MCID: PYG006
MIFTS: 45

Pyogenic Granuloma

Categories: Cancer diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 19 28 71 75 31 33
Lobular Capillary Hemangioma 19 5
Lobular Capillary Haemangioma of Skin 33
Granuloma Telangiectaticum of Skin 33
Pyogenic Granuloma of Skin 33
Granuloma Pyogenicum 33
Granuloma Pyogenic 53

Classifications:



External Ids:

ICD10 31 L98.0
ICD11 33 440675859
UMLS 71 C0085653

Summaries for Pyogenic Granuloma

GARD: 19 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of Pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women.

MalaCards based summary: Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to hemangioendothelioma and leiomyosarcoma. An important gene associated with Pyogenic Granuloma is GNA14 (G Protein Subunit Alpha 14), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and small intestine, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: 75 A pyogenic granuloma or lobular capillary hemangioma is a vascular tumor that occurs on both mucosa and... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 445)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 30.3 FLT4 CD34
2 leiomyosarcoma 30.2 VEGFA PECAM1 ACTC1
3 fibroma 30.2 PECAM1 CD34 ACTC1
4 bacillary angiomatosis 30.1 VEGFA PECAM1 CD34
5 retinal vein occlusion 29.9 VWF VEGFA ANGPT2
6 histiocytoid hemangioma 29.8 PECAM1 CD34
7 microvascular complications of diabetes 1 29.8 VEGFA EPHB4 ANGPT2 ANGPT1
8 impotence 29.8 VWF VEGFA ANGPT1
9 microvascular complications of diabetes 5 29.8 VEGFA TEK SLC2A1 ANGPT2
10 keratitis, hereditary 29.7 VEGFA PECAM1 LYVE1
11 capillary hemangioma 29.7 VEGFA TEK SLC2A1 PECAM1 GNA14 FLT4
12 angiolipoma 29.6 PECAM1 CD34 ACTC1
13 vascular cancer 29.5 VWF VEGFA PECAM1 FLT4 CD34
14 cutaneous fibrous histiocytoma 29.5 CD34 ACTC1
15 intravascular fasciitis 29.4 PECAM1 CD34
16 pseudosarcomatous fibromatosis 29.4 CD34 ACTC1
17 rapidly involuting congenital hemangioma 29.3 SLC2A1 PECAM1 GNA14 FLT4
18 epithelioid hemangioendothelioma 29.3 PECAM1 FLT4 CD34
19 vascular disease 29.2 VWF VEGFA TEK PECAM1 ANGPT1
20 kaposi sarcoma 29.2 VEGFA PECAM1 LYVE1 FLT4 EPHB4 EFNB2
21 intussusception 29.1 VEGFA TEK PECAM1 FLT4 CD34 ANGPT1
22 stroke, ischemic 29.1 VWF VEGFA SLC2A1 PECAM1 ANGPT1
23 cavernous hemangioma 28.4 VWF VEGFA SLC2A1 PECAM1 GNA14 CD34
24 hemangioma 28.3 VWF VEGFA TEK SLC2A1 PECAM1 LYVE1
25 angiosarcoma 28.3 VWF VEGFA TEK PECAM1 FLT4 CD34
26 arteriovenous malformation 28.0 VWF VEGFA TEK SLC2A1 PECAM1 EPHB4
27 clear cell acanthoma 11.2
28 capillary malformations, congenital 10.5
29 sarcoma 10.5
30 paronychia 10.5
31 melanoma 10.4
32 skin benign neoplasm 10.4
33 amelanotic melanoma 10.4
34 overgrowth syndrome 10.4
35 osteofibrous dysplasia 10.4
36 human herpesvirus 8 10.4
37 ossifying fibroma 10.4
38 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.4
39 deficiency anemia 10.4
40 gingival overgrowth 10.4
41 coloboma of optic nerve 10.3
42 basal cell carcinoma 10.3
43 meibomian cyst 10.3
44 graft-versus-host disease 10.3
45 iron metabolism disease 10.3
46 acne 10.3
47 renal cell carcinoma, nonpapillary 10.2
48 basal cell carcinoma 1 10.2
49 iron deficiency anemia 10.2
50 macrophage activation syndrome 10.2 ANGPT2 ANGPT1

