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MCID: PYD002
MIFTS: 52

Pyoderma

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pyoderma

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MalaCards integrated aliases for Pyoderma:

Name: Pyoderma 12 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4223
ICD10 33 L08.0
ICD9CM 35 686.0 686.00
MeSH 44 D011711
SNOMED-CT 68 70759006
UMLS 73 C0034212
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Summaries for Pyoderma

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Disease Ontology : 12 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

MalaCards based summary : Pyoderma is related to pyogenic arthritis, pyoderma gangrenosum and acne and pyoderma gangrenosum, and has symptoms including pruritus, exanthema and pustular rash. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial... more...

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Related Diseases for Pyoderma

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Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 pyogenic arthritis, pyoderma gangrenosum and acne 34.2 IL1R1 PSTPIP1
2 pyoderma gangrenosum 33.3 CXCL8 IL1R1 ITGB2 MEFV MMP10 NOD2
3 impetigo 31.9 DSG1 IL36RN
4 ileocolitis 31.8 NOD2 TNF
5 colitis 30.9 CXCL8 NOD2 TNF
6 ulcerative colitis 30.8 CXCL8 NOD2 TNF
7 arthritis 30.4 CXCL8 MMP1 NOD2 PSTPIP1 TNF
8 vasculitis 30.3 IFNA2 MEFV TNF
9 inflammatory bowel disease 30.2 CXCL8 IL1R1 MMP1 NOD2 TNF
10 crohn's colitis 30.1 CXCL8 NOD2 TNF
11 sapho syndrome 30.1 CXCL8 NOD2
12 rheumatoid arthritis 30.0 CXCL8 IL1R1 ITGB2 MMP1 TNF
13 viral infectious disease 29.9 CXCL8 IFNA2 TNF
14 pouchitis 29.9 CXCL8 NOD2
15 cellulitis 29.8 DSG1 IL1R1 TNF
16 erysipelas 29.7 MEFV TNF
17 uveitis 29.6 IFNA2 IL1R1 NOD2 TNF
18 stomatitis 29.6 IFNA2 MEFV TNF
19 spondylarthropathy 29.6 NOD2 TNF
20 leishmaniasis 29.5 CXCL8 ITGB2 TNF
21 periodontal disease 29.5 CXCL8 MMP1 TNF
22 behcet syndrome 29.3 CXCL8 IFNA2 MEFV NOD2 PSTPIP1 TNF
23 psoriatic arthritis 29.2 IL36RN MMP1 NOD2 TNF
24 skin disease 29.2 CXCL8 DSG1 IL36RN TNF
25 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.3
26 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.2
27 crohn's disease 11.4
28 gapo syndrome 11.3
29 cutaneous diphtheria 11.3
30 actinic prurigo 11.2
31 polydactyly, postaxial, type a1 11.1
32 papillon-lefevre syndrome 11.0
33 corticosteroid-sensitive aseptic abscesses 11.0
34 hidradenitis 10.3
35 blastomycosis 10.3
36 myelodysplastic syndrome 10.3
37 systemic onset juvenile idiopathic arthritis 10.2 MEFV TNF
38 exudative glomerulonephritis 10.2 CXCL8 TNF
39 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
40 juvenile ankylosing spondylitis 10.2 MEFV TNF
41 vulvar vestibulitis syndrome 10.2 IL1R1 TNF
42 tungiasis 10.2 CXCL8 TNF
43 streptococcal toxic-shock syndrome 10.2 CXCL8 TNF
44 lymphoma 10.2
45 familial cold autoinflammatory syndrome 1 10.2 IL1R1 MEFV
46 trichuriasis 10.2 CXCL8 TNF
47 cardiac sarcoidosis 10.2 CXCL8 TNF
48 haemophilus influenzae 10.2 CXCL8 TNF
49 relapsing fever 10.2 MEFV TNF
50 opisthorchiasis 10.2 CXCL8 TNF

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma
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Symptoms & Phenotypes for Pyoderma

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UMLS symptoms related to Pyoderma:


pruritus, exanthema, pustular rash

MGI Mouse Phenotypes related to Pyoderma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 BTK IL1R1 IL36RN ITGB2 MEFV NOD2
2 immune system MP:0005387 9.65 BTK IL1R1 IL36RN ITGB2 MEFV MMP1
3 integument MP:0010771 9.17 BTK DSG1 IL1R1 IL36RN ITGB2 MEFV
Sources

