Pyuria disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pyuria

MalaCards integrated aliases for Pyuria:

Name: Pyuria ¹¹ ⁴³ ¹⁴ ⁷¹ ⁷⁵

Pus Cells in Urine ¹¹

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:1439

MeSH ⁴³ D011776

NCIt ⁴⁹ C119028

SNOMED-CT ⁶⁸ 4800001

UMLS ⁷¹ C0034359

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Summaries for Pyuria

MalaCards based summary: Pyuria, also known as pus cells in urine, is related to bacteriuria and kawasaki disease, and has symptoms including genitourinary signs and symptoms An important gene associated with Pyuria is CRP (C-Reactive Protein), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Extrafollicular B cell activation by SARS-CoV-2. The drug Cranberry has been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and kidney.

Wikipedia: ⁷⁵ Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or... more...

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Related Diseases for Pyuria

Diseases related to Pyuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 668)

#	Related Disease	Score	Top Affiliating Genes
1	bacteriuria	31.5	IL6 CRP ALB
2	kawasaki disease	30.7	ITPKC GPT CRP
3	pyelonephritis	30.6	LCN2 IL6 GPT CRP ALB
4	urethritis	30.5	KLK3 IL6 CRP ALB
5	acute pyelonephritis	30.2	LCN2 IL6 HAVCR1 CRP ALB
6	gastroenteritis	30.2	IL6 CRP ALB
7	miliary tuberculosis	30.1	GPT CRP ALB
8	urogenital tuberculosis	30.1	KLK3 CRP ALB
9	diabetes mellitus, ketosis-prone	30.1	GPT CRP ALB
10	urolithiasis	30.1	IL6 F2 ALB
11	renal tuberculosis	30.1	CRP B2M ALB
12	chronic pyelonephritis	30.1	CRP B2M ALB
13	neurogenic bladder	30.0	UPK3A KLK3 CRP ALB
14	protein-energy malnutrition	30.0	IL6 GPT ALB
15	cystitis	30.0	UPK3A IL6 CRP
16	chronic kidney disease	30.0	LCN2 IL6 CRP B2M ALB
17	autosomal dominant polycystic kidney disease	29.9	LCN2 IL6 HAVCR1 CRP ALB
18	vasculitis	29.9	PRTN3 LCN2 IL6 CRP C3
19	prostatitis	29.9	KLK3 IL6 C3
20	pneumonia	29.9	IL6 GPT CRP ALB
21	meningitis	29.9	IL6 CRP C3 ALB
22	schistosomiasis	29.9	GPT F2 CRP ALB
23	tuberculous epididymitis	29.8	UPK3A KLK3 CRP
24	acquired immunodeficiency syndrome	29.8	IL6 CRP B2M ALB
25	neutropenia	29.8	IL6 GPT CRP ALB
26	vesicoureteral reflux	29.7	UPK3A LCN2 HAVCR1 CRP B2M ALB
27	cerebrovascular disease	29.7	IL6 F2 CRP ALB
28	kidney disease	29.4	PRTN3 LCN2 IL6 F2 CRP B2M
29	glomerulonephritis	29.4	PRTN3 LCN2 IL6 CRP C3 B2M
30	systemic lupus erythematosus	29.3	PRTN3 LCN2 IL6 F2 CRP C3
31	urinary tract obstruction	29.2	UPK3A LCN2 KLK3 IL6 HAVCR1 CRP
32	nephrotic syndrome	29.2	LCN2 IL6 F2 CRP C3 B2M
33	prostatic hypertrophy	29.1	KLK3 CRP ATP4A ATP12A ALB
34	urinary tract infection	29.0	UPK3A LCN2 KLK3 IL6 HAVCR1 GPT
35	acute kidney failure	28.9	PRTN3 LCN2 IL6 HAVCR1 GPT F2
36	hydronephrosis	28.8	UPK3A LCN2 KLK3 IL6 HAVCR1 CRP
37	nutritional deficiency disease	28.8	IL6 F2 CRP ATP4A ATP12A ALB
38	deficiency anemia	28.1	PRTN3 IL6 GPT F2 CRP B2M
39	intestinal tuberculosis	10.4	CRP ALB
40	dipetalonemiasis	10.4	GPT ALB
41	ankylosing spondylitis 3	10.4	CRP ALB
42	spontaneous tension pneumothorax	10.4	GPT CRP
43	nutmeg liver	10.4	GPT ALB
44	acute vascular insufficiency of intestine	10.4	CRP ALB
45	type 1 diabetes mellitus 19	10.4	LCN2 HAVCR1
46	tuberculous peritonitis	10.4	CRP ALB
47	ludwig's angina	10.4	CRP C3
48	heterophyiasis	10.4	GPT ALB
49	viral laryngitis	10.3	GPT CRP
50	ventricular tachycardia, catecholaminergic polymorphic, 4	10.3	LCN2 HAVCR1

Graphical network of the top 20 diseases related to Pyuria:

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Symptoms & Phenotypes for Pyuria

UMLS symptoms related to Pyuria:

genitourinary signs and symptoms

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Drugs & Therapeutics for Pyuria

Drugs for Pyuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Cranberry	Approved, Investigational	Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis.	Unknown status	NCT00305071	Phase 2	compound cranberry extract tablet
2	Does Postoperative Pyuria Influence Treatment Outcomes After Photoselective Vaporization of the Prostate (PVP)?: A Short-term Serial Follow-up Study	Unknown status	NCT02241902
3	Kinetics of Procalcitonin, C-reactive Protein and Pyuria in Uncomplicated Pyelonephritis in Women: A Pilot Study	Completed	NCT00805181
4	The Frequency of Leukocytes and Nitrites in the Urine of Healthy Adults	Completed	NCT04055675

Search NIH Clinical Center for Pyuria

Cochrane evidence based reviews: pyuria

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Genetic Tests for Pyuria

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Anatomical Context for Pyuria

Organs/tissues related to Pyuria:

MalaCards : Prostate, Spinal Cord, Kidney, Lymph Node, Neutrophil, Bone Marrow, Colon

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Publications for Pyuria

Articles related to Pyuria:

(show top 50) (show all 1975)

#	Title	Authors	PMID	Year
1	Autoantibodies in lupus nephritis useful in distinguishing proliferative nephritis from membranous nephritis. ⁶²	Asanuma Y...Tamura N	36469011	2022
2	Diagnostic test accuracy of dipstick urinalysis for diagnosing urinary tract infection in febrile infants attending the emergency department. ⁶²	Waterfield T...Paediatric Emergency Research in the UK and Ireland (PERUKI)	36002228	2022
3	The Diagnostic Accuracy Of Procalcitonin for Urinary Tract Infection in Hospitalized Older Adults: a Prospective Study. ⁶²	Choi JJ...Glesby MJ	34997392	2022
4	The influence of repeated flares in response to therapy and prognosis in lupus nephritis. ⁶²	Perez-Arias AA...Mejia-Vilet JM	36318456	2022
5	Patterns of renal toxicity from the combination of pemetrexed and pembrolizumab for advanced nonsquamous non-small-cell lung cancer (NSCLC): A single-center experience. ⁶²	De Giglio A...Gelsomino F	36356493	2022
6	A nomogram for predicting the development of serious bacterial infections in febrile term neonates: A single medical center experience in Southern Taiwan. ⁶²	Li SY...Chiou YH	36008242	2022
7	Man With Fever and Pyuria. ⁶²	Huang HH...Yang PJ	36153059	2022
8	Urine bacterial culture growth and association with urine sedimentation and clinical findings in cats with acute kidney injury. ⁶²	Siu K...Summers SC	35748789	2022
9	Leukocyte Esterase and Nitrite Urine Reagent Strip Utility Under Altered Assay Conditions in Dogs. ⁶²	Farris J...Krimer PM	36049239	2022
10	Pyelonephritis of an ectopic right kidney pretending as acute appendicitis: An unusual case. ⁶²	Manglik A...Akash A	35985113	2022
11	Pyuria in children with diabetic ketoacidosis. ⁶²	Glaser NS...Pediatric Emergency Care Applied Research Network (PECARN) FLUID Study Group	36084731	2022
12	Role of oral pentosan polysulfate in Bacillus Calmette-Guérin therapy in patients with non-muscle-invasive bladder cancer. ⁶²	Lee HY...Kwon DD	36067999	2022
13	Lens Free Holographic Imaging for Urinary Tract Infection Screening. ⁶²	McKay GN...Durr NJ	36129868	2022
14	Sulopenem For The Treatment of Complicated Urinary Tract Infection Including Pyelonephritis: A Phase 3 Randomized Trial. ⁶²	Dunne MW...Puttagunta S	36068705	2022
15	Correlation of Pyuria and Bacteriuria in Acute Care. ⁶²	Cheng B...Cox W	35580716	2022
16	Bladder malacoplakia: A case report. ⁶²	Wang HK...Chen B	36159544	2022
17	Two cases of pyelonephritis with bacteremia by Staphylococcus epidermidis in male patients with nephrolithiasis: Case reports and a literature review. ⁶²	Yogo A...Segawa T	35525700	2022
18	Hemophagocytic lymphohistiocytosis diagnosed by bone marrow trephine biopsy in living post-COVID-19 patients: case report and mini-review. ⁶²	Ioannou M...Vageli DP	35699822	2022
19	Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review). ⁶²	Parazzini F...Cipriani S	35815191	2022
20	The role of a urine dipstick in the diagnosis of the acute scrotum. ⁶²	Tissot S...Grills R	35783592	2022
21	Clinical characteristics of patients with inguinal hernia mesh migration into the bladder. ⁶²	Akimoto T...Enomoto Y	35795103	2022
22	Outgrowing skin involvement in malakoplakia after kidney transplantation: A case report. ⁶²	Lee EJ...Cha HJ	35811147	2022
23	Xanthogranulomatous pyelonephritis in a pediatric patient. ⁶²	Caixeta KEG...Barbosa KCK	33877258	2022
24	COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center. ⁶²	Gupta R...Ram Dhayal I	36017292	2022
25	Comparison of Fragmentation and Dusting Modality Using Holmium YAG Laser during Ureteroscopy for the Treatment of Ureteral Stone: A Single-Center's Experience. ⁶²	Chen BH...Chiu AW	35887919	2022
26	Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial. ⁶²	Toth B...Csupor D	35750460	2022
27	Association of Pyuria with Uropathogens in Young Children. ⁶²	Nadeem S...Hennes HM	35120990	2022
28	The Influence of Non-E. Coli or Extended-Spectrum β-Lactamase-Producing Bacterial Growth on the Follow-Up Procedure of Infants with the First Febrile Urinary Tract Infection. ⁶²	Kavruk M...Kasap Demir B	35727527	2022
29	Updated evidence of the safety and efficacy of the miniaturized percutaneous nephrolithotomy with holmium laser lithotripsy for the treatment of recurrent nephrolithiasis. ⁶²	Nguyen MA...Le NV	35731058	2022
30	Giant bladder stone resulting in renal failure and concurrent bladder cancer: A case report. ⁶²	Bestari MG...Octavian I	35658321	2022
31	Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre. ⁶²	Perween N...Kumar SK	35677001	2022
32	Incidence of urinary tract infection following initiation of intermittent catheterization among patients with recent spinal cord injury in Germany and the Netherlands. ⁶²	Berger A...Weiss J	33054606	2022
33	Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature. ⁶²	Mohamed M...Macfarlane J	36160637	2022
34	Clinical features of acute focal bacterial nephritis in adults. ⁶²	Jiao S...Zhu J	35508538	2022
35	A systematic review and meta-analysis of risk factors and treatment choices in emphysematous pyelonephritis. ⁶²	Desai R...Batura D	35103928	2022
36	Emphysematous Pyelonephritis with IgA-Dominant Infection-Related Glomerulonephritis: An Unusual Picture. ⁶²	Chienwichai K...Chang A	35695404	2022
37	Effect of urine-specific gravity on performance of bacteriuria in predicting urine culture results. ⁶²	Torre M...Foster JD	34897695	2022
38	Preoperative polymicrobial urine culture: An analysis of the risk of perioperative urinary tract infection. ⁶²	Breuleux C...Baboudjian M	34602341	2022
39	[Acute interstitial nephritis: clinical presentation and diagnosis]. ⁶²	Dos Reis D...Berchtold L	35235259	2022
40	The Role of Preoperative Urinalysis in Predicting Postoperative Infection After Retrograde Intrarenal Surgery in Patients with Sterile Urine Culture. ⁶²	Kazan O...Atis G	35420056	2022
41	Asymptomatic Pyuria as a Prognostic Biomarker in Autosomal Dominant Polycystic Kidney Disease. ⁶²	Jones BE...Chebib FT	35582184	2022
42	Point-of-care urine Gram stain led to narrower-spectrum antimicrobial selection for febrile urinary tract infection in adolescents and adults. ⁶²	Taniguchi T...Narita M	35227212	2022
43	Determinants of pyelonephritis onset in patients with obstructive urolithiasis. ⁶²	Abi Tayeh G...El Helou E	34338097	2022
44	Novel urine biomarkers to distinguish UTI from culture-negative pyuria. ⁶²	Hill EB...Spencer JD	34272611	2022
45	Retroperitoneal emphysema caused by a renal abscess: a case report. ⁶²	Song SH...Bae EH	34118830	2022
46	Opportunities for antibiotic stewardship in emergency department or hospitalized patients with asymptomatic bacteriuria: identifying risk factors for antibiotic treatment. ⁶²	Bixby ML...Hirsch EB	36310811	2022
47	Clinical investigation on acute pyelonephritis without pyuria: a retrospective observational study. ⁶²	Song HK...Lee JH	34411474	2022
48	Emphysematous cystitis due to Streptococcus salivarius infection in a patient with a neurogenic bladder. ⁶²	Okada S...Iinuma M	35106284	2022
49	A novel approach to screening and managing the urinary tract infections suspected sample in the general human population. ⁶²	Szmulik M...Wozniak-Kosek A	36093203	2022
50	Circumcision and Risk of Febrile Urinary Tract Infection in Boys with Posterior Urethral Valves: Result of the CIRCUP Randomized Trial. ⁶²	Harper L...Sauvat F	34563412	2022

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Genes for Pyuria

Genes related to Pyuria (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRP	C-Reactive Protein	Protein Coding	7.83	DISEASES inferred ¹⁴
2	ALB	Albumin	Protein Coding	6.96	DISEASES inferred ¹⁴
3	LCN2	Lipocalin 2	Protein Coding	6.43	DISEASES inferred ¹⁴
4	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.35	DISEASES inferred ¹⁴
5	HAVCR1	Hepatitis A Virus Cellular Receptor 1	Protein Coding	5.81	DISEASES inferred ¹⁴
6	KLK3	Kallikrein Related Peptidase 3	Protein Coding	5.78	DISEASES inferred ¹⁴
7	C3	Complement C3	Protein Coding	5.75	DISEASES inferred ¹⁴
8	MIR4511	MicroRNA 4511	RNA Gene	5.69	DISEASES inferred ¹⁴
9	B2M	Beta-2-Microglobulin	Protein Coding	5.68	DISEASES inferred ¹⁴
10	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	5.62	DISEASES inferred ¹⁴
11	IL6	Interleukin 6	Protein Coding	5.57	DISEASES inferred ¹⁴
12	F2	Coagulation Factor II, Thrombin	Protein Coding	5.52	DISEASES inferred ¹⁴
13	PRTN3	Proteinase 3	Protein Coding	5.5	DISEASES inferred ¹⁴
14	MIR6124	MicroRNA 6124	RNA Gene	5.48	DISEASES inferred ¹⁴
15	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	5.43	DISEASES inferred ¹⁴
16	UPK3A	Uroplakin 3A	Protein Coding	5.43	DISEASES inferred ¹⁴
17	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	5.43	DISEASES inferred ¹⁴
18	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	5.4	DISEASES inferred ¹⁴

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Variations for Pyuria

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Expression for Pyuria

Search GEO for disease gene expression data for Pyuria.

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Pathways for Pyuria

Pathways related to Pyuria according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.39	KLK3 IL6 F2 C3 ALB
2	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	10.98	IL6 CRP C3

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GO Terms for Pyuria

Cellular components related to Pyuria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.65	IL6 F2 C3 B2M ALB
2	extracellular space	GO:0005615	9.64	PRTN3 LCN2 KLK3 IL6 GPT F2

Biological processes related to Pyuria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	9.1	IL6 F2 CRP

Molecular functions related to Pyuria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	P-type sodium:potassium-exchanging transporter activity	GO:0005391	9.56	ATP4A ATP12A
2	P-type potassium:proton transporter activity	GO:0008900	9.26	ATP4A ATP12A
3	P-type potassium transmembrane transporter activity	GO:0008556	9.16	ATP4A ATP12A
4	enterobactin binding	GO:1903981	8.92	LCN2 ALB

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Sources for Pyuria

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PYR004 MIFTS: 35	Pyuria Categories: Nephrological diseases	Data Licensing For inquiries, contact: [email protected]
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