MCID: PYR009
MIFTS: 32

Pyridoxine Deficiency Anemia

Categories: Metabolic diseases

Aliases & Classifications for Pyridoxine Deficiency Anemia

MalaCards integrated aliases for Pyridoxine Deficiency Anemia:

Name: Pyridoxine Deficiency Anemia 12
Vitamin B 6 Deficiency 44 72
Vitamin B6 Deficiency 75 55
Anemia Due to Vitamin B>6< Deficiency 72
Vitamin B6 Deficiency Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8455
ICD9CM 35 266.1
MeSH 44 D026681
NCIt 50 C85221
SNOMED-CT 68 18881008
ICD10 33 E53.1
UMLS 72 C0272013 C0936215

Summaries for Pyridoxine Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin B6), and has material basis in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid).

MalaCards based summary : Pyridoxine Deficiency Anemia, also known as vitamin b 6 deficiency, is related to kwashiorkor and liver disease. An important gene associated with Pyridoxine Deficiency Anemia is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways is Carbon metabolism. The drugs Folic acid and Serine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes.

Wikipedia : 75 Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological... more...

Related Diseases for Pyridoxine Deficiency Anemia

Diseases related to Pyridoxine Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 29.6 SLC17A5 GPT
2 liver disease 29.5 SLC17A5 GPT
3 pyridoxine deficiency 29.2 SLC17A5 GPT CBS
4 liver cirrhosis 29.1 SLC17A5 GPT
5 pyridoxamine 5-prime-phosphate oxidase deficiency 11.4
6 visual epilepsy 10.4
7 seizure disorder 10.4
8 deficiency anemia 10.3
9 homocysteinemia 10.2
10 alcohol dependence 10.2
11 carpal tunnel syndrome 10.2
12 polyneuropathy 10.2
13 uremia 10.2
14 iron metabolism disease 10.1
15 skin disease 10.1
16 peripheral nervous system disease 10.1
17 pellagra 10.1
18 neuropathy 10.1
19 sideroblastic anemia 10.1
20 encephalopathy 10.1
21 cystathioninuria 10.0
22 neuroblastoma 1 10.0
23 cataract 10.0
24 epilepsy, pyridoxine-dependent 10.0
25 tinea unguium 9.9 GPT CBS
26 bladder cancer 9.9
27 cleft palate, isolated 9.9
28 acrodermatitis enteropathica, zinc-deficiency type 9.9
29 anemia, hypochromic microcytic, with iron overload 1 9.9
30 monosodium glutamate sensitivity 9.9
31 hemochromatosis, type 1 9.9
32 hyperprolinemia, type ii 9.9
33 immune deficiency disease 9.9
34 myelofibrosis 9.9
35 proteasome-associated autoinflammatory syndrome 1 9.9
36 pulmonary alveolar microlithiasis 9.9
37 ataxia and polyneuropathy, adult-onset 9.9
38 sickle cell anemia 9.9
39 body mass index quantitative trait locus 1 9.9
40 epileptic encephalopathy, early infantile, 6 9.9
41 coronary heart disease 1 9.9
42 membranous nephropathy 9.9
43 exanthem 9.9
44 hypochromic microcytic anemia 9.9
45 atrioventricular block 9.9
46 atrial fibrillation 9.9
47 angular cheilitis 9.9
48 omphalocele 9.9
49 hyperprolinemia 9.9
50 interstitial nephritis 9.9

Graphical network of the top 20 diseases related to Pyridoxine Deficiency Anemia:



Diseases related to Pyridoxine Deficiency Anemia

Symptoms & Phenotypes for Pyridoxine Deficiency Anemia

Drugs & Therapeutics for Pyridoxine Deficiency Anemia

Drugs for Pyridoxine Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
2
Serine Approved, Nutraceutical Phase 2, Phase 3 56-45-1 5951
3
Methionine Approved, Nutraceutical Phase 2, Phase 3 63-68-3 6137
4
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
5 Vitamins Phase 2, Phase 3
6 Nutrients Phase 2, Phase 3
7 Vitamin B Complex Phase 2, Phase 3
8 Micronutrients Phase 2, Phase 3
9 Trace Elements Phase 2, Phase 3
10 Contraceptives, Oral Phase 2, Phase 3
11 Contraceptives, Oral, Combined Phase 2, Phase 3
12 Contraceptive Agents Phase 2, Phase 3
13 Vitamin B9 Phase 2, Phase 3
14 Folate Phase 2, Phase 3
15 Vitamin B 6 Phase 2, Phase 3
16 leucine Phase 2, Phase 3
17
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
18
leucovorin Approved 58-05-9 143 6006
19
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
20
Glycine Approved, Nutraceutical, Vet_approved 56-40-6 750
21
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
22
Cobalamin Experimental 13408-78-1 6857388
23 Neurotransmitter Agents
24 Hematinics
25 Vitamin B 12
26 Vitamin B12

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects on One-Carbon Metabolism Completed NCT01128244 Phase 2, Phase 3
2 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275
3 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812
4 Pilot Study for the Evaluation of the Effectiveness of Natural Versus Synthetic Vitamin B Complexes in Humans. Completed NCT03444155

