FRA
MCID: PYG002
MIFTS: 26

Pyogenic Arthritis, Pyoderma Gangrenosum and Acne (FRA)

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

MalaCards integrated aliases for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:

Name: Pyogenic Arthritis, Pyoderma Gangrenosum and Acne 53 29 6 40 73
Pyogenic Arthritis, Pyoderma Gangrenosum, and Severe Cystic Acne 53
Familial Recurrent Arthritis 53
Papa Syndrome 53
Papas 53
Fra 53

Classifications:



External Ids:

UMLS 73 C1858361

Summaries for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 69126Disease definitionPyogenic arthritis-pyoderma gangrenosum-acne syndrome is a rare pleiotropic autoinflammatory disorder of childhood, primarily affecting the joints and skin.EpidemiologyTo date, only 34 patients with PAPA syndrome have been reported worldwide, from five families (two in the USA, one in Italy, one in the Netherlands, and one in New Zealand).Clinical descriptionThe first affected family contained ten affected members from three generations and manifested variable expression of a pauciarticular, nonaxial, arthritis that began in childhood; pyoderma gangrenosum; and severe cystic acne in adolescence and beyond. PAPA syndrome is a self-limiting disease, but it can lead to severe joint destruction. Synovial fluid is purulent with neutrophil accumulation, but cultures are invariably negative. Recurrent sterile arthritis usually occurs after minor trauma, but can also occur spontaneously. Other less commonly associated features include adult-onset insulin-dependent diabetes mellitus, proteinuria, and abscess formation at the site of parenteral injections (pathergy).EtiologyThe gene responsible for the syndrome, the proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) gene (previously known as the CD2 binding protein 1 (CD2BP1) gene), was cloned in 2002. Only two mutations account for the known cases. Recently, the PSTPIP1 protein has been demonstrated to bind pyrin/marenostrin (P/M), the protein encoded by the MEFV gene, mutations in which cause Familial Mediterranean Fever. PAPA-associated PSTPIP1 mutants exhibit increased binding to P/M.Differential diagnosisDifferential diagnosis for PAPA syndrome should include juvenile idiopathic arthritis and periodic fever.Genetic counselingPAPA syndrome is inherited in an autosomal dominant manner.Management and treatmentArthritis and skin lesions have sometimes been reported to be responsive to glucocorticoids. However, two alternative therapeutics have been suggested so far. In one report, the disease underwent rapid and sustained clinical remission after treatment withthe tumor necrosis factor inhibitor, etanercept. Another recent paper described the effect of recombinant human interleukin (IL)-1 receptor antagonist (anakinra), which appeared to be an effective therapy to treat disease flares in PAPA syndrome.Visit the Orphanet disease page for more resources.

MalaCards based summary : Pyogenic Arthritis, Pyoderma Gangrenosum and Acne, also known as pyogenic arthritis, pyoderma gangrenosum, and severe cystic acne, is related to pyoderma and pyoderma gangrenosum. An important gene associated with Pyogenic Arthritis, Pyoderma Gangrenosum and Acne is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1). Affiliated tissues include skin, neutrophil and lung.

Related Diseases for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Diseases related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 pyoderma 30.8 IL1R1 PSTPIP1
2 pyoderma gangrenosum 30.7 IL1R1 PSTPIP1
3 bartsocas-papas syndrome 12.6
4 fragile site, distamycin a type, rare, fra(16)(q22.1) 12.1
5 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 12.1
6 polydactyly, postaxial, type a1 11.7
7 fragile x syndrome 11.6
8 fraxd 11.1
9 arthritis 10.8
10 neurofibromatosis, type ii 10.4
11 osteonecrosis 10.2
12 erysipelas 10.2
13 septic arthritis 10.2
14 autism 10.2
15 chagas disease 10.1
16 multiple pterygium syndrome, escobar variant 10.1
17 leukemia 10.0
18 sarcoma 10.0
19 plague 10.0
20 osteoporotic fracture 10.0
21 popliteal pterygium syndrome 9.9
22 triiodothyronine receptor auxiliary protein 9.9
23 chand syndrome 9.9
24 familial mediterranean fever 9.9
25 multiple pterygium syndrome, lethal type 9.9
26 synpolydactyly 9.9
27 hidradenitis 9.9
28 arteries, anomalies of 9.9
29 coronary artery anomaly 9.9
30 ischemic heart disease 9.9
31 heart disease 9.9
32 headache 9.9
33 blood group, colton system 9.9
34 sotos syndrome 1 9.9
35 nondisjunction 9.9
36 down syndrome 9.9
37 ablepharon-macrostomia syndrome 9.9
38 lung cancer 9.9
39 endometrial cancer 9.9
40 spondylocostal dysostosis 3, autosomal recessive 9.9
41 ewing sarcoma 9.9
42 membranous nephropathy 9.9
43 neutropenia 9.9
44 brachydactyly 9.9
45 autism spectrum disorder 9.9
46 pollen allergy 9.9
47 rabies 9.9
48 biliary atresia 9.9
49 dysostosis 9.9
50 turner syndrome 9.9

