PM
MCID: PYM001
MIFTS: 45

Pyomyositis (PM)

Categories: Bone diseases, Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Pyomyositis

MalaCards integrated aliases for Pyomyositis:

Name: Pyomyositis 12 76 53 59 44 15 73
Tropical Pyomyositis 12 59 73
Myositis Purulenta Tropica 59
Suppurative Myositis 59
Myositis Tropicans 59
Purulent Myositis 73
Pm 59

Characteristics:

Orphanet epidemiological data:

59
pyomyositis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:876
ICD10 33 M60.0
ICD9CM 35 040.81
MeSH 44 D052880
NCIt 50 C128382
SNOMED-CT 68 65110003
Orphanet 59 ORPHA764
UMLS via Orphanet 74 C0041188 C1704275
MESH via Orphanet 45 D052880
ICD10 via Orphanet 34 M60.0

Summaries for Pyomyositis

NIH Rare Diseases : 53 Pyomyositis is rare bacterial infection of the skeletal muscle (the muscles used for movement). Signs and symptoms may include pain and tenderness of the affected muscle, fever, and abscess formation. If left untreated, the abscess may extend into the bone and joint or blood poisoning may occur. Approximately 90% of cases are caused by the bacterium, Staphylococcus aureus. Risk factors for the condition include strenuous activity, muscle trauma, skin infections, infected insect bites, illicit drug injections, connective tissue disorders, and diabetes. Treatment generally includes surgical drainage of the abscess and antibiotics.

MalaCards based summary : Pyomyositis, also known as tropical pyomyositis, is related to arthritis and osteomyelitis. An important gene associated with Pyomyositis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Development NOTCH1-mediated pathway for NF-KB activity modulation. The drugs Isoniazid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, bone and skin, and related phenotypes are sudden cardiac death and renal insufficiency

Wikipedia : 76 Pyomyositis, also known as tropical pyomyositis or myositis tropicans, is a bacterial infection of the... more...

Related Diseases for Pyomyositis

Diseases related to Pyomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 arthritis 10.4
2 osteomyelitis 10.3
3 septic arthritis 10.3
4 leukemia 10.2
5 diabetes mellitus 10.2
6 epidural abscess 10.2
7 acquired immunodeficiency syndrome 10.1
8 myositis 10.1
9 rheumatoid arthritis 10.1
10 compartment syndrome 10.1
11 scrub typhus 10.1 CRP GPT
12 systemic lupus erythematosus 10.1
13 lymphocytic leukemia 10.1
14 lemierre's syndrome 10.1
15 toxic shock syndrome 10.1
16 lupus erythematosus 10.1
17 analbuminemia 10.1 CRP GPT
18 pharyngitis 10.0 CRP SUCLG2
19 obstructive jaundice 10.0 CRP GPT
20 cholangitis 10.0 CRP GPT
21 myeloma, multiple 10.0
22 aplastic anemia 10.0
23 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
24 endocarditis 10.0
25 viral infectious disease 10.0
26 fasciitis 10.0
27 necrotizing fasciitis 10.0
28 intestinal disease 10.0 CRP SIL1
29 breast cancer 9.9
30 acute lymphocytic leukemia 9.9
31 hepatitis 9.9
32 neutropenia 9.9
33 thrombosis 9.9
34 cellulitis 9.9
35 human immunodeficiency virus infectious disease 9.9
36 pneumonia 9.9
37 myeloid leukemia 9.9
38 meningitis 9.9
39 bacterial myositis 9.9
40 subclavian steal syndrome 9.9 CRP NOTCH1
41 hypercholesterolemia, familial 9.9 CRP GPT
42 granulomatous angiitis 9.9 CRP NOTCH1
43 aortic disease 9.9 CRP NOTCH1
44 mouth disease 9.9 CRP NOTCH1
45 thrombophilia due to thrombin defect 9.9
46 endometrial cancer 9.9
47 diabetes mellitus, ketosis-prone 9.9
48 leukemia, acute lymphoblastic 9.9
49 chronic granulomatous disease 9.9
50 dermatomyositis 9.9

