MCID: PYD001
MIFTS: 58

Pyoderma Gangrenosum

Categories: Bone diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pyoderma Gangrenosum

MalaCards integrated aliases for Pyoderma Gangrenosum:

Name: Pyoderma Gangrenosum 12 77 54 60 56 45 15 17 74

Characteristics:

Orphanet epidemiological data:

60
pyoderma gangrenosum
Prevalence: 1-9/100000 (United States),1-9/1000000 (United Kingdom),1-9/1000000 (Spain),1-9/1000000 (Worldwide); Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:8553
ICD9CM 36 686.01
MeSH 45 D017511
SNOMED-CT 69 74578003
ICD10 34 L88
MESH via Orphanet 46 D017511
ICD10 via Orphanet 35 L88
UMLS via Orphanet 75 C0085652
Orphanet 60 ORPHA48104
UMLS 74 C0085652

Summaries for Pyoderma Gangrenosum

NIH Rare Diseases : 54 Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, vasculitis, leukemia, and other conditions. Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100,000 people. Pyoderma gangrenosum belongs to a group of autoinflammatory skin diseases called neutrophilic dermatoses. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections. Ulcerations associated with pyoderma gangrenosum may occur after trauma or injury to the skin, a process called pathergy. Treatment involves wound care and the use of anti-inflammatory agents, including antibiotics, corticosteroids, immunosuppressants, and biologics. 

MalaCards based summary : Pyoderma Gangrenosum is related to pyogenic arthritis, pyoderma gangrenosum and acne and ileocolitis. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and breast, and related phenotypes are fever and arthralgia

Wikipedia : 77 Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that... more...

Related Diseases for Pyoderma Gangrenosum

Diseases related to Pyoderma Gangrenosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 pyogenic arthritis, pyoderma gangrenosum and acne 34.8 IL1R1 PSTPIP1
2 ileocolitis 32.5 NOD2 TNF
3 pyoderma 31.8 CXCL8 IL1R1 ITGB2 MEFV NOD2 PSTPIP1
4 colitis 31.5 CXCL8 NOD2 TNF
5 ulcerative colitis 31.4 CXCL8 NOD2 TNF
6 hidradenitis 31.3 NOD2 TNF
7 hidradenitis suppurativa 31.1 NOD2 TNF
8 inflammatory bowel disease 31.1 CXCL8 NOD2 TNF
9 arthritis 31.0 CXCL8 NOD2 PSTPIP1 TNF
10 fasciitis 31.0 CXCL8 TNF
11 scleritis 30.6 ITGB2 TNF
12 sapho syndrome 30.6 CXCL8 NOD2
13 pouchitis 30.5 CXCL8 NOD2
14 crohn's colitis 30.5 CXCL8 NOD2 TNF
15 rheumatoid arthritis 30.5 CXCL8 IL1R1 ITGB2 TNF
16 erysipelas 30.3 MEFV TNF
17 spondylarthropathy 30.2 NOD2 TNF
18 joint disorders 30.2 IL1R1 TNF
19 ileitis 30.1 NOD2 TNF
20 cellulitis 30.1 IL1R1 TNF
21 uveitis 30.0 IL1R1 NOD2 TNF
22 acute respiratory distress syndrome 29.8 CXCL8 TNF
23 mooren's ulcer 29.8 ITGB2 NLRP3
24 aphthous stomatitis 29.6 MEFV NLRP3 TNF
25 behcet syndrome 29.6 CXCL8 MEFV NOD2 PSTPIP1 TNF
26 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.7
27 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.5
28 crohn's disease 11.8
29 polydactyly, postaxial, type a1 11.4
30 corticosteroid-sensitive aseptic abscesses 11.4
31 leukemia 10.7
32 myelodysplastic syndrome 10.7
33 lymphoma 10.6
34 hepatitis 10.5
35 neurofibromatosis, type ii 10.5
36 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.5
37 vasculitis 10.5
38 breast reconstruction 10.4
39 myelofibrosis 10.4
40 necrotizing fasciitis 10.4
41 systemic lupus erythematosus 10.4
42 osteomyelitis 10.4
43 lupus erythematosus 10.4
44 psoriasis 10.4
45 dermatitis 10.4
46 subcorneal pustular dermatosis 10.4
47 systemic onset juvenile idiopathic arthritis 10.3 MEFV TNF
48 autoinflammation, panniculitis, and dermatosis syndrome 10.3 MEFV TNF
49 juvenile ankylosing spondylitis 10.3 MEFV TNF
50 myeloma, multiple 10.3

