MCID: QFV001
MIFTS: 62

Q Fever

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Q Fever

MalaCards integrated aliases for Q Fever:

Name: Q Fever 12 76 53 59 3 44 15 73
Infection Due to Coxiella Burnetii 12 59
Quadrilateral Fever 59 73
Query Fever 53 59
Coxiella Burnetii Fever 53
Pneumonia in Q Fever 73
Q Fever Pneumonia 53
Nine Mile Fever 59
Coxiellosis 59

Characteristics:

Orphanet epidemiological data:

59
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11100
ICD10 33 A78
ICD9CM 35 083.0
MeSH 44 D011778
NCIt 50 C34970
SNOMED-CT 68 86012006
Orphanet 59 ORPHA781
MESH via Orphanet 45 D011778
UMLS via Orphanet 74 C0034362 C2973787
ICD10 via Orphanet 34 A78

Summaries for Q Fever

NIH Rare Diseases : 53 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and waste products of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection. In less than 5% of cases the affected people with acute Q fever infection develop a chronic Q fever. Treatment of the acute form is made with antibiotics. The chronic form's treatment depends on the symptoms.

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and spotted fever, and has symptoms including fever, arthralgia and myalgia. An important gene associated with Q Fever is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Doxycycline and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

CDC : 3 0 Transmission Signs and Symptoms Diagnosis and Testing Treatment Prevention Epidemiology and Statistics For healthcare providers For Public Health Officials Publications and Resources

Wikipedia : 76 Q�fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 417)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.2 IL10 IL6 TLR2 TNF
2 spotted fever 30.7 IFNG IL10 TNF
3 osteomyelitis 30.4 TNF IL6 IL1B IL10 IFNG
4 pneumonia 30.4 TNF TLR4 TLR2 IL6 IL1B IL10
5 coccidioidomycosis 30.4 TLR4 IL10
6 brucellosis 30.3 IFNG IL10 IL4 IL6 TLR4 TNF
7 scrub typhus 30.3 TNF TLR4 TLR2 IL1B IL10
8 miliary tuberculosis 30.1 TNF IFNG
9 chronic fatigue syndrome 30.0 IL10 IL1B IL6 TNF
10 neuritis 30.0 IFNG IL1B IL4 TNF
11 prosthetic joint infection 30.0 IL1B TLR2 TLR4
12 legionellosis 30.0 IL1B TLR2 TLR4 TNF
13 plasmodium falciparum malaria 29.9 TNF IL10 IFNG
14 adult respiratory distress syndrome 29.9 IL10 IL6 TNF
15 temporal arteritis 29.9 IFNG IL6 TNF
16 acute respiratory distress syndrome 29.9 IL1B IL6 TNF
17 cytomegalovirus infection 29.9 IL1B IL6 TNF
18 proliferative glomerulonephritis 29.8 IFNG IL4 IL6
19 peritonitis 29.8 TNF TLR2 IL6 IL1B IL10
20 trench fever 29.8 TLR2 TLR4 TNF
21 leptospirosis 29.7 IFNG IL10 IL1B IL6 TLR1 TLR2
22 campylobacteriosis 29.7 IFNG IL1B TLR4
23 crohn's disease 29.7 TNF NOD2 IL10
24 demyelinating disease 29.7 IFNG IL10 IL1B TNF
25 pericarditis 29.7 IFNG IL1B IL6 TNF
26 lyme disease 29.6 TNF TLR2 TLR1 IL6 IL1B
27 anterior uveitis 29.6 TNF TLR4 TLR2 IL6
28 spondylitis 29.6 IL6 NOD2 TNF
29 uveitis 29.6 TNF NOD2 IL4 IL10 IFNG
30 viral infectious disease 29.6 TNF IL6 IL4 IL1B IL10 IFNG
31 arthritis 29.5 IFNG IL10 IL1B IL6 NOD2 TNF
32 pertussis 29.5 IL10 IL1B IL6 TLR4 TNF
33 autoimmune disease 29.4 IFNG IL10 IL1B IL4 IL6 TNF
34 echinococcosis 29.3 IFNG IL10 IL6 TLR2 TLR4 TNF
35 lymphadenitis 29.3 IFNG IL10 IL1B NOD2 TLR4 TNF
36 rheumatoid arthritis 29.1 TNF TLR4 TLR2 IL6 IL4 IL1B
37 systemic lupus erythematosus 29.1 IFNG IL10 IL1B IL4 IL6 TLR2
38 chlamydia 28.9 IFNG IL10 IL1B IL4 IL6 TLR2
39 toxoplasmosis 28.9 IFNG IL10 IL1B IL4 IL6 TLR2
40 malaria 28.9 TNF TLR4 TLR2 IL6 IL4 IL1B
41 melioidosis 28.9 IFNG IL10 IL6 TLR1 TLR10 TLR2
42 asthma 28.8 IL1B IL10 IFNG ARG1 IL4 IL6
43 tick infestation 11.0
44 hepatitis 10.5
45 cow milk allergy 10.3 TNF IL10
46 choroiditis 10.3 TNF IL10
47 trichuriasis 10.3 TNF IL10
48 transient hypogammaglobulinemia 10.3 TNF IL10
49 mucocutaneous leishmaniasis 10.3 TNF IL10
50 idiopathic achalasia 10.3 TNF IL10

