MCID: PYR009
MIFTS: 34

Pyridoxine Deficiency Anemia

Categories: Metabolic diseases

Aliases & Classifications for Pyridoxine Deficiency Anemia

MalaCards integrated aliases for Pyridoxine Deficiency Anemia:

Name: Pyridoxine Deficiency Anemia 12 15
Vitamin B 6 Deficiency 43 71
Vitamin B6 Deficiency 74 54
Anemia Due to Vitamin B>6< Deficiency 71
Vitamin B6 Deficiency Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8455
ICD9CM 34 266.1
MeSH 43 D026681
NCIt 49 C85221
SNOMED-CT 67 386080007
ICD10 32 E53.1
UMLS 71 C0272013 C0936215

Summaries for Pyridoxine Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin B6), and has material basis in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid).

MalaCards based summary : Pyridoxine Deficiency Anemia, also known as vitamin b 6 deficiency, is related to homocysteinemia and kwashiorkor. An important gene associated with Pyridoxine Deficiency Anemia is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Folate Metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Folic acid and Methionine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes.

Wikipedia : 74 Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological... more...

Related Diseases for Pyridoxine Deficiency Anemia

Diseases related to Pyridoxine Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 homocysteinemia 29.8 VCAM1 F2 CBS
2 kwashiorkor 29.7 SLC17A5 GPT F2
3 liver cirrhosis 29.7 SLC17A5 GPT F2
4 exanthem 29.4 GPT F2 ACE
5 arteriosclerosis 28.9 VCAM1 GPT ACE
6 pyridoxamine 5-prime-phosphate oxidase deficiency 11.4
7 visual epilepsy 10.4
8 seizure disorder 10.4
9 paraquat poisoning 10.3 SLC17A5 GPT
10 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.3
11 deficiency anemia 10.3
12 pyridoxine deficiency 10.3
13 parenteral nutrition-associated cholestasis 10.3 SLC17A5 GPT
14 myxedema 10.3 SEM1 FHL2
15 methotrexate toxicity 10.2 SLC17A5 GPT
16 fatty liver disease, nonalcoholic 1 10.2 SLC17A5 GPT
17 rocky mountain spotted fever 10.2 SLC17A5 GPT
18 alcohol dependence 10.2
19 carpal tunnel syndrome 10.2
20 urolithiasis 10.2
21 polyneuropathy 10.2
22 uremia 10.2
23 fascioliasis 10.2 SLC17A5 GPT
24 scrub typhus 10.1 SLC17A5 GPT
25 emphysematous cholecystitis 10.1 GPT F2
26 hepatic tuberculosis 10.1 GPT F2
27 ascending cholangitis 10.1 GPT F2
28 hepatic infarction 10.1 GPT F2
29 ankylosing spondylitis 1 10.1 GPT F2
30 splenic abscess 10.1 GPT F2
31 acalculous cholecystitis 10.1 GPT F2
32 acute cholangitis 10.1 GPT F2
33 splenic infarction 10.1 GPT F2
34 iron metabolism disease 10.1
35 skin disease 10.1
36 peripheral nervous system disease 10.1
37 pellagra 10.1
38 neuropathy 10.1
39 sideroblastic anemia 10.1
40 encephalopathy 10.1
41 abdominal tuberculosis 10.1 GPT F2
42 paralytic ileus 10.1 GPT F2
43 hepatic coma 10.1 GPT F2
44 common bile duct disease 10.1 GPT F2
45 pyuria 10.1 GPT F2
46 esophageal varix 10.1 GPT F2
47 pancreas lymphoma 10.1 GPT ACE
48 vitamin b12 deficiency 10.1 GPT CBLIF
49 cystathioninuria 10.0
50 neuroblastoma 10.0

Graphical network of the top 20 diseases related to Pyridoxine Deficiency Anemia:



Diseases related to Pyridoxine Deficiency Anemia

Symptoms & Phenotypes for Pyridoxine Deficiency Anemia

Drugs & Therapeutics for Pyridoxine Deficiency Anemia

Drugs for Pyridoxine Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
2
Methionine Approved, Nutraceutical Phase 2, Phase 3 63-68-3 6137
3
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
4 Vitamins Phase 2, Phase 3
5 Vitamin B Complex Phase 2, Phase 3
6 Trace Elements Phase 2, Phase 3
7 Vitamin B 6 Phase 2, Phase 3
8 Contraceptives, Oral, Combined Phase 2, Phase 3
9 Contraceptives, Oral Phase 2, Phase 3
10 Contraceptive Agents Phase 2, Phase 3
11 Nutrients Phase 2, Phase 3
12 Folate Phase 2, Phase 3
13 Micronutrients Phase 2, Phase 3
14 Vitamin B9 Phase 2, Phase 3
15
Serine Investigational, Nutraceutical Phase 2, Phase 3 56-45-1 5951
16
Leucine Investigational, Nutraceutical Phase 2, Phase 3 61-90-5 6106
17
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
18
leucovorin Approved 58-05-9 6006 143
19
Hydroxocobalamin Approved 13422-51-0 15589840 11953898
20
Glycine Approved, Nutraceutical, Vet_approved 56-40-6 750
21
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
22
Cobalamin Experimental 13408-78-1 6857388
23 Neurotransmitter Agents
24 Vitamin B 12
25 Hematinics
26 Vitamin B12

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin B6 Effects on One-Carbon Metabolism Completed NCT01128244 Phase 2, Phase 3
2 The Vitamin B Status in Type 2 Diabetes (VITA) Study Completed NCT03447275
3 Vitamin B6 Dependence of One-Carbon Metabolism Completed NCT00877812
4 Pilot Study for the Evaluation of the Effectiveness of Natural Versus Synthetic Vitamin B Complexes in Humans. Completed NCT03444155