Graphical network of the top 20 diseases related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:



Diseases related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Symptoms & Phenotypes for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Drugs & Therapeutics for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296

Search NIH Clinical Center for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Genetic Tests for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Genetic tests related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:

# Genetic test Affiliating Genes
1 Pyogenic Arthritis, Pyoderma Gangrenosum and Acne 29 PSTPIP1

Anatomical Context for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

MalaCards organs/tissues related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:

41
Skin, Neutrophil, Lung, Heart

Publications for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Articles related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:

(show all 12)
# Title Authors Year
1
Pyogenic arthritis pyoderma gangrenosum and acne syndrome: A rare but important diagnosis for antibiotic-resistant erysipelas-like erythema and osteonecrosis. ( 29943877 )
2018
2
Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature. ( 30225645 )
2018
3
Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome: differential diagnosis of septic arthritis by regular detection of exceedingly high synovial cell counts. ( 28251506 )
2017
4
High level of serum human interleukin-18 in a patient with pyogenic arthritis, pyoderma gangrenosum and acne syndrome. ( 27505688 )
2016
5
Novel PSTPIP1 gene mutation in a patient with pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome. ( 25845478 )
2015
6
A sporadic case of pyogenic arthritis, pyoderma gangrenosum and acne syndrome without an identifiable mutation. ( 23692517 )
2014
7
Fever of undetermined origin in a patient with pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome). ( 24603749 )
2014
8
Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. ( 23293022 )
2013
9
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. ( 22513199 )
2012
10
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. ( 19673875 )
2009
11
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome): report of a sporadic case without an identifiable mutation in the CD2BP1 gene. ( 19700023 )
2009
12
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) associated with hypogammaglobulinemia and elevated serum tumor necrosis factor-alpha levels. ( 17041385 )
2002

Variations for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

ClinVar genetic disease variations for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne:

