MCID: PYL002
MIFTS: 24

Pylorospasm

Categories: Gastrointestinal diseases

Aliases & Classifications for Pylorospasm

MalaCards integrated aliases for Pylorospasm:

Name: Pylorospasm 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12072
ICD9CM 35 537.81
SNOMED-CT 68 335002
ICD10 33 K31.3
UMLS 73 C0152163

Summaries for Pylorospasm

MalaCards based summary : Pylorospasm is related to gastroparesis and gastroesophageal reflux, and has symptoms including dyspepsia, spasm and upset stomach. An important gene associated with Pylorospasm is SST (Somatostatin).

Related Diseases for Pylorospasm

Diseases related to Pylorospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 gastroparesis 28.7 GAST GHRL MLN
2 gastroesophageal reflux 28.7 GAST GHRL MLN
3 ectopic cushing syndrome 10.5 GHRL SST
4 hyperhidrosis, gustatory 10.5 HCK KANTR
5 adrenal gland hyperfunction 10.5 GHRL SST
6 dyspepsia 10.4 GHRL SST
7 hemometra 10.4 HCK KANTR
8 pyloric stenosis 10.4
9 paralytic squint 10.4 HCK KANTR
10 glucose metabolism disease 10.3 GHRL SST
11 pituitary-dependent cushing's disease 10.3 HTR4 SST
12 functional diarrhea 10.3 GHRL HTR4
13 acquired metabolic disease 10.2 GHRL SST
14 hypertrophic pyloric stenosis 10.2
15 acromegaly 10.2 GHRL SST
16 intestinal disease 10.1 GHRL HTR4
17 hyperthyroidism 10.1 GHRL SST
18 gallbladder disease 10.1 MLN SST
19 gastrointestinal neuroendocrine benign tumor 10.1 GAST SST
20 gastric neuroendocrine neoplasm 10.1 GAST SST
21 hyperinsulinemic hypoglycemia, familial, 2 10.1 GAST SST
22 vipoma 10.1 GAST SST
23 retinitis pigmentosa 40 10.1 GAST SST
24 pancreatic cholera 10.0 GAST SST
25 pernicious anemia 10.0 GAST SST
26 duodenal gastrinoma 10.0 GAST SST
27 zollinger-ellison syndrome 10.0 GAST SST
28 gastrinoma 10.0 GAST SST
29 mixed ductal-endocrine carcinoma 10.0 GAST SST
30 islet cell tumor 10.0 GAST SST
31 non-functioning pancreatic endocrine tumor 10.0 GAST GHRL
32 serotonin syndrome 9.9 GAST SST
33 functional gastric disease 9.9 GHRL MLN SST
34 duodenal ulcer 9.9 GAST SST
35 irritable bowel syndrome 9.9 HTR4 MLN
36 depression 9.9
37 peptic ulcer disease 9.8 GAST GHRL
38 mucinous ovarian cystadenoma 9.8 GAST MUC5AC
39 esophageal disease 9.8 GAST KANTR
40 endocrine gland cancer 9.8 GAST SST
41 atrophic gastritis 9.6 GAST GHRL SST
42 gastritis 9.4 GAST GHRL
43 duodenogastric reflux 9.4 GAST MLN SST
44 multiple endocrine neoplasia, type i 9.2 GAST SST
45 functional colonic disease 9.2 HTR4 KANTR MLN SST
46 colonic pseudo-obstruction 9.2 HTR4 KANTR MLN SST
47 postcholecystectomy syndrome 8.8 GAST KANTR MLN SST
48 constipation 8.7 GAST HTR4 MLN SST
49 stomach disease 8.3 GAST GHRL HTR4 MLN SST
50 gastrointestinal system disease 8.3 GAST GHRL HTR4 MLN SST

Comorbidity relations with Pylorospasm via Phenotypic Disease Network (PDN):


Esophagitis

Graphical network of the top 20 diseases related to Pylorospasm:



Diseases related to Pylorospasm

Symptoms & Phenotypes for Pylorospasm

UMLS symptoms related to Pylorospasm:


dyspepsia, spasm, upset stomach, gastric irritation

Drugs & Therapeutics for Pylorospasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119

