MCID: PYR008
MIFTS: 31

Pyriform Sinus Cancer

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Pyriform Sinus Cancer

MalaCards integrated aliases for Pyriform Sinus Cancer:

Name: Pyriform Sinus Cancer 11 14
Malignant Neoplasm of the Pyriform Fossa 11
Malignant Neoplasm of Pyriform Fossa 11
Malignant Tumor of Pyriform Fossa 11

Classifications:



External Ids:

Disease Ontology 11 DOID:9235
ICD9CM 34 148.1
NCIt 49 C3531
SNOMED-CT 68 363401000
ICD10 31 C12
UMLS 71 C0153400

Summaries for Pyriform Sinus Cancer

MalaCards based summary: Pyriform Sinus Cancer, also known as malignant neoplasm of the pyriform fossa, is related to sinus cancer and acquired hemangioma. An important gene associated with Pyriform Sinus Cancer is POU3F1 (POU Class 3 Homeobox 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include lymph node, and related phenotypes are Decreased viability with paclitaxel and Reduced mammosphere formation

Related Diseases for Pyriform Sinus Cancer

Diseases related to Pyriform Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 sinus cancer 10.8
2 acquired hemangioma 10.2 PECAM1 LYVE1
3 intramuscular hemangioma 10.2 PECAM1 LYVE1
4 ovarian angiosarcoma 10.2 SSX2 PECAM1
5 kidney hemangiopericytoma 10.2 SSX2 PECAM1
6 48,xyyy 10.2
7 heart sarcoma 10.2 SSX2 PECAM1
8 epithelioid hemangioendothelioma 10.1 PECAM1 FLT4
9 glottis squamous cell carcinoma 10.1 MAP3K5 EGFR
10 rapidly involuting congenital hemangioma 10.1 PECAM1 FLT4
11 breast angiosarcoma 10.1 PECAM1 FLT4
12 hobnail hemangioma 10.1 PECAM1 FLT4
13 heart leiomyosarcoma 10.1 PECAM1 EGFR
14 childhood angiosarcoma 10.0 PECAM1 FLT4
15 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
16 rhabdomyosarcoma 2 10.0
17 spastic paraplegia, ataxia, and mental retardation 10.0
18 head and neck cancer 10.0
19 larynx cancer 10.0
20 laryngeal benign neoplasm 10.0
21 hypopharynx cancer 10.0
22 49, xxxxy syndrome 10.0
23 ring chromosome 22 10.0
24 supraglottic laryngeal cancer 10.0
25 acute sensory ataxic neuropathy 10.0
26 lymphangiosarcoma 10.0 PECAM1 LYVE1 FLT4
27 capillary lymphangioma 10.0 PECAM1 LYVE1 FLT4
28 pyogenic granuloma 10.0 PECAM1 LYVE1 FLT4
29 urethra transitional cell carcinoma 10.0 FLT4 EGFR
30 congenital lymphedema 10.0 VEGFC FLT4
31 lung carcinoma in situ 10.0 EGFR EGF
32 chylothorax, congenital 10.0 VEGFC FLT4
33 mixed cell adenoma 9.9 EGFR EGF
34 corneal disease 9.9 PECAM1 LYVE1 EGF
35 pulmonary adenocarcinoma in situ 9.9 EGFR EGF
36 cystic lymphangioma 9.9 PECAM1 FLT4
37 familiar ovarian carcinoma 9.9 VEGFC FLT4
38 hereditary lymphedema 9.9 VEGFC LYVE1 FLT4
39 hereditary lymphedema i 9.9 VEGFC LYVE1 FLT4
40 lymphedema-distichiasis syndrome 9.9 VEGFC LYVE1 FLT4
41 elephantiasis 9.9 VEGFC FLT4
42 brain glioblastoma multiforme 9.9 EGFR EGF
43 keratitis, hereditary 9.9 VEGFC PECAM1 LYVE1
44 inflammatory breast carcinoma 9.9 VEGFC LYVE1 EGFR
45 amelogenesis imperfecta, type ig 9.8 JUN EGFR EGF
46 gastroesophageal junction adenocarcinoma 9.8 VEGFC EGFR
47 primary lymphedema 9.8 VEGFC FLT4
48 kidney angiomyolipoma 9.8 RPS6 MTOR EIF4EBP1
49 subependymal glioma 9.8 RPS6 MTOR EIF4EBP1
50 acneiform dermatitis 9.8 MTOR EGFR

Graphical network of the top 20 diseases related to Pyriform Sinus Cancer:



Diseases related to Pyriform Sinus Cancer

Symptoms & Phenotypes for Pyriform Sinus Cancer

GenomeRNAi Phenotypes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 CLDN11 CNDP2 EGF EGFR EIF4EBP1 EYS
2 no effect GR00402-S-2 10.15 CLDN11 CNDP2 EGF EGFR EIF4EBP1 EYS
3 Decreased viability with paclitaxel GR00179-A-1 9.55 EGFR MTOR
4 Decreased viability with paclitaxel GR00179-A-2 9.55 MTOR
5 Decreased viability with paclitaxel GR00179-A-3 9.55 EGFR MTOR
6 Reduced mammosphere formation GR00396-S 9.43 CLDN11 EGFR EIF4EBP1 JUN MTOR RPS6

MGI Mouse Phenotypes related to Pyriform Sinus Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 CLDN11 EGFR EIF4EBP1 FLT4 JUN KCNE1
2 cardiovascular system MP:0005385 9.7 CNDP2 EGFR EIF4EBP1 FLT4 JUN KCNE1
3 immune system MP:0005387 9.4 CNDP2 EGF EGFR FLT4 JUN KCNE1

Drugs & Therapeutics for Pyriform Sinus Cancer

Search Clinical Trials, NIH Clinical Center for Pyriform Sinus Cancer

Genetic Tests for Pyriform Sinus Cancer

Anatomical Context for Pyriform Sinus Cancer

Organs/tissues related to Pyriform Sinus Cancer:

MalaCards : Lymph Node

Publications for Pyriform Sinus Cancer

Articles related to Pyriform Sinus Cancer:

(show top 50) (show all 62)
# Title Authors PMID Year
1
Outcomes of Patients Undergoing Emergency Tracheostomy During COVID 19 Pandemic: Our Experience from a Tertiary Care Centre in North-East India. 62
33686367 2022
2
Lymph node ratio predicts recurrence-free survival and disease-specific survival of patients with pyriform sinus squamous cell carcinoma. 62
36184282 2022
3
Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes. 62
34825265 2022
4
A domain knowledge enhanced yield based deep learning classifier identifies perineural invasion in oral cavity squamous cell carcinoma. 62
36353548 2022
5
Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study. 62
30409296 2018
6
Combined transoral-transhyoid endoscopic approach for hypopharyngeal cancer. 62
29402609 2018
7
Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer. 62
30464497 2018
8
[Surgical management of elderly patients with medial wall pyriform sinus cancer]. 62
29262511 2017
9
Therapeutic Management of Pyriform Sinus Cancer. 62
28072556 2017
10
Transoral robotic surgery for early T classification hypopharyngeal cancer. 62
26559383 2016
11
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. 62
25804347 2015
12
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study. 62
24849707 2014
13
[Treatment of pyriform sinus carcinoma involving the lateral wall]. 62
23886091 2013
14
Fluorodeoxyglucose-induced allergic reaction: a case report. 62
22267446 2013
15
[Musculomucosal flaps of posterior laryngopharynx wall for reconstruction after resection of pyriform sinus cancer]. 62
23700813 2013
16
Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. 62
24244346 2013
17
Necessity of routine ipsilateral hemithyroidectomy during laryngopharyngectomy for pyriform sinus cancer. 62
22382374 2012
18
Free jejunal graft for esophageal reconstruction using end-to-side vascular anastomosis and extended pharyngo-jejunostomy. 62
22440367 2012
19
Laminin-5 immunohistochemical mapping for analysis of local extension in hypopharyngeal cancer: A preliminary report. 62
21871747 2012
20
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options. 62
23107977 2012
21
Preservation of laryngeal functions in surgical treatment of pyriform sinus carcinoma. 62
21133828 2011
22
[Clinical analysis of surgical complications after preoperative concurrent chemoradiotherapy of pyriform sinus cancer]. 62
21426704 2011
23
Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. 62
20582549 2010
24
Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. 62
20619721 2010
25
[Treatment and clinical analysis of laryngeal function preserving surgery in hypopharyngeal carcinoma]. 62
20359116 2009
26
[Applied study of voice function rehabilitation by mucosa tube performed in operation of late laryngocarcinoma.]. 62
20079073 2009
27
Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. 62
19671141 2009
28
[Laryngeal function preserving surgery in hypopharyngeal carcinoma]. 62
19954017 2009
29
Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. 62
18804408 2009
30
[Early detection of recurrent hypopharyngeal cancer after radiotherapy by utilizing narrow-band imaging--report of a case]. 62
18018596 2007
31
[Preservation of laryngeal function in treatment of pyriform sinus carcinoma]. 62
17441428 2007
32
Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. 62
16920307 2006
33
[Surgical treatment on primary lesion of advanced pyriform sinus cancer]. 62
16995308 2006
34
[Comprehensive treatment of advanced pyriform sinus cancer]. 62
16671524 2006
35
[Cervical lymph node metastasis of hypopharyngeal carcinoma]. 62
16408732 2005
36
[Treatment and survival analysis of pyriform sinus cancer]. 62
16270875 2005
37
[Preservation of laryngeal function in surgical treatment of pyriform sinus carcinoma]. 62
15952574 2005
38
Correlation of local outcome after partial laryngectomy with cartilage abnormalities on CT. 62
15760887 2005
39
Conservation laryngeal surgery for selected pyriform sinus cancer. 62
15522562 2004
40
[Hypopharynx reconstruction of defects after operation on advanced pyriform sinus cancer with remaining laryngeal mucosa flap and pectoralis major myocutaneous flap]. 62
15323445 2004
41
[Preservation of laryngeal function in surgery for medial wall pyriform sinus cancer]. 62
12515629 2002
42
[Preservative surgery of medial wall pyriform sinus cancer]. 62
12761989 2001
43
[Laryngeal function-sparing surgery for pyriform sinus cancer]. 62
12768706 2000
44
Larynx preservation surgery in pyriform sinus cancer. 62
11071322 2000
45
Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. 62
9874427 1998
46
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. 62
8656441 1996
47
Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer. 62
8693597 1996
48
Outcome of pyriform sinus cancer: a retrospective institutional review. 62
8544623 1996
49
Prognostic factors for local control in hypopharyngeal cancer treated with radical irradiation. 62
8571184 1996
50
Laryngotracheal flap for reconstruction of hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. 62
7712839 1995

Variations for Pyriform Sinus Cancer

Expression for Pyriform Sinus Cancer

Search GEO for disease gene expression data for Pyriform Sinus Cancer.

Pathways for Pyriform Sinus Cancer

Pathways related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 VEGFC PMAIP1 MTOR MAP3K5 JUN FLT4
2 13.74 VEGFC RPS6 MTOR JUN FLT4 EIF4EBP1
3
Show member pathways
13.42 RPS6 MTOR MAP3K5 JUN EIF4EBP1 EGFR
4
Show member pathways
13.4 EGF EGFR EIF4EBP1 FLT4 JUN MAP3K5
5
Show member pathways
13.33 VEGFC MTOR MAP3K5 FLT4 EIF4EBP1 EGFR
6
Show member pathways
13.25 VEGFC MAP3K5 JUN FLT4 EGFR EGF
7
Show member pathways
13.21 VEGFC MAP3K5 JUN FLT4 EGFR EGF
8
Show member pathways
12.83 PMAIP1 MTOR MAP3K5 JUN EGFR EGF
9
Show member pathways
12.8 RPS6 MTOR MAP3K5 JUN EGFR
10 12.77 VEGFC MTOR FLT4 EGFR EGF
11
Show member pathways
12.63 VEGFC MAP3K5 FLT4 EGFR EGF
12
Show member pathways
12.62 PMAIP1 MTOR JUN EGFR EGF
13
Show member pathways
12.61 VEGFC MAP3K5 JUN EGFR
14
Show member pathways
12.61 MAP3K5 JUN EGFR EGF
15
Show member pathways
12.61 VEGFC RPS6 MTOR FLT4 EIF4EBP1 EGFR
16
Show member pathways
12.58 VEGFC MTOR FLT4 EGFR EGF
17
Show member pathways
12.58 RPS6 MTOR JUN EIF4EBP1 EGFR EGF
18
Show member pathways
12.46 EIF4EBP1 JUN MAP3K5 MTOR
19
Show member pathways
12.44 VEGFC RPS6 MTOR JUN FLT4 EIF4EBP1
20
Show member pathways
12.43 MTOR JUN EGFR EGF
21
Show member pathways
12.37 EGFR FLT4 JUN MTOR
22
Show member pathways
12.37 MTOR JUN FLT4 EGFR EGF
23
Show member pathways
12.36 VEGFC JUN FLT4 EGFR EGF
24 12.34 MAP3K5 JUN EGFR EGF
25
Show member pathways
12.3 VEGFC JUN FLT4 EGFR EGF
26
Show member pathways
12.26 VEGFC MTOR JUN FLT4 EGFR EGF
27 12.22 EGF EGFR JUN VEGFC
28
Show member pathways
12.19 RPS6 MTOR MAP3K5 EIF4EBP1
29
Show member pathways
12.14 RPS6 MTOR FLT4 EIF4EBP1 EGFR
30 12.06 VEGFC FLT4 EGFR EGF
31
Show member pathways
12.05 EGF EGFR EIF4EBP1 MTOR
32
Show member pathways
12.05 EGF EGFR JUN MTOR RPS6
33
Show member pathways
12.02 RPS6 MTOR EIF4EBP1
34 12.02 MTOR FLT4 EIF4EBP1 EGFR
35 12 PMAIP1 JUN EGFR
36
Show member pathways
11.97 MTOR JUN EIF4EBP1
37
Show member pathways
11.97 RPS6 MTOR JUN
38
Show member pathways
11.93 RPS6 MTOR MAP3K5
39
Show member pathways
11.92 JUN EGFR EGF
40 11.9 RPS6 JUN EIF4EBP1 EGFR
41 11.89 VEGFC RPS6 MTOR MAP3K5 JUN FLT4
42
Show member pathways
11.81 MTOR FLT4 EGFR
43 11.8 VEGFC PECAM1 FLT4
44 11.74 RPS6 MTOR MAP3K5 EIF4EBP1
45 11.66 MTOR JUN EIF4EBP1
46
Show member pathways
11.57 JUN EGFR EGF
47 11.57 RPS6 MTOR EIF4EBP1 EGFR
48 11.52 PECAM1 EGFR EGF
49 11.46 MTOR JUN EGFR EGF
50 11.33 PMAIP1 MAP3K5 JUN

GO Terms for Pyriform Sinus Cancer

Biological processes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.97 VEGFC PECAM1 FLT4 EGFR EGF
2 ERBB2-EGFR signaling pathway GO:0038134 9.71 EGFR EGF
3 axon ensheathment GO:0008366 9.67 POU3F1 CLDN11
4 positive regulation of phosphorylation GO:0042327 9.65 FLT4 EGFR EGF
5 TOR signaling GO:0031929 9.63 EIF4EBP1 MTOR RPS6
6 positive regulation of endothelial cell proliferation GO:0001938 9.56 VEGFC JUN FLT4 EGF
7 positive regulation of protein phosphorylation GO:0001934 9.32 VEGFC PECAM1 MTOR MAP3K5 FLT4 EGFR

Sources for Pyriform Sinus Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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