MCID: PYG006
MIFTS: 45

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 53 73
Lobular Capillary Hemangioma 53
Granuloma Pyogenic 55

Classifications:



External Ids:

ICD10 33 L98.0
UMLS 73 C0085653

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 53 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery, freezing, or lasers.

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to capillary hemangioma and angiosarcoma. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Propranolol and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Pyogenic granuloma (also known as a \"eruptive hemangioma\", \"granulation tissue-type hemangioma\",... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 capillary hemangioma 30.7 TEK VEGFA
2 angiosarcoma 29.6 TEK VEGFA
3 intravascular papillary endothelial hyperplasia 29.0 ACTC1 VEGFA
4 mucositis 28.9 MTOR VEGFA
5 hemangioma 28.6 ACTC1 ANGPT2 TEK VEGFA
6 rheumatoid arthritis 28.0 ANGPT1 TEK VEGFA
7 sarcoma 10.3
8 intramuscular hemangioma 10.2 ANGPT1 TEK
9 macrophage activation syndrome 10.2 ANGPT1 ANGPT2
10 adenosquamous pancreas carcinoma 10.2 ANGPT1 TEK
11 twin-to-twin transfusion syndrome 10.2 ANGPT1 ANGPT2
12 burns 10.1
13 melanoma 10.1
14 esophagitis 10.1
15 paronychia 10.1
16 gingivitis 10.1
17 background diabetic retinopathy 10.1 ANGPT2 VEGFA
18 poems syndrome 10.0 ANGPT2 VEGFA
19 ossifying fibroma 10.0
20 diabetic macular edema 10.0 TEK VEGFA
21 macular holes 10.0 ANGPT2 VEGFA
22 endotheliitis 10.0
23 hepatocellular carcinoma 10.0
24 hemangioendothelioma 10.0
25 kaposi sarcoma 9.9
26 sturge-weber syndrome 9.9
27 amelanotic melanoma 9.9
28 weber syndrome 9.9
29 angiomatosis 9.9
30 lymphoma 9.9
31 basal cell carcinoma 1 9.9
32 bacillary angiomatosis 9.9
33 basal cell carcinoma 9.9
34 corneal neovascularization 9.9 TEK VEGFA
35 laryngitis 9.8
36 periodontitis 9.8
37 squamous cell carcinoma 9.8
38 leukemia 9.8
39 angioma, tufted 9.8
40 vaginitis 9.8
41 breast cancer 9.8
42 iron metabolism disease 9.8
43 type i 9.8
44 epulis 9.8
45 gigantism 9.8
46 renal cell carcinoma, nonpapillary 9.8
47 anaplastic large cell lymphoma 9.8
48 conjunctivitis 9.8
49 microvascular complications of diabetes 1 9.8 ANGPT2 VEGFA
50 placenta accreta 9.8 ANGPT1 ANGPT2 TEK

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ANGPT2 MTOR TEK VEGFA ACTC1 ANGPT1
2 homeostasis/metabolism MP:0005376 9.63 ANGPT2 MTOR TEK VEGFA ACTC1 ANGPT1
3 mortality/aging MP:0010768 9.43 ANGPT1 ANGPT2 MTOR TEK VEGFA ACTC1
4 muscle MP:0005369 9.02 MTOR TEK VEGFA ACTC1 ANGPT1

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Adrenergic Agents
3 Adrenergic Antagonists
4 Adrenergic beta-Antagonists
5 Neurotransmitter Agents
6 Anesthetics Not Applicable
7 Fibrin Tissue Adhesive Not Applicable
8 Coagulants Not Applicable
9 Hemostatics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015 Not Applicable
2 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
3 Comparison Between Sutureless and Glue Free Versus Sutured Limbal Conjunctival Autograft in Primary Pterygium Surgery Completed NCT02009072 Not Applicable
4 Maximizing Trichiasis Surgery Success Recruiting NCT03100747 Not Applicable
5 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Not yet recruiting NCT03008629 Not Applicable
6 A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery Not yet recruiting NCT03301974 Not Applicable

