Aliases & Classifications for Q Fever

MalaCards integrated aliases for Q Fever:

Name: Q Fever 12 76 53 59 3 44 15 73
Infection Due to Coxiella Burnetii 12 59
Quadrilateral Fever 59 73
Query Fever 53 59
Coxiella Burnetii Fever 53
Pneumonia in Q Fever 73
Q Fever Pneumonia 53
Nine Mile Fever 59
Coxiellosis 59

Characteristics:

Orphanet epidemiological data:

59
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11100
ICD10 33 A78
ICD9CM 35 083.0
MeSH 44 D011778
NCIt 50 C34970
Orphanet 59 ORPHA781
MESH via Orphanet 45 D011778
UMLS via Orphanet 74 C0034362 C2973787
ICD10 via Orphanet 34 A78

Summaries for Q Fever

NIH Rare Diseases : 53 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and waste products of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection. In less than 5% of cases the affected people with acute Q fever infection develop a chronic Q fever. Treatment of the acute form is made with antibiotics. The chronic form's treatment depends on the symptoms.

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and spotted fever, and has symptoms including fever, headache and cough. An important gene associated with Q Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Doxycycline and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and monocytes, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia : 76 Q... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.7 IL10 TLR2 TNF
2 spotted fever 31.0 IFNG IL10 TNF
3 osteomyelitis 30.9 IFNG IL1B TNF
4 ross river fever 30.7 CD40LG IL10
5 miller fisher syndrome 30.6 CD40LG TNF
6 cat-scratch disease 30.5 CD40LG IFNG
7 coccidioidomycosis 30.4 CD40LG TLR4
8 neuritis 30.4 IFNG IL1B TNF
9 prostatitis 30.3 IL10 IL1B TNF
10 plasmodium falciparum malaria 30.3 IFNG IL10 TNF
11 chronic fatigue syndrome 30.3 IL10 IL1B TNF
12 mumps 30.2 CD40LG IFNG TNF
13 prosthetic joint infection 30.1 IL1B TLR2 TLR4
14 peritonitis 30.0 IL10 IL1B TLR2 TNF
15 arthritis 29.9 IFNG IL10 IL1B TNF
16 campylobacteriosis 29.8 IFNG IL1B TLR4
17 uveitis 29.8 IFNG IL10 NOD2 TNF
18 leptospirosis 29.8 CD40LG IL10 IL1B TLR2 TNF
19 spondylitis 29.8 CD40LG NOD2 TNF
20 brucellosis 29.7 CD40LG IFNG IL10 TLR4 TNF
21 glomerulonephritis 29.7 CD40LG CD79A IL1B
22 pertussis 29.4 IL10 IL1B TLR4 TNF
23 trench fever 29.3 CD40LG TLR2 TLR4 TNF
24 pneumonia 29.2 CD40LG IL10 IL1B TLR2 TLR4 TNF
25 systemic lupus erythematosus 29.1 CD40LG CD79A IFNG IL10 TNF
26 scrub typhus 29.0 CD40LG IL10 IL1B TLR2 TLR4 TNF
27 lyme disease 28.6 CD40LG IL1B TLR1 TLR2 TNF
28 crohn's disease 28.5 IL10 IL1B NOD2 TLR4 TNF
29 autoimmune disease 28.4 CD40LG CD79A IFNG IL10 IL1B TNF
30 malaria 27.7 CD40LG IFNG IL10 IL1B TLR2 TLR4
31 toxoplasmosis 27.5 CD40LG CD79A IFNG IL10 IL1B TLR4
32 chlamydia 27.0 CD40LG CD79A IFNG IL10 IL1B TLR2
33 melioidosis 26.6 IFNG IL10 TLR1 TLR10 TLR2 TLR4
34 punctate inner choroidopathy 11.0 IL10 TNF
35 tropical endomyocardial fibrosis 10.9 IL10 TNF
36 microscopic polyangiitis 10.9 IL10 TNF
37 multifocal choroiditis 10.9 IL10 TNF
38 tungiasis 10.9 IL10 TNF
39 endomyocardial fibrosis 10.9 IL10 TNF
40 transient hypogammaglobulinemia 10.9 IL10 TNF
41 hyperlucent lung 10.9 IFNG IL10
42 tick infestation 10.8
43 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
44 choroiditis 10.8 IL10 TNF
45 kashin-beck disease 10.8 IL1B TNF
46 trichosporonosis 10.8 IFNG TNF
47 chronic beryllium disease 10.8 IFNG TNF
48 baylisascariasis 10.8 IFNG IL10
49 periodontitis, chronic 10.8 IL1B TLR2
50 idiopathic achalasia 10.7 IL10 TNF