Search NIH Clinical Center for Pyridoxine Deficiency Anemia

Cochrane evidence based reviews: vitamin b 6 deficiency

Genetic Tests for Pyridoxine Deficiency Anemia

Anatomical Context for Pyridoxine Deficiency Anemia

MalaCards organs/tissues related to Pyridoxine Deficiency Anemia:

41
Liver, Brain, Testes, Heart, Skin, Bone, Kidney

Publications for Pyridoxine Deficiency Anemia

Articles related to Pyridoxine Deficiency Anemia:

(show top 50) (show all 481)
# Title Authors PMID Year
1
Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. 9 38
7557098 1995
2
The pathogenesis of decreased aspartate aminotransferase and alanine aminotransferase activity in the plasma of hemodialysis patients: the role of vitamin B6 deficiency. 9 38
7554526 1995
3
Low serum aminotransferase activity in patients undergoing regular hemodialysis. 9 38
8022112 1994
4
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 38
31377720 2019
5
Vitamin B6 deficiency is prevalent in primary and secondary myelofibrosis patients. 38
31407257 2019
6
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study. 38
31129702 2019
7
Association of low alanine aminotransferase with loss of independence or death: A 5-year population-based cohort study. 38
30761612 2019
8
Accumulation of Liver Lipids Induced by Vitamin B6 Deficiency Was Effectively Ameliorated by Choline and, to a Lesser Extent, Betaine. 38
30814419 2019
9
Vitamin B6 blood concentrations in paediatric dialysis patients. 38
30128792 2018
10
High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment. 38
30800953 2018
11
[Vitamin B6 deficiency caused by the use of levodopa]. 38
30212001 2018
12
A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. 38
29290084 2017
13
Vitamin B6 is essential for serine de novo biosynthesis. 38
28801717 2017
14
Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats. 38
28912874 2017
15
The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. 38
28716455 2017
16
Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats. 38
27696964 2017
17
Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. 38
28367454 2017
18
Vitamin B6 metabolism in microbes and approaches for fermentative production. 38
27890703 2017
19
Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial. 38
27475338 2016
20
Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions. 38
26765812 2016
21
High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. 38
26745680 2016
22
Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. 38
27642461 2016
23
Ginkgotoxin Induced Seizure Caused by Vitamin B6 Deficiency. 38
26819944 2015
24
Vitamin B6 intoxication after inappropriate supplementation with micronutrients following bariatric surgery. 38
26039319 2015
25
Seizures Related to Vitamin B6 Deficiency in Adults. 38
26157671 2015
26
Effects of maternal vitamin B6 deficiency and over-supplementation on DNA damage and oxidative stress in rat dams and their offspring. 38
25818462 2015
27
Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency. 38
25381637 2015
28
Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. 38
25635989 2015
29
A rare mutation in EIF2B4 gene in an epileptic child with vanishing white matter disease: a case report. 38
26043506 2015
30
Vitamin B6 in plasma and cerebrospinal fluid of children. 38
25760040 2015
31
Anemia attributed to vitamin B6 deficiency in post-pancreaticoduodenectomy patients. 38
25543166 2015
32
[Sufficiency with water-soluble vitamins and state of bone in pregnant women]. 38
26863809 2015
33
Clinical Forms and Animal Models of Hypophosphatasia. 38
26219704 2015
34
Evaluation of vitamin B6 intake and status of 20- to 64-year-old Koreans. 38
25489409 2014
35
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review. 38
25343127 2014
36
Atypical vitamin B6 deficiency: a rare cause of unexplained neonatal and infantile epilepsies. 38
24114605 2014
37
Sugar and chromosome stability: clastogenic effects of sugars in vitamin B6-deficient cells. 38
24651653 2014
38
Power calculation for overall hypothesis testing with high-dimensional commensurate outcomes. 38
24122945 2014
39
Convulsive seizures with a therapeutic dose of isoniazid. 38
24492693 2014
40
Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. 38
24183308 2013
41
Vitamin B6: deficiency diseases and methods of analysis. 38
24035968 2013
42
Kynurenines and vitamin B6: link between diabetes and depression. 38
25401165 2013
43
Assessment of intake and nutritional status of vitamin b1, b2, and b6 in men and women with different physical activity levels. 38
24744477 2013
44
Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. 38
23394203 2013
45
Refractory epileptic seizures due to vitamin B6 deficiency in a patient with Parkinson's disease under duodopa® therapy. 38
22798026 2013
46
An Epidemiologic Investigation of Potential Risk Factors for Nodding Syndrome in Kitgum District, Uganda. 38
23823012 2013
47
Water-soluble vitamin deficiencies in complicated peptic ulcer patients soon after ulcer onset in Japan. 38
24477246 2013
48
High incidence of lipid deposition in the liver of rats fed a diet supplemented with branched-chain amino acids under vitamin B6 deficiency. 38
23535543 2013
49
Vitamin B6 and the immunity in kidney transplant recipients. 38
22445054 2013
50
Influence of mineral and vitamin supplements on pregnancy outcome. 38
22771225 2012

Variations for Pyridoxine Deficiency Anemia

Expression for Pyridoxine Deficiency Anemia

Search GEO for disease gene expression data for Pyridoxine Deficiency Anemia.

Pathways for Pyridoxine Deficiency Anemia

Pathways related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.95 GPT CBS

GO Terms for Pyridoxine Deficiency Anemia

Biological processes related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.62 CBS GPT

Molecular functions related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 GPT CBS

Sources for Pyridoxine Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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