MCID: PYR004
MIFTS: 35

Pyuria

Categories: Nephrological diseases
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Aliases & Classifications for Pyuria

MalaCards integrated aliases for Pyuria:

Name: Pyuria 11 43 14 71 75
Pus Cells in Urine 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1439
MeSH 43 D011776
NCIt 49 C119028
SNOMED-CT 68 4800001
UMLS 71 C0034359

Summaries for Pyuria

MalaCards based summary: Pyuria, also known as pus cells in urine, is related to bacteriuria and kawasaki disease, and has symptoms including genitourinary signs and symptoms An important gene associated with Pyuria is CRP (C-Reactive Protein), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Extrafollicular B cell activation by SARS-CoV-2. The drug Cranberry has been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and kidney.

Wikipedia: 75 Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or... more...

Related Diseases for Pyuria

Diseases related to Pyuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 668)
# Related Disease Score Top Affiliating Genes
1 bacteriuria 31.5 IL6 CRP ALB
2 kawasaki disease 30.7 ITPKC GPT CRP
3 pyelonephritis 30.6 LCN2 IL6 GPT CRP ALB
4 urethritis 30.5 KLK3 IL6 CRP ALB
5 acute pyelonephritis 30.2 LCN2 IL6 HAVCR1 CRP ALB
6 gastroenteritis 30.2 IL6 CRP ALB
7 miliary tuberculosis 30.1 GPT CRP ALB
8 urogenital tuberculosis 30.1 KLK3 CRP ALB
9 diabetes mellitus, ketosis-prone 30.1 GPT CRP ALB
10 urolithiasis 30.1 IL6 F2 ALB
11 renal tuberculosis 30.1 CRP B2M ALB
12 chronic pyelonephritis 30.1 CRP B2M ALB
13 neurogenic bladder 30.0 UPK3A KLK3 CRP ALB
14 protein-energy malnutrition 30.0 IL6 GPT ALB
15 cystitis 30.0 UPK3A IL6 CRP
16 chronic kidney disease 30.0 LCN2 IL6 CRP B2M ALB
17 autosomal dominant polycystic kidney disease 29.9 LCN2 IL6 HAVCR1 CRP ALB
18 vasculitis 29.9 PRTN3 LCN2 IL6 CRP C3
19 prostatitis 29.9 KLK3 IL6 C3
20 pneumonia 29.9 IL6 GPT CRP ALB
21 meningitis 29.9 IL6 CRP C3 ALB
22 schistosomiasis 29.9 GPT F2 CRP ALB
23 tuberculous epididymitis 29.8 UPK3A KLK3 CRP
24 acquired immunodeficiency syndrome 29.8 IL6 CRP B2M ALB
25 neutropenia 29.8 IL6 GPT CRP ALB
26 vesicoureteral reflux 29.7 UPK3A LCN2 HAVCR1 CRP B2M ALB
27 cerebrovascular disease 29.7 IL6 F2 CRP ALB
28 kidney disease 29.4 PRTN3 LCN2 IL6 F2 CRP B2M
29 glomerulonephritis 29.4 PRTN3 LCN2 IL6 CRP C3 B2M
30 systemic lupus erythematosus 29.3 PRTN3 LCN2 IL6 F2 CRP C3
31 urinary tract obstruction 29.2 UPK3A LCN2 KLK3 IL6 HAVCR1 CRP
32 nephrotic syndrome 29.2 LCN2 IL6 F2 CRP C3 B2M
33 prostatic hypertrophy 29.1 KLK3 CRP ATP4A ATP12A ALB
34 urinary tract infection 29.0 UPK3A LCN2 KLK3 IL6 HAVCR1 GPT
35 acute kidney failure 28.9 PRTN3 LCN2 IL6 HAVCR1 GPT F2
36 hydronephrosis 28.8 UPK3A LCN2 KLK3 IL6 HAVCR1 CRP
37 nutritional deficiency disease 28.8 IL6 F2 CRP ATP4A ATP12A ALB
38 deficiency anemia 28.1 PRTN3 IL6 GPT F2 CRP B2M
39 intestinal tuberculosis 10.4 CRP ALB
40 dipetalonemiasis 10.4 GPT ALB
41 ankylosing spondylitis 3 10.4 CRP ALB
42 spontaneous tension pneumothorax 10.4 GPT CRP
43 nutmeg liver 10.4 GPT ALB
44 acute vascular insufficiency of intestine 10.4 CRP ALB
45 type 1 diabetes mellitus 19 10.4 LCN2 HAVCR1
46 tuberculous peritonitis 10.4 CRP ALB
47 ludwig's angina 10.4 CRP C3
48 heterophyiasis 10.4 GPT ALB
49 viral laryngitis 10.3 GPT CRP
50 ventricular tachycardia, catecholaminergic polymorphic, 4 10.3 LCN2 HAVCR1

