MCID: PYG006
MIFTS: 46

Pyogenic Granuloma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pyogenic Granuloma

MalaCards integrated aliases for Pyogenic Granuloma:

Name: Pyogenic Granuloma 54 74
Lobular Capillary Hemangioma 54 6
Granuloma Pyogenic 56

Classifications:



External Ids:

ICD10 34 L98.0
UMLS 74 C0085653

Summaries for Pyogenic Granuloma

NIH Rare Diseases : 54 Pyogenic granuloma are small, reddish bumps on the skin that bleed easily due to an abnormally high number of blood vessels. They typically occur on the hands, arms, or face. While the exact cause of pyogenic granulomas is unknown, they often appear following injury. Pyogenic granuloma is often observed in infancy and childhood, but may also be observed in adults, particularly in pregnant women. Small pyogenic granulomas may go away on their own. Larger lesions are treated with surgery, electrocautery, freezing, or lasers.

MalaCards based summary : Pyogenic Granuloma, also known as lobular capillary hemangioma, is related to angiosarcoma and leukemia, chronic lymphocytic 2. An important gene associated with Pyogenic Granuloma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Propranolol and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Pyogenic granuloma is a vascular lesion that occurs on both mucosa and skin, and appears as an... more...

Related Diseases for Pyogenic Granuloma

Diseases related to Pyogenic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.1 KRAS TEK
2 leukemia, chronic lymphocytic 2 29.7 KRAS NRAS
3 hemangioma 29.3 ACTC1 ANGPT1 ANGPT2 KRAS TEK
4 clear cell acanthoma 11.2
5 capillary hemangioma 10.5
6 sarcoma 10.4
7 kaposi sarcoma 10.3
8 melanoma 10.3
9 fibroma 10.3
10 paronychia 10.3
11 ossifying fibroma 10.2
12 schimmelpenning-feuerstein-mims syndrome 10.2 KRAS NRAS
13 hepatocellular carcinoma 10.1
14 burns 10.1
15 hemangioendothelioma 10.1
16 acneiform dermatitis 10.1 KRAS NRAS
17 ras-associated autoimmune leukoproliferative disorder 10.1 KRAS NRAS
18 syringocystadenoma papilliferum 10.1 ACTC1 KRAS
19 core binding factor acute myeloid leukemia 10.1 KRAS NRAS
20 liver angiosarcoma 10.1 KRAS NRAS
21 breast cancer 10.1
22 intussusception 10.1
23 sturge-weber syndrome 10.1
24 basal cell carcinoma 1 10.1
25 deficiency anemia 10.1
26 lymphoma 10.1
27 bacillary angiomatosis 10.1
28 basal cell carcinoma 10.1
29 amelanotic melanoma 10.1
30 weber syndrome 10.1
31 nevus, epidermal 10.1 KRAS NRAS
32 neurofibromatosis, type i 10.1
33 neurofibromatosis, type iv, of riccardi 10.1
34 von hippel-lindau syndrome 10.1
35 asthma 10.1
36 squamous cell papilloma 10.1
37 papilloma 10.1
38 pituitary adenoma 10.1
39 central nervous system hemangioma 10.1
40 headache 10.1
41 glomangioma 10.1 ACTC1 TEK
42 neurofibromatosis, type ii 10.0
43 renal cell carcinoma, nonpapillary 10.0
44 strabismus 10.0
45 angioma, tufted 10.0
46 human herpesvirus 8 10.0
47 anaplastic large cell lymphoma 10.0
48 leukemia 10.0
49 arteriovenous malformation 10.0
50 squamous cell carcinoma 10.0

Graphical network of the top 20 diseases related to Pyogenic Granuloma:



Diseases related to Pyogenic Granuloma

Symptoms & Phenotypes for Pyogenic Granuloma

MGI Mouse Phenotypes related to Pyogenic Granuloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ACTC1 ANGPT1 ANGPT2 KRAS NRAS TEK
2 homeostasis/metabolism MP:0005376 9.73 ACTC1 ANGPT1 ANGPT2 KRAS NRAS TEK
3 mortality/aging MP:0010768 9.63 ACTC1 ANGPT1 ANGPT2 KRAS NRAS TEK
4 muscle MP:0005369 9.26 ACTC1 ANGPT1 KRAS TEK
5 vision/eye MP:0005391 9.02 ANGPT1 ANGPT2 KRAS NRAS TEK

