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MCID: PYR008
MIFTS: 31

Pyriform Sinus Cancer

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Pyriform Sinus Cancer

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MalaCards integrated aliases for Pyriform Sinus Cancer:

Name: Pyriform Sinus Cancer 12 15
Malignant Neoplasm of the Pyriform Fossa 12
Malignant Neoplasm of Pyriform Fossa 12
Malignant Tumor of Pyriform Fossa 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9235
ICD9CM 34 148.1
NCIt 50 C3531
SNOMED-CT 67 363401000
ICD10 32 C12
UMLS 70 C0153400
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Summaries for Pyriform Sinus Cancer

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MalaCards based summary : Pyriform Sinus Cancer, also known as malignant neoplasm of the pyriform fossa, is related to sinus cancer and glottis squamous cell carcinoma. An important gene associated with Pyriform Sinus Cancer is CNDP2 (Carnosine Dipeptidase 2), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include lymph node, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

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Related Diseases for Pyriform Sinus Cancer

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Diseases related to Pyriform Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 sinus cancer 10.8
2 glottis squamous cell carcinoma 10.2 MAP3K5 JUN
3 acquired hemangioma 10.2 PECAM1 LYVE1
4 combined hepatocellular carcinoma and cholangiocarcinoma 10.2 MTOR EIF4EBP1
5 intramuscular hemangioma 10.2 PECAM1 LYVE1
6 48,xyyy 10.2
7 heart sarcoma 10.2 SSX2 PECAM1
8 hobnail hemangioma 10.1 PECAM1 FLT4
9 breast angiosarcoma 10.1 PECAM1 FLT4
10 capillary lymphangioma 10.1 PECAM1 LYVE1 FLT4
11 congenital lymphedema 10.1 VEGFC FLT4
12 lymphangiosarcoma 10.1 PECAM1 LYVE1 FLT4
13 capillary hemangioma 10.0 PECAM1 LYVE1 FLT4
14 primary lymphedema 10.0 VEGFC FLT4
15 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
16 hypopharynx cancer 10.0
17 supraglottic laryngeal cancer 10.0
18 acute sensory ataxic neuropathy 10.0
19 kaposiform hemangioendothelioma 10.0 PECAM1 MTOR FLT4
20 chylothorax, congenital 10.0 VEGFC LYVE1 FLT4
21 lymphocele 10.0 VEGFC MTOR LYVE1
22 lymphedema-distichiasis syndrome 10.0 VEGFC LYVE1 FLT4
23 lymphatic malformation 1 9.9 VEGFC FLT4
24 benign ependymoma 9.9 RPS6KB1 MTOR EIF4EBP1
25 heart cancer 9.9 PECAM1 MTOR
26 muscle hypertrophy 9.9 RPS6KB1 MTOR EIF4EBP1
27 keratitis, hereditary 9.9 VEGFC PECAM1 LYVE1
28 gorham's disease 9.8 VEGFC PECAM1 LYVE1 FLT4
29 lymphangitis 9.8 VEGFC PECAM1 LYVE1 FLT4
30 kidney angiomyolipoma 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
31 subependymal glioma 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
32 hemangioma 9.8 PECAM1 MTOR LYVE1 FLT4
33 tuberous sclerosis 1 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
34 lymphangioma 9.8 VEGFC PECAM1 LYVE1 FLT4
35 tuberous sclerosis 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
36 tuberous sclerosis 2 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
37 breast carcinoma in situ 9.8 VEGFC FLT4 EGF
38 cowden syndrome 9.8 RPS6KB1 RPS6 MTOR EIF4EBP1
39 hennekam syndrome 9.7 VEGFC LYVE1 FLT4 EGF
40 lymphangioleiomyomatosis 9.7 VEGFC RPS6KB1 RPS6 MTOR
41 exudative vitreoretinopathy 1 9.6 VEGFC PECAM1 MTOR
42 macular degeneration, age-related, 1 9.5 VEGFC PECAM1 FLT4 EYS EGF
43 rhabdomyosarcoma 9.5 SSX2 RPS6KB1 PMAIP1 MTOR EIF4EBP1
44 lung cancer susceptibility 3 9.5 VEGFC PECAM1 JUN FLT4 EGF
45 mantle cell lymphoma 9.4 RPS6KB1 PMAIP1 MTOR EIF4EBP1 BCL2L11
46 renal cell carcinoma, nonpapillary 9.2 VEGFC PECAM1 MTOR JUN FLT4 EIF4EBP1
47 gastric cancer 8.8 VEGFC RPS6KB1 MTOR JUN FLT4 EIF4EBP1
48 pancreatic cancer 8.6 VEGFC RPS6KB1 MTOR JUN FLT4 EIF4EBP1
49 leukemia, acute myeloid 8.6 RPS6KB1 PMAIP1 MTOR JUN EIF4EBP1 EGF

