MCID: PYD002
MIFTS: 51

Pyoderma

Categories: Skin diseases
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Aliases & Classifications for Pyoderma

MalaCards integrated aliases for Pyoderma:

Name: Pyoderma 11 53 43 14 71 75 31

Classifications:



External Ids:

Disease Ontology 11 DOID:4223
ICD9CM 34 686.0
MeSH 43 D011711
SNOMED-CT 68 267838007
ICD10 31 L08.0
UMLS 71 C0034212

Summaries for Pyoderma

Disease Ontology: 11 A dermatitis that is characterized by a pyogenic infection causing the formation of pus.

MalaCards based summary: Pyoderma is related to crohn's disease and neutrophilic dermatosis, acute febrile, and has symptoms including pruritus, exanthema and pustular rash. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Akt Signaling. The drugs Anti-Inflammatory Agents and Endothelial Growth Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and breast, and related phenotypes are immune system and neoplasm

Wikipedia: 75 Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial... more...

Related Diseases for Pyoderma

Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 893)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 31.9 TNF NOD2 CXCL8 CCR6
2 neutrophilic dermatosis, acute febrile 31.9 TNF PSTPIP1 MEFV CXCL8 CSF3
3 inflammatory bowel disease 1 31.6 TNF NOD2 CCR6
4 pyoderma gangrenosum 31.5 TNF PSTPIP1 NOD2 MMP9 MMP26 MMP10
5 ulcerative colitis 31.4 TNF NOD2 IL1R1 CXCL8 CCR6
6 hidradenitis 31.3 TNF PSTPIP1 NOD2 MEFV
7 hidradenitis suppurativa 31.3 TNF PSTPIP1 NOD2 MEFV
8 acne 31.2 TNF PSTPIP1 MMP1 MEFV CXCL8
9 colitis 31.2 TNF NOD2 IL1R1 CXCL8 CCR6
10 vasculitis 31.0 TNF MEFV ITGB2 IFNA2 CXCL8 APOH
11 erythema nodosum 31.0 TNF NOD2 CXCL8
12 dermatitis 31.0 TNF NOD2 CXCL8 CCR6
13 fasciitis 30.9 TNF MYOM2 MMP1 CXCL8
14 necrotizing fasciitis 30.9 TNF MYOM2 F3 CXCL8
15 myelodysplastic syndrome 30.9 TNF IFNA2 CXCL8 CSF3 CCR6
16 myelofibrosis 30.8 TNF IFNA2 CXCL8 CSF3
17 hypersensitivity vasculitis 30.8 TNF MEFV CCR6
18 chronic recurrent multifocal osteomyelitis 30.8 TNF PSTPIP1 NOD2 MEFV
19 skin disease 30.7 TNF NOD2 MMP9 MMP1 MEFV ITGB2
20 erythema elevatum diutinum 30.7 PSTPIP1 CXCL8
21 inflammatory bowel disease 30.7 TNF PSTPIP1 NOD2 MMP9 MMP1 ITGB2
22 spondyloarthropathy 1 30.7 TNF NOD2 IL1R1 CCR6
23 polyarteritis nodosa 30.7 TNF MEFV ITGB2 IFNA2 APOH
24 agammaglobulinemia, x-linked 30.7 PLCG2 CCR6 BTK
25 polycythemia vera 30.7 TNF IFNA2 F3 CSF3
26 osteomyelitis 30.7 TNF NOD2 MMP1 MEFV CXCL8 CSF3
27 ecthyma 30.6 CSF3 BTK
28 fungal infectious disease 30.6 TNF CXCL8 CSF3 CCR6
29 diarrhea 30.6 TNF NOD2 IFNA2 CXCL8 CSF3
30 rosacea 30.6 TNF MMP9 CXCL8
31 panniculitis 30.6 CSF3 CCR6 BTK
32 purpura 30.5 TNF F3 CXCL8 APOH
33 autoimmune disease 30.5 TNF MMP9 F3 CCR6 APOH
34 antiphospholipid syndrome 30.5 TNF F3 APOH
35 diverticulitis 30.5 TNF MMP9 CCR6
36 psoriasis 30.5 TNF NOD2 ITGB2 IL1R1 CXCL8 CCR6
37 pouchitis 30.5 TNF NOD2
38 cholangitis 30.5 TNF NOD2 F3 CXCL8
39 exanthem 30.5 TNF F3 CXCL8 CSF3 CCR6
40 leukemia, acute myeloid 30.5 TNF MMP9 CXCL8 CSF3 CCR6 BTK
41 keratitis, hereditary 30.5 TNF MMP9 CXCL8 CCR6
42 leukocyte adhesion deficiency, type i 30.5 ITGB2 CSF3 CCR6
43 spondylitis 30.5 TNF NOD2 CCR6
44 neutropenia 30.4 TNF IFNA2 CXCL8 CSF3
45 aortitis 30.4 TNF CSF3 CCR6
46 scleritis 30.4 TNF MMP9 ITGB2 CCR6
47 deficiency anemia 30.4 TNF IFNA2 F3 CSF3 CCR6
48 pharyngitis 30.4 TNF MYOM2 MEFV CXCL8 CCR6
49 myeloma, multiple 30.4 MYOM2 ITGB2 IFNA2 CSF3 CCR6
50 brucellosis 30.4 TNF MEFV CXCL8

