MCID: PYG006
MIFTS: 41

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 52 71 32
Lobular Capillary Hemangioma 52 6
Granuloma Pyogenic 54

Classifications:



External Ids:

ICD10 32 L98.0
UMLS 71 C0085653

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 52 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery , freezing, or lasers.

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to capillary hemangioma and spindle cell sarcoma. An important gene associated with Pyogenic Granuloma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Akt Signaling and Response to elevated platelet cytosolic Ca2+. The drugs Timolol and Maleic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Pyogenic granuloma or pyogenic fibroma is a vascular tumor that occurs on both mucosa and skin, and... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 capillary hemangioma 30.5 TEK CD34 ANGPT2
2 spindle cell sarcoma 30.3 CD34 ACTC1
3 intussusception 30.1 TEK CD34
4 fibroma 29.8 KRAS CD34 ACTC1
5 arteriovenous malformation 29.6 TEK KRAS ANGPT2
6 cutaneous fibrous histiocytoma 29.4 CD34 ACTC1
7 fibrous histiocytoma 29.4 CD34 ACTC1
8 fasciitis 29.3 CD34 ACTC1
9 sarcoma 29.3 NRAS KRAS ANGPT2 ACTC1
10 hemangioma 29.3 TEK KRAS CD34 ANGPT2 ACTC1
11 myeloma, multiple 29.2 NRAS KRAS CD34
12 angiosarcoma 29.1 TEK KRAS CD34 ANGPT2
13 neurofibroma 29.1 CD34 ACTC1
14 renal cell carcinoma, nonpapillary 28.7 TEK NRAS ANGPT2 ACTC1
15 ossifying fibroma 11.8
16 clear cell acanthoma 11.4
17 kaposi sarcoma 10.5
18 paronychia 10.4
19 overgrowth syndrome 10.4
20 neurofibromatosis, type ii 10.3
21 melanoma, cutaneous malignant 10 10.3
22 deficiency anemia 10.3
23 melanoma 10.3
24 bacillary angiomatosis 10.3
25 gingival overgrowth 10.3
26 angiomatosis 10.3
27 amelanotic melanoma 10.3
28 graft-versus-host disease 10.2
29 iron metabolism disease 10.2
30 meibomian cyst 10.2
31 hemangioendothelioma 10.2
32 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.2
33 iron deficiency anemia 10.2
34 keratosis 10.2
35 skin benign neoplasm 10.2
36 acneiform dermatitis 10.2 NRAS KRAS
37 core binding factor acute myeloid leukemia 10.2 NRAS KRAS
38 large intestine adenocarcinoma 10.2 NRAS KRAS
39 oculoectodermal syndrome 10.2 NRAS KRAS
40 ras-associated autoimmune leukoproliferative disorder 10.1 NRAS KRAS
41 human herpesvirus 8 10.1
42 vascular cancer 10.1
43 dermatitis 10.1
44 epulis 10.1
45 dacryoadenitis 10.1
46 dacryocystitis 10.1
47 congenital hemangioma 10.1
48 rasopathy 10.1 NRAS KRAS
49 schimmelpenning-feuerstein-mims syndrome 10.1 NRAS KRAS
50 thyroid tumor 10.1 NRAS KRAS

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ACTC1 ANGPT2 KRAS NRAS TEK
2 homeostasis/metabolism MP:0005376 9.1 ACTC1 ANGPT2 CD34 KRAS NRAS TEK

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 1 26839-75-8 5478 33624
2
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
3 Adrenergic beta-Antagonists Phase 1
4 Antihypertensive Agents Phase 1
5 Adrenergic Agents Phase 1
6 Pharmaceutical Solutions Phase 1
7 Adrenergic Antagonists Phase 1
8 Anti-Arrhythmia Agents Phase 1
9 Lubricant Eye Drops Phase 1
10 Neurotransmitter Agents Phase 1
11 Ophthalmic Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Terminated NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
2 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Unknown status NCT03008629
3 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631
4 In Vivo Confocal Microscopy Study of Pigmented Conjunctival Lesions Terminated NCT01993654

