Pyometritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pyometritis

MalaCards integrated aliases for Pyometritis:

Name: Pyometritis ¹¹ ¹⁴ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050862

UMLS ⁷¹ C0686163

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Summaries for Pyometritis

Disease Ontology: ¹¹ A uterine disease that is characterized by inflammation of the uterus and is associated with pus in the uterine cavity.

MalaCards based summary: Pyometritis is related to progressive non-infectious anterior vertebral fusion and breast lobular carcinoma. An important gene associated with Pyometritis is DNAJC1 (DnaJ Heat Shock Protein Family (Hsp40) Member C1), and among its related pathways/superpathways are Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) and Mammary gland development pathway - Puberty (Stage 2 of 4). Affiliated tissues include uterus, and related phenotypes are neoplasm and integument

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Related Diseases for Pyometritis

Diseases related to Pyometritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Related Disease	Score	Top Affiliating Genes
1	progressive non-infectious anterior vertebral fusion	10.1
2	breast lobular carcinoma	10.1	TBX3 PGR
3	lipid-rich breast carcinoma	10.0	PRL PGR
4	inappropriate adh syndrome	10.0	PRL LGI1
5	vallecula cancer	10.0	BMI1 AREG
6	breast abscess	10.0	PRL PGR
7	microglandular adenosis	10.0	PRL PGR
8	breast adenoma	10.0	PRL PGR
9	diffuse peritoneal leiomyomatosis	10.0	PGR GNRH1
10	leiomyomatosis	10.0	PGR GNRH1
11	peritoneal benign neoplasm	10.0	PGR GNRH1
12	premenstrual tension	10.0	PGR GNRH1
13	thoracic benign neoplasm	10.0	PRL PGR
14	nephrolithiasis, calcium oxalate	10.0
15	breast benign neoplasm	10.0	PRL PGR
16	adhesions of uterus	10.0	PGR GNRH1
17	prolapse of urethra	10.0	PGR GNRH1
18	adenomyoma	10.0	PGR GNRH1
19	leydig cell hypoplasia type ii	9.9	PRL GNRH1
20	mixed cerebral palsy	9.9	PRL GNRH1
21	rete ovarii adenoma	9.9	PRL GNRH1
22	rete ovarii benign neoplasm	9.9	PRL GNRH1
23	hypothalamic disease	9.9	PRL GNRH1
24	submucous uterine fibroid	9.9	PRL GNRH1
25	salpingitis isthmica nodosa	9.9	PRL GNRH1
26	sexual health disorder	9.9	PRL GNRH1
27	pituitary apoplexy	9.9	PRL GNRH1
28	van maldergem syndrome 1	9.9	PRL GNRH1
29	empty sella syndrome	9.9	PRL GNRH1
30	endometriosis of ovary	9.9	PGR GNRH1
31	steroid inherited metabolic disorder	9.9	PRL GNRH1
32	central diabetes insipidus	9.9	PRL GNRH1
33	aromatase excess syndrome	9.9	PGR GNRH1
34	pituitary hormone deficiency, combined, 2	9.9	PRL GNRH1
35	endogenous depression	9.9	PRL GNRH1
36	pelvic varices	9.8	PRL GNRH1
37	sebaceous gland disease	9.8	PRL GNRH1
38	ceroid lipofuscinosis, neuronal, 3	9.8	SULT1A3 HP
39	leydig cell tumor	9.8	PRL GNRH1
40	mixed cell adenoma	9.8	PRL GNRH1 AREG
41	polyp of corpus uteri	9.7	PRL PGR GNRH1
42	estrogen excess	9.7	PRL PGR GNRH1
43	ovarian cyst	9.7	PRL PGR GNRH1
44	premature ovarian failure 1	9.7	PRL GNRH1
45	uterine benign neoplasm	9.7	PRL PGR GNRH1
46	reproductive organ benign neoplasm	9.7	PRL PGR GNRH1
47	gynecomastia	9.7	PRL PGR GNRH1
48	amelogenesis imperfecta, type ig	9.7	PRL PGR GNRH1
49	amelogenesis imperfecta	9.7	PRL PGR GNRH1
50	priapism	9.7	HP GNRH1

Graphical network of the top 20 diseases related to Pyometritis:

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Symptoms & Phenotypes for Pyometritis

