MCID: QFV001
MIFTS: 61

Q Fever

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Q Fever

MalaCards integrated aliases for Q Fever:

Name: Q Fever 12 73 20 58 3 44 15 17 70 32
Infection Due to Coxiella Burnetii 12 58
Quadrilateral Fever 58 70
Query Fever 20 58
Coxiella Burnetii Fever 20
Pneumonia in Q Fever 70
Q Fever Pneumonia 20
Nine Mile Fever 58
Coxiellosis 58

Characteristics:

Orphanet epidemiological data:

58
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Q Fever

GARD : 20 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and waste products of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection. In less than 5% of cases the affected people with acute Q fever infection develop a chronic Q fever. Treatment of the acute form is made with antibiotics. The chronic form's treatment depends on the symptoms.

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and epidemic typhus, and has symptoms including fever, arthralgia and myalgia. An important gene associated with Q Fever is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Tetracycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and heart, and related phenotypes are granuloma and muscle weakness

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

CDC : 3 Q fever is a disease caused by the bacteria Coxiella burnetii. This bacteria naturally infects some animals, such as goats, sheep, and cattle. C. burnetii bacteria are found in the birth products (i.e. placenta, amniotic fluid), urine, feces, and milk of infected animals. People can get infected by breathing in dust that has been contaminated by infected animal feces, urine, milk, and birth products. Some people never get sick; however, those who do usually develop flu-like symptoms including fever, chills, fatigue, and muscle pain.

Wikipedia : 73 Q fever or query fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 800)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.9 TNF TLR2 IL6 IL10 IFNG
2 epidemic typhus 31.3 TNF IL10 CCL5
3 infective endocarditis 31.2 TNF TLR2 IL6
4 pericarditis 31.2 TNF IL6 IL1B IFNG
5 spotted fever 31.1 TNF IL10 IFNG CCL5
6 brucellosis 31.1 TNF TLR4 SLC11A1 IL6 IL4 IL10
7 meningoencephalitis 31.0 TNF IL6 IL10 CCL5
8 exanthem 30.9 TNF IL6 IL1B IL10 IFNG
9 syphilis 30.8 TNF IL6 IFNG
10 optic neuritis 30.8 TNF IL6 IL1B IL10
11 scrub typhus 30.8 TNF TLR4 TLR2 IL1B IL10 IFNG
12 vasculitis 30.7 TNF MBL2 IL6 CCL2
13 cryoglobulinemia 30.7 TNF IL6 IL1B IFNG
14 chronic recurrent multifocal osteomyelitis 30.7 TNF IL6 IL1B
15 aortitis 30.6 TNF IL6 IL1B
16 myelitis 30.6 TNF IL6 IL10
17 aortic aneurysm, familial abdominal, 1 30.6 TNF IL6 IL1B IL10 CCL2
18 disseminated intravascular coagulation 30.6 TNF IL6 IL10
19 haemophilus influenzae 30.5 TNF TLR2
20 aseptic meningitis 30.5 TNF IL1B IL10 IFNG
21 severe combined immunodeficiency 30.5 IL6 IL4 IL10 IFNG
22 myocarditis 30.5 TNF TLR4 IL6 IL4 IL1B IL10
23 adult respiratory distress syndrome 30.4 TNF IL6 IL1B IL10
24 hypersplenism 30.4 TLR4 IL4 IFNG
25 erythema nodosum 30.4 TNF NOD2 IL6 IL1B IL10 IFNG
26 purpura 30.4 TNF IL6 IL4 IL10 IFNG
27 chronic fatigue syndrome 30.4 TNF TLR4 IL6 IL4 IL1B IL10
28 smallpox 30.4 TNF IL4 IL1B IFNG
29 lymphopenia 30.3 IL6 IL4 IL10 IFNG
30 encephalitis 30.3 TNF TLR2 IL6 IL1B IL10 CCL5
31 hepatitis a 30.3 TNF TLR4 IL4 IL1B IL10 IFNG
32 mastitis 30.3 TLR2 NOD2 IL6 CCL5
33 bursitis 30.3 TNF IL6 IL1B
34 neutropenia 30.3 TNF MBL2 IL6 IL1B IL10
35 iridocyclitis 30.2 TNF TLR4 IL6 IL1B IL10
36 tularemia 30.2 TNF TLR4 TLR2 SLC11A1 MYD88 MBL2
37 diarrhea 30.2 TNF TLR4 NOD2 IL6 IL1B IL10
38 proliferative glomerulonephritis 30.2 IL6 IL4 IFNG CCL2
39 bacterial pneumonia 30.2 TNF TLR4 TLR2 IL6 IL1B IL10
40 adult-onset still's disease 30.2 TNF IL6 IL1B IFNG
41 mental depression 30.2 TNF IL6 IL1B
42 prosthetic joint infection 30.1 TLR4 TLR2 MBL2 IL6 IL1B
43 pulmonary edema 30.1 TNF IL1B IL10
44 thyroiditis 30.1 TNF IL6 IL4 IL1B IL10 IFNG
45 disease by infectious agent 30.1 TNF TLR4 TLR2 SLC11A1 NOD2 MBL2
46 dengue disease 30.1 TNF MBL2 IL10 IFNG CCL5
47 myositis 30.1 TNF IL6 IL1B IFNG
48 vascular disease 30.1 TNF TLR4 IL6 IL10 IFNG CCL2
49 septic arthritis 30.1 TNF TLR4 TLR2 IFNG
50 tenosynovitis 30.1 TNF NOD2 IL6 IL1B