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ACTC1 ANGPT1 ANGPT2 CD34 EFNB2 FLT4
2 muscle MP:0005369 9.97 ACTC1 ANGPT1 EFNB2 EPHB4 FLT4 PECAM1
3 cellular MP:0005384 9.81 ACTC1 ANGPT2 CD34 EFNB2 LYVE1 PECAM1
4 embryo MP:0005380 9.8 ANGPT1 EFNB2 EPHB4 FLT4 SLC2A1 TEK
5 cardiovascular system MP:0005385 9.7 ACTC1 ANGPT1 ANGPT2 EFNB2 EPHB4 FLT4
6 immune system MP:0005387 9.32 ANGPT1 ANGPT2 CD34 EFNB2 EPHB4 FLT4

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 3640 5754
2
Hydrocortisone succinate Approved Phase 2, Phase 3 2203-97-6 3643
3
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Hydrocortisone-17-butyrate Phase 2, Phase 3
6 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
7 Anti-Inflammatory Agents Phase 2, Phase 3
8
Ethanolamine oleate Approved 2272-11-9
9 Anesthetics
10 Sclerosing Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone Recruiting NCT05534334 Phase 2, Phase 3 Solu-Cortef
2 Effectiveness of Diode Laser Versus Sclerotherapy in the Treatment of Oral Pyogenic Granuloma: a Randomized-controlled Clinical Trial Completed NCT05099081

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Genetic tests related to Pyogenic Granuloma:

# Genetic test Affiliating Genes
1 Pyogenic Granuloma 28

Anatomical Context for Pyogenic Granuloma

Organs/tissues related to Pyogenic Granuloma:

MalaCards : Skin, Tongue, Small Intestine, Endothelial, Trachea, Colon, Bone Marrow