Graphical network of the top 20 diseases related to Pyomyositis:



Diseases related to Pyomyositis

Symptoms & Phenotypes for Pyomyositis

Human phenotypes related to Pyomyositis:

59 32 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sudden cardiac death 59 32 occasional (7.5%) Occasional (29-5%) HP:0001645
2 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
3 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
4 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
5 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
6 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
7 leukocytosis 59 32 frequent (33%) Frequent (79-30%) HP:0001974
8 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
9 recurrent cutaneous abscess formation 59 32 hallmark (90%) Very frequent (99-80%) HP:0100838
10 myositis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100614
11 testicular teratoma 59 32 frequent (33%) Frequent (79-30%) HP:0100616
12 recurrent infections 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Pyomyositis according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.64 CRP NONO NOTCH1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.64 NONO NOTCH1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.64 CRP NOTCH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.64 NONO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.64 CRP NOTCH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.64 NONO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 NONO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.64 NOTCH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.64 NONO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 NOTCH1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NONO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.64 CRP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.64 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 CRP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.64 NOTCH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.64 NONO

Drugs & Therapeutics for Pyomyositis

Drugs for Pyomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2 Anti-Bacterial Agents Phase 3
3 Lipid Regulating Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Antimetabolites Phase 3
6 Hypolipidemic Agents Phase 3
7 Antitubercular Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
2 Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections Not yet recruiting NCT03802552 Phase 1 Cefadroxil;Cephalexin

Search NIH Clinical Center for Pyomyositis

Cochrane evidence based reviews: pyomyositis

Genetic Tests for Pyomyositis

Anatomical Context for Pyomyositis

MalaCards organs/tissues related to Pyomyositis:

41
Skeletal Muscle, Bone, Skin, Myeloid, Bone Marrow, Liver, Spinal Cord

Publications for Pyomyositis

Articles related to Pyomyositis:

(show top 50) (show all 671)
# Title Authors Year
1
Pyomyositis and osteomyelitis: an unusual cause of abdominal pain. ( 29559487 )
2018
2
Pyomyositis: an unusual cause of hip pain in a patient on certolizumab pegol and leflunomide. ( 29660056 )
2018
3
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )
2018
4
Pyomyositis presenting as septic arthritis. ( 29559212 )
2018
5
Pyomyositis in the setting of complicated diverticulitis: case report. ( 29317845 )
2018
6
Group A Streptococcal Pyomyositis in a Previously Healthy Six-year-old Girl. ( 29644156 )
2018
7
Gram-Negative Pyomyositis in an Immunocompetent Patient. ( 29888157 )
2018
8
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
9
Subscapularis pyomyositis: a rare presentation of shoulder pain. ( 29549135 )
2018
10
Combined Labeled Leukocyte and Technicium 99 Sulfur Colloid Bone Marrow Imaging: Differentiating Primary Pyomyositis Pseudotumor from Osteomyelitis and Multiple Bone Infarcts. ( 29772988 )
2018
11
<i>Candida albicans</i> Pyomyositis in a Patient with Systemic Lupus Erythematosus. ( 29419450 )
2018
12
Abdominal rectus muscle pyomyositis: Report of a case and review of the literature. ( 29721242 )
2018
13
Primary pyomyositis in North India: a clinical, microbiological, and outcome study. ( 29338140 )
2018
14
Concurrent methicillin-resistant Staphylococcus aureus septicemia and pyomyositis in a patient with dengue hemorrhagic fever: a case report. ( 29486726 )
2018
15
An Unusual Presentation of Pectoralis Major Pyomyositis Presenting as Septic Arthritis of the Shoulder: A Case Report and Review of the Literature. ( 30423796 )
2018
16
Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis. ( 29657883 )
2018
17
Case of acute paraspinal pyomyositis in an elderly diabetic secondary to spread from urinary tract infection. ( 30139787 )
2018
18
Percutaneous transgluteal computed tomography-guided aspiration of obturator internus pyomyositis in adolescent athlete: A case report and literature review. ( 30233741 )
2018
19
Pyomyositis Diagnosed by Point-of-Care Ultrasound in the Emergency Department. ( 30274728 )
2018
20
Multiple pyomyositis secondary to septic thrombophlebitis. ( 30340839 )
2018
21
Pyomyositis secondary to prostatic abscesses. ( 30361055 )
2018
22
Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report. ( 29179775 )
2017
23
Pelvic pyomyositis in children: changing trends in occurrence and management. ( 29289987 )
2017
24
Bilateral Neck Pyomyositis Caused by<i>Staphylococcus capitis</i>and<i>Staphylococcus saccharolyticus</i>in a Diabetic Adult. ( 29109878 )
2017
25
Peculiar purulence: Hypervirulent Klebsiella pneumoniae causing pyomyositis. ( 29030138 )
2017
26
Tropical Pyomyositis: Revisited. ( 28331264 )
2017
27
Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. ( 28877155 )
2017
28
Pyomyositis of the pectineus muscle in an adolescent male. ( 28853599 )
2017
29
Point-of-care ultrasound in pyomyositis: A case series. ( 29046245 )
2017
30
Pyomyositis in a Patient with AIDS. ( 28626195 )
2017
31
Pyomyositis of Gluteus medius: A case report and review of the literature. ( 29181353 )
2017
32
Nocardial pyomyositis. ( 28298844 )
2017
33
Pyomyositis Complicated by Deep Venous Thrombosis - A Unique Case of Reverse Lemierre's Syndrome. ( 28462553 )
2017
34
Extraintestinal Salmonellosis in the Immunocompromised: An Unusual Case of Pyomyositis. ( 29081808 )
2017
35
Breakthrough fusariosis presenting initially with pyomyositis. ( 27914686 )
2017
36
<i>Streptococcus dysagalactiae</i> pyomyositis. ( 29264084 )
2017
37
Cellulitis and posterior cervical pyomyositis by Staphylococcus aureus methicillin resistant in diabetic patient. ( 29295786 )
2017
38
Haemophilus influenzae Pyomyositis in a Patient with Diabetic Ketoacidosis: A Unique Case and Review of Literature. ( 28352482 )
2017
39
Thigh pyomyositis caused by group A streptococcus in an immunocompetent adult without any cause. ( 28063458 )
2017
40
Panton-Valentine Leukocidin Producing Staphylococcus aureus Facial Pyomyositis Causing Partial Cavernous Sinus Thrombosis. ( 28640000 )
2017
41
The Brief Case: Anaerobiospirillum succiniciproducens Bacteremia and Pyomyositis. ( 28232502 )
2017
42
Primary pyomyositis in children. ( 29274860 )
2017
43
Salmonella pyomyositis with concurrent sacroiliac osteomyelitis presenting as piriformis syndrome: A rare case. ( 27779154 )
2017
44
Multifocal pyomyositis after intra-articular injections. ( 29264046 )
2017
45
Team Approach: Pyomyositis. ( 28654470 )
2017
46
Primary Tuberculous Pyomyositis of the Calf Muscles. ( 28183421 )
2017
47
Primary fusobacterium osteomyelitis and pyomyositis of the thigh in an immunocompetent young adult. ( 28876557 )
2017
48
Sonographic appearance of pyomyositis of the sternocleidomastoid muscle: A case report. ( 27874219 )
2017
49
Closing the Brief Case: Anaerobiospirillum succiniciproducens Bacteremia and Pyomyositis. ( 28232506 )
2017
50
Extensive pyomyositis of vastus muscles. ( 29138666 )
2017

Variations for Pyomyositis

Expression for Pyomyositis

Search GEO for disease gene expression data for Pyomyositis.

Pathways for Pyomyositis

Pathways related to Pyomyositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.85 NONO NOTCH1

GO Terms for Pyomyositis

Sources for Pyomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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