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MCID: PYL002
MIFTS: 27

Pylorospasm

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pylorospasm

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MalaCards integrated aliases for Pylorospasm:

Name: Pylorospasm 12 15 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:12072
ICD9CM 34 537.81
SNOMED-CT 67 335002
ICD10 32 K31.3
UMLS 71 C0152163
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Summaries for Pylorospasm

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MalaCards based summary : Pylorospasm is related to gastroparesis and pyloric stenosis, and has symptoms including dyspepsia, spasm and gastric irritation. An important gene associated with Pylorospasm is MLN (Motilin), and among its related pathways/superpathways is Semaphorin Signaling. The drugs Metoclopramide and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include small intestine and testes.

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Related Diseases for Pylorospasm

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Diseases related to Pylorospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 gastroparesis 30.4 MLNR MLN
2 pyloric stenosis 10.7
3 hypertrophic pyloric stenosis 10.6
4 cascade stomach 10.4
5 functional colonic disease 10.2 MLNR MLN
6 colonic pseudo-obstruction 10.2 MLNR MLN
7 functional gastric disease 10.2 MLNR MLN
8 gastroesophageal reflux 10.1
9 volvulus of midgut 10.1
10 anorexia nervosa 10.1
11 muscle hypertrophy 10.1
12 villous adenoma 10.1
13 acute cystitis 10.1
14 ileus 10.1
15 diabetic autonomic neuropathy 10.1 MLNR MLN
16 autonomic neuropathy 10.1 MLNR MLN
17 intestinal obstruction 9.9 MLNR MLN
18 optic nerve neoplasm 9.9 RASA2 LZTR1
19 stomach disease 9.8 MLNR MLN
20 neurofibromatosis-noonan syndrome 9.6 SOS2 A2ML1
21 juvenile myelomonocytic leukemia 9.2 SOS2 RASA2 LZTR1
22 pulmonary valve disease 9.0 SOS2 RASA2 LZTR1 A2ML1
23 pulmonary valve stenosis 9.0 SOS2 RASA2 LZTR1 A2ML1
24 noonan syndrome with multiple lentigines 9.0 SOS2 RASA2 LZTR1 A2ML1
25 cardiofaciocutaneous syndrome 1 9.0 SOS2 RASA2 LZTR1 A2ML1
26 noonan syndrome 1 8.9 SOS2 RASA2 LZTR1 A2ML1

Comorbidity relations with Pylorospasm via Phenotypic Disease Network (PDN):


Esophagitis

Graphical network of the top 20 diseases related to Pylorospasm:



Diseases related to Pylorospasm
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Symptoms & Phenotypes for Pylorospasm

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UMLS symptoms related to Pylorospasm:


dyspepsia, spasm, gastric irritation, upset stomach
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Drugs & Therapeutics for Pylorospasm

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Drugs for Pylorospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
2
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
3 Neurotransmitter Agents Phase 2
4 Dopamine Antagonists Phase 2
5 Pharmaceutical Solutions Phase 2
6 Antiemetics Phase 2
7 Dopamine Agents Phase 2
8 Gastrointestinal Agents Phase 2
9
Acetylcholine Approved, Investigational 51-84-3 187
10 abobotulinumtoxinA
11 Cholinergic Agents
12 Botulinum Toxins, Type A
13 Botulinum Toxins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial of Metoclopramide Versus Placebo During Gastrojejunostomy Tube Placement for Facilitating Guidewire Advancement Through the Pylorus Completed NCT03331965 Phase 2 Metoclopramide 5 MG/ML Injectable Solution;Saline
2 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119
3 Randomized Placebo-Controlled Double Blind Study of Botulinum Toxin Versus Placebo for the Treatment of Gastroparesis Completed NCT00372970 Botulinum toxin A;Placebo
4 Transpyloric Stenting for Refractory Gastroparesis Prior to Gastric Per-Oral Endoscopic Myotomy: A Prospective Sham Study Recruiting NCT04287647
5 A Randomized, Sham and Cross-Over-Controlled Trial of Per-oral Endoscopic Pyloromyotomy (G-POEM) in Patients With Refractory Gastroparesis Recruiting NCT03356067

Search NIH Clinical Center for Pylorospasm

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Genetic Tests for Pylorospasm

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Anatomical Context for Pylorospasm

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MalaCards organs/tissues related to Pylorospasm:

40
Small Intestine, Testes
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Publications for Pylorospasm

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Articles related to Pylorospasm:

(show top 50) (show all 116)
# Title Authors PMID Year
1
Pyloric distensibility measurement after gastric surgery: Which surgeries are associated with pylorospasm? 61
31916346 2020
2
An ileo-ileal intussusception secondary to polypoid lipoma in a child, a case report and review of the literature. 61
30927709 2019
3
Stent Placement for the Treatment of Gastroparesis. 61
30396520 2019
4
State of the art review with literature summary on gastric peroral endoscopic pyloromyotomy for gastroparesis. 61
29806114 2018
5
Formulation development and evaluation of nifedipine as pylorospasm inhibitor. 61
29429379 2018
6
Gastric peroral endoscopic myotomy for pylorospasm: Case report and literature review. 61
28727260 2017
7
Synchronous perforations of the oesophagus and stomach by air insufflation: an uncommon complication of endoscopic dilation. 61
27799228 2016
8
Novel Diet, Drugs, and Gastric Interventions for Gastroparesis. 61
26762845 2016
9
Peroral endoscopic pyloromyotomy accelerates gastric emptying in healthy pigs: proof of concept. 61
27556100 2016
10
Methicillin-Resistant Staphylococcus aureus Subhepatic Abscess Presenting as Pylorospasm in a Neonate. 61
26835566 2016
11
Diabetic gastroparesis. 61
25667022 2015
12
Lacidipine encapsulated gastroretentive microspheres prepared by chemical denaturation for pylorospasm. 61
18720200 2009
13
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. 61
18528245 2008
14
[Gastroesophageal reflux in children]. 61
17601041 2007
15
Minimally invasive esophagectomy for cancer: prospective evaluation of laparoscopic gastric mobilization. 61
16850150 2006
16
Delayed gastric emptying: whom to test, how to test, and what to do. 61
16836948 2006
17
[Minimally invasive esophagectomy: prospective evaluation of laparoscopic gastric mobilization]. 61
16466684 2006
18
Is pylorospasm a cause of delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? 61
15827814 2005
19
Real time high resolution magnetic resonance imaging for the assessment of gastric motility disorders. 61
15306580 2004
20
Delayed salicylate toxicity at 35 hours without early manifestations following a single salicylate ingestion. 61
15173556 2004
21
The sonographic double-track sign: not pathognomonic for hypertrophic pyloric stenosis; can be seen in pylorospasm. 61
15154530 2004
22
Gastroparesis and neuromuscular disorders of the stomach. 61
16481977 2003
23
Congenital hypertrophic pyloric stenosis. 61
12356225 2002
24
Gastrin, somatostatin and infantile hypertrophic pyloric stenosis. 61
11529535 2001
25
Thoracoscopic truncal vagotomy. 61
11232981 2000
26
Botulinum toxin for spastic gastrointestinal disorders. 61
11030639 1999
27
[Omentoplasty in surgical management of postpulmonectomy pleural empyema]. 61
11484240 1999
28
[Suprapyloric resection of stomach in patients with ulcer disease]. 61
10050505 1999
29
Ultrasonography of pylorospasm: findings may simulate hypertrophic pyloric stenosis. 61
9805307 1998
30
Effects of octreotide on manometric variables in patients with neuropathic abnormalities of the small bowel. 61
9286228 1997
31
[Functional, organic and histologic changes in the stomach in diabetic patients in relation to the presence of diabetic neuropathy]. 61
9019625 1996
32
Hypertrophic pyloric stenosis in the infant without a palpable olive: accuracy of sonographic diagnosis. 61
7972822 1994
33
Gastric retention of enteric-coated magnesium chloride tablets. 61
7949504 1994
34
[Clinical studies of intra-thoracic stomach function in patients after esophagectomy and reconstruction by whole stomach]. 61
8223003 1993
35
[The late examination results in children with pylorospasm and dyskinesia of the proximal sections of the small intestine]. 61
1294794 1992
36
Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis. 61
1378938 1992
37
[Balloon dilatation of benign esophageal stenoses]. 61
1849292 1991
38
[Surgical treatment of gastroesophageal reflux by modified Hill's posterior cardiopexy. Apropos of 441 cases]. 61
2100119 1990
39
Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. 61
2914260 1989
40
[A new method of differential diagnosis and treatment of pyloric spasm]. 61
2797837 1989
41
Valvuloplasty plus fundoplasty to prevent esophageal regurgitation in esophagogastrostomy after proximal gastrectomy. 61
3752383 1986
42
Pyloric dysfunction in diabetics with recurrent nausea and vomiting. 61
3699409 1986
43
Gastric damage from ingested acid in children. 61
4057013 1985
44
Symptomatic gastroduodenal pancreatic rest in children. 61
6481592 1984
45
Effects of rociverine and other spasmolytic agents on caerulein-induced delay in gastric emptying in the conscious rat. 61
7114969 1982
46
Radiographic abnormalities after gastric bypass. 61
6976728 1982
47
Short segment pyloric narrowing. Pylorospasm or pyloric stenosis? 61
7254915 1981
48
Peptic ulcer disease in early infancy: clinical presentation and roentgenographic features. 61
7211360 1980
49
Diagnostic advantages of manual compression fluoroscopy in the radiologic work-up of vomiting neonates. 61
7381660 1980
50
Patterns of postcibal gastroesophageal reflux in symptomatic infants. 61
41457 1979
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Variations for Pylorospasm

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Expression for Pylorospasm

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Search GEO for disease gene expression data for Pylorospasm.
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Pathways for Pylorospasm

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Pathways related to Pylorospasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Semaphorin Signaling 63
10.28 SOS2 RASA2
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GO Terms for Pylorospasm

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Biological processes related to Pylorospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of Ras protein signal transduction GO:0046580 8.62 RASA2 LZTR1
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Sources for Pylorospasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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