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma

Symptoms & Phenotypes for Pyoderma

UMLS symptoms related to Pyoderma:


pruritus; exanthema; pustular rash

GenomeRNAi Phenotypes related to Pyoderma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 APOH BTK C7 CCR6 CSF3 CXCL8
2 no effect GR00402-S-2 10.2 APOH BTK C7 CCR6 CSF3 F3

MGI Mouse Phenotypes related to Pyoderma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.03 BTK CCR6 CSF3 F3 IFNA2 IL1R1
2 neoplasm MP:0002006 9.8 BTK F3 IL1R1 MMP1 MMP9 PLCG2
3 hematopoietic system MP:0005397 9.77 BTK CCR6 CSF3 F3 IFNA2 IL1R1
4 integument MP:0010771 9.32 BTK CSF3 F3 IL1R1 ITGB2 MEFV

Drugs & Therapeutics for Pyoderma

Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Inflammatory Agents Phase 4
2 Endothelial Growth Factors Phase 4
3 Mitogens Phase 4
4
Adalimumab Approved, Experimental Phase 3 331731-18-1
5 Antirheumatic Agents Phase 3
6 Pharmaceutical Solutions Phase 3
7
Ixekizumab Approved, Investigational Phase 2 1143503-69-8
8
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
9
Vilobelimab Investigational Phase 2 2250440-41-4
10 Dermatologic Agents Phase 2
11 Complement System Proteins Phase 2
12 Immunosuppressive Agents Phase 2
13
Infliximab Approved 170277-31-3
14
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical 133585-56-5, 60-18-4, 556-02-5 1153 6057
15 Gastrointestinal Agents
16 Vaccines
17 Immunoglobulins, Intravenous Early Phase 1
18 Antineoplastic Agents, Immunological Early Phase 1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 A Novel Therapeutic Treatment of Pyoderma Gangrenosum Recruiting NCT05120726 Phase 4
2 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas Withdrawn NCT00202891 Phase 4 sisomicin
3 A Phase 3 Multicenter, Open-Label, Single Arm Study of the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Subjects in Japan Completed NCT03311464 Phase 3 adalimumab
4 Opened, Multicenter, Randomized, in Parallel Groups Comparative Study to Assess Efficacy and Safety of Dioxidin®, Solution for Topical and External Application 0.025% (Valenta Farm, Russia) and Miramistin®, Solution for Topical Application 0.01% (Infamed K LLC, Russia) in Treatment of Superficial Pyoderma Recruiting NCT05561816 Phase 3 Hydroxymethylquinoxalindioxyde;Benzyl-dimethyl-[3-(tetradecanoylamino)propyl]azanium
5 Hyperbaric Oxygen Therapy for Pyoderma Gangrenosum As a New Treatment Strategy Not yet recruiting NCT05343754 Phase 3 Hyperbaric oxygen
6 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
7 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
8 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Patients With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
9 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Unknown status NCT02733094 Phase 1, Phase 2 Secukinumab
10 An Open-label, Proof of Concept Study of Gevokizumab in the Treatment of the Acute, Inflammatory Phase of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
11 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
12 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Completed NCT03137160 Phase 2
13 Open Label Exploratory Phase 2a Trial to Investigate the Safety and Efficacy of IFX-1 in Treating Subjects With Pyoderma Gangrenosum (Optima) Completed NCT03971643 Phase 2 IFX-1
14 A Phase II Multi Center Open Label Pilot Study To Assess a Potential Effect of an Anti-Il-1-Beta Antagonist in the Treatment of Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
15 Baricitinib in the Treatment of Adults With Pyoderma Gangrenosum (PG) Recruiting NCT04901325 Phase 2 Baricitinib
16 A Phase 2a, Open-label, Proof of Concept Study to Determine the Efficacy and Safety of Etrasimod (APD334) in Patients With Pyoderma Gangrenosum Terminated NCT03072953 Phase 2 APD334
17 The Efficacy and Safety of Secukinumab for the Inflammatory Phase of Pyoderma Gangrenosum Withdrawn NCT04274166 Phase 2 secukinumab 150 mg (2 injections per dose
18 A Multi-Center, Open Label Pilot Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum (HUM 04-37) Withdrawn NCT00690846 Phase 2 adalimumab
19 Multi Center, Open Label Pilot Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira
20 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Unknown status NCT01952275
21 Retrospective Multicenter Observational Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum in Patients Diagnosed With This Pathology Between 2000 and 2015 Unknown status NCT03636737
22 An Open Label Single Center Pilot Study Investigating the Clinical Response and Mechanism of Action of Infliximab in the Treatment of Adults With Inflammatory Bowel Disease Who Have Moderate to Severe Pyoderma Gangrenosum Completed NCT00791557 Infliximab
23 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 4 -The Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
24 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 3: The Incidence of Group A Streptococcal Pharyngitis and the Prevalence of Pyoderma and Scabies in School Children in Fiji, and Establishing Immunologic Correlates of Protection for a J8 Vaccine Completed NCT00284882
25 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji Completed NCT00284843
26 East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities Completed NCT00884728
27 Post-marketing Observational Study for Humira in Participants Diagnosed With Pyoderma Gangrenosum (PG) Recruiting NCT04750213
28 A Real World, Observational Registry of Chronic Wounds and Ulcers to Assess Quality of Care, Evidence Based Practice and Outcomes Using Linked Electronic Health Record Data Recruiting NCT02280733
29 Phase 0/1 Topical Application of the Monoclonal Antibody (Mab) sB24M in Patients With Severe Pyoderma Active, not recruiting NCT04895566 Early Phase 1
30 Expression of the JAK-STAT Signaling Pathway in Pyoderma Gangrenosum Pathological Biopsy Not yet recruiting NCT04792957