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

41
Skin, Tongue, Bone, Colon, Endothelial, Bone Marrow, Testes

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 634)
# Title Authors Year
1
Topical Betaxolol for Treating Relapsing Paronychia with Pyogenic Granuloma-Like Lesions Induced by Epidermal Growth Factor Receptor Inhibitors. ( 29339238 )
2018
2
Coronally advanced flap in conjunction with platelet-rich fibrin-assisted immediate management of residual gingival defect following surgical excision of recurrent pyogenic granuloma in the maxillary esthetic segment. ( 29962710 )
2018
3
Recurrent pyogenic granuloma over nevus flammeus. ( 29547139 )
2018
4
Pyogenic granuloma-like Kaposi's sarcoma on the first toe. ( 29446122 )
2018
5
Pyogenic Granuloma of the Jejunum: an Unusual Cause of Anemia. ( 29374349 )
2018
6
Pyogenic granuloma originating in the pulmonary artery. ( 29721848 )
2018
7
Pyogenic Granuloma in the Tongue in a Five Year Old: A Case Report. ( 29763352 )
2018
8
Nail Pyogenic Granuloma following Treatment with Blinatumomab. ( 29765967 )
2018
9
Peripheral Ameloblastic Fibroma of Anterior Maxillary Gingiva Simulating Pyogenic Granuloma. ( 29950270 )
2018
10
Patient Perspectives: What is a pyogenic granuloma? ( 29575073 )
2018
11
Photodynamic therapy for periungual pyogenic granuloma-like during chemotherapy: our preliminary results. ( 29429004 )
2018
12
Extragingival Pregnancy Pyogenic Granuloma on the Lip. ( 29040143 )
2018
13
Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature. ( 29956465 )
2018
14
Periungual pyogenic granuloma-like lesions following plaster cast immobilization: a case managed with symptomatic therapy. ( 28985457 )
2018
15
No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma. ( 29406329 )
2018
16
Large pregnancy-associated pyogenic granuloma: a case report. ( 29560775 )
2018
17
Topical timolol: An effective treatment option for agminated pyogenic granuloma. ( 29961974 )
2018
18
Simultaneous occurrence of pyogenic granuloma at multiple sites associated with bone loss: Report of a rare case. ( 29769774 )
2018
19
Ureteric pyogenic granuloma: A peculiar case of ureteric obstruction. ( 29511640 )
2018
20
A Case of Bilateral External Auditory Canal Pyogenic Granuloma in a Pregnant Woman. ( 29656634 )
2018
21
Poxvirus-Induced Vascular Angiogenesis Mimicking Pyogenic Granuloma. ( 29697420 )
2018
22
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. ( 29561329 )
2018
23
Combination of ligation and timolol before surgical excision of pyogenic granuloma. ( 29307642 )
2018
24
Esophageal Pyogenic Granuloma: A Case Report and Review of the Literature. ( 29737225 )
2018
25
Pyogenic granuloma: A tumor that mimics infection. ( 29369925 )
2018
26
A challenging diagnosis: Case report of oral metastasis from gastric adenocarcinoma mimicking pyogenic granuloma. ( 29595701 )
2018
27
Malignant melanoma clinically mimicking pyogenic granuloma: comparison of clinical evaluation and histopathology. ( 29750750 )
2018
28
Treatment of paediatric facial pyogenic granuloma with topical ingenol mebutate. ( 28691181 )
2017
29
Malignant fibrous histiocytoma masquerading as pyogenic granuloma. ( 28388346 )
2017
30
Giant pyogenic granuloma of theA finger in an HIV-positive patient. ( 28556978 )
2017
31
Metastatic renal cell carcinoma presenting as multiple pyogenic granuloma-like nodules on the penis. ( 28971132 )
2017
32
An innovative and less invasive management of recurrent pyogenic granuloma in the esthetic zone: A case report with 18-month follow-up. ( 29440794 )
2017
33
Lobular capillary hemangioma (pyogenic granuloma) of the oral cavity. ( 28719705 )
2017
34
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
35
Pyogenic Granuloma of the Penis: An Uncommon Lesion with Unusual Presentation. ( 28413384 )
2017
36
A Research of Pyogenic Granuloma Genesis Factor With Immunohistochemical Analysis. ( 29019819 )
2017
37
Cutaneous epithelioid hemangioendothelioma on the sole mimicking a pyogenic granuloma. ( 28664615 )
2017
38
Pyogenic Granuloma in an Unusual Site. ( 28491928 )
2017
39
Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options. ( 28785323 )
2017
40
Dermoscopy of pyogenic granuloma. ( 28819531 )
2017
41
Pyogenic granuloma of the penis following chancre. ( 28850727 )
2017
42
Combined method to treat periungual pyogenic granuloma: Nail corner plasty, taping and topical bismuth subgallate. ( 28464348 )
2017
43
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis. ( 28658902 )
2017
44
Dermoscopy of Pyogenic Granuloma. ( 29204415 )
2017
45
Pyogenic Granuloma of the Conjunctiva. ( 28445671 )
2017
46
Pyogenic Granuloma: A Retrospective Analysis of Cases Treated Over a 10-Year. ( 28913297 )
2017
47
Pyogenic Granuloma of the Esophagus. ( 28351792 )
2017
48
Pyogenic Granuloma of the Vermilion of the Upper Lip. ( 29034867 )
2017
49
Intravenous lobular capillary haemangioma (pyogenic granuloma): A case report and a review of imaging findings as reported in the literature. ( 28861947 )
2017
50
Optic Disc Pyogenic Granuloma. ( 28868280 )
2017

