MCID: PYR008
MIFTS: 24

Pyriform Sinus Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Bone diseases

Aliases & Classifications for Pyriform Sinus Cancer

MalaCards integrated aliases for Pyriform Sinus Cancer:

Name: Pyriform Sinus Cancer 12 15
Malignant Neoplasm of the Pyriform Fossa 12
Malignant Neoplasm of Pyriform Fossa 12
Malignant Tumor of Pyriform Fossa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9235
ICD10 33 C12
ICD9CM 35 148.1
NCIt 50 C3531
SNOMED-CT 68 363401000 93978008
UMLS 73 C0153400

Summaries for Pyriform Sinus Cancer

MalaCards based summary : Pyriform Sinus Cancer, also known as malignant neoplasm of the pyriform fossa, is related to sinus cancer and laryngitis. An important gene associated with Pyriform Sinus Cancer is CNDP2 (Carnosine Dipeptidase 2). The drugs motexafin gadolinium and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pyriform Sinus Cancer

Diseases related to Pyriform Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 sinus cancer 10.5
2 laryngitis 10.0
3 laryngotracheitis 9.9
4 supraglottic laryngeal cancer 9.9

Symptoms & Phenotypes for Pyriform Sinus Cancer

GenomeRNAi Phenotypes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.86 WARS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.86 CNDP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.86 CNDP2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.86 CNDP2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.86 WARS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.86 WARS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.86 WARS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.86 CNDP2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.86 WARS CNDP2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.86 CNDP2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.86 WARS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.86 CNDP2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.86 CNDP2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.86 CNDP2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.86 CNDP2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 CNDP2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.53 WARS
18 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.53 WARS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 CNDP2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.53 CNDP2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 CNDP2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.53 CNDP2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.53 CNDP2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.53 CNDP2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.53 WARS
26 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.53 CNDP2 WARS
27 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.53 WARS
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.53 WARS
29 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 WARS
30 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 CNDP2

Drugs & Therapeutics for Pyriform Sinus Cancer

Drugs for Pyriform Sinus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
motexafin gadolinium Investigational Phase 1 156436-89-4 12047567
2 Dermatologic Agents Phase 1
3 Photosensitizing Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection

Search NIH Clinical Center for Pyriform Sinus Cancer

Genetic Tests for Pyriform Sinus Cancer

Anatomical Context for Pyriform Sinus Cancer

MalaCards organs/tissues related to Pyriform Sinus Cancer:

41
Bone

Publications for Pyriform Sinus Cancer

Articles related to Pyriform Sinus Cancer:

(show all 20)
# Title Authors Year
1
Therapeutic Management of Pyriform Sinus Cancer. ( 28072556 )
2017
2
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. ( 25804347 )
2015
3
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study. ( 24849707 )
2014
4
Necessity of routine ipsilateral hemithyroidectomy during laryngopharyngectomy for pyriform sinus cancer. ( 22382374 )
2012
5
Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. ( 20582549 )
2010
6
Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. ( 16920307 )
2006
7
Conservation laryngeal surgery for selected pyriform sinus cancer. ( 15522562 )
2004
8
Larynx preservation surgery in pyriform sinus cancer. ( 11071322 )
2000
9
Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer. ( 8693597 )
1996
10
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. ( 8656441 )
1996
11
Outcome of pyriform sinus cancer: a retrospective institutional review. ( 8544623 )
1996
12
Laryngotracheal flap for reconstruction of hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. ( 7712839 )
1995
13
Reconstruction of the hypopharynx using hemilarynx for localized pyriform sinus cancer. ( 7968173 )
1994
14
Hemipharyngectomy and hemilaryngectomy for pyriform sinus cancer: reconstruction with remaining larynx and hypopharynx and with tracheostomy. ( 8421425 )
1993
15
Discrepancies between clinical and histopathologic diagnoses in T3 pyriform sinus cancer. ( 3796180 )
1987
16
Surgical treatment of pyriform sinus cancer: a retrospective study. ( 6503579 )
1984
17
Differentiation of pyriform sinus cancer from supraglottic laryngeal cancer by computed tomography. ( 7291568 )
1981
18
Combined therapy for pyriform sinus cancer using postoperative irradiation. ( 7208042 )
1980
19
Pyriform sinus cancer: a clinical and laboratory study. ( 1200569 )
1975
20
Partial laryngopharyngectomy and neck dissection for pyriform sinus cancer. Conservation surgery with immediate reconstruction. ( 13730467 )
1960

Variations for Pyriform Sinus Cancer

Expression for Pyriform Sinus Cancer

Search GEO for disease gene expression data for Pyriform Sinus Cancer.

Pathways for Pyriform Sinus Cancer

GO Terms for Pyriform Sinus Cancer

Biological processes related to Pyriform Sinus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 8.96 JUN WARS
2 angiogenesis GO:0001525 8.62 JUN WARS

Sources for Pyriform Sinus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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