PM
MCID: PYM001
MIFTS: 42

Pyomyositis (PM)

Categories: Bone diseases, Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Pyomyositis

MalaCards integrated aliases for Pyomyositis:

Name: Pyomyositis 12 74 20 58 44 15 17 71
Tropical Pyomyositis 12 58 71
Myositis Purulenta Tropica 58
Suppurative Myositis 58
Myositis Tropicans 58
Purulent Myositis 71
Pm 58

Characteristics:

Orphanet epidemiological data:

58
pyomyositis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:876
ICD9CM 34 040.81
MeSH 44 D052880
NCIt 50 C128382
SNOMED-CT 67 186430009
ICD10 32 M60.0
MESH via Orphanet 45 D052880
ICD10 via Orphanet 33 M60.0
UMLS via Orphanet 72 C0041188 C1704275
Orphanet 58 ORPHA764
UMLS 71 C0041188 C0263979 C1704275

Summaries for Pyomyositis

GARD : 20 Pyomyositis is rare bacterial infection of the skeletal muscle (the muscles used for movement). Signs and symptoms may include pain and tenderness of the affected muscle, fever, and abscess formation. If left untreated, the abscess may extend into the bone and joint or blood poisoning may occur. Approximately 90% of cases are caused by the bacterium, Staphylococcus aureus. Risk factors for the condition include strenuous activity, muscle trauma, skin infections, infected insect bites, illicit drug injections, connective tissue disorders, and diabetes. Treatment generally includes surgical drainage of the abscess and antibiotics.

MalaCards based summary : Pyomyositis, also known as tropical pyomyositis, is related to epidural abscess and compartment syndrome. An important gene associated with Pyomyositis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Cytokines and Inflammatory Response. The drugs Cephalexin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, skin and bone marrow, and related phenotypes are fever and subcutaneous nodule

Wikipedia : 74 Pyomyositis, is a bacterial infection of the skeletal muscles which results in an abscess. Pyomyositis... more...

Related Diseases for Pyomyositis

Diseases related to Pyomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 epidural abscess 30.7 CRP CD4
2 compartment syndrome 30.5 PIK3C2A MB CRP
3 pleural empyema 30.3 CRP CD4
4 bacterial infectious disease 30.3 CSF3 CRP CD4
5 soft tissue sarcoma 30.3 CSF3 CRP
6 cardiac tamponade 30.2 PIK3C2A CRP
7 cellulitis 30.2 MYOM2 CSF3 CRP CD4
8 necrotizing fasciitis 30.1 TST MYOM2 CRP
9 ritter's disease 30.0 TST EDNRB
10 discitis 30.0 TST CRP
11 chickenpox 30.0 CRP CD4
12 gas gangrene 30.0 PIK3C2A MB CRP
13 parametritis 29.9 MB CRP
14 pericardial effusion 29.9 PIK3C2A CRP CD4
15 hypopyon 29.9 CRP CD4
16 tenosynovitis 29.9 CRP CD4
17 trichinosis 29.9 PIK3C2A CD4
18 pharyngitis 29.8 MYOM2 CRP CD4
19 actinomycosis 29.8 CRP CD4
20 klebsiella pneumonia 29.8 CRP CD4
21 bronchopneumonia 29.8 CRP CD4
22 disseminated intravascular coagulation 29.7 PIK3C2A MB CRP
23 panniculitis 29.7 CSF3 CRP CD4
24 pancytopenia 29.7 CSF3 CRP CD4
25 pyoderma 29.6 MYOM2 EDNRB CSF3
26 subacute bacterial endocarditis 29.6 SRA1 CRP
27 exanthem 29.5 PIK3C2A CSF3 CRP CD4
28 impetigo 29.4 TST MYOM2 EDNRB
29 dilated cardiomyopathy 28.8 SRA1 MB EDNRB CSF3 CRP
30 osteomyelitis 10.6
31 septic arthritis 10.6
32 myositis 10.5
33 toxic shock syndrome 10.4
34 orbital plasma cell granuloma 10.3 PIK3C2A CRP
35 chronic orbital inflammation 10.3 PIK3C2A CRP
36 ornithosis 10.3 PIK3C2A CRP
37 basidiobolomycosis 10.3 PIK3C2A CRP
38 acquired immunodeficiency syndrome 10.3
39 orbital granuloma 10.3 CSF3 CRP
40 neutrophilic dermatosis, acute febrile 10.3 CSF3 CRP
41 left bundle branch hemiblock 10.3 PIK3C2A CRP
42 neutrophilia, hereditary 10.3 CSF3 CRP
43 epidemic pleurodynia 10.3 PIK3C2A MB
44 virus associated hemophagocytic syndrome 10.3 PIK3C2A MB
45 spondylolisthesis 10.3 PIK3C2A CRP
46 interstitial myocarditis 10.3 PIK3C2A MB
47 anteroseptal myocardial infarction 10.3 PIK3C2A MB
48 staphyloenterotoxemia 10.3 TST EPHX2
49 coronary artery vasospasm 10.3 PIK3C2A CRP
50 aniseikonia 10.3 CSF3 CD4

