MCID: PYG006
MIFTS: 46

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 53 73
Lobular Capillary Hemangioma 53 6
Granuloma Pyogenic 55

Classifications:



External Ids:

ICD10 33 L98.0
UMLS 73 C0085653

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 53 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery, freezing, or lasers.

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to capillary hemangioma and hemangioma. An important gene associated with Pyogenic Granuloma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Propranolol and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and colon, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Pyogenic granuloma (also known as a "eruptive hemangioma", "granulation tissue-type hemangioma",... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 capillary hemangioma 30.8 TEK VEGFA
2 hemangioma 29.9 ACTC1 ANGPT1 ANGPT2 TEK VEGFA
3 angiosarcoma 29.8 TEK VEGFA
4 intravascular papillary endothelial hyperplasia 29.5 ACTC1 VEGFA
5 rheumatoid arthritis 29.2 ANGPT1 TEK VEGFA
6 clear cell acanthoma 11.2
7 sarcoma 10.4
8 melanoma 10.3
9 paronychia 10.3
10 kaposi sarcoma 10.2
11 ossifying fibroma 10.2
12 hepatocellular carcinoma 10.1
13 hemangioendothelioma 10.1
14 neurofibromatosis, type i 10.1
15 von hippel-lindau syndrome 10.1
16 asthma 10.1
17 papilloma 10.1
18 pituitary adenoma 10.1
19 headache 10.1
20 intussusception 10.1
21 sturge-weber syndrome 10.1
22 basal cell carcinoma 1 10.1
23 lymphoma 10.1
24 bacillary angiomatosis 10.1
25 basal cell carcinoma 10.1
26 amelanotic melanoma 10.1
27 weber syndrome 10.1
28 intramuscular hemangioma 10.1 ANGPT1 TEK
29 macrophage activation syndrome 10.0 ANGPT1 ANGPT2
30 critical limb ischemia 10.0 TEK VEGFA
31 twin-to-twin transfusion syndrome 10.0 ANGPT1 ANGPT2
32 angiodysplasia 10.0 ANGPT2 VEGFA
33 background diabetic retinopathy 10.0 ANGPT2 VEGFA
34 diabetic macular edema 10.0 TEK VEGFA
35 renal cell carcinoma, nonpapillary 10.0
36 angioma, tufted 10.0
37 human herpesvirus 8 10.0
38 anaplastic large cell lymphoma 10.0
39 leukemia 10.0
40 arteriovenous malformation 10.0
41 squamous cell carcinoma 10.0
42 iron metabolism disease 10.0
43 dermatitis 10.0
44 epulis 10.0
45 macular holes 10.0 ANGPT2 VEGFA
46 glomangioma 9.9 ACTC1 TEK
47 intermittent claudication 9.9 ANGPT2 VEGFA
48 corneal neovascularization 9.9 TEK VEGFA
49 placenta accreta 9.9 ANGPT1 ANGPT2 TEK
50 limb ischemia 9.9 ANGPT2 TEK VEGFA

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ACTC1 ANGPT1 ANGPT2 TEK TP73 VEGFA
2 homeostasis/metabolism MP:0005376 9.73 ACTC1 ANGPT1 ANGPT2 TEK TP73 VEGFA
3 mortality/aging MP:0010768 9.63 ACTC1 ANGPT1 ANGPT2 TEK TP73 VEGFA
4 muscle MP:0005369 9.26 ACTC1 ANGPT1 TEK VEGFA
5 vision/eye MP:0005391 9.02 ANGPT1 ANGPT2 TEK TP73 VEGFA

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Neurotransmitter Agents
3 Adrenergic Antagonists
4 Adrenergic beta-Antagonists
5 Adrenergic Agents
6 Anesthetics Not Applicable
7 Coagulants Not Applicable
8 Hemostatics Not Applicable
9 Fibrin Tissue Adhesive Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Unknown status NCT03008629 Not Applicable
2 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015 Not Applicable
3 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
4 Comparison Between Sutureless and Glue Free Versus Sutured Limbal Conjunctival Autograft in Primary Pterygium Surgery Completed NCT02009072 Not Applicable
5 Maximizing Trichiasis Surgery Success Recruiting NCT03100747 Not Applicable
6 A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery Not yet recruiting NCT03301974 Not Applicable

