Aliases & Classifications for Pyoderma

MalaCards integrated aliases for Pyoderma:

Name: Pyoderma 12 54 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:4223
ICD9CM 34 686.0 686.00
MeSH 43 D011711
SNOMED-CT 67 70759006
ICD10 32 L08.0
UMLS 71 C0034212

Summaries for Pyoderma

Disease Ontology : 12 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.

MalaCards based summary : Pyoderma is related to impetigo and crohn's disease, and has symptoms including pruritus, exanthema and pustular rash. An important gene associated with Pyoderma is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are PEDF Induced Signaling and Innate Immune System. The drugs Minocycline and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and t cells, and related phenotypes are hematopoietic system and cellular

Related Diseases for Pyoderma

Diseases related to Pyoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 771)
# Related Disease Score Top Affiliating Genes
1 impetigo 32.5 MYOM2 EDNRB DSG1
2 crohn's disease 32.5 TNF NOD2 NLRP3 CXCL8 CCR6
3 pyoderma gangrenosum 32.0 TNF SIGLEC5 PSTPIP1 NOD2 NLRP3 MMP9
4 vasculitis 31.6 TNF MEFV ITGB2 IFNA2
5 colitis 31.4 TNF NOD2 IL1R1 CXCL8 CCR6
6 hidradenitis 31.3 TNF NOD2 DSG1
7 ulcerative colitis 31.2 TNF NOD2 IL1RN IL1R1 CXCL8 CCR6
8 hidradenitis suppurativa 31.1 TNF NOD2 DSG1
9 crohn's colitis 31.0 TNF NOD2 CXCL8 CCR6
10 myelofibrosis 30.9 TNF IFNA2 CXCL8 CSF3
11 skin disease 30.9 TNF SIGLEC5 ITGB2 DSG1 CXCL8 CCR6
12 fasciitis 30.9 TNF MYOM2 IL1RN CXCL8
13 dermatitis 30.8 TNF NOD2 DSG1 CXCL8 CCR6
14 cellulitis 30.8 TNF IL1R1 DSG1 CCR6
15 purpura 30.8 TNF MEFV F3
16 necrotizing fasciitis 30.8 MYOM2 IL1RN F3 CXCL8
17 keratitis, hereditary 30.6 TNF MMP9 CXCL8 CCR6
18 cyclic neutropenia 30.6 TNF CXCL8 CSF3
19 diverticulitis 30.6 TNF MMP9 CCR6
20 neurofibromatosis, type ii 30.6 TNF SIGLEC5 PSTPIP1 MEFV IL1RN CXCL8
21 rosacea 30.6 TNF MMP9 CXCL8 CCR6
22 leukocyte adhesion deficiency, type i 30.5 ITGB2 CSF3 CCR6
23 aortitis 30.5 TNF NOD2 IL1RN
24 seborrheic dermatitis 30.5 TNF DSG1 CXCL8
25 psoriasis 30.5 TNF NOD2 ITGB2 IL1R1 CXCL8 CCR6
26 sclerosing cholangitis 30.5 TNF NOD2 CXCL8
27 pustulosis of palm and sole 30.5 TNF SIGLEC5 IL1RN CXCL8 CCR6
28 monoclonal gammopathy of uncertain significance 30.5 TNF MYOM2 CCR6
29 ecthyma 30.5 MYOM2 DSG1 CSF3 BTK
30 gingivitis 30.4 TNF MMP9 CXCL8 CSF3
31 sarcoidosis 1 30.4 TNF NOD2 IL1RN CCR6
32 pouchitis 30.4 NOD2 IL1RN CXCL8
33 acute cystitis 30.4 TNF CXCL8 CCR6
34 takayasu arteritis 30.4 TNF MMP9 IL1RN F3
35 hepatitis a 30.3 TNF IFNA2 F3
36 lung disease 30.3 TNF MMP9 F3 CXCL8 CSF3
37 juvenile rheumatoid arthritis 30.3 TNF IL1RN IL1R1 CXCL8
38 psoriatic arthritis 30.3 TNF NOD2 IL1RN CCR6
39 leprosy 3 30.3 TNF NOD2 CXCL8 CCR6
40 dermatitis, atopic 30.3 TNF SIGLEC5 NOD2 CXCL8 CCR6
41 uveitis 30.3 TNF NOD2 IL1R1 IFNA2 CXCL8
42 spondylitis 30.3 TNF NOD2 IL1RN CCR6
43 vascular disease 30.3 TNF MMP9 F3 EDNRB CSF3
44 ileitis 30.3 TNF NOD2 CCR6
45 acute graft versus host disease 30.3 TNF NOD2 CSF3
46 pericarditis 30.3 TNF MEFV IL1RN CXCL8
47 scleritis 30.2 TNF MMP9 ITGB2 IL1RN CCR6
48 osteomyelitis 30.2 TNF NOD2 NLRP3 IL1RN CXCL8 CSF3
49 chronic recurrent multifocal osteomyelitis 30.2 TNF PSTPIP1 NLRP3 MEFV IL1RN
50 peptic ulcer disease 30.2 TNF IL1RN CXCL8