Graphical network of the top 20 diseases related to Pyoderma Gangrenosum:



Diseases related to Pyoderma Gangrenosum

Symptoms & Phenotypes for Pyoderma Gangrenosum

Human phenotypes related to Pyoderma Gangrenosum:

60 33 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
3 skin ulcer 60 33 hallmark (90%) Very frequent (99-80%) HP:0200042
4 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
5 papule 60 33 hallmark (90%) Very frequent (99-80%) HP:0200034
6 myositis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100614
7 myelodysplasia 60 33 frequent (33%) Frequent (79-30%) HP:0002863
8 inflammation of the large intestine 60 33 frequent (33%) Frequent (79-30%) HP:0002037
9 increased antibody level in blood 60 33 frequent (33%) Frequent (79-30%) HP:0010702
10 rheumatoid arthritis 60 33 frequent (33%) Frequent (79-30%) HP:0001370
11 pustule 60 33 frequent (33%) Frequent (79-30%) HP:0200039
12 atrophic scars 60 33 frequent (33%) Frequent (79-30%) HP:0001075
13 myeloid leukemia 60 33 frequent (33%) Frequent (79-30%) HP:0012324
14 abnormal blistering of the skin 60 33 occasional (7.5%) Occasional (29-5%) HP:0008066
15 skin vesicle 60 33 occasional (7.5%) Occasional (29-5%) HP:0200037

MGI Mouse Phenotypes related to Pyoderma Gangrenosum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 IL1R1 ITGB2 MEFV NLRP3 NOD2 PSTPIP1
2 immune system MP:0005387 9.56 IL1R1 ITGB2 MEFV MMP10 NLRP3 NOD2
3 skeleton MP:0005390 9.1 IL1R1 ITGB2 MEFV NLRP3 NOD2 TNF

Drugs & Therapeutics for Pyoderma Gangrenosum

Drugs for Pyoderma Gangrenosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Not Applicable 170277-31-3
2 Dermatologic Agents Phase 4,Phase 2,Not Applicable
3 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Gastrointestinal Agents Phase 4,Not Applicable
5
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
6
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
7
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
8
Azathioprine Approved Phase 3 446-86-6 2265
9
carbamide peroxide Approved Phase 3 124-43-6
10 Anti-Bacterial Agents Phase 3
11 Anti-Infective Agents Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13 Anti-Inflammatory Agents Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Mesalamine Phase 3,Phase 2 89-57-6
17 Analgesics Phase 3
18 N-Methylaspartate Phase 3
19 Immunosuppressive Agents Phase 3,Phase 2
20 Antimetabolites Phase 3
21 Hormones Phase 3
22 glucocorticoids Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
24 Liver Extracts Phase 3
25 alanine Phase 3
26 Antimetabolites, Antineoplastic Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Hormone Antagonists Phase 3
29 Immunologic Factors Phase 3,Phase 2,Phase 1
30 Aspartic Acid Phase 3
31 Pharmaceutical Solutions Phase 3,Phase 2
32 Ixekizumab Approved, Investigational Phase 2 1143503-69-8
33
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
34 Antibodies Phase 2,Phase 1
35 Immunoglobulins Phase 2,Phase 1
36 Antibodies, Monoclonal Phase 2,Phase 1
37 Calcineurin Inhibitors Phase 2
38
Certolizumab pegol Approved 428863-50-7
39 Vedolizumab Approved 943609-66-3
40
Ustekinumab Approved, Investigational 815610-63-0

