MCID: PYR008
MIFTS: 20

Pyriform Sinus Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Pyriform Sinus Cancer

MalaCards integrated aliases for Pyriform Sinus Cancer:

Name: Pyriform Sinus Cancer 12 15
Malignant Neoplasm of the Pyriform Fossa 12
Malignant Neoplasm of Pyriform Fossa 12
Malignant Tumor of Pyriform Fossa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9235
ICD9CM 35 148.1
NCIt 50 C3531
SNOMED-CT 68 93978008
ICD10 33 C12
UMLS 72 C0153400

Summaries for Pyriform Sinus Cancer

MalaCards based summary : Pyriform Sinus Cancer, also known as malignant neoplasm of the pyriform fossa, is related to sinus cancer and multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly. An important gene associated with Pyriform Sinus Cancer is CNDP2 (Carnosine Dipeptidase 2). The drugs Motexafin gadolinium and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node.

Related Diseases for Pyriform Sinus Cancer

Diseases related to Pyriform Sinus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 sinus cancer 10.8
2 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
3 hypopharynx cancer 10.1
4 48,xyyy 10.1
5 supraglottic laryngeal cancer 10.1
6 acute sensory ataxic neuropathy 10.1
7 sarcoma 9.5 SSX2 JUN

Graphical network of the top 20 diseases related to Pyriform Sinus Cancer:



Diseases related to Pyriform Sinus Cancer

Symptoms & Phenotypes for Pyriform Sinus Cancer

Drugs & Therapeutics for Pyriform Sinus Cancer

Drugs for Pyriform Sinus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Motexafin gadolinium Investigational Phase 1 156436-89-4, 246252-06-2 12047567
2 Dermatologic Agents Phase 1
3 Photosensitizing Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Trial of Motexafin Gadolinium and Chemoradiation in Locally Advanced, Squamous Cell Carcinoma of the Head and Neck Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection

Search NIH Clinical Center for Pyriform Sinus Cancer

Genetic Tests for Pyriform Sinus Cancer

Anatomical Context for Pyriform Sinus Cancer

MalaCards organs/tissues related to Pyriform Sinus Cancer:

41
Lymph Node

Publications for Pyriform Sinus Cancer

Articles related to Pyriform Sinus Cancer:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study. 38
30409296 2018
2
Combined transoral-transhyoid endoscopic approach for hypopharyngeal cancer. 38
29402609 2018
3
Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer. 38
30464497 2018
4
[Surgical management of elderly patients with medial wall pyriform sinus cancer]. 38
29262511 2017
5
Therapeutic Management of Pyriform Sinus Cancer. 38
28072556 2017
6
Transoral robotic surgery for early T classification hypopharyngeal cancer. 38
26559383 2016
7
Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. 38
25804347 2015
8
A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by potentiated radiotherapy: a multicenter, retrospective study. 38
24849707 2014
9
[Treatment of pyriform sinus carcinoma involving the lateral wall]. 38
23886091 2013
10
Fluorodeoxyglucose-induced allergic reaction: a case report. 38
22267446 2013
11
[Musculomucosal flaps of posterior laryngopharynx wall for reconstruction after resection of pyriform sinus cancer]. 38
23700813 2013
12
Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. 38
24244346 2013
13
Necessity of routine ipsilateral hemithyroidectomy during laryngopharyngectomy for pyriform sinus cancer. 38
22382374 2012
14
Laminin-5 immunohistochemical mapping for analysis of local extension in hypopharyngeal cancer: A preliminary report. 38
21871747 2012
15
Free jejunal graft for esophageal reconstruction using end-to-side vascular anastomosis and extended pharyngo-jejunostomy. 38
22440367 2012
16
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options. 38
23107977 2012
17
Preservation of laryngeal functions in surgical treatment of pyriform sinus carcinoma. 38
21133828 2011
18
[Clinical analysis of surgical complications after preoperative concurrent chemoradiotherapy of pyriform sinus cancer]. 38
21426704 2011
19
Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. 38
20582549 2010
20
Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. 38
20619721 2010
21
[Treatment and clinical analysis of laryngeal function preserving surgery in hypopharyngeal carcinoma]. 38
20359116 2009
22
[Applied study of voice function rehabilitation by mucosa tube performed in operation of late laryngocarcinoma.]. 38
20079073 2009
23
Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. 38
19671141 2009
24
[Laryngeal function preserving surgery in hypopharyngeal carcinoma]. 38
19954017 2009
25
Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. 38
18804408 2009
26
[Early detection of recurrent hypopharyngeal cancer after radiotherapy by utilizing narrow-band imaging--report of a case]. 38
18018596 2007
27
[Preservation of laryngeal function in treatment of pyriform sinus carcinoma]. 38
17441428 2007
28
Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. 38
16920307 2006
29
[Surgical treatment on primary lesion of advanced pyriform sinus cancer]. 38
16995308 2006
30
[Comprehensive treatment of advanced pyriform sinus cancer]. 38
16671524 2006
31
[Cervical lymph node metastasis of hypopharyngeal carcinoma]. 38
16408732 2005
32
[Treatment and survival analysis of pyriform sinus cancer]. 38
16270875 2005
33
Correlation of local outcome after partial laryngectomy with cartilage abnormalities on CT. 38
15760887 2005
34
[Preservation of laryngeal function in surgical treatment of pyriform sinus carcinoma]. 38
15952574 2005
35
Conservation laryngeal surgery for selected pyriform sinus cancer. 38
15522562 2004
36
[Hypopharynx reconstruction of defects after operation on advanced pyriform sinus cancer with remaining laryngeal mucosa flap and pectoralis major myocutaneous flap]. 38
15323445 2004
37
[Preservation of laryngeal function in surgery for medial wall pyriform sinus cancer]. 38
12515629 2002
38
[Preservative surgery of medial wall pyriform sinus cancer]. 38
12761989 2001
39
[Laryngeal function-sparing surgery for pyriform sinus cancer]. 38
12768706 2000
40
Larynx preservation surgery in pyriform sinus cancer. 38
11071322 2000
41
Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. 38
9874427 1998
42
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. 38
8656441 1996
43
Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer. 38
8693597 1996
44
Prognostic factors for local control in hypopharyngeal cancer treated with radical irradiation. 38
8571184 1996
45
Outcome of pyriform sinus cancer: a retrospective institutional review. 38
8544623 1996
46
Laryngotracheal flap for reconstruction of hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. 38
7712839 1995
47
Reconstruction of the hypopharynx using hemilarynx for localized pyriform sinus cancer. 38
7968173 1994
48
Prevertebral fascia flap in hypopharyngeal reconstruction: a preliminary report. 38
8491322 1993
49
Hemipharyngectomy and hemilaryngectomy for pyriform sinus cancer: reconstruction with remaining larynx and hypopharynx and with tracheostomy. 38
8421425 1993
50
The prognostic significance of lymph node involvement in pyriform sinus and supraglottic cancers. 38
3610702 1987

Variations for Pyriform Sinus Cancer

Expression for Pyriform Sinus Cancer

Search GEO for disease gene expression data for Pyriform Sinus Cancer.

Pathways for Pyriform Sinus Cancer

GO Terms for Pyriform Sinus Cancer

Sources for Pyriform Sinus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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