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MCID: PYR004
MIFTS: 35

Pyuria

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pyuria

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MalaCards integrated aliases for Pyuria:

Name: Pyuria 12 44 15 73
Pus Cells in Urine 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1439
MeSH 44 D011776
NCIt 50 C119028
SNOMED-CT 68 4800001
UMLS 73 C0034359
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Summaries for Pyuria

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MalaCards based summary : Pyuria, also known as pus cells in urine, is related to chlamydia and acute cystitis, and has symptoms including genitourinary signs and symptoms An important gene associated with Pyuria is CRP (C-Reactive Protein), and among its related pathways/superpathways is Overview of nanoparticle effects. The drugs acetic acid and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, testes and spinal cord.

Wikipedia : 76 Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or... more...

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Related Diseases for Pyuria

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Diseases related to Pyuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 chlamydia 30.5 CRP CXCL8
2 acute cystitis 30.5 ALB BCKDHA CRP CXCL8
3 pyelonephritis 30.2 ALB CRP CXCL8
4 bacterial meningitis 29.7 ALB CRP CXCL8
5 meningitis 29.7 ALB CRP CXCL8
6 urinary system disease 29.6 ALB CRP
7 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.1
8 bacteriuria 10.8
9 kawasaki disease 10.4
10 urethritis 10.2
11 pulmonary aspergilloma 10.2 CRP NUMA1
12 xanthogranulomatous pyelonephritis 10.2 CRP NUMA1
13 gastrointestinal tuberculosis 10.2 ALB CRP
14 abdominal tuberculosis 10.2 ALB CRP
15 decubitus ulcer 10.2 ALB CRP
16 bladder cancer 10.2
17 tuberculous peritonitis 10.2 ALB CRP
18 pericardium disease 10.2 ALB CRP
19 hypersensitivity reaction type iii disease 10.2 ALB CRP
20 peptic ulcer perforation 10.2 ALB CRP
21 analbuminemia 10.2 ALB CRP
22 prediabetes syndrome 10.2 ALB CRP
23 dysentery 10.2 ALB CRP
24 discitis 10.2 CRP MRAP
25 aortitis 10.2 CRP MRAP
26 tenosynovitis 10.2 CRP MRAP
27 pleural disease 10.2 ALB CRP
28 bursitis 10.2 CRP MRAP
29 intermittent claudication 10.2 ALB CRP
30 tendinitis 10.2 CRP MRAP
31 interstitial nephritis 10.1 ALB CRP
32 mesenteric lymphadenitis 10.1 CRP MRAP
33 renal tuberculosis 10.1 CRP MRAP
34 typhoid fever 10.1 ALB CRP
35 rh isoimmunization 10.1 ALB NUMA1
36 coronary stenosis 10.1 ALB CRP
37 bladder disease 10.1 CRP NUMA1
38 palindromic rheumatism 10.1 CRP MRAP
39 homocysteinemia 10.1 ALB CRP
40 cystitis 10.1 CRP CXCL8
41 urethral syndrome 10.1 BCKDHA MRAP
42 pancreas disease 10.1 ALB CRP
43 myasthenic syndrome, congenital, 1a, slow-channel 10.1 CRP CXCL8
44 synovitis 10.1 CRP CXCL8
45 cardiac rupture 10.1 CRP CXCL8
46 orthostatic proteinuria 10.1 ALB MN1
47 nutritional deficiency disease 10.1 ALB CRP
48 systemic lupus erythematosus 10.1
49 spinal cord injury 10.1
50 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Pyuria:



Diseases related to Pyuria
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Symptoms & Phenotypes for Pyuria

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UMLS symptoms related to Pyuria:


genitourinary signs and symptoms
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Drugs & Therapeutics for Pyuria

