MCID: PYR009
MIFTS: 35

Pyridoxine Deficiency Anemia

Categories: Metabolic diseases

Aliases & Classifications for Pyridoxine Deficiency Anemia

MalaCards integrated aliases for Pyridoxine Deficiency Anemia:

Name: Pyridoxine Deficiency Anemia 12 15
Vitamin B 6 Deficiency 44 70
Vitamin B6 Deficiency 73 54
Anemia Due to Vitamin B>6< Deficiency 70
Vitamin B6 Deficiency Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8455
ICD9CM 34 266.1
MeSH 44 D026681
NCIt 50 C85221
SNOMED-CT 67 18881008
ICD10 32 E53.1
UMLS 70 C0272013 C0936215

Summaries for Pyridoxine Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin B6), and has material basis in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid).

MalaCards based summary : Pyridoxine Deficiency Anemia, also known as vitamin b 6 deficiency, is related to kwashiorkor and homocysteinemia. An important gene associated with Pyridoxine Deficiency Anemia is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are FOXA2 and FOXA3 transcription factor networks and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Pyridoxine and Methionine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney.

Wikipedia : 73 Vitamin B6 is one of the B vitamins, and thus an essential nutrient. The term refers to a group of... more...

Related Diseases for Pyridoxine Deficiency Anemia

Diseases related to Pyridoxine Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 29.8 SLC17A5 GPT F2
2 homocysteinemia 29.7 VCAM1 F2 CBS
3 exanthem 29.6 GPT F2 ACE
4 glucose intolerance 29.6 IGFBP1 GPT ACE
5 arteriosclerosis 29.4 VCAM1 GPT ACE
6 liver cirrhosis 29.3 SLC17A5 GPT F2 ACE
7 chronic kidney disease 29.0 VCAM1 IGFBP1 ACE
8 sickle cell anemia 29.0 VCAM1 GPT F2 ACE
9 diabetes mellitus 28.5 VCAM1 IGFBP1 GPT F2 ACE
10 pyridoxamine 5-prime-phosphate oxidase deficiency 11.2
11 seizure disorder 10.4
12 uremia 10.3
13 deficiency anemia 10.2
14 pyridoxine deficiency 10.2
15 carpal tunnel syndrome 10.2
16 polyneuropathy 10.2
17 paraquat poisoning 10.2 SLC17A5 GPT
18 parenteral nutrition-associated cholestasis 10.2 SLC17A5 GPT
19 methotrexate toxicity 10.2 SLC17A5 GPT
20 rocky mountain spotted fever 10.2 SLC17A5 GPT
21 fascioliasis 10.1 SLC17A5 GPT
22 scrub typhus 10.1 SLC17A5 GPT
23 cystathioninuria 10.1
24 neuroblastoma 10.1
25 homocystinuria 10.1
26 emphysematous cholecystitis 10.1 GPT F2
27 cholecystitis 10.1 GPT F2
28 ankylosing spondylitis 1 10.1 GPT F2
29 acalculous cholecystitis 10.1 GPT F2
30 hepatic infarction 10.1 GPT F2
31 splenic abscess 10.1 GPT F2
32 ascending cholangitis 10.1 GPT F2
33 peliosis hepatis 10.1 GPT F2
34 alcohol dependence 10.1
35 parkinson disease, late-onset 10.1
36 urolithiasis 10.1
37 iron metabolism disease 10.1
38 skin disease 10.1
39 peripheral nervous system disease 10.1
40 pellagra 10.1
41 sideroblastic anemia 10.1
42 paralytic ileus 10.1 GPT F2
43 acute cholangitis 10.1 GPT F2
44 common bile duct disease 10.1 GPT F2
45 hepatic coma 10.1 GPT F2
46 abdominal tuberculosis 10.1 GPT F2
47 splenic infarction 10.1 GPT F2
48 pyuria 10.1 GPT F2
49 pleural empyema 10.1 GPT F2
50 klatskin's tumor 10.1 GPT F2