Drugs & Therapeutics for Pyoderma

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Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Not Applicable 170277-31-3
2 Anti-Infective Agents Phase 4,Phase 3,Phase 2
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Dermatologic Agents Phase 4,Phase 2,Not Applicable
5 Gastrointestinal Agents Phase 4,Not Applicable
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
7
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
8
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
9
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2 70288-86-7 6474909
10
Azathioprine Approved Phase 3 446-86-6 2265
11
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
12 Mesalamine Phase 3,Phase 2 89-57-6
13 Analgesics, Non-Narcotic Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Anti-Inflammatory Agents Phase 3,Phase 2
16 Analgesics Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antiparasitic Agents Phase 3,Phase 2
19 Aspartic Acid Phase 3
20 alanine Phase 3
21 Immunologic Factors Phase 3,Phase 2,Phase 1
22 Hormone Antagonists Phase 3
23 Liver Extracts Phase 3
24 N-Methylaspartate Phase 3
25 Immunosuppressive Agents Phase 3,Phase 2
26 Antimetabolites Phase 3
27 glucocorticoids Phase 3
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
29 Hormones Phase 3
30 Antimetabolites, Antineoplastic Phase 3
31 Antineoplastic Agents, Hormonal Phase 3
32 Pharmaceutical Solutions Phase 3,Phase 2
33 Ixekizumab Approved, Investigational Phase 2 1143503-69-8
34
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
35 Antibodies, Monoclonal Phase 2,Phase 1
36 Immunoglobulins Phase 2,Phase 1
37 Antibodies Phase 2,Phase 1
38 Calcineurin Inhibitors Phase 2
39
Amoxicillin Approved, Vet_approved 26787-78-0 33613
40 Vedolizumab Approved 943609-66-3
41
Certolizumab pegol Approved 428863-50-7
42
Ustekinumab Approved, Investigational 815610-63-0
43 Vaccines
44 beta-Lactamase Inhibitors
45 Clavulanic Acids
46 Amoxicillin-Potassium Clavulanate Combination

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas (Study P04460) Withdrawn NCT00202891 Phase 4 sisomicin
3 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
4 A Comparison of Once a Day Dose Compared to 2 Doses/Day Completed NCT00505778 Phase 3 Mesalamine Once-Daily;Mesalamine Twice-Daily
5 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
6 A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects Completed NCT01068158 Phase 3 0.5% Ivermectin Cream;Placebo control
7 A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation Completed NCT01066585 Phase 3 Ivermectin Cream;vehicle control
8 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
9 A Study Assessing the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Participants in Japan Recruiting NCT03311464 Phase 3 adalimumab
10 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
11 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
12 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
13 Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
14 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
15 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Completed NCT03137160 Phase 2
16 Canakinumab for Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
17 Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects Completed NCT00994422 Phase 2 Ivermectin cream;vehicle control
18 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
19 Effect of GSK1399686 in Patients With Mild to Moderately Active Ulcerative Colitis Completed NCT01036022 Phase 2 GSK1399686
20 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2 Secukinumab
21 Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum Terminated NCT03072953 Phase 2 APD334
22 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
23 Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira;Humira
24 Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00690846 Phase 2 adalimumab
25 Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease Completed NCT00791557 Not Applicable Infliximab
26 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
27 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
28 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
29 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
30 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
31 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
32 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
33 A Real World, Observational Registry of Chronic Wounds and Ulcers Recruiting NCT02280733
34 Entyvio (Vedolizumab) Long Term Safety Study Recruiting NCT02674308 Vedolizumab
35 Prospective Observational Study on Ustekinumab (Stelara) Assessing Efficacy and Healthcare Resource Utilization in Crohn's Disease Recruiting NCT03495973 Ustekinumab
36 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable
37 Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum Not yet recruiting NCT03636737
38 Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis (RA) and Crohn's Disease (CD) Terminated NCT01577264

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

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Genetic Tests for Pyoderma

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Anatomical Context for Pyoderma

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MalaCards organs/tissues related to Pyoderma:

41
Skin, Neutrophil, T Cells, Lung, Myeloid, Heart, Bone
Sources

Publications for Pyoderma

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Articles related to Pyoderma:

(show top 50) (show all 1371)
# Title Authors Year
1
Pyoderma gangrenosum: a review of pathogenesis and treatment. ( 29406827 )
2018
2
Pyoderma gangrenosum in the genital area: successful treatment using adalimumab. ( 29378677 )
2018
3
A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum. ( 29887980 )
2018
4
Skin Grafting in Pyoderma Gangrenosum. ( 29896322 )
2018
5
The PARACELSUS score: A novel diagnostic tool for pyoderma gangrenosum. ( 29388188 )
2018
6
Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum. ( 29243307 )
2018
7
A Case of Pyoderma Gangrenosum with Myelodysplastic Syndrome. ( 29853768 )
2018
8
Erythema elevatum diutinum associated with severe oropharyngeal ulceration and pyoderma gangrenosum. ( 29750453 )
2018
9
Case of infective endocarditis caused by implanted artificial hair pyoderma. ( 29923626 )
2018
10
Endovenous Treatment of Varicose Veins in Patients With Pyoderma Gangrenosum. ( 29933301 )
2018
11
Epidemiology of pyoderma gangrenosum: Results from an Italian prospective multicentre study. ( 29877043 )
2018
12
Pyoderma Gangrenosum of the Preauricular Area with Ulcerative Colitis: A Case Report and Review. ( 29890815 )
2018
13
Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report. ( 29760625 )
2018
14
A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe. ( 29854503 )
2018
15
A systematic review of pyoderma gangrenosum with pulmonmary involvement: clinical presentation, diagnosis, and management. ( 29377399 )
2018
16
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
17
Blastomycosis-like Pyoderma Arising in Lichen Planus. ( 29462233 )
2018
18
Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report. ( 29425752 )
2018
19
Case of pyoderma gangrenosum-like sporotrichosis caused by Sporothrix globosa in a patient with ulcerative colitis. ( 29488248 )
2018
20
Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. ( 29450466 )
2018
21
Successful treatment with ustekinumab and vacuum-assisted closure therapy in recalcitrant myelodysplastic syndrome-associated pyoderma gangrenosum: case report and literature review. ( 29851121 )
2018
22
A case of neutrophilic dermatoses including pyoderma gangrenosum as a continuous disease spectrum to SAPHO syndrome. ( 29756300 )
2018
23
Pyoderma Gangrenosum of the Breast After Mastopexy. ( 29847306 )
2018
24
Pyoderma Gangranosum-Like Blastomycosis. ( 29486592 )
2018
25
Cutaneous Diphtheria Mimicking Pyoderma Gangrenosum. ( 29282460 )
2018
26
Successful therapy of Pyoderma gangrenosum with a JAK2 inhibitor. ( 29451690 )
2018
27
Pyoderma Gangrenosum Under Dabrafenib and Trametinib for Metastatic Melanoma. ( 29362816 )
2018
28
Erratum: Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 29923506 )
2018
29
A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )
2018
30
Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma. ( 29386837 )
2018
31
The rapidly evolving lesions of ulcerative pyoderma gangrenosum: a timeline. ( 29806128 )
2018
32
Recurrent pyoderma gangrenosum developed after a cesarean section with a 10-year interval. ( 29920658 )
2018
33
<i>LPIN2</i> gene mutation in a patient with overlapping neutrophilic disease (pyoderma gangrenosum and aseptic abscess syndrome). ( 29387759 )
2018
34
The Validity of the Diagnostic Code for Pyoderma Gangrenosum in an Electronic Database. ( 29451671 )
2018
35
Cocaine-induced pyoderma gangrenosum-like lesions. ( 29786948 )
2018
36
Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis. ( 29422812 )
2018
37
Central retinal arterial occlusion in a patient with pyoderma gangrenosum. ( 29941761 )
2018
38
Two cases of bullous pyoderma gangrenosum complicated by Epstein-Barr virus infection. ( 29952293 )
2018
39
Recurrent pyoderma and its underlying primary diseases: a retrospective evaluation of 157 dogs. ( 29419485 )
2018
40
Dental treatment of a rare case of pyoderma gangrenosum with aggressive periodontal disease. ( 29945713 )
2018
41
The impact of underlying disease state on outcomes in patients with pyoderma gangrenosum: A national survey. ( 29438762 )
2018
42
Pyoderma Gangrenosum: A Review for the Gastroenterologist. ( 29788368 )
2018
43
Usefulness of metagenomic analysis in differential diagnosis for pyoderma gangrenosum. ( 29936877 )
2018
44
Pyoderma Gangrenosum Secondary to Severe Congenital Neutropenia. ( 29707446 )
2018
45
Erythema elevatum diutinum verbunden mit schwerer oropharyngealer Ulzeration und Pyoderma gangraenosum. ( 29750450 )
2018
46
Pyoderma gangrenosum-like ulceration of the lower extremity secondary to sunitinib therapy: a case report. ( 29977559 )
2018
47
Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature. ( 30225645 )
2018
48
Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge. ( 30428650 )
2018
49
Superficial granulomatous pyoderma in a patient with ulcerative colitis successfully treated with cyclosporine A. ( 30460989 )
2018
50
Bilateral pyoderma gangrenosum associated with ulcerative colitis and restorative proctocolectomy. ( 30470567 )
2018
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Variations for Pyoderma

