MCID: PYR016
MIFTS: 36

Pyridoxine Deficiency

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Pyridoxine Deficiency

MalaCards integrated aliases for Pyridoxine Deficiency:

Name: Pyridoxine Deficiency 53 55 73
Vitamin B6 Deficiency 53 55
Vitamin Deficiency, B6 53
Vitamin B 6 Deficiency 73

Classifications:



External Ids:

ICD10 33 E53.1
UMLS 73 C1527330

Summaries for Pyridoxine Deficiency

MalaCards based summary : Pyridoxine Deficiency, also known as vitamin b6 deficiency, is related to hepatitis and liver disease. An important gene associated with Pyridoxine Deficiency is CBS (Cystathionine-Beta-Synthase), and among its related pathways/superpathways are One carbon pool by folate and Folate Metabolism. The drugs Methionine and Pyridoxine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological... more...

Related Diseases for Pyridoxine Deficiency

Diseases related to Pyridoxine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 hepatitis 28.4 GPT SLC17A5
2 liver disease 28.2 GPT SLC17A5
3 pyridoxine deficiency anemia 12.2
4 tinea unguium 10.1 CBS GPT
5 neuropathy 10.0
6 porphyria 9.9
7 audiogenic seizures 9.8
8 status epilepticus 9.8
9 peripheral nervous system disease 9.8
10 deficiency anemia 9.8
11 paraquat poisoning 9.8 GPT SLC17A5
12 kwashiorkor 9.7 GPT SLC17A5
13 nonalcoholic steatohepatitis 9.7 GPT SLC17A5
14 fascioliasis 9.7 GPT SLC17A5
15 choledocholithiasis 9.7 GPT SLC17A5
16 scrub typhus 9.7 GPT SLC17A5
17 analbuminemia 9.7 GPT SLC17A5
18 leukemia 9.7
19 seborrheic dermatitis 9.7
20 carcinoid syndrome 9.7
21 sarcoma 9.7
22 depression 9.7
23 arteriosclerosis 9.7
24 dermatitis 9.7
25 acute porphyria 9.7
26 porphyria, acute intermittent 9.7
27 bronchus adenoma 9.7
28 celiac disease 1 9.7
29 cystathioninuria 9.7
30 adenoma 9.7
31 hyperthyroidism 9.7
32 cataract 9.7
33 neuronitis 9.7
34 congestive heart failure 9.7
35 periodontitis 9.7
36 diabetic neuropathy 9.7
37 acute liver failure 9.7 GPT SLC17A5
38 bilirubin metabolic disorder 9.7 GPT SLC17A5
39 obstructive jaundice 9.6 GPT SLC17A5
40 hepatic encephalopathy 9.6 GPT SLC17A5
41 alcoholic hepatitis 9.6 GPT SLC17A5
42 alcohol abuse 9.6 GPT SLC17A5
43 viral hepatitis 9.6 GPT SLC17A5
44 hellp syndrome 9.5 GPT SLC17A5
45 fatty liver disease 9.5 GPT SLC17A5
46 liver cirrhosis 9.4 GPT SLC17A5
47 hepatitis b 9.3 GPT SLC17A5

Graphical network of the top 20 diseases related to Pyridoxine Deficiency:



Diseases related to Pyridoxine Deficiency

Symptoms & Phenotypes for Pyridoxine Deficiency

GenomeRNAi Phenotypes related to Pyridoxine Deficiency according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 SLC17A5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.47 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 SLC17A5
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.47 SLC17A5 GSR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.47 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.47 GSR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.47 GSR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.47 SLC17A5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.47 GSR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.47 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.47 SLC17A5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.47 GSR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.47 GSR

Drugs & Therapeutics for Pyridoxine Deficiency

Drugs for Pyridoxine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methionine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 63-68-3 6137
2
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 65-23-6 1054
3
Serine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 56-45-1 5951
4
Pyridoxal Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 66-72-8 1050
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Not Applicable 59-30-3 6037
6 Micronutrients Phase 2, Phase 3,Not Applicable
7 Contraceptive Agents Phase 2, Phase 3
8 Contraceptives, Oral Phase 2, Phase 3
9 Contraceptives, Oral, Combined Phase 2, Phase 3
10 Trace Elements Phase 2, Phase 3,Not Applicable
11 Vitamin B 6 Phase 2, Phase 3,Not Applicable
12 Vitamin B Complex Phase 2, Phase 3,Not Applicable
13 Vitamins Phase 2, Phase 3,Not Applicable
14 Folate Nutraceutical Phase 2, Phase 3,Not Applicable
15 leucine Nutraceutical Phase 2, Phase 3,Not Applicable
16 Vitamin B9 Nutraceutical Phase 2, Phase 3,Not Applicable
17
Glycine Approved, Nutraceutical, Vet_approved Not Applicable 56-40-6 750
18 Neurotransmitter Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects for Women Taking Birth Control Pills Completed NCT01128244 Phase 2, Phase 3
2 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812 Not Applicable
3 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275
4 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Pyridoxine Deficiency

Genetic Tests for Pyridoxine Deficiency

Anatomical Context for Pyridoxine Deficiency

MalaCards organs/tissues related to Pyridoxine Deficiency:

41
Liver, Brain, Kidney, Myeloid, Testes, Adrenal Cortex, Pituitary

Publications for Pyridoxine Deficiency

Articles related to Pyridoxine Deficiency:

(show top 50) (show all 227)
# Title Authors Year
1
Vitamin, B6 (Pyridoxine), Deficiency ( 29261855 )
2017
2
Dietary pyridoxine deficiency reduced growth performance and impaired intestinal immune function associated with TOR and NF-I_B signalling of young grass carp (Ctenopharyngodon idella). ( 28951222 )
2017
3
Pyridoxine Deficiency After Solid Organ Transplant. ( 29187089 )
2017
4
Pyridoxine deficiency in adult patients with status epilepticus. ( 26418265 )
2015
5
Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. ( 25137514 )
2014
6
The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. ( 19637937 )
2009
7
Effect of pyridoxine deficiency on the structural and functional development of hippocampus. ( 15648402 )
2004
8
Confusion associated with isoniazid-induced pyridoxine deficiency. ( 15546832 )
2004
9
Electrocardiographic changes due to pyridoxine deficiency. ( 12765460 )
2003
10
Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men. ( 9625217 )
1998
11
Pyridoxine deficiency: new approaches in immunosuppression and chemotherapy. ( 9497969 )
1997
12
Pyridoxine deficiency affects biomechanical properties of chick tibial bone. ( 8805998 )
1996
13
Are neuropsychiatric manifestations of folate, cobalamin and pyridoxine deficiency mediated through imbalances in excitatory sulfur amino acids? ( 7838008 )
1994
14
Effects of pyridoxine deficiency on the metabolism of N-nitrosodimethylamine in the rat. ( 7931719 )
1994
15
Effect of pyridoxine deficiency on maturation of neuromotor coordinations. ( 8063354 )
1994
16
Tubuloreticular structures in pyridoxine deficiency. ( 8385515 )
1993
17
Thiamine, riboflavin, and pyridoxine deficiencies in a population of critically ill children. ( 1403385 )
1992
18
Effect of pyridoxine deficiency on immunological phenomena. ( 1409221 )
1992
19
Behavioral consequences of pyridoxine deficiency in mothers and infants. ( 1749530 )
1991
20
Increased calcium influx in caudal artery of rats made hypertensive with pyridoxine deficiency. ( 1645979 )
1991
21
Effect of riboflavin or pyridoxine deficiency on inflammatory response. ( 1812086 )
1991
22
Effect of pyridoxine-deficiency on degradation of cytosolic aspartate aminotransferase in rat liver lysosomes. ( 1765846 )
1991
23
Effect of pyridoxine deficiency on the adrenal cortex. ( 1797578 )
1991
24
Oxalate binding to rat intestinal brush-border membrane in pyridoxine deficiency: a kinetic study. ( 2036434 )
1991
25
Pyridoxine deficiency and antagonism produce increased ground substance viscosity with resulting seborrheic dermatitis and increased tumor resistance. ( 2533316 )
1989
26
Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney. ( 3183775 )
1988
27
Neuroendocrinology of pyridoxine deficiency. ( 3067155 )
1988
28
Effect of pyridoxine deficiency in the neuronally mature rat. ( 3654110 )
1987
29
Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus. ( 3586647 )
1987
30
Pyridoxine deficiency and ethanol-induced liver injury. ( 3307510 )
1987
31
Pyridoxine deficiency and phospholipid metabolism. ( 3796900 )
1986
32
Effect of pyridoxine-deficiency on the turnover of aspartate aminotransferase isozymes in rat liver. ( 3711050 )
1986
33
The lack of effect of a pyridoxine deficiency on the utilization of the hydroxyl analogue of methionine by the chick. ( 3737508 )
1986
34
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes. ( 3736351 )
1986
35
Effect of pyridoxine deficiency on ornithine aminotransferase in rat kidney and liver. ( 3834046 )
1985
36
Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain. ( 3875501 )
1985
37
Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups. ( 2864042 )
1985
38
Pyridoxine deficiency in children treated with isoniazid. ( 3987378 )
1985
39
Effect of pyridoxine deficiency in young rats on high-affinity serotonin and dopamine receptors. ( 4046074 )
1985
40
The effect of pyridoxine deficiency on the metabolism of the aromatic amino acids by isolated rat liver cells. ( 4026305 )
1985
41
Effect of pyridoxine deficiency on the exploratory behavior of rats. ( 6542091 )
1984
42
Phenelzine-induced pyridoxine deficiency. ( 6470198 )
1984
43
Effect of pyridoxine deficiency on intestinal absorption of calcium and oxalate: chemical composition of brush border membranes in rats. ( 6497870 )
1984
44
Pyridoxine deficiency with phenelzine. ( 6719168 )
1984
45
Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy. ( 6638055 )
1983
46
Glucose tolerance in subclinical pyridoxine deficiency in man. ( 6351588 )
1983
47
Pyridoxine deficiency. ( 7073427 )
1982
48
Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients. ( 7139210 )
1982
49
Effect of pyridoxine-deficiency on the syntheses of aspartate aminotransferase in rat liver and muscle in vivo. ( 7174638 )
1982
50
Powdered goat's milk: pyridoxine deficiency and status epilepticus. ( 7083720 )
1982

Variations for Pyridoxine Deficiency

Expression for Pyridoxine Deficiency

Search GEO for disease gene expression data for Pyridoxine Deficiency.

Pathways for Pyridoxine Deficiency

GO Terms for Pyridoxine Deficiency

Biological processes related to Pyridoxine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.96 CBS GPT
2 L-serine metabolic process GO:0006563 8.62 CBS SHMT2

Molecular functions related to Pyridoxine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.8 CBS GPT SHMT2

Sources for Pyridoxine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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