Graphical network of the top 20 diseases related to Pyuria:



Diseases related to Pyuria

Symptoms & Phenotypes for Pyuria

UMLS symptoms related to Pyuria:


genitourinary signs and symptoms

Drugs & Therapeutics for Pyuria

Drugs for Pyuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cranberry Approved, Investigational Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
2 Does Postoperative Pyuria Influence Treatment Outcomes After Photoselective Vaporization of the Prostate (PVP)?: A Short-term Serial Follow-up Study Unknown status NCT02241902
3 Kinetics of Procalcitonin, C-reactive Protein and Pyuria in Uncomplicated Pyelonephritis in Women: A Pilot Study Completed NCT00805181
4 The Frequency of Leukocytes and Nitrites in the Urine of Healthy Adults Completed NCT04055675

Search NIH Clinical Center for Pyuria

Cochrane evidence based reviews: pyuria

Genetic Tests for Pyuria

Anatomical Context for Pyuria

Organs/tissues related to Pyuria:

MalaCards : Prostate, Spinal Cord, Kidney, Lymph Node, Neutrophil, Bone Marrow, Colon

Publications for Pyuria

Articles related to Pyuria:

(show top 50) (show all 1975)
# Title Authors PMID Year
1
Autoantibodies in lupus nephritis useful in distinguishing proliferative nephritis from membranous nephritis. 62
36469011 2022
2
Diagnostic test accuracy of dipstick urinalysis for diagnosing urinary tract infection in febrile infants attending the emergency department. 62
36002228 2022
3
The Diagnostic Accuracy Of Procalcitonin for Urinary Tract Infection in Hospitalized Older Adults: a Prospective Study. 62
34997392 2022
4
The influence of repeated flares in response to therapy and prognosis in lupus nephritis. 62
36318456 2022
5
Patterns of renal toxicity from the combination of pemetrexed and pembrolizumab for advanced nonsquamous non-small-cell lung cancer (NSCLC): A single-center experience. 62
36356493 2022
6
A nomogram for predicting the development of serious bacterial infections in febrile term neonates: A single medical center experience in Southern Taiwan. 62
36008242 2022
7
Man With Fever and Pyuria. 62
36153059 2022
8
Urine bacterial culture growth and association with urine sedimentation and clinical findings in cats with acute kidney injury. 62
35748789 2022
9
Leukocyte Esterase and Nitrite Urine Reagent Strip Utility Under Altered Assay Conditions in Dogs. 62
36049239 2022
10
Pyelonephritis of an ectopic right kidney pretending as acute appendicitis: An unusual case. 62
35985113 2022
11
Pyuria in children with diabetic ketoacidosis. 62
36084731 2022
12
Role of oral pentosan polysulfate in Bacillus Calmette-Guérin therapy in patients with non-muscle-invasive bladder cancer. 62
36067999 2022
13
Lens Free Holographic Imaging for Urinary Tract Infection Screening. 62
36129868 2022
14
Sulopenem For The Treatment of Complicated Urinary Tract Infection Including Pyelonephritis: A Phase 3 Randomized Trial. 62
36068705 2022
15
Correlation of Pyuria and Bacteriuria in Acute Care. 62
35580716 2022
16
Bladder malacoplakia: A case report. 62
36159544 2022
17
Two cases of pyelonephritis with bacteremia by Staphylococcus epidermidis in male patients with nephrolithiasis: Case reports and a literature review. 62
35525700 2022
18
Hemophagocytic lymphohistiocytosis diagnosed by bone marrow trephine biopsy in living post-COVID-19 patients: case report and mini-review. 62
35699822 2022
19
Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review). 62
35815191 2022
20
The role of a urine dipstick in the diagnosis of the acute scrotum. 62
35783592 2022
21
Clinical characteristics of patients with inguinal hernia mesh migration into the bladder. 62
35795103 2022
22
Outgrowing skin involvement in malakoplakia after kidney transplantation: A case report. 62
35811147 2022
23
Xanthogranulomatous pyelonephritis in a pediatric patient. 62
33877258 2022
24
COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center. 62
36017292 2022
25
Comparison of Fragmentation and Dusting Modality Using Holmium YAG Laser during Ureteroscopy for the Treatment of Ureteral Stone: A Single-Center's Experience. 62
35887919 2022
26
Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial. 62
35750460 2022
27
Association of Pyuria with Uropathogens in Young Children. 62
35120990 2022
28
The Influence of Non-E. Coli or Extended-Spectrum β-Lactamase-Producing Bacterial Growth on the Follow-Up Procedure of Infants with the First Febrile Urinary Tract Infection. 62
35727527 2022
29
Updated evidence of the safety and efficacy of the miniaturized percutaneous nephrolithotomy with holmium laser lithotripsy for the treatment of recurrent nephrolithiasis. 62
35731058 2022
30
Giant bladder stone resulting in renal failure and concurrent bladder cancer: A case report. 62
35658321 2022
31
Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre. 62
35677001 2022
32
Incidence of urinary tract infection following initiation of intermittent catheterization among patients with recent spinal cord injury in Germany and the Netherlands. 62
33054606 2022
33
Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature. 62
36160637 2022
34
Clinical features of acute focal bacterial nephritis in adults. 62
35508538 2022
35
A systematic review and meta-analysis of risk factors and treatment choices in emphysematous pyelonephritis. 62
35103928 2022
36
Emphysematous Pyelonephritis with IgA-Dominant Infection-Related Glomerulonephritis: An Unusual Picture. 62
35695404 2022
37
Effect of urine-specific gravity on performance of bacteriuria in predicting urine culture results. 62
34897695 2022
38
Preoperative polymicrobial urine culture: An analysis of the risk of perioperative urinary tract infection. 62
34602341 2022
39
[Acute interstitial nephritis: clinical presentation and diagnosis]. 62
35235259 2022
40
The Role of Preoperative Urinalysis in Predicting Postoperative Infection After Retrograde Intrarenal Surgery in Patients with Sterile Urine Culture. 62
35420056 2022
41
Asymptomatic Pyuria as a Prognostic Biomarker in Autosomal Dominant Polycystic Kidney Disease. 62
35582184 2022
42
Point-of-care urine Gram stain led to narrower-spectrum antimicrobial selection for febrile urinary tract infection in adolescents and adults. 62
35227212 2022
43
Determinants of pyelonephritis onset in patients with obstructive urolithiasis. 62
34338097 2022
44
Novel urine biomarkers to distinguish UTI from culture-negative pyuria. 62
34272611 2022
45
Retroperitoneal emphysema caused by a renal abscess: a case report. 62
34118830 2022
46
Opportunities for antibiotic stewardship in emergency department or hospitalized patients with asymptomatic bacteriuria: identifying risk factors for antibiotic treatment. 62
36310811 2022
47
Clinical investigation on acute pyelonephritis without pyuria: a retrospective observational study. 62
34411474 2022
48
Emphysematous cystitis due to Streptococcus salivarius infection in a patient with a neurogenic bladder. 62
35106284 2022
49
A novel approach to screening and managing the urinary tract infections suspected sample in the general human population. 62
36093203 2022
50
Circumcision and Risk of Febrile Urinary Tract Infection in Boys with Posterior Urethral Valves: Result of the CIRCUP Randomized Trial. 62
34563412 2022

Variations for Pyuria

Expression for Pyuria

Search GEO for disease gene expression data for Pyuria.

Pathways for Pyuria

Pathways related to Pyuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 KLK3 IL6 F2 C3 ALB
2 10.98 IL6 CRP C3

GO Terms for Pyuria

Cellular components related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.65 IL6 F2 C3 B2M ALB
2 extracellular space GO:0005615 9.64 PRTN3 LCN2 KLK3 IL6 GPT F2

Biological processes related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.1 IL6 F2 CRP

Molecular functions related to Pyuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.56 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
3 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
4 enterobactin binding GO:1903981 8.92 LCN2 ALB

Sources for Pyuria

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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