Comorbidity relations with Pyoderma via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Pyoderma:



Diseases related to Pyoderma

Symptoms & Phenotypes for Pyoderma

UMLS symptoms related to Pyoderma:


pruritus, exanthema, pustular rash

MGI Mouse Phenotypes related to Pyoderma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 BTK CCR6 CSF3 EDNRB F3 IL1R1
2 cellular MP:0005384 10.06 BTK EDNRB F3 IL1R1 IL1RN ITGB2
3 immune system MP:0005387 10 BTK CCR6 CSF3 EDNRB F3 IL1R1
4 integument MP:0010771 9.73 BTK CSF3 DSG1 EDNRB F3 IL1R1
5 skeleton MP:0005390 9.32 DSG1 EDNRB IL1R1 IL1RN ITGB2 MEFV

Drugs & Therapeutics for Pyoderma

Drugs for Pyoderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
2
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
3 Anti-Inflammatory Agents Phase 2, Phase 3
4 Antirheumatic Agents Phase 2, Phase 3
5 Pharmaceutical Solutions Phase 3
6 Ixekizumab Approved, Investigational Phase 2 1143503-69-8
7
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
8 Dermatologic Agents Phase 2
9 Immunosuppressive Agents Phase 2
10 Calcineurin Inhibitors Phase 2
11 Antibodies, Monoclonal Phase 1, Phase 2
12 Immunologic Factors Phase 1, Phase 2
13 Immunoglobulins Phase 1, Phase 2
14 Antibodies Phase 1, Phase 2
15
Infliximab Approved 170277-31-3
16
Clavulanate Approved, Vet_approved 58001-44-8 5280980
17
Amoxicillin Approved, Vet_approved 26787-78-0 33613
18 sodium fluoride Approved 7681-49-4
19 Gastrointestinal Agents
20 Vaccines
21 Amoxicillin-Potassium Clavulanate Combination
22 beta-Lactamase Inhibitors
23 Fluorides
24 Listerine

