MCID: PYL002
MIFTS: 31

Pylorospasm

Categories: Gastrointestinal diseases

Aliases & Classifications for Pylorospasm

MalaCards integrated aliases for Pylorospasm:

Name: Pylorospasm 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12072
ICD9CM 35 537.81
SNOMED-CT 68 335002
ICD10 33 K31.3
UMLS 73 C0152163

Summaries for Pylorospasm

MalaCards based summary : Pylorospasm is related to gastroparesis and gastroesophageal reflux, and has symptoms including dyspepsia, spasm and gastric irritation. An important gene associated with Pylorospasm is SST (Somatostatin). Affiliated tissues include colon, pituitary and pancreas.

Related Diseases for Pylorospasm

Diseases related to Pylorospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 gastroparesis 29.7 GAST GHRL MLN
2 gastroesophageal reflux 29.7 GAST GHRL MLN
3 pyloric stenosis 10.6
4 hypertrophic pyloric stenosis 10.4
5 ectopic cushing syndrome 10.2 GHRL SST
6 dyspepsia 10.1 GHRL SST
7 hyperhidrosis, gustatory 10.1 HCK KANTR
8 pituitary-dependent cushing's disease 10.1 HTR4 SST
9 hemometra 10.1 HCK KANTR
10 functional diarrhea 10.1 GHRL HTR4
11 paralytic squint 10.1 HCK KANTR
12 glucose metabolism disease 10.1 GHRL SST
13 acquired metabolic disease 10.1 GHRL SST
14 acromegaly 10.0 GHRL SST
15 gastrointestinal neuroendocrine benign tumor 10.0 GAST SST
16 gastric neuroendocrine neoplasm 10.0 GAST SST
17 insulinomatosis and diabetes mellitus 10.0 GAST SST
18 vipoma 10.0 GAST SST
19 retinitis pigmentosa 40 10.0 GAST SST
20 pancreatic cholera 10.0 GAST SST
21 pernicious anemia 10.0 GAST SST
22 duodenal gastrinoma 10.0 GAST SST
23 gastrinoma 10.0 GAST SST
24 gastritis 10.0 GAST GHRL
25 zollinger-ellison syndrome 10.0 GAST SST
26 gallbladder disease 10.0 MLN SST
27 hyperthyroidism 10.0 GHRL SST
28 mixed ductal-endocrine carcinoma 10.0 GAST SST
29 ileum cancer 10.0 GAST SST
30 non-functioning pancreatic endocrine tumor 10.0 GAST GHRL
31 islet cell tumor 10.0 GAST SST
32 gastrointestinal system benign neoplasm 10.0 GAST SST
33 serotonin syndrome 10.0 GAST SST
34 functional gastric disease 10.0 GHRL MLN SST
35 irritable bowel syndrome 10.0 HTR4 MLN
36 duodenal ulcer 9.9 GAST SST
37 pancreas disease 9.9 GAST SST
38 mucinous ovarian cystadenoma 9.9 GAST MUC5AC
39 peptic ulcer disease 9.9 GAST GHRL
40 blind loop syndrome 9.9 GHRL HTR4 MLN
41 esophageal disease 9.9 GAST KANTR
42 atrophic gastritis 9.9 GAST GHRL SST
43 space motion sickness 9.9 GAST MLN
44 duodenogastric reflux 9.8 GAST MLN SST
45 multiple endocrine neoplasia, type i 9.8 GAST SST
46 functional colonic disease 9.7 HTR4 KANTR MLN SST
47 colonic pseudo-obstruction 9.7 HTR4 KANTR MLN SST
48 constipation 9.6 GAST HTR4 MLN SST
49 postcholecystectomy syndrome 9.6 GAST KANTR MLN SST
50 gastrointestinal system disease 9.5 GAST GHRL HTR4 MLN SST

Comorbidity relations with Pylorospasm via Phenotypic Disease Network (PDN):


Esophagitis

Graphical network of the top 20 diseases related to Pylorospasm:



Diseases related to Pylorospasm

Symptoms & Phenotypes for Pylorospasm

UMLS symptoms related to Pylorospasm:


dyspepsia, spasm, gastric irritation, upset stomach

Drugs & Therapeutics for Pylorospasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119

Search NIH Clinical Center for Pylorospasm

Genetic Tests for Pylorospasm

Anatomical Context for Pylorospasm

MalaCards organs/tissues related to Pylorospasm:

41
Colon, Pituitary, Pancreas, Thyroid

Publications for Pylorospasm

Articles related to Pylorospasm:

(show all 32)
# Title Authors Year
1
Formulation development and evaluation of nifedipine as pylorospasm inhibitor. ( 29429379 )
2018
2
Gastric per oral endoscopic myotomy (G-POEM) for pylorospasm: case report and literature review. ( 28727260 )
2017
3
Methicillin-Resistant Staphylococcus aureus Subhepatic Abscess Presenting as Pylorospasm in a Neonate. ( 26835566 )
2016
4
Lacidipine encapsulated gastroretentive microspheres prepared by chemical denaturation for pylorospasm. ( 18720200 )
2009
5
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. ( 18528245 )
2008
6
Is pylorospasm a cause of delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? ( 15827814 )
2005
7
The sonographic double-track sign: not pathognomonic for hypertrophic pyloric stenosis; can be seen in pylorospasm. ( 15154530 )
2004
8
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. ( 9805307 )
1998
9
Short segment pyloric narrowing. Pylorospasm or pyloric stenosis? ( 7254915 )
1981
10
Electromyographic studies on the mechanism of pylorospasm following vagotomy. ( 5529947 )
1970
11
The value of the double-track sign as a differentiating factor between pylorospasm and hypertrophic pyloric stenosis in infants. ( 5934325 )
1966
12
USE OF CARBON DIOXIDE INHALATION IN PYLOROSPASM. PRELIMINARY REPORT. ( 14074369 )
1963
13
The use of meclizine dihydrochloride with pyridoxine in vomiting and pylorospasm in infants and children. ( 13355514 )
1956
14
The histopathologic changes in the myenteric plexus of the pylorus in hypertrophic pyloric stenosis of infants (pylorospasm). ( 13361866 )
1956
15
An oral therapy (bonadoxin drops) for infant colic and pylorospasm. ( 13319913 )
1956
16
Management with procaine amide (pronestyl) of pylorospasm in infants. ( 13151845 )
1954
17
The use of banthine bromide in infantile pylorospasm; report of nine cases with x-ray study. ( 13053368 )
1953
18
Treatment of vagotomy-induced chronic pylorospasm in dogs. ( 14860399 )
1951
19
Treatment of pylorospasm and allied conditions with spasmo cibalgine. ( 18126814 )
1949
20
The incidence of pylorospasm and pyloric stenosis among vomiters in Egyptian infants. ( 18126811 )
1949
21
Pylorospasm in the adult, complicated by uraemia. ( 18210501 )
1949
22
Pyloric stenosis and pylorospasm. ( 18118033 )
1949
23
Pyloric stenosis following pylorospasm. ( 18934574 )
1948
24
Pylorospasm. ( 18934573 )
1948
25
Spontaneous pylorospasm in rabbits. ( 20249443 )
1947
26
The alleviation of pylorospasm and colic in infants by reducing the volume of the food intake per feeding. ( 20285600 )
1946
27
EVIDENCE THAT BODY IRRITATIONS OR EMOTIONS RETARD GASTRIC EVACUATION, NOT BY PRODUCING PYLOROSPASM BUT BY DEPRESSING GASTRIC MOTILITY. ( 16695068 )
1943
28
EXPERIMENTAL PRODUCTION OF PYLOROSPASM AND GASTRIC RETENTION IN RATS. ( 19870149 )
1933
29
THE SURGERY OF PYLOROSPASM. ( 17866174 )
1929
30
DIVISION OF THE VAGI FOR PYLOROSPASM. ( 17865978 )
1928
31
Case of Pyloric Stenosis (Pylorospasm). ( 19985323 )
1926
32
The Radiological Investigation of Infantile Pyloric Stenosis and Pylorospasm. ( 19984348 )
1925

Variations for Pylorospasm

Expression for Pylorospasm

Search GEO for disease gene expression data for Pylorospasm.

Pathways for Pylorospasm

GO Terms for Pylorospasm

Biological processes related to Pylorospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.35 GAST GHRL HTR4 MLN SST
2 regulation of signaling receptor activity GO:0010469 8.92 GAST GHRL MLN SST

Molecular functions related to Pylorospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GAST GHRL MLN SST

Sources for Pylorospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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