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

41
Skin, Tongue, Colon, Bone, Trachea, Endothelial, Pituitary

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 796)
# Title Authors Year
1
Topical Betaxolol for Treating Relapsing Paronychia with Pyogenic Granuloma-Like Lesions Induced by Epidermal Growth Factor Receptor Inhibitors. ( 29339238 )
2018
2
Coronally advanced flap in conjunction with platelet-rich fibrin-assisted immediate management of residual gingival defect following surgical excision of recurrent pyogenic granuloma in the maxillary esthetic segment. ( 29962710 )
2018
3
Lobular capillary hemangioma of the mandible: A case report. ( 29704808 )
2018
4
Recurrent pyogenic granuloma over nevus flammeus. ( 29547139 )
2018
5
Pyogenic granuloma-like Kaposi's sarcoma on the first toe. ( 29446122 )
2018
6
Pyogenic Granuloma of the Jejunum: an Unusual Cause of Anemia. ( 29374349 )
2018
7
Pyogenic granuloma originating in the pulmonary artery. ( 29721848 )
2018
8
Pyogenic Granuloma in the Tongue in a Five Year Old: A Case Report. ( 29763352 )
2018
9
Nail Pyogenic Granuloma following Treatment with Blinatumomab. ( 29765967 )
2018
10
Peripheral Ameloblastic Fibroma of Anterior Maxillary Gingiva Simulating Pyogenic Granuloma. ( 29950270 )
2018
11
Patient Perspectives: What is a pyogenic granuloma? ( 29575073 )
2018
12
Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass. ( 29854524 )
2018
13
Photodynamic therapy for periungual pyogenic granuloma-like during chemotherapy: our preliminary results. ( 29429004 )
2018
14
Extragingival Pregnancy Pyogenic Granuloma on the Lip. ( 29040143 )
2018
15
Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature. ( 29956465 )
2018
16
Periungual pyogenic granuloma-like lesions following plaster cast immobilization: a case managed with symptomatic therapy. ( 28985457 )
2018
17
No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma. ( 29406329 )
2018
18
Large pregnancy-associated pyogenic granuloma: a case report. ( 29560775 )
2018
19
Topical timolol: An effective treatment option for agminated pyogenic granuloma. ( 29961974 )
2018
20
Simultaneous occurrence of pyogenic granuloma at multiple sites associated with bone loss: Report of a rare case. ( 29769774 )
2018
21
Ureteric pyogenic granuloma: A peculiar case of ureteric obstruction. ( 29511640 )
2018
22
A Case of Bilateral External Auditory Canal Pyogenic Granuloma in a Pregnant Woman. ( 29656634 )
2018
23
Poxvirus-Induced Vascular Angiogenesis Mimicking Pyogenic Granuloma. ( 29697420 )
2018
24
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. ( 29561329 )
2018
25
Combination of ligation and timolol before surgical excision of pyogenic granuloma. ( 29307642 )
2018
26
Esophageal Pyogenic Granuloma: A Case Report and Review of the Literature. ( 29737225 )
2018
27
A Rare Cause of Resistant Epistaxis: Lobular Capillary Hemangioma Arising from the Inferior Turbinate. ( 29988261 )
2018
28
Intranasal Lobular Capillary Hemangioma with Multiple Sites of Origin during Pregnancy: A Case Report and Literature Review. ( 30319828 )
2018
29
A challenging diagnosis: Case report of oral metastasis from gastric adenocarcinoma mimicking pyogenic granuloma. ( 29595701 )
2018
30
Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma. ( 30258794 )
2018
31
Case series showing the efficacy of 5-aminolaevulinic acid photodynamic therapy for epidermal growth factor receptor inhibitor-induced paronychia and pyogenic granuloma-like lesions. ( 30298920 )
2018
32
Pyogenic granuloma: A tumor that mimics infection. ( 29369925 )
2018
33
Malignant melanoma clinically mimicking pyogenic granuloma: comparison of clinical evaluation and histopathology. ( 29750750 )
2018
34
Efficacy of Nd-YAG laser for treatment of pyogenic granuloma on the fingers and toes. ( 29998355 )
2018
35
Clinical Efficacy and Patient Perceptions of Pyogenic Granuloma Excision Using Diode Laser Versus Conventional Surgical Techniques. ( 30015736 )
2018
36
Non-invasive treatment of pyogenic granuloma by using Nd:YAG laser. ( 30093461 )
2018
37
Pyogenic granuloma of the ampulla of Vater: unexpected cause of gastrointestinal bleeding. ( 30094594 )
2018
38
Management of recurrent pyogenic granuloma with platelet-rich fibrin membrane. ( 30131631 )
2018
39
Possible contribution of autophagy in pyogenic granuloma. ( 30173418 )
2018
40
Purification of Stem Cells from Oral Pyogenic Granuloma Tissue. ( 30197695 )
2018
41
Safety and long-term efficacy of partial matricectomy and phenolization for the treatment of pyogenic granuloma-like lesions induced by epidermal growth factor receptor inhibitors. ( 30249089 )
2018
42
Gastric pyogenic granuloma arising from artificial ulcer scar created by endoscopic submucosal dissection. ( 30314945 )
2018
43
Multifocal congenital pyogenic granuloma successfully treated with oral propranolol. ( 30318648 )
2018
44
Chemotherapy-induced periungual pyogenic granuloma: epidemiology and recurrence rates in our experience. ( 30318883 )
2018
45
Therapeutic approaches to pyogenic granuloma: an updated review. ( 30345507 )
2018
46
Four cases of paradoxical cephalocervical pyogenic granuloma during treatment with paclitaxel and ramucirumab. ( 30379358 )
2018
47
Excisional Biopsy of the Pyogenic Granuloma in Very High-Risk Patient. ( 30405917 )
2018
48
Atypical Presentation of Pyogenic Granuloma of the Right Index Finger: A Rare Case Report. ( 30428790 )
2018
49
Pyogenic granuloma of the larynx: A rare cause of hemoptysis. ( 30514577 )
2018
50
Treatment of paediatric facial pyogenic granuloma with topical ingenol mebutate. ( 28691181 )
2017