Variations for Pyogenic Granuloma

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 ANGPT1 ANGPT2 MTOR TEK VEGFA
2
Show member pathways
13.07 ANGPT1 ANGPT2 MTOR TEK VEGFA
3
Show member pathways
13.01 ANGPT1 ANGPT2 MTOR TEK
4
Show member pathways
12.93 ANGPT1 ANGPT2 TEK VEGFA
5
Show member pathways
12.48 ANGPT1 ANGPT2 MTOR TEK VEGFA
6 12.37 ANGPT1 ANGPT2 TEK VEGFA
7
Show member pathways
12.31 ANGPT1 ANGPT2 TEK VEGFA
8
Show member pathways
12.22 ANGPT1 ANGPT2 TEK
9
Show member pathways
12.19 ANGPT2 MTOR VEGFA
10
Show member pathways
11.89 ANGPT1 ANGPT2 TEK
11
Show member pathways
11.76 MTOR TEK
12
Show member pathways
11.73 ANGPT1 ANGPT2 MTOR
13 11.53 ANGPT2 TEK
14 11.45 ANGPT1 TEK VEGFA
15 11.25 MTOR TEK
16 11.05 ANGPT1 TEK
17 11.02 ANGPT1 ANGPT2 MTOR TEK VEGFA
18 10.9 ANGPT1 ANGPT2 VEGFA
19 10.51 ANGPT1 TEK VEGFA

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.96 ACTC1 TEK
2 microvillus GO:0005902 8.62 ANGPT1 TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.94 ANGPT1 ANGPT2 TEK VEGFA
2 cell differentiation GO:0030154 9.9 ANGPT1 ANGPT2 TEK VEGFA
3 positive regulation of gene expression GO:0010628 9.81 ACTC1 MTOR VEGFA
4 negative regulation of apoptotic process GO:0043066 9.71 ACTC1 ANGPT1 TEK VEGFA
5 leukocyte migration GO:0050900 9.7 ANGPT1 ANGPT2 TEK
6 response to hypoxia GO:0001666 9.69 ANGPT2 TEK VEGFA
7 positive regulation of protein phosphorylation GO:0001934 9.67 MTOR TEK VEGFA
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.65 ANGPT1 VEGFA
9 negative regulation of protein phosphorylation GO:0001933 9.65 ANGPT1 MTOR
10 positive regulation of protein kinase B signaling GO:0051897 9.65 ANGPT1 MTOR TEK
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.64 ANGPT1 TEK
12 heart morphogenesis GO:0003007 9.63 MTOR VEGFA
13 positive regulation of angiogenesis GO:0045766 9.63 ANGPT2 TEK VEGFA
14 positive regulation of blood vessel endothelial cell migration GO:0043536 9.62 ANGPT1 VEGFA
15 positive regulation of cell adhesion GO:0045785 9.62 ANGPT1 VEGFA
16 cardiac muscle contraction GO:0060048 9.61 ACTC1 MTOR
17 response to activity GO:0014823 9.61 ANGPT2 MTOR
18 positive chemotaxis GO:0050918 9.59 ANGPT1 VEGFA
19 germ cell development GO:0007281 9.58 ANGPT2 MTOR
20 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ANGPT1 TEK
21 sprouting angiogenesis GO:0002040 9.57 ANGPT1 TEK
22 positive regulation of focal adhesion assembly GO:0051894 9.56 TEK VEGFA
23 maternal process involved in female pregnancy GO:0060135 9.55 ANGPT2 MTOR
24 positive regulation of receptor internalization GO:0002092 9.54 ANGPT1 VEGFA
25 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 ANGPT1 MTOR VEGFA
26 positive regulation of endothelial cell proliferation GO:0001938 9.5 MTOR TEK VEGFA
27 angiogenesis GO:0001525 9.46 ANGPT1 ANGPT2 TEK VEGFA
28 growth GO:0040007 9.43 MTOR VEGFA
29 positive regulation of endothelial cell migration GO:0010595 9.43 ANGPT1 TEK VEGFA
30 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
31 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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