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MCID: PYL006
MIFTS: 47

Pyloric Stenosis

Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Pyloric Stenosis

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MalaCards integrated aliases for Pyloric Stenosis:

Name: Pyloric Stenosis 12 29 55 6 44 15 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:12639
ICD10 33 K31.1
MeSH 44 D011707
NCIt 50 C34966
UMLS 73 C0034194
Sources

Summaries for Pyloric Stenosis

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MalaCards based summary : Pyloric Stenosis is related to hypertrophic pyloric stenosis and hirschsprung disease 1. An important gene associated with Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are G-protein signaling_H-RAS regulation pathway and Signaling events regulated by Ret tyrosine kinase. The drugs Diclofenac and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Pyloric stenosis is a narrowing of the opening from the stomach to the first part of the small intestine... more...

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Related Diseases for Pyloric Stenosis

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Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 hypertrophic pyloric stenosis 32.5 DMD FOXF1 HMOX2 MBNL1 NKX2-5 NOS1
2 hirschsprung disease 1 29.3 GDNF HMOX2 NOS1 RET
3 pyloric stenosis, infantile hypertrophic, 1 12.6
4 pyloric stenosis, infantile hypertrophic, 5 12.3
5 pyloric stenosis, infantile hypertrophic, 4 12.3
6 pyloric stenosis, infantile hypertrophic, 2 12.3
7 pyloric stenosis, infantile hypertrophic, 3 12.3
8 intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome 12.2
9 acquired gastric outlet stenosis 12.0
10 duodenal atresia 11.2
11 congenital generalized lipodystrophy 11.2
12 epidermolysis bullosa junctionalis with pyloric atresia 11.2
13 pylorospasm 10.4
14 tracheoesophageal fistula with or without esophageal atresia 10.3
15 esophageal atresia 10.3
16 gastric cancer 10.3
17 gastroenteritis 10.3
18 gastric ulcer 10.2
19 eosinophilic gastroenteritis 10.2
20 eosinophilic enteropathy 10.2
21 crohn's disease 10.2
22 duodenal ulcer 10.2
23 tracheoesophageal fistula 10.2
24 heart disease 10.1
25 adenomyoma 10.1
26 epidermolysis bullosa 10.1
27 achalasia 10.1
28 interatrial communication 10.1 DMD NKX2-5
29 gilbert syndrome 10.1
30 ichthyosis, x-linked 10.1
31 pertussis 10.1
32 pneumatosis cystoides intestinalis 10.1
33 ichthyosis 10.1
34 gastric dilatation 10.1
35 gastritis 10.1
36 peptic ulcer disease 10.1
37 ectopic cushing syndrome 10.1 RET SST
38 muscular dystrophy, becker type 10.1 DMD NOS1
39 gastroesophageal reflux 10.0
40 diaphragmatic hernia, congenital 10.0
41 jejunal atresia 10.0
42 myasthenia gravis 10.0
43 muscle hypertrophy 10.0
44 pulmonary hypertension 10.0
45 microinvasive gastric cancer 10.0
46 esophagitis 10.0
47 neonatal myasthenia gravis 10.0
48 dyspepsia 10.0
49 junctional epidermolysis bullosa 10.0
50 situs inversus 10.0

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to Pyloric Stenosis
Sources

Symptoms & Phenotypes for Pyloric Stenosis

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MGI Mouse Phenotypes related to Pyloric Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 DMD GDNF HDC HMOX2 MBNL1 NOS1
2 cardiovascular system MP:0005385 10.11 DMD FOXF1 GDNF HMOX2 MBNL1 NKX2-5
3 growth/size/body region MP:0005378 10.06 DMD GDNF HDC MBNL1 NKX2-5 NOS1
4 digestive/alimentary MP:0005381 10.03 DMD FOXF1 GDNF HMOX2 NKX2-5 NOS1
5 homeostasis/metabolism MP:0005376 10.02 DMD HDC HMOX2 NKX2-5 NOS1 NTF4
6 mortality/aging MP:0010768 10.02 DMD FOXF1 GDNF HMOX2 MBNL1 NKX2-5
7 nervous system MP:0003631 9.93 DMD GDNF HDC HMOX2 MBNL1 NKX2-5
8 muscle MP:0005369 9.91 DMD FOXF1 GDNF HMOX2 MBNL1 NKX2-5
9 no phenotypic analysis MP:0003012 9.5 DMD HDC NKX2-5 NOS1 RET SST
10 respiratory system MP:0005388 9.1 DMD FOXF1 HMOX2 NKX2-5 NOS1 RET
Sources