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Symptoms:

12
  • fever
  • arthralgia
  • myalgia
  • cough
  • headache
  • pleuritic chest pain

GenomeRNAi Phenotypes related to Q Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.47 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.47 ARG1 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.47 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.47 TLR4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.47 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.47 IL10
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.47 ARG1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.47 IL10
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 ARG1 IL10 NOD2 TLR4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.47 NOD2

MGI Mouse Phenotypes related to Q Fever:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 ARG1 IFNG IL10 IL1B IL4 IL6
2 immune system MP:0005387 10.2 ARG1 IFNG IL10 IL1B IL4 IL6
3 homeostasis/metabolism MP:0005376 10.18 ARG1 IFNG IL10 IL1B IL4 IL6
4 growth/size/body region MP:0005378 10.16 IFNG IL10 IL1B IL4 IL6 NOD2
5 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL4 IL6 NOD2 TLR2
6 mortality/aging MP:0010768 10.07 ARG1 IFNG IL10 IL1B IL4 IL6
7 integument MP:0010771 10.03 IFNG IL10 IL1B IL4 IL6 TLR2
8 liver/biliary system MP:0005370 10.01 ARG1 IFNG IL10 IL4 IL6 TLR2
9 nervous system MP:0003631 9.81 ARG1 IFNG IL10 IL1B IL4 IL6
10 muscle MP:0005369 9.8 IFNG IL10 IL6 TLR2 TLR4 TNF
11 neoplasm MP:0002006 9.8 IFNG IL10 IL1B IL6 TLR2 TLR4
12 respiratory system MP:0005388 9.5 IFNG IL10 IL4 IL6 TLR2 TLR4
13 skeleton MP:0005390 9.28 IFNG IL10 IL1B IL4 IL6 NOD2

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3 Anti-Bacterial Agents Phase 4
4 Liver Extracts Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Antiparasitic Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antimalarials Phase 4
9 Antiprotozoal Agents Phase 4
10 Vaccines Phase 2
11 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4 Doxycycline;Placebo
2 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
3 Safety and Immunogenicity of Q Fever Vaccine Withdrawn NCT02092142 Phase 2
4 Q Fever and Auto-immunity Unknown status NCT02822807 Not Applicable
5 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328 Not Applicable
6 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
7 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
8 Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island Completed NCT02898402
9 Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Recruiting NCT03334019