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Expression for Pyoderma

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Search GEO for disease gene expression data for Pyoderma.
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Pathways for Pyoderma

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Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.29 BTK CXCL8 DSG1 IFNA2 IL1R1 ITGB2
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.09 CXCL8 IFNA2 IL1R1 ITGB2 MMP1 NOD2
3
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.09 BTK CXCL8 TNF
4
Tuberculosis 37
12.03 IFNA2 ITGB2 NOD2 TNF
5
Bacterial infections in CF airways 22
Show member pathways
 12.02 CXCL8 IL1R1 TNF
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.02 BTK CXCL8 IFNA2 MEFV NOD2 PSTPIP1
7
IL-1 Family Signaling Pathways 65
Show member pathways
 12 CXCL8 IL1R1 IL36RN TNF
8
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.95 BTK CXCL8 IL1R1 ITGB2 MMP1 MMP10
9
Hepatitis C 37
11.9 CXCL8 IFNA2 TNF
10
Osteoclast differentiation 37
11.88 BTK IL1R1 TNF
11
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.87 ITGB2 MMP10 TNF
12
Spinal Cord Injury 1
11.84 CXCL8 IL1R1 TNF
13
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 66
Show member pathways
 11.81 MEFV NOD2 PSTPIP1
14
Interleukin-4 and 13 signaling 66
11.76 CXCL8 ITGB2 MMP1 TNF
15
Matrix Metalloproteinases 1
Show member pathways
 11.74 MMP1 MMP10 TNF
16
Pertussis 37
11.61 CXCL8 ITGB2 TNF
17
Amoebiasis 37
11.6 CXCL8 IL1R1 ITGB2 TNF
18
NF-kappa B signaling pathway 37
11.54 BTK CXCL8 IL1R1 TNF
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.52 CXCL8 MMP1 TNF
20
Cell adhesion_ECM remodeling 22
11.5 CXCL8 MMP1 MMP10
21
Legionellosis 37
11.44 CXCL8 ITGB2 TNF
22
Rheumatoid arthritis 37
11.41 CXCL8 ITGB2 MMP1 TNF
23
Interleukin-10 signaling 66
11.38 CXCL8 IL1R1 TNF
24
Malaria 37
11.36 CXCL8 ITGB2 TNF
25
G-protein signaling_RhoB regulation pathway 22
11.04 BTK CXCL8 TNF
26
EBV LMP1 signaling 1
11 CXCL8 TNF
27
Canonical NF-kappaB pathway 1
10.98 NOD2 TNF
28
Overview of nanoparticle effects 1
10.89 CXCL8 TNF
Sources

GO Terms for Pyoderma

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Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CXCL8 IFNA2 IL1R1 IL36RN MMP1 MMP10

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.89 BTK IL36RN MEFV NOD2 PSTPIP1
2 immune response GO:0006955 9.88 CXCL8 IL1R1 IL36RN TNF
3 regulation of signaling receptor activity GO:0010469 9.86 CXCL8 IFNA2 IL36RN TNF
4 innate immune response GO:0045087 9.85 BTK IL36RN MEFV NOD2 PSTPIP1
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.74 IL36RN NOD2 TNF
6 neutrophil chemotaxis GO:0030593 9.7 CXCL8 IL36RN ITGB2
7 positive regulation of JNK cascade GO:0046330 9.69 IL36RN NOD2 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL8 IL36RN NOD2 TNF
9 regulation of inflammatory response GO:0050727 9.65 IL1R1 NOD2 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.61 IL36RN NOD2 TNF
11 negative regulation of interleukin-6 production GO:0032715 9.59 IL36RN TNF
12 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 BTK ITGB2 NOD2 TNF
14 microglial cell activation GO:0001774 9.55 ITGB2 TNF
15 embryonic digestive tract development GO:0048566 9.54 CXCL8 TNF
16 cytokine-mediated signaling pathway GO:0019221 9.5 CXCL8 IFNA2 IL1R1 IL36RN ITGB2 MMP1
17 defense response GO:0006952 9.46 CXCL8 IFNA2 NOD2 TNF
18 cellular extravasation GO:0045123 9.4 ITGB2 TNF
19 positive regulation of prostaglandin-E synthase activity GO:2000363 9.32 ITGB2 NOD2
20 inflammatory response GO:0006954 9.23 CXCL8 IFNA2 IL1R1 IL36RN ITGB2 MEFV

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IFNA2 IL36RN TNF
Sources

Sources for Pyoderma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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