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Drugs for Pyuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
acetic acid Approved Phase 4 64-19-7 176
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Fosfomycin Approved Phase 4 23155-02-4 446987
5
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
6
Sulfamethoxazole Approved Phase 4 723-46-6 5329
7
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
8
Retinol acetate Phase 4 127-47-9 10245972
9 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3
10 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
11 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
13 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
14 Clavulanic Acids Phase 4
15 Antitubercular Agents Phase 4,Phase 2,Phase 3
16 Anti-Infective Agents, Urinary Phase 4
17 Renal Agents Phase 4
18 Cranberry Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable
19
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
20
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
21
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
22
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
23
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
24
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
25
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
26
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
27 Octenidine Investigational Phase 2, Phase 3 71251-02-0
28
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
29 Antiprotozoal Agents Phase 3
30 Antioxidants Phase 3
31 Antiparasitic Agents Phase 3
32 Anthocyanidin Phase 3
33
Procyanidin Phase 3 4852-22-6 147299
34 Protective Agents Phase 3
35 Proanthocyanidin Phase 3
36 Immunologic Factors Phase 2, Phase 3,Not Applicable
37 Antirheumatic Agents Phase 2, Phase 3
38 Antineoplastic Agents, Hormonal Phase 2, Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
40 Prednisolone acetate Phase 2, Phase 3
41 Immunosuppressive Agents Phase 2, Phase 3
42 Methylprednisolone acetate Phase 2, Phase 3
43 Hormone Antagonists Phase 2, Phase 3
44 Anti-Inflammatory Agents Phase 2, Phase 3
45 Hormones Phase 2, Phase 3
46 glucocorticoids Phase 2, Phase 3
47 Cephalosporins Phase 3
48
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
49
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
50 Dermatologic Agents Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Bladder Lavage as Decontamination Method for Asymptomatic Bacteriuria With Uropathogens in Catheterized Patients Unknown status NCT01772875 Phase 4
2 Safety and Efficacy of a Weekly Oral Cyclic Antibiotic Programme in the Prevention of Urinary Tract Infection on Neurological Bladder Completed NCT01388413 Phase 4 Weekly Oral Cyclic Antibiotic programme
3 Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women Active, not recruiting NCT01966653 Phase 4 nitrofurantoin;fosfomycin
4 Antiseptic-coated Intermittent Urinary Catheter Unknown status NCT02697162 Phase 2, Phase 3 Octenidine chloride
5 A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents Completed NCT01691430 Phase 3
6 Effect of Active vs. Passive Voiding Trials on Time to Discharge, Urinary Tract Infection, and Urinary Retention Completed NCT02886143 Phase 3
7 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Terminated NCT00430677 Phase 2, Phase 3 Corticosteroids (prednisone or prednisolone);Abatacept;Abatacept;Mycophenolate mofetil (MMF);Abatacept
8 An Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections Terminated NCT02302092 Phase 3 Flomoxef;Cefepime
9 Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
10 Multifaceted Treatment of Catheter-related Urinary Tract Infection Completed NCT00732238 Phase 2
11 Pharmacokinetic Study of Oral Gepotidacin (GSK2140944) in Subjects With Uncomplicated Urinary Tract Infection (Acute Cystitis) Recruiting NCT03568942 Phase 1, Phase 2 Gepotidacin
12 Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair & Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
13 The Effect of Intravenous Lipids on Lung Function in Acute Respiratory Distress Syndrome (ARDS) Terminated NCT01096771 Phase 2 ClinOleic 20%;Intralipid 20%
14 Dosing Study of Cranberry Capsules for the Prevention of Bacteriuria in Nursing Home Residents Completed NCT01033383 Phase 1
15 Colonizing Neurogenic Bladders With Benign Flora Completed NCT00371631 Phase 1
16 A Study of NKTR-358 in Participants With Systemic Lupus Erythematosis (SLE) Recruiting NCT03556007 Phase 1 NKTR-358;Placebo
17 Impact of Postoperative Pyuria on Treatment Outcomes After PVP Unknown status NCT02241902
18 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
19 Assessment of UTI Symptoms and Quality of Life According to Antibiotics Treatment in Acute Uncomplicated Cystitis Completed NCT01631955 Ciprobay
20 Effects of a Cranberry Beverage on Women With Recent History of Urinary Tract Infections Completed NCT01776021 Not Applicable
21 Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury Completed NCT01601041
22 Suprapubic Versus Transurethral Catheterization After Rectal Resection With Low Anastomosis for Cancer in Males Recruiting NCT02922647 Not Applicable
23 Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury Recruiting NCT02731027
24 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)? Recruiting NCT03664908 Not Applicable
25 Treatment of Calculous Pyonephrosis With 0.5% Iodophors for I-stage PCNL Not yet recruiting NCT03805542 Not Applicable
26 Comparison of Microtrauma in Urethra After Usage of Different Catheters Terminated NCT01600443 Not Applicable
27 A Trial for the Safety and Effectiveness of a Novel Antimicrobial-Coated Foley Catheter for Reduction of CAUTI. Terminated NCT01681511 Not Applicable

Search NIH Clinical Center for Pyuria

Cochrane evidence based reviews: pyuria

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Genetic Tests for Pyuria

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Anatomical Context for Pyuria

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MalaCards organs/tissues related to Pyuria:

41
Neutrophil, Testes, Spinal Cord, Prostate, Bone, Kidney, Liver
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Publications for Pyuria

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Articles related to Pyuria:

(show top 50) (show all 312)
# Title Authors Year
1
Acute Bilateral Eyelid Edema in a 3-Year-Old Girl With Pyuria. ( 29049456 )
2018
2
A blinded observational cohort study of the microbiological ecology associated with pyuria and overactive bladder symptoms. ( 29455238 )
2018
3
Interpretation of pyuria in children with urinary tract infection. ( 29143990 )
2018
4
<i>Actinotignum schaalii</i> Infection: A Clandestine Cause of Sterile Pyuria? ( 29450211 )
2018
5
Uropathogens and Pyuria in Children With Neurogenic Bladders. ( 29618582 )
2018
6
High Prevalence of Sterile Pyuria in the Setting of Sexually Transmitted Infection in Women Presenting to an Emergency Department. ( 29560055 )
2018
7
Differentiating Kawasaki disease from urinary tract infection in febrile children with pyuria and C-reactive protein elevation. ( 30454066 )
2018
8
Cranberry Capsules for Bacteriuria Plus Pyuria in Nursing Home Residents. ( 28291883 )
2017
9
Cranberry Capsules Don't Prevent Bacteriuria Plus Pyuria in Older Women. ( 28230697 )
2017
10
Results of Real-time Multiplex Polymerase Chain Reaction Assay in Renal Transplant Recipients With Sterile Pyuria. ( 28735999 )
2017
11
Does pyuria always suggest urinary tract infection with common microorganisms? Questions. ( 28721513 )
2017
12
Cranberry Capsules do not Appear to Reduce Bacteriuria and Pyuria in Elderly Women Residing in Nursing Homes. ( 28433645 )
2017
13
Cranberry Capsules for bacteriuria Plus Pyuria in Nursing Home Residents-Reply. ( 28291888 )
2017
14
Cranberry Capsules for Bacteriuria Plus Pyuria in Nursing Home Residents. ( 28291884 )
2017
15
Clinically significant bacteria/pyuria-the author responds. ( 28760381 )
2017
16
Lower urinary tract symptoms that predict microscopic pyuria. ( 28971220 )
2017
17
Does pyuria always suggest urinary tract infection with common microorganisms? Answers. ( 28721514 )
2017
18
Preoperative Pyuria Is a Poor Prognostic Factor in Patients With Urothelial Carcinoma of the Upper Urinary Tract After Surgery. ( 28110834 )
2017
19
Asymptomatic pyuria in pregnant women during the first trimester is associated with an increased risk of adverse obstetrical outcomes. ( 28420507 )
2017
20
Treatment of ED patients with bacteriuria/pyuria of clinically undetermined significance. ( 28736093 )
2017
21
Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy. ( 29102949 )
2017
22
Urine concentration should be taken into account when interpreting pyuria in infants. ( 28526711 )
2017
23
A case of sterile pyuria caused by Chlamydia trachomatis and Mycoplasma hominis: A diagnostic challenge. ( 29063893 )
2017
24
Sterile pyuria: a practical management guide. ( 26917663 )
2016
25
Bacteriuria/Pyuria of Clinically Undetermined Significance (BPCUS): Common, but Currently Nameless. ( 28011317 )
2016
26
Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy. ( 27238381 )
2016
27
A Case of Distal Vaginal Agenesis Presenting with Recurrent Urinary Tract Infection and Pyuria in A Prepubertal Girl. ( 27555476 )
2016
28
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. ( 27787564 )
2016
29
Urinary mycobacterium avium presenting as sterile pyuria. ( 27790302 )
2016
30
Prevalence and prognostic influence of bacterial pyuria in elderly patients with pneumonia: A retrospective study. ( 27301543 )
2016
31
The Diagnosis of UTI: Concentrating on Pyuria. ( 27940802 )
2016
32
Efficacy of Cranberry in Preventing Recurrent Urinary Tract Infections: Have We Learned Anything New? Commentary on: Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. ( 28024965 )
2016
33
Pyuria and Urine Cultures in Patients with Acute Renal Colic. ( 27480349 )
2016
34
Altered urothelial ATP signalling in major subset of human overactive bladder patients with pyuria. ( 27358056 )
2016
35
Urine Concentration and Pyuria for Identifying UTI in Infants. ( 27940788 )
2016
36
Association Between Uropathogen and Pyuria. ( 27328921 )
2016
37
Can absence of pyuria exclude UTI in febrile infants?: About 2011 AAP guidelines. ( 26607772 )
2015
38
Pyuria in patients with Kawasaki disease. ( 26015877 )
2015
39
Sterile pyuria. ( 26061855 )
2015
40
Usefulness of Nonenhanced Computed Tomography for Diagnosing Urolithiasis without Pyuria in the Emergency Department. ( 26421303 )
2015
41
Sterile pyuria. ( 26061856 )
2015
42
Sterile pyuria. ( 25760357 )
2015
43
Procalcitonin and pyuria-based algorithm reduces antibiotic use in urinary tract infections: a randomized controlled trial. ( 25934044 )
2015
44
Editorial Comment to Prognostic value of preoperative pyuria in patients with non-muscle-invasive bladder cancer. ( 25941035 )
2015
45
Short communication: Relationship between urinary neutrophil gelatinase-associated lipocalin and noninfectious pyuria in dogs. ( 25960592 )
2015
46
Sterile pyuria. ( 26061857 )
2015
47
A 53-year-old man with dysuria, pyuria and genital ulcers. ( 25989159 )
2015
48
Pyuria predicts poor prognosis in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-GuAcrin. ( 26623061 )
2015
49
Sterile pyuria: a forgotten entity. ( 26425144 )
2015
50
Isolated hematuria and sterile pyuria may indicate systemic lupus erythematosus activity. ( 25593226 )
2015
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Variations for Pyuria

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Expression for Pyuria

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Search GEO for disease gene expression data for Pyuria.
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Pathways for Pyuria

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Pathways related to Pyuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Overview of nanoparticle effects 1
9.9 CRP CXCL8
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GO Terms for Pyuria

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Sources for Pyuria

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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