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Sisomicin Cream Vs Nadifloxacin Cream in Primary Pyodermas Withdrawn NCT00202891 Phase 4 sisomicin
2 Minocycline Treatment in Patients With Idiopathic Pulmonary Fibrosis Being Treated With Standard of Care Therapy- a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
3 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
4 A Phase 3 Multicenter, Open-Label, Single Arm Study of the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Subjects in Japan Active, not recruiting NCT03311464 Phase 3 adalimumab
5 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
6 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
7 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Patients With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
8 An Open-label, Proof of Concept Study of Gevokizumab in the Treatment of the Acute, Inflammatory Phase of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
9 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
10 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Completed NCT03137160 Phase 2
11 Topical Tacrolimus 0.1% Ointment for Treatment of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
12 A Phase II Multi Center Open Label Pilot Study To Assess a Potential Effect of an Anti-Il-1-Beta Antagonist in the Treatment of Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
13 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2 Secukinumab
14 Open Label Exploratory Phase 2a Trial to Investigate the Safety and Efficacy of IFX-1 in Treating Subjects With Pyoderma Gangrenosum Recruiting NCT03971643 Phase 2 IFX-1
15 A Phase 2a, Open-label, Proof of Concept Study to Determine the Efficacy and Safety of Etrasimod (APD334) in Patients With Pyoderma Gangrenosum Terminated NCT03072953 Phase 2 APD334
16 A Multi-Center, Open Label Pilot Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum (HUM 04-37) Withdrawn NCT00690846 Phase 2 adalimumab
17 Multi Center, Open Label Pilot Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira;Humira
18 Cutaneous JAK Expression in Vitiligo and Acne Vulgaris. Unknown status NCT03185312
19 An Open Label Single Center Pilot Study Investigating the Clinical Response and Mechanism of Action of Infliximab in the Treatment of Adults With Inflammatory Bowel Disease Who Have Moderate to Severe Pyoderma Gangrenosum Completed NCT00791557 Infliximab
20 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 4 -The Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
21 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji Completed NCT00284843
22 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 3: The Incidence of Group A Streptococcal Pharyngitis and the Prevalence of Pyoderma and Scabies in School Children in Fiji, and Establishing Immunologic Correlates of Protection for a J8 Vaccine Completed NCT00284882
23 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
24 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822
25 East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities Completed NCT00884728
26 Evaluation of Capsule Endoscopy in Patients With Suspected Crohn's Disease Completed NCT00487396
27 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296
28 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Recruiting NCT01952275
29 A Real World, Observational Registry of Chronic Wounds and Ulcers to Assess Quality of Care, Evidence Based Practice and Outcomes Using Linked Electronic Health Record Data Recruiting NCT02280733
30 Genetics and Pathophysiology of Autoinflammatory Disorders. Recruiting NCT00001373
31 Chronic Recurrent Multifocal Osteomyelitis - Search for a Bacterial Cause and Improving Imaging With PET/MRI Recruiting NCT03433287
32 Retrospective Multicenter Observational Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum in Patients Diagnosed With This Pathology Between 2000 and 2015 Not yet recruiting NCT03636737

Search NIH Clinical Center for Pyoderma

Cochrane evidence based reviews: pyoderma

Genetic Tests for Pyoderma

Anatomical Context for Pyoderma

MalaCards organs/tissues related to Pyoderma:

40
Skin, Neutrophil, T Cells, Breast, Myeloid, Lung, Colon

Publications for Pyoderma

Articles related to Pyoderma:

(show top 50) (show all 4457)
# Title Authors PMID Year
1
De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. 54 61
16729790 2006
2
Pyoderma gangrenosum at multiple sites in a post-colostomy ulcerative colitis patient with chronic hepatitis B virus: A case report. 61
31663272 2020
3
Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review. 61
31512760 2020
4
Giant pyoderma gangrenosum in a patient with ulcerative colitis: A case report. 61
32028391 2020
5
Low-dose methotrexate as rescue therapy in patients with hidradenitis suppurativa and pyoderma gangrenosum developing human antichimeric antibodies to infliximab: A retrospective chart review. 61
31541746 2020
6
Peristomal ulcers misdiagnosed as pyoderma gangrenosum: a common error. 61
31667908 2020
7
A rare case of Granulomatous Wegener with multiple Pyoderma gangrenosum-like ulcers. 61
32031728 2020
8
Pyoderma gangrenosum induced by lenalidomide in a case of multiple myeloma. 61
31822948 2020
9
Ibrutinib and Pyoderma Gangrenosum in a Patient With B-Cell Chronic Lymphocytic Leukemia. 61
30839345 2020
10
Ectopic Cushing's syndrome associated with a pheochromocytoma in a dog: a case report. 61
32014021 2020
11
Hemiarthroplasty in a patient with femoral neck fracture and pyoderma gangrenosum: a case report and review of the literature. 61
31931877 2020
12
[Complex treatment of pyoderma gangrenosum after minor trauma and primary surgical intervention with suspected necrotizing fasciitis]. 61
31392345 2020
13
Therapeutic Efficacy of the Combination Therapy of Corticosteroids and 5-Aminosalicylic Acid for Treatment of Pyoderma Gangrenosum with Ulcerative Colitis. 61
32029938 2020
14
Pyoderma gangrenosum arising on vinorelbine infusion site with additional histopathological features of syringosquamous metaplasia. 61
31951074 2020
15
Pyoderma gangrenosum adverse event with Rituximab use: A postmarketing pharmacovigilance analysis. 61
31925868 2020
16
Clinically inactive pyoderma gangrenosum successfully treated with negative pressure therapy and punch grafting. 61
31898868 2020
17
Pyoderma gangrenosum induced by secukinumab-A late paradoxical drug reaction. 61
31705566 2020
18
Pyoderma gangrenosum-like lesions provocated by botulinum injections. 61
31957116 2020
19
Rhupus With Pyoderma Gangrenosum Treated With Immunosuppression and Skin Grafting. 61
32000228 2020
20
Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum. 61
31875484 2020
21
Perioperative Management of Pyoderma Gangrenosum. 61
31927079 2020
22
Pyoderma gangrenosum underrepresentation in non-dermatological literature. 61
31913849 2020
23
Herpes simplex infection mimicking classical pyoderma gangrenosum. 61
31956978 2020
24
Complete genome sequence of a methicillin-resistant Staphylococcus schleiferi strain from canine otitis externa in Korea. 61
31940690 2020
25
Matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for accurate discrimination of Staphylococcus schleiferi subspecies. 61
31902510 2020
26
Association of herpes zoster and chronic inflammatory skin disease in United States inpatients. 61
31958523 2020
27
Current Management of Intestinal Stomas and Their Complications. 61
32002473 2020
28
Pediatric Cullen gangrene: Case report of postoperative pyoderma gangrenosum in a preterm infant with a complex gastrointestinal malformation. 61
31954341 2020
29
[Pyoderma gangrenosum and systemic lupus erythematosus: A rare association]. 61
31495525 2020
30
Common and critical inflammatory dermatoses every pathologist should know. 61
31676787 2020
31
Tumorous formation of the forehead. 61
31993874 2020
32
Drug allergy is associated with the development of extraintestinal manifestations in patients with ulcerative colitis. 61
31594293 2020
33
Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. 61
31925675 2020
34
Paraneoplastic pyoderma gangrenosum associated with adenocarcinoma of the rectosigmoid junction: a case report. 61
31810486 2019
35
Black aortic valve: Minocycline pigmentation complicating treatment of pyoderma gangrenosum. 61
31475398 2019
36
The 5 P's of Pyoderma Gangrenosum 61
31860220 2019
37
Necrotising fasciitis or pyoderma gangrenosum: A fatal dilemma. 61
31418533 2019
38
Treating pyoderma without the use of systemic antibiotics. 61
31814647 2019
39
Psoriasis, arthritis, and pyoderma gangrenosum: an autoinflammatory syndrome or a coincidence? 61
31498876 2019
40
Clinical characteristics and treatment outcomes of 36 pyoderma gangrenosum patients - a retrospective, single institution observation. 61
31310348 2019
41
Characterisation and diagnosis of ulcers in inpatient dermatology consultation services: A multi-centre study. 61
31475449 2019
42
In vitro antibacterial activity of mangosteen (Garcinia mangostana Linn.) crude extract against Staphylococcus pseudintermedius isolates from canine pyoderma. 61
31441182 2019
43
Current clinical issue of skin lesions in patients with inflammatory bowel disease. 61
30838512 2019
44
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease. 61
31254406 2019
45
The Thin bilateral and bipedicled DIEAP flap for axillary reconstruction in hidradenitis suppurativa. 61
31307106 2019
46
Deep cutaneous ulcers and sinus formation in an immunocompetent adult. 61
31789256 2019
47
The prevalence of scabies, pyoderma and other communicable dermatoses in the Bijagos Archipelago, Guinea-Bissau. 61
31738757 2019
48
Pyoderma gangrenosum: a review with special emphasis on Latin America literature. 61
31789268 2019
49
Pyoderma Gangrenosum With Ulcerative Colitis Successfully Treated With Ustekinumab. 61
31151671 2019
50
Pyoderma Gangrenosum in a Patient with Advanced Rectal Cancer Treated with Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. 61
31775997 2019

Variations for Pyoderma

Expression for Pyoderma

Search GEO for disease gene expression data for Pyoderma.