Graphical network of the top 20 diseases related to Pyridoxine Deficiency Anemia:



Diseases related to Pyridoxine Deficiency Anemia

Symptoms & Phenotypes for Pyridoxine Deficiency Anemia

Drugs & Therapeutics for Pyridoxine Deficiency Anemia

Drugs for Pyridoxine Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
2
Methionine Approved, Nutraceutical Phase 2, Phase 3 63-68-3 6137
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4 Vitamin B 6 Phase 2, Phase 3
5 Vitamin B Complex Phase 2, Phase 3
6 Vitamins Phase 2, Phase 3
7 Trace Elements Phase 2, Phase 3
8 Vitamin B9 Phase 2, Phase 3
9 Nutrients Phase 2, Phase 3
10 Contraceptive Agents Phase 2, Phase 3
11 Folate Phase 2, Phase 3
12 Contraceptives, Oral, Combined Phase 2, Phase 3
13 Micronutrients Phase 2, Phase 3
14 Contraceptives, Oral Phase 2, Phase 3
15
Serine Investigational, Nutraceutical Phase 2, Phase 3 56-45-1 5951
16
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
17
Leucine Investigational, Nutraceutical Phase 2, Phase 3 61-90-5 6106
18
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
19
Levoleucovorin Approved, Investigational 68538-85-2 149436
20
Glycine Approved, Nutraceutical, Vet_approved 56-40-6 750
21
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
22
Cobalamin Experimental 13408-78-1 6857388
23 Neurotransmitter Agents
24 Hematinics
25 Vitamin B12
26 Vitamin B 12

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects on One-Carbon Metabolism Completed NCT01128244 Phase 2, Phase 3
2 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812
3 Pilot Study for the Evaluation of the Effectiveness of Natural Versus Synthetic Vitamin B Complexes in Humans. Completed NCT03444155
4 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275

Search NIH Clinical Center for Pyridoxine Deficiency Anemia

Cochrane evidence based reviews: vitamin b 6 deficiency

Genetic Tests for Pyridoxine Deficiency Anemia

Anatomical Context for Pyridoxine Deficiency Anemia

MalaCards organs/tissues related to Pyridoxine Deficiency Anemia:

40
Liver, Heart, Kidney, Skeletal Muscle, Uterus, Bone Marrow, Spleen

Publications for Pyridoxine Deficiency Anemia

Articles related to Pyridoxine Deficiency Anemia:

(show top 50) (show all 496)
# Title Authors PMID Year
1
Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. 61 54
7557098 1995
2
The pathogenesis of decreased aspartate aminotransferase and alanine aminotransferase activity in the plasma of hemodialysis patients: the role of vitamin B6 deficiency. 61 54
7554526 1995
3
Low serum aminotransferase activity in patients undergoing regular hemodialysis. 61 54
8022112 1994
4
Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice. 61
33772108 2021
5
Nutrient Intake Adequacy from Food and Beverage Intake of US Children Aged 1-6 Years from NHANES 2001-2016. 61
33802295 2021
6
The Role of Vitamin B6 in Women's Health. 61
33549283 2021
7
Erythropoietin-stimulating agent-resistant vitamin B6 deficiency anemia in a pediatric patient on hemodialysis. 61
33156411 2021
8
Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults. 61
33521527 2020
9
Development and Clinical Evaluation of a High-Throughput LC-MS/MS Assay for Vitamin B6 in Human Plasma and Serum. 61
33279978 2020
10
Dietary Vitamin B6 Deficiency Impairs Gut Microbiota and Host and Microbial Metabolites in Rats. 61
33147768 2020
11
The relationship between plasma albumin, alkaline phosphatase and pyridoxal phosphate concentrations in plasma and red cells: Implications for assessing vitamin B6 status. 61
31883613 2020
12
Vitamin B6 Deficiency in Patients With Parkinson Disease Treated With Levodopa/Carbidopa. 61
32947426 2020
13
A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma. 61
32346589 2020
14
Pearls and Oy-sters: Vitamin B6 deficiency presenting with new-onset epilepsy and status epilepticus in a patient with Parkinson disease. 61
32467131 2020
15
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study. 61
31129702 2020
16
Hypophosphatasia: Biological and Clinical Aspects, Avenues for Therapy. 61
32158059 2020
17
Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons. 61
32053107 2020
18
Vitamin B6 deficiency in new born rats affects hepatic cardiolipin composition and oxidative phosphorylation. 61
31752529 2019
19
Food fortification with multiple micronutrients: impact on health outcomes in general population. 61
31849042 2019
20
Vitamin B6 deficiency is prevalent in primary and secondary myelofibrosis patients. 61
31407257 2019
21
Association of low alanine aminotransferase with loss of independence or death: A 5-year population-based cohort study. 61
30761612 2019
22
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
23
Accumulation of Liver Lipids Induced by Vitamin B6 Deficiency Was Effectively Ameliorated by Choline and, to a Lesser Extent, Betaine. 61
30814419 2019
24
Vitamin B6 blood concentrations in paediatric dialysis patients. 61
30128792 2018
25
High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment. 61
30800953 2018
26
[Vitamin B6 deficiency caused by the use of levodopa]. 61
30212001 2018
27
A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. 61
29290084 2017
28
Vitamin B6 is essential for serine de novo biosynthesis. 61
28801717 2017
29
Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats. 61
28912874 2017
30
The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. 61
28716455 2017
31
Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats. 61
27696964 2017
32
Vitamin B6 metabolism in microbes and approaches for fermentative production. 61
27890703 2017
33
Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. 61
28367454 2017
34
Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial. 61
27475338 2016
35
Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions. 61
26765812 2016
36
Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. 61
27642461 2016
37
High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. 61
26745680 2016
38
Ginkgotoxin Induced Seizure Caused by Vitamin B6 Deficiency. 61
26819944 2015
39
Vitamin B6 intoxication after inappropriate supplementation with micronutrients following bariatric surgery. 61
26039319 2015
40
Seizures Related to Vitamin B6 Deficiency in Adults. 61
26157671 2015
41
Effects of maternal vitamin B6 deficiency and over-supplementation on DNA damage and oxidative stress in rat dams and their offspring. 61
25818462 2015
42
Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency. 61
25381637 2015
43
Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. 61
25635989 2015
44
A rare mutation in EIF2B4 gene in an epileptic child with vanishing white matter disease: a case report. 61
26043506 2015
45
[Sufficiency with water-soluble vitamins and state of bone in pregnant women]. 61
26863809 2015
46
Clinical Forms and Animal Models of Hypophosphatasia. 61
26219704 2015
47
Vitamin B6 in plasma and cerebrospinal fluid of children. 61
25760040 2015
48
Anemia attributed to vitamin B6 deficiency in post-pancreaticoduodenectomy patients. 61
25543166 2015
49
Evaluation of vitamin B6 intake and status of 20- to 64-year-old Koreans. 61
25489409 2014
50
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review. 61
25343127 2014

Variations for Pyridoxine Deficiency Anemia

Expression for Pyridoxine Deficiency Anemia

Search GEO for disease gene expression data for Pyridoxine Deficiency Anemia.

Pathways for Pyridoxine Deficiency Anemia

Pathways related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.6 IGFBP1 F2
2 9.95 IGFBP1 F2

GO Terms for Pyridoxine Deficiency Anemia

Cellular components related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 VCAM1 F2 ACE
2 extracellular space GO:0005615 9.02 VCAM1 IGFBP1 GPT F2 ACE

Biological processes related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.62 GPT CBS

Molecular functions related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 GPT CBS

Sources for Pyridoxine Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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