PM
MCID: PYM001
MIFTS: 41

Pyomyositis (PM)

Categories: Bone diseases, Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Pyomyositis

MalaCards integrated aliases for Pyomyositis:

Name: Pyomyositis 12 74 52 58 43 15 17 71
Tropical Pyomyositis 12 58 71
Myositis Purulenta Tropica 58
Suppurative Myositis 58
Myositis Tropicans 58
Purulent Myositis 71
Pm 58

Characteristics:

Orphanet epidemiological data:

58
pyomyositis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:876
ICD9CM 34 040.81
MeSH 43 D052880
NCIt 49 C128382
SNOMED-CT 67 65110003
ICD10 32 M60.0
MESH via Orphanet 44 D052880
ICD10 via Orphanet 33 M60.0
UMLS via Orphanet 72 C0041188 C1704275
Orphanet 58 ORPHA764
UMLS 71 C0041188 C0263979 C1704275

Summaries for Pyomyositis

NIH Rare Diseases : 52 Pyomyositis is rare bacterial infection of the skeletal muscle (the muscles used for movement). Signs and symptoms may include pain and tenderness of the affected muscle, fever, and abscess formation. If left untreated, the abscess may extend into the bone and joint or blood poisoning may occur. Approximately 90% of cases are caused by the bacterium, Staphylococcus aureus . Risk factors for the condition include strenuous activity, muscle trauma, skin infections, infected insect bites, illicit drug injections, connective tissue disorders , and diabetes. Treatment generally includes surgical drainage of the abscess and antibiotics .

MalaCards based summary : Pyomyositis, also known as tropical pyomyositis, is related to epidural abscess and encephalopathy, progressive, early-onset, with episodic rhabdomyolysis. An important gene associated with Pyomyositis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Cytokines and Inflammatory Response. The drugs Cephalexin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and skin, and related phenotypes are fever and subcutaneous nodule

Wikipedia : 74 Pyomyositis, is a bacterial infection of the skeletal muscles which results in an abscess. Pyomyositis... more...

Related Diseases for Pyomyositis

Diseases related to Pyomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 epidural abscess 30.7 KAT8 CRP
2 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 30.6 PIK3C2A MB
3 bacterial infectious disease 30.6 CSF3 CRP CD4
4 pleural empyema 30.5 CRP CD4
5 compartment syndrome 30.5 PIK3C2A MB CRP
6 cardiac tamponade 30.4 PIK3C2A CRP
7 necrotizing fasciitis 30.4 TST SETBP1 CRP
8 hypopyon 30.3 CRP CD4
9 mastoiditis 30.2 CRP CD4
10 trichinosis 30.2 PIK3C2A CD4
11 discitis 30.2 TST CRP
12 pericardial effusion 30.2 PIK3C2A CRP CD4
13 bronchopneumonia 30.1 CRP CD4
14 gas gangrene 30.0 PIK3C2A MB CRP
15 pancytopenia 29.9 CSF3 CRP CD4
16 pneumonia 29.8 PIK3C2A MB CSF3 CRP
17 deficiency anemia 29.8 PIK3C2A MB CSF3 CRP
18 disseminated intravascular coagulation 29.7 PIK3C2A MB CRP
19 pyoderma 29.7 EDNRB CSF3 CRP
20 exanthem 29.7 PIK3C2A CSF3 CRP CD4
21 impetigo 29.4 TST EDNRB
22 ritter's disease 28.9 TST SETBP1 EPHX2 EDNRB
23 osteomyelitis 10.6
24 septic arthritis 10.6
25 myositis 10.5
26 ecthyma 10.5 CSF3 CRP
27 co-trimoxazole allergy 10.5 PIK3C2A CSF3
28 orbital plasma cell granuloma 10.5 PIK3C2A CRP
29 pericardial tuberculosis 10.4 CRP CD4
30 neuroretinitis 10.4 CRP CD4
31 breast abscess 10.4 CRP CD4
32 toxic shock syndrome 10.4
33 cellulitis 10.4
34 optic papillitis 10.4 CRP CD4
35 tertiary syphilis 10.4 CRP CD4
36 granulomatous hepatitis 10.4 CRP CD4
37 acute orbital inflammation 10.4 CRP CD4
38 opportunistic bacterial infectious disease 10.4 CRP CD4
39 gastrointestinal tuberculosis 10.4 CRP CD4
40 intestinal tuberculosis 10.4 CRP CD4
41 wissler's syndrome 10.4 CRP CD4
42 nocardiosis 10.4 CRP CD4
43 neurosarcoidosis 10.4 CRP CD4
44 mononeuritis of upper limb and mononeuritis multiplex 10.4 CRP CD4
45 mononeuritis multiplex 10.4 CRP CD4
46 acute interstitial pneumonia 10.4 CRP CD4
47 cat-scratch disease 10.4 CRP CD4
48 parotid disease 10.4 CRP CD4
49 mikulicz disease 10.4 CRP CD4
50 abdominal tuberculosis 10.4 CRP CD4