Variations for Pyogenic Granuloma

ClinVar genetic disease variations for Pyogenic Granuloma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GNA14 NM_004297.3(GNA14): c.614A> T (p.Gln205Leu) single nucleotide variant Likely pathogenic GRCh37 Chromosome 9, 80043932: 80043932
2 GNA14 NM_004297.3(GNA14): c.614A> T (p.Gln205Leu) single nucleotide variant Likely pathogenic GRCh38 Chromosome 9, 77429016: 77429016

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 ANGPT1 ANGPT2 TEK VEGFA
2
Show member pathways
12.89 ANGPT1 ANGPT2 TEK VEGFA
3
Show member pathways
12.57 ANGPT1 ANGPT2 TEK VEGFA
4 12.34 ANGPT1 ANGPT2 TEK VEGFA
5
Show member pathways
12.26 ANGPT1 ANGPT2 TEK VEGFA
6
Show member pathways
12.2 ANGPT1 ANGPT2 TEK
7
Show member pathways
11.83 ANGPT1 ANGPT2 TEK
8 11.47 ANGPT2 TEK
9 11.39 ANGPT1 TEK VEGFA
10 11.05 ANGPT1 TEK
11 10.92 ANGPT1 ANGPT2 TEK VEGFA
12 10.9 ANGPT1 ANGPT2 VEGFA
13 10.62 ANGPT1 ANGPT2 TEK
14 10.51 ANGPT1 TEK VEGFA
15 9.93 ANGPT1 TEK

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.96 ACTC1 TEK
2 microvillus GO:0005902 8.62 ANGPT1 TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.81 ANGPT1 ANGPT2 TEK VEGFA
2 negative regulation of apoptotic process GO:0043066 9.67 ACTC1 ANGPT1 TEK VEGFA
3 leukocyte migration GO:0050900 9.63 ANGPT1 ANGPT2 TEK
4 kidney development GO:0001822 9.61 TP73 VEGFA
5 response to hypoxia GO:0001666 9.61 ANGPT2 TEK VEGFA
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.6 ANGPT1 TEK
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.59 ANGPT1 VEGFA
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.58 ANGPT1 VEGFA
9 positive regulation of endothelial cell proliferation GO:0001938 9.58 TEK VEGFA
10 positive regulation of angiogenesis GO:0045766 9.58 ANGPT2 TEK VEGFA
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.57 ANGPT1 TEK
12 positive regulation of cell adhesion GO:0045785 9.56 ANGPT1 VEGFA
13 angiogenesis GO:0001525 9.56 ANGPT1 ANGPT2 TEK VEGFA
14 positive regulation of blood vessel endothelial cell migration GO:0043536 9.55 ANGPT1 VEGFA
15 positive chemotaxis GO:0050918 9.54 ANGPT1 VEGFA
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 ANGPT1 TEK
17 positive regulation of endothelial cell migration GO:0010595 9.5 ANGPT1 TEK VEGFA
18 positive regulation of focal adhesion assembly GO:0051894 9.49 TEK VEGFA
19 positive regulation of receptor internalization GO:0002092 9.48 ANGPT1 VEGFA
20 sprouting angiogenesis GO:0002040 9.33 ANGPT1 TEK VEGFA
21 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
22 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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