MCID: PYM002
MIFTS: 20

Pyometritis

Categories: Reproductive diseases
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Aliases & Classifications for Pyometritis

MalaCards integrated aliases for Pyometritis:

Name: Pyometritis 11 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:0050862
UMLS 71 C0686163

Summaries for Pyometritis

Disease Ontology: 11 A uterine disease that is characterized by inflammation of the uterus and is associated with pus in the uterine cavity.

MalaCards based summary: Pyometritis is related to progressive non-infectious anterior vertebral fusion and breast lobular carcinoma. An important gene associated with Pyometritis is DNAJC1 (DnaJ Heat Shock Protein Family (Hsp40) Member C1), and among its related pathways/superpathways are Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) and Mammary gland development pathway - Puberty (Stage 2 of 4). Affiliated tissues include uterus, and related phenotypes are neoplasm and integument

Related Diseases for Pyometritis

Diseases related to Pyometritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 progressive non-infectious anterior vertebral fusion 10.1
2 breast lobular carcinoma 10.1 TBX3 PGR
3 lipid-rich breast carcinoma 10.0 PRL PGR
4 inappropriate adh syndrome 10.0 PRL LGI1
5 vallecula cancer 10.0 BMI1 AREG
6 breast abscess 10.0 PRL PGR
7 microglandular adenosis 10.0 PRL PGR
8 breast adenoma 10.0 PRL PGR
9 diffuse peritoneal leiomyomatosis 10.0 PGR GNRH1
10 leiomyomatosis 10.0 PGR GNRH1
11 peritoneal benign neoplasm 10.0 PGR GNRH1
12 premenstrual tension 10.0 PGR GNRH1
13 thoracic benign neoplasm 10.0 PRL PGR
14 nephrolithiasis, calcium oxalate 10.0
15 breast benign neoplasm 10.0 PRL PGR
16 adhesions of uterus 10.0 PGR GNRH1
17 prolapse of urethra 10.0 PGR GNRH1
18 adenomyoma 10.0 PGR GNRH1
19 leydig cell hypoplasia type ii 9.9 PRL GNRH1
20 mixed cerebral palsy 9.9 PRL GNRH1
21 rete ovarii adenoma 9.9 PRL GNRH1
22 rete ovarii benign neoplasm 9.9 PRL GNRH1
23 hypothalamic disease 9.9 PRL GNRH1
24 submucous uterine fibroid 9.9 PRL GNRH1
25 salpingitis isthmica nodosa 9.9 PRL GNRH1
26 sexual health disorder 9.9 PRL GNRH1
27 pituitary apoplexy 9.9 PRL GNRH1
28 van maldergem syndrome 1 9.9 PRL GNRH1
29 empty sella syndrome 9.9 PRL GNRH1
30 endometriosis of ovary 9.9 PGR GNRH1
31 steroid inherited metabolic disorder 9.9 PRL GNRH1
32 central diabetes insipidus 9.9 PRL GNRH1
33 aromatase excess syndrome 9.9 PGR GNRH1
34 pituitary hormone deficiency, combined, 2 9.9 PRL GNRH1
35 endogenous depression 9.9 PRL GNRH1
36 pelvic varices 9.8 PRL GNRH1
37 sebaceous gland disease 9.8 PRL GNRH1
38 ceroid lipofuscinosis, neuronal, 3 9.8 SULT1A3 HP
39 leydig cell tumor 9.8 PRL GNRH1
40 mixed cell adenoma 9.8 PRL GNRH1 AREG
41 polyp of corpus uteri 9.7 PRL PGR GNRH1
42 estrogen excess 9.7 PRL PGR GNRH1
43 ovarian cyst 9.7 PRL PGR GNRH1
44 premature ovarian failure 1 9.7 PRL GNRH1
45 uterine benign neoplasm 9.7 PRL PGR GNRH1
46 reproductive organ benign neoplasm 9.7 PRL PGR GNRH1
47 gynecomastia 9.7 PRL PGR GNRH1
48 amelogenesis imperfecta, type ig 9.7 PRL PGR GNRH1
49 amelogenesis imperfecta 9.7 PRL PGR GNRH1
50 priapism 9.7 HP GNRH1

Graphical network of the top 20 diseases related to Pyometritis:



Diseases related to Pyometritis

Symptoms & Phenotypes for Pyometritis

MGI Mouse Phenotypes related to Pyometritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 BMI1 GNRH1 HP PGR PRL
2 integument MP:0010771 9.1 AREG GNRH1 LGI1 PGR PRL TBX3

Drugs & Therapeutics for Pyometritis

Search Clinical Trials, NIH Clinical Center for Pyometritis

Genetic Tests for Pyometritis

Anatomical Context for Pyometritis

Organs/tissues related to Pyometritis:

MalaCards : Uterus

Publications for Pyometritis

Articles related to Pyometritis:

(show all 18)
# Title Authors PMID Year
1
Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain. 62
16284802 2005
2
Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5. 62
16284801 2005
3
Microbiology and management of polymicrobial female genital tract infections in adolescents. 62
12459228 2002
4
Investigation of association between alpha-1 proteinase inhibitor haplotype and endometritis in the thoroughbred mare. 62
8575373 1994
5
Interrelationships between postpartum events, hormonal therapy, reproductive abnormalities and reproductive performance in dairy cows: a path analysis. 62
3899335 1985
6
Prostaglandin therapeutics in the bitch and queen. 62
6596937 1984
7
[Prolonged fever and latent tuberculous foci]. 62
6261383 1981
8
Synergism of diethylstilbestrol and radiation in mammary carcinogenesis in female F344 rats. 62
480380 1979
9
Dinoprost in pyometritis in the bitch. 62
556225 1979
10
Dinoprost in pyometritis in the bitch. 62
555123 1979
11
Clinical, morphologic, and clinicopathologic findings in Beagles treated for two years with melengestrol acetate. 62
596689 1977
12
A case of pyometritis in an East African de Brazza's monkey (Cercopithecus neglectus). 62
4630568 1972
13
Pyometritis in spayed cats. 62
5047568 1972
14
Pyometritis in a spayed cat. 62
5047565 1972
15
Pyometritis in spayed cats. 62
5073599 1972
16
Pyometritis in spayed cats. 62
5073604 1972
17
Renal calculus in association with pyometritis. 62
6067872 1967
18
[Clinical diagnosis of pyometritis in bitches]. 62
6013110 1966

Variations for Pyometritis

Expression for Pyometritis

Search GEO for disease gene expression data for Pyometritis.

Pathways for Pyometritis

Pathways related to Pyometritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.46 PRL PGR
2 9.74 PGR AREG

GO Terms for Pyometritis

Biological processes related to Pyometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mammary gland development GO:0030879 9.02 TBX3 PRL PGR

Sources for Pyometritis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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