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

Organs/tissues related to Pyoderma:

MalaCards : Skin, Neutrophil, Breast, Heart, Endothelial, Myeloid, Spleen

Publications for Pyoderma

Articles related to Pyoderma:

(show top 50) (show all 5198)
# Title Authors PMID Year
1
De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. 53 62
16729790 2006
2
Neutrophilic dermatoses. 62
35870984 2022
3
Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated vasculitis (AAV): a concise review with emphasis on clinical and histopathologic correlation. 62
35599359 2022
4
Blastomycosis-like pyoderma: A pitfall for the misdiagnosis of squamous cell carcinoma. 62
35922899 2022
5
[Clinical analysis of 49 cases of non-inflammasome related conditions]. 62
36444428 2022
6
Rituximab and Pyoderma Gangrenosum: An Investigation of Disproportionality Using a Systems Biology-Informed Approach in the FAERS Database. 62
35933497 2022
7
Pyoderma gangrenosum after mRNA-based SARS-CoV-2 vaccine. 62
35771124 2022
8
Successful treatment of pyoderma gangrenosum using adalimumab in a patient undergoing hemodialysis. 62
35862244 2022
9
Improvement of refractory pyoderma gangrenosum with adjunctive maggot debridement therapy. 62
36468819 2022
10
Treatment of pyoderma gangrenosum with apremilast monotherapy. 62
36345410 2022
11
Disseminated superficial granulomatous pyoderma. 62
35560865 2022
12
A Case of Post-caesarean Pyoderma Gangrenosum. 62
36457428 2022
13
Antibiotic-resistant status and pathogenic clonal complex of canine Streptococcus canis-associated deep pyoderma. 62
36352470 2022
14
Pyoderma Gangrenosum Affecting the Dorsal Hand: A Case Report. 62
36337430 2022
15
A Rare Complication: Postoperative Pyoderma Gangrenosum in Segmental Colitis Associated With Diverticulosis. 62
36001403 2022
16
Characterization of Legal Claims Involving Patients with Pyoderma Gangrenosum. 62
35895601 2022
17
Clinical characteristics and misdiagnosis of pyoderma gangrenosum of the head and neck: A retrospective study. 62
35151756 2022
18
Pyoderma Gangrenosum after COVID-19 Infection and Vaccination. 62
36442730 2022
19
Pyoderma Gangrenosum. 62
36351270 2022
20
Peristomal granulation tissue mimicking peristomal pyoderma gangrenosum in the context of urine-diverting ostomies. 62
36186406 2022
21
[Development of spindle cell squamous cell carcinoma within a longstanding pyoderma gangrenosum]. 62
35471236 2022
22
Clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of pyoderma gangrenosum. 62
36321334 2022
23
Pyoderma caused by Proteus mirabilis in sheep. 62
36049140 2022
24
Novel and Off-Label Biologic Use in the Management of Hidradenitis Suppurativa, Pyoderma Gangrenosum, Lichen Planus, and Seborrheic Dermatitis: A Narrative Review. 62
36434425 2022
25
Skin Infections Due to Panton-Valentine Leukocidin–Producing S. Aureus. 62
36097397 2022
26
Canakinumab treatment in a young girl with refractory chronic recurrent multifocal osteomyelitis associated with pyoderma gangrenosum. 62
36004431 2022
27