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 1915)
# Title Authors PMID Year
1
GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. 5
27476652 2016
2
Congenital disseminated pyogenic granuloma. 53 62
19706097 2009
3
GLUT-1 in oral benign vascular lesions. 53 62
17241430 2007
4
Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. 53 62
16005715 2005
5
The roles of vascular endothelial growth factor and angiopoietin-2 in the regression of pregnancy pyogenic granuloma. 53 62
15089929 2004
6
Benign vascular proliferations--an immunohistochemical and comparative study. 53 62
15469208 2004
7
Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma. 53 62
12147659 2002
8
Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. 53 62
10929871 2000
9
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. 53 62
10697276 2000
10
Pyogenic Granuloma of the Auricle. 62
33236929 2022
11
Phialophora infection mimics pyogenic granuloma in a patient with a renal transplant. 62
36117779 2022
12
[Pyogenic granuloma of the finger]. 62
36018338 2022
13
23-Year-old male with multiple giant facial pyogenic granulomas being treated with combined topical timolol and steroid: A case report. 62
36268333 2022
14
Tracheal Lobular Capillary Hemangioma. 62
35776058 2022
15
A Rare Case of Nasal Lobular Capillary Hemangioma Centered at the Pyriform Aperture. 62
36250423 2022
16
Flexor digitorum profundus tendon infiltration by post-traumatic hemangioma. A pediatric case. 62
35569792 2022
17
Recurrence of premalignant oral cavity and oropharynx lesions after pulsed diode laser treatment. 62
35952526 2022
18
Polidocanol: A Review of Off-Label Dermatologic Uses. 62
36054050 2022
19
S2k guideline: Laser therapy of the skin. 62
36098675 2022
20
Routine use of non-absorbable sutures in bi-medial rectus recession as a measure to reduce the incidence of consecutive exotropia. 62
34373609 2022
21
Recurrent Significant Bleeding From Abdominal Wall Giant Pyogenic Granuloma Requiring Multiple Blood Transfusions. 62
36225485 2022
22
Pilot study of a glue-less, suture-less amniotic membrane for pterygium excision. 62
35364745 2022
23
Metastasis of the Mucionous adenocarcinoma of breast to the mandibular gingiva: Rare case report. 62
36197223 2022
24
Treatment of pyogenic granuloma in children with a 595 nm pulsed dye laser: A retrospective study of 212 patients. 62
35395702 2022
25
Intravenous Lobular Capillary Hemangioma: A Case Report and Proposal for New Cutaneous Tender Tumor Differential Diagnosis Acronym. 62
36120217 2022
26
Imiquimod-induced hypertrophic lupus erythematosus-like reaction. 62
36259863 2022
27
Wound Complications with Multiple Wrist Incisions in Distal Radius Reconstruction. 62
35971478 2022
28
An ultrapulsed CO2 laser combined with a long-pulsed Nd:YAG laser for the treatment of oral and maxillofacial pyogenic granuloma. 62
35726842 2022
29
A giant pyogenic granuloma gravidarum in the nasal cavity: A case report. 62
35861196 2022
30
The management of an oral pyogenic granuloma around osseointegrated dental implants. 62
35908249 2022
31
An unusual case of pediatric embryonal rhabdomyosarcoma with subsequent diagnosis of neurofibromatosis type 1. 62
35504621 2022
32
Delayed Eruption of Tooth Due to Peripheral Giant-Cell Granuloma: An Unusual Presentation and Treatment in 15-Year-Old Child Patient. 62
36110691 2022
33
Large Lobular Capillary Hemangioma Associated with Ingrown Toenail: Histopathological Features and Case Report. 62
35892484 2022
34
Pyogenic granuloma of the larynx. 62
35794993 2022
35
Nasal rhinosporidiosis masquerading as pyogenic granuloma in a pediatric patient at a Zonal Referral Hospital in Central Tanzania: Case report. 62
35765285 2022
36
Subungual Exostosis Presenting as a Pyogenic Granuloma-like Lesion with Reactive Myofibroblastic Proliferation in Two Young Women. 62
35735660 2022
37
Intravascular lobular capillary hemangioma of the temporal artery. 62
35493340 2022
38
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis. 62
34401975 2022
39
Dermoscopic Analysis of Vascular Malformations and Tumors Based Upon Dominant Vascular Dermoscopic Features: A Retrospective Analysis From a Tertiary Care Center of East India. 62
35898363 2022
40
A Case of Giant Proliferative Periocular Pyogenic Granuloma. 62
33179542 2022
41
Rapid Involution of Presumed Pyogenic Granuloma with Topical Timolol. 62
35777985 2022
42
Endoscopic resection of a pediatric pyogenic granuloma of the major papilla. 62
33979851 2022
43
Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood. 62
35393626 2022
44
Effectiveness and safety of 0.5% timolol solution in the treatment of pyogenic granuloma: A randomized, double-blind and placebo-controlled study. 62
34672473 2022
45
Dental MRI of Oral Soft-Tissue Tumors-Optimized Use of Black Bone MRI Sequences and a 15-Channel Mandibular Coil. 62
35621910 2022
46
Usefulness of Noninvasive Management With the Gutter Method for Epidermal Growth Factor Receptor Inhibitor-Induced Paronychia, Pyogenic Granuloma-Like Lesion, and Ingrown Nail. 62
35416917 2022
47
Immunohistochemistry for FOSB and FOS is a Useful Ancillary Tool in the Diagnosis of Epithelioid Hemangioma but There are Pitfalls in Interpretation Including Expression in Other Vascular Lesions. 62
35635207 2022
48
Pyogenic granuloma-like Kaposi's sarcoma. 62
26498707 2022
49
Clinicopathological study of 1000 biopsied gingival lesions among dental outpatients: a 22-year retrospective study. 62
35488268 2022
50
Single-stage repair of large full thickness lower eyelid defects using free tarsoconjunctival graft and transposition flap: experience and outcomes. 62
33969795 2022

Variations for Pyogenic Granuloma

ClinVar genetic disease variations for Pyogenic Granuloma:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GNA14 NM_004297.4(GNA14):c.614A>T (p.Gln205Leu) SNV Likely Pathogenic
548667 rs1554685903 GRCh37: 9:80043932-80043932
GRCh38: 9:77429016-77429016

