Pyometritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pyometritis

MalaCards integrated aliases for Pyometritis:

Name: Pyometritis ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050862

UMLS ⁷⁰ C0686163

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Summaries for Pyometritis

Disease Ontology : ¹² A uterine disease that is characterized by inflammation of the uterus and is associated with pus in the uterine cavity.

MalaCards based summary : Pyometritis is related to luminal breast carcinoma b and vallecula cancer. An important gene associated with Pyometritis is DNAJC1 (DnaJ Heat Shock Protein Family (Hsp40) Member C1). Affiliated tissues include uterus, and related phenotype is integument.

Wikipedia : ⁷³ Pyometra or pyometritis is a uterine infection. Though it is most commonly known as a disease of the... more...

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Related Diseases for Pyometritis

Diseases related to Pyometritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)

#	Related Disease	Score	Top Affiliating Genes
1	luminal breast carcinoma b	10.1	TBX3 PGR
2	vallecula cancer	10.1	BMI1 AREG
3	mixed cell adenoma	10.1	GNRH1 AREG
4	juvenile nasopharyngeal angiofibroma	10.0	PGR BMI1
5	diffuse peritoneal leiomyomatosis	10.0	PGR GNRH1
6	peritoneal benign neoplasm	10.0	PGR GNRH1
7	premenstrual tension	10.0	PGR GNRH1
8	adenomyoma	10.0	PGR GNRH1
9	endometriosis of ovary	9.9	PGR GNRH1
10	vulvar benign neoplasm	9.9	PGR HP
11	ovarian endometrial cancer	9.9	PGR HP
12	priapism	9.9	HP GNRH1
13	lipid-rich breast carcinoma	9.9	PRL PGR
14	breast adenoma	9.8	PRL PGR
15	pituitary infarct	9.8	PRL GNRH1
16	mixed cerebral palsy	9.8	PRL GNRH1
17	intracystic papillary adenoma	9.8	PRL PGR
18	hypothalamic disease	9.8	PRL GNRH1
19	endometritis	9.8	PGR HP
20	pituitary apoplexy	9.8	PRL GNRH1
21	empty sella syndrome	9.8	PRL GNRH1
22	van maldergem syndrome 1	9.8	PRL GNRH1
23	steroid inherited metabolic disorder	9.8	PRL GNRH1
24	pelvic varices	9.8	PRL GNRH1
25	thoracic benign neoplasm	9.8	PRL PGR
26	breast benign neoplasm	9.8	PRL PGR
27	diabetes insipidus, neurohypophyseal	9.7	PRL GNRH1
28	melancholia	9.7	PRL HP
29	ovarian cyst	9.7	PRL GNRH1
30	vaginal discharge	9.7	PGR HP GNRH1
31	sebaceous gland disease	9.7	PRL GNRH1
32	endometrial disease	9.7	PGR HP GNRH1
33	endogenous depression	9.7	PRL GNRH1
34	sexual disorder	9.6	PRL GNRH1
35	estrogen excess	9.6	PRL PGR GNRH1
36	uterine benign neoplasm	9.6	PRL PGR GNRH1
37	reproductive organ benign neoplasm	9.6	PRL PGR GNRH1
38	adenomyosis	9.6	PRL PGR GNRH1
39	leydig cell tumor	9.6	PRL GNRH1
40	gynecomastia	9.6	PRL PGR GNRH1
41	amelogenesis imperfecta, type ig	9.6	PRL PGR GNRH1
42	amelogenesis imperfecta	9.6	PRL PGR GNRH1
43	anovulation	9.5	PRL HP GNRH1
44	ovarian disease	9.2	PRL PGR GNRH1

Graphical network of the top 20 diseases related to Pyometritis:

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Symptoms & Phenotypes for Pyometritis

MGI Mouse Phenotypes related to Pyometritis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.1	AREG GNRH1 LGI1 PGR PRL TBX3

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Drugs & Therapeutics for Pyometritis