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Symptoms:

12
  • fever
  • headache
  • cough
  • pleuritic chest pain
  • myalgia
  • arthralgia

MGI Mouse Phenotypes related to Q Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 NOD2 IFNG TLR1 TLR2 IL10 CD40LG
2 cellular MP:0005384 10.08 CD79A NOD2 IFNG IL10 CD40LG TLR4
3 immune system MP:0005387 10.07 NOD2 IFNG TLR1 TLR2 IL10 CD40LG
4 homeostasis/metabolism MP:0005376 10.06 IL1B CD79A NOD2 IFNG IL10 CD40LG
5 digestive/alimentary MP:0005381 9.93 NOD2 IFNG TLR2 IL10 TNF TLR4
6 integument MP:0010771 9.87 IL1B IFNG TLR2 IL10 CD40LG TNF
7 liver/biliary system MP:0005370 9.73 CD79A IFNG TLR2 IL10 TNF TLR4
8 neoplasm MP:0002006 9.7 IFNG TLR2 IL10 IL1B CD79A TNF
9 nervous system MP:0003631 9.56 IL1B CD79A IFNG IL10 CD40LG TLR4
10 skeleton MP:0005390 9.23 NOD2 IFNG TLR2 IL10 CD40LG IL1B

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4
6 Antimalarials Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Liver Extracts Phase 4
10 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4 Doxycycline;Placebo
2 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
3 Safety and Immunogenicity of Q Fever Vaccine Withdrawn NCT02092142 Phase 2
4 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328 Not Applicable
5 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
6 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
7 Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island Completed NCT02898402
8 Q Fever and Auto-immunity Recruiting NCT02822807 Not Applicable
9 Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Recruiting NCT03334019

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

41
Testes, Liver, Monocytes, Bone, Bone Marrow, B Cells, T Cells

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 715)
# Title Authors Year
1
Vascular infection with outside-in vertebral destruction in chronic Q fever. ( 29856356 )
2018
2
A Nationwide Seroepidemiologic Study on Q Fever Antibodies in Sheep of Portugal. ( 29969389 )
2018
3
Q fever spondylitis: 2 cases report. ( 29887174 )
2018
4
Airborne geographical dispersal of Q fever from livestock holdings to human communities: a systematic review and critical appraisal of evidence. ( 29764368 )
2018
5
Understanding Q Fever Risk to Humans in Minnesota Through the Analysis of Spatiotemporal Trends. ( 29261435 )
2018
6
Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia. ( 29336685 )
2018
7
Familiarity of general practitioners with Q fever decreases hospitalisation risk. ( 29845941 )
2018
8
FISH and PNA FISH for the diagnosis of Q fever endocarditis and vascular infections. ( 29899006 )
2018
9
Willingness of veterinarians in Australia to recommend Q fever vaccination in veterinary personnel: Implications for workplace health and safety compliance. ( 29856835 )
2018
10
Vascular infection and vertebral destruction in a patient with Q fever. ( 29412972 )
2018
11
Q Fever in Military Firefighters during Cadet Training in Brazil. ( 29943714 )
2018
12
Tache Noire in a Patient with Acute Q Fever. ( 29298443 )
2018
13
Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People's Democratic Republic. ( 29649313 )
2018
14
Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. ( 29908707 )
2018
15
Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area. ( 29426406 )
2018
16
Q fever: an under-reported reportable communicable disease. ( 29941056 )
2018
17
In this issue - June 2018: Diversity of Haemophilus parasuis isolates from Australian piggeriesa88A^a88Detection of bovine noroviruses in Australian dairy cattlea88A^a88Myocardial adenomatoid tumour in a calfa88A^a88Hypertrophic cardiomyopathy in a horse a88A^a88A history of veterinary education a88A^a88Review of Q fever notifications in Victoria. ( 29878327 )
2018
18
Outbreaks of abortions by Coxiella burnetii in small ruminant flocks and a longitudinal serological approach on archived bulk tank milk suggest Q fever emergence in Central Portugal. ( 29799172 )
2018
19
Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature. ( 29440832 )
2018
20
Farming, Q fever and public health: agricultural practices and beyond. ( 29321921 )
2018
21
The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever. ( 29325142 )
2018
22
Q fever epidemic in Cayenne, French Guiana, epidemiologically linked to three-toed sloth. ( 29406281 )
2018
23
An outbreak of Q fever associated with parturient cat exposure at an animal refuge and veterinary clinic in southeast Queensland. ( 29644762 )
2018
24
Interferon-I^ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome. ( 29804281 )
2018
25
Review of 20a88years of human acute Q fever notifications in Victoria, 1994-2013. ( 29878326 )
2018
26
Draft Genome Sequence of<i>Coxiella burnetii</i>Historical Strain Leningrad-2, Isolated from Blood of a Patient with Acute Q Fever in Saint Petersburg, Russia. ( 29348343 )
2018
27
Q fever: A rural disease with potential urban consequences ( 29621839 )
2018
28
The First Serological Study of Q Fever in Humans in Lebanon. ( 29336692 )
2018
29
Does Q fever contribute to pathogenesis of non-Hodgkin lymphoma? ( 29650494 )
2018
30
Seroprevalence of brucellosis and Q fever (Coxiellosis) in cattle herds in Maigana and Birnin Gwari agro-ecological zone of Kaduna State, Nigeria. ( 29675780 )
2018
31
Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study. ( 28723794 )
2017
32
Coxiella burnetii infection (Q fever) mimicking systemic lupus erythematosus: two cases. ( 29251170 )
2017
33
Pulmonary manifestations of Q fever: analysis of 38 patients. ( 29268408 )
2017
34
Presentation and diagnosis of acute Q fever in Portugal - A case series. ( 28070491 )
2017
35
Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever. ( 28549166 )
2017
36
Seroprevalence of rickettsial infections and Q fever in Bhutan. ( 29176880 )
2017
37
Retrospective Examination of Q Fever Endocarditis: An Underdiagnosed Disease in the Mainland of China. ( 28051025 )
2017
38
Dot map cartograms for detection of infectious disease outbreaks: an application to Q fever, the Netherlands and pertussis, Germany. ( 28681721 )
2017
39
Workshop on Q fever. ( 28854800 )
2017
40
Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass. ( 29270326 )
2017
41
Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity. ( 28779434 )
2017
42
Atypical outbreak of Q fever affecting low-risk residents of a remote rural town in New South Wales. ( 28899307 )
2017
43
Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. ( 28709838 )
2017
44
CXCL9, a promising biomarker in the diagnosis of chronic Q fever. ( 28793883 )
2017
45
First Case of Q Fever Endocarditis Involving the Melody(Ar) Transcatheter Pulmonary Valve in an Afebrile Child. ( 28948320 )
2017
46
Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic. ( 29157226 )
2017
47
Seroprevalence and risk factors for &amp;lt;i&amp;gt;Coxiella burnetii&amp;lt;/i&amp;gt;, the causative agent of Q fever in the dromedary camel (&amp;lt;i&amp;gt;Camelus dromedarius&amp;lt;/i&amp;gt;) population in Algeria. ( 28893076 )
2017
48
The clinical challenge of chronic Q fever with isolated liver involvement. ( 28715899 )
2017
49
Diagnosis of Acute Q Fever by Detection of<i>Coxiella burnetii</i>DNA using Real-Time PCR, Employing a Commercial Genesig Easy Kit. ( 29207703 )
2017
50
Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development. ( 28854806 )
2017

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 CD40LG CD79A IFNG IL10 IL1B NOD2
2
Show member pathways
13.38 CD40LG IL10 IL1B TLR1 TLR10 TLR2
3
Show member pathways
13.29 CD40LG IFNG IL10 IL1B NOD2 TNF
4
Show member pathways
12.91 IFNG IL10 IL1B NOD2 TLR1 TLR10
5
Show member pathways
12.83 CD40LG IFNG IL10 IL1B TNF
6
Show member pathways
12.78 CD79A IFNG IL1B TLR1 TLR10 TLR2
7
Show member pathways
12.77 IFNG IL1B TLR2 TLR4 TNF
8
Show member pathways
12.7 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
9
Show member pathways
12.69 IFNG IL1B TLR4 TNF
10
Show member pathways
12.61 CD40LG IFNG IL1B TNF
11
Show member pathways
12.59 IFNG IL10 IL1B TNF
12
Show member pathways
12.54 IFNG IL10 IL1B TNF
13
Show member pathways
12.45 CD40LG IFNG IL10 IL1B TNF
14
Show member pathways
12.42 IFNG IL10 IL1B NOD2 TLR2 TLR4
15
Show member pathways
12.4 CD40LG IL1B TLR1 TLR10 TLR2 TLR4
16
Show member pathways
12.37 TLR1 TLR10 TLR2 TLR4
17 12.37 CD40LG CD79A IFNG IL10 IL1B TLR1
18
Show member pathways
12.32 IFNG IL1B TLR2 TNF
19
Show member pathways
12.29 TLR1 TLR10 TLR2 TLR4 TNF
20
Show member pathways
12.26 IFNG IL1B TLR4 TNF
21
Show member pathways
12.22 IFNG IL1B TLR1 TLR2 TLR4 TNF
22
Show member pathways
12.21 IFNG IL1B TLR4 TNF
23 12.2 IFNG TLR1 TLR10 TLR2 TLR4 TNF
24
Show member pathways
12.18 CD40LG IFNG IL10 IL1B TLR2 TLR4
25 12.11 IL10 IL1B TNF
26
Show member pathways
12.08 IL1B TLR1 TLR10 TLR2 TLR4
27 12.04 IFNG IL1B TLR4 TNF
28 12.03 IFNG IL1B TNF
29
Show member pathways
12.03 IFNG IL10 IL1B TLR1 TLR10 TLR2
30 12.02 CD79A IFNG IL10 TNF
31 12 IFNG IL1B TNF
32 11.94 IL10 IL1B TNF
33 11.93 CD40LG IL1B TLR4 TNF
34 11.91 IL1B NOD2 TNF
35 11.9 IFNG IL1B TLR2 TLR4 TNF
36 11.89 IFNG IL10 IL1B TLR2 TLR4 TNF
37 11.87 TLR1 TLR10 TLR2 TLR4
38 11.84 IFNG IL10 IL1B TNF
39 11.81 IL10 IL1B TLR4 TNF
40 11.81 IFNG IL10 IL1B NOD2 TLR1 TLR2
41 11.8 IFNG IL1B TLR4
42 11.79 IFNG IL10 IL1B TNF
43
Show member pathways
11.74 CD40LG IFNG TNF
44
Show member pathways
11.72 CD40LG IFNG IL1B TNF
45 11.64 IL1B TLR2 TLR4 TNF
46 11.56 IFNG IL1B TLR2 TLR4 TNF
47 11.55 IL10 IL1B TNF
48 11.53 IFNG IL1B TNF
49 11.5 IFNG IL1B TNF
50 11.43 IFNG IL10 IL1B TNF

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CD40LG NOD2 TLR2 TLR4 TNF
2 external side of plasma membrane GO:0009897 9.62 CD40LG CD79A TLR4 TNF
3 integral component of plasma membrane GO:0005887 9.5 CD40LG CD79A TLR1 TLR10 TLR2 TLR4
4 membrane raft GO:0045121 9.46 CD79A TLR1 TLR2 TNF
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.98 IL10 IL1B TLR2 TLR4
2 defense response to bacterium GO:0042742 9.97 IL10 NOD2 TLR1 TLR4 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B NOD2 TLR4 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.92 IFNG IL1B TNF
5 defense response GO:0006952 9.92 NOD2 TLR1 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.92 IL10 TLR4 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.91 IL10 IL1B TNF
8 activation of MAPK activity GO:0000187 9.91 IL1B NOD2 TLR4 TNF
9 regulation of inflammatory response GO:0050727 9.89 NOD2 TLR4 TNF
10 positive regulation of inflammatory response GO:0050729 9.89 TLR10 TLR2 TLR4
11 cellular response to organic cyclic compound GO:0071407 9.88 IL1B NOD2 TNF
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG IL1B NOD2 TLR2 TLR4 TNF
13 B cell differentiation GO:0030183 9.87 CD40LG CD79A IL10
14 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
15 positive regulation of JNK cascade GO:0046330 9.86 IL1B NOD2 TLR4 TNF
16 positive regulation of tumor necrosis factor production GO:0032760 9.85 NOD2 TLR2 TLR4
17 positive regulation of interferon-gamma production GO:0032729 9.84 IL1B TLR4 TNF
18 toll-like receptor signaling pathway GO:0002224 9.84 TLR1 TLR10 TLR2 TLR4
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B TLR4 TNF
20 B cell proliferation GO:0042100 9.81 CD40LG CD79A IL10
21 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.81 TLR1 TLR10 TLR2 TLR4
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.8 IL1B NOD2 TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR2 TLR4 TNF
24 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR4 TNF
25 positive regulation of interleukin-12 production GO:0032735 9.78 CD40LG IFNG TLR2 TLR4
26 positive regulation of chemokine production GO:0032722 9.77 TLR2 TLR4 TNF
27 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B NOD2 TLR2 TLR4 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.76 IFNG IL1B TNF
29 positive regulation of interleukin-10 production GO:0032733 9.76 CD40LG NOD2 TLR2 TLR4
30 positive regulation of protein complex assembly GO:0031334 9.75 IFNG TNF
31 positive regulation of osteoclast differentiation GO:0045672 9.75 IFNG TNF
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.75 NOD2 TLR2 TLR4
33 positive regulation of stress-activated MAPK cascade GO:0032874 9.74 NOD2 TLR4
34 negative regulation of lipid catabolic process GO:0050995 9.74 IL1B TNF
35 cell activation GO:0001775 9.74 TLR1 TLR2
36 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 NOD2 TLR4
37 positive regulation of macrophage activation GO:0043032 9.74 IL10 TLR4
38 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
39 positive regulation of interleukin-8 secretion GO:2000484 9.73 TLR1 TLR2
40 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
41 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
42 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.73 TLR1 TLR4
43 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 TLR4
44 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TLR4
45 macrophage activation GO:0042116 9.72 TLR1 TLR4
46 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
48 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.72 IL1B NOD2 TLR2 TLR4 TNF
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
50 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.56 CD79A TLR1 TLR10 TLR4
2 peptidoglycan binding GO:0042834 9.37 NOD2 TLR2
3 lipopeptide binding GO:0071723 9.16 TLR1 TLR2
4 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL1B TNF
5 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
6 protein binding GO:0005515 10.1 CD40LG CD79A IFNG IL10 IL1B LNX2

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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