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

40
Skin, Tongue, Endothelial, Colon, Bone, Eye, Lymph Node

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 1614)
# Title Authors PMID Year
1
Congenital disseminated pyogenic granuloma. 54 61
19706097 2009
2
GLUT-1 in oral benign vascular lesions. 54 61
17241430 2007
3
Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. 54 61
16005715 2005
4
The roles of vascular endothelial growth factor and angiopoietin-2 in the regression of pregnancy pyogenic granuloma. 54 61
15089929 2004
5
Benign vascular proliferations--an immunohistochemical and comparative study. 61 54
15469208 2004
6
Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma. 54 61
12147659 2002
7
Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. 61 54
10929871 2000
8
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. 61 54
10697276 2000
9
Intravascular Lobular Capillary Hemangioma (Intravascular Pyogenic Granuloma): A Clinicopathologic Study of 40 Cases. 61
32496432 2020
10
A Huge Oropharyngeal Pyogenic Granuloma in a Patient Presenting with Dysphagia. 61
31489506 2020
11
Use of a water-cooled Nd: YAG pulsed laser in the treatment of giant gingival pyogenic granulomas during pregnancy. 61
31163265 2020
12
Bioengineered Acellular Dermal Matrix Spacer Grafts for Lower Eyelid Retraction Repair: A Report by the American Academy of Ophthalmology. 61
31899031 2020
13
Reactive bite-related tongue lesions in cognitively impaired epilepsy patients: A report of two cases. 61
32441821 2020
14
Histopathological analysis of biopsies of "peri-implant inflammatory lesions." Everything is not what it seems. 61
32378812 2020
15
Treatment of childhood pyogenic granuloma of the nail bed with topical timolol. 61
32472650 2020
16
Lobular Capillary Hemangioma Originating From the Nasopharynx. 61
32352875 2020
17
A capillary hemangioma of lobular subtype (pyogenic granuloma) in the calvarium of a pregnant woman. 61
32240377 2020
18
Duodenal Pyogenic Granuloma. 61
32360803 2020
19
Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis. 61
32329808 2020
20
Identical twins presenting with pyogenic granuloma-like vascular proliferations during isotretinoin therapy. 61
32258328 2020
21
Clinicopathological study of 13 cases of intraoral soft tissue metastatic carcinomas. 61
32257005 2020
22
IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions. 61
32293476 2020
23
Conjunctival Pediatric-Type Follicular Lymphoma. 61
31868792 2020
24
Treatment of epidermal growth factor receptor inhibitor-induced severe paronychia with pyogenic granuloma-like lesions with topical betaxolol: an open-label observation study. 61
31763692 2020
25
[Pyogenic granuloma with satellitosis]. 61
31659388 2020
26
Linear papular pyogenic granuloma: An unusual presentation. 61
31929230 2020
27
Dermoscopic rainbow pattern - now also in pyogenic granuloma. 61
31646626 2020
28
Participation of Intussusceptive Angiogenesis in the Morphogenesis of Lobular Capillary Hemangioma. 61
32193418 2020
29
Benign vascular anomalies: A transition from morphological to etiological classification. 61
32200223 2020
30
Multiple cherry angiomas and pyogenic granuloma in a patient treated with ramucirumab and paclitaxel. 61
32031107 2020
31
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases. 61
32094426 2020
32
Transformation of a naevus into a mixed pyogenic granuloma-naevus mimicking conjunctival melanoma. 61
31889548 2020
33
Central Corneal Pyogenic Granuloma in Aniridia. 61
31973833 2020
34
Clinical and Endoscopic Characteristics of Pyogenic Granuloma in the Small Intestine: A Case Series with Literature Review. 61
31611535 2020
35
Gefitinib-induced pyogenic granuloma in a patient with lung cancer. 61
31898626 2020
36
Dermatopathological characteristics of dermatofibromas from dermatoscopic clues. 61
31264200 2020
37
Usefulness of virtual enteroscopy for the detection of small polypoid lesion in the small bowel, a case report. 61
31991378 2020
38
Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature. 61
31898056 2020
39
Peripheral Ameloblastoma of Upper Gingiva in a Patient with Port-Wine Stain. 61
32454832 2020
40
Relative frequency of oral focal reactive overgrowths: An institutional retrospective study. 61
32508452 2020
41
Peripheral ameloblastoma of the gingiva. 61
32039059 2020
42
Intranasal lobular capillary hemangioma: A series of five cases. 61
32455105 2020
43
Pink bodies with halo. 61
32508464 2020
44
Severe rectal bleeding caused by a small polypoid lobular capillary hemangioma. 61
31863427 2019
45
Human Orf: An Under-recognized Entity. 61
31969245 2019
46
A pinch of salt is all it takes! The novel use of table salt for the effective treatment of pyogenic granuloma. 61
31838042 2019
47
Labial pyogenic granuloma related to trauma: A case report and mini-review. 61
31869498 2019
48
Lobular capillary hemangioma in a patient with ankylosing spondylitis using adalimumab: an exuberant presentation. 61
31789263 2019
49
[Periocular metastasis as differential diagnosis of pyogenic granuloma and therapeutic marker of a systemic disease]. 61
30874885 2019
50
Lobular Capillary Hemangioma of the Ethmoid Sinus: A Report of Two Cases. 61
31763220 2019