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Human phenotypes related to Q Fever:

58 31 (show top 50) (show all 55)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 granuloma 58 31 hallmark (90%) Very frequent (99-80%) HP:0032252
2 muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0001324
3 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
4 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
5 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
6 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
7 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
8 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
9 elevated erythrocyte sedimentation rate 58 31 frequent (33%) Frequent (79-30%) HP:0003565
10 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
11 immunodeficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002721
12 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
13 abnormal heart valve morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001654
14 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
15 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
16 hematuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000790
17 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
18 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
19 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
20 endocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100584
21 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
22 vasculitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002633
23 pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002090
24 hepatosplenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001433
25 night sweats 58 31 occasional (7.5%) Occasional (29-5%) HP:0030166
26 rheumatoid factor positive 58 31 occasional (7.5%) Occasional (29-5%) HP:0002923
27 maculopapular exanthema 58 31 occasional (7.5%) Occasional (29-5%) HP:0040186
28 smooth muscle antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0003262
29 anticardiolipin igg antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0020136
30 antimitochondrial antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0030167
31 increased circulating antibody level 31 occasional (7.5%) HP:0010702
32 encephalitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002383
33 pericarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0001701
34 myocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0012819
35 meningitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001287
36 osteomyelitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002754
37 cholecystitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001082
38 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
39 pleural effusion 58 31 very rare (1%) Very rare (<4-1%) HP:0002202
40 lymphadenopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0002716
41 pericardial effusion 58 31 very rare (1%) Very rare (<4-1%) HP:0001698
42 cryoglobulinemia 58 31 very rare (1%) Very rare (<4-1%) HP:0100778
43 amyloidosis 58 31 very rare (1%) Very rare (<4-1%) HP:0011034
44 lupus anticoagulant 58 31 very rare (1%) Very rare (<4-1%) HP:0025343
45 abnormal pulmonary interstitial morphology 31 very rare (1%) HP:0006530
46 abnormal left ventricular function 31 very rare (1%) HP:0005162
47 abnormality of the cardiovascular system 58 Occasional (29-5%)
48 abnormality of the skeletal system 58 Occasional (29-5%)
49 abnormality of the liver 58 Occasional (29-5%)
50 increased antibody level in blood 58 Occasional (29-5%)

Symptoms:

12
  • fever
  • arthralgia
  • myalgia
  • cough
  • headache
  • pleuritic chest pain

GenomeRNAi Phenotypes related to Q Fever according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.68 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.68 TLR4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.68 TLR4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.68 IL10
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.68 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-135 9.68 ARG1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.68 ARG1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 9.68 TLR4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.68 IL10
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-174 9.68 NOD2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.68 NOD2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.68 IL10
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 9.68 NOD2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-192 9.68 NOD2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.68 NOD2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.68 IL10
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.68 IL10
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.68 NOD2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.68 ARG1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.68 NOD2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.68 NOD2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-80 9.68 IL10
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-99 9.68 ARG1

MGI Mouse Phenotypes related to Q Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 ARG1 CCL5 IFNG IL10 IL1B IL4
2 immune system MP:0005387 10.32 ARG1 CCL2 CCL5 IFNG IL10 IL1B
3 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL4 IL6 MYD88 NOD2
4 integument MP:0010771 9.97 IFNG IL10 IL1B IL4 IL6 SLC11A1
5 liver/biliary system MP:0005370 9.91 ARG1 IFNG IL10 IL4 IL6 MYD88
6 neoplasm MP:0002006 9.81 IFNG IL10 IL1B IL6 MYD88 SLC11A1
7 respiratory system MP:0005388 9.56 IFNG IL10 IL4 IL6 MYD88 TLR2
8 skeleton MP:0005390 9.36 IFNG IL10 IL1B IL4 IL6 MBL2

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3 Antibiotics, Antitubercular Phase 4
4 Anti-Bacterial Agents Phase 4
5 Antiparasitic Agents Phase 4
6 Antimalarials Phase 4
7 Liver Extracts Phase 4
8 Anti-Infective Agents Phase 4
9 Antiprotozoal Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4 Doxycycline;Placebo
2 Continued Evaluation of the Safety of Q Fever Vaccine, Phase I, Inactivated, Freeze Dried, NDBR 105, in Those at Risk of Exposure to Coxiella Burnetii, A Phase 2 Study Completed NCT00584454 Phase 2
3 Evaluation of the Safety and Immunogenicity of Q Fever Vaccine, Phase I, Inactivated, Dried, NDBR 105, in Subjects at Risk of Exposure to Coxiella Burnetii Withdrawn NCT02092142 Phase 2
4 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
5 Q Fever and Auto-immunity Unknown status NCT02822807
6 Cost-effectiveness of a Screening Strategy for Q Fever Among Pregnant Women in Risk Areas: a Clustered Randomized Controlled Trial Unknown status NCT01095328
7 Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Unknown status NCT03334019
8 Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island Completed NCT02898402

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

40
Liver, Placenta, Heart, Bone Marrow, Bone, Smooth Muscle, Skin

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 4629)
# Title Authors PMID Year
1
Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis. 61
33553561 2021
2
Q fever prevention and vaccination: Australian livestock farmers' knowledge and attitudes to inform a One Health approach. 61
33748388 2021
3
Coxiella burnetii seroprevalence and Q fever in Australian wildlife rehabilitators. 61
33319024 2021
4
Coxiella burnetii in the environment: A systematic review and critical appraisal of sampling methods. 61
33314733 2021
5
Parturient Cat As a Potential Reservoir for Coxiella burnetii: A Hidden Threat to Pet Owners. 61
33434106 2021
6
Prevalence and spatial distribution of Coxiella burnetii seropositivity in northern Australian beef cattle adjusted for diagnostic test uncertainty. 61
33556799 2021
7
Update on prevalence and distribution pattern of tick-borne diseases among humans in India: a review. 61
33797610 2021
8
The Coxiella burnetii effector protein CaeB modulates endoplasmatic reticulum (ER) stress signalling and is required for efficient replication in Galleria mellonella. 61
33355405 2021
9
Current perspectives on the occurrence of Q fever: highlighting the need for systematic surveillance for a neglected zoonotic disease in Indian subcontinent. 61
33314653 2021
10
Q fever vertebral osteomyelitis among adults: a case series and literature review. 61
33475036 2021
11
Chronic Q fever vertebral osteomyelitis, an underrecognized clinical entity. 61
33475041 2021
12
Evaluation of three immunological assays to mitigate the risk of transboundary spread of Coxiella burnetii by alpacas. 61
33655708 2021
13
Risk of seropositivity to Coxiella burnetii in humans living in areas with endemically infected cattle: No way for specific prevention. 61
33428296 2021
14
Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. 61
33789347 2021
15
A Freedom of Coxiella burnetii Infection Survey in European Bison (Bison bonasus) in Poland. 61
33804478 2021
16
Contributions of lipopolysaccharide and the type IVB secretion system to Coxiella burnetii vaccine efficacy and reactogenicity. 61
33741986 2021
17
Coxiella burnetii Shedding in Milk and Molecular Typing of Strains Infecting Dairy Cows in Greece. 61
33802264 2021
18
Investigating the Role of Micromammals in the Ecology of Coxiella burnetii in Spain. 61
33801164 2021
19
Humoral immune response to Q fever vaccination of three sheep flocks naturally pre-infected with Coxiella burnetii. 61
33558108 2021
20
Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea. 61
33774480 2021
21
Laboratory diagnosis of 37 cases of Bartonella endocarditis based on enzyme immunoassay and real-time PCR. 61
33731411 2021
22
[Q fever endocarditis - a rare condition with high mortality]. 61
33788204 2021
23
[A case report of Q-fever endocarditis diagnosed by metagenomic next generation sequencing]. 61
33663175 2021
24
Current tools for the diagnosis and detection of spotted fever group Rickettsia. 61
33713627 2021
25
HPLC methods for choloroquine determination in biological samples and pharmaceutical products. 61
33738722 2021
26
The Development of an Abattoir-Based Surveillance System in Lao PDR for the Detection of Zoonoses in Large Ruminants: Q Fever and Brucellosis Seroepidemiology as a Pilot Study. 61
33800515 2021
27
Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. 61
33770095 2021
28
Prevalence of Coxiella burnetii seropositivity and shedding in farm, pet and feral cats and associated risk factors in farm cats in Quebec, Canada. 61
33583452 2021
29
Q fever: a rare but potentially life-threatening zoonotic disease. 61
33602758 2021
30
Cardiac tamponade secondary to acute Q Fever. 61
33573836 2021
31
Q Fever: Seroprevalence, Risk Factors in Slaughter Livestock and Genotypes of Coxiella burnetii in South Africa. 61
33668366 2021
32
Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever. 61
33566203 2021
33
Primary aortoduodenal fistula and chronic Q fever infection. 61
33542018 2021
34
The European Union One Health 2019 Zoonoses Report. 61
33680134 2021
35
Sero-epidemiology investigation of Coxiella burnetii in domestic ruminants throughout most Greek regions. 61
32790038 2021
36
Identification of Coxiella burnetii in Raw Milk of Livestock Animal in Iran. 61
33531905 2021
37
Partial DnaK protein expression from Coxiella-like endosymbiont of Rhipicephalus annulatus tick. 61
33793664 2021
38
Coxiellaceae in Ticks from Human, Domestic and Wild Hosts from Sardinia, Italy: High Diversity of Coxiella-like Endosymbionts. 61
33492605 2021
39
Diagnostic challenge of Q fever osteoarticular infection. 61
33572020 2021
40
Severe Fever With Thrombocytopenia Syndrome With Q Fever Coinfection in an 8-Year-Old Girl. 61
33105338 2021
41
Q fever presenting as myocarditis. 61
33643842 2021
42
Concept of an Active Surveillance System for Q Fever in German Small Ruminants-Conflicts Between Best Practices and Feasibility. 61
33644150 2021
43
Vector competence of the African argasid tick Ornithodoros moubata for the Q fever agent Coxiella burnetii. 61
33406079 2021
44
Occupations at risk of contracting zoonoses of public health significance in Québec. 61
33679248 2021
45
Rodent Ectoparasites in the Middle East: A Systematic Review and Meta-Analysis. 61
33572506 2021
46
Vector-borne diseases in Iran: epidemiology and key challenges. 61
33438476 2021
47
Q Fever Vertebral Osteomyelitis Complicating Vertebroplasty. 61
33478629 2021
48
Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia. 61
33493173 2021
49
Molecular epidemiology of Coxiella Brunetii in small ruminants in Punjab, Pakistan: a novel reporting analytical cross sectional study. 61
33394174 2021
50
Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection. 61
33177156 2020

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TNF TLR4 TLR2 TLR10 TLR1 SLC11A1
2
Show member pathways
13.75 TNF TLR4 IL6 IL4 IL1B IL10
3
Show member pathways
13.6 TNF IL6 IL4 IL1B IL10 IFNG
4
Show member pathways
13.57 TNF TLR4 TLR2 TLR10 TLR1 MYD88
5
Show member pathways
13.5 TNF NOD2 MYD88 IL6 IL4 IL1B
6
Show member pathways
13.37 TNF IL6 IL4 IL1B IL10 CCL5
7
Show member pathways
13.35 TNF TLR4 TLR2 TLR10 TLR1 MYD88
8
Show member pathways
13.33 TNF TLR4 TLR2 TLR1 MYD88 MBL2
9
Show member pathways
13.09 TNF TLR4 TLR2 MYD88 IL6 IL1B
10
Show member pathways
13.01 TNF TLR4 TLR2 MYD88 IL6 IL1B
11 12.98 TNF TLR2 MYD88 IL6 IL1B IFNG
12
Show member pathways
12.95 TNF IL6 IL4 IL1B IL10 IFNG
13
Show member pathways
12.91 TNF TLR4 TLR2 TLR10 TLR1 NOD2
14
Show member pathways
12.89 TNF TLR4 TLR2 RAB7A MYD88 IL6
15
Show member pathways
12.89 TNF TLR4 TLR2 TLR10 TLR1 MYD88
16
Show member pathways
12.79 TNF TLR4 TLR2 MYD88 IL6 IL4
17
Show member pathways
12.77 TNF TLR4 TLR2 NOD2 IL6 IL4
18
Show member pathways
12.76 TNF TLR4 TLR2 TLR10 TLR1 MYD88
19
Show member pathways
12.72 TNF IL6 IL1B IL10 IFNG CCL2
20 12.69 TNF TLR2 TLR1 MYD88 IL4 IL1B
21
Show member pathways
12.64 NOD2 MYD88 IL6 IL1B CCL5
22
Show member pathways
12.54 TNF TLR2 IL6 IL4 IL1B IFNG
23
Show member pathways
12.54 TNF IL6 IL4 IL1B IFNG CCL5
24 12.52 TNF TLR4 MYD88 IL1B CCL5
25
Show member pathways
12.51 TLR4 TLR2 TLR10 TLR1 MYD88
26
Show member pathways
12.48 TNF TLR4 TLR2 TLR10 TLR1 MYD88
27
Show member pathways
12.47 TNF TLR4 MYD88 IL6 IL1B IFNG
28
Show member pathways
12.46 IL6 IL4 IL10 IFNG
29
Show member pathways
12.46 TNF IL6 IL10 CCL5 CCL2
30
Show member pathways
12.45 TNF TLR4 TLR2 MYD88 IL4 IL1B
31 12.41 TNF TLR4 NOD2 MYD88 IL6 IL1B
32
Show member pathways
12.4 TNF IL6 IL4 IL1B IL10 IFNG
33 12.39 TNF TLR4 TLR2 TLR10 TLR1 IL6
34
Show member pathways
12.37 NOD2 MYD88 IL1B CCL2
35
Show member pathways
12.35 TNF MYD88 IL6 IL1B IL10
36 12.29 TNF TLR4 MYD88 IL6 IL1B IL10
37
Show member pathways
12.28 TNF TLR4 IL1B IFNG
38 12.26 TNF IL6 IL1B IL10
39 12.23 TLR4 TLR2 RAB7A MBL2
40 12.2 TNF IL6 IL4 IL1B IL10 CCL2
41 12.19 TNF IL1B IFNG CCL2
42
Show member pathways
12.19 TLR4 TLR2 TLR10 TLR1 IL1B
43 12.19 TNF NOD2 IL6 IL1B CCL5 CCL2
44
Show member pathways
12.19 TNF TLR4 TLR2 TLR1 MYD88 IL6
45 12.18 TNF TLR4 IL6 IL4 IL1B IFNG
46 12.16 TNF IL6 IL4 IL10 IFNG
47
Show member pathways
12.09 RAB7A IL4 IL1B IFNG
48 12.05 TNF TLR4 MYD88 IL1B
49 12.03 TNF IL6 IL1B CCL2
50 12.02 TNF IL6 IL4 IL1B

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 TNF MBL2 IL6 IL4 IL1B IL10
2 extracellular space GO:0005615 9.65 TNF MBL2 IL6 IL4 IL1B IL10
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR2 TLR1
4 phagocytic vesicle membrane GO:0030670 8.92 TLR2 TLR1 SLC11A1 RAB7A

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.43 TLR4 TLR2 TLR10 TLR1 MYD88 IL6
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.32 TNF TLR4 TLR2 SLC11A1 NOD2 IL6
3 immune system process GO:0002376 10.29 TLR4 TLR2 TLR10 TLR1 NOD2 MYD88
4 innate immune response GO:0045087 10.26 TLR4 TLR2 TLR10 TLR1 NOD2 MYD88
5 positive regulation of gene expression GO:0010628 10.21 TNF TLR4 TLR2 SLC11A1 MYD88 IL6
6 defense response to bacterium GO:0042742 10.17 TNF TLR4 SLC11A1 NOD2 MYD88 MBL2
7 cytokine-mediated signaling pathway GO:0019221 10.14 TNF MYD88 IL6 IL4 IL1B IL10
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.11 TNF TLR4 NOD2 CCL5 CCL2
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.06 TNF TLR4 NOD2 MYD88
10 defense response to Gram-positive bacterium GO:0050830 10.06 TNF TLR2 NOD2 MYD88 MBL2 IL6
11 response to lipopolysaccharide GO:0032496 10.06 TLR4 TLR2 SLC11A1 NOD2 MYD88 IL1B
12 inflammatory response GO:0006954 10.06 TNF TLR4 TLR2 TLR10 TLR1 SLC11A1
13 positive regulation of JNK cascade GO:0046330 10.05 TNF TLR4 NOD2 MYD88 IL1B
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.05 TNF TLR4 TLR2 NOD2 MYD88 IL6
15 activation of MAPK activity GO:0000187 10.04 TNF TLR4 NOD2 IL1B
16 regulation of insulin secretion GO:0050796 10.04 TNF IL6 IL1B IFNG CCL5
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.04 TNF IL6 IL4 IFNG CCL5
18 cellular response to organic cyclic compound GO:0071407 10.04 TNF NOD2 IL1B CCL5 CCL2
19 positive regulation of inflammatory response GO:0050729 10.04 TNF TLR4 TLR2 TLR10 IL1B IFNG
20 response to virus GO:0009615 10.03 TNF MYD88 IFNG CCL5
21 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TNF IL6 IL1B IL10
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.03 TNF TLR4 TLR2 NOD2 IL1B
23 cellular response to interferon-gamma GO:0071346 10.02 TLR4 TLR2 CCL5 CCL2
24 regulation of inflammatory response GO:0050727 10.02 TNF TLR4 NOD2 MYD88
25 positive regulation of interleukin-1 beta production GO:0032731 10.02 TNF TLR4 NOD2 IL6 IFNG
26 cellular response to lipopolysaccharide GO:0071222 10.02 TNF TLR4 NOD2 MYD88 IL6 IL1B
27 negative regulation of tumor necrosis factor production GO:0032720 10.01 TLR4 NOD2 IL4 IL10
28 positive regulation of interferon-gamma production GO:0032729 10 TNF TLR4 SLC11A1 IL1B
29 positive regulation of T cell proliferation GO:0042102 10 IL6 IL4 IL1B CCL5
30 positive regulation of smooth muscle cell proliferation GO:0048661 10 TNF MYD88 IL6 CCL5
31 positive regulation of phagocytosis GO:0050766 10 TNF SLC11A1 NOD2 IL1B IFNG
32 toll-like receptor signaling pathway GO:0002224 10 TLR4 TLR2 TLR10 TLR1 MYD88
33 humoral immune response GO:0006959 9.99 TNF IL6 IFNG CCL2
34 positive regulation of cytokine production GO:0001819 9.99 TNF SLC11A1 IL10 IFNG
35 positive regulation of nitric oxide biosynthetic process GO:0045429 9.98 TNF TLR4 IL1B IFNG
36 positive regulation of interleukin-12 production GO:0032735 9.97 TLR4 TLR2 NOD2 IFNG
37 protein kinase B signaling GO:0043491 9.97 TNF IL1B CCL5 CCL2
38 positive regulation of interleukin-10 production GO:0032733 9.97 TLR4 TLR2 NOD2 IL6 IL4
39 positive regulation of JAK-STAT cascade GO:0046427 9.96 TNF IL6 IL10 CCL5
40 cellular response to mechanical stimulus GO:0071260 9.95 TLR4 MYD88 IL1B
41 phagocytosis GO:0006909 9.95 TLR4 SLC11A1 MYD88
42 negative regulation of interleukin-6 production GO:0032715 9.95 TNF TLR4 IL10
43 defense response to protozoan GO:0042832 9.95 SLC11A1 MYD88 IL10 ARG1
44 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.95 TLR4 TLR2 TLR10 TLR1 MYD88
45 positive regulation of tumor necrosis factor production GO:0032760 9.95 TLR4 TLR2 TLR1 NOD2 MYD88 IL6
46 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
47 JNK cascade GO:0007254 9.93 TNF NOD2 MYD88
48 monocyte chemotaxis GO:0002548 9.92 IL6 CCL5 CCL2
49 negative regulation of interferon-gamma production GO:0032689 9.92 TLR4 NOD2 IL10
50 microglial cell activation GO:0001774 9.92 TNF TLR2 TLR1 IL4 IFNG

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.96 TNF TLR4 TLR2 TLR10 TLR1 MYD88
2 signaling receptor activity GO:0038023 9.71 TLR4 TLR2 TLR10 TLR1
3 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.46 TLR4 TLR2 TLR10 TLR1
4 lipopeptide binding GO:0071723 9.43 TLR2 TLR1
5 Toll-like receptor binding GO:0035325 9.37 TLR2 MYD88
6 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
7 NAD(P)+ nucleosidase activity GO:0050135 9.26 TLR4 TLR2 TLR10 TLR1
8 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL1B IL10 IFNG

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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