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
3 A Comparison of Once a Day Dose Compared to 2 Doses/Day Completed NCT00505778 Phase 3 Mesalamine Once-Daily;Mesalamine Twice-Daily
4 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
5 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
6 A Study Assessing the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Participants in Japan Active, not recruiting NCT03311464 Phase 3 adalimumab
7 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02326740 Phase 3 gevokizumab;Placebo;gevokizumab open-label
8 An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum Terminated NCT02315417 Phase 3 gevokizumab;Placebo;gevokizumab open-label
9 A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum Terminated NCT02318914 Phase 3 gevokizumab
10 Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum Completed NCT01882504 Phase 2 gevokizumab
11 A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum Completed NCT01965613 Phase 2
12 Canakinumab for Pyoderma Gangrenosum Completed NCT01302795 Phase 2 Canakinumab
13 An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum Completed NCT03137160 Phase 2
14 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
15 Effect of GSK1399686 in Patients With Mild to Moderately Active Ulcerative Colitis Completed NCT01036022 Phase 2 GSK1399686
16 Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum Recruiting NCT02733094 Phase 1, Phase 2 Secukinumab
17 Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum Terminated NCT03072953 Phase 2 APD334
18 Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum Withdrawn NCT00730717 Phase 2 Humira;Humira
19 Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum Withdrawn NCT00690846 Phase 2 adalimumab
20 Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease Completed NCT00791557 Not Applicable Infliximab
21 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
22 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
23 Entyvio (Vedolizumab) Long Term Safety Study Recruiting NCT02674308 Vedolizumab
24 Prospective Observational Study on Ustekinumab (Stelara) Assessing Efficacy and Healthcare Resource Utilization in Crohn's Disease Active, not recruiting NCT03495973 Ustekinumab
25 Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum Not yet recruiting NCT03636737
26 Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis (RA) and Crohn's Disease (CD) Terminated NCT01577264

Search NIH Clinical Center for Pyoderma Gangrenosum

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: pyoderma gangrenosum

Genetic Tests for Pyoderma Gangrenosum

Anatomical Context for Pyoderma Gangrenosum

MalaCards organs/tissues related to Pyoderma Gangrenosum:

42
Skin, Neutrophil, Breast, Myeloid, T Cells, Bone, Monocytes

Publications for Pyoderma Gangrenosum

Articles related to Pyoderma Gangrenosum:

(show top 50) (show all 1875)
# Title Authors Year
1
Colocutaneous fistula through ulcerative colitis and cancer to the pyoderma gangrenosum: a never-ending story for a single patient. Case report. ( 30771797 )
2019
2
Pyoderma gangrenosum and primary cutaneous cryptococcosis in an ulcerative colitis patient. ( 29519678 )
2019
3
Ustekinumab in a patient with pyoderma gangrenosum and refractory Crohn's disease. ( 30795905 )
2019
4
Pyoderma gangrenosum as first manifestation of Crohn's disease. ( 30656577 )
2019
5
Pyoderma gangrenosum misdiagnosed as necrotising fasciitis or a real association between the two? ( 30897232 )
2019
6
Overall and Subgroup Prevalence of Pyoderma Gangrenosum Among Patients with Hidradenitis Suppurativa: a population based analysis in the United States. ( 30738122 )
2019
7
Successful Treatment of Pyoderma Gangrenosum With Skin Grafting in a Patient With Acute Lymphoblastic Leukemia. ( 30882508 )
2019
8
Ibrutinib and Pyoderma Gangrenosum in a Patient With B-Cell Chronic Lymphocytic Leukemia. ( 30839345 )
2019
9
Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia. ( 30710899 )
2019
10
Pyoderma gangrenosum misdiagnosis resulting in amputation: A review. ( 30358767 )
2019
11
Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi-systematic review. ( 30604927 )
2019
12
Managing Ulcers Associated with Pyoderma Gangrenosum with a Urinary Bladder Matrix and Negative-Pressure Wound Therapy. ( 30653185 )
2019
13
Successful Treatment of Pyoderma Gangrenosum with Concomitant Tofacitinib and Infliximab. ( 30753456 )
2019
14
Peristomal pyoderma gangrenosum: an exceedingly rare and overdiagnosed entity? ( 30772334 )
2019
15
Management of a superinfected pyoderma gangrenosum after pacemaker implant. ( 30820397 )
2019
16
Scoring pyoderma gangrenosum. ( 30821389 )
2019
17
Pyoderma gangrenosum in a patient with lipoid proteinosis (Urbach-Wiethe disease). ( 30868669 )
2019
18
Pyoderma gangrenosum: a review of pathogenesis and treatment. ( 29406827 )
2018
19
Pyoderma gangrenosum in the genital area: successful treatment using adalimumab. ( 29378677 )
2018
20
A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum. ( 29887980 )
2018
21
Skin Grafting in Pyoderma Gangrenosum. ( 29896322 )
2018
22
The PARACELSUS score: A novel diagnostic tool for pyoderma gangrenosum. ( 29388188 )
2018
23
Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum. ( 29243307 )
2018
24
A Case of Pyoderma Gangrenosum with Myelodysplastic Syndrome. ( 29853768 )
2018
25
Erythema elevatum diutinum associated with severe oropharyngeal ulceration and pyoderma gangrenosum. ( 29750453 )
2018
26
Endovenous Treatment of Varicose Veins in Patients With Pyoderma Gangrenosum. ( 29933301 )
2018
27
Epidemiology of pyoderma gangrenosum: Results from an Italian prospective multicentre study. ( 29877043 )
2018
28
Pyoderma Gangrenosum of the Preauricular Area with Ulcerative Colitis: A Case Report and Review. ( 29890815 )
2018
29
Pyoderma gangrenosum with its subtype affecting oral mucosa pyostomatitis vegetans following skin melanoma surgical excision in a patient with ulcerative colitis: a case report. ( 29760625 )
2018
30
A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe. ( 29854503 )
2018
31
A systematic review of pyoderma gangrenosum with pulmonmary involvement: clinical presentation, diagnosis, and management. ( 29377399 )
2018
32
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
33
Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report. ( 29425752 )
2018
34
Case of pyoderma gangrenosum-like sporotrichosis caused by Sporothrix globosa in a patient with ulcerative colitis. ( 29488248 )
2018
35
Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. ( 29450466 )
2018
36
Successful treatment with ustekinumab and vacuum-assisted closure therapy in recalcitrant myelodysplastic syndrome-associated pyoderma gangrenosum: case report and literature review. ( 29851121 )
2018
37
A case of neutrophilic dermatoses including pyoderma gangrenosum as a continuous disease spectrum to SAPHO syndrome. ( 29756300 )
2018
38
Pyoderma Gangrenosum of the Breast After Mastopexy. ( 29847306 )
2018
39
Cutaneous Diphtheria Mimicking Pyoderma Gangrenosum. ( 29282460 )
2018
40
Successful therapy of Pyoderma gangrenosum with a JAK2 inhibitor. ( 29451690 )
2018
41
Pyoderma Gangrenosum Under Dabrafenib and Trametinib for Metastatic Melanoma. ( 29362816 )
2018
42
A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )
2018
43
Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma. ( 29386837 )
2018
44
The rapidly evolving lesions of ulcerative pyoderma gangrenosum: a timeline. ( 29806128 )
2018
45
Recurrent pyoderma gangrenosum developed after a cesarean section with a 10-year interval. ( 29920658 )
2018
46
<i>LPIN2</i> gene mutation in a patient with overlapping neutrophilic disease (pyoderma gangrenosum and aseptic abscess syndrome). ( 29387759 )
2018
47
The Validity of the Diagnostic Code for Pyoderma Gangrenosum in an Electronic Database. ( 29451671 )
2018
48
Cocaine-induced pyoderma gangrenosum-like lesions. ( 29786948 )
2018
49
Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis. ( 29422812 )
2018
50
Central retinal arterial occlusion in a patient with pyoderma gangrenosum. ( 29941761 )
2018

Variations for Pyoderma Gangrenosum

Expression for Pyoderma Gangrenosum

Search GEO for disease gene expression data for Pyoderma Gangrenosum.