Search NIH Clinical Center for Pylorospasm

Genetic Tests for Pylorospasm

Anatomical Context for Pylorospasm

Publications for Pylorospasm

Articles related to Pylorospasm:

(show all 32)
# Title Authors Year
1
Formulation development and evaluation of nifedipine as pylorospasm inhibitor. ( 29429379 )
2018
2
Gastric per oral endoscopic myotomy (G-POEM) for pylorospasm: case report and literature review. ( 28727260 )
2017
3
Methicillin-Resistant Staphylococcus aureus Subhepatic Abscess Presenting as Pylorospasm in a Neonate. ( 26835566 )
2016
4
Lacidipine encapsulated gastroretentive microspheres prepared by chemical denaturation for pylorospasm. ( 18720200 )
2009
5
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. ( 18528245 )
2008
6
Is pylorospasm a cause of delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? ( 15827814 )
2005
7
The sonographic double-track sign: not pathognomonic for hypertrophic pyloric stenosis; can be seen in pylorospasm. ( 15154530 )
2004
8
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. ( 9805307 )
1998
9
Short segment pyloric narrowing. Pylorospasm or pyloric stenosis? ( 7254915 )
1981
10
Electromyographic studies on the mechanism of pylorospasm following vagotomy. ( 5529947 )
1970
11
The value of the double-track sign as a differentiating factor between pylorospasm and hypertrophic pyloric stenosis in infants. ( 5934325 )
1966
12
USE OF CARBON DIOXIDE INHALATION IN PYLOROSPASM. PRELIMINARY REPORT. ( 14074369 )
1963
13
The use of meclizine dihydrochloride with pyridoxine in vomiting and pylorospasm in infants and children. ( 13355514 )
1956
14
The histopathologic changes in the myenteric plexus of the pylorus in hypertrophic pyloric stenosis of infants (pylorospasm). ( 13361866 )
1956
15
An oral therapy (bonadoxin drops) for infant colic and pylorospasm. ( 13319913 )
1956
16
Management with procaine amide (pronestyl) of pylorospasm in infants. ( 13151845 )
1954
17
The use of banthine bromide in infantile pylorospasm; report of nine cases with x-ray study. ( 13053368 )
1953
18
Treatment of vagotomy-induced chronic pylorospasm in dogs. ( 14860399 )
1951
19
Treatment of pylorospasm and allied conditions with spasmo cibalgine. ( 18126814 )
1949
20
The incidence of pylorospasm and pyloric stenosis among vomiters in Egyptian infants. ( 18126811 )
1949
21
Pylorospasm in the adult, complicated by uraemia. ( 18210501 )
1949
22
Pyloric stenosis and pylorospasm. ( 18118033 )
1949
23
Pyloric stenosis following pylorospasm. ( 18934574 )
1948
24
Pylorospasm. ( 18934573 )
1948
25
Spontaneous pylorospasm in rabbits. ( 20249443 )
1947
26
The alleviation of pylorospasm and colic in infants by reducing the volume of the food intake per feeding. ( 20285600 )
1946
27
EVIDENCE THAT BODY IRRITATIONS OR EMOTIONS RETARD GASTRIC EVACUATION, NOT BY PRODUCING PYLOROSPASM BUT BY DEPRESSING GASTRIC MOTILITY. ( 16695068 )
1943
28
EXPERIMENTAL PRODUCTION OF PYLOROSPASM AND GASTRIC RETENTION IN RATS. ( 19870149 )
1933
29
THE SURGERY OF PYLOROSPASM. ( 17866174 )
1929
30
DIVISION OF THE VAGI FOR PYLOROSPASM. ( 17865978 )
1928
31
Case of Pyloric Stenosis (Pylorospasm). ( 19985323 )
1926
32
The Radiological Investigation of Infantile Pyloric Stenosis and Pylorospasm. ( 19984348 )
1925

Variations for Pylorospasm

Expression for Pylorospasm

Search GEO for disease gene expression data for Pylorospasm.

Pathways for Pylorospasm

GO Terms for Pylorospasm

Biological processes related to Pylorospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.35 GAST GHRL HTR4 MLN SST
2 regulation of signaling receptor activity GO:0010469 8.92 GAST GHRL MLN SST

Molecular functions related to Pylorospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GAST GHRL MLN SST

Sources for Pylorospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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