MCID: PYL006
MIFTS: 46

Pyloric Stenosis

Categories: Gastrointestinal diseases

Aliases & Classifications for Pyloric Stenosis

MalaCards integrated aliases for Pyloric Stenosis:

Name: Pyloric Stenosis 12 29 55 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12639
ICD10 33 K31.1
MeSH 44 D011707
NCIt 50 C34966
SNOMED-CT 68 367403001
UMLS 73 C0034194

Summaries for Pyloric Stenosis

MalaCards based summary : Pyloric Stenosis is related to hirschsprung disease 1 and hypertrophic pyloric stenosis. An important gene associated with Pyloric Stenosis is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Neuroscience and Signaling events regulated by Ret tyrosine kinase. The drugs Celecoxib and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Pyloric stenosis is a narrowing of the opening from the stomach to the first part of the small intestine... more...

Related Diseases for Pyloric Stenosis

Diseases related to Pyloric Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 hirschsprung disease 1 29.1 GDNF NOS1 NTRK3 RET
2 hypertrophic pyloric stenosis 28.2 DMD FOXF1 MBNL1 NKX2-5 NOS1 NTF4
3 pyloric stenosis, infantile hypertrophic, 1 12.5
4 pyloric stenosis, infantile hypertrophic, 5 12.2
5 pyloric stenosis, infantile hypertrophic, 4 12.1
6 pyloric stenosis, infantile hypertrophic, 2 12.1
7 pyloric stenosis, infantile hypertrophic, 3 12.1
8 intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome 12.0
9 acquired gastric outlet stenosis 11.8
10 duodenal atresia 11.1
11 congenital generalized lipodystrophy 11.1
12 epidermolysis bullosa junctionalis with pyloric atresia 11.1
13 type c thymoma 10.4 NTRK3 SST
14 medullary sponge kidney 10.3 GDNF RET
15 interatrial communication 10.3 DMD NKX2-5
16 esophagitis 10.3
17 hypoganglionosis 10.2 GDNF RET
18 aging 10.2
19 pylorospasm 10.2
20 ectopic cushing syndrome 10.2 RET SST
21 jejunoileitis 10.2 GDNF NOS1
22 multiple endocrine neoplasia, type iib 10.2 GDNF RET
23 gastric cancer 10.1
24 tracheoesophageal fistula with or without esophageal atresia 10.1
25 esophageal atresia 10.1
26 gastroenteritis 10.1
27 eosinophilic gastroenteritis 10.1
28 neuronitis 10.1
29 duodenitis 10.1
30 eosinophilic enteropathy 10.1
31 goldberg-shprintzen syndrome 10.0 GDNF RET
32 tetralogy of fallot 10.0 NKX2-5 NTRK3 RET
33 crohn's disease 10.0
34 mucositis 10.0
35 epidermolysis bullosa 10.0
36 tracheoesophageal fistula 10.0
37 colonic disease 10.0 GDNF RET
38 gilbert syndrome 10.0
39 ichthyosis, x-linked 10.0
40 pertussis 10.0
41 heart disease 10.0
42 pneumatosis cystoides intestinalis 10.0
43 ichthyosis 10.0
44 gastric dilatation 10.0
45 pancreatitis 10.0
46 gastroesophageal reflux 9.9
47 diaphragmatic hernia, congenital 9.9
48 jejunal atresia 9.9
49 myasthenia gravis 9.9
50 gastric ulcer 9.9

Graphical network of the top 20 diseases related to Pyloric Stenosis:



Diseases related to Pyloric Stenosis

Symptoms & Phenotypes for Pyloric Stenosis

MGI Mouse Phenotypes related to Pyloric Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.2 TRPC6 DMD GDNF HDC MBNL1 NOS1
2 cardiovascular system MP:0005385 10.09 DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
3 growth/size/body region MP:0005378 10.07 GDNF HDC MBNL1 NKX2-5 NOS1 NTF4
4 mortality/aging MP:0010768 10.02 DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
5 digestive/alimentary MP:0005381 9.95 NKX2-5 NOS1 RET SST DMD FOXF1
6 nervous system MP:0003631 9.93 DMD GDNF HDC MBNL1 NKX2-5 NOS1
7 muscle MP:0005369 9.86 DMD FOXF1 GDNF MBNL1 NKX2-5 NOS1
8 no phenotypic analysis MP:0003012 9.56 DMD HDC NKX2-5 NOS1 NTRK3 RET
9 respiratory system MP:0005388 9.1 NOS1 NTRK3 RET DMD FOXF1 NKX2-5

