Aliases & Classifications for Pyuria

MalaCards integrated aliases for Pyuria:

Name: Pyuria 12 44 15 70
Pus Cells in Urine 12


External Ids:

Disease Ontology 12 DOID:1439
MeSH 44 D011776
NCIt 50 C119028
SNOMED-CT 67 4800001
ICD10 32 R82.81
UMLS 70 C0034359

Summaries for Pyuria

MalaCards based summary : Pyuria, also known as pus cells in urine, is related to urinary tract infection and bacteriuria, and has symptoms including genitourinary signs and symptoms An important gene associated with Pyuria is CRP (C-Reactive Protein), and among its related pathways/superpathways are Folate Metabolism and Pertussis. The drug Cranberry has been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and neutrophil.

Wikipedia : 73 Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or... more...

Related Diseases for Pyuria

Diseases related to Pyuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 555)
# Related Disease Score Top Affiliating Genes
1 urinary tract infection 31.6 LCN2 CRP
2 bacteriuria 31.1 IL6 CXCL8 CRP ALB
3 chlamydia 30.5 IL6 CXCL8 CRP
4 kawasaki disease 30.4 ITPKC IL6 GPT CRP ALB
5 renal tuberculosis 30.2 CRP B2M
6 tuberculous epididymitis 30.2 KLK3 CRP
7 urethritis 30.2 KLK3 IL6 CXCL8 CRP
8 chronic pyelonephritis 30.1 CRP B2M ALB
9 neurogenic bladder 30.1 UPK3A KLK3 CRP ALB
10 pyelonephritis 30.1 LCN2 IL6 GPT CXCL8 CRP ALB
11 protein-energy malnutrition 30.0 IL6 GPT ALB
12 gastroenteritis 29.8 IL6 CXCL8 CRP ALB
13 constipation 29.8 IL6 GPT CRP ALB
14 schistosomiasis 29.7 GPT F2 ALB
15 cystitis 29.7 UPK3A IL6 CXCL8 CRP
16 prostatitis 29.7 KLK3 IL6 CXCL8
17 glomerulonephritis 29.7 PRTN3 LCN2 C3 B2M ALB
18 pneumonia 29.6 IL6 CXCL8 CRP ALB
19 bacterial infectious disease 29.6 LCN2 IL6 CXCL8 CRP
20 acute pyelonephritis 29.6 LCN2 IL6 GPT CXCL8 CRP ALB
21 chronic kidney disease 29.6 LCN2 IL6 HAVCR1 CRP B2M ALB
22 vasculitis 29.6 PRTN3 LCN2 IL6 CRP C3
23 microvascular complications of diabetes 1 29.6 IL6 CXCL8 ALB
24 vesicoureteral reflux 1 29.5 UPK3A LCN2 CXCL8 CRP B2M ALB
25 diarrhea 29.5 IL6 GPT CXCL8 C3 ALB
26 end stage renal disease 29.5 IL6 HAVCR1 CRP C3 B2M ALB
27 neutropenia 29.4 IL6 GPT CXCL8 CRP ALB
28 bacterial meningitis 29.3 IL6 CXCL8 CRP C3 ALB
29 meningitis 29.3 IL6 CXCL8 CRP C3 ALB
30 urinary tract obstruction 29.3 UPK3A LCN2 KLK3 HAVCR1 CRP B2M
31 kidney disease 29.3 PRTN3 LCN2 IL6 CRP C3 B2M
32 nephrotic syndrome 29.0 IL6 F2 CRP C3 B2M ALB
33 acute cystitis 28.9 UPK3A LCN2 KLK3 IL6 HAVCR1 GPT
34 acute kidney failure 28.8 PRTN3 LCN2 HAVCR1 GPT F2 B2M
35 systemic lupus erythematosus 28.1 PRTN3 LCN2 IL6 HAVCR1 F2 CXCL8
36 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 10.9
37 chronic duodenal ileus 10.4 CRP ALB
38 dipetalonemiasis 10.4 GPT ALB
39 heterophyiasis 10.4 GPT ALB
40 afferent loop syndrome 10.4 GPT ALB
41 uvulitis 10.4 GPT CRP
42 peptic ulcer perforation 10.4 CRP ALB
43 ankylosing spondylitis 3 10.4 CRP ALB
44 gummatous syphilis 10.4 GPT CRP
45 tuberculous peritonitis 10.4 CRP ALB
46 viral laryngitis 10.4 GPT CRP
47 glossopharyngeal nerve paralysis 10.4 KLK3 CRP
48 chronic intestinal vascular insufficiency 10.4 CRP ALB
49 meningovascular neurosyphilis 10.4 CRP ALB
50 orthostatic proteinuria 10.4 B2M ALB

Graphical network of the top 20 diseases related to Pyuria:

Diseases related to Pyuria

Symptoms & Phenotypes for Pyuria

UMLS symptoms related to Pyuria:

genitourinary signs and symptoms

Drugs & Therapeutics for Pyuria

Drugs for Pyuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cranberry Approved, Investigational Phase 2

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
2 Does Postoperative Pyuria Influence Treatment Outcomes After Photoselective Vaporization of the Prostate (PVP)?: A Short-term Serial Follow-up Study Unknown status NCT02241902
3 Kinetics of Procalcitonin, C-reactive Protein and Pyuria in Uncomplicated Pyelonephritis in Women: A Pilot Study Completed NCT00805181

Search NIH Clinical Center for Pyuria

Cochrane evidence based reviews: pyuria

Genetic Tests for Pyuria

Anatomical Context for Pyuria

MalaCards organs/tissues related to Pyuria:

Prostate, Spinal Cord, Neutrophil, Lymph Node, Colon, Kidney, Myeloid

Publications for Pyuria

Articles related to Pyuria:

(show top 50) (show all 1866)
# Title Authors PMID Year
Urinary calprotectin, NGAL, and KIM-1 in the differentiation of primarily inflammatory vs. non-inflammatory stable chronic kidney diseases. 61
33663323 2021
Risk factors of febrile urinary tract infections following retrograde intrarenal surgery for renal stones. 61
33787599 2021
Antimicrobial Prophylaxis for Postoperative Urinary Tract Infections in Transurethral Resection of Bladder Tumors: A Systematic Review and Meta-Analysis. 61
33284673 2021
Recurrent UTIs and cystitis symptoms in women. 61
33786541 2021
Hemolysis due to Alpha-Hemolytic Enterococcus Urinary Infection: A Rare Cause of Early and Severe Unconjugated Hyperbilirubinemia in a Neonate. 61
33585066 2021
A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome. 61
33740940 2021
Evaluation of the detection ability of uropathogen morphology and vaginal contamination by the Atellica UAS800 automated urine microscopy analyzer and its effectiveness. 61
33426721 2021
Risk Factors for Urosepsis After Ureteroscopy for Stone Disease: A Systematic Review with Meta-Analysis. 61
33544019 2021
High dose versus low dose standardized cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection in healthy women: a double-blind randomized controlled trial. 61
33757474 2021
Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study. 61
33596989 2021
Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children. 61
33514634 2021
Severe Metabolic Acidosis and Hyperammonemia Induced by the Concomitant Use of Acetazolamide and Aspirin in a Patient With Impaired Renal Function. 61
33608163 2021
Clinical Predictive Value of the Urine Leukocyte Esterase Test Positivity in the Childhood. 61
33548092 2021
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study. 61
33602159 2021
Antibiotic prescribing for adult bacteriuria and pyuria in community hospital emergency departments. 61
33326910 2021
Prevalence of, and factors associated with, positive urine cultures in hyperthyroid cats presenting for radioiodine therapy. 61
32478636 2021
Conditional reflex to urine culture: Evaluation of a diagnostic stewardship intervention within the Veterans' Affairs and Centers for Disease Control and Prevention Practice-Based Research Network. 61
32838829 2021
Antimicrobial Prophylaxis in Transurethral Resection of the Prostate: Results of a Randomized Trial. 61
33560163 2021
Risk factors for urinary bacterial growth in dogs with congenital portosystemic shunts: 66 cases (1997-2019). 61
33491792 2021
Urine abnormalities predict acute kidney injury in COVID-19 patients: An analysis of 110 cases in Chennai, South India. 61
33383438 2021
Pyuria without Casts and Bilateral Kidney Enlargement Are Probable Hallmarks of Severe Acute Kidney Injury Induced by Acute Pyelonephritis: A Case Report and Literature Review. 61
32893233 2021
A case of Pearsonema eggs in the urine sediment of a cat in Trinidad. 61
33308735 2020
Recovery of Chlamydia trachomatis and other pathogens in urine from men with sterile pyuria attended in an emergency department. 61
32402474 2020
Glycosuria and Acute Kidney Injury: A Rare Presentation of Acute Interstitial Nephritis. 61
33319204 2020
Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group. 61
33155086 2020
Non-diabetic glycosuria as a diagnostic clue for acute tubulointerstitial nephritis in patients with azotemia. 61
32985319 2020
Evaluation of urinalysis and urine culture in children with first-time urinary tract infection. 61
33263517 2020
A novel screening method for pediatric urinary tract infection using ordinary diapers. 61
33168907 2020
Pyuria, urinary tract infection and renal outcome in patients with chronic kidney disease stage 3-5. 61
33173137 2020
Urinary CD80 Discriminates Among Glomerular Disease Types and Reflects Disease Activity. 61
33163723 2020
A Case of Left Duplex Kidney with Hydronephrosis Mimicking a Left Renal Cyst in a 29-Year-Old Woman. 61
33221811 2020
Relationship between post-void residual urine volume, preoperative pyuria and intravesical recurrence after transurethral resection of bladder carcinoma. 61
32875619 2020
Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder. 61
33162487 2020
Editorial Comment from Dr Yoshida and Dr Matsuda to Relationship between post-void residual urine volume, preoperative pyuria and intravesical recurrence after transurethral resection of bladder carcinoma. 61
32914469 2020
Editorial Comment from Dr Kojima to Relationship between post-void residual urine volume, preoperative pyuria and intravesical recurrence after transurethral resection of bladder carcinoma. 61
32990342 2020
Is Piperacillin-Tazobactam Effective for the Treatment of Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing Organisms? 61
31859352 2020
[Uncoupling protein 2 overexpression alleviates sepsis-induced myocardial injury via inhibiting reactive oxygen species production and inflammation]. 61
33463495 2020
Hyperammonemia syndrome due to Ureaplasma urealyticum in a kidney transplant recipient: A case of disseminated disease from a fluoroquinolone-resistant isolate. 61
32416005 2020
Clinical manifestations of Kawasaki disease in different age groups: retrospective data from Southwest China. 61
32367406 2020
Incidence of urinary tract infection following initiation of intermittent catheterization among patients with recent spinal cord injury in Germany and the Netherlands. 61
33054606 2020
Perinephric abscess in a renal transplant recipient due to Mycoplasma hominis: Case report and review of the literature. 61
32378787 2020
An adolescent girl with obstructive uropathy requiring nephro-ureterectomy was subsequently diagnosed with renal tuberculosis: case report. 61
32990186 2020
Gene polymorphisms and serum levels of sVEGFR-1 in patients with systemic lupus erythematosus. 61
32929141 2020
Urinary Tract Infections in Young Children and Infants: Common Questions and Answers. 61
32866365 2020
Protocolized Urine Sampling is Associated with Reduced Catheter-Associated Urinary Tract Infections: A Pre- and Post-intervention Study. 61
32776142 2020
Acute severe malnutrition treatment outcomes in children ages 6-59 months admitted to Singa Hospital, Sudan. 61
32484862 2020
Reconsidering asymptomatic bacteriuria and contamination as causes of bacteriuria without pyuria. 61
32448482 2020
[A Case of Panperitonitis Caused by Spontaneous Bladder Rupture]. 61
32723979 2020
Evaluation of Matrix Assisted Laser Desorption Ionisation-Time of Flight Mass Spectrometry in Direct Identification of Bacteriuria from Urine samples. 61
33589179 2020
Evaluation of matrix assisted laser desorption ionisation-time of flight mass spectrometry in direct identification of bacteriuria from urine samples. 61
33154238 2020

Variations for Pyuria

Expression for Pyuria

Search GEO for disease gene expression data for Pyuria.

Pathways for Pyuria

Pathways related to Pyuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.79 IL6 F2 CRP ALB
2 11.31 IL6 CXCL8 C3
3 10.89 IL6 CXCL8 C3
4 10.08 IL6 CXCL8 CRP

GO Terms for Pyuria

Cellular components related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 PRTN3 LCN2 KLK3 IL6 F2 CXCL8
2 endoplasmic reticulum lumen GO:0005788 9.65 IL6 F2 C3 B2M ALB
3 extracellular exosome GO:0070062 9.65 UPK3A PRTN3 NUMA1 LCN2 KLK3 GPT
4 extracellular space GO:0005615 9.36 PRTN3 LCN2 KLK3 IL6 GPT F2

Biological processes related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.62 PRTN3 LCN2 IL6 CXCL8
2 response to molecule of bacterial origin GO:0002237 9.26 CXCL8 B2M
3 negative regulation of lipid storage GO:0010888 9.16 IL6 CRP
4 acute-phase response GO:0006953 9.13 IL6 F2 CRP
5 cellular protein metabolic process GO:0044267 9.1 KLK3 IL6 F2 C3 B2M ALB

Molecular functions related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Pyuria

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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