MGI Mouse Phenotypes related to Pyometritis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.35	BMI1 GNRH1 HP PGR PRL
2	integument	MP:0010771	9.1	AREG GNRH1 LGI1 PGR PRL TBX3

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Drugs & Therapeutics for Pyometritis

Search Clinical Trials, NIH Clinical Center for Pyometritis

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Genetic Tests for Pyometritis

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Anatomical Context for Pyometritis

Organs/tissues related to Pyometritis:

MalaCards : Uterus

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Publications for Pyometritis

Articles related to Pyometritis:

(show all 18)

#	Title	Authors	PMID	Year
1	Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain. ⁶²	Pandey J...Wendell DL	16284802	2005
2	Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5. ⁶²	Gould KA...Shull JD	16284801	2005
3	Microbiology and management of polymicrobial female genital tract infections in adolescents. ⁶²	Brook I	12459228	2002
4	Investigation of association between alpha-1 proteinase inhibitor haplotype and endometritis in the thoroughbred mare. ⁶²	Pemberton AD...Scott AM	8575373	1994
5	Interrelationships between postpartum events, hormonal therapy, reproductive abnormalities and reproductive performance in dairy cows: a path analysis. ⁶²	Etherington WG...Bosu WT	3899335	1985
6	Prostaglandin therapeutics in the bitch and queen. ⁶²	Henderson RT	6596937	1984
7	[Prolonged fever and latent tuberculous foci]. ⁶²	Weiller PJ...Mongin M	6261383	1981
8	Synergism of diethylstilbestrol and radiation in mammary carcinogenesis in female F344 rats. ⁶²	Holtzman S...Shellabarger CJ	480380	1979
9	Dinoprost in pyometritis in the bitch. ⁶²	Coulson A	556225	1979
10	Dinoprost in pyometritis in the bitch. ⁶²	Swift GA...Nuttall JE	555123	1979
11	Clinical, morphologic, and clinicopathologic findings in Beagles treated for two years with melengestrol acetate. ⁶²	Goyings LS...Geng S	596689	1977
12	A case of pyometritis in an East African de Brazza's monkey (Cercopithecus neglectus). ⁶²	Cooper JE	4630568	1972
13	Pyometritis in spayed cats. ⁶²	Long RD	5047568	1972
14	Pyometritis in a spayed cat. ⁶²	Wilkins DB	5047565	1972
15	Pyometritis in spayed cats. ⁶²	Orhan UA	5073599	1972
16	Pyometritis in spayed cats. ⁶²	Teale ML	5073604	1972
17	Renal calculus in association with pyometritis. ⁶²	Pollock S	6067872	1967
18	[Clinical diagnosis of pyometritis in bitches]. ⁶²	Arbeiter K	6013110	1966

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Genes for Pyometritis

Genes related to Pyometritis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DNAJC1	DnaJ Heat Shock Protein Family (Hsp40) Member C1	Protein Coding	5.69	DISEASES inferred ¹⁴
2	LSP1	Lymphocyte Specific Protein 1	Protein Coding	4.96	DISEASES inferred ¹⁴
3	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	4.81	DISEASES inferred ¹⁴
4	TBX3	T-Box Transcription Factor 3	Protein Coding	4.45	DISEASES inferred ¹⁴
5	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	4.15	DISEASES inferred ¹⁴
6	AREG	Amphiregulin	Protein Coding	3.78	DISEASES inferred ¹⁴
7	PGR	Progesterone Receptor	Protein Coding	3.69	DISEASES inferred ¹⁴
8	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	3.54	DISEASES inferred ¹⁴
9	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	3.47	DISEASES inferred ¹⁴
10	HP	Haptoglobin	Protein Coding	3.37	DISEASES inferred ¹⁴
11	PRL	Prolactin	Protein Coding	3.19	DISEASES inferred ¹⁴

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Variations for Pyometritis

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Expression for Pyometritis

Search GEO for disease gene expression data for Pyometritis.

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Pathways for Pyometritis

Pathways related to Pyometritis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	10.46	PRL PGR
2	Mammary gland development pathway - Puberty (Stage 2 of 4) ⁷⁴	9.74	PGR AREG

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GO Terms for Pyometritis

Biological processes related to Pyometritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mammary gland development	GO:0030879	9.02	TBX3 PRL PGR

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Sources for Pyometritis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PYM002 MIFTS: 20	Pyometritis Categories: Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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