MCID: PYR009
MIFTS: 37

Pyridoxine Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases

Aliases & Classifications for Pyridoxine Deficiency Anemia

Summaries for Pyridoxine Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin B6), and has material basis in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid).

MalaCards based summary : Pyridoxine Deficiency Anemia, also known as vitamin b 6 deficiency, is related to kwashiorkor and liver disease. An important gene associated with Pyridoxine Deficiency Anemia is CBS (Cystathionine-Beta-Synthase), and among its related pathways/superpathways is Carbon metabolism. The drugs Folic Acid and Pyridoxine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart.

Wikipedia : 77 Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological... more...

Related Diseases for Pyridoxine Deficiency Anemia

Diseases related to Pyridoxine Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 29.7 GPT SLC17A5
2 liver disease 29.6 GPT SLC17A5
3 alcohol abuse 29.5 GPT SLC17A5
4 pyridoxine deficiency 29.4 CBS GPT SLC17A5
5 pyridoxamine 5-prime-phosphate oxidase deficiency 11.3
6 homocysteinemia 10.2
7 deficiency anemia 10.1
8 uremia 10.1
9 tinea unguium 10.0 CBS GPT
10 cataract 10.0
11 bladder cancer 9.9
12 carpal tunnel syndrome 9.9
13 rheumatoid arthritis 9.9
14 hyperprolinemia, type ii 9.9
15 asplenia, isolated congenital 9.9
16 aging 9.9
17 sickle cell anemia 9.9
18 mononeuropathy of the median nerve, mild 9.9
19 arthritis 9.9
20 common variable immunodeficiency 9.9
21 crohn's disease 9.9
22 leukemia 9.9
23 lymphoid leukemia 9.9
24 atrial fibrillation 9.9
25 omphalocele 9.9
26 nephrotic syndrome 9.9
27 nephrocalcinosis 9.9
28 urogenital tuberculosis 9.9
29 dental caries 9.9
30 macrocytic anemia 9.9
31 angular blepharoconjunctivitis 9.9
32 blepharoconjunctivitis 9.9
33 bronchus adenoma 9.9
34 adenoma 9.9
35 axonal neuropathy 9.9
36 pellagra 9.9
37 neuropathy 9.9
38 sideroblastic anemia 9.9
39 meningitis 9.9
40 carcinoid syndrome 9.9
41 hyperprolinemia 9.9
42 depression 9.9
43 cystathioninuria 9.9
44 paraquat poisoning 9.9 GPT SLC17A5
45 infantile liver failure syndrome 1 9.9 GPT SLC17A5
46 nonalcoholic steatohepatitis 9.9 GPT SLC17A5
47 hepatitis 9.9 GPT SLC17A5
48 fascioliasis 9.8 GPT SLC17A5
49 fatty liver disease, nonalcoholic 1 9.8 GPT SLC17A5
50 choledocholithiasis 9.8 GPT SLC17A5

Graphical network of the top 20 diseases related to Pyridoxine Deficiency Anemia:



Diseases related to Pyridoxine Deficiency Anemia

Symptoms & Phenotypes for Pyridoxine Deficiency Anemia

Drugs & Therapeutics for Pyridoxine Deficiency Anemia

Drugs for Pyridoxine Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Not Applicable 59-30-3 6037
2
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 65-23-6 1054
3
Methionine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 63-68-3 6137
4
Serine Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 56-45-1 5951
5 Vitamin B 6 Phase 2, Phase 3,Not Applicable
6 Vitamin B Complex Phase 2, Phase 3,Not Applicable
7 Vitamins Phase 2, Phase 3,Not Applicable
8 Trace Elements Phase 2, Phase 3,Not Applicable
9 Contraceptive Agents Phase 2, Phase 3
10 Vitamin B9 Phase 2, Phase 3,Not Applicable
11 Micronutrients Phase 2, Phase 3,Not Applicable
12 leucine Phase 2, Phase 3,Not Applicable
13 Folate Phase 2, Phase 3,Not Applicable
14 Contraceptives, Oral, Combined Phase 2, Phase 3
15 Contraceptives, Oral Phase 2, Phase 3
16 Nutrients Phase 2, Phase 3,Not Applicable
17
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3,Not Applicable 66-72-8 1050
18
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
19
leucovorin Approved Not Applicable 58-05-9 143 6006
20
Glycine Approved, Nutraceutical, Vet_approved Not Applicable 56-40-6 750
21
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
22
Cobalamin Experimental Not Applicable 13408-78-1 6857388
23 Neurotransmitter Agents Not Applicable
24 Vitamin B12 Not Applicable
25 Vitamin B 12 Not Applicable
26 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects for Women Taking Birth Control Pills Completed NCT01128244 Phase 2, Phase 3
2 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812 Not Applicable
3 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275
4 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Pyridoxine Deficiency Anemia

Cochrane evidence based reviews: vitamin b 6 deficiency

Genetic Tests for Pyridoxine Deficiency Anemia

Anatomical Context for Pyridoxine Deficiency Anemia

MalaCards organs/tissues related to Pyridoxine Deficiency Anemia:

42
Brain, Kidney, Heart, Cerebellum, Olfactory Bulb

Publications for Pyridoxine Deficiency Anemia

Articles related to Pyridoxine Deficiency Anemia:

(show top 50) (show all 67)
# Title Authors Year
1
Vitamin B-6 deficiency is common and associated with poor long-term outcome in renal transplant recipients. ( 28468895 )
2017
2
Involvement of 5-methyltetrahydrofolate in the amelioration of hyperhomocysteinemia caused by vitamin B(6) deficiency and L-methionine supplementation. ( 23391913 )
2013
3
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. ( 23776431 )
2013
4
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. ( 23902960 )
2013
5
Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond. ( 23985806 )
2013
6
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. ( 22955512 )
2012
7
Is vitamin B(6) deficiency an under-recognized risk in patients receiving haemodialysis? A systematic review: 2000-2010. ( 21609363 )
2011
8
Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states. ( 20403077 )
2010
9
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. ( 19244383 )
2009
10
Effect of vitamin B(6) deficiency on antioxidative status in rats with exercise-induced oxidative stress. ( 20090886 )
2009
11
Role of vitamin b(6) deficiency in the nitrogen balance of streptozotocin-diabetic rats. ( 20020950 )
2007
12
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. ( 16857832 )
2006
13
Vitamin B-6 deficiency prolongs the time course of evoked dopamine release from rat striatum. ( 15570036 )
2004
14
Hydrolytic activity toward pyridoxine-5'-beta-D-glucoside in rat intestinal mucosa is not increased by vitamin B-6 deficiency: effect of basal diet composition and pyridoxine intake. ( 12730423 )
2003
15
Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. ( 10801907 )
2000
16
Vitamin B-6 deficiency and level of dietary protein affect hepatic tyrosine aminotransferase activity in cats. ( 9808655 )
1998
17
Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities. ( 7529303 )
1995
18
Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. ( 8172087 )
1994
19
Vitamin B-6 deficiency alters rat enterocyte calcium homeostasis but not duodenal transport. ( 8429369 )
1993
20
Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations. ( 1595588 )
1992
21
Cytotoxicity of 3-hydroxykynurenine: implications for CNS damage in neonatal vitamin B-6 deficiency. ( 1772096 )
1991
22
Pathology associated with vitamin B-6 deficiency in growing kittens. ( 1834817 )
1991
23
Vitamin B-6 deficiency and renal function and structure in chronically uremic rats. ( 2008872 )
1991
24
Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. ( 2021134 )
1991
25
Effects of vitamin B-6 deficiency on selenium metabolism in the rat. ( 2621489 )
1989
26
Effects of copper and vitamin B-6 deficiency on taste sensitivity in the rat: a signal detection analysis. ( 2813538 )
1989
27
The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency. ( 2850579 )
1988
28
Effect of dietary vitamin B-6 deficiency on calcium fluxes in rat enterocytes. ( 3347631 )
1988
29
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats. ( 3123763 )
1987
30
Functional and metabolic consequences of vitamin B-6 deficiency in the rat heart. ( 3797426 )
1987
31
Effect of vitamin B-6 deficiency on plasma amino acid levels in chronically azotemic rats. ( 3772516 )
1986
32
Humoral immunity in chicks experiencing marginal vitamin B-6 deficiency. ( 6693994 )
1984
33
The effect of vitamin B-6 deficiency on host susceptibility to Moloney sarcoma virus-induced tumor growth in mice. ( 6726463 )
1984
34
Effects of sugars and vitamin B-6 deficiency on oxalate synthesis in rats. ( 6747727 )
1984
35
Effect of maternal vitamin B-6 deficiency on specific regions of developing rat brain: amino acid metabolism. ( 6834146 )
1983
36
Effects of maternal vitamin B-6 deficiency on specific regions of developing rat brain: the extrapyramidal motor system. ( 6834147 )
1983
37
The effects of vitamin B-6 deficiency and hepatectomy on the synthesis of oxalate from glycolate in the rat. ( 6838900 )
1983
38
Accumulation of homocyst(e)ine in vitamin B-6 deficiency: a model for the study of cystathionine beta-synthase deficiency. ( 7097345 )
1982
39
Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. ( 6961425 )
1982
40
Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat. ( 6257871 )
1981
41
Effects of vitamin B-6 deficiency during lactation on the vitamin B-6 content of milk, liver and muscle of rats. ( 7218033 )
1981
42
Effects of vitamin B-6 deficiency on morphological changes in dendritic trees of Purkinje cells in developing cerebellum of rats. ( 7229735 )
1981
43
Effect of vitamin B-6 deficiency on preference for several taste solutions in the rat. ( 430235 )
1979
44
Effect of vitamin B-6 deficiency on glutamic acid decarboxylase activity in rat olfactory bulb and brain. ( 490207 )
1979
45
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Gross measurements and cytoarchitectural alterations. ( 671092 )
1978
46
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Myelination. ( 671093 )
1978
47
Effects of vitamin B-6 deficiency and tryptophan loading on urinary excretion of tryptophan metabolites in mammals. ( 833687 )
1977
48
Vitamin B-6 deficiency in germfree rats. ( 894368 )
1977
49
The effect of vitamin B-6 deficiency on the fatty acid composition of the major phospholipids in the rat. ( 1249643 )
1976
50
Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency. ( 4416751 )
1974

Variations for Pyridoxine Deficiency Anemia

Expression for Pyridoxine Deficiency Anemia

Search GEO for disease gene expression data for Pyridoxine Deficiency Anemia.

Pathways for Pyridoxine Deficiency Anemia

Pathways related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.95 CBS GPT

GO Terms for Pyridoxine Deficiency Anemia

Biological processes related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.62 CBS GPT

Molecular functions related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 CBS GPT

Sources for Pyridoxine Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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