Search NIH Clinical Center for Pyridoxine Deficiency Anemia

Cochrane evidence based reviews: vitamin b 6 deficiency

Genetic Tests for Pyridoxine Deficiency Anemia

Anatomical Context for Pyridoxine Deficiency Anemia

MalaCards organs/tissues related to Pyridoxine Deficiency Anemia:

40
Liver, Brain, Testes, Heart, Skin, Bone, Kidney

Publications for Pyridoxine Deficiency Anemia

Articles related to Pyridoxine Deficiency Anemia:

(show top 50) (show all 488)
# Title Authors PMID Year
1
Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. 61 54
7557098 1995
2
The pathogenesis of decreased aspartate aminotransferase and alanine aminotransferase activity in the plasma of hemodialysis patients: the role of vitamin B6 deficiency. 54 61
7554526 1995
3
Low serum aminotransferase activity in patients undergoing regular hemodialysis. 61 54
8022112 1994
4
A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma. 61
32346589 2020
5
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study. 61
31129702 2020
6
Pearls and Oy-sters: Vitamin B6 deficiency presenting with new-onset epilepsy and status epilepticus in a patient with Parkinson disease. 61
32467131 2020
7
Hypophosphatasia: Biological and Clinical Aspects, Avenues for Therapy. 61
32158059 2020
8
Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons. 61
32053107 2020
9
The relationship between plasma albumin, alkaline phosphatase and pyridoxal phosphate concentrations in plasma and red cells: Implications for assessing vitamin B6 status. 61
31883613 2019
10
Food fortification with multiple micronutrients: impact on health outcomes in general population. 61
31849042 2019
11
Vitamin B6 deficiency in new born rats affects hepatic cardiolipin composition and oxidative phosphorylation. 61
31752529 2019
12
Vitamin B6 deficiency is prevalent in primary and secondary myelofibrosis patients. 61
31407257 2019
13
Association of low alanine aminotransferase with loss of independence or death: A 5-year population-based cohort study. 61
30761612 2019
14
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
15
Accumulation of Liver Lipids Induced by Vitamin B6 Deficiency Was Effectively Ameliorated by Choline and, to a Lesser Extent, Betaine. 61
30814419 2019
16
Vitamin B6 blood concentrations in paediatric dialysis patients. 61
30128792 2018
17
High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment. 61
30800953 2018
18
[Vitamin B6 deficiency caused by the use of levodopa]. 61
30212001 2018
19
A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. 61
29290084 2017
20
Vitamin B6 is essential for serine de novo biosynthesis. 61
28801717 2017
21
The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. 61
28716455 2017
22
Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats. 61
28912874 2017
23
Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats. 61
27696964 2017
24
Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. 61
28367454 2017
25
Vitamin B6 metabolism in microbes and approaches for fermentative production. 61
27890703 2017
26
Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial. 61
27475338 2016
27
Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions. 61
26765812 2016
28
High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. 61
26745680 2016
29
Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. 61
27642461 2016
30
Ginkgotoxin Induced Seizure Caused by Vitamin B6 Deficiency. 61
26819944 2015
31
Vitamin B6 intoxication after inappropriate supplementation with micronutrients following bariatric surgery. 61
26039319 2015
32
Seizures Related to Vitamin B6 Deficiency in Adults. 61
26157671 2015
33
Effects of maternal vitamin B6 deficiency and over-supplementation on DNA damage and oxidative stress in rat dams and their offspring. 61
25818462 2015
34
Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency. 61
25381637 2015
35
Anemia attributed to vitamin B6 deficiency in post-pancreaticoduodenectomy patients. 61
25543166 2015
36
A rare mutation in EIF2B4 gene in an epileptic child with vanishing white matter disease: a case report. 61
26043506 2015
37
Vitamin B6 in plasma and cerebrospinal fluid of children. 61
25760040 2015
38
Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. 61
25635989 2015
39
Clinical Forms and Animal Models of Hypophosphatasia. 61
26219704 2015
40
[Sufficiency with water-soluble vitamins and state of bone in pregnant women]. 61
26863809 2015
41
Evaluation of vitamin B6 intake and status of 20- to 64-year-old Koreans. 61
25489409 2014
42
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review. 61
25343127 2014
43
Atypical vitamin B6 deficiency: a rare cause of unexplained neonatal and infantile epilepsies. 61
24114605 2014
44
Sugar and chromosome stability: clastogenic effects of sugars in vitamin B6-deficient cells. 61
24651653 2014
45
Power calculation for overall hypothesis testing with high-dimensional commensurate outcomes. 61
24122945 2014
46
Convulsive seizures with a therapeutic dose of isoniazid. 61
24492693 2014
47
Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. 61
24183308 2013
48
Vitamin B6: deficiency diseases and methods of analysis. 61
24035968 2013
49
Kynurenines and vitamin B6: link between diabetes and depression. 61
25401165 2013
50
Assessment of intake and nutritional status of vitamin b1, b2, and b6 in men and women with different physical activity levels. 61
24744477 2013

Variations for Pyridoxine Deficiency Anemia

Expression for Pyridoxine Deficiency Anemia

Search GEO for disease gene expression data for Pyridoxine Deficiency Anemia.

Pathways for Pyridoxine Deficiency Anemia

Pathways related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.46 F2 CBS CBLIF
2 10.8 IGFBP1 F2
3 9.95 IGFBP1 F2

GO Terms for Pyridoxine Deficiency Anemia

Cellular components related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 VCAM1 IGFBP1 GPT F2 CBLIF ACE

Biological processes related to Pyridoxine Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.62 GPT CBS

Sources for Pyridoxine Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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