Drugs & Therapeutics for Pyloric Stenosis

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Drugs for Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
3
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
4
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
5
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
6
Azithromycin Approved Phase 4,Not Applicable 83905-01-5 55185 447043
7 tannic acid Approved Phase 4
8
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
9 Anti-Ulcer Agents Phase 4,Phase 3,Not Applicable
10 Anti-Inflammatory Agents Phase 4,Phase 3
11 Antirheumatic Agents Phase 4,Phase 3
12 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
13 Cyclooxygenase Inhibitors Phase 4,Phase 3
14 Analgesics Phase 4,Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
16 Proton Pump Inhibitors Phase 4,Phase 3,Not Applicable
17 Analgesics, Non-Narcotic Phase 4,Phase 3
18 Antacids Phase 4,Phase 3,Not Applicable
19 Peripheral Nervous System Agents Phase 4,Phase 3
20 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
21
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
22
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
23
Famotidine Approved Phase 3 76824-35-6 3325
24
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
25
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
26
Dexlansoprazole Approved, Investigational Phase 3 103577-45-3, 138530-94-6 9578005
27
Ticlopidine Approved Phase 3 55142-85-3 5472
28
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
29 Anesthetics Phase 2, Phase 3
30 Neurotransmitter Agents Phase 3,Not Applicable
31 Histamine Antagonists Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33 Histamine H2 Antagonists Phase 3
34 Fibrinolytic Agents Phase 3
35 Antipyretics Phase 3
36 Platelet Aggregation Inhibitors Phase 3
37 Purinergic P2Y Receptor Antagonists Phase 3
38 Purinergic P2 Receptor Antagonists Phase 3
39 Cytochrome P-450 Enzyme Inhibitors Phase 3
40 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
41
Acetaminophen Approved 103-90-2 1983
42
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
43
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
44
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 119141-88-7 4594 9579578
45
Methylene blue Approved, Investigational Not Applicable 61-73-4
46
Sevoflurane Approved, Vet_approved 28523-86-6 5206
47
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
48
Racepinephrine Approved 329-65-7 838
49
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
50
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
2 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
3 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed NCT00141102 Phase 4 Celecoxib;Diclofenac + Omeprazole
4 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
5 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
6 MORDOR II Burkina Faso Neonates Not yet recruiting NCT03682653 Phase 4 Azithromycin;Placebo
7 MORDOR II Burkina Faso: Longitudinal Trial Not yet recruiting NCT03676751 Phase 4 Azithromycin;Placebo
8 Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis Completed NCT00195949 Phase 3
9 Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction Completed NCT01646476 Phase 3
10 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3 Ibuprofen/famotidine;Ibuprofen
11 Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers Completed NCT00450658 Phase 3 HZT-501;Ibuprofen
12 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3 Lansoprazole and naproxen and aspirin;Celecoxib and aspirin
13 Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial. Recruiting NCT03223831 Phase 3
14 EUS - Guided Balloon-occluded Gastrojejunostomy Bypass Recruiting NCT03223480 Phase 2, Phase 3
15 Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy Recruiting NCT02784470 Phase 3
16 Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer Recruiting NCT02064803 Phase 3
17 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
18 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
19 The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents Unknown status NCT02440724 Not Applicable
20 The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood Unknown status NCT01159509
21 Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis Unknown status NCT00144924 Not Applicable
22 Biliary Drainage in Patients With Duodenal Metal Stent Unknown status NCT02376907
23 Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia Unknown status NCT02879292
24 Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis Completed NCT00409734
25 Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis Completed NCT01139853 Early Phase 1
26 Gastric Outlet Obstructions Tailored Covered Stents for GOO Completed NCT02299258 Not Applicable
27 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
28 ComVi and D-type Stent in Malignant GOO Completed NCT01839292 Not Applicable
29 Changes in Cerebral Oxygenation During Laparoscopic Pyloromyotomy Completed NCT03650842 Not Applicable
30 Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy Completed NCT02359305 Acetaminophen;Acetaminophen
31 Different Feeding Methods After Pyloromyotomy Completed NCT01509417 Not Applicable
32 Covered Self-expandable Metallic Stents Insertion Using Clips and Suture Materials for Preventing Migration Completed NCT02193789 Not Applicable
33 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care
34 EUS-GE vs ES for Palliation of GOO Recruiting NCT03259763 Not Applicable
35 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
36 Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China Recruiting NCT03040817 Not Applicable Esomeprazole + Mosapride
37 Evaluation of the Efficacy of Duodenal Prostheses Not Covered Over 6 Years Recruiting NCT03463668
38 Ablation of Unresectable Locally Advanced Pancreatic Cancer With Nanoknife Irreversible Electroporation (IRE) System: Response and Tolerability Recruiting NCT03614910
39 Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation (IRE) System Recruiting NCT02041936 Not Applicable
40 Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy Enrolling by invitation NCT02775214 Not Applicable
41 Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study Not yet recruiting NCT03095144
42 Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis Not yet recruiting NCT02564965 Not Applicable
43 Pyloroplasty Versus No Pyloroplasty in Patients Undergoing Esophagectomy Not yet recruiting NCT03740542 Not Applicable
44 Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction Terminated NCT00487552 Not Applicable
45 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Terminated NCT00753441 Not Applicable
46 Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer Withdrawn NCT01569282 Not Applicable