Pyoderma Gangrenosum Triggered by COVID-19 Vaccination in a Patient with Ulcerative Colitis: A Case Report. 62
36426538 2022
28
A case with prediagnosis of soft tissue infection who finally diagnosed as pyoderma gangrenosum of ulcerative colitis. 62
36412491 2022
29
Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency. 62
36431272 2022
30
Case Report: Disseminated Vegetating Plaques Occurring over Chronic Recalcitrant Dermatophyosis in an Immunocompromised Patient. 62
36375465 2022
31
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome associated with pyoderma gangrenosum: report of two patients. 62
36345566 2022
32
Clinical characteristics of peristomal pyoderma gangrenosum: A Single Center Retrospective Observational Study. 62
35789032 2022
33
Limb amputation in patients with pyoderma gangrenosum: a multi-institutional case series. 62
36446938 2022
34
In Vitro Antimicrobial Activity of Piper betle Leaf Extract and Some Topical Agents against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus Strains from Canine Pyoderma. 62
36428430 2022
35
Characterizing biofilm formation of Staphylococcus pseudintermedius in different suture materials. 62
36155066 2022
36
Brocq's geometric phagedena over penis with keloidal scars. 62
36220799 2022
37
Prevalence of mecA, mecC and Panton-Valentine-Leukocidin Genes in Clinical Isolates of Coagulase Positive Staphylococci from Dermatological Canine Patients. 62
36422308 2022
38
Juvenile gangrenous vasculitis of the scrotum: systematic review. 62
35323998 2022
39
Multicenter Real-world Experience of Upadacitinib in the Treatment of Crohn's Disease. 62
36272109 2022
40
Postherpetic Trigeminal Trophic Syndrome: A Case Report. 62
36198630 2022
41
A Rare Form of Granulomatosis With Polyangiitis With Pyoderma Gangrenosum. 62
36407211 2022
42
Antibiotic resistance profiles and activity of clove essential oil (Syzygium aromaticum) against Pseudomonas aeruginosa isolated of canine otitis. 62
36425137 2022
43
Abscess-like skin and lung lesions in a patient with acute lymphoblastic leukemia: Pyoderma gangrenosum. 62
35278042 2022
44
Pyoderma gangrenosum-like ulcers over the face in a case of granulomatosis with polyangiitis. 62
36250767 2022
45
Staphylococci isolated from cats in Italy with superficial pyoderma and allergic dermatitis: Characterisation of isolates and their resistance to antimicrobials. 62
36221849 2022
46
Trunk-dominant and classic facial pemphigus foliaceus in dogs - comparison of anti-desmocollin-1 and anti-desmoglein-1 autoantibodies and clinical presentations. 62
35670648 2022
47
Off-label uses of ustekinumab. 62
36208443 2022
48
Aseptic Abscess Syndrome With Ulcerative Colitis and Pyoderma Gangrenosum. 62
35643412 2022
49
An unusual presentation of celiac disease in adult patient. 62
36245465 2022
50
The "Understanding Pyoderma Gangrenosum, Review and Assessment of Disease Effects (UPGRADE)" Project: a protocol for the development of the core outcome domain set for trials in pyoderma gangrenosum. 62
36305958 2022