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

41
Testes, Liver, Bone, Prostate, Thyroid, Lung, Monocytes

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 1045)
# Title Authors Year
1
Vascular infection with outside-in vertebral destruction in chronic Q fever. ( 29856356 )
2018
2
A Nationwide Seroepidemiologic Study on Q Fever Antibodies in Sheep of Portugal. ( 29969389 )
2018
3
Q fever spondylitis: 2 cases report. ( 29887174 )
2018
4
Airborne geographical dispersal of Q fever from livestock holdings to human communities: a systematic review and critical appraisal of evidence. ( 29764368 )
2018
5
Understanding Q Fever Risk to Humans in Minnesota Through the Analysis of Spatiotemporal Trends. ( 29261435 )
2018
6
Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia. ( 29336685 )
2018
7
Familiarity of general practitioners with Q fever decreases hospitalisation risk. ( 29845941 )
2018
8
FISH and PNA FISH for the diagnosis of Q fever endocarditis and vascular infections. ( 29899006 )
2018
9
Willingness of veterinarians in Australia to recommend Q fever vaccination in veterinary personnel: Implications for workplace health and safety compliance. ( 29856835 )
2018
10
Vascular infection and vertebral destruction in a patient with Q fever. ( 29412972 )
2018
11
Q Fever in Military Firefighters during Cadet Training in Brazil. ( 29943714 )
2018
12
Tache Noire in a Patient with Acute Q Fever. ( 29298443 )
2018
13
Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People's Democratic Republic. ( 29649313 )
2018
14
Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. ( 29908707 )
2018
15
Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area. ( 29426406 )
2018
16
Q fever: an under-reported reportable communicable disease. ( 29941056 )
2018
17
In this issue - June 2018: Diversity of Haemophilus parasuis isolates from Australian piggeriesa88A^a88Detection of bovine noroviruses in Australian dairy cattlea88A^a88Myocardial adenomatoid tumour in a calfa88A^a88Hypertrophic cardiomyopathy in a horse a88A^a88A history of veterinary education a88A^a88Review of Q fever notifications in Victoria. ( 29878327 )
2018
18
Outbreaks of abortions by Coxiella burnetii in small ruminant flocks and a longitudinal serological approach on archived bulk tank milk suggest Q fever emergence in Central Portugal. ( 29799172 )
2018
19
Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature. ( 29440832 )
2018
20
Farming, Q fever and public health: agricultural practices and beyond. ( 29321921 )
2018
21
The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever. ( 29325142 )
2018
22
Q fever epidemic in Cayenne, French Guiana, epidemiologically linked to three-toed sloth. ( 29406281 )
2018
23
An outbreak of Q fever associated with parturient cat exposure at an animal refuge and veterinary clinic in southeast Queensland. ( 29644762 )
2018
24
Interferon-I^ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome. ( 29804281 )
2018
25
Review of 20a88years of human acute Q fever notifications in Victoria, 1994-2013. ( 29878326 )
2018
26
Draft Genome Sequence of<i>Coxiella burnetii</i>Historical Strain Leningrad-2, Isolated from Blood of a Patient with Acute Q Fever in Saint Petersburg, Russia. ( 29348343 )
2018
27
Q fever: A rural disease with potential urban consequences ( 29621839 )
2018
28
The First Serological Study of Q Fever in Humans in Lebanon. ( 29336692 )
2018
29
Does Q fever contribute to pathogenesis of non-Hodgkin lymphoma? ( 29650494 )
2018
30
Cross-sectional study of brucellosis and Q fever in Thailand among livestock in two districts at the Thai-Cambodian border, Sa Kaeo province. ( 30386815 )
2018
31
Seroprevalence of brucellosis and Q fever (Coxiellosis) in cattle herds in Maigana and Birnin Gwari agro-ecological zone of Kaduna State, Nigeria. ( 29675780 )
2018
32
Should Acute Q-Fever Patients be Screened for Valvulopathy to Prevent Endocarditis? ( 29471496 )
2018
33
Q fever endocarditis: First reported case in Mayotte. ( 29122408 )
2018
34
Frequency of Adverse Events Following Q Fever Immunisation in Young Adults. ( 30551615 )
2018
35
Unusual Presentation of Q Fever in a Kidney-Pancreas Transplant Recipient. ( 30548556 )
2018
36
Chronic Q fever-related complications and mortality: data from a nationwide cohort. ( 30543852 )
2018
37
Screening for Q fever. A tertiary care hospital-based experience in central Saudi Arabia. ( 30520500 )
2018
38
Trends in Q fever serologic testing by immunofluorescence from four large reference laboratories in the United States, 2012-2016. ( 30420599 )
2018
39
A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics. ( 30402920 )
2018
40
Hemodialysis vascular graft as a focus of persistent Q fever. ( 30368731 )
2018
41
De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever. ( 30315113 )
2018
42
Standardized guinea pig model for Q fever vaccine reactogenicity. ( 30312355 )
2018
43
Rickettsial Infections and Q Fever Amongst Febrile Patients in Bhutan. ( 30274410 )
2018
44
Molecular and immunological characterization of Hyalomma dromedarii and Hyalomma excavatum (Acari: Ixodidae) vectors of Q fever in camels. ( 30250371 )
2018
45
Molecular and serological data supporting the role of Q fever in abortions of sheep and goats in northern Egypt. ( 30243553 )
2018
46
Q fever: hospitalisation and other concerns. ( 30220667 )
2018
47
A case of Q fever with hepatitis and an atypical skin lesion. ( 30350538 )
2018
48
The Value of 18F-FDG PET/CT in Diagnosis and During Follow-up in 273 Patients with Chronic Q Fever. ( 28546336 )
2018
49
A rapid bio-optical sensor for diagnosing Q fever in clinical specimens. ( 29024445 )
2018
50
Leukocytoclastic vasculitis presenting in association with Coxiella burnetii (Q fever): A case report. ( 29028126 )
2018

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 ARG1 IFNG IL10 IL1B IL4 IL6
2
Show member pathways
13.64 IFNG IL10 IL1B IL4 IL6 TLR4
3
Show member pathways
13.46 IL10 IL1B IL4 IL6 TLR1 TLR10
4
Show member pathways
13.37 IFNG IL10 IL1B IL4 IL6 NOD2
5
Show member pathways
13.27 IFNG IL1B IL4 TLR1 TLR10 TLR2
6
Show member pathways
13.04 IL1B IL6 TLR2 TLR4 TNF
7
Show member pathways
13.03 IFNG IL10 IL1B IL6 NOD2 TLR1
8
Show member pathways
12.98 IL4 IL6 TLR2 TLR4 TNF
9
Show member pathways
12.92 IFNG IL10 IL1B IL4 IL6 TNF
10
Show member pathways
12.87 IFNG IL1B IL4 IL6 TLR2 TLR4
11
Show member pathways
12.79 IFNG IL1B IL6 TLR4 TNF
12
Show member pathways
12.79 IL1B IL6 TLR1 TLR10 TLR2 TLR4
13
Show member pathways
12.7 IL1B TLR1 TLR10 TLR2 TLR4 TNF
14 12.66 IFNG IL10 IL1B IL4 TLR1 TLR2
15
Show member pathways
12.65 IFNG IL10 IL1B IL4 IL6 NOD2
16
Show member pathways
12.64 IFNG IL10 IL1B IL6 TNF
17
Show member pathways
12.62 IFNG IL10 IL4 TNF
18
Show member pathways
12.53 IFNG IL10 IL1B IL4 IL6 TNF
19
Show member pathways
12.44 IFNG IL1B IL4 IL6 TLR2 TNF
20
Show member pathways
12.42 TLR1 TLR10 TLR2 TLR4
21
Show member pathways
12.42 IFNG IL1B IL4 IL6 TNF
22
Show member pathways
12.41 IFNG IL10 IL4 IL6
23
Show member pathways
12.39 IFNG IL1B IL6 TLR4 TNF
24
Show member pathways
12.37 IL6 TLR1 TLR10 TLR2 TLR4 TNF
25
Show member pathways
12.36 IFNG IL10 IL1B IL4 IL6 TNF
26
Show member pathways
12.34 IFNG IL10 IL1B IL4 TLR2 TLR4
27
Show member pathways
12.27 IL1B IL6 TLR2 TNF
28 12.27 IFNG IL6 TLR1 TLR10 TLR2 TLR4
29
Show member pathways
12.26 IL10 IL1B IL6 TNF
30
Show member pathways
12.26 IFNG IL1B TLR4 TNF
31
Show member pathways
12.25 IFNG IL1B IL4 IL6 TLR1 TLR2
32
Show member pathways
12.24 IL1B TLR1 TLR10 TLR2 TLR4
33 12.23 IL10 IL1B IL6 TNF
34
Show member pathways
12.16 IL1B TLR1 TLR10 TLR2 TLR4
35
Show member pathways
12.12 IFNG IL10 IL1B IL4 IL6
36 12.12 IFNG IL10 IL4 IL6 TNF
37 12.12 ARG1 IFNG IL1B IL4 IL6 TLR4
38 12.11 IL10 IL1B IL4 IL6 TNF
39 12.08 IFNG IL1B TNF
40 12.05 IL1B IL6 NOD2 TNF
41 12.04 IFNG IL1B TNF
42
Show member pathways
12.02 IFNG IL1B IL4 IL6 TLR1 TLR2
43 11.99 IL1B IL4 IL6 TNF
44
Show member pathways
11.98 IFNG IL1B IL4
45 11.97 IFNG IL1B IL6 TLR2 TLR4 TNF
46 11.95 IFNG IL1B IL6
47 11.93 IFNG IL1B IL6 TLR4
48 11.92 IFNG IL6 TLR4
49 11.92 IL1B IL6 TNF
50 11.92 TLR1 TLR10 TLR2 TLR4

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ARG1 IFNG IL10 IL1B IL4 IL6
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Name GO ID Score Top Affiliating Genes
1 activation of MAPK activity GO:0000187 9.97 IL1B NOD2 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.97 ARG1 IL10 IL1B TLR2 TLR4
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 IL10 IL1B IL6 TNF
4 defense response GO:0006952 9.94 NOD2 TLR1 TNF
5 positive regulation of JNK cascade GO:0046330 9.93 IL1B NOD2 TLR4 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.92 IL6 TLR2 TNF
7 positive regulation of inflammatory response GO:0050729 9.92 TLR10 TLR2 TLR4 TNF
8 inflammatory response GO:0006954 9.92 IL10 IL1B IL6 TLR1 TLR10 TLR2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 NOD2 TLR2 TLR4 TNF
10 cellular response to organic cyclic compound GO:0071407 9.9 IL1B NOD2 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 IFNG IL4 IL6
12 regulation of inflammatory response GO:0050727 9.9 NOD2 TLR4 TNF
13 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
14 positive regulation of T cell proliferation GO:0042102 9.89 IL1B IL4 IL6
15 humoral immune response GO:0006959 9.89 IFNG IL6 TNF
16 response to glucocorticoid GO:0051384 9.89 IL10 IL1B IL6 TNF
17 positive regulation of tumor necrosis factor production GO:0032760 9.88 NOD2 TLR2 TLR4
18 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IFNG IL1B TLR4 TNF
20 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TNF
21 negative regulation of neurogenesis GO:0050768 9.84 IL1B IL6 TNF
22 toll-like receptor signaling pathway GO:0002224 9.84 TLR1 TLR10 TLR2 TLR4
23 positive regulation of interleukin-12 production GO:0032735 9.83 IFNG TLR2 TLR4
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 IL1B TLR2 TLR4 TNF
25 positive regulation of interleukin-10 production GO:0032733 9.82 NOD2 TLR2 TLR4
26 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.81 TLR1 TLR10 TLR2 TLR4
27 positive regulation of glial cell proliferation GO:0060252 9.8 IL1B IL6 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 IFNG IL1B TNF
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B NOD2 TLR2 TLR4 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 NOD2 TLR2 TLR4
32 positive regulation of osteoclast differentiation GO:0045672 9.76 IFNG TNF
33 defense response to protozoan GO:0042832 9.76 ARG1 IL10
34 positive regulation of stress-activated MAPK cascade GO:0032874 9.76 NOD2 TLR4
35 microglial cell activation GO:0001774 9.76 TLR2 TNF
36 negative regulation of lipid catabolic process GO:0050995 9.76 IL1B TNF
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.76 NOD2 TLR4
38 positive regulation of macrophage activation GO:0043032 9.76 IL10 TLR4
39 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR4 TNF
40 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.75 IL1B TNF
41 negative regulation of growth of symbiont in host GO:0044130 9.75 IL10 TNF
42 positive regulation of interleukin-8 secretion GO:2000484 9.75 TLR1 TLR2
43 cell activation GO:0001775 9.75 TLR1 TLR2
44 I-kappaB phosphorylation GO:0007252 9.75 TLR2 TLR4
45 negative regulation of interleukin-17 production GO:0032700 9.75 IFNG TLR4
46 response to molecule of bacterial origin GO:0002237 9.75 IL10 TLR2
47 macrophage activation GO:0042116 9.74 TLR1 TLR4
48 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.74 TLR1 TLR4
49 cellular response to lipoteichoic acid GO:0071223 9.74 TLR2 TLR4
50 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ARG1 IFNG IL10 IL1B IL4 IL6
2 peptidoglycan binding GO:0042834 9.32 NOD2 TLR2
3 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
5 cytokine activity GO:0005125 9.1 IFNG IL10 IL1B IL4 IL6 TNF

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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