Drugs & Therapeutics for Pyogenic Granuloma

Drugs for Pyogenic Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2 Neurotransmitter Agents
3 Adrenergic Antagonists
4 Adrenergic Agents
5 Adrenergic beta-Antagonists
6 Anesthetics Not Applicable
7 Fibrin Tissue Adhesive Not Applicable
8 Hemostatics Not Applicable
9 Coagulants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Nail Brace for Treatment of Ingrown Toenails Unknown status NCT03008629 Not Applicable
2 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015 Not Applicable
3 Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors Completed NCT02334930
4 Comparison Between Sutureless and Glue Free Versus Sutured Limbal Conjunctival Autograft in Primary Pterygium Surgery Completed NCT02009072 Not Applicable
5 Repeat Surgery for Patients With Post-operative Trachomatous Trichiasis Trial Recruiting NCT03886519 Not Applicable
6 Maximizing Trichiasis Surgery Success Active, not recruiting NCT03100747 Not Applicable
7 A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery Not yet recruiting NCT03301974 Not Applicable

Search NIH Clinical Center for Pyogenic Granuloma

Genetic Tests for Pyogenic Granuloma

Anatomical Context for Pyogenic Granuloma

MalaCards organs/tissues related to Pyogenic Granuloma:

42
Skin, Tongue, Bone, Colon, Endothelial, Trachea, Myeloid

Publications for Pyogenic Granuloma

Articles related to Pyogenic Granuloma:

(show top 50) (show all 817)
# Title Authors Year
1
Treatment for Pyogenic Granuloma after Burns: A Retrospective, Single-Center Study Involving 15 Cases. ( 31043222 )
2019
2
Treatment for Pyogenic Granuloma after Burns: A Retrospective, Single-Center Study Involving 15 Cases. ( 31053199 )
2019
3
Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills. ( 30628110 )
2019
4
Lobular Capillary Hemangioma in Post-Pneumonectomy Bronchial Stump. ( 30850193 )
2019
5
Bleeding to the Point of Anemia in Lobular Capillary Hemangioma of the Upper Lip. ( 30940344 )
2019
6
Small Bowel Pyogenic Granuloma With Cytomegalovirus Infection in a Patient With Crohn's Disease (Report of a Case and Review of the Literature). ( 30587632 )
2019
7
Case series showing the efficacy of 5-aminolaevulinic acid photodynamic therapy for epidermal growth factor receptor inhibitor-induced paronychia and pyogenic granuloma-like lesions. ( 30298920 )
2019
8
Recurrent pyogenic granuloma over nevus flammeus. ( 29547139 )
2019
9
Large pregnancy-associated pyogenic granuloma: a case report. ( 29560775 )
2019
10
Pyogenic granuloma originating in the pulmonary artery. ( 29721848 )
2019
11
Efficacy of Nd-YAG laser for treatment of pyogenic granuloma on the fingers and toes. ( 29998355 )
2019
12
Pyogenic granuloma of the ampulla of Vater: unexpected cause of gastrointestinal bleeding. ( 30094594 )
2019
13
Gastric pyogenic granuloma arising from artificial ulcer scar created by endoscopic submucosal dissection. ( 30314945 )
2019
14
Multifocal congenital pyogenic granuloma successfully treated with oral propranolol. ( 30318648 )
2019
15
Therapeutic approaches to pyogenic granuloma: an updated review. ( 30345507 )
2019
16
Four cases of paradoxical cephalocervical pyogenic granuloma during treatment with paclitaxel and ramucirumab. ( 30379358 )
2019
17
Pyogenic granuloma of the larynx: A rare cause of hemoptysis. ( 30514577 )
2019
18
Cutaneous metastasis from breast carcinoma clinically mimicking pyogenic granuloma. ( 30616336 )
2019
19
Pyogenic granuloma over the venous component of a mixed vascular malformation. ( 30666667 )
2019
20
Bleeding pyogenic granuloma of the ampulla of Vater: a rare cause of severe chronic anemia. ( 30677391 )
2019
21
Pyogenic granuloma associated with conjunctival epithelial neoplasia: report of nine cases. ( 30709809 )
2019
22
Orocutaneous fistulas of odontogenic origin presenting as a recurrent pyogenic granuloma. ( 30727708 )
2019
23
Infected conjunctival pyogenic granuloma at strabismus surgery site mimicking conjunctival abscess. ( 30930675 )
2019
24
An unusual presentation of a pyogenic granuloma in a paediatric patient. ( 30957330 )
2019
25
Trap technique for bloodless removal of digital pyogenic granuloma. ( 30991123 )
2019
26
Pyogenic granuloma of the duodenum as an unusual cause of gastrointestinal bleeding. ( 31021165 )
2019
27
Expression of Components of the Renin-Angiotensin System in Pyogenic Granuloma. ( 31024924 )
2019
28
Pyogenic Granuloma of the Retina: A Case Series. ( 31049324 )
2019
29
Congenital cutaneous pyogenic granuloma: report of two cases and review of the literature. ( 31095756 )
2019
30
Lobular capillary hemangioma of the mandible: A case report. ( 29704808 )
2018
31
Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass. ( 29854524 )
2018
32
A Rare Cause of Resistant Epistaxis: Lobular Capillary Hemangioma Arising from the Inferior Turbinate. ( 29988261 )
2018
33
Intranasal Lobular Capillary Hemangioma with Multiple Sites of Origin during Pregnancy: A Case Report and Literature Review. ( 30319828 )
2018
34
Peripheral Ameloblastic Fibroma of Anterior Maxillary Gingiva Simulating Pyogenic Granuloma. ( 29950270 )
2018
35
A challenging diagnosis: Case report of oral metastasis from gastric adenocarcinoma mimicking pyogenic granuloma. ( 29595701 )
2018
36
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. ( 29561329 )
2018
37
Topical betaxolol for treating relapsing paronychia with pyogenic granuloma-like lesions induced by epidermal growth factor receptor inhibitors. ( 29339238 )
2018
38
Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma. ( 30258794 )
2018
39
Pyogenic granuloma of the penis following chancre. ( 28850727 )
2018
40
Intravenous lobular capillary haemangioma (pyogenic granuloma): A case report and a review of imaging findings as reported in the literature. ( 28861947 )
2018
41
Periungual pyogenic granuloma-like lesions following plaster cast immobilization: a case managed with symptomatic therapy. ( 28985457 )
2018
42
Extragingival Pregnancy Pyogenic Granuloma on the Lip. ( 29040143 )
2018
43
Combination of ligation and timolol before surgical excision of pyogenic granuloma. ( 29307642 )
2018
44
Pyogenic granuloma: A tumor that mimics infection. ( 29369925 )
2018
45
Pyogenic Granuloma of the Jejunum: an Unusual Cause of Anemia. ( 29374349 )
2018
46
No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma. ( 29406329 )
2018
47
Photodynamic therapy for periungual pyogenic granuloma-like during chemotherapy: our preliminary results. ( 29429004 )
2018
48
Pyogenic granuloma-like Kaposi's sarcoma on the first toe. ( 29446122 )
2018
49
Ureteric pyogenic granuloma: A peculiar case of ureteric obstruction. ( 29511640 )
2018
50
Patient Perspectives: What is a pyogenic granuloma? ( 29575073 )
2018

Variations for Pyogenic Granuloma

ClinVar genetic disease variations for Pyogenic Granuloma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GNA14 NM_004297.3(GNA14): c.614A> T (p.Gln205Leu) single nucleotide variant Likely pathogenic rs1554685903 GRCh37 Chromosome 9, 80043932: 80043932
2 GNA14 NM_004297.3(GNA14): c.614A> T (p.Gln205Leu) single nucleotide variant Likely pathogenic rs1554685903 GRCh38 Chromosome 9, 77429016: 77429016

Expression for Pyogenic Granuloma

Search GEO for disease gene expression data for Pyogenic Granuloma.