6 (show top 50) (show all 160)
# Gene Variation Type Significance SNP ID Assembly Location
1 PSTPIP1 NM_003978.4(PSTPIP1): c.748G> C (p.Glu250Gln) single nucleotide variant Pathogenic rs28939089 GRCh37 Chromosome 15, 77324645: 77324645
2 PSTPIP1 NM_003978.4(PSTPIP1): c.748G> C (p.Glu250Gln) single nucleotide variant Pathogenic rs28939089 GRCh38 Chromosome 15, 77032304: 77032304
3 PSTPIP1 NM_003978.4(PSTPIP1): c.688G> A (p.Ala230Thr) single nucleotide variant Pathogenic rs121908130 GRCh37 Chromosome 15, 77323566: 77323566
4 PSTPIP1 NM_003978.4(PSTPIP1): c.688G> A (p.Ala230Thr) single nucleotide variant Pathogenic rs121908130 GRCh38 Chromosome 15, 77031225: 77031225
5 PSTPIP1 NM_003978.4(PSTPIP1): c.741+32_741+33dupGT insertion not provided rs104895417 GRCh37 Chromosome 15, 77323651: 77323652
6 PSTPIP1 NM_003978.4(PSTPIP1): c.741+32_741+33dupGT insertion not provided rs104895417 GRCh38 Chromosome 15, 77031310: 77031311
7 PSTPIP1 NM_003978.4(PSTPIP1): c.748G> A (p.Glu250Lys) single nucleotide variant Pathogenic rs28939089 GRCh37 Chromosome 15, 77324645: 77324645
8 PSTPIP1 NM_003978.4(PSTPIP1): c.748G> A (p.Glu250Lys) single nucleotide variant Pathogenic rs28939089 GRCh38 Chromosome 15, 77032304: 77032304
9 PSTPIP1 NM_003978.4(PSTPIP1): c.796G> A (p.Asp266Asn) single nucleotide variant not provided rs104895418 GRCh37 Chromosome 15, 77324693: 77324693
10 PSTPIP1 NM_003978.4(PSTPIP1): c.796G> A (p.Asp266Asn) single nucleotide variant not provided rs104895418 GRCh38 Chromosome 15, 77032352: 77032352
11 PSTPIP1 NM_003978.4(PSTPIP1): c.204G> A (p.Thr68=) single nucleotide variant Benign rs113386299 GRCh38 Chromosome 15, 77018523: 77018523
12 PSTPIP1 NM_003978.4(PSTPIP1): c.204G> A (p.Thr68=) single nucleotide variant Benign rs113386299 GRCh37 Chromosome 15, 77310864: 77310864
13 PSTPIP1 NM_003978.4(PSTPIP1): c.212+12C> T single nucleotide variant Benign rs3812914 GRCh38 Chromosome 15, 77018543: 77018543
14 PSTPIP1 NM_003978.4(PSTPIP1): c.212+12C> T single nucleotide variant Benign rs3812914 GRCh37 Chromosome 15, 77310884: 77310884
15 PSTPIP1 NM_003978.4(PSTPIP1): c.354+10G> A single nucleotide variant Benign/Likely benign rs370745407 GRCh38 Chromosome 15, 77025614: 77025614
16 PSTPIP1 NM_003978.4(PSTPIP1): c.354+10G> A single nucleotide variant Benign/Likely benign rs370745407 GRCh37 Chromosome 15, 77317955: 77317955
17 PSTPIP1 NM_003978.4(PSTPIP1): c.786C> T (p.Asp262=) single nucleotide variant Benign/Likely benign rs35860563 GRCh38 Chromosome 15, 77032342: 77032342
18 PSTPIP1 NM_003978.4(PSTPIP1): c.786C> T (p.Asp262=) single nucleotide variant Benign/Likely benign rs35860563 GRCh37 Chromosome 15, 77324683: 77324683
19 PSTPIP1 NM_003978.4(PSTPIP1): c.837C> T (p.Pro279=) single nucleotide variant Benign/Likely benign rs149195362 GRCh38 Chromosome 15, 77032393: 77032393
20 PSTPIP1 NM_003978.4(PSTPIP1): c.837C> T (p.Pro279=) single nucleotide variant Benign/Likely benign rs149195362 GRCh37 Chromosome 15, 77324734: 77324734
21 PSTPIP1 NM_003978.4(PSTPIP1): c.908C> T (p.Pro303Leu) single nucleotide variant Benign/Likely benign rs189773500 GRCh38 Chromosome 15, 77032931: 77032931
22 PSTPIP1 NM_003978.4(PSTPIP1): c.908C> T (p.Pro303Leu) single nucleotide variant Benign/Likely benign rs189773500 GRCh37 Chromosome 15, 77325272: 77325272
23 PSTPIP1 NM_003978.4(PSTPIP1): c.1206C> T (p.Asn402=) single nucleotide variant Benign rs146035424 GRCh38 Chromosome 15, 77037131: 77037131
24 PSTPIP1 NM_003978.4(PSTPIP1): c.1206C> T (p.Asn402=) single nucleotide variant Benign rs146035424 GRCh37 Chromosome 15, 77329472: 77329472
25 PSTPIP1 NM_003978.4(PSTPIP1): c.236C> T (p.Ser79Phe) single nucleotide variant Benign/Likely benign rs77026017 GRCh38 Chromosome 15, 77025307: 77025307
26 PSTPIP1 NM_003978.4(PSTPIP1): c.236C> T (p.Ser79Phe) single nucleotide variant Benign/Likely benign rs77026017 GRCh37 Chromosome 15, 77317648: 77317648
27 PSTPIP1 NM_003978.4(PSTPIP1): c.1208G> A (p.Gly403Glu) single nucleotide variant Uncertain significance rs201572812 GRCh38 Chromosome 15, 77037133: 77037133