Drugs & Therapeutics for Pyloric Stenosis

Drugs for Pyloric Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
4
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
5
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
6 Analgesics Phase 4,Phase 3
7 Analgesics, Non-Narcotic Phase 4,Phase 3
8 Antacids Phase 4,Phase 3,Not Applicable
9 Anti-Inflammatory Agents Phase 4,Phase 3
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
11 Antirheumatic Agents Phase 4,Phase 3
12 Anti-Ulcer Agents Phase 4,Phase 3,Not Applicable
13 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
14 Cyclooxygenase Inhibitors Phase 4,Phase 3
15 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
16 Peripheral Nervous System Agents Phase 4,Phase 3
17 Proton Pump Inhibitors Phase 4,Phase 3,Not Applicable
18
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
19
Famotidine Approved Phase 3 76824-35-6 3325
20
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
21
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
22
Dexlansoprazole Approved, Investigational Phase 3 138530-94-6, 103577-45-3 9578005
23
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
24
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
25
Ticlopidine Approved Phase 3 55142-85-3 5472
26 Histamine Antagonists Phase 3
27 Histamine H2 Antagonists Phase 3
28
Histamine Phosphate Phase 3 51-74-1 65513
29 Neurotransmitter Agents Phase 3,Not Applicable
30 Antipyretics Phase 3
31 Fibrinolytic Agents Phase 3
32 Platelet Aggregation Inhibitors Phase 3
33 Anesthetics Phase 2, Phase 3
34 Cytochrome P-450 Enzyme Inhibitors Phase 3
35 Purinergic P2 Receptor Antagonists Phase 3
36 Purinergic P2Y Receptor Antagonists Phase 3
37
Acetaminophen Approved 103-90-2 1983
38
Azithromycin Approved Not Applicable 83905-01-5 55185 447043
39
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
40
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
41
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 119141-88-7 4594 9579578
42
Methylene blue Approved, Investigational Not Applicable 61-73-4
43
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
44
Epinephrine Approved, Vet_approved 51-43-4 5816
45
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
46
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
47
Racepinephrine Approved 329-65-7 838
48
Rocuronium Approved 119302-91-9, 143558-00-3 441290
49
Sevoflurane Approved, Vet_approved 28523-86-6 5206
50
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
2 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
3 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed NCT00141102 Phase 4 Celecoxib;Diclofenac + Omeprazole
4 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
5 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
6 Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis Completed NCT00195949 Phase 3
7 Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction Completed NCT01646476 Phase 3
8 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3 Ibuprofen/famotidine;Ibuprofen
9 Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers Completed NCT00450658 Phase 3 HZT-501;Ibuprofen
10 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3 Lansoprazole and naproxen and aspirin;Celecoxib and aspirin
11 Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy Recruiting NCT02784470 Phase 3
12 Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer Recruiting NCT02064803 Phase 3
13 Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial. Not yet recruiting NCT03223831 Phase 3
14 EUS - Guided Balloon-occluded Gastrojejunostomy Bypass Not yet recruiting NCT03223480 Phase 2, Phase 3
15 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
16 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
17 Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis Unknown status NCT00409734
18 The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents Unknown status NCT02440724 Not Applicable
19 The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood Unknown status NCT01159509
20 Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis Unknown status NCT00144924 Not Applicable
21 Biliary Drainage in Patients With Duodenal Metal Stent Unknown status NCT02376907
22 Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis Unknown status NCT02564965 Not Applicable
23 Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis Completed NCT01139853 Early Phase 1
24 Gastric Outlet Obstructions Tailored Covered Stents for GOO Completed NCT02299258 Not Applicable
25 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
26 ComVi and D-type Stent in Malignant GOO Completed NCT01839292 Not Applicable
27 Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy Completed NCT02359305 Acetaminophen;Acetaminophen
28 Different Feeding Methods After Pyloromyotomy Completed NCT01509417 Not Applicable
29 Covered Self-expandable Metallic Stents Insertion Using Clips and Suture Materials for Preventing Migration Completed NCT02193789 Not Applicable
30 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care
31 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
32 Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China Recruiting NCT03040817 Not Applicable Esomeprazole + Mosapride
33 Evaluation of the Efficacy of Duodenal Prostheses Not Covered Over 6 Years Recruiting NCT03463668
34 Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation (IRE) System Recruiting NCT02041936 Not Applicable
35 Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy Enrolling by invitation NCT02775214 Not Applicable
36 EUS-GE vs ES for Palliation of GOO Not yet recruiting NCT03259763 Not Applicable
37 Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia Not yet recruiting NCT02879292
38 Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study Not yet recruiting NCT03095144
39 Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction Terminated NCT00487552 Not Applicable
40 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Terminated NCT00753441 Not Applicable
41 Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer Withdrawn NCT01569282 Not Applicable