Pathways for Pyogenic Granuloma

Pathways related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 ANGPT1 ANGPT2 KRAS NRAS TEK
2
Show member pathways
13.35 ANGPT1 ANGPT2 KRAS NRAS TEK
3
Show member pathways
13.16 ANGPT1 ANGPT2 KRAS NRAS TEK
4
Show member pathways
13.07 ANGPT1 KRAS NRAS TEK
5
Show member pathways
13.02 ANGPT1 ANGPT2 KRAS NRAS TEK
6
Show member pathways
12.93 ANGPT1 ANGPT2 KRAS NRAS TEK
7
Show member pathways
12.87 ANGPT1 ANGPT2 KRAS NRAS TEK
8
Show member pathways
12.55 ANGPT1 ANGPT2 KRAS NRAS TEK
9 12.32 ANGPT1 ANGPT2 KRAS NRAS TEK
10
Show member pathways
12.2 ANGPT1 ANGPT2 KRAS NRAS TEK
11
Show member pathways
12.15 KRAS NRAS TEK
12
Show member pathways
11.95 KRAS NRAS TEK
13
Show member pathways
11.89 ANGPT1 ANGPT2 KRAS NRAS TEK
14 11.84 KRAS NRAS TEK
15
Show member pathways
11.68 ANGPT1 ANGPT2 KRAS NRAS
16 11.61 ANGPT1 ANGPT2 TEK
17
Show member pathways
11.6 KRAS NRAS
18 11.54 KRAS NRAS
19 11.48 KRAS NRAS
20 11.48 KRAS NRAS
21
Show member pathways
11.47 KRAS NRAS
22 11.43 KRAS NRAS
23 11.4 KRAS NRAS
24 11.32 KRAS NRAS
25 11.27 KRAS NRAS
26
Show member pathways
11.27 ANGPT1 ANGPT2 KRAS NRAS TEK
27 11.2 ANGPT1 TEK
28 11.19 ANGPT1 ANGPT2
29 11.15 KRAS NRAS
30 11.08 KRAS NRAS
31 11.08 KRAS NRAS
32
Show member pathways
11.05 KRAS NRAS
33
Show member pathways
10.99 KRAS NRAS
34 10.95 ANGPT1 TEK
35 10.92 KRAS NRAS
36 10.89 KRAS NRAS
37 10.84 KRAS NRAS
38 10.61 KRAS NRAS
39 10.1 ANGPT1 TEK

GO Terms for Pyogenic Granuloma

Cellular components related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 9.26 ACTC1 TEK
2 microvillus GO:0005902 9.16 ANGPT1 TEK
3 focal adhesion GO:0005925 9.13 ACTC1 KRAS TEK
4 membrane raft GO:0045121 8.8 ANGPT1 KRAS TEK

Biological processes related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of endothelial cell proliferation GO:0001938 9.51 NRAS TEK
2 angiogenesis GO:0001525 9.5 ANGPT1 ANGPT2 TEK
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.49 ANGPT1 TEK
4 Ras protein signal transduction GO:0007265 9.48 KRAS NRAS
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.46 KRAS NRAS
6 MAPK cascade GO:0000165 9.46 ANGPT1 KRAS NRAS TEK
7 positive regulation of endothelial cell migration GO:0010595 9.43 ANGPT1 TEK
8 leukocyte migration GO:0050900 9.43 ANGPT1 ANGPT2 TEK
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 ANGPT1 TEK
10 sprouting angiogenesis GO:0002040 9.37 ANGPT1 TEK
11 glomerulus vasculature development GO:0072012 9.13 ANGPT1 ANGPT2 TEK
12 Tie signaling pathway GO:0048014 8.8 ANGPT1 ANGPT2 TEK

Molecular functions related to Pyogenic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.13 KRAS NRAS TEK
2 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Pyogenic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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