28 PSTPIP1 NM_003978.4(PSTPIP1): c.1208G> A (p.Gly403Glu) single nucleotide variant Uncertain significance rs201572812 GRCh37 Chromosome 15, 77329474: 77329474
29 PSTPIP1 NM_003978.4(PSTPIP1): c.1213C> T (p.Arg405Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs201253322 GRCh38 Chromosome 15, 77037138: 77037138
30 PSTPIP1 NM_003978.4(PSTPIP1): c.1213C> T (p.Arg405Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs201253322 GRCh37 Chromosome 15, 77329479: 77329479
31 PSTPIP1 NM_003978.4(PSTPIP1): c.1151A> G (p.Asp384Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs200771233 GRCh37 Chromosome 15, 77329417: 77329417
32 PSTPIP1 NM_003978.4(PSTPIP1): c.1151A> G (p.Asp384Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs200771233 GRCh38 Chromosome 15, 77037076: 77037076
33 PSTPIP1 NM_003978.4(PSTPIP1): c.657A> C (p.Gln219His) single nucleotide variant Benign/Likely benign rs139362350 GRCh37 Chromosome 15, 77323535: 77323535
34 PSTPIP1 NM_003978.4(PSTPIP1): c.657A> C (p.Gln219His) single nucleotide variant Benign/Likely benign rs139362350 GRCh38 Chromosome 15, 77031194: 77031194
35 PSTPIP1 NM_003978.4(PSTPIP1): c.882G> A (p.Pro294=) single nucleotide variant Likely benign rs200796501 GRCh38 Chromosome 15, 77032905: 77032905
36 PSTPIP1 NM_003978.4(PSTPIP1): c.882G> A (p.Pro294=) single nucleotide variant Likely benign rs200796501 GRCh37 Chromosome 15, 77325246: 77325246
37 PSTPIP1 NM_003978.4(PSTPIP1): c.1221C> A (p.Phe407Leu) single nucleotide variant Likely benign rs200363654 GRCh37 Chromosome 15, 77329487: 77329487
38 PSTPIP1 NM_003978.4(PSTPIP1): c.1221C> A (p.Phe407Leu) single nucleotide variant Likely benign rs200363654 GRCh38 Chromosome 15, 77037146: 77037146
39 PSTPIP1 NM_003978.4(PSTPIP1): c.147G> A (p.Ala49=) single nucleotide variant Benign/Likely benign rs34618738 GRCh37 Chromosome 15, 77310807: 77310807
40 PSTPIP1 NM_003978.4(PSTPIP1): c.147G> A (p.Ala49=) single nucleotide variant Benign/Likely benign rs34618738 GRCh38 Chromosome 15, 77018466: 77018466
41 PSTPIP1 NM_003978.4(PSTPIP1): c.773G> C (p.Gly258Ala) single nucleotide variant Benign/Likely benign rs34240327 GRCh37 Chromosome 15, 77324670: 77324670
42 PSTPIP1 NM_003978.4(PSTPIP1): c.773G> C (p.Gly258Ala) single nucleotide variant Benign/Likely benign rs34240327 GRCh38 Chromosome 15, 77032329: 77032329
43 PSTPIP1 NM_003978.4(PSTPIP1): c.915C> T (p.Cys305=) single nucleotide variant Benign rs11858480 GRCh38 Chromosome 15, 77032938: 77032938
44 PSTPIP1 NM_003978.4(PSTPIP1): c.915C> T (p.Cys305=) single nucleotide variant Benign rs11858480 GRCh37 Chromosome 15, 77325279: 77325279
45 PSTPIP1 NM_003978.4(PSTPIP1): c.1098G> A (p.Ala366=) single nucleotide variant Benign/Likely benign rs35538044 GRCh38 Chromosome 15, 77035914: 77035914
46 PSTPIP1 NM_003978.4(PSTPIP1): c.1098G> A (p.Ala366=) single nucleotide variant Benign/Likely benign rs35538044 GRCh37 Chromosome 15, 77328255: 77328255
47 PSTPIP1 NM_003978.4(PSTPIP1): c.364G> A (p.Val122Ile) single nucleotide variant Uncertain significance rs886041107 GRCh37 Chromosome 15, 77320202: 77320202
48 PSTPIP1 NM_003978.4(PSTPIP1): c.364G> A (p.Val122Ile) single nucleotide variant Uncertain significance rs886041107 GRCh38 Chromosome 15, 77027861: 77027861
49 PSTPIP1 NM_003978.4(PSTPIP1): c.-405_-402dupCCTG duplication Benign rs55909412 GRCh38 Chromosome 15, 76995169: 76995172
50 PSTPIP1 NM_003978.4(PSTPIP1): c.-405_-402dupCCTG duplication Benign rs55909412 GRCh37 Chromosome 15, 77287510: 77287513

Expression for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Search GEO for disease gene expression data for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne.

Pathways for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

GO Terms for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

Biological processes related to Pyogenic Arthritis, Pyoderma Gangrenosum and Acne according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.62 IL1R1 PSTPIP1

Sources for Pyogenic Arthritis, Pyoderma Gangrenosum and Acne

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