MCID: PYR016
MIFTS: 33

Pyridoxine Deficiency

Categories: Metabolic diseases, Rare diseases

Aliases & Classifications for Pyridoxine Deficiency

MalaCards integrated aliases for Pyridoxine Deficiency:

Name: Pyridoxine Deficiency 54 56 74
Vitamin Deficiency, B6 54
Vitamin B 6 Deficiency 74
Vitamin B6 Deficiency 54

Classifications:



External Ids:

ICD10 34 E53.1

Summaries for Pyridoxine Deficiency

MalaCards based summary : Pyridoxine Deficiency, also known as vitamin deficiency, b6, is related to pyridoxine deficiency anemia and pyridoxamine 5-prime-phosphate oxidase deficiency. An important gene associated with Pyridoxine Deficiency is GSR (Glutathione-Disulfide Reductase), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Folic Acid and Pyridoxine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney.

Wikipedia : 77 Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological... more...

Related Diseases for Pyridoxine Deficiency

Diseases related to Pyridoxine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 pyridoxine deficiency anemia 12.4
2 pyridoxamine 5-prime-phosphate oxidase deficiency 11.3
3 homocysteinemia 10.2
4 neuropathy 10.2
5 uremia 10.1
6 porphyria 10.1
7 deficiency anemia 10.0
8 leukemia 10.0
9 liver disease 10.0
10 status epilepticus 10.0
11 arteriosclerosis 10.0
12 peripheral nervous system disease 10.0
13 lymphosarcoma 10.0
14 audiogenic seizures 10.0
15 bladder cancer 9.9
16 carpal tunnel syndrome 9.9
17 rheumatoid arthritis 9.9
18 hyperprolinemia, type ii 9.9
19 asplenia, isolated congenital 9.9
20 aging 9.9
21 sickle cell anemia 9.9
22 mononeuropathy of the median nerve, mild 9.9
23 alcohol abuse 9.9
24 arthritis 9.9
25 common variable immunodeficiency 9.9
26 crohn's disease 9.9
27 lymphoid leukemia 9.9
28 atrial fibrillation 9.9
29 omphalocele 9.9
30 nephrotic syndrome 9.9
31 nephrocalcinosis 9.9
32 kwashiorkor 9.9
33 urogenital tuberculosis 9.9
34 dental caries 9.9
35 macrocytic anemia 9.9
36 angular blepharoconjunctivitis 9.9
37 blepharoconjunctivitis 9.9
38 axonal neuropathy 9.9
39 pellagra 9.9
40 sideroblastic anemia 9.9
41 meningitis 9.9
42 hyperprolinemia 9.9
43 papillomatosis, confluent and reticulated 9.8
44 porphyria, acute intermittent 9.8
45 celiac disease 1 9.8
46 cystathioninuria 9.8
47 acute leukemia 9.8
48 cataract 9.8
49 congestive heart failure 9.8
50 diabetic neuropathy 9.8

Graphical network of the top 20 diseases related to Pyridoxine Deficiency:



Diseases related to Pyridoxine Deficiency

Symptoms & Phenotypes for Pyridoxine Deficiency

Drugs & Therapeutics for Pyridoxine Deficiency

Drugs for Pyridoxine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Not Applicable 59-30-3 6037
2
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 65-23-6 1054
3
Methionine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 63-68-3 6137
4
Serine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 56-45-1 5951
5 Vitamin B 6 Phase 2, Phase 3,Not Applicable
6 Vitamin B Complex Phase 2, Phase 3,Not Applicable
7 Vitamins Phase 2, Phase 3,Not Applicable
8 Trace Elements Phase 2, Phase 3,Not Applicable
9 Contraceptive Agents Phase 2, Phase 3
10 Vitamin B9 Phase 2, Phase 3,Not Applicable
11 Micronutrients Phase 2, Phase 3,Not Applicable
12 leucine Phase 2, Phase 3,Not Applicable
13 Folate Phase 2, Phase 3,Not Applicable
14 Contraceptives, Oral, Combined Phase 2, Phase 3
15 Contraceptives, Oral Phase 2, Phase 3
16 Nutrients Phase 2, Phase 3,Not Applicable
17
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3,Not Applicable 66-72-8 1050
18
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
19
leucovorin Approved Not Applicable 58-05-9 143 6006
20
Glycine Approved, Nutraceutical, Vet_approved Not Applicable 56-40-6 750
21
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
22
Cobalamin Experimental Not Applicable 13408-78-1 6857388
23 Neurotransmitter Agents Not Applicable
24 Vitamin B12 Not Applicable
25 Vitamin B 12 Not Applicable
26 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects for Women Taking Birth Control Pills Completed NCT01128244 Phase 2, Phase 3
2 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812 Not Applicable
3 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275
4 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Pyridoxine Deficiency

Genetic Tests for Pyridoxine Deficiency

Anatomical Context for Pyridoxine Deficiency

MalaCards organs/tissues related to Pyridoxine Deficiency:

42
Brain, Heart, Kidney, Skin, Cortex, Bone, Liver

Publications for Pyridoxine Deficiency

Articles related to Pyridoxine Deficiency:

(show top 50) (show all 230)
# Title Authors Year
1
Dietary pyridoxine deficiency reduced growth performance and impaired intestinal immune function associated with TOR and NF-κB signalling of young grass carp (Ctenopharyngodon idella). ( 28951222 )
2017
2
Pyridoxine Deficiency After Solid Organ Transplant. ( 29187089 )
2017
3
Pyridoxine deficiency in adult patients with status epilepticus. ( 26418265 )
2015
4
Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. ( 25137514 )
2014
5
The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. ( 19637937 )
2009
6
Confusion associated with isoniazid-induced pyridoxine deficiency. ( 15546832 )
2004
7
Effect of pyridoxine deficiency on the structural and functional development of hippocampus. ( 15648402 )
2004
8
Electrocardiographic changes due to pyridoxine deficiency. ( 12765460 )
2003
9
Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men. ( 9625217 )
1998
10
Pyridoxine deficiency: new approaches in immunosuppression and chemotherapy. ( 9497969 )
1997
11
Pyridoxine deficiency affects biomechanical properties of chick tibial bone. ( 8805998 )
1996
12
Are neuropsychiatric manifestations of folate, cobalamin and pyridoxine deficiency mediated through imbalances in excitatory sulfur amino acids? ( 7838008 )
1994
13
Effects of pyridoxine deficiency on the metabolism of N-nitrosodimethylamine in the rat. ( 7931719 )
1994
14
Effect of pyridoxine deficiency on maturation of neuromotor coordinations. ( 8063354 )
1994
15
Tubuloreticular structures in pyridoxine deficiency. ( 8385515 )
1993
16
Effect of pyridoxine deficiency on immunological phenomena. ( 1409221 )
1992
17
Increased calcium influx in caudal artery of rats made hypertensive with pyridoxine deficiency. ( 1645979 )
1991
18
Behavioral consequences of pyridoxine deficiency in mothers and infants. ( 1749530 )
1991
19
Effect of pyridoxine-deficiency on degradation of cytosolic aspartate aminotransferase in rat liver lysosomes. ( 1765846 )
1991
20
Effect of pyridoxine deficiency on the adrenal cortex. ( 1797578 )
1991
21
Effect of riboflavin or pyridoxine deficiency on inflammatory response. ( 1812086 )
1991
22
Oxalate binding to rat intestinal brush-border membrane in pyridoxine deficiency: a kinetic study. ( 2036434 )
1991
23
Pyridoxine deficiency and antagonism produce increased ground substance viscosity with resulting seborrheic dermatitis and increased tumor resistance. ( 2533316 )
1989
24
Neuroendocrinology of pyridoxine deficiency. ( 3067155 )
1988
25
Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney. ( 3183775 )
1988
26
Pyridoxine deficiency and ethanol-induced liver injury. ( 3307510 )
1987
27
Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus. ( 3586647 )
1987
28
Effect of pyridoxine deficiency in the neuronally mature rat. ( 3654110 )
1987
29
Effect of pyridoxine-deficiency on the turnover of aspartate aminotransferase isozymes in rat liver. ( 3711050 )
1986
30
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes. ( 3736351 )
1986
31
The lack of effect of a pyridoxine deficiency on the utilization of the hydroxyl analogue of methionine by the chick. ( 3737508 )
1986
32
Pyridoxine deficiency and phospholipid metabolism. ( 3796900 )
1986
33
Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups. ( 2864042 )
1985
34
Effect of pyridoxine deficiency on ornithine aminotransferase in rat kidney and liver. ( 3834046 )
1985
35
Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain. ( 3875501 )
1985
36
Pyridoxine deficiency in children treated with isoniazid. ( 3987378 )
1985
37
The effect of pyridoxine deficiency on the metabolism of the aromatic amino acids by isolated rat liver cells. ( 4026305 )
1985
38
Effect of pyridoxine deficiency in young rats on high-affinity serotonin and dopamine receptors. ( 4046074 )
1985
39
Phenelzine-induced pyridoxine deficiency. ( 6470198 )
1984
40
Effect of pyridoxine deficiency on intestinal absorption of calcium and oxalate: chemical composition of brush border membranes in rats. ( 6497870 )
1984
41
Effect of pyridoxine deficiency on the exploratory behavior of rats. ( 6542091 )
1984
42
Pyridoxine deficiency with phenelzine. ( 6719168 )
1984
43
Glucose tolerance in subclinical pyridoxine deficiency in man. ( 6351588 )
1983
44
Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy. ( 6638055 )
1983
45
Pyridoxine deficiency. ( 7073427 )
1982
46
Powdered goat's milk: pyridoxine deficiency and status epilepticus. ( 7083720 )
1982
47
Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients. ( 7139210 )
1982
48
Effect of pyridoxine deficiency on activities and amounts of aspartate aminotransferase isozymes in rat tissues. ( 7153207 )
1982
49
Effect of pyridoxine-deficiency on the syntheses of aspartate aminotransferase in rat liver and muscle in vivo. ( 7174638 )
1982
50
Alterations of phospholipid and triglyceride metabolism in fatty liver caused by pyridoxine deficiency in rats. ( 7175577 )
1982

Variations for Pyridoxine Deficiency

Expression for Pyridoxine Deficiency

Search GEO for disease gene expression data for Pyridoxine Deficiency.

Pathways for Pyridoxine Deficiency

Pathways related to Pyridoxine Deficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.96 GSR SHMT2

GO Terms for Pyridoxine Deficiency

Cellular components related to Pyridoxine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 8.96 GSR SHMT2
2 mitochondrial matrix GO:0005759 8.62 GSR SHMT2

Sources for Pyridoxine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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