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 VEGFA TEK GNA14 FLT4 EPHB4 ANGPT2
2 13.53 VWF VEGFA TEK GNA14 FLT4 ANGPT1
3
Show member pathways
13.37 VEGFA TEK GNA14 FLT4 EPHB4 ANGPT2
4
Show member pathways
13.29 VEGFA TEK GNA14 FLT4 EPHB4 ANGPT2
5
Show member pathways
13.16 ANGPT1 ANGPT2 EPHB4 FLT4 GNA14 TEK
6
Show member pathways
13.01 VWF VEGFA TEK PECAM1 GNA14 ANGPT2
7
Show member pathways
12.72 TEK GNA14 FLT4 EPHB4
8
Show member pathways
12.67 ANGPT1 ANGPT2 FLT4 SLC2A1 TEK VEGFA
9 12.11 VEGFA TEK SLC2A1 FLT4 ANGPT2 ANGPT1
10
Show member pathways
12 ANGPT1 ANGPT2 PECAM1 TEK
11 11.82 TEK FLT4 EPHB4 EFNB2 ANGPT2
12 11.39 VEGFA TEK ANGPT1
13 11.14 FLT4 EPHB4 ANGPT1
14 11.07 VEGFA SLC2A1
15 11.05 VWF TEK PECAM1 FLT4 EFNB2 ANGPT2
16 11.02 VEGFA SLC2A1 ANGPT2 ANGPT1
17 10.81 EPHB4 EFNB2
18
Show member pathways
10.75 VEGFA FLT4
19 10.75 TEK GNA14 FLT4 EPHB4 ANGPT2 ANGPT1
20 10.4 TEK FLT4

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 TEK SLC2A1 PECAM1 LYVE1 FLT4 EPHB4
2 plasma membrane GO:0005887 9.7 TEK SLC2A1 PECAM1 LYVE1 FLT4 EPHB4
3 membrane raft GO:0045121 9.5 TEK SLC2A1 PECAM1 ANGPT1

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.3 VEGFA TEK FLT4 ANGPT1 ACTC1
2 cell adhesion GO:0007155 10.15 CD34 EFNB2 EPHB4 LYVE1 PECAM1 VWF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.11 ANGPT1 FLT4 TEK VEGFA
4 positive regulation of angiogenesis GO:0045766 10.11 VEGFA TEK CD34 ANGPT2
5 positive regulation of protein phosphorylation GO:0001934 10.1 VEGFA TEK PECAM1 FLT4 ANGPT1
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.09 VEGFA PECAM1 ANGPT1
7 positive regulation of endothelial cell proliferation GO:0001938 10.05 VEGFA TEK FLT4
8 positive regulation of kinase activity GO:0033674 10.03 TEK FLT4 EPHB4
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 10 TEK FLT4 EPHB4 ANGPT1
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.99 VEGFA TEK ANGPT1
11 positive regulation of endothelial cell migration GO:0010595 9.92 ANGPT1 FLT4 TEK VEGFA
12 positive regulation of intracellular signal transduction GO:1902533 9.9 VWF TEK
13 lymph vessel development GO:0001945 9.88 FLT4 EFNB2
14 sprouting angiogenesis GO:0002040 9.86 VEGFA TEK FLT4 ANGPT1
15 positive regulation of protein kinase C signaling GO:0090037 9.85 VEGFA FLT4
16 cell migration involved in sprouting angiogenesis GO:0002042 9.85 VEGFA EPHB4 EFNB2
17 vascular wound healing GO:0061042 9.83 VEGFA CD34
18 blood vessel morphogenesis GO:0048514 9.83 ANGPT2 EFNB2 FLT4
19 glomerular endothelium development GO:0072011 9.78 PECAM1 CD34
20 multicellular organism development GO:0007275 9.71 TEK FLT4 EPHB4
21 glomerulus vasculature development GO:0072012 9.63 TEK ANGPT2 ANGPT1
22 angiogenesis GO:0001525 9.44 VEGFA TEK FLT4 EPHB4 EFNB2 ANGPT2
23 Tie signaling pathway GO:0048014 9.43 TEK ANGPT2 ANGPT1

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.1 TEK FLT4 EPHB4

Sources for Pyogenic Granuloma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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