnancy Recruiting NCT03275623 Phase 4 Antibiotic
14 Antibiotic Prophylaxis Before Shock Wave Lithotripsy Recruiting NCT03692715 Phase 4 Ciprofloxacin;Placebo
15 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
16 Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial Recruiting NCT03151603 Phase 4 Arctuvan;Fosfomycin;Placebo to Arctuvan;Placebo to Fosfomycin
17 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
18 The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria Recruiting NCT01871753 Phase 4
19 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
20 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
21 Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy. Not yet recruiting NCT03228108 Phase 4 Ciprofloxacin;Trimethoprim/Sulfamethoxazole;Fosfomycin;Pivmecillinam/augmentin
22 Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations Suspended NCT01685658 Phase 4 Intravenous ketoprofen;Intravenous paracetamol
23 Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin Terminated NCT00239161 Phase 4 Levofloxacin
24 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
25 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
26 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
27 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00210990 Phase 3 doripenem
28 Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis Completed NCT00229021 Phase 3 doripenum
29 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis Completed NCT01345929 Phase 3 CXA-201;Levofloxacin
30 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
31 Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014) Completed NCT02728089 Phase 3 MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g)
32 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
33 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
34 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
35 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
36 CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria Completed NCT03477422 Phase 3 CSE-1034 (Ceftriaxone + Sulbactam + EDTA);Meropenem
37 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
38 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
39 Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults Completed NCT02168946 Phase 3 Vabomere;Best Available Therapy
40 A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED) Completed NCT00379964 Phase 3 caspofungin acetate
41 A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048) Completed NCT00379951 Phase 3 ertapenem sodium
42 A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections Completed NCT00258089 Phase 3 Levofloxacin
43 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3 Bisphosphonate;Placebo
44 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
45 Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections Recruiting NCT03687255 Phase 3 cefepime/AAI101 combination;Piperacillin/tazobactam
46 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
47 Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Not yet recruiting NCT03788967 Phase 3 Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr);Ertapenem
48 Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Not yet recruiting NCT03630081 Phase 3 FEP-TAZ 4 g;Meropenem;ciprofloxacin 500 mg Optional Oral Switch
49 Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections Not yet recruiting NCT03543436 Phase 3 Temocillin;meropenem or imipenem
50 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten

Search NIH Clinical Center for Pyelonephritis

Cochrane evidence based reviews: pyelonephritis

Genetic Tests for Pyelonephritis

Genetic tests related to Pyelonephritis:

# Genetic test Affiliating Genes
1 Pyelonephritis 29

Anatomical Context for Pyelonephritis

MalaCards organs/tissues related to Pyelonephritis:

41
Kidney, Testes, Neutrophil, Lung, Prostate, Liver, Endothelial

Publications for Pyelonephritis

Articles related to Pyelonephritis:

(show top 50) (show all 2126)
# Title Authors Year
1
Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )
2018
2
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
3
Laparoscopic Heminephrectomy of Chronically Obstructed Horseshoe Kidney Moiety with Staghorn Calculus, Massive Pyonephrosis, and Xanthogranulomatous Pyelonephritis. ( 29662958 )
2018
4
Diffusion tensor imaging in acute pyelonephritis in children. ( 29789888 )
2018
5
Acute Pyelonephritis in Adults. ( 29565517 )
2018
6
Xanthogranulomatous pyelonephritis complicating crizotinib treatment of an ALK-rearranged non-small-cell lung cancer. ( 29472032 )
2018
7
Outcome of children with ESBL-E. coli acute pyelonephritis treated with cephalosporins. ( 29746942 )
2018
8
Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma. ( 29522292 )
2018
9
Emphysematous pyelonephritis and cystitis: A case report and literature review. ( 29916283 )
2018
10
Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005-2015). ( 29197113 )
2018
11
Reply: Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637754 )
2018
12
Acute Pyelonephritis in Adults. ( 29298155 )
2018
13
Delayed diagnosis of xanthogranulomatous pyelonephritis in a quadriplegic patient with uncontrolled cutaneous fistula: A case report. ( 29480882 )
2018
14
D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )
2018
15
Xanthogranulomatous Pyelonephritis. ( 29514028 )
2018
16
Pyeloduodenal fistula complicating xanthogranulomatous pyelonephritis. ( 29785659 )
2018
17
Useful Predictive Factors for Bacteremia among Outpatients with Pyelonephritis. ( 29321419 )
2018
18
Xanthogranulomatous pyelonephritis: A case report. ( 29888197 )
2018
19
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis. ( 29758033 )
2018
20
Re. "Diffusion weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study". ( 29778699 )
2018
21
Emphysematous pyelonephritis. ( 29445494 )
2018
22
Nephron-sparing management of Xanthogranulomatous pyelonephritis presenting as spontaneous renal hemorrhage: a case report and literature review. ( 29866085 )
2018
23
Diffusion-weighted magnetic resonance imaging is more sensitive than dimercaptosuccinic acid scintigraphy in detecting parenchymal lesions in children with acute pyelonephritis: AA prospective study. ( 29588142 )
2018
24
Is Taking Blood Cultures Indicated in Acute Pyelonephritis Patients Who Have Used Antibiotics before Presentation? ( 29637753 )
2018
25
Focal Xanthogranulomatous Pyelonephritis with Pulmonary Lesions on the Background of Type Two Diabetes Mellitus. ( 29666742 )
2018
26
Characterization of the Macrophage Infiltrate in a Case of Xanthogranulomatous Pyelonephritis. ( 29770220 )
2018
27
The clinical impact of bacteremia on outcomes in elderly patients with pyelonephritis or urinary sepsis: A prospective multicenter study. ( 29364923 )
2018
28
Acute Pyelonephritis in Adults. ( 29562155 )
2018
29
Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. ( 29768465 )
2018
30
Acute Pyelonephritis in Adults. ( 29539281 )
2018
31
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )
2018
32
Multiple gas emboli complicating an emphysematous pyelonephritis. ( 29942752 )
2018
33
Pyelonephritis in persons after age 50 as a clinical marker of urogenital cancer. ( 29654872 )
2018
34
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
35
Mecillinam for the treatment of acute pyelonephritis and bacteremia caused by Enterobacteriaceae: a literature review. ( 29872326 )
2018
36
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis. ( 29563947 )
2018
37
Characterization of subclinical bacteriuria, bacterial cystitis, and pyelonephritis in dogs with chronic kidney disease. ( 29701531 )
2018
38
Xanthogranulomatous Pyelonephritis: A Complicated Febrile Urinary Tract Infection Detected by Point-of-Care Ultrasound in the Emergency Department. ( 29753570 )
2018
39
Colonization of preservation solution in kidney transplantation: Clinical impact and risk of secondary acute graft pyelonephritis. ( 29395835 )
2018
40
Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis. ( 29473304 )
2018
41
Erratum: Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis [Corrigendum]. ( 29497327 )
2018
42
Acute infectious aortitis presenting as pyelonephritis. ( 29903668 )
2018
43
Efficacy and Cost Comparison of Ertapenem as Outpatient Parenteral Antimicrobial Therapy in Acute Pyelonephritis due to Extended-spectrum Beta-lactamase-producing Enterobacteriaceae. ( 30270995 )
2018
44
Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing. ( 30304506 )
2018
45
Management of acute pyelonephritis. ( 30324991 )
2018
46
ACR Appropriateness Criteria® Acute Pyelonephritis. ( 30392592 )
2018
47
Preventive Effect of L-Carnitine on Scar Formation During Acute Pyelonephritis: A Randomized Placebo-Controlled Trial. ( 30418227 )
2018
48
Giant hydronephrosis presenting as acute pyelonephritis. ( 30418837 )
2018
49
Mild encephalopathy/encephalitis with a reversible splenial lesion associated with acute pyelonephritis: A case report. ( 30446174 )
2018
50
Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease. ( 30456557 )
2018

Variations for Pyelonephritis

Expression for Pyelonephritis

Search GEO for disease gene expression data for Pyelonephritis.

Pathways for Pyelonephritis

Pathways related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL2 CRP CXCL8 CXCR1 CXCR2 IL10
2
Show member pathways
13.84 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
3
Show member pathways
13.68 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
4
Show member pathways
13.52 CCL2 CXCL8 IL10 IL1B IL6 PGF
5
Show member pathways
13.37 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
6
Show member pathways
13.33 CCL2 CXCL8 IL10 IL1B IL6 TNF
7
Show member pathways
13.3 CCL2 CXCL8 CXCR1 CXCR2 IL10 IL1B
8
Show member pathways
13.08 CCL2 CXCL8 CXCR2 IL1B IL6 TLR4
9
Show member pathways
13.01 ACE CCL2 CXCL8 IL10 IL1B IL6
10
Show member pathways
12.87 CXCL8 IL10 IL1B IL6 TNF
11
Show member pathways
12.83 CCL2 CXCL8 IL1B IL6 TLR4 TNF
12
Show member pathways
12.78 CXCL8 IL1B IL6 TLR4 TNF
13
Show member pathways
12.73 IL1B IL6 PGF TLR4 TNF
14
Show member pathways
12.64 IL10 IL1B IL6 TLR4 TNF
15
Show member pathways
12.63 CCL2 IL10 IL1B IL6 TNF
16 12.55 CCL2 IL10 IL1B TNF
17
Show member pathways
12.43 IL10 IL1B IL6 TNF
18
Show member pathways
12.39 CCL2 CXCL8 IL1B IL6 TNF
19
Show member pathways
12.37 CXCL8 IL1B IL6 TLR4 TNF
20
Show member pathways
12.36 ALB CCL2 CRP IL1B IL6 TNF
21
Show member pathways
12.3 CXCL8 IL6 TLR4 TNF
22
Show member pathways
12.3 CXCL8 IL10 IL1B IL6 PGF TNF
23
Show member pathways
12.29 IL10 IL1B TLR4 TNF
24 12.29 IL10 IL1B IL6 TLR4 TNF
25
Show member pathways
12.26 CXCL8 IL1B IL6 TNF
26
Show member pathways
12.26 CCL2 CXCL8 CXCR1 CXCR2 IL1B TLR4
27
Show member pathways
12.25 IL10 IL1B IL6 TNF
28
Show member pathways
12.24 CXCL8 IL1B IL6 TLR4 TNF
29 12.23 CXCL8 IL10 IL1B IL6 TNF
30
Show member pathways
12.12 CCL2 CXCL8 IL10 IL1B IL6 PGF
31
Show member pathways
12.11 IL10 IL1B IL6 TLR4 TNF
32
Show member pathways
12.09 IL1B IL6 TLR4 TNF
33
Show member pathways
12.05 CCL2 CXCL8 CXCR1 CXCR2
34 12.02 CCL2 IL1B IL6 TNF
35 11.99 CCL2 CXCL8 IL1B IL6 TLR4 TNF
36 11.98 IL10 IL6 TNF
37 11.97 CCL2 CXCL8 IL1B IL6 TNF
38 11.95 CXCL8 IL1B TLR4 TNF
39 11.94 CXCL8 IL1B IL6
40 11.94 CCL2 CXCL8 IL10 IL1B IL6 TNF
41 11.9 IL1B IL6 TNF
42 11.9 CXCL8 IL1B IL6 TLR4
43
Show member pathways
11.88 CXCL8 IL6 TLR4
44 11.82 IL10 IL1B IL6 TNF
45 11.81 IL10 IL1B TNF
46 11.78 CXCL8 IL10 IL1B IL6 TLR4 TNF
47 11.76 CCL2 IL10 IL1B IL6 TNF
48
Show member pathways
11.74 CXCL8 IL1B IL6 TNF
49 11.69 CCL2 CXCL8 IL1B IL6 TLR4 TNF
50 11.67 CCL2 CXCL8 IL1B IL6 TNF

GO Terms for Pyelonephritis

Cellular components related to Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ALB CCL2 CRP CXCL8 IL10
2 external side of plasma membrane GO:0009897 9.55 ACE CXCR1 CXCR2 TLR4 TNF
3 extracellular region GO:0005576 9.36 ACE ALB CCL2 CRP CXCL8 IL10

Biological processes related to Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.94 CCL2 CXCL8 CXCR1 CXCR2
2 positive regulation of angiogenesis GO:0045766 9.92 CXCL8 CXCR2 IL1B PGF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TLR4 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.91 CCL2 CXCL8 IL10 IL1B IL6 TNF
5 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 TNF
7 calcium-mediated signaling GO:0019722 9.88 CXCL8 CXCR1 CXCR2
8 cell chemotaxis GO:0060326 9.88 CCL2 CXCR1 CXCR2
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
10 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
11 regulation of signaling receptor activity GO:0010469 9.87 CCL2 CXCL8 IL10 IL1B IL6 PGF
12 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
13 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 IL1B TLR4 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.82 IL1B TLR4 TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IL1B TLR4 TNF
17 receptor internalization GO:0031623 9.81 CXCL8 CXCR1 CXCR2
18 chemokine-mediated signaling pathway GO:0070098 9.81 CCL2 CXCL8 CXCR1 CXCR2
19 protein kinase B signaling GO:0043491 9.8 CCL2 IL1B TNF
20 response to glucocorticoid GO:0051384 9.8 IL10 IL1B IL6 TNF
21 positive regulation of interleukin-6 production GO:0032755 9.78 IL1B IL6 TLR4 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR4 TNF
23 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR4 TNF
24 embryonic digestive tract development GO:0048566 9.74 CXCL8 TNF
25 negative regulation of neurogenesis GO:0050768 9.74 IL1B IL6 TNF
26 dendritic cell chemotaxis GO:0002407 9.73 CXCR1 CXCR2
27 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
28 positive regulation of macrophage activation GO:0043032 9.73 IL10 TLR4
29 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
31 positive regulation of neutrophil chemotaxis GO:0090023 9.73 CXCL8 CXCR2 IL1B
32 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
33 induction of positive chemotaxis GO:0050930 9.72 CXCL8 PGF
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 CCL2 TLR4
35 positive regulation of chemokine production GO:0032722 9.72 IL6 TLR4 TNF
36 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
37 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
38 neutrophil activation GO:0042119 9.71 CXCL8 CXCR2
39 positive regulation of leukocyte chemotaxis GO:0002690 9.71 CXCR2 IL6
40 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
43 cellular response to lipopolysaccharide GO:0071222 9.7 CCL2 CXCL8 IL10 IL1B IL6 TLR4
44 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
45 neutrophil mediated immunity GO:0002446 9.69 ACE IL6
46 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
47 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 TLR4
48 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
50 positive regulation of fever generation GO:0031622 9.67 IL1B TNF

Molecular functions related to Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
2 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 interleukin-8 receptor activity GO:0004918 8.96 CXCR1 CXCR2

Sources for Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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