Search Clinical Trials , NIH Clinical Center for Pyometritis

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Genetic Tests for Pyometritis

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Anatomical Context for Pyometritis

MalaCards organs/tissues related to Pyometritis:

⁴⁰

Uterus

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Publications for Pyometritis

Articles related to Pyometritis:

(show all 18)

#	Title	Authors	PMID	Year
1	Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5. ⁶¹	Gould KA...Shull JD	16284801	2005
2	Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain. ⁶¹	Pandey J...Wendell DL	16284802	2005
3	Microbiology and management of polymicrobial female genital tract infections in adolescents. ⁶¹	Brook I	12459228	2002
4	Investigation of association between alpha-1 proteinase inhibitor haplotype and endometritis in the thoroughbred mare. ⁶¹	Pemberton AD...Scott AM	8575373	1994
5	Interrelationships between postpartum events, hormonal therapy, reproductive abnormalities and reproductive performance in dairy cows: a path analysis. ⁶¹	Etherington WG...Bosu WT	3899335	1985
6	Prostaglandin therapeutics in the bitch and queen. ⁶¹	Henderson RT	6596937	1984
7	[Prolonged fever and latent tuberculous foci]. ⁶¹	Weiller PJ...Mongin M	6261383	1981
8	Synergism of diethylstilbestrol and radiation in mammary carcinogenesis in female F344 rats. ⁶¹	Holtzman S...Shellabarger CJ	480380	1979
9	Dinoprost in pyometritis in the bitch. ⁶¹	Coulson A	556225	1979
10	Dinoprost in pyometritis in the bitch. ⁶¹	Swift GA...Nuttall JE	555123	1979
11	Clinical, morphologic, and clinicopathologic findings in Beagles treated for two years with melengestrol acetate. ⁶¹	Goyings LS...Geng S	596689	1977
12	A case of pyometritis in an East African de Brazza's monkey (Cercopithecus neglectus). ⁶¹	Cooper JE	4630568	1972
13	Pyometritis in spayed cats. ⁶¹	Long RD	5047568	1972
14	Pyometritis in spayed cats. ⁶¹	Teale ML	5073604	1972
15	Pyometritis in spayed cats. ⁶¹	Orhan UA	5073599	1972
16	Pyometritis in a spayed cat. ⁶¹	Wilkins DB	5047565	1972
17	Renal calculus in association with pyometritis. ⁶¹	Pollock S	6067872	1967
18	[Clinical diagnosis of pyometritis in bitches]. ⁶¹	Arbeiter K	6013110	1966

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Genes for Pyometritis

Genes related to Pyometritis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DNAJC1	DnaJ Heat Shock Protein Family (Hsp40) Member C1	Protein Coding	6.1	DISEASES inferred ¹⁵
2	LSP1	Lymphocyte Specific Protein 1	Protein Coding	5.34	DISEASES inferred ¹⁵
3	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	5.31	DISEASES inferred ¹⁵
4	TBX3	T-Box Transcription Factor 3	Protein Coding	4.9	DISEASES inferred ¹⁵
5	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	4.72	DISEASES inferred ¹⁵
6	AREG	Amphiregulin	Protein Coding	4.27	DISEASES inferred ¹⁵
7	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	4.02	DISEASES inferred ¹⁵
8	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	3.96	DISEASES inferred ¹⁵
9	HP	Haptoglobin	Protein Coding	3.85	DISEASES inferred ¹⁵
10	PRL	Prolactin	Protein Coding	3.64	DISEASES inferred ¹⁵
11	PGR	Progesterone Receptor	Protein Coding	3.29	DISEASES inferred ¹⁵

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Variations for Pyometritis

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Expression for Pyometritis

Search GEO for disease gene expression data for Pyometritis.

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Pathways for Pyometritis

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GO Terms for Pyometritis

Biological processes related to Pyometritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.13	PGR GNRH1 AREG
2	mammary gland development	GO:0030879	8.8	TBX3 PRL PGR

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Sources for Pyometritis

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