Search NIH Clinical Center for Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis

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Genetic Tests for Pyloric Stenosis

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Genetic tests related to Pyloric Stenosis:

# Genetic test Affiliating Genes
1 Pyloric Stenosis 29
Sources

Anatomical Context for Pyloric Stenosis

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MalaCards organs/tissues related to Pyloric Stenosis:

41
Small Intestine, Pancreas, Heart, Kidney, Bone, Spinal Cord, Thyroid
Sources

Publications for Pyloric Stenosis

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Articles related to Pyloric Stenosis:

(show top 50) (show all 1286)
# Title Authors Year
1
Effects of Hospital Volume on Patient Outcomes and Costs in Infants With Pyloric Stenosis. ( 30502289 )
2019
2
Perioperative Complications of Surgery for Hypertrophic Pyloric Stenosis. ( 29510427 )
2018
3
The incidence of infantile hypertrophic pyloric stenosis and its association with folic acid supplementation during pregnancy: A nested case-control study. ( 29884554 )
2018
4
Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon. ( 29338765 )
2018
5
Placement of a lumen-apposing metal stent for palliation of malignant pyloric stenosis. ( 29895067 )
2018
6
Pyloric stenosis: an enigma more than a century after the first successful treatment. ( 29030700 )
2018
7
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
8
Adult idiopathic hypertrophic pyloric stenosis - a common presentation with an uncommon diagnosis. ( 29686790 )
2018
9
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a survey of 407 children. ( 29411105 )
2018
10
Current perioperative care of infants with pyloric stenosis: comparison of survey results. ( 29157882 )
2018
11
Case of hepatic portal venous gas in an infant with hypertrophic pyloric stenosis. ( 29980514 )
2018
12
Palliation of Malignant Pyloric Stenosis Using a Lumen-Apposing Metal Stent. ( 29609066 )
2018
13
Postoperative outcomes of open versus laparoscopic pyloromyotomy for hypertrophic pyloric stenosis. ( 29506847 )
2018
14
ACTG2-Associated Visceral Myopathy With Chronic Intestinal Pseudoobstruction, Intestinal Malrotation, Hypertrophic Pyloric Stenosis, Choledochal Cyst, and a Novel Missense Mutation. ( 30019982 )
2018
15
Cytomegalovirus gastroenteritis with pyloric stenosis and persistent malabsorption in a patient with common variable immunodeficiency. ( 30403390 )
2018
16
Implementation of a Quality Control System for Laparoscopic Pyloromyotomy in Hypertrophic Pyloric Stenosis: Hurdles and Pitfalls. ( 30086575 )
2018
17
Hypertrophic pyloric stenosis following persistent pulmonary hypertension of the newborn: a case report and literature review. ( 30176827 )
2018
18
Hypertrophic pyloric stenosis following repair of oesophageal atresia and tracheo-oesophageal fistula in a neonate. ( 30244227 )
2018
19
Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis. ( 30281099 )
2018
20
The Application of Pyloric chisel in the Treatment of Hypertrophic Pyloric Stenosis by Single-Site Umbilical Laparoscopic Pyloromyotomy. ( 30289351 )
2018
21
Developmental outcome at 3 years of age of infants following surgery for infantile hypertrophic pyloric stenosis. ( 30402682 )
2018
22
Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 30470884 )
2018
23
Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010. ( 30549250 )
2018
24
Retrospective Cohort Study on the Optimal Timing of Orogastric Tube/Nasogastric Tube Insertion in Infants With Pyloric Stenosis. ( 30234537 )
2018
25
Recurrent Pyloric Stenosis. ( 30269705 )
2018
26
Recurrent Pyloric Stenosis. ( 30454496 )
2018
27
Transient neonatal myasthenia gravis with infantile hypertrophic pyloric stenosis: coincidence or causation? ( 29099348 )
2017
28
The treatment of pyloric stenosis: Evolution in practice. ( 29148193 )
2017
29
Epidemiological and clinical characteristics of 304 patients with infantile hypertrophic pyloric stenosis in Anhui Province of East China, 2012-2015. ( 28701060 )
2017
30
Atropine Treatment for Hypertrophic Pyloric Stenosis: A Systematic Review and Meta-analysis. ( 28701002 )
2017
31
50 Years Ago in The Journal of Pediatrics: The Radiographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis. ( 28648281 )
2017
32
Caterpillar Sign in Infantile Hypertrophic Pyloric Stenosis. ( 29236645 )
2017
33
A breathtakingly rare presentation of pyloric stenosis. ( 28665094 )
2017
34
Excessive Bright Echoes Sign for Hypertrophic Pyloric Stenosis Suggest the Diagnosis: Gastric Pneumatosis and Portal Venous Gas in Infants Suggest HPS. ( 28295432 )
2017
35
Corrected to uncorrected? The metabolic conundrum of hypertrophic pyloric stenosis. ( 28189444 )
2017
36
Population-level surgical outcomes for infantile hypertrophic pyloric stenosis. ( 28576429 )
2017
37
Use of a lumen-apposing metal stent to treat pyloric stenosis. ( 28389214 )
2017
38
Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. ( 28318599 )
2017
39
Application of color Doppler ultrasound combined with Doppler imaging artifacts in the diagnosis and estimate of congenital hypertrophic pyloric stenosis. ( 28842652 )
2017
40
Consideration of pyloric stenosis as a cause of feeding dysfunction in children with cyanotic heart disease. ( 28928620 )
2017
41
A Difficult Recurrent Hypertrophic Pyloric Stenosis. ( 28770145 )
2017
42
Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis? ( 28550912 )
2017
43
Immediate Emergency Department Diagnosis of Pyloric Stenosis with Point-of-care Ultrasound. ( 29849342 )
2017
44
Congenital transpositions of stomach and spleens with partial pyloric stenosis. ( 30363273 )
2017
45
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )
2016
46
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )
2016
47
No association between macrolide treatment in infancy and later pyloric stenosis in Sweden. ( 26694588 )
2016
48
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )
2016
49
Prematurity Affects Age of Presentation of Pyloric Stenosis. ( 27149987 )
2016
50
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )
2016
Sources

