Aliases & Classifications for Pyromania

MalaCards integrated aliases for Pyromania:

Name: Pyromania 12 15
Firesetting Behavior 12 43 71
Pathological Firesetting 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12402
ICD9CM 34 312.33
MeSH 43 D005391
NCIt 49 C94334
SNOMED-CT 67 248015004
ICD10 32 F63.1
UMLS 71 C0016142

Summaries for Pyromania

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive.

MalaCards based summary : Pyromania, also known as firesetting behavior, is related to personality disorder and kleptomania. An important gene associated with Pyromania is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Parkinson disease and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. Affiliated tissues include brain, skin and temporal lobe, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 Pyromania is an impulse control disorder in which individuals repeatedly fail to resist impulses to... more...

Related Diseases for Pyromania

Diseases related to Pyromania via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.0 MAOA HTR1B DRD2
2 kleptomania 29.8 SLITRK1 RTN4 MAOA DRD2 DNER
3 avoidant personality disorder 29.8 WASF1 MAOA HTR1B
4 alcohol use disorder 29.6 WASF1 HTR1B DRD2
5 mood disorder 29.5 MAOA HTR1B DRD2
6 disease of mental health 29.5 WASF1 RTN4 MAOA DRD2
7 alcohol dependence 29.4 MAOA HTR1B DRD2
8 impulse control disorder 28.8 WASF1 SLITRK1 RTN4 MAOA DRD2 DNER
9 brunner syndrome 11.3
10 body dysmorphic disorder 10.2 SLITRK1 MAOA
11 pedophilia 10.2 RTN4 MAOA
12 paraphilia disorder 10.2 RTN4 MAOA
13 chronic tic disorder 10.2 SLITRK1 DRD2
14 temporal lobe epilepsy 10.1
15 neurotic disorder 10.1
16 obsessive-compulsive personality disorder 10.1 WASF1 SLITRK1
17 barbiturate abuse 10.1 WASF1 MAOA
18 trichotillomania 10.1 SLITRK1 DRD2
19 separation anxiety disorder 10.0 WASF1 RTN4
20 schizoid personality disorder 10.0 WASF1 DRD2
21 dysthymic disorder 10.0 WASF1 MAOA
22 hallucinogen dependence 10.0 WASF1 DRD2
23 intermittent explosive disorder 10.0 SLITRK1 MAOA DRD2
24 cannabis abuse 10.0 WASF1 DRD2
25 heroin dependence 10.0 MAOA DRD2
26 agoraphobia 10.0 WASF1 MAOA
27 gilles de la tourette syndrome 10.0 SLITRK1 MAOA DRD2
28 schizotypal personality disorder 9.9 WASF1 DRD2
29 cannabis dependence 9.9 WASF1 DRD2
30 phobia, specific 9.9 WASF1 RTN4 MAOA
31 psychotic disorder 9.8 MAOA DRD2 CHRNA7
32 phobic disorder 9.8 WASF1 MAOA DRD2
33 social phobia 9.8 WASF1 MAOA DRD2
34 endogenous depression 9.8 WASF1 MAOA
35 tic disorder 9.7 SLITRK1 RTN4 MAOA DRD2
36 chromosome 15q13.3 deletion syndrome 9.7 MTMR10 CHRNA7 ARHGAP11B
37 autosomal dominant nocturnal frontal lobe epilepsy 9.6 MTMR10 CHRNA7 ARHGAP11B
38 epilepsy, myoclonic juvenile 9.6 MTMR10 CHRNA7 ARHGAP11B
39 pervasive developmental disorder 9.6 RTN4 MAOA DRD2 CHRNA7
40 benign epilepsy with centrotemporal spikes 9.6 MTMR10 CHRNA7 ARHGAP11B
41 epilepsy, idiopathic generalized 9.6 MTMR10 CHRNA7 ARHGAP11B
42 borderline personality disorder 9.6 MAOA HTR1B DRD2
43 bulimia nervosa 9.6 MAOA HTR1B DRD2
44 tobacco addiction 9.5 WASF1 MAOA DRD2 CHRNA7
45 oppositional defiant disorder 9.5 WASF1 RTN4 MAOA DRD2
46 anxiety 9.5 MAOA HTR1B DRD2
47 panic disorder 9.5 MAOA HTR1B DRD2
48 specific developmental disorder 9.5 WASF1 RTN4 MAOA DRD2
49 narcolepsy 9.5 MAOA HTR1B DRD2
50 migraine with or without aura 1 9.3 MAOA HTR1B DRD2

Graphical network of the top 20 diseases related to Pyromania:



Diseases related to Pyromania

Symptoms & Phenotypes for Pyromania

MGI Mouse Phenotypes related to Pyromania:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 CHRNA7 DNER DRD2 HTR1B MAOA SLITRK1
2 nervous system MP:0003631 9.17 CHRNA7 DNER DRD2 MAOA RTN4 SLITRK1

Drugs & Therapeutics for Pyromania

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled Study of Naltrexone in Pyromania Withdrawn NCT00467454 Phase 2 Naltrexone;Placebo

Search NIH Clinical Center for Pyromania

Cochrane evidence based reviews: firesetting behavior

Genetic Tests for Pyromania

Anatomical Context for Pyromania

MalaCards organs/tissues related to Pyromania:

40
Brain, Skin, Temporal Lobe

Publications for Pyromania

Articles related to Pyromania:

(show top 50) (show all 104)
# Title Authors PMID Year
1
Neuropsychiatric Aspects of Impulse Control Disorders. 61
32439020 2020
2
Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder. 61
31518848 2019
3
Compulsive sexual behavior disorder in obsessive-compulsive disorder: Prevalence and associated comorbidity. 61
31079471 2019
4
Scales to assess impulsive and compulsive behaviors in Parkinson's disease: Critique and recommendations. 61
31136681 2019
5
A Potential Tension in DSM-5: The General Definition of Mental Disorder versus Some Specific Diagnostic Criteria. 61
29850842 2019
6
Pyromania in court: Legal insanity versus culpability in Western Europe and the Netherlands (1800-1950). 61
29853011 2018
7
Cognitive inflexibility in a young woman with pyromania. 61
29464963 2018
8
[ADH/D and impulsiveness: Prevalence of impulse control disorders and other comorbidities, in 81 adults with attention deficit/hyperactivity disorder (ADH/D)]. 61
26928277 2016
9
Specialist group therapy for psychological factors associated with firesetting: Evidence of a treatment effect from a non-randomized trial with male prisoners. 61
26248329 2015
10
[Arson and pyromania, update 2015]. 61
26591081 2015
11
A look at firesetting, arson, and pyromania. 61
25977346 2015
12
The relationship of DSM-IV pathological gambling to compulsive buying and other possible spectrum disorders: results from the Iowa PG family study. 61
25660732 2015
13
A Practical Guide to Assessing Adult Firesetters' Fire-Specific Treatment Needs Using the Four Factor Fire Scales. 61
26745683 2015
14
Phenomenology and treatment of behavioural addictions. 61
23756285 2013
15
[Gambling brain]. 61
23300105 2013
16
Association between problematic Internet use and impulse control disorders among Iranian university students. 61
22489545 2012
17
Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. 61
21733222 2012
18
Firesetting, arson, pyromania, and the forensic mental health expert. 61
22960918 2012
19
Impulse control disorders in psychiatric inpatients. 61
21546096 2011
20
Pyromania associated with escitalopram in a child. 61
21823913 2011
21
Impulse control disorder comorbidity among patients with bipolar I disorder. 61
21683175 2011
22
Creating a firestorm: a review of children who deliberately light fires. 61
21382537 2011
23
From stack-firing to pyromania: medico-legal concepts of insane arson in British, US and European contexts, c. 1800-1913. Part 2 . 61
21877418 2010
24
From stack-firing to pyromania: medico-legal concepts of insane arson in British, US and European contexts, c. 1800-1913. Part I. 61
21879685 2010
25
The Pictorial Fire Stroop: a measure of processing bias for fire-related stimuli. 61
19707868 2009
26
[Antiepileptic drugs in the control of the impulses disorders]. 61
19927233 2009
27
Volitional disorders: a proposal for DSM-V. 61
18609413 2009
28
Juvenile firesetting in Italy: relationship to aggression, psychopathology, personality, self-efficacy, and school functioning. 61
18301940 2008
29
Solar activity as a possible cause of large forest fires--a case study: analysis of the Portuguese forest fires. 61
18291443 2008
30
Clinical characteristics and psychiatric comorbidity of pyromania. 61
18052565 2007
31
Impulse-control disorders in adolescent psychiatric inpatients: co-occurring disorders and sex differences. 61
17960976 2007
32
[Internet addiction]. 61
17803171 2007
33
Gender differences amongst adult arsonists at psychiatric assessment. 61
17725237 2007
34
The neurobiology of substance and behavioral addictions. 61
17146406 2006
35
Epidemiologic and clinical updates on impulse control disorders: a critical review. 61
16960655 2006
36
Fire interest and antisociality as risk factors in the severity and persistence of juvenile firesetting. 61
16926615 2006
37
Impulsivity and compulsivity in patients with trichotillomania or skin picking compared with patients with obsessive-compulsive disorder. 61
16769303 2006
38
SPECT imaging and treatment of pyromania. 61
16848668 2006
39
Study of impulse control disorders among women presenting nicotine dependence. 61
24941141 2006
40
Looking for pyromania: characteristics of a consecutive sample of Finnish male criminals with histories of recidivist fire-setting between 1973 and 1993. 61
16351734 2005
41
Impulse control disorders in adult psychiatric inpatients. 61
16263865 2005
42
Response of pyromania to biological treatment in a homeless person. 61
18568106 2005
43
[On the psychiatric examination of fire-raisers]. 61
15991730 2005
44
A comparative study of the behavioral, personality, and fire history characteristics of residential and outpatient adolescents (ages 12-17) with firesetting behaviors. 61
16114596 2005
45
[Impulsivity and mental disorders]. 61
15793698 2005
46
[Pathological fire-setting (pyromania)]. 61
14503297 2003
47
Diagnostic of sexual perversions. 61
12834034 2003
48
Commentary: Models and correlates of firesetting behavior. 61
12817843 2003
49
Decreased juvenile arson and firesetting recidivism after implementation of a multidisciplinary prevention program. 61
12169931 2002
50
Exclusions and limitations in children's behavioral health care coverage. 61
11986509 2002

Variations for Pyromania

Expression for Pyromania

Search GEO for disease gene expression data for Pyromania.

Pathways for Pyromania

Pathways related to Pyromania according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 RTN4 MAOA DRD2 CHRNA7
2 10.4 MAOA HTR1B
3
Show member pathways
10.16 MAOA HTR1B DRD2

GO Terms for Pyromania

Cellular components related to Pyromania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.46 WASF1 SLITRK1 RTN4 CHRNA7
2 integral component of presynaptic membrane GO:0099056 8.96 HTR1B DRD2
3 synapse GO:0045202 8.92 WASF1 SLITRK1 DRD2 CHRNA7

Biological processes related to Pyromania according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 excitatory postsynaptic potential GO:0060079 9.51 DRD2 CHRNA7
2 regulation of synaptic vesicle exocytosis GO:2000300 9.49 HTR1B DRD2
3 response to cocaine GO:0042220 9.48 HTR1B DRD2
4 response to nicotine GO:0035094 9.46 DRD2 CHRNA7
5 feeding behavior GO:0007631 9.43 HTR1B DRD2
6 regulation of dopamine secretion GO:0014059 9.4 HTR1B DRD2
7 adult behavior GO:0030534 9.37 SLITRK1 DRD2
8 positive regulation of long-term synaptic potentiation GO:1900273 9.32 DRD2 CHRNA7
9 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.26 HTR1B DRD2
10 G protein-coupled receptor internalization GO:0002031 9.16 HTR1B DRD2
11 drinking behavior GO:0042756 8.96 HTR1B DRD2
12 synapse assembly GO:0007416 8.8 SLITRK1 DRD2 DNER

Sources for Pyromania

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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