Graphical network of the top 20 diseases related to Pyomyositis:



Diseases related to Pyomyositis

Symptoms & Phenotypes for Pyomyositis

Human phenotypes related to Pyomyositis:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
3 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
4 myositis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100614
5 recurrent cutaneous abscess formation 58 31 hallmark (90%) Very frequent (99-80%) HP:0100838
6 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
7 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
8 testicular teratoma 58 31 frequent (33%) Frequent (79-30%) HP:0100616
9 sudden cardiac death 58 31 occasional (7.5%) Occasional (29-5%) HP:0001645
10 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
11 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
12 recurrent infections 58 Frequent (79-30%)

Drugs & Therapeutics for Pyomyositis

Drugs for Pyomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cephalexin Approved, Investigational, Vet_approved Phase 1 15686-71-2 27447
2 Anti-Bacterial Agents Phase 1
3 Anti-Infective Agents Phase 1
4
Mupirocin Approved, Investigational, Vet_approved 12650-69-0 446596
5 Chlorhexidine gluconate
6 methicillin
7 Dermatologic Agents
8 Anti-Infective Agents, Local
9 Sodium hypochlorite
10 Disinfectants
11 Eusol

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
2 The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and an Evaluation of Decolonization Strategies Completed NCT00513799 Mupirocin ointment
3 Plasma-Based Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections Not yet recruiting NCT03846804

Search NIH Clinical Center for Pyomyositis

Cochrane evidence based reviews: pyomyositis

Genetic Tests for Pyomyositis

Anatomical Context for Pyomyositis

MalaCards organs/tissues related to Pyomyositis:

40
Bone, Skeletal Muscle, Skin, Kidney, Myeloid, Breast, Liver

Publications for Pyomyositis

Articles related to Pyomyositis:

(show top 50) (show all 1076)
# Title Authors PMID Year
1
[Inflammatory myopathy following acute meningoccemia in a properdin-deficient patient: A case report]. 61
31735371 2020
2
[Pyomyositis due to Streptococcus pyogenes in a patient with venolymphatic malformation. Report of one pediatric case]. 61
31758910 2019
3
Diagnostic accuracy of 16S rDNA PCR in bacterial pyomyositis: A prospective study. 61
31430482 2019
4
Pyomyositis secondary to prostatic abscesses. 61
30361055 2019
5
Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children. 61
31567961 2019
6
An unusual clinical presentation of tuberculous pyomyositis in a renal allograft recipient. 61
31696860 2019
7
Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections. 61
31482119 2019
8
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. 61
31029399 2019
9
Extensive pyomyositis of prevertebral muscles after acupuncture: Case report. 61
31321345 2019
10
Piriformis pyomyositis, a cause of piriformis syndrome-a systematic search and review. 61
31049761 2019
11
Correction to: Piriformis pyomyositis, a cause of piriformis syndrome-a systematic search and review. 61
31134505 2019
12
Dalbavancin treatment of methicillin-susceptible Staphylococcus aureus pyomyositis with torpid evolution: a case report. 61
31037932 2019
13
Case report: Anaerobiospirillum prosthetic joint infection in a heart transplant recipient. 61
31238924 2019
14
[Pediatric pyomyositis: Experience in a Pediatric Reference Center in Argentina]. 61
31859757 2019
15
Multiple pyomyositis secondary to septic thrombophlebitis. 61
30340839 2019
16
Diagnosis and Management of Infectious Arthritis in Children. 61
31144135 2019
17
Adherence to antibiotic guidelines for erysipelas or cellulitis is associated with a favorable outcome. 61
30685804 2019
18
Piriformis Pyomyositis in a Patient with Kikuchi-Fujimoto Disease - A Case Report and Literature Review. 61
31363271 2019
19
Multifocal Οsteomyelitis Localization after Pyomyositis in Children: Importance of Timely Response. 61
31249741 2019
20
Pyomyositis of the Vastus Medialis: A Case Report. 61
30969236 2019
21
[Streptococcus pyogenes pyomyositis of the piriformis muscle in a child]. 61
30869499 2019
22
Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS. 61
30794157 2019
23
Pyomyositis in a Patient with IgA Nephropathy and Kidney Transplant. 61
30911428 2019
24
The Limping Child, a Rare Differential: Pyomyositis of the Iliacus Muscle -A Case Report. 61
31534927 2019
25
Primary Pyomyositis: Contact Sports as the Rare Risk Factors. 61
31467743 2019
26
Point-of-Care Ultrasound to Diagnose Pyomyositis in a Child. 61
30608330 2019
27
Uncommon primary Group A streptococcal erector spinae pyomyositis diagnosed as muscle strain in a fit young male. 61
30967957 2019
28
Percutaneous transgluteal computed tomography-guided aspiration of obturator internus pyomyositis in adolescent athlete: A case report and literature review. 61
30233741 2018
29
Fever and Hip Pain: Not Always Due to a Septic Hip. 61
28257312 2018
30
Pyomyositis Diagnosed by Point-of-Care Ultrasound in the Emergency Department. 61
30274728 2018
31
Cellulitis and posterior cervical pyomyositis by methicillin-resistant Staphylococcus aureus in a diabetic patient. 61
29295786 2018
32
An Unusual Presentation of Pectoralis Major Pyomyositis Presenting as Septic Arthritis of the Shoulder: A Case Report and Review of the Literature. 61
30423796 2018
33
Disseminated Pyomyositis Due to Burkholderia cepacia: A Case Report. 61
30598571 2018
34
Postinfectious heterotopic ossification of the ilium involving the iliacus muscle. 61
28704300 2018
35
Pyomyositis: an unusual cause of hip pain in a patient on certolizumab pegol and leflunomide. 61
29660056 2018
36
Case of acute paraspinal pyomyositis in an elderly diabetic secondary to spread from urinary tract infection. 61
30139787 2018
37
A prospective study of screening for musculoskeletal pathology in the child with a limp or pseudoparalysis using erythrocyte sedimentation rate, C-reactive protein and MRI. 61
30154932 2018
38
Severe Rhabdomyolysis as an Unusual Presentation of Primary Human Immunodeficiency Virus Infection. 61
30258740 2018
39
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). 61
29905925 2018
40
Serious life-threatening multifocal infection in a child, caused by Panton-Valentine leucocidin-producing Staphylococcus aureus (PVL-MSSA). 61
29871957 2018
41
Pelvic pyomyositis in children: changing trends in occurrence and management. 61
29289987 2018
42
Primary pyomyositis in children. 61
29274860 2018
43
A Novel Classification System Based on Dissemination of Musculoskeletal Infection is Predictive of Hospital Outcomes. 61
27299780 2018
44
Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. 61
28877155 2018
45
Point-of-care ultrasound in pyomyositis: A case series. 61
29046245 2018
46
Gram-Negative Pyomyositis in an Immunocompetent Patient. 61
29888157 2018
47
Primary pyomyositis in North India: a clinical, microbiological, and outcome study. 61
29338140 2018
48
Abdominal rectus muscle pyomyositis: Report of a case and review of the literature. 61
29721242 2018
49
Subscapularis pyomyositis: a rare presentation of shoulder pain. 61
29549135 2018
50
Metastatic MSSA infection of the spine and extremities. 61
29507017 2018

Variations for Pyomyositis

Expression for Pyomyositis

Search GEO for disease gene expression data for Pyomyositis.

Pathways for Pyomyositis

Pathways related to Pyomyositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.09 CSF3 CD4

GO Terms for Pyomyositis

Sources for Pyomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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