Variations for Pyloric Stenosis

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ClinVar genetic disease variations for Pyloric Stenosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHD7 NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter) single nucleotide variant Likely pathogenic rs367557471 GRCh37 Chromosome 8, 61734614: 61734614
2 CHD7 NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter) single nucleotide variant Likely pathogenic rs367557471 GRCh38 Chromosome 8, 60822055: 60822055
Sources

Expression for Pyloric Stenosis

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Search GEO for disease gene expression data for Pyloric Stenosis.
Sources

Pathways for Pyloric Stenosis

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Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G-protein signaling_H-RAS regulation pathway 22
10.89 GDNF RET
2
Signaling events regulated by Ret tyrosine kinase 1
10.74 GDNF RET
3
TRP channels 66
10.35 TRPC5 TRPC6
4
Muscular Dystrophies and Dystrophin-Glycoprotein Complex 64
9.9 DMD NOS1
5
RNAi Pathway 64
9.73 GDNF RET
Sources

GO Terms for Pyloric Stenosis

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Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 DMD RET SST TRPC5
2 cation channel complex GO:0034703 8.96 TRPC5 TRPC6
3 membrane raft GO:0045121 8.92 DMD NOS1 RET TRPC5

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.85 FOXF1 NKX2-5 NOS1 RET
2 positive regulation of cell proliferation GO:0008284 9.81 DMD GDNF NKX2-5 TRPC5
3 nervous system development GO:0007399 9.78 GDNF MBNL1 RET TRPC5
4 regulation of cytosolic calcium ion concentration GO:0051480 9.56 TRPC5 TRPC6
5 ureteric bud development GO:0001657 9.54 GDNF RET
6 regulation of cardiac conduction GO:1903779 9.52 NKX2-5 NOS1
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.49 TRPC5 TRPC6
8 peripheral nervous system development GO:0007422 9.46 GDNF NTF4
9 innervation GO:0060384 9.43 NTF4 RET
10 regulation of cardiac muscle contraction GO:0055117 9.4 NKX2-5 NOS1
11 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.37 DMD NOS1
12 enteric nervous system development GO:0048484 9.32 GDNF RET
13 manganese ion transport GO:0006828 9.26 TRPC5 TRPC6
14 neuron differentiation GO:0030182 9.26 DMD RET TRPC5 TRPC6
15 negative regulation of dendrite morphogenesis GO:0050774 9.16 TRPC5 TRPC6
16 positive regulation of neuron differentiation GO:0045666 8.92 DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin binding GO:0030276 9.26 TRPC5 TRPC6
2 inositol 1,4,5 trisphosphate binding GO:0070679 9.16 TRPC5 TRPC6
3 actinin binding GO:0042805 8.96 TRPC5 TRPC6
4 store-operated calcium channel activity GO:0015279 8.62 TRPC5 TRPC6
Sources

Sources for Pyloric Stenosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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