PM
MCID: PYM001
MIFTS: 46

Pyomyositis (PM)

Categories: Bone diseases, Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Pyomyositis

MalaCards integrated aliases for Pyomyositis:

Name: Pyomyositis 12 77 54 60 45 15 17 74
Tropical Pyomyositis 12 60 74
Myositis Purulenta Tropica 60
Suppurative Myositis 60
Myositis Tropicans 60
Purulent Myositis 74
Pm 60

Characteristics:

Orphanet epidemiological data:

60
pyomyositis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:876
ICD9CM 36 040.81
MeSH 45 D052880
NCIt 51 C128382
SNOMED-CT 69 65110003
ICD10 34 M60.0
MESH via Orphanet 46 D052880
ICD10 via Orphanet 35 M60.0
UMLS via Orphanet 75 C0041188 C1704275
Orphanet 60 ORPHA764

Summaries for Pyomyositis

NIH Rare Diseases : 54 Pyomyositis is rare bacterial infection of the skeletal muscle (the muscles used for movement). Signs and symptoms may include pain and tenderness of the affected muscle, fever, and abscess formation. If left untreated, the abscess may extend into the bone and joint or blood poisoning may occur. Approximately 90% of cases are caused by the bacterium, Staphylococcus aureus. Risk factors for the condition include strenuous activity, muscle trauma, skin infections, infected insect bites, illicit drug injections, connective tissue disorders, and diabetes. Treatment generally includes surgical drainage of the abscess and antibiotics.

MalaCards based summary : Pyomyositis, also known as tropical pyomyositis, is related to myeloma, multiple and arthritis. An important gene associated with Pyomyositis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Development NOTCH1-mediated pathway for NF-KB activity modulation. The drugs Isoniazid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, bone and skin, and related phenotypes are fever and subcutaneous nodule

Wikipedia : 77 Pyomyositis, also known as tropical pyomyositis or myositis tropicans, is a bacterial infection of the... more...

Related Diseases for Pyomyositis

Diseases related to Pyomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 29.6 CRP MYOM2
2 arthritis 10.5
3 osteomyelitis 10.4
4 septic arthritis 10.3
5 leukemia 10.3
6 diabetes mellitus 10.2
7 epidural abscess 10.2
8 acquired immunodeficiency syndrome 10.2
9 myositis 10.1
10 rheumatoid arthritis 10.1
11 compartment syndrome 10.1
12 systemic lupus erythematosus 10.1
13 lymphocytic leukemia 10.1
14 lemierre's syndrome 10.1
15 toxic shock syndrome 10.1
16 lupus erythematosus 10.1
17 mononeuritis multiplex 10.0 CRP MYOM2
18 aplastic anemia 10.0
19 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
20 endocarditis 10.0
21 fasciitis 10.0
22 necrotizing fasciitis 10.0
23 streptococcal meningitis 10.0 CRP MYOM2
24 heart valve disease 10.0 CRP MYOM2
25 breast cancer 10.0
26 acute lymphocytic leukemia 10.0
27 hepatitis 10.0
28 neutropenia 10.0
29 thrombosis 10.0
30 cellulitis 10.0
31 human immunodeficiency virus infectious disease 10.0
32 pneumonia 10.0
33 myeloid leukemia 10.0
34 meningitis 10.0
35 bacterial myositis 10.0
36 subclavian steal syndrome 9.9 CRP NOTCH1
37 thrombophilia due to thrombin defect 9.9
38 endometrial cancer 9.9
39 diabetes mellitus, ketosis-prone 9.9
40 leukemia, acute lymphoblastic 9.9
41 chronic granulomatous disease 9.9
42 dermatomyositis 9.9
43 sarcoma 9.9
44 myopathy 9.9
45 influenza 9.9
46 ritter's disease 9.9
47 toxocariasis 9.9
48 acute respiratory distress syndrome 9.9
49 haemophilus influenzae 9.9
50 piriformis syndrome 9.9

Graphical network of the top 20 diseases related to Pyomyositis:



Diseases related to Pyomyositis

Symptoms & Phenotypes for Pyomyositis

Human phenotypes related to Pyomyositis:

60 33 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
3 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
4 recurrent cutaneous abscess formation 60 33 hallmark (90%) Very frequent (99-80%) HP:0100838
5 myositis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100614
6 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
7 leukocytosis 60 33 frequent (33%) Frequent (79-30%) HP:0001974
8 testicular teratoma 60 33 frequent (33%) Frequent (79-30%) HP:0100616
9 sudden cardiac death 60 33 occasional (7.5%) Occasional (29-5%) HP:0001645
10 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
11 sepsis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100806
12 recurrent infections 60 Frequent (79-30%)

GenomeRNAi Phenotypes related to Pyomyositis according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 CRP NONO NOTCH1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.66 NONO NOTCH1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 CRP NOTCH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 NONO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 CRP NOTCH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.66 NONO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 NONO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.66 NOTCH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.66 NONO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 NOTCH1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 NONO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.66 CRP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.66 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 CRP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.66 NOTCH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.66 NOTCH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.66 NONO

Drugs & Therapeutics for Pyomyositis

Drugs for Pyomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2 Anti-Bacterial Agents Phase 3,Phase 1
3 Antiviral Agents Phase 3
4 Antimetabolites Phase 3
5 Anti-Infective Agents Phase 3,Phase 1
6 Hypolipidemic Agents Phase 3
7 Antitubercular Agents Phase 3
8 Anti-Retroviral Agents Phase 3
9 Lipid Regulating Agents Phase 3
10
Cephalexin Approved, Investigational, Vet_approved Phase 1 15686-71-2 27447

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
2 Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections Not yet recruiting NCT03802552 Phase 1 Cefadroxil;Cephalexin
3 Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections Not yet recruiting NCT03846804

Search NIH Clinical Center for Pyomyositis

Cochrane evidence based reviews: pyomyositis

Genetic Tests for Pyomyositis

Anatomical Context for Pyomyositis

MalaCards organs/tissues related to Pyomyositis:

42
Skeletal Muscle, Bone, Skin, Breast, Bone Marrow, Myeloid, Brain

Publications for Pyomyositis

Articles related to Pyomyositis:

(show top 50) (show all 676)
# Title Authors Year
1
Point-of-Care Ultrasound to Diagnose Pyomyositis in a Child. ( 30608330 )
2019
2
Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS. ( 30794157 )
2019
3
Pyomyositis in a Patient with IgA Nephropathy and Kidney Transplant. ( 30911428 )
2019
4
Pyomyositis and osteomyelitis: an unusual cause of abdominal pain. ( 29559487 )
2018
5
Pyomyositis: an unusual cause of hip pain in a patient on certolizumab pegol and leflunomide. ( 29660056 )
2018
6
Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )
2018
7
Pyomyositis presenting as septic arthritis. ( 29559212 )
2018
8
Pyomyositis in the setting of complicated diverticulitis: case report. ( 29317845 )
2018
9
Group A Streptococcal Pyomyositis in a Previously Healthy Six-year-old Girl. ( 29644156 )
2018
10
Gram-Negative Pyomyositis in an Immunocompetent Patient. ( 29888157 )
2018
11
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
12
Subscapularis pyomyositis: a rare presentation of shoulder pain. ( 29549135 )
2018
13
Combined Labeled Leukocyte and Technicium 99 Sulfur Colloid Bone Marrow Imaging: Differentiating Primary Pyomyositis Pseudotumor from Osteomyelitis and Multiple Bone Infarcts. ( 29772988 )
2018
14
<i>Candida albicans</i> Pyomyositis in a Patient with Systemic Lupus Erythematosus. ( 29419450 )
2018
15
Abdominal rectus muscle pyomyositis: Report of a case and review of the literature. ( 29721242 )
2018
16
Primary pyomyositis in North India: a clinical, microbiological, and outcome study. ( 29338140 )
2018
17
Concurrent methicillin-resistant Staphylococcus aureus septicemia and pyomyositis in a patient with dengue hemorrhagic fever: a case report. ( 29486726 )
2018
18
Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis. ( 29657883 )
2018
19
An Unusual Presentation of Pectoralis Major Pyomyositis Presenting as Septic Arthritis of the Shoulder: A Case Report and Review of the Literature. ( 30423796 )
2018
20
Case of acute paraspinal pyomyositis in an elderly diabetic secondary to spread from urinary tract infection. ( 30139787 )
2018
21
Percutaneous transgluteal computed tomography-guided aspiration of obturator internus pyomyositis in adolescent athlete: A case report and literature review. ( 30233741 )
2018
22
Pyomyositis Diagnosed by Point-of-Care Ultrasound in the Emergency Department. ( 30274728 )
2018
23
Multiple pyomyositis secondary to septic thrombophlebitis. ( 30340839 )
2018
24
Pyomyositis secondary to prostatic abscesses. ( 30361055 )
2018
25
Failed Early Intervention of Pyomyositis in an Immunocompetent Individual. ( 30595930 )
2018
26
Disseminated Pyomyositis Due to Burkholderia cepacia: A Case Report. ( 30598571 )
2018
27
Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report. ( 29179775 )
2017
28
Pelvic pyomyositis in children: changing trends in occurrence and management. ( 29289987 )
2017
29
Bilateral Neck Pyomyositis Caused by<i>Staphylococcus capitis</i>and<i>Staphylococcus saccharolyticus</i>in a Diabetic Adult. ( 29109878 )
2017
30
Peculiar purulence: Hypervirulent Klebsiella pneumoniae causing pyomyositis. ( 29030138 )
2017
31
Tropical Pyomyositis: Revisited. ( 28331264 )
2017
32
Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. ( 28877155 )
2017
33
Pyomyositis of the pectineus muscle in an adolescent male. ( 28853599 )
2017
34
Point-of-care ultrasound in pyomyositis: A case series. ( 29046245 )
2017
35
Pyomyositis in a Patient with AIDS. ( 28626195 )
2017
36
Pyomyositis of Gluteus medius: A case report and review of the literature. ( 29181353 )
2017
37
Nocardial pyomyositis. ( 28298844 )
2017
38
Pyomyositis Complicated by Deep Venous Thrombosis - A Unique Case of Reverse Lemierre's Syndrome. ( 28462553 )
2017
39
Extraintestinal Salmonellosis in the Immunocompromised: An Unusual Case of Pyomyositis. ( 29081808 )
2017
40
Breakthrough fusariosis presenting initially with pyomyositis. ( 27914686 )
2017
41
<i>Streptococcus dysagalactiae</i> pyomyositis. ( 29264084 )
2017
42
Cellulitis and posterior cervical pyomyositis by Staphylococcus aureus methicillin resistant in diabetic patient. ( 29295786 )
2017
43
Haemophilus influenzae Pyomyositis in a Patient with Diabetic Ketoacidosis: A Unique Case and Review of Literature. ( 28352482 )
2017
44
Thigh pyomyositis caused by group A streptococcus in an immunocompetent adult without any cause. ( 28063458 )
2017
45
Panton-Valentine Leukocidin Producing Staphylococcus aureus Facial Pyomyositis Causing Partial Cavernous Sinus Thrombosis. ( 28640000 )
2017
46
The Brief Case: Anaerobiospirillum succiniciproducens Bacteremia and Pyomyositis. ( 28232502 )
2017
47
Primary pyomyositis in children. ( 29274860 )
2017
48
Salmonella pyomyositis with concurrent sacroiliac osteomyelitis presenting as piriformis syndrome: A rare case. ( 27779154 )
2017
49
Multifocal pyomyositis after intra-articular injections. ( 29264046 )
2017
50
Team Approach: Pyomyositis. ( 28654470 )
2017

Variations for Pyomyositis

Expression for Pyomyositis

Search GEO for disease gene expression data for Pyomyositis.

Pathways for Pyomyositis

Pathways related to Pyomyositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.85 NONO NOTCH1

GO Terms for Pyomyositis

Biological processes related to Pyomyositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac muscle tissue morphogenesis GO:0055008 8.62 MYOM2 NOTCH1

Sources for Pyomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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