Pyriform Sinus Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Pyriform Sinus Cancer, also known as malignant neoplasm of the pyriform fossa, is related to sinus cancer and acquired hemangioma. An important gene associated with Pyriform Sinus Cancer is POU3F1 (POU Class 3 Homeobox 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include lymph node, and related phenotypes are Decreased viability with paclitaxel and Reduced mammosphere formation

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Related Diseases for Pyriform Sinus Cancer

Diseases related to Pyriform Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)

#	Related Disease	Score	Top Affiliating Genes
1	sinus cancer	10.8
2	acquired hemangioma	10.2	PECAM1 LYVE1
3	intramuscular hemangioma	10.2	PECAM1 LYVE1
4	ovarian angiosarcoma	10.2	SSX2 PECAM1
5	kidney hemangiopericytoma	10.2	SSX2 PECAM1
6	48,xyyy	10.2
7	heart sarcoma	10.2	SSX2 PECAM1
8	epithelioid hemangioendothelioma	10.1	PECAM1 FLT4
9	glottis squamous cell carcinoma	10.1	MAP3K5 EGFR
10	rapidly involuting congenital hemangioma	10.1	PECAM1 FLT4
11	breast angiosarcoma	10.1	PECAM1 FLT4
12	hobnail hemangioma	10.1	PECAM1 FLT4
13	heart leiomyosarcoma	10.1	PECAM1 EGFR
14	childhood angiosarcoma	10.0	PECAM1 FLT4
15	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.0
16	rhabdomyosarcoma 2	10.0
17	spastic paraplegia, ataxia, and mental retardation	10.0
18	head and neck cancer	10.0
19	larynx cancer	10.0
20	laryngeal benign neoplasm	10.0
21	hypopharynx cancer	10.0
22	49, xxxxy syndrome	10.0
23	ring chromosome 22	10.0
24	supraglottic laryngeal cancer	10.0
25	acute sensory ataxic neuropathy	10.0
26	lymphangiosarcoma	10.0	PECAM1 LYVE1 FLT4
27	capillary lymphangioma	10.0	PECAM1 LYVE1 FLT4
28	pyogenic granuloma	10.0	PECAM1 LYVE1 FLT4
29	urethra transitional cell carcinoma	10.0	FLT4 EGFR
30	congenital lymphedema	10.0	VEGFC FLT4
31	lung carcinoma in situ	10.0	EGFR EGF
32	chylothorax, congenital	10.0	VEGFC FLT4
33	mixed cell adenoma	9.9	EGFR EGF
34	corneal disease	9.9	PECAM1 LYVE1 EGF
35	pulmonary adenocarcinoma in situ	9.9	EGFR EGF
36	cystic lymphangioma	9.9	PECAM1 FLT4
37	familiar ovarian carcinoma	9.9	VEGFC FLT4
38	hereditary lymphedema	9.9	VEGFC LYVE1 FLT4
39	hereditary lymphedema i	9.9	VEGFC LYVE1 FLT4
40	lymphedema-distichiasis syndrome	9.9	VEGFC LYVE1 FLT4
41	elephantiasis	9.9	VEGFC FLT4
42	brain glioblastoma multiforme	9.9	EGFR EGF
43	keratitis, hereditary	9.9	VEGFC PECAM1 LYVE1
44	inflammatory breast carcinoma	9.9	VEGFC LYVE1 EGFR
45	amelogenesis imperfecta, type ig	9.8	JUN EGFR EGF
46	gastroesophageal junction adenocarcinoma	9.8	VEGFC EGFR
47	primary lymphedema	9.8	VEGFC FLT4
48	kidney angiomyolipoma	9.8	RPS6 MTOR EIF4EBP1
49	subependymal glioma	9.8	RPS6 MTOR EIF4EBP1
50	acneiform dermatitis	9.8	MTOR EGFR

Graphical network of the top 20 diseases related to Pyriform Sinus Cancer:

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Symptoms & Phenotypes for Pyriform Sinus Cancer

GenomeRNAi Phenotypes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.15	CLDN11 CNDP2 EGF EGFR EIF4EBP1 EYS
2	no effect	GR00402-S-2	10.15	CLDN11 CNDP2 EGF EGFR EIF4EBP1 EYS
3	Decreased viability with paclitaxel	GR00179-A-1	9.55	EGFR MTOR
4	Decreased viability with paclitaxel	GR00179-A-2	9.55	MTOR
5	Decreased viability with paclitaxel	GR00179-A-3	9.55	EGFR MTOR
6	Reduced mammosphere formation	GR00396-S	9.43	CLDN11 EGFR EIF4EBP1 JUN MTOR RPS6

MGI Mouse Phenotypes related to Pyriform Sinus Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.97	CLDN11 EGFR EIF4EBP1 FLT4 JUN KCNE1
2	cardiovascular system	MP:0005385	9.7	CNDP2 EGFR EIF4EBP1 FLT4 JUN KCNE1
3	immune system	MP:0005387	9.4	CNDP2 EGF EGFR FLT4 JUN KCNE1

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Drugs & Therapeutics for Pyriform Sinus Cancer

Search Clinical Trials, NIH Clinical Center for Pyriform Sinus Cancer

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Genetic Tests for Pyriform Sinus Cancer

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Anatomical Context for Pyriform Sinus Cancer

Organs/tissues related to Pyriform Sinus Cancer:

MalaCards : Lymph Node

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Publications for Pyriform Sinus Cancer

Articles related to Pyriform Sinus Cancer:

(show top 50) (show all 62)

#	Title	Authors	PMID	Year
1	Outcomes of Patients Undergoing Emergency Tracheostomy During COVID 19 Pandemic: Our Experience from a Tertiary Care Centre in North-East India. ⁶²	Khanna S...Dey R	33686367	2022
2	Lymph node ratio predicts recurrence-free survival and disease-specific survival of patients with pyriform sinus squamous cell carcinoma. ⁶²	Liu Y...Liu S	36184282	2022
3	Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes. ⁶²	Xu S...Liu J	34825265	2022
4	A domain knowledge enhanced yield based deep learning classifier identifies perineural invasion in oral cavity squamous cell carcinoma. ⁶²	Lee LY...Liao CT	36353548	2022
5	Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study. ⁶²	Mazerolle P...Vergez S	30409296	2018
6	Combined transoral-transhyoid endoscopic approach for hypopharyngeal cancer. ⁶²	Honda K...Kimura T	29402609	2018
7	Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer. ⁶²	Wang Q...Zhang M	30464497	2018
8	[Surgical management of elderly patients with medial wall pyriform sinus cancer]. ⁶²	Wang Q...Zhao Y	29262511	2017
9	Therapeutic Management of Pyriform Sinus Cancer. ⁶²	Donnadieu J...Page C	28072556	2017
10	Transoral robotic surgery for early T classification hypopharyngeal cancer. ⁶²	Wang CC...Lin JC	26559383	2016
11	Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. ⁶²	Sakashita T...Fukuda S	25804347	2015
12	A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study. ⁶²	Ceruse P...Fayette J	24849707	2014
13	[Treatment of pyriform sinus carcinoma involving the lateral wall]. ⁶²	Song XC...Song YP	23886091	2013
14	Fluorodeoxyglucose-induced allergic reaction: a case report. ⁶²	Codreanu I...Divgi C	22267446	2013
15	[Musculomucosal flaps of posterior laryngopharynx wall for reconstruction after resection of pyriform sinus cancer]. ⁶²	Yu A...Luo L	23700813	2013
16	Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. ⁶²	Joo YH...Kim MS	24244346	2013
17	Necessity of routine ipsilateral hemithyroidectomy during laryngopharyngectomy for pyriform sinus cancer. ⁶²	Ozgursoy OB...Jacobs JR	22382374	2012
18	Free jejunal graft for esophageal reconstruction using end-to-side vascular anastomosis and extended pharyngo-jejunostomy. ⁶²	Lee HS...Zo JI	22440367	2012
19	Laminin-5 immunohistochemical mapping for analysis of local extension in hypopharyngeal cancer: A preliminary report. ⁶²	Nakayama M...Miyamoto S	21871747	2012
20	Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options. ⁶²	Krstevska V	23107977	2012
21	Preservation of laryngeal functions in surgical treatment of pyriform sinus carcinoma. ⁶²	Li XZ...Pan XL	21133828	2011
22	[Clinical analysis of surgical complications after preoperative concurrent chemoradiotherapy of pyriform sinus cancer]. ⁶²	Huang H...Wang XL	21426704	2011
23	Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. ⁶²	Wu PY...Su CY	20582549	2010
24	Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. ⁶²	Park YM...Kim SH	20619721	2010
25	[Treatment and clinical analysis of laryngeal function preserving surgery in hypopharyngeal carcinoma]. ⁶²	Li J...Guo Z	20359116	2009
26	[Applied study of voice function rehabilitation by mucosa tube performed in operation of late laryngocarcinoma.]. ⁶²	Shan XZ...Jia XQ	20079073	2009
27	Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. ⁶²	Papacharalampous GX...Manolopoulos L	19671141	2009
28	[Laryngeal function preserving surgery in hypopharyngeal carcinoma]. ⁶²	Li JX...Guo ZX	19954017	2009
29	Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. ⁶²	Lu H...Tan H	18804408	2009
30	[Early detection of recurrent hypopharyngeal cancer after radiotherapy by utilizing narrow-band imaging--report of a case]. ⁶²	Watanabe A...Sasaki S	18018596	2007
31	[Preservation of laryngeal function in treatment of pyriform sinus carcinoma]. ⁶²	Xu Z...Wei L	17441428	2007
32	Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. ⁶²	Walvekar RR...D'Cruz AK	16920307	2006
33	[Surgical treatment on primary lesion of advanced pyriform sinus cancer]. ⁶²	Wang XL...Tang PZ	16995308	2006
34	[Comprehensive treatment of advanced pyriform sinus cancer]. ⁶²	Wang XL...Tang PZ	16671524	2006
35	[Cervical lymph node metastasis of hypopharyngeal carcinoma]. ⁶²	Guo X...Pan ZM	16408732	2005
36	[Treatment and survival analysis of pyriform sinus cancer]. ⁶²	Shang JB...Ge MH	16270875	2005
37	[Preservation of laryngeal function in surgical treatment of pyriform sinus carcinoma]. ⁶²	Li XZ...Wang TD	15952574	2005
38	Correlation of local outcome after partial laryngectomy with cartilage abnormalities on CT. ⁶²	Thoeny HC...Hermans R	15760887	2005
39	Conservation laryngeal surgery for selected pyriform sinus cancer. ⁶²	Plouin-Gaudon I...Hamoir M	15522562	2004
40	[Hypopharynx reconstruction of defects after operation on advanced pyriform sinus cancer with remaining laryngeal mucosa flap and pectoralis major myocutaneous flap]. ⁶²	Hu G...Zhu J	15323445	2004
41	[Preservation of laryngeal function in surgery for medial wall pyriform sinus cancer]. ⁶²	Zhang L...Yang Q	12515629	2002
42	[Preservative surgery of medial wall pyriform sinus cancer]. ⁶²	Huang J...Wang T	12761989	2001
43	[Laryngeal function-sparing surgery for pyriform sinus cancer]. ⁶²	Wang X...Tang P	12768706	2000
44	Larynx preservation surgery in pyriform sinus cancer. ⁶²	Yoo SJ...Kim SY	11071322	2000
45	Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. ⁶²	Miguel RE...Kowalski LP	9874427	1998
46	Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. ⁶²	Lefebvre JL...Sahmoud T	8656441	1996
47	Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer. ⁶²	Grau JJ...Traserra J	8693597	1996
48	Outcome of pyriform sinus cancer: a retrospective institutional review. ⁶²	Marks SC...Jacobs JR	8544623	1996
49	Prognostic factors for local control in hypopharyngeal cancer treated with radical irradiation. ⁶²	Toita T...Yamaguchi K	8571184	1996
50	Laryngotracheal flap for reconstruction of hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. ⁶²	Li A...Wang T	7712839	1995

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Genes for Pyriform Sinus Cancer