Graphical network of the top 20 diseases related to Pyomyositis:



Diseases related to Pyomyositis

Symptoms & Phenotypes for Pyomyositis

Human phenotypes related to Pyomyositis:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
3 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
4 recurrent cutaneous abscess formation 58 31 hallmark (90%) Very frequent (99-80%) HP:0100838
5 myositis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100614
6 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
7 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
8 testicular teratoma 58 31 frequent (33%) Frequent (79-30%) HP:0100616
9 sudden cardiac death 58 31 occasional (7.5%) Occasional (29-5%) HP:0001645
10 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
11 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
12 recurrent infections 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Pyomyositis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 C5AR1 CD4 CRP CSF3 EDNRB PIK3C2A

Drugs & Therapeutics for Pyomyositis

Drugs for Pyomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cephalexin Approved, Investigational, Vet_approved Phase 1 15686-71-2 27447
2 Anti-Infective Agents Phase 1
3 Anti-Bacterial Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
2 Plasma-Based Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections Not yet recruiting NCT03846804

Search NIH Clinical Center for Pyomyositis

Cochrane evidence based reviews: pyomyositis

Genetic Tests for Pyomyositis

Anatomical Context for Pyomyositis

MalaCards organs/tissues related to Pyomyositis:

40
Skeletal Muscle, Skin, Bone Marrow, Kidney, Breast, Myeloid, Bone

Publications for Pyomyositis

Articles related to Pyomyositis:

(show top 50) (show all 1108)
# Title Authors PMID Year
1
Rapidly fatal tropical pyomyositis in a elderly diabetic woman. 61
33540127 2021
2
Combined approach for intrapelvic abscess drainage among adults. 61
33364294 2021
3
Improving Care and Outcomes for Pediatric Musculoskeletal Infections. 61
33414235 2021
4
Osteomyelitis and pyomyositis due to Staphylococcus aureus in an osteomalacic adult with multiple fractures. 61
33552424 2021
5
Neisseria gonorrhoeae pyomyositis complicated by compartment syndrome: A rare manifestation of disseminated gonococcal infection. 61
33294370 2021
6
Etiology, Characteristics, and Outcomes of Community-Onset Pyomyositis in Korea: A Multicenter Study. 61
33538131 2021
7
[Acute pyomyositis: diagnosis and treatment of 3 cases in a secondary hospital]. 61
33483242 2021
8
Hospital admissions for skin and soft tissue infections in a population with endemic scabies: A prospective study in Fiji, 2018-2019. 61
33296378 2020
9
Pseudomonas aeruginosa Pyomyositis in a Child With Acute Lymphoblastic Leukemia: A Case Report and Review of Literature. 61
33290294 2020
10
Long-Term Impact of a Clinical Care Guideline for Pediatric Acute Musculoskeletal Infections: Are Improved Outcomes Sustainable? 61
33154082 2020
11
Subscapularis pyomyositis presenting as shoulder stiffness mistaken as frozen shoulder in young female: a case report. 61
32944117 2020
12
Peritonitis and Pyomyositis Complicating Strep Pharyngitis. 61
33131280 2020
13
Methicillin Resistant Staphylococcus Aureus Shoulder Pyomyositis with Multifocal Lung Infiltrations. 61
33212753 2020
14
SONO case series: soft tissue infections, abscesses, pyomyositis and necrotising fasciitis. 61
32169882 2020
15
Candida albicans causing cervical pyomyositis: A case report. 61
32143841 2020
16
Septic emboli from pyomyositis. 61
32623976 2020
17
Piriformis Pyomyositis Presenting as Migratory Hip to Knee Pain: A Case Report. 61
33512936 2020
18
Aspergillus terreus septic arthritis and pyomyositis of shoulder. 61
33115625 2020
19
Extra-spinal sciatica and sciatica mimics: a scoping review. 61
32989195 2020
20
Protrusio acetabulae as a sequel to septic arthritis of the hip with obturator internus pyomyositis. 61
33136794 2020
21
Pyomyositis and muscle abscess due to Salmonella enteritidis in a patient with Behçet's syndrome: a case report. 61
33124570 2020
22
Histoplasma Pyomyositis in a Patient with Disseminated Histoplasmosis and Anti-Synthetase Syndrome: Case-Based Review of Literature. 61
33163869 2020
23
63-year-old man with right biceps and right pectoralis major abscesses: an unusual case of pyomyositis. 61
32928826 2020
24
How long should we treat Candida albicans pyomyositis? Insight from a cured case. 61
32107179 2020
25
Magnetic resonance imaging evaluation of posterior spinal tuberculosis: a cross-sectional study. 61
32799557 2020
26
Aggregatibacter actinomycetemcomitans Causing Empyema Necessitans and Pyomyositis in an Immunocompetent Patient. 61
32874788 2020
27
An unusual case of tropical pyomyositis: cryptococcal pyomyositis. 61
32487011 2020
28
Cervical Pyomyositis - A Rare Cause of Cervicalgia Presenting to the Emergency Room. 61
32127064 2020
29
Multifocal extraocular muscle pyomyositis: A case report and review of literature. 61
32515624 2020
30
Tropical pyomyositis: an update. 61
32219926 2020
31
Purulent infectious myositis (formerly tropical pyomyositis). 61
32172014 2020
32
Sonography of musculoskeletal infection in children. 61
32528546 2020
33
Pyomyositis in the United States 2002-2014. 61
32147332 2020
34
Pyomyositis presenting as septic arthritis. 61
29559212 2020
35
Tropical pyomyositis in a patient with hyperimmunoglobulin E syndrome. 61
32367854 2020
36
A case of paraspinal pyomyositis in a healthy young man. 61
32409344 2020
37
Pectoralis major muscle abscess in an immunocompromised adult: Case report and literature review. 61
32950948 2020
38
Discrimination between tuberculous and bacterial pyomyositis in magnetic resonance features. 61
33102635 2020
39
Pediatric Pyomyositis: A Rare but Important Complication of Varicella. 61
32158577 2020
40
Toxic shock syndrome and pyomyositis: about an unusual case. 61
32754290 2020
41
[Inflammatory myopathy following acute meningoccemia in a properdin-deficient patient: A case report]. 61
31735371 2020
42
[Pyomyositis due to Streptococcus pyogenes in a patient with venolymphatic malformation. Report of one pediatric case]. 61
31758910 2019
43
Pyomyositis secondary to prostatic abscesses. 61
30361055 2019
44
Diagnostic accuracy of 16S rDNA PCR in bacterial pyomyositis: A prospective study. 61
31430482 2019
45
Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children. 61
31567961 2019
46
An unusual clinical presentation of tuberculous pyomyositis in a renal allograft recipient. 61
31696860 2019
47
Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections. 61
31482119 2019
48
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. 61
31029399 2019
49
Piriformis pyomyositis, a cause of piriformis syndrome-a systematic search and review. 61
31049761 2019
50
Extensive pyomyositis of prevertebral muscles after acupuncture: Case report. 61
31321345 2019

Variations for Pyomyositis

Expression for Pyomyositis

Search GEO for disease gene expression data for Pyomyositis.

Pathways for Pyomyositis

Pathways related to Pyomyositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.09 CSF3 CD4

GO Terms for Pyomyositis

Biological processes related to Pyomyositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasoconstriction GO:0042310 8.62 EDNRB CRP

Sources for Pyomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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