Variations for Pyogenic Granuloma

ClinVar genetic disease variations for Pyogenic Granuloma:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 GNA14 NM_004297.4(GNA14):c.614A>T (p.Gln205Leu)SNV Likely pathogenic 548667 rs1554685903 9:80043932-80043932 9:77429016-77429016

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 TEK NRAS KRAS ANGPT2
2
Show member pathways
12.97 TEK NRAS KRAS ANGPT2
3
Show member pathways
12.95 TEK NRAS KRAS ANGPT2
4
Show member pathways
12.5 TEK NRAS KRAS ANGPT2
5 12.22 TEK NRAS KRAS ANGPT2
6
Show member pathways
12.12 TEK NRAS KRAS
7
Show member pathways
12.1 TEK NRAS KRAS ANGPT2
8
Show member pathways
11.92 TEK NRAS KRAS
9
Show member pathways
11.87 NRAS KRAS
10
Show member pathways
11.79 TEK NRAS KRAS ANGPT2
11 11.54 NRAS CD34
12 11.51 NRAS KRAS
13 11.47 NRAS KRAS
14 11.46 NRAS KRAS
15
Show member pathways
11.43 NRAS KRAS
16 11.42 NRAS KRAS
17 11.38 NRAS KRAS
18 11.35 NRAS KRAS
19 11.26 NRAS KRAS
20 11.2 NRAS KRAS
21
Show member pathways
11.17 TEK NRAS KRAS ANGPT2
22 11.13 NRAS KRAS
23 11.05 NRAS KRAS
24 11 NRAS KRAS
25 10.99 NRAS KRAS
26
Show member pathways
10.96 NRAS KRAS
27
Show member pathways
10.89 NRAS KRAS
28 10.82 NRAS KRAS
29 10.78 NRAS KRAS
30 10.71 NRAS KRAS
31 10.44 NRAS KRAS

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.13 TEK KRAS ACTC1
2 basal plasma membrane GO:0009925 8.62 TEK CD34

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.77 TEK NRAS KRAS CD34 ANGPT2
2 positive regulation of gene expression GO:0010628 9.65 KRAS CD34 ACTC1
3 MAPK cascade GO:0000165 9.58 TEK NRAS KRAS
4 leukocyte migration GO:0050900 9.5 TEK CD34 ANGPT2
5 Ras protein signal transduction GO:0007265 9.46 NRAS KRAS
6 positive regulation of endothelial cell proliferation GO:0001938 9.43 TEK NRAS
7 positive regulation of angiogenesis GO:0045766 9.33 TEK CD34 ANGPT2
8 endothelial cell proliferation GO:0001935 9.26 TEK CD34
9 glomerulus vasculature development GO:0072012 8.96 TEK ANGPT2
10 Tie signaling pathway GO:0048014 8.62 TEK ANGPT2

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 NRAS KRAS

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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