Pathways for Pyoderma

Pathways related to Pyoderma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 TNF IL1RN IL1R1 IFNA2 EDNRB CXCL8
2
Show member pathways
13.45 TNF SIGLEC5 PSTPIP1 NOD2 NLRP3 MMP9
3
Show member pathways
13.13 TNF NOD2 MMP9 ITGB2 IL1RN IL1R1
4
Show member pathways
13.04 TNF NOD2 NLRP3 MMP9 IFNA2 CXCL8
5
Show member pathways
12.74 TNF NLRP3 IFNA2 CXCL8 BTK
6 12.3 TNF NLRP3 IL1R1 CXCL8
7
Show member pathways
12.25 TNF MMP9 CXCL8 CSF3
8 12.21 TNF NLRP3 IL1R1 CXCL8
9 12.14 TNF NOD2 ITGB2 IFNA2
10
Show member pathways
12.05 TNF IL1RN IL1R1 F3 CXCL8
11 11.93 TNF NLRP3 MEFV CXCL8
12 11.92 TNF MMP9 IL1R1 CXCL8
13
Show member pathways
11.89 PSTPIP1 NOD2 NLRP3 MEFV
14 11.87 TNF MMP9 ITGB2 CXCL8
15 11.8 TNF IL1R1 CXCL8 BTK
16 11.79 TNF ITGB2 IL1R1 CXCL8
17 11.71 TNF IL1R1 CCR6
18 11.65 TNF MMP9 IL1RN
19 11.61 TNF NLRP3 ITGB2 CXCL8
20
Show member pathways
11.57 TNF MMP9 CXCL8
21 11.52 TNF ITGB2 CXCL8
22 11.43 TNF MMP9 ITGB2
23 11.42 TNF MMP9 CXCL8 CSF3
24 11.42 TNF PSTPIP1 NOD2 NLRP3 MEFV IFNA2
25 11.36 NOD2 NLRP3 MEFV
26 11.26 TNF ITGB2 CXCL8 CSF3
27 11.24 TNF IL1RN IL1R1 CXCL8 CSF3
28 11.03 NLRP3 MMP9 IL1R1

GO Terms for Pyoderma

Cellular components related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.56 TNF ITGB2 EDNRB BTK
2 cell surface GO:0009986 9.43 TNF NOD2 ITGB2 IL1R1 F3 CCR6
3 ficolin-1-rich granule membrane GO:0101003 9.33 SIGLEC5 ITGB2 DSG1
4 extracellular region GO:0005576 9.32 TNF NLRP3 MMP9 MMP26 IL1RN IL1R1

Biological processes related to Pyoderma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 TNF IL1RN IL1R1 CXCL8 CSF3 CCR6
2 extracellular matrix organization GO:0030198 9.88 TNF MMP9 MMP26 ITGB2
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 TNF NLRP3 F3
4 positive regulation of JNK cascade GO:0046330 9.77 TNF NOD2 IL1RN
5 neutrophil chemotaxis GO:0030593 9.76 ITGB2 IL1RN CXCL8
6 positive regulation of interleukin-6 production GO:0032755 9.73 TNF NOD2 IL1RN
7 humoral immune response GO:0006959 9.72 TNF IFNA2 CCR6
8 defense response GO:0006952 9.72 TNF NOD2 NLRP3 IFNA2 CXCL8
9 calcium-mediated signaling GO:0019722 9.71 EDNRB CXCL8 CCR6 BTK
10 cellular response to lipopolysaccharide GO:0071222 9.7 TNF NOD2 NLRP3 IL1RN EDNRB CXCL8
11 regulation of inflammatory response GO:0050727 9.67 TNF NOD2 NLRP3 IL1R1
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 TNF NOD2 NLRP3 ITGB2 BTK
13 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.61 TNF ITGB2
14 inflammatory response GO:0006954 9.61 TNF PSTPIP1 NLRP3 MEFV ITGB2 IL1RN
15 leukocyte migration involved in inflammatory response GO:0002523 9.57 ITGB2 CCR6
16 cellular response to peptidoglycan GO:0071224 9.54 NOD2 NLRP3
17 positive regulation of type 2 immune response GO:0002830 9.52 NOD2 NLRP3
18 cellular extravasation GO:0045123 9.51 TNF ITGB2
19 cytokine secretion involved in immune response GO:0002374 9.49 NOD2 NLRP3
20 positive regulation of prostaglandin-E synthase activity GO:2000363 9.48 NOD2 ITGB2
21 detection of biotic stimulus GO:0009595 9.46 NOD2 NLRP3
22 cytokine-mediated signaling pathway GO:0019221 9.28 TNF MMP9 ITGB2 IL1RN IL1R1 IFNA2

Molecular functions related to Pyoderma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNF SIGLEC5 PSTPIP1 NOD2 NLRP3 MYOM2
2 cytokine activity GO:0005125 9.02 TNF IL1RN IFNA2 CXCL8 CSF3

Sources for Pyoderma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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