Graphical network of the top 20 diseases related to Pyriform Sinus Cancer:



Diseases related to Pyriform Sinus Cancer
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Symptoms & Phenotypes for Pyriform Sinus Cancer

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GenomeRNAi Phenotypes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.02 MTOR RPS6KB1
2 Decreased viability with paclitaxel GR00179-A-2 9.02 MTOR
3 Decreased viability with paclitaxel GR00179-A-3 9.02 MTOR RPS6KB1

MGI Mouse Phenotypes related to Pyriform Sinus Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 BCL2L11 CNDP2 EIF4EBP1 FLT4 JUN LYVE1
2 immune system MP:0005387 9.36 BCL2L11 CNDP2 DNTT EGF FLT4 JUN
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Drugs & Therapeutics for Pyriform Sinus Cancer

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Search Clinical Trials , NIH Clinical Center for Pyriform Sinus Cancer

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Genetic Tests for Pyriform Sinus Cancer

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Anatomical Context for Pyriform Sinus Cancer

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MalaCards organs/tissues related to Pyriform Sinus Cancer:

40
Lymph Node
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Publications for Pyriform Sinus Cancer

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Articles related to Pyriform Sinus Cancer:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Outcomes of Patients Undergoing Emergency Tracheostomy During COVID 19 Pandemic: Our Experience from a Tertiary Care Centre in North-East India. 61
33686367 2021
2
Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study. 61
30409296 2018
3
Combined transoral-transhyoid endoscopic approach for hypopharyngeal cancer. 61
29402609 2018
4
Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer. 61
30464497 2018
5
[Surgical management of elderly patients with medial wall pyriform sinus cancer]. 61
29262511 2017
6
Therapeutic Management of Pyriform Sinus Cancer. 61
28072556 2017
7
Transoral robotic surgery for early T classification hypopharyngeal cancer. 61
26559383 2016
8
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. 61
25804347 2015
9
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study. 61
24849707 2014
10
[Treatment of pyriform sinus carcinoma involving the lateral wall]. 61
23886091 2013
11
Fluorodeoxyglucose-induced allergic reaction: a case report. 61
22267446 2013
12
[Musculomucosal flaps of posterior laryngopharynx wall for reconstruction after resection of pyriform sinus cancer]. 61
23700813 2013
13
Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. 61
24244346 2013
14
Necessity of routine ipsilateral hemithyroidectomy during laryngopharyngectomy for pyriform sinus cancer. 61
22382374 2012
15
Laminin-5 immunohistochemical mapping for analysis of local extension in hypopharyngeal cancer: A preliminary report. 61
21871747 2012
16
Free jejunal graft for esophageal reconstruction using end-to-side vascular anastomosis and extended pharyngo-jejunostomy. 61
22440367 2012
17
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options. 61
23107977 2012
18
Preservation of laryngeal functions in surgical treatment of pyriform sinus carcinoma. 61
21133828 2011
19
[Clinical analysis of surgical complications after preoperative concurrent chemoradiotherapy of pyriform sinus cancer]. 61
21426704 2011
20
Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. 61
20582549 2010
21
Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. 61
20619721 2010
22
[Treatment and clinical analysis of laryngeal function preserving surgery in hypopharyngeal carcinoma]. 61
20359116 2009
23
[Applied study of voice function rehabilitation by mucosa tube performed in operation of late laryngocarcinoma.]. 61
20079073 2009
24
Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. 61
19671141 2009
25
[Laryngeal function preserving surgery in hypopharyngeal carcinoma]. 61
19954017 2009
26
Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. 61
18804408 2009
27
[Early detection of recurrent hypopharyngeal cancer after radiotherapy by utilizing narrow-band imaging--report of a case]. 61
18018596 2007
28
[Preservation of laryngeal function in treatment of pyriform sinus carcinoma]. 61
17441428 2007
29
Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. 61
16920307 2006
30
[Surgical treatment on primary lesion of advanced pyriform sinus cancer]. 61
16995308 2006
31
[Comprehensive treatment of advanced pyriform sinus cancer]. 61
16671524 2006
32
[Cervical lymph node metastasis of hypopharyngeal carcinoma]. 61
16408732 2005
33
[Treatment and survival analysis of pyriform sinus cancer]. 61
16270875 2005
34
[Preservation of laryngeal function in surgical treatment of pyriform sinus carcinoma]. 61
15952574 2005
35
Correlation of local outcome after partial laryngectomy with cartilage abnormalities on CT. 61
15760887 2005
36
Conservation laryngeal surgery for selected pyriform sinus cancer. 61
15522562 2004
37
[Hypopharynx reconstruction of defects after operation on advanced pyriform sinus cancer with remaining laryngeal mucosa flap and pectoralis major myocutaneous flap]. 61
15323445 2004
38
[Preservation of laryngeal function in surgery for medial wall pyriform sinus cancer]. 61
12515629 2002
39
[Preservative surgery of medial wall pyriform sinus cancer]. 61
12761989 2001
40
[Laryngeal function-sparing surgery for pyriform sinus cancer]. 61
12768706 2000
41
Larynx preservation surgery in pyriform sinus cancer. 61
11071322 2000
42
Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. 61
9874427 1998
43
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. 61
8656441 1996
44
Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer. 61
8693597 1996
45
Outcome of pyriform sinus cancer: a retrospective institutional review. 61
8544623 1996
46
Prognostic factors for local control in hypopharyngeal cancer treated with radical irradiation. 61
8571184 1996
47
Laryngotracheal flap for reconstruction of hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. 61
7712839 1995
48
Reconstruction of the hypopharynx using hemilarynx for localized pyriform sinus cancer. 61
7968173 1994
49
Prevertebral fascia flap in hypopharyngeal reconstruction: a preliminary report. 61
8491322 1993
50
Hemipharyngectomy and hemilaryngectomy for pyriform sinus cancer: reconstruction with remaining larynx and hypopharynx and with tracheostomy. 61
8421425 1993
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Variations for Pyriform Sinus Cancer

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Expression for Pyriform Sinus Cancer

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Search GEO for disease gene expression data for Pyriform Sinus Cancer.
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Pathways for Pyriform Sinus Cancer

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Pathways related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 63
Show member pathways
 13.5 VEGFC RPS6KB1 RPS6 MTOR MAP3K5 JUN
2
Akt Signaling 63
Show member pathways
 13.39 VEGFC RPS6KB1 MTOR MAP3K5 FLT4 EIF4EBP1
3
p70S6K Signaling 63
Show member pathways
 12.96 VEGFC RPS6KB1 RPS6 MTOR JUN FLT4
4
Regulation of lipid metabolism Insulin signaling-generic cascades 23
Show member pathways
 12.89 RPS6KB1 RPS6 MTOR JUN EIF4EBP1 EGF
5
Focal Adhesion 36 1
Show member pathways
 12.87 VEGFC MAP3K5 JUN FLT4 EGF
6
NFAT and Cardiac Hypertrophy 63
Show member pathways
 12.84 RPS6KB1 RPS6 MTOR MAP3K5 JUN
7
PI3K-Akt signaling pathway 36
Show member pathways
 12.84 VEGFC RPS6KB1 RPS6 MTOR FLT4 EIF4EBP1
8
Endometrial cancer 36
Show member pathways
 12.8 RPS6KB1 PMAIP1 MTOR JUN EIF4EBP1 EGF
9
Beta-Adrenergic Signaling 63
Show member pathways
 12.78 RPS6KB1 RPS6 MTOR JUN EIF4EBP1
10
MAPK signaling pathway 36 1
12.74 VEGFC MAP3K5 JUN FLT4 EGF
11
Gastric cancer 36
Show member pathways
 12.74 RPS6KB1 MTOR JUN FLT4 EGF
12
Angiopoietin Like Protein 8 Regulatory Pathway 1
Show member pathways
 12.51 RPS6KB1 MTOR MAP3K5 JUN EIF4EBP1
13
mTOR signaling pathway (KEGG) 36
Show member pathways
 12.49 RPS6KB1 RPS6 MTOR FLT4 EIF4EBP1
14
VEGF Signaling 66
Show member pathways
 12.48 VEGFC MTOR JUN EGF
15
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.46 RPS6KB1 RPS6 MTOR EIF4EBP1
16
Prolactin Signaling Pathway 1 36
Show member pathways
 12.45 RPS6KB1 RPS6 MTOR JUN EIF4EBP1
17
VEGF Pathway (Qiagen) 63
Show member pathways
 12.39 VEGFC JUN FLT4 EGF
18
mTOR signalling 65
Show member pathways
 12.39 RPS6KB1 RPS6 MTOR EIF4EBP1
19
RhoGDI Pathway 63
Show member pathways
 12.37 VEGFC JUN FLT4 EGF
20
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.37 VEGFC RPS6KB1 MTOR JUN FLT4 EGF
21
Phospholipase D signaling pathway 36
Show member pathways
 12.37 RPS6KB1 MTOR JUN EIF4EBP1 EGF
22
ErbB signaling pathway 36 1
Show member pathways
 12.36 RPS6KB1 RPS6 MTOR JUN EIF4EBP1 EGF
23
CNTF Signaling 63
Show member pathways
 12.32 RPS6KB1 MTOR JUN EIF4EBP1
24
Development IGF-1 receptor signaling 23
Show member pathways
 12.32 RPS6KB1 RPS6 MTOR MAP3K5 EIF4EBP1 BCL2L11
25
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.29 RPS6KB1 MTOR EIF4EBP1 EGF
26
Pathways in cancer 36
12.28 VEGFC RPS6KB1 PMAIP1 MTOR JUN FLT4
27
Translational Control 4
12.25 RPS6KB1 RPS6 MTOR EIF4EBP1
28
EGF/EGFR Signaling Pathway 1
12.14 RPS6KB1 MTOR JUN EIF4EBP1 EGF
29
UVA-Induced MAPK Signaling 63
Show member pathways
 12.06 RPS6KB1 MTOR JUN EIF4EBP1
30
Translation Translation regulation by Alpha-1 adrenergic receptors 23
Show member pathways
 12 RPS6KB1 MTOR JUN EIF4EBP1
31
DNA Damage Response (only ATM dependent) 1
11.96 PMAIP1 JUN BCL2L11
32
TNF signaling pathway 36
11.95 VEGFC MAP3K5 JUN
33
Glioblastoma Multiforme 63
11.94 RPS6KB1 MTOR EGF
34
ErbB1 downstream signaling 1
11.91 RPS6 MTOR JUN EGF
35
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 11.88 RPS6KB1 RPS6 MTOR MAP3K5 FLT4 EIF4EBP1
36
HIF-1 signaling pathway 36
11.87 RPS6KB1 RPS6 MTOR EIF4EBP1 EGF
37
TGF-beta Signaling Pathways 64
11.86 RPS6KB1 MTOR JUN
38
Angiogenesis (CST) 4
11.82 VEGFC PECAM1 FLT4
39
MAPK Signaling: Oxidative Stress Pathway 64
11.76 MAP3K5 JUN BCL2L11
40
Interferon Pathway 63
11.73 RPS6KB1 RPS6 MTOR MAP3K5 EIF4EBP1
41
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.68 RPS6KB1 RPS6 MTOR JUN
42
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.67 RPS6KB1 RPS6 MTOR
43
Regulation of Telomerase 1
11.66 RPS6KB1 MTOR JUN EGF
44
mTOR signaling pathway (Pathway Interaction Database) 1
11.62 RPS6KB1 MTOR EIF4EBP1
45
Photodynamic therapy-induced AP-1 survival signaling. 1
11.54 MAP3K5 JUN BCL2L11
46
Interferon type I signaling pathways 1
11.54 RPS6KB1 RPS6 MTOR EIF4EBP1
47
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.5 RPS6 MTOR EIF4EBP1
48
Vemurafenib Pathway, Pharmacodynamics 60
11.46 JUN FLT4 EGF
49
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins 23
Show member pathways
 11.42 PMAIP1 MAP3K5 JUN BCL2L11
50
Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics 60
11.4 RPS6KB1 MTOR JUN
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GO Terms for Pyriform Sinus Cancer

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Cellular components related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic cytosol GO:0099524 8.96 MTOR EIF4EBP1
2 mitochondrial outer membrane GO:0005741 8.92 RPS6KB1 PMAIP1 MTOR BCL2L11

Biological processes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 VEGFC RPS6 JUN FLT4 EGF
2 angiogenesis GO:0001525 9.76 VEGFC JUN FLT4 EGF
3 G1/S transition of mitotic cell cycle GO:0000082 9.69 RPS6KB1 RPS6 EIF4EBP1
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 PECAM1 MTOR EGF
5 positive regulation of apoptotic process GO:0043065 9.65 RPS6 PMAIP1 MAP3K5 JUN BCL2L11
6 positive regulation of protein phosphorylation GO:0001934 9.55 VEGFC PECAM1 MTOR MAP3K5 FLT4
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.54 RPS6KB1 MTOR JUN
8 vascular endothelial growth factor signaling pathway GO:0038084 9.52 VEGFC FLT4
9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.5 PMAIP1 MAP3K5 BCL2L11
10 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902237 9.43 PMAIP1 BCL2L11
11 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 9.4 PMAIP1 BCL2L11
12 positive regulation of endothelial cell proliferation GO:0001938 9.26 VEGFC MTOR FLT4 EGF
13 TOR signaling GO:0031929 8.92 RPS6KB1 RPS6 MTOR EIF4EBP1
Sources

Sources for Pyriform Sinus Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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