Search NIH Clinical Center for Pyloric Stenosis

Cochrane evidence based reviews: pyloric stenosis

Genetic Tests for Pyloric Stenosis

Genetic tests related to Pyloric Stenosis:

# Genetic test Affiliating Genes
1 Pyloric Stenosis 29

Anatomical Context for Pyloric Stenosis

MalaCards organs/tissues related to Pyloric Stenosis:

41
Small Intestine, Pancreas, Heart, Kidney, Liver, Smooth Muscle, Testes

Publications for Pyloric Stenosis

Articles related to Pyloric Stenosis:

(show top 50) (show all 829)
# Title Authors Year
1
Perioperative Complications of Surgery for Hypertrophic Pyloric Stenosis. ( 29510427 )
2018
2
The incidence of infantile hypertrophic pyloric stenosis and its association with folic acid supplementation during pregnancy: A nested case-control study. ( 29884554 )
2018
3
Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon. ( 29338765 )
2018
4
Placement of a lumen-apposing metal stent for palliation of malignant pyloric stenosis. ( 29895067 )
2018
5
Pyloric stenosis: an enigma more than a century after the first successful treatment. ( 29030700 )
2018
6
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
7
Adult idiopathic hypertrophic pyloric stenosis - a common presentation with an uncommon diagnosis. ( 29686790 )
2018
8
Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a survey of 407 children. ( 29411105 )
2018
9
Current perioperative care of infants with pyloric stenosis: comparison of survey results. ( 29157882 )
2018
10
Case of hepatic portal venous gas in an infant with hypertrophic pyloric stenosis. ( 29980514 )
2018
11
Palliation of Malignant Pyloric Stenosis Using a Lumen-Apposing Metal Stent. ( 29609066 )
2018
12
Postoperative outcomes of open versus laparoscopic pyloromyotomy for hypertrophic pyloric stenosis. ( 29506847 )
2018
13
Transient neonatal myasthenia gravis with infantile hypertrophic pyloric stenosis: coincidence or causation? ( 29099348 )
2017
14
The treatment of pyloric stenosis: Evolution in practice. ( 29148193 )
2017
15
Epidemiological and clinical characteristics of 304 patients with infantile hypertrophic pyloric stenosis in Anhui Province of East China, 2012-2015. ( 28701060 )
2017
16
Atropine Treatment for Hypertrophic Pyloric Stenosis: A Systematic Review and Meta-analysis. ( 28701002 )
2017
17
50 Years Ago in The Journal of Pediatrics: The Radiographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis. ( 28648281 )
2017
18
Caterpillar Sign in Infantile Hypertrophic Pyloric Stenosis. ( 29236645 )
2017
19
A breathtakingly rare presentation of pyloric stenosis. ( 28665094 )
2017
20
Excessive Bright Echoes Sign for Hypertrophic Pyloric Stenosis Suggest the Diagnosis: Gastric Pneumatosis and Portal Venous Gas in Infants Suggest HPS. ( 28295432 )
2017
21
Corrected to uncorrected? The metabolic conundrum of hypertrophic pyloric stenosis. ( 28189444 )
2017
22
Population-level surgical outcomes for infantile hypertrophic pyloric stenosis. ( 28576429 )
2017
23
Use of a lumen-apposing metal stent to treat pyloric stenosis. ( 28389214 )
2017
24
Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. ( 28318599 )
2017
25
Application of color Doppler ultrasound combined with Doppler imaging artifacts in the diagnosis and estimate of congenital hypertrophic pyloric stenosis. ( 28842652 )
2017
26
Consideration of pyloric stenosis as a cause of feeding dysfunction in children with cyanotic heart disease. ( 28928620 )
2017
27
A Difficult Recurrent Hypertrophic Pyloric Stenosis. ( 28770145 )
2017
28
Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis? ( 28550912 )
2017
29
Immediate Emergency Department Diagnosis of Pyloric Stenosis with Point-of-care Ultrasound. ( 29849342 )
2017
30
Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature. ( 27642452 )
2016
31
Adult-Onset Idiopathic Hypertrophic Pyloric Stenosis Associated With Osteoglophonic Dysplasia and HIV: Case Report and Review of Literature. ( 27599310 )
2016
32
No association between macrolide treatment in infancy and later pyloric stenosis in Sweden. ( 26694588 )
2016
33
Efficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: AA Meta-analysis. ( 27215474 )
2016
34
Prematurity Affects Age of Presentation of Pyloric Stenosis. ( 27149987 )
2016
35
Hypertrophic pyloric stenosis in the Maritimes: examining the waves of change over time. ( 27669400 )
2016
36
Gastric adenomyoma clinically simulating hypertrophic pyloric stenosis. ( 26837724 )
2016
37
Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease. ( 27528563 )
2016
38
Optimizing fluid resuscitation in hypertrophic pyloric stenosis. ( 26876090 )
2016
39
Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. ( 27506212 )
2016
40
Recurrent pyloric stenosis. ( 27389044 )
2016
41
Adult idiopathic hypertrophic pyloric stenosis. ( 27362602 )
2016
42
Pitfall in the remote imaging of pyloric stenosis. ( 27260853 )
2016
43
Cost of Hospitalization for Infantile Pyloric Stenosis. ( 26802838 )
2016
44
Health disparities in infants with hypertrophic pyloric stenosis. ( 27586849 )
2016
45
Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis. ( 27292596 )
2016
46
Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. ( 27655365 )
2016
47
Is there any correlation between radiologic findings and eradication of symptoms after pyloromyotomy in hypertrophic pyloric stenosis? ( 27251656 )
2016
48
A randomized trial to assess advancement of enteral feedings following surgery for hypertrophic pyloric stenosis. ( 27829521 )
2016
49
Idiopathic pyloric stenosis. ( 28154715 )
2016
50
Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. ( 26944185 )
2016