Variations for Pyoderma

Expression for Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for Pyoderma

Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 BTK CCR6 CSF3 CXCL8 IFNA2 IL1R1
2
Show member pathways
13.34 TNF PLCG2 ITGB2 IL1R1 CXCL8 CSF3
3
Show member pathways
13.31 PLCG2 MMP9 MMP26 MMP10 MMP1 ITGB2
4
Show member pathways
13.23 TNF PLCG2 IL1R1 CXCL8 CSF3 CCR6
5
Show member pathways
13.05 TNF PSTPIP1 PLCG2 NOD2 MMP9 MMP1
6
Show member pathways
13.04 TNF PLCG2 NOD2 MMP9 MMP1 ITGB2
7
Show member pathways
12.76 BTK CXCL8 IFNA2 MMP9 TNF
8
Show member pathways
12.53 TNF PLCG2 IL1R1 F3 CXCL8 BTK
9
Show member pathways
12.43 TNF NOD2 IL1R1 IFNA2 CXCL8
10
Show member pathways
12.21 CSF3 CXCL8 MMP1 MMP9 TNF
11 11.93 TNF MMP9 IL1R1 CXCL8
12 11.83 PLCG2 IL1R1 BTK
13 11.81 ITGB2 CXCL8 CCR6
14
Show member pathways
11.8 PSTPIP1 NOD2 MEFV
15 11.8 TNF MMP9 MMP1 ITGB2 CXCL8
16 11.79 TNF CXCL8 C7
17
Show member pathways
11.72 MMP1 MMP10 MMP26 MMP9 TNF
18 11.71 TNF IL1R1 CCR6
19 11.64 MMP9 MMP1 CXCL8
20 11.58 CSF3 CXCL8 MMP9 TNF
21
Show member pathways
11.56 CXCL8 MMP1 MMP9 TNF
22 11.52 MMP9 MMP10 MMP1 CXCL8
23 11.43 TNF MMP9 MMP1 IFNA2 CXCL8
24 11.38 MMP9 MMP1 CXCL8
25 11.38 TNF IL1R1 CXCL8 CSF3
26 11.3 MMP9 MMP1 CXCL8
27 11.23 TNF MMP1 CXCL8
28 11.2 TNF MMP9 ITGB2
29 11.17 TNF MMP9 CXCL8
30 11.06 TNF PLCG2 NOD2 IFNA2 CXCL8
31 10.94 TNF ITGB2 CXCL8 CSF3 BTK
32
Show member pathways
10.31 TNF CXCL8

GO Terms for Pyoderma

Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.77 TNF NOD2 ITGB2 IL1R1 F3 CCR6
2 extracellular region GO:0005576 9.68 TNF MMP9 MMP26 MMP10 MMP1 IL1R1

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.18 C7 CCR6 CSF3 CXCL8 IL1R1 TNF
2 extracellular matrix organization GO:0030198 10.07 TNF MMP9 MMP26 MMP10 MMP1
3 positive regulation of phagocytosis GO:0050766 10.03 TNF NOD2 BTK
4 positive regulation of interleukin-6 production GO:0032755 10.03 TNF PLCG2 NOD2 BTK
5 extracellular matrix disassembly GO:0022617 10.02 MMP9 MMP10 MMP1
6 inflammatory response GO:0006954 10 CXCL8 IFNA2 IL1R1 ITGB2 MEFV PSTPIP1
7 response to lipopolysaccharide GO:0032496 9.97 TNF PLCG2 NOD2 BTK
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF PLCG2 NOD2 ITGB2 BTK
9 defense response GO:0006952 9.89 TNF NOD2 IFNA2 CXCL8
10 positive regulation of I-kappaB phosphorylation GO:1903721 9.88 TNF PLCG2
11 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.84 TNF NOD2
12 positive regulation of dendritic cell cytokine production GO:0002732 9.81 PLCG2 NOD2
13 positive regulation of synoviocyte proliferation GO:1901647 9.78 TNF BTK
14 positive regulation of prostaglandin-E synthase activity GO:2000363 9.71 ITGB2 NOD2
15 leukocyte migration involved in inflammatory response GO:0002523 9.65 TNF ITGB2 CCR6
16 collagen catabolic process GO:0030574 9.56 MMP9 MMP26 MMP10 MMP1
17 cellular extravasation GO:0045123 9.46 TNF ITGB2
18 calcium-mediated signaling GO:0019722 9.32 TNF PLCG2 CXCL8 CCR6 BTK

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 9.56 MMP9 MMP26 MMP10 MMP1
2 metallopeptidase activity GO:0008237 9.02 MMP9 MMP26 MMP10 MMP1

Sources for Pyoderma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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