Pathways for Pyoderma Gangrenosum

Pathways related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CXCL8 IL1R1 ITGB2 MEFV NLRP3 NOD2
2
Show member pathways
13.12 CXCL8 IL1R1 ITGB2 NOD2 TNF
3
Show member pathways
12.76 CXCL8 MEFV NLRP3 NOD2 PSTPIP1 TNF
4 12.14 IL1R1 ITGB2 TNF
5
Show member pathways
12.09 CXCL8 IL1R1 TNF
6
Show member pathways
12.01 CXCL8 IL1R1 ITGB2 MMP10
7 12.01 ITGB2 NOD2 TNF
8
Show member pathways
12 CXCL8 IL1R1 TNF
9
Show member pathways
11.95 CXCL8 IL1R1 TNF
10
Show member pathways
11.81 ITGB2 MMP10 TNF
11 11.78 CXCL8 IL1R1 TNF
12 11.74 CXCL8 ITGB2 TNF
13 11.63 CXCL8 IL1R1 TNF
14 11.59 CXCL8 ITGB2 TNF
15
Show member pathways
11.52 MEFV NLRP3 NOD2 PSTPIP1
16 11.35 CXCL8 ITGB2 TNF
17 11.27 CXCL8 IL1R1 TNF
18
Show member pathways
11.26 IL1R1 TNF
19 11.24 CXCL8 IL1R1 ITGB2 TNF
20 11.23 CXCL8 ITGB2 TNF
21 11.11 MEFV NLRP3 NOD2
22 11 IL1R1 NLRP3
23 10.97 CXCL8 TNF
24 10.93 NOD2 TNF
25 10.83 CXCL8 TNF
26 10.81 CXCL8 ITGB2 NLRP3 TNF

GO Terms for Pyoderma Gangrenosum

Cellular components related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 IL1R1 ITGB2 NOD2 TNF

Biological processes related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.88 MEFV NLRP3 NOD2 PSTPIP1
2 innate immune response GO:0045087 9.86 MEFV NLRP3 NOD2 PSTPIP1
3 cytokine-mediated signaling pathway GO:0019221 9.81 CXCL8 IL1R1 ITGB2 TNF
4 negative regulation of inflammatory response GO:0050728 9.7 MEFV MVK NLRP3
5 cellular response to lipopolysaccharide GO:0071222 9.62 CXCL8 NLRP3 NOD2 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.6 ITGB2 TNF
7 receptor internalization GO:0031623 9.59 CXCL8 ITGB2
8 positive regulation of interleukin-1 beta secretion GO:0050718 9.58 NLRP3 NOD2
9 positive regulation of interleukin-8 production GO:0032757 9.57 NOD2 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 ITGB2 NLRP3 NOD2 TNF
11 microglial cell activation GO:0001774 9.55 ITGB2 TNF
12 embryonic digestive tract development GO:0048566 9.54 CXCL8 TNF
13 cellular response to peptidoglycan GO:0071224 9.49 NLRP3 NOD2
14 positive regulation of type 2 immune response GO:0002830 9.48 NLRP3 NOD2
15 cellular extravasation GO:0045123 9.46 ITGB2 TNF
16 defense response GO:0006952 9.46 CXCL8 NLRP3 NOD2 TNF
17 cytokine secretion involved in immune response GO:0002374 9.43 NLRP3 NOD2
18 detection of biotic stimulus GO:0009595 9.4 NLRP3 NOD2
19 positive regulation of prostaglandin-E synthase activity GO:2000363 9.37 ITGB2 NOD2
20 regulation of inflammatory response GO:0050727 9.26 IL1R1 NLRP3 NOD2 TNF
21 inflammatory response GO:0006954 9.17 CXCL8 IL1R1 ITGB2 MEFV NLRP3 PSTPIP1

Molecular functions related to Pyoderma Gangrenosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 MEFV MVK NLRP3 PSTPIP1 TNF
2 peptidoglycan binding GO:0042834 8.62 NLRP3 NOD2

Sources for Pyoderma Gangrenosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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