Variations for Pyloric Stenosis

ClinVar genetic disease variations for Pyloric Stenosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(2;13)(p25.2;q31.3)dn Translocation Uncertain significance
2 CHD7 NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter) single nucleotide variant Likely pathogenic rs367557471 GRCh37 Chromosome 8, 61734614: 61734614
3 CHD7 NM_017780.3(CHD7): c.2867C> A (p.Ser956Ter) single nucleotide variant Likely pathogenic rs367557471 GRCh38 Chromosome 8, 60822055: 60822055

Expression for Pyloric Stenosis

Search GEO for disease gene expression data for Pyloric Stenosis.

Pathways for Pyloric Stenosis

Pathways related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 NOS1 NTRK3 RET TRPC6
2 10.84 GDNF RET
3 10.55 TRPC5 TRPC6
4 10.23 DMD NOS1

GO Terms for Pyloric Stenosis

Cellular components related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 DMD RET SST TRPC5
2 axon GO:0030424 9.26 DMD NTF4 NTRK3 RET
3 membrane raft GO:0045121 8.92 DMD NOS1 RET TRPC5

Biological processes related to Pyloric Stenosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.93 DMD FOXF1 NKX2-5 NTRK3 RET
2 negative regulation of apoptotic process GO:0043066 9.87 GDNF NKX2-5 NTRK3 RET
3 positive regulation of cell migration GO:0030335 9.73 FOXF1 NTRK3 RET
4 nervous system development GO:0007399 9.72 GDNF MBNL1 NTRK3 RET TRPC5
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.65 NTF4 NTRK3 RET
6 positive regulation of cell proliferation GO:0008284 9.65 DMD GDNF NKX2-5 NTRK3 TRPC5
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.55 TRPC5 TRPC6
8 peripheral nervous system development GO:0007422 9.52 GDNF NTF4
9 regulation of cardiac muscle contraction GO:0055117 9.51 NKX2-5 NOS1
10 innervation GO:0060384 9.49 NTF4 RET
11 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.46 DMD NOS1
12 enteric nervous system development GO:0048484 9.43 GDNF RET
13 manganese ion transport GO:0006828 9.4 TRPC5 TRPC6
14 negative regulation of dendrite morphogenesis GO:0050774 9.37 TRPC5 TRPC6
15 neuron differentiation GO:0030182 9.26 DMD RET TRPC5 TRPC6
16 mechanoreceptor differentiation GO:0042490 9.16 NTF4 NTRK3
17 positive regulation of neuron differentiation GO:0045666 8.92 DMD NKX2-5 TRPC5 TRPC6

Molecular functions related to Pyloric Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inositol 1,4,5 trisphosphate binding GO:0070679 9.16 TRPC5 TRPC6
2 actinin binding GO:0042805 8.96 TRPC5 TRPC6
3 store-operated calcium channel activity GO:0015279 8.62 TRPC5 TRPC6

Sources for Pyloric Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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