Genes related to Pyriform Sinus Cancer (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POU3F1	POU Class 3 Homeobox 1	Protein Coding	5.88	DISEASES inferred ¹⁴
2	CNDP2	Carnosine Dipeptidase 2	Protein Coding	5.48	DISEASES inferred ¹⁴
3	LYVE1	Lymphatic Vessel Endothelial Hyaluronan Receptor 1	Protein Coding	5.25	DISEASES inferred ¹⁴
4	EYS	Eyes Shut Homolog	Protein Coding	4.55	DISEASES inferred ¹⁴
5	CLDN11	Claudin 11	Protein Coding	4.08	DISEASES inferred ¹⁴
6	KCNE1	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1	Protein Coding	3.84	DISEASES inferred ¹⁴
7	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	3.82	DISEASES inferred ¹⁴
8	SSX2	SSX Family Member 2	Protein Coding	3.74	DISEASES inferred ¹⁴
9	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3.54	DISEASES inferred ¹⁴
10	RPS6	Ribosomal Protein S6	Protein Coding	3.41	DISEASES inferred ¹⁴
11	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	3.26	DISEASES inferred ¹⁴
12	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	3.2	DISEASES inferred ¹⁴
13	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	3.18	DISEASES inferred ¹⁴
14	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	3.08	DISEASES inferred ¹⁴
15	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2.99	DISEASES inferred ¹⁴
16	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	2.95	DISEASES inferred ¹⁴
17	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2.94	DISEASES inferred ¹⁴
18	EGF	Epidermal Growth Factor	Protein Coding	2.88	DISEASES inferred ¹⁴

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Variations for Pyriform Sinus Cancer

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Expression for Pyriform Sinus Cancer

Search GEO for disease gene expression data for Pyriform Sinus Cancer.

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Pathways for Pyriform Sinus Cancer

Pathways related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.77	VEGFC PMAIP1 MTOR MAP3K5 JUN FLT4
2	Signal Transduction ⁶⁶	13.74	VEGFC RPS6 MTOR JUN FLT4 EIF4EBP1
3	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.42	RPS6 MTOR MAP3K5 JUN EIF4EBP1 EGFR
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.4	EGF EGFR EIF4EBP1 FLT4 JUN MAP3K5
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.33	VEGFC MTOR MAP3K5 FLT4 EIF4EBP1 EGFR
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.25	VEGFC MAP3K5 JUN FLT4 EGFR EGF
7	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.21	VEGFC MAP3K5 JUN FLT4 EGFR EGF
8	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.83	PMAIP1 MTOR MAP3K5 JUN EGFR EGF
9	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.8	RPS6 MTOR MAP3K5 JUN EGFR
10	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.77	VEGFC MTOR FLT4 EGFR EGF
11	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.63	VEGFC MAP3K5 FLT4 EGFR EGF
12	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.62	PMAIP1 MTOR JUN EGFR EGF
13	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.61	VEGFC MAP3K5 JUN EGFR
14	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.61	MAP3K5 JUN EGFR EGF
15	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.61	VEGFC RPS6 MTOR FLT4 EIF4EBP1 EGFR
16	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.58	VEGFC MTOR FLT4 EGFR EGF
17	Translation Insulin regulation of translation ²² Show member pathways Butyrate-induced histone acetylation ⁷⁴ Cell adhesion PLAU signaling ²² Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 ⁷⁴ Regulation of lipid metabolism Insulin signaling-generic cascades ²² Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation inhibitors in chronically activated PDGFRA cells ⁷⁴	12.58	RPS6 MTOR JUN EIF4EBP1 EGFR EGF
18	Angiopoietin-like protein 8 regulatory pathway ⁷⁴ Show member pathways Insulin signaling ⁷⁴ Liver X receptor pathway ⁷⁴	12.46	EIF4EBP1 JUN MAP3K5 MTOR
19	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	12.44	VEGFC RPS6 MTOR JUN FLT4 EIF4EBP1
20	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.43	MTOR JUN EGFR EGF
21	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.37	EGFR FLT4 JUN MTOR
22	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.37	MTOR JUN FLT4 EGFR EGF
23	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF and VEGFR signaling network ⁶¹ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.36	VEGFC JUN FLT4 EGFR EGF
24	MAPK signaling pathway ⁷⁴	12.34	MAP3K5 JUN EGFR EGF
25	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.3	VEGFC JUN FLT4 EGFR EGF
26	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.26	VEGFC MTOR JUN FLT4 EGFR EGF
27	Focal adhesion ⁷⁴	12.22	EGF EGFR JUN VEGFC
28	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.19	RPS6 MTOR MAP3K5 EIF4EBP1
29	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.14	RPS6 MTOR FLT4 EIF4EBP1 EGFR
30	Tyrosine Kinases / Adaptors ³	12.06	VEGFC FLT4 EGFR EGF
31	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.05	EGF EGFR EIF4EBP1 MTOR
32	PDGFR-beta signaling pathway ⁶¹ Show member pathways ErbB1 downstream signaling ⁶¹	12.05	EGF EGFR JUN MTOR RPS6
33	MTOR signalling ⁶⁶ Show member pathways Energy dependent regulation of mTOR by LKB1-AMPK ⁶⁶ Inhibition of TSC complex formation by PKB ⁶⁶ mTORC1-mediated signalling ⁶⁶ Target of rapamycin signaling ⁷⁴	12.02	RPS6 MTOR EIF4EBP1
34	mTOR Signaling ⁶⁵	12.02	MTOR FLT4 EIF4EBP1 EGFR
35	Direct p53 effectors ⁶¹	12	PMAIP1 JUN EGFR
36	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	11.97	MTOR JUN EIF4EBP1
37	IL2 signaling events mediated by STAT5 ⁶¹ Show member pathways IL2 signaling events mediated by PI3K ⁶¹ IL2-mediated signaling events ⁶¹ Interleukin-2 signaling ⁶⁶	11.97	RPS6 MTOR JUN
38	Thermogenesis ⁷⁴ Show member pathways mitochondrial L-carnitine shuttle ⁶¹	11.93	RPS6 MTOR MAP3K5
39	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²²	11.92	JUN EGFR EGF
40	Gastrin signaling pathway ⁷⁴	11.9	RPS6 JUN EIF4EBP1 EGFR
41	Malignant pleural mesothelioma ⁷⁴	11.89	VEGFC RPS6 MTOR MAP3K5 JUN FLT4
42	Hippo-Merlin signaling dysregulation ⁷⁴ Show member pathways Hippo signaling regulation pathways ⁷⁴	11.81	MTOR FLT4 EGFR
43	Angiogenesis (CST) ³	11.8	VEGFC PECAM1 FLT4
44	Interferon Pathway ⁶⁴	11.74	RPS6 MTOR MAP3K5 EIF4EBP1
45	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ⁶¹	11.66	MTOR JUN EIF4EBP1
46	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁴ Show member pathways TOB in T-Cell Signaling ⁶⁴	11.57	JUN EGFR EGF
47	Head and neck squamous cell carcinoma ⁷⁴	11.57	RPS6 MTOR EIF4EBP1 EGFR
48	NRP1-triggered signaling pathways in pancreatic cancer ⁷⁴	11.52	PECAM1 EGFR EGF
49	Regulation of Telomerase ⁶¹	11.46	MTOR JUN EGFR EGF
50	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins ²²	11.33	PMAIP1 MAP3K5 JUN

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GO Terms for Pyriform Sinus Cancer

Biological processes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell migration	GO:0030335	9.97	VEGFC PECAM1 FLT4 EGFR EGF
2	ERBB2-EGFR signaling pathway	GO:0038134	9.71	EGFR EGF
3	axon ensheathment	GO:0008366	9.67	POU3F1 CLDN11
4	positive regulation of phosphorylation	GO:0042327	9.65	FLT4 EGFR EGF
5	TOR signaling	GO:0031929	9.63	EIF4EBP1 MTOR RPS6
6	positive regulation of endothelial cell proliferation	GO:0001938	9.56	VEGFC JUN FLT4 EGF
7	positive regulation of protein phosphorylation	GO:0001934	9.32	VEGFC PECAM1 MTOR MAP3K5 FLT4 EGFR

Sources

Sources for Pyriform Sinus Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PYR008 MIFTS: 31	Pyriform Sinus Cancer Categories: Cancer diseases, Gastrointestinal diseases	Data Licensing For inquiries, contact: [email protected]
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