Pyloric Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PYL006 MIFTS: 46	Pyloric Stenosis Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Pyloric Stenosis

MalaCards integrated aliases for Pyloric Stenosis:

Name: Pyloric Stenosis ¹² ²⁹ ⁵⁵ ⁶ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of oesophagus, stomach and duodenum

Other diseases of stomach and duodenum

Adult hypertrophic pyloric stenosis

External Ids:

Disease Ontology ¹² DOID:12639

ICD10 ³³ K31.1

MeSH ⁴⁴ D011707

NCIt ⁵⁰ C34966

SNOMED-CT ⁶⁸ 367403001

UMLS ⁷³ C0034194

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Summaries for Pyloric Stenosis

MalaCards based summary : Pyloric Stenosis is related to hirschsprung disease 1 and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Neuroscience and Signaling events regulated by Ret tyrosine kinase. The drugs Celecoxib and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : ⁷⁶ Pyloric stenosis is a narrowing of the opening from the stomach to the first part of the small intestine... more...

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Related Diseases for Pyloric Stenosis

Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)

#	Related Disease	Score	Top Affiliating Genes
1	hirschsprung disease 1	29.1	GDNF NOS1 NTRK3 RET
2	hypertrophic pyloric stenosis	28.2	DMD FOXF1 MBNL1 NKX2-5 NOS1 NTF4
3	pyloric stenosis, infantile hypertrophic, 1	12.5
4	pyloric stenosis, infantile hypertrophic, 5	12.2
5	pyloric stenosis, infantile hypertrophic, 4	12.1
6	pyloric stenosis, infantile hypertrophic, 2	12.1
7	pyloric stenosis, infantile hypertrophic, 3	12.1
8	intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome	12.0
9	acquired gastric outlet stenosis	11.8
10	duodenal atresia	11.1
11	congenital generalized lipodystrophy	11.1
12	epidermolysis bullosa junctionalis with pyloric atresia	11.1
13	type c thymoma	10.4	NTRK3 SST
14	medullary sponge kidney	10.3	GDNF RET
15	interatrial communication	10.3	DMD NKX2-5
16	esophagitis	10.3
17	hypoganglionosis	10.2	GDNF RET
18	aging	10.2
19	pylorospasm	10.2
20	ectopic cushing syndrome	10.2	RET SST
21	jejunoileitis	10.2	GDNF NOS1
22	multiple endocrine neoplasia, type iib	10.2	GDNF RET
23	gastric cancer	10.1
24	tracheoesophageal fistula with or without esophageal atresia	10.1
25	esophageal atresia	10.1
26	gastroenteritis	10.1
27	eosinophilic gastroenteritis	10.1
28	neuronitis	10.1
29	duodenitis	10.1
30	eosinophilic enteropathy	10.1
31	goldberg-shprintzen syndrome	10.0	GDNF RET
32	tetralogy of fallot	10.0	NKX2-5 NTRK3 RET
33	crohn's disease	10.0
34	mucositis	10.0
35	epidermolysis bullosa	10.0
36	tracheoesophageal fistula	10.0
37	colonic disease	10.0	GDNF RET
38	gilbert syndrome	10.0
39	ichthyosis, x-linked	10.0
40	pertussis	10.0
41	heart disease	10.0
42	pneumatosis cystoides intestinalis	10.0
43	ichthyosis	10.0
44	gastric dilatation	10.0
45	pancreatitis	10.0
46	gastroesophageal reflux	9.9
47	diaphragmatic hernia, congenital	9.9
48	jejunal atresia	9.9
49	myasthenia gravis	9.9
50	gastric ulcer	9.9

Graphical network of the top 20 diseases related to Pyloric Stenosis:

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Symptoms & Phenotypes for Pyloric Stenosis

MGI Mouse Phenotypes related to Pyloric Stenosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.2	TRPC6 DMD GDNF HDC MBNL1 NOS1
2	cardiovascular system	MP:0005385	10.09	DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
3	growth/size/body region	MP:0005378	10.07	GDNF HDC MBNL1 NKX2-5 NOS1 NTF4
4	mortality/aging	MP:0010768	10.02	DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
5	digestive/alimentary	MP:0005381	9.95	NKX2-5 NOS1 RET SST DMD FOXF1
6	nervous system	MP:0003631	9.93	DMD GDNF HDC MBNL1 NKX2-5 NOS1
7	muscle	MP:0005369	9.86	DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
8	no phenotypic analysis	MP:0003012	9.56	DMD HDC NKX2-5 NOS1 NTRK3 RET
9	respiratory system	MP:0005388	9.1	NOS1 NTRK3 RET DMD FOXF1 NKX2-5

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Drugs & Therapeutics for Pyloric Stenosis

Drugs for Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Celecoxib

Approved, Investigational

Phase 4,Phase 3

169590-42-5

2662

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3

73590-58-6

4594

Ibuprofen

Approved

Phase 4,Phase 3

15687-27-1

3672

Naproxen

Approved, Vet_approved

Phase 4,Phase 3

22204-53-1

1302 156391

Analgesics

Phase 4,Phase 3

Analgesics, Non-Narcotic

Phase 4,Phase 3

Antacids

Phase 4,Phase 3,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 3

Antirheumatic Agents

Phase 4,Phase 3

Anti-Ulcer Agents

Phase 4,Phase 3,Not Applicable

Cyclooxygenase 2 Inhibitors

Phase 4,Phase 3

Cyclooxygenase Inhibitors

Phase 4,Phase 3

Gastrointestinal Agents

Phase 4,Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3

Proton Pump Inhibitors

Phase 4,Phase 3,Not Applicable

Midazolam

Approved, Illicit

Phase 3

59467-70-8

4192

Famotidine

Approved

Phase 3

76824-35-6

3325

Histamine

Approved, Investigational

Phase 3

75614-87-8, 51-45-6

774

Aspirin

Approved, Vet_approved

Phase 3

50-78-2

2244

Dexlansoprazole

Approved, Investigational

Phase 3

138530-94-6, 103577-45-3

9578005

Lansoprazole

Approved, Investigational

Phase 3

103577-45-3

3883

Clopidogrel

Approved

Phase 3

120202-66-6, 113665-84-2

60606

Ticlopidine

Approved

Phase 3

55142-85-3

5472

Histamine Antagonists

Phase 3

Histamine H2 Antagonists

Phase 3

Histamine Phosphate

Phase 3

51-74-1

65513

Neurotransmitter Agents

Phase 3,Not Applicable

Antipyretics

Phase 3

Fibrinolytic Agents

Phase 3

Platelet Aggregation Inhibitors

Phase 3

Anesthetics

Phase 2, Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 3

Purinergic P2 Receptor Antagonists

Phase 3

Purinergic P2Y Receptor Antagonists

Phase 3

Acetaminophen

Approved

103-90-2

1983

Azithromycin

Approved

Not Applicable

83905-01-5

55185 447043

Cefazolin

Approved

Not Applicable

25953-19-9

656510 33255

Clindamycin

Approved, Vet_approved

Not Applicable

18323-44-9

29029

Esomeprazole

Approved, Investigational

Not Applicable

161796-78-7, 119141-88-7

4594 9579578

Methylene blue

Approved, Investigational

Not Applicable

61-73-4

Bupivacaine

Approved, Investigational

2180-92-9, 38396-39-3

2474

Epinephrine

Approved, Vet_approved

51-43-4

5816

Fentanyl

Approved, Illicit, Investigational, Vet_approved

437-38-7

3345

Propofol

Approved, Investigational, Vet_approved

2078-54-8

4943

Racepinephrine

Approved

329-65-7

838

Rocuronium

Approved

119302-91-9, 143558-00-3

441290

Sevoflurane

Approved, Vet_approved

28523-86-6

5206

Citric Acid

Approved, Nutraceutical, Vet_approved

Not Applicable

77-92-9

311

Interventional clinical trials:

(show all 41)

#	Name	Status	NCT ID	Phase	Drugs
1	Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction	Unknown status	NCT02156505	Phase 4
2	RCT: STARR vs Biofeedback	Completed	NCT00556283	Phase 4
3	Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis	Completed	NCT00141102	Phase 4	Celecoxib;Diclofenac + Omeprazole
4	GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)	Completed	NCT00373685	Phase 4	Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
5	Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen	Completed	NCT00346216	Phase 4	celecoxib;Ibuprofen;Naproxen
6	Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis	Completed	NCT00195949	Phase 3
7	Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction	Completed	NCT01646476	Phase 3
8	Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment	Completed	NCT00450216	Phase 3	Ibuprofen/famotidine;Ibuprofen
9	Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers	Completed	NCT00450658	Phase 3	HZT-501;Ibuprofen
10	A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin	Completed	NCT00175032	Phase 3	Lansoprazole and naproxen and aspirin;Celecoxib and aspirin
11	Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy	Recruiting	NCT02784470	Phase 3
12	Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer	Recruiting	NCT02064803	Phase 3
13	Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial.	Not yet recruiting	NCT03223831	Phase 3
14	EUS - Guided Balloon-occluded Gastrojejunostomy Bypass	Not yet recruiting	NCT03223480	Phase 2, Phase 3
15	Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)	Terminated	NCT00557921	Phase 3	CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
16	Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD	Withdrawn	NCT01025739	Phase 2
17	Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis	Unknown status	NCT00409734
18	The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents	Unknown status	NCT02440724	Not Applicable
19	The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood	Unknown status	NCT01159509
20	Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis	Unknown status	NCT00144924	Not Applicable
21	Biliary Drainage in Patients With Duodenal Metal Stent	Unknown status	NCT02376907
22	Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis	Unknown status	NCT02564965	Not Applicable
23	Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis	Completed	NCT01139853	Early Phase 1
24	Gastric Outlet Obstructions Tailored Covered Stents for GOO	Completed	NCT02299258	Not Applicable
25	EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms	Completed	NCT00991614
26	ComVi and D-type Stent in Malignant GOO	Completed	NCT01839292	Not Applicable
27	Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy	Completed	NCT02359305		Acetaminophen;Acetaminophen
28	Different Feeding Methods After Pyloromyotomy	Completed	NCT01509417	Not Applicable
29	Covered Self-expandable Metallic Stents Insertion Using Clips and Suture Materials for Preventing Migration	Completed	NCT02193789	Not Applicable
30	Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection	Completed	NCT01235546	Not Applicable	Azithromycin and standard of care;Placebo and standard of care
31	Natural History of Infants With Patent Processus Vaginalis	Recruiting	NCT03042858
32	Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China	Recruiting	NCT03040817	Not Applicable	Esomeprazole + Mosapride
33	Evaluation of the Efficacy of Duodenal Prostheses Not Covered Over 6 Years	Recruiting	NCT03463668
34	Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation (IRE) System	Recruiting	NCT02041936	Not Applicable
35	Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy	Enrolling by invitation	NCT02775214	Not Applicable
36	EUS-GE vs ES for Palliation of GOO	Not yet recruiting	NCT03259763	Not Applicable
37	Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia	Not yet recruiting	NCT02879292
38	Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study	Not yet recruiting	NCT03095144
39	Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction	Terminated	NCT00487552	Not Applicable
40	Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head	Terminated	NCT00753441	Not Applicable
41	Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer	Withdrawn	NCT01569282	Not Applicable

Search NIH Clinical Center for Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis

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Genetic Tests for Pyloric Stenosis

Genetic tests related to Pyloric Stenosis:

#	Genetic test	Affiliating Genes
1	Pyloric Stenosis ²⁹

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Anatomical Context for Pyloric Stenosis

MalaCards organs/tissues related to Pyloric Stenosis:

⁴¹

Small Intestine, Pancreas, Heart, Kidney, Liver, Smooth Muscle, Testes

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Publications for Pyloric Stenosis

Articles related to Pyloric Stenosis:

(show top 50) (show all 829)

#	Title	Authors	Year
1	Perioperative Complications of Surgery for Hypertrophic Pyloric Stenosis. ( 29510427 )	Kelay A....Hall N.J.	2018
2	The incidence of infantile hypertrophic pyloric stenosis and its association with folic acid supplementation during pregnancy: A nested case-control study. ( 29884554 )	Rosenthal Y.S....Koren G.	2018
3	Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon. ( 29338765 )	Ndongo R....Minkande J.Z.	2018
4	Placement of a lumen-apposing metal stent for palliation of malignant pyloric stenosis. ( 29895067 )	Trindade A.J....Benias P.C.	2018
5	Pyloric stenosis: an enigma more than a century after the first successful treatment. ( 29030700 )	El-Gohary Y....Murphy A.J.	2018
6	Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )	Kaye P.	2018
7	Adult idiopathic hypertrophic pyloric stenosis - a common presentation with an uncommon diagnosis. ( 29686790 )	Hassan S.M....Haq F.	2018
8	Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a survey of 407 children. ( 29411105 )	Binet A....Lardy H.	2018
9	Current perioperative care of infants with pyloric stenosis: comparison of survey results. ( 29157882 )	Cartabuke R.S....Tumin D.	2018
10	Case of hepatic portal venous gas in an infant with hypertrophic pyloric stenosis. ( 29980514 )	Daniel S....Chawla A.	2018
11	Palliation of Malignant Pyloric Stenosis Using a Lumen-Apposing Metal Stent. ( 29609066 )	Trindade A.J....Benias P.C.	2018
12	Postoperative outcomes of open versus laparoscopic pyloromyotomy for hypertrophic pyloric stenosis. ( 29506847 )	Costanzo C.M....Berman L.	2018
13	Transient neonatal myasthenia gravis with infantile hypertrophic pyloric stenosis: coincidence or causation? ( 29099348 )	Pandita A....Leelakumar V.	2017
14	The treatment of pyloric stenosis: Evolution in practice. ( 29148193 )	Taghavi K....McBride C.A.	2017
15	Epidemiological and clinical characteristics of 304 patients with infantile hypertrophic pyloric stenosis in Anhui Province of East China, 2012-2015. ( 28701060 )	Li J....Liu X.	2017
16	Atropine Treatment for Hypertrophic Pyloric Stenosis: A Systematic Review and Meta-analysis. ( 28701002 )	Lauriti G....Zani A.	2017
17	50 Years Ago in The Journal of Pediatrics: The Radiographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis. ( 28648281 )	Cuello-Garcia C.A.	2017
18	Caterpillar Sign in Infantile Hypertrophic Pyloric Stenosis. ( 29236645 )	Martinez-Leo B....Garcia-Cabello L.M.	2017
19	A breathtakingly rare presentation of pyloric stenosis. ( 28665094 )	Hurley S.A....O'Grady M.J.	2017
20	Excessive Bright Echoes Sign for Hypertrophic Pyloric Stenosis Suggest the Diagnosis: Gastric Pneumatosis and Portal Venous Gas in Infants Suggest HPS. ( 28295432 )	Cohen H.L....Radtke I.	2017
21	Corrected to uncorrected? The metabolic conundrum of hypertrophic pyloric stenosis. ( 28189444 )	Yanchar N.L....Rangu S.	2017
22	Population-level surgical outcomes for infantile hypertrophic pyloric stenosis. ( 28576429 )	Lansdale N....Kenny S.E.	2017
23	Use of a lumen-apposing metal stent to treat pyloric stenosis. ( 28389214 )	Adler D.G.	2017
24	Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. ( 28318599 )	Zhu J....Mu D.	2017
25	Application of color Doppler ultrasound combined with Doppler imaging artifacts in the diagnosis and estimate of congenital hypertrophic pyloric stenosis. ( 28842652 )	Ma S....Wei H.	2017
26	Consideration of pyloric stenosis as a cause of feeding dysfunction in children with cyanotic heart disease. ( 28928620 )	Srivastava N.T....Schamberger M.S.	2017
27	A Difficult Recurrent Hypertrophic Pyloric Stenosis. ( 28770145 )	Louati H....Boudawara T.	2017
28	Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis? ( 28550912 )	Nissen M....TrAPbs R.B.	2017
29	Immediate Emergency Department Diagnosis of Pyloric Stenosis with Point-of-care Ultrasound. ( 29849342 )	Dorinzi N....Minardi J.	2017
30	Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )	Ogunlesi T.A....Ogunfowora O.B.	2016
31	Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )	Holder J....Samin A.	2016
32	No association between macrolide treatment in infancy and later pyloric stenosis in Sweden. ( 26694588 )	Ludvigsson J.F....Almqvist C.	2016
33	Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )	Wu S.F....Lin H.C.	2016
34	Prematurity Affects Age of Presentation of Pyloric Stenosis. ( 27149987 )	Costanzo C.M....Berman L.	2016
35	Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )	Ednie A.C....Yanchar N.	2016
36	Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )	SA!nchez GarcA-a S....GonzA!lez SA!nchez S.	2016
37	Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. ( 27528563 )	Miyata S....Bliss D.W.	2016
38	Optimizing fluid resuscitation in hypertrophic pyloric stenosis. ( 26876090 )	Dalton B.G....St Peter S.D.	2016
39	Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. ( 27506212 )	Wolf L.L....Buchmiller T.L.	2016
40	Recurrent pyloric stenosis. ( 27389044 )	Al-Ansari A....Altokhais T.I.	2016
41	Adult idiopathic hypertrophic pyloric stenosis. ( 27362602 )	Richards S....McCarthy G.	2016
42	Pitfall in the remote imaging of pyloric stenosis. ( 27260853 )	Lampl B.S....Vogelius E.	2016
43	Cost of Hospitalization for Infantile Pyloric Stenosis. ( 26802838 )	Hajiran C.J....Nakayama D.K.	2016
44	Health disparities in infants with hypertrophic pyloric stenosis. ( 27586849 )	Feliz A....Savoie K.B.	2016
45	Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. ( 27292596 )	Mahida J.B....Groner J.I.	2016
46	Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 27655365 )	Murchison L....Eaton S.	2016
47	Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? ( 27251656 )	Badebarin D....Zarrintan S.	2016
48	A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. ( 27829521 )	Markel T.A....Ladd A.P.	2016
49	Idiopathic pyloric stenosis. ( 28154715 )	Manatakis D....Sioula M.	2016
50	Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. ( 26944185 )	Wayne C....Nasr A.	2016

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Genes for Pyloric Stenosis

Genes related to Pyloric Stenosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NOS1	Nitric Oxide Synthase 1	Protein Coding	49.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Functions Variants (show sections)	11283889 14757827 9354728 (more) 15361336 1378938 17590189 16758311 10784584 7546628 17262047 10630682 9660065 19851341 12768383
2	FOXF1	Forkhead Box F1	Protein Coding	30.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
3	NKX2-5	NK2 Homeobox 5	Protein Coding	22.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MBNL1	Muscleblind Like Splicing Regulator 1	Protein Coding	21.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	21.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SST	Somatostatin	Protein Coding	21.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	Protein Coding	21.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	RET	Ret Proto-Oncogene	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	DMD	Dystrophin	Protein Coding	20.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	HDC	Histidine Decarboxylase	Protein Coding	20.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	NTF4	Neurotrophin 4	Protein Coding	20.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	20.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	20.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Pyloric Stenosis

ClinVar genetic disease variations for Pyloric Stenosis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1		46;XY;t(2;13)(p25.2;q31.3)dn	Translocation	Uncertain significance
2	CHD7	NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter)	single nucleotide variant	Likely pathogenic	rs367557471	GRCh37	Chromosome 8, 61734614: 61734614
3	CHD7	NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter)	single nucleotide variant	Likely pathogenic	rs367557471	GRCh38	Chromosome 8, 60822055: 60822055

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Expression for Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

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Pathways for Pyloric Stenosis

Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.46	NOS1 NTRK3 RET TRPC6
2	Signaling events regulated by Ret tyrosine kinase ¹	10.84	GDNF RET
3	TRP channels ⁶⁶	10.55	TRPC5 TRPC6
4	Muscular Dystrophies and Dystrophin-Glycoprotein Complex ⁶⁴	10.23	DMD NOS1

Sources

GO Terms for Pyloric Stenosis

Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:0043025	9.46	DMD RET SST TRPC5
2	axon	GO:0030424	9.26	DMD NTF4 NTRK3 RET
3	membrane raft	GO:0045121	8.92	DMD NOS1 RET TRPC5

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	9.93	DMD FOXF1 NKX2-5 NTRK3 RET
2	negative regulation of apoptotic process	GO:0043066	9.87	GDNF NKX2-5 NTRK3 RET
3	positive regulation of cell migration	GO:0030335	9.73	FOXF1 NTRK3 RET
4	nervous system development	GO:0007399	9.72	GDNF MBNL1 NTRK3 RET TRPC5
5	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.65	NTF4 NTRK3 RET
6	positive regulation of cell proliferation	GO:0008284	9.65	DMD GDNF NKX2-5 NTRK3 TRPC5
7	positive regulation of peptidyl-threonine phosphorylation	GO:0010800	9.55	TRPC5 TRPC6
8	peripheral nervous system development	GO:0007422	9.52	GDNF NTF4
9	regulation of cardiac muscle contraction	GO:0055117	9.51	NKX2-5 NOS1
10	innervation	GO:0060384	9.49	NTF4 RET
11	regulation of ryanodine-sensitive calcium-release channel activity	GO:0060314	9.46	DMD NOS1
12	enteric nervous system development	GO:0048484	9.43	GDNF RET
13	manganese ion transport	GO:0006828	9.4	TRPC5 TRPC6
14	negative regulation of dendrite morphogenesis	GO:0050774	9.37	TRPC5 TRPC6
15	neuron differentiation	GO:0030182	9.26	DMD RET TRPC5 TRPC6
16	mechanoreceptor differentiation	GO:0042490	9.16	NTF4 NTRK3
17	positive regulation of neuron differentiation	GO:0045666	8.92	DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inositol 1,4,5 trisphosphate binding	GO:0070679	9.16	TRPC5 TRPC6
2	actinin binding	GO:0042805	8.96	TRPC5 TRPC6
3	store-operated calcium channel activity	GO:0015279	8.62	TRPC